Patent application number | Description | Published |
20100302786 | LENS WITH CONTROLLED BACKLIGHT MANAGEMENT - A lens for distribution of light predominantly toward a preferential side from a light emitter having an emitter axis and defining an emitter plane. The lens has an emitter-adjacent base end forming an emitter-receiving opening to an emitter-surrounding cavity defined by an inner surface which includes a front sector centered on the preferential side and a back sector centered on the non-preferential side radially opposite the preferential side. The front and back sectors differ in their respective configurations for refracting light from the emitter. The lens further includes an primary back surface positioned to receive light from at least a portion of the inner-surface back sector and configured for total internal reflection (TIR) thereof. The inner-surface back sector and the primary back surface extend along substantially elliptical cross-sections in planes substantially parallel to the emitter plane. The emitter-adjacent base end forms a back opening to a back cavity substantially centered on the non-preferential side and partially bounded by the primary back surface. | 12-02-2010 |
20120281404 | LED Light Fixture with Facilitated Lensing Alignment and Method of Manufacture - LED lighting apparatus including (1) a plurality of primary lenses each over a corresponding one of LED arrays spaced on a circuit board, and (2) a one-piece lensing member over the circuit board and having a plurality of secondary lenses each spaced over one of the primary lenses on the circuit board, the circuit board and lensing member having first and second mating features positioned and configured for inter-engagement for high-precision lens alignment. The circuit board and one-piece lensing member are each joined to a mounting surface of a heat-conductive member, and such assembly, while facilitating high-efficiency assembly, does not interfere with high-precision lens alignment. | 11-08-2012 |
20120307503 | Multi-Lens LED-Array Optic System - Lighting apparatus having a first lens over the LED emitter and a second lens over the first lens, and including: a first optical surface which is a first-lens outer surface configured to refract light from the emitter; a second optical surface which is a second-lens inner surface spaced from the first optical surface; and a third optical surface which is a second-lens outer surface configured to refract light from the second optical surface toward a preferential side. One embodiment includes asymmetric primary and secondary lenses. | 12-06-2012 |
20130021804 | LENS WITH CONTROLLED BACKLIGHT MANAGEMENT - A lens for distribution of light predominantly toward a preferential side from a light emitter having an emitter axis and defining an emitter plane. The lens has an emitter-adjacent base end forming an emitter-receiving opening to an emitter-surrounding cavity defined by an inner surface which includes a front sector centered on the preferential side and a back sector centered on the non-preferential side radially opposite the preferential side. The front and back sectors differ in their respective configurations for refracting light from the emitter. The lens further includes an primary back surface positioned to receive light from at least a portion of the inner-surface back sector and configured for total internal reflection (TIR) thereof. The inner-surface back sector and the primary back surface extend along substantially elliptical cross-sections in planes substantially parallel to the emitter plane. The emitter-adjacent base end forms a back opening to a back cavity substantially centered on the non-preferential side and partially bounded by the primary back surface. | 01-24-2013 |
20140022797 | Lens with Controlled Backlight Management - A lens for distribution of light predominantly toward a preferential side from a light emitter having an emitter axis and defining an emitter plane. The lens has an emitter-adjacent base end forming an emitter-receiving opening to an emitter-surrounding cavity defined by an inner surface which includes a front sector centered on the preferential side and a back sector centered on the non-preferential side radially opposite the preferential side. The front and back sectors differ in their respective configurations for refracting light from the emitter. The lens further includes an primary back surface positioned to receive light from at least a portion of the inner-surface back sector and configured for total internal reflection (TIR) thereof. The inner-surface back sector and the primary back surface extend along substantially elliptical cross-sections in planes substantially parallel to the emitter plane. The emitter-adjacent base end forms a back opening to a back cavity substantially centered on the non-preferential side and partially bounded by the primary back surface. | 01-23-2014 |
20150285466 | Lens with Controlled Backlight Management - A lens for distribution of light predominantly toward a preferential side from a light emitter having an emitter axis. The lens includes an outer surface, a reflecting inner surface and a reflecting back surface. The reflecting inner surface is positioned and configured for total internal reflection (TIR) of received light toward the lens outer surface. The reflecting back surface is positioned and configured for total internal reflection (TIR) of received light toward the preferential side. | 10-08-2015 |
Patent application number | Description | Published |
20090082724 | MULTI-LAYER FILM WELDED ARTICULATED BALLOON - A method of fabrication of a medical balloon, and a balloon device useful for various medical balloon procedures, such as gastrointestinal, vascular, reproductive system, urinary system and pulmonary applications. At least two layers of a thermoplastic film are sealed at their peripheral edges and heat sealed at one or more locations inside an area enclosed by the sealed edges at predetermined locations, in one implementation of the balloon device. Such configuration enables the balloon to articulate to a desired shape upon inflation, with the desired shape being selected to accommodate a specific medical application. | 03-26-2009 |
20110295202 | MULTI-LAYER FILM WELDED ARTICULATED BALLOON - A method of fabrication of a medical balloon, and a balloon device useful for various medical balloon procedures, such as gastrointestinal, vascular, reproductive system, urinary system and pulmonary applications. At least two layers of a thermoplastic film are sealed at their peripheral edges and heat sealed at one or more locations inside an area enclosed by the sealed edges at predetermined locations, in one implementation of the balloon device. Such configuration enables the balloon to articulate to a desired shape upon inflation, with the desired shape being selected to accommodate a specific medical application. | 12-01-2011 |
20130085324 | MULTI-LAYER FILM WELDED ARTICULATED BALLOON - A method of fabrication of a medical balloon, and a balloon device useful for various medical balloon procedures, such as gastrointestinal, vascular, reproductive system, urinary system and pulmonary applications. At least two layers of a thermoplastic film are sealed at their peripheral edges and heat sealed at one or more locations inside an area enclosed by the sealed edges at predetermined locations, in one implementation of the balloon device. Such configuration enables the balloon to articulate to a desired shape upon inflation, with the desired shape being selected to accommodate a specific medical application. | 04-04-2013 |
20150182229 | MULTI-LAYER FILM WELDED ARTICULATED BALLOON - A method of fabrication of a medical balloon, and a balloon device useful for various medical balloon procedures, such as gastrointestinal, vascular, reproductive system, urinary system and pulmonary applications. At least two layers of a thermoplastic film are sealed at their peripheral edges and heat sealed at one or more locations inside an area enclosed by the sealed edges at predetermined locations, in one implementation of the balloon device. Such configuration enables the balloon to articulate to a desired shape upon inflation, with the desired shape being selected to accommodate a specific medical application. | 07-02-2015 |
20150190142 | MULTI-LAYER FILM WELDED ARTICULATED BALLOON - A method of fabrication of a medical balloon, and a balloon device useful for various medical balloon procedures, such as gastrointestinal, vascular, reproductive system, urinary system and pulmonary applications. At least two layers of a thermoplastic film are sealed at their peripheral edges and heat sealed at one or more locations inside an area enclosed by the sealed edges at predetermined locations, in one implementation of the balloon device. Such configuration enables the balloon to articulate to a desired shape upon inflation, with the desired shape being selected to accommodate a specific medical application. | 07-09-2015 |
Patent application number | Description | Published |
20110107847 | Acoustic Sensor For Averaging Pitot Tube Installation - Apparatus and method for detecting the mounting mode of a bluff body inserted into a fluid carrying conduit by detecting and displaying the natural frequency of vibration of the bluff body caused by the pressure of the flowing fluid. | 05-12-2011 |
20140260657 | PROCESS VARIABLE MEASUREMENT USING UNIVERSAL FLOW TECHNOLOGY CONNECTION PLATFORM - An apparatus for measuring flow of a process fluid includes an elongate spool providing a spool conduit therethrough adapted to be coupled in line with process piping to receive the flow of process fluid. A meter body is carried by the elongate spool and receives the spool conduit therethrough. The meter body includes a flow measurement component opening which extends from the spool conduit to outside of the meter body. A flow component is configured for placement in the flow measurement component opening of the meter body. A carrier is configured to removably mount to the meter body and couple the flow measurement component to the spool conduit through the flow measurement component opening. A flow measurement transmitter couples to the flow measurement component to measure the flow of process fluid based upon an interaction between the process fluid and the flow measurement component. | 09-18-2014 |
20140260658 | FLOWMETER PRIMARY ELEMENT WITH SENSORS - A process variable transmitter is configured as a flowmeter for measuring flow of a process fluid through a conduit. The transmitter includes a pitot tube extending into the conduit which creates a differential pressure in the process fluid due to flow of the process fluid. An upstream process variable sensor is mounted on the pitot tube and coupled to the flow of process fluid to sense an upstream process variable of the process fluid. A downstream process variable sensor is mounted on the pitot tube downstream of the upstream process variable sensor and coupled to the flow of process fluid to sense a downstream process variable of the process fluid. Measurement circuitry determines the flow of the process fluid based upon the upstream process variable and the downstream process variable. | 09-18-2014 |
20140260670 | PROCESS VARIABLE MEASUREMENT USING PRIMARY ELEMENT CONNECTION PLATFORM - An apparatus for measuring a process variable of a process fluid based upon a process variable sensor measurement, includes an elongate spool that provides a spool conduit therethrough adapted to be coupled in line with process piping to receive a flow of process fluid. A meter body is carried in the elongate spool and receives the spool conduit therethrough. The meter body has a primary element opening which extends from the spool conduit to outside of the meter body. A carrier is configured to removably mount to the meter body and includes a primary element in the spool conduit through the primary element opening. A process variable transmitter is coupled to the primary element and is configured to measure the process variable of process fluid. The meter body is preferably configured to receive different types of primary elements carried on the carrier. | 09-18-2014 |
20150276442 | CUSTOMIZABLE DUCT MOUNT PITOT TUBE PRIMARY ELEMENT - A customizable duct mount averaging pitot tube (APT) assembly for use with a duct to measure a flow of fluid in the duct is provided. The APT assembly includes an APT primary element extending longitudinally between a first end and a second end. The APT primary element has first and second internal chambers extending longitudinally between the first and second ends. The APT primary element further includes an upstream face with an upstream opening which opens to the first internal chamber and extends from the first end to the second end, and a downstream face with a downstream opening which opens to the second internal chamber and extends from the first end to the second end. First and second duct mount flanges mount the respective first and second ends of the APT primary element to the duct when the APT primary element is inserted in the duct. | 10-01-2015 |
20150346006 | FLOWMETER PRIMARY ELEMENT WITH SENSORS - A process variable transmitter is configured as a flowmeter for measuring flow of a process fluid through a conduit. The transmitter includes a pitot tube extending into the conduit which creates a differential pressure in the process fluid due to flow of the process fluid. An upstream process variable sensor is mounted on the pitot tube and coupled to the flow of process fluid to sense an upstream process variable of the process fluid. A downstream process variable sensor is mounted on the pitot tube downstream of the upstream process variable sensor and coupled to the flow of process fluid to sense a downstream process variable of the process fluid. Measurement circuitry determines the flow of the process fluid based upon the upstream process variable and the downstream process variable. | 12-03-2015 |
20160091355 | FLOW MEASUREMENT PROBE - A flow measurement probe includes an elongate probe having an averaging pitot tube with a plurality of upstream and downstream openings arranged along a length of the elongate probe, and a thermal flow measurement sensor coupled to the elongate probe. A method of measuring fluid flow rate in a process includes calculating a flow rate of the fluid using differential pressure in upstream and downstream openings of an averaging pitot tube in an elongate probe when the differential pressure is at least a defined measurement threshold, and calculating the flow rate of the fluid with a thermal mass flow sensor coupled to the flow measurement probe when the differential pressure is less than the defined measurement threshold. | 03-31-2016 |
Patent application number | Description | Published |
20100260230 | IR THERMOMETRY PROBE COVER - A removable protective cover for an insertion probe of a medical instrument. The cover contains a flexible tubular body that compliments the probe geometry and a radially disposed flange that surrounds the proximal end of the body. A series of snap-on fasteners removably connect the cover to the instrument. A camming surface is located on the outer face of the flange which coacts with a cam follower that is movably mounted upon the instrument to flex the cover sufficiently to open the fastener and release the cover from the instrument and move the cover axially toward the distal end of the tip. | 10-14-2010 |
20120027047 | IR THERMOMETRY PROBE COVER - A protective cover for an insertion probe of a medical instrument. The cover contains a flexible tubular body that compliments the probe geometry and a radially disposed flange that surrounds the proximal end of the body. A series of snap-on fasteners removably connect the cover to the instrument. A camming surface is located on the outer face of the flange which coacts with a cam follower that is movably mounted upon the instrument to flex the cover sufficiently to open the fastener and release the cover from the instrument and move the cover axially toward the distal end of the tip. | 02-02-2012 |
20120065473 | DIGITAL OTOSCOPE - An otoscope includes an instrument head, a tip element and an optical system. The instrument head has a distal insertion portion for insertion into an ear of a human or veterinary subject. The distal insertion portion has a distal opening. The tip element is releasably attached to the distal insertion portion. The tip element has a distal opening. The optical system is contained within the instrument head. The optical system includes a plurality of optical components. The optical system further comprises a viewing component for viewing of an image of a target of interest aligned along an optical axis disposed within said distal opening. | 03-15-2012 |
20130267784 | DIGITAL OTOSCOPE - An otoscope includes an instrument head, a tip element and an optical system. The instrument head has a distal insertion portion for insertion into an ear of a human or veterinary subject. The distal insertion portion has a distal opening. The tip element is releasably attached to the distal insertion portion. The tip element has a distal opening. The optical system is contained within the instrument head. The optical system includes a plurality of optical components. The optical system further comprises a viewing component for viewing of an image of a target of interest aligned along an optical axis disposed within said distal opening. The optical system is configured to provide a field of having a diameter equaling at least 7 mm at a distance of at least 15 mm from a distal opening of said attached tip element. The optical system is further configured to simultaneously provide a distance range of optimal focus having a range of at least 8 mm. The distance range of optimal focus includes a location at a working distance equal to about 30 mm. | 10-10-2013 |
Patent application number | Description | Published |
20080223158 | Ratchet Reset Mechanism - A ratchet apparatus includes a first member, a rack, and a second member that is selectively movable in first and second directions with respect to the first member. A first pawl is mounted with respect to the first member and is biased into engagement with the rack. The first pawl and the rack are configured such that engagement of the first pawl with the rack prevents movement of the first pawl relative to the rack in the first direction. A second pawl is mounted with respect to the second member for movement therewith in the first and second directions. The second pawl is biased into engagement with the rack. The second pawl and said rack are configured such that engagement of the second pawl with the rack prevents movement of the second pawl relative to the rack in the first direction. | 09-18-2008 |
20080302024 | Tunable impedance load-bearing structures - A tunable impedance load bearing structure includes a support comprising an active material configured for supporting a load, wherein the active material undergoes a change in a property upon exposure to an activating condition, wherein the change in the property is effective to change an impedance characteristic of the support. | 12-11-2008 |
20090206581 | Airbag System - An embodiment of an airbag system includes a cavity configured to store an airbag, wherein the cavity has an aperture that provides an outlet for the airbag during deployment. The embodiment also includes a cover releasably attached over the aperture via an attachment mechanism having an initial attachment strength. The initial attachment strength is configured to reduce to a release attachment strength in response to receipt of a release signal at the attachment mechanism. | 08-20-2009 |
20090277169 | OVERHEATING PROTECTION FOR SHAPE MEMORY ALLOY ACTUATORS - An overheating protection system adapted for use with a shape memory alloy actuator element, includes at least one switching shape memory alloy element presenting a slower activation period than that of the actuator element, and configured to selectively prevent activation of the actuator element, when the actuator element is actually or predicted to be experiencing overheating; and a circuit comprising the system, wherein the switching element and/or a circuit implement functions to modify activation of the actuator element. | 11-12-2009 |
20110061310 | TUNABLE IMPEDANCE LOAD-BEARING STRUCTURES - A tunable impedance load bearing structure includes a support comprising an active material configured for supporting a load, wherein the active material undergoes a change in a property upon exposure to an activating condition, wherein the change in the property is effective to change an impedance characteristic of the support. | 03-17-2011 |
20120161921 | TUNABLE IMPEDANCE LOAD-BEARING STRUCTURES - A tunable impedance load bearing structure includes a support comprising an active material configured for supporting a load, wherein the active material undergoes a change in a property upon exposure to an activating condition, wherein the change in the property is effective to change an impedance characteristic of the support. | 06-28-2012 |
20130199172 | ACTIVE MATERIAL ELEMENTS HAVING REINFORCED STRUCTURAL CONNECTORS - A load-carrying active material assembly and a method of preparing such an active material assembly suitable for attachment to a movable component of a mechanism is described. The assembly includes a shape memory alloy (SMA) element, a connector adapted to engage the moveable component mechanically crimped to the SMA element, and a filler material disposed intermediate the connector and SMA element. The filler may be a solder or a polymer. Methods for appropriately distributing the filler material and for promoting good adhesion of the filler to the SMA element and the connector are described. | 08-08-2013 |
Patent application number | Description | Published |
20130131529 | SENSING ZONE FOR SPATIALLY RELEVANT ELECTRICAL INFORMATION - Systems and methods are disclosed to determine one or more sensing zones on a body surface for electrocardiographic mapping of a region of interest associated with the heart. The sensing zone can be utilized to facilitate acquisition, processing and mapping of electrical activity for the corresponding region of interest. In other examples, an application-specific arrangement of electrodes can also be provided based on the sensing zone that is determined for the region of interest. | 05-23-2013 |
20130245473 | SYSTEM AND METHODS FOR ASSESSING HEART FUNCTION - Systems and methods can be used to provide an indication of heart function, such as an indication of mechanical function or hemodynamics of the heart, based on electrical data. For example, a method for assessing a function of the heart can include determining a time-based electrical characteristic for a plurality of points distributed across a spatial region of the heart. The plurality of points can be grouped into at least two subsets of points based on at least one of a spatial location for the plurality of points or the time-based electrical characteristics for the plurality of points. An indication of synchrony for the heart can be quantified based on relative analysis of the determined time-based electrical characteristic for each of the at least two subsets of points. | 09-19-2013 |
20140135866 | SYSTEM AND METHODS TO FACILITATE PROVIDING THERAPY TO A PATIENT - A method can include providing ( | 05-15-2014 |
20150335259 | SYSTEM AND METHODS FOR ASSESSING HEART FUNCTION - Systems and methods can be used to provide an indication of heart function, such as an indication of mechanical function or hemodynamics of the heart, based on electrical data. For example, a method for assessing a function of the heart can include determining a time-based electrical characteristic for a plurality of points distributed across a spatial region of the heart. The plurality of points can be grouped into at least two subsets of points based on at least one of a spatial location for the plurality of points or the time-based electrical characteristics for the plurality of points. An indication of synchrony for the heart can be quantified based on relative analysis of the determined time-based electrical characteristic for each of the at least two subsets of points. | 11-26-2015 |
Patent application number | Description | Published |
20130304407 | CHANNEL INTEGRITY DETECTION - A computer-implemented method can include determining an amplitude for each of a plurality of input channels, corresponding to respective nodes. A measure of similarity can be computed between the input channel of each node and the input channel of its neighboring nodes. The method can also include comparing an amplitude for each node relative to other nodes to determine temporary bad channels. For each of the temporary bad channels, a measure of similarity can be computed between the input channel of each node and the input channel of its neighboring nodes. Channel integrity can then be identified based on the computed measures of similarity. | 11-14-2013 |
20140088395 | PHYSIOLOGICAL MAPPING FOR ARRHYTHMIA - A non-transitory computer-readable medium can have instructions executable by a processor. The instructions can include an electrogram reconstruction method to generate reconstructed electrogram signals for each of a multitude of points residing on or near a predetermined cardiac envelope based on geometry data and non-invasively measured body surface electrical signals. The instructions can include a phase calculator to compute phase signals for the multitude of points based on the reconstructed electrogram signals and a visualization engine to generate an output based on the computed phase signals. | 03-27-2014 |
20140200467 | COMPOSITE SINGULARITY MAPPING - A method can include storing a plurality of data sets including values computed for each of a plurality of points for a given spatial region of tissue, the values in each of the data sets characterizing electrical information for each respective point of the plurality of points for a different time interval. The method can also include combining the values computed for each of a plurality of points in a first interval, corresponding to a first map, with the values for computed for each of the respective plurality of points in another interval and to normalize the combined values relative to a common scale. The method can also include generating a composite map for the given spatial region based on the combined values that are normalized. | 07-17-2014 |
20140200473 | FOCAL POINT IDENTIFICATION AND MAPPING - A method can determine one or more origins of focal activation. The method can include computing phase for the electrical signals at a plurality of nodes distributed across a geometric surface based on the electrical data across time. The method can determine whether or not a given candidate node of the plurality of nodes is a focal point based on the analyzing the computed phase and magnitude of the given candidate node. A graphical map can be generated to visualize focal points detected on the geometric surface. | 07-17-2014 |
20140336520 | ANALYSIS AND DETECTION FOR ARHYTHMIA DRIVERS - Systems and methods are provided to detect and analyze arrhythmia drivers. In one example, a system can include a wave front analyzer programmed to compute wave front lines extending over a surface for each of the plurality of time samples based on phase information computed from electrical data at nodes distributed across the surface. A trajectory detector can be programmed to compute wave break points for each of the wave front lines and to determine a trajectory of at least one rotor core across the surface. A stability detector can be programmed to identify at least one stable rotor portion corresponding to subtrajectories of the determined trajectory. | 11-13-2014 |
20150216435 | SIGNAL ANALYSIS RELATED TO TREATMENT SITES - A method includes storing baseline data representing at least one local or global electrical characteristics for at least a portion of a region of interest (ROI) of a patient's anatomical structure. The baseline data is determined based on electrical measurement data obtained during at least one first measurement interval. The method also includes storing in memory other data representing the at least one local or global electrical characteristics for the at least a portion of the ROI based on electrical measurement data obtained during at least one subsequent measurement interval. The method also includes evaluating the baseline data relative to the other data to determine a change in the at least one local or global electrical characteristics. The method also includes generating an output based on the evaluating to provide an indication of progress or success associated with the applying the treatment. | 08-06-2015 |
20150216438 | INTEGRATED ANALYSIS OF ELECTROPHYSIOLOGICAL DATA - A method can include analyzing non-invasive electrical data for a region of interest (ROI) of a patient's anatomical structure to identify one or more zones within the ROI that contain at least one mechanism of distinct arrhythmogenic electrical activity. The method also includes analyzing invasive electrical data for a plurality of signals of interest at different spatial sites within each of the identified zones to determine intracardiac signal characteristics for the plurality of sites within each respective zone. The method also includes generating an output that integrates the at least one mechanism of distinct arrhythmogenic electrical activity for the one or more zones with intracardiac signal characteristics for the plurality of sites within each respective zone. | 08-06-2015 |
20160067489 | SYSTEM AND METHODS TO FACILITATE PROVIDING THERAPY TO A PATIENT - A system can include a sensor array comprising a plurality of sensors configured to measure electrical activity across a body surface of a patient and generate electrical data characterizing the measured electrical activity. The plurality of sensors are arranged at predetermined locations for placement over the patient's body to define at least one predetermined zone of the patient's body that maps deterministically to at least one predetermined region of interest of at least one internal anatomical structure of the patient. A control system is configured to analyze the electrical data for the at least one predetermined zone to provide a surrogate estimate of electrical activity at the at least one predetermined region of interest. The control system also is configured to control delivery of a therapy to the patient based on the surrogate estimate of electrical activity at the at least one predetermined region of interest. | 03-10-2016 |
Patent application number | Description | Published |
20080270838 | DISTRIBUTED, FAULT-TOLERANT AND HIGHLY AVAILABLE COMPUTING SYSTEM - A method and system for achieving highly available, fault-tolerant execution of components in a distributed computing system, without requiring the writer of these components to explicitly write code (such as entity beans or database transactions) to make component state persistent. It is achieved by converting the intrinsically non-deterministic behavior of the distributed system to a deterministic behavior, thus enabling state recovery to be achieved by advantageously efficient checkpoint-replay techniques. The method comprises: adapting the execution environment for enabling message communication amongst and between the components; automatically associating a deterministic timestamp in conjunction with a message to be communicated from a sender component to a receiver component during program execution, the timestamp representative of estimated time of arrival of the message at a receiver component. At a component, tracking state of that component during program execution, and periodically checkpointing the state in a local storage device. Upon failure of a component, the component state is restored by recovering a recent stored checkpoint and re-executing the events occurring since the last checkpoint. The system is deterministic by repeating the execution of the receiving component by processing the messages in the same order as their associated timestamp. | 10-30-2008 |
20110023050 | SYSTEM AND METHOD FOR TIME-AWARE RUN-TIME TO GUARANTEE TIME - A method and system for achieving time-awareness in the highly available, fault-tolerant execution of components in a distributed computing system, without requiring the writer of these components to explicitly write code (such as entity beans or database transactions) to make component state persistent. It is achieved by converting the intrinsically non-deterministic behavior of the distributed system to a deterministic behavior, thus enabling state recovery to be achieved by advantageously efficient checkpoint-replay techniques. The system is deterministic by repeating the execution of the receiving component by processing the messages in the same order as their associated timestamps and time-aware by allowing adjustment of message execution based on time. | 01-27-2011 |
20130212592 | SYSTEM AND METHOD FOR TIME-AWARE RUN-TIME TO GUARANTEE TIMELINESS IN COMPONENT-ORIENTED DISTRIBUTED SYSTEMS - A method and system for achieving time-awareness in the highly available, fault-tolerant execution of components in a distributed computing system, without requiring the writer of these components to explicitly write code (such as entity beans or database transactions) to make component state persistent. It is achieved by converting the intrinsically non-deterministic behavior of the distributed system to a deterministic behavior, thus enabling state recovery to be achieved by advantageously efficient checkpoint-replay techniques. The system is deterministic by repeating the execution of the receiving component by processing the messages in the same order as their associated timestamps and time-aware by allowing adjustment of message execution based on time. | 08-15-2013 |
Patent application number | Description | Published |
20130054304 | METHOD OF ANALYZING A SALE PROCESS FOR AN ENTITY - A computer-implemented method determines determine an adequacy of a process to sell an entity responsive to competition, fairness, thoroughness, and good faith. A computer evaluates a sale of an entity by rating solicitation efforts associated with potential buyers of the entity (audience), by rating information about the entity prepared for potential buyers, by rating time frames surrounding the sale (timing), by rating circumstances associated with a transfer of the entity, and by rating a negotiation and execution efforts associated with the sale of the entity. Each criteria investigated is provided a weighting factor, where the weighting factor for the audience and transfer is around 0.25, the factor for the information and negotiation and execution is around 0.20, and the weighting factor for the timing is around 0.10. | 02-28-2013 |
20140136369 | Method of Analyzing a Sale Process for an Entity - A computer-implemented method determines determine an adequacy of a process to sell an entity responsive to competition, fairness, thoroughness, and good faith. A computer evaluates a sale of an entity by rating solicitation efforts associated with potential buyers of the entity (audience), by rating information about the entity prepared for potential buyers, by rating time frames surrounding the sale (timing), by rating circumstances associated with a transfer of the entity, and by rating a negotiation and execution efforts associated with the sale of the entity. Each criteria investigated is provided a weighting factor, where the weighting factor for the audience and transfer is around 0.25, the factor for the information and negotiation and execution is around 0.20, and the weighting factor for the timing is around 0.10. | 05-15-2014 |
Patent application number | Description | Published |
20110045002 | METHODS OF MODULATING IMMUNE RESPONSES BY MODULATING TIM-1, TIM-2 AND TIM-4 FUNCTION - The invention relates to methods of modulating immune responses in a subject, such as by administering to the subject agents which modulate tim-1, tim-2 or tim-4 activity, or which modulate the physical interaction between tim-1 and tim-4 or between tim-2 and a tim-2 ligand. Immune responses include, but are not limited to, autoimmune disorders, transplantation tolerance, and Th1 and Th2-mediated responses and disorders. The invention also relates to novel assays for identifying agents which modulate the physical interaction between tim-1 and tim-4. In addition, the invention relates to novel soluble tim-4 polypeptides and to nucleic acids which encode them. | 02-24-2011 |
20130183688 | TIM-3 LIGANDS AND METHODS THEREOF - The invention relates to isolated polypeptides and nucleic acids encoding polypeptides which comprise a tim-3 IgV domain and a tim-3 intracellular domain, wherein the polypeptides do not comprise a tim-3 mucin domain or a tim-3 transmembrane domain. In addition, the invention relates to methods of modulating immune responses in a subject, comprising administering to the subject a therapeutically effective amount of an agent that modulates tim-3 activity. Immune responses include, but are not limited to, immune tolerance, transplantation tolerance, Th1 responses and Th2 responses. | 07-18-2013 |
20130195895 | METHODS OF MODULATING IMMUNE RESPONSES BY MODULATING TIM-1, TIM-2 AND TIM-4 FUNCTION - The invention relates to methods of modulating immune responses in a subject such as by administering to the subject agents which modulate tim-1, tim-2 or tim-4 activity, or which modulate the physical interaction between tim-1 and tim-4 or between tim-2 and a tim-2 ligand. Immune responses include, but are not limited to, autoimmune disorders, transplantation tolerance, and Th1 and Th2-mediated responses and disorders. The invention also relates to novel assays for identifying agents which modulate the physical interaction between tim-1 and tim-4. In addition, the invention relates to novel soluble tim-4 polypeptides and to nucleic acids which encode them. | 08-01-2013 |
20130224109 | COMPOSITIONS AND METHODS FEATURING IL-6 AND IL-21 ANTAGONISTS - The present invention features compositions for inhibiting both the IL-6 and the IL-21 pathways and methods of making and using such compositions. Our work to date indicates the importance of the redundancy of IL-6 and IL-21 to perform certain crucial functions. The pathways can be inhibited by inhibiting the ligands (i.e., IL-6 and IL-21) and/or their respective receptors (i.e., the IL-6 receptor and IL-21 receptor). Alternatively, or in addition, upstream and downstream effectors in the IL-6 and IL-21 pathways can be blocked. The agents used can be antibody or antibody-based proteins or peptides including circulating receptors, optionally coupled to an immunoglobulin or a portion thereof (e.g., the Fc region). Also provided are methods for using the compositions, for example, in organ transplantation, tissue grafting, or autoimmune disorders. | 08-29-2013 |
20140348842 | TIM-3 LIGANDS AND METHODS THEREOF - The invention relates to isolated polypeptides and nucleic acids encoding polypeptides which comprise a tim-3 IgV domain and a tim-3 intracellular domain, wherein the polypeptides do not comprise a tim-3 mucin domain or a tim-3 transmembrane domain. In addition, the invention relates to methods of modulating immune responses in a subject, comprising administering to the subject a therapeutically effective amount of an agent that modulates tim-3 activity. Immune responses include, but are not limited to, immune tolerance, transplantation tolerance, Th1 responses and Th2 responses. | 11-27-2014 |
20150079085 | METHODS OF MODULATING IMMUNE RESPONSES BY MODULATING TIM-1, TIM-2 AND TIM-4 FUNCTION - The invention relates to methods of modulating immune responses in a subject such as by administering to the subject agents which modulate tim-1, tim-2 or tim-4 activity, or which modulate the physical interaction between tim-1 and tim-4 or between tim-2 and a tim-2 ligand. Immune responses include, but are not limited to, autoimmune disorders, transplantation tolerance, and Th1 and Th2-mediated responses and disorders. The invention also relates to novel assays for identifying agents which modulate the physical interaction between tim-1 and tim-4. In addition, the invention relates to novel soluble tim-4 polypeptides and to nucleic acids which encode them. | 03-19-2015 |
Patent application number | Description | Published |
20100111940 | COMPOSITIONS CONTAINING ALPHA-1-ANTITRYPSIN AND METHODS FOR USE - Methods and compositions for treating patients (e.g., patients who are insulin resistant, patients who have diabetes, or are at risk for developing diabetes) are disclosed herein. The methods can include administration of an a1 antitrypsin (AAT) polypeptide or an agent, such as a nucleic acid molecule or organic compound, that promotes the expression or activity of a1-antitrypsin. | 05-06-2010 |
20110020269 | METHODS AND COMPOSITIONS FOR MODIFYING T CELL IMMUNE RESPONSES AND INFLAMMATION - Methods and compositions for immune modulation are described herein. The compositions encompass pharmaceutical compositions that include a combination of agents. The first agent can selectively stimulate regulatory T cells or selectively inhibit inflammatory T cells and the second agent can reduce an inflammatory response in a tissue of a patient to whom the composition is administered. The second agent can reduce the expression or activity of a pro-inflammatory cytokine, promote the expression or activity of an anti-inflammatory cytokine, or both. | 01-27-2011 |
20110020367 | Methods of Evaluating Transplant Rejection - The invention relates to methods of evaluating transplant rejection in a host comprising determining a heightened magnitude of gene expression of genes in rejection-associated gene clusters. The disclosed gene clusters include genes that are substantially co-expressed with cytotoxic lymphocyte pro-apoptotic genes, cytoprotective genes and several other cytokine and immune cell genes. | 01-27-2011 |
20130040301 | Methods of Evaluating Transplant Rejection - The invention relates to methods of evaluating transplant rejection in a host comprising determining a heightened magnitude of gene expression of genes in rejection-associated gene clusters. The disclosed gene clusters include genes that are substantially co-expressed with cytotoxic lymphocyte pro-apoptotic genes, cytoprotective genes and several other cytokine and immune cell genes. | 02-14-2013 |
20140147441 | COMPOSITIONS CONTAINING ALPHA-1-ANTITRYPSIN AND METHODS FOR USE - Methods and compositions for treating patients (e.g., patients who are insulin resistant, patients who have diabetes, or are at risk for developing diabetes) are disclosed herein. The methods can include administration of an α1 antitrypsin (AAT) polypeptide or an agent, such as a nucleic acid molecule or organic compound, that promotes the expression or activity of α1-antitrypsin. | 05-29-2014 |
20140303251 | Methods Of Treating Acute Kidney Injury With Retinoic Acid - The present invention provides, in one embodiment, a method of inhibiting apoptosis in kidney epithelial cells after acute injury by modulating/inhibiting Nur77 induction/expression or function/activity in the cells. The invention further provides a method of preventing or treating an acute kidney injury in a subject in need thereof, comprising administering to the subject an effective amount of a retinoic acid or retinoic acid derivative, and a method of preserving a kidney for transplant, comprising contacting the kidney with a solution that comprises a retinoic acid or a, retinoic acid derivative. | 10-09-2014 |