Patent application number | Description | Published |
20130224872 | Apparatus and Methods for Detecting Propellant Degradation in Solid Propellant Fuel - The present disclosure relates to a gas sensor, including: a gas collecting chamber including: (a) a nanoporous wall including alumina, on a portion of the gas collecting chamber in the near vicinity of the solid propellant fuel; a micro pump attached to the gas collecting chamber; and a gas analysis device connected to the gas collecting chamber. The gas analysis device measures both type and concentration of gases collected in the gas collecting chamber via the nanoporous wall, the gases measured being selected from the group consisting of CO, CO | 08-29-2013 |
20140022551 | System and Method for Detecting the Amount of Stabilizer Degradation in Solid Rocket Propellant - A spectrometric system, including: a solid rocket fuel; an illuminating source including at least two wavelengths within a spectral range from 100 nm to 200,000 nm, a first wavelength or range of wavelengths having a distinguishably greater or lesser absorbance for the stabilizer than for components of the propellant, and a second wavelength or range of wavelengths having an absorbance for the stabilizer not distinguishably different than the absorbance for the components of the propellant, an illuminating fiber to illuminate a surface of a solid rocket fuel; a collecting fiber to collect back scattered, reflected or transmitted light being given off from the surface of the solid rocket fuel; and a spectrometer to determine the light intensities of the two wavelengths of the back scattered, reflected or transmitted light collected. | 01-23-2014 |
20140246589 | Apparatus and Methods for Detecting Propellant Degradation in Solid Propellant Fuel - The present disclosure relates to a gas sensor, including: a gas collecting chamber including: (a) a nanoporous wall including alumina, on a portion of the gas collecting chamber in the near vicinity of the solid propellant fuel; a micro pump attached to the gas collecting chamber; and a gas analysis device connected to the gas collecting chamber. The gas analysis device measures both type and concentration of gases collected in the gas collecting chamber via the nanoporous wall, the gases measured being selected from the group consisting of CO, CO | 09-04-2014 |
Patent application number | Description | Published |
20090004658 | INTEGRIN ALPHA 7 MUTATIONS IN PROSTATE CANCER, LIVER CANCER, GLIOBLASTOMA MULTIFORME, AND LEIOMYOSARCOMA - Methods are provided for determining the presence of a cancer in a biological sample, such as a tissue biopsy. The methods comprise determining if integrin alpha 7 expression is decreased in the biopsy which is indicative of the presence of a cancer or likelihood of relapse of a cancer. This can be accomplished by determining if levels of integrin alpha 7 mRNA or protein are decreased as compared to a control. This also can be accomplished by determining if a mutation in the integrin alpha 7 gene is present in the biopsy. | 01-01-2009 |
20130079241 | Methods for Diagnosing Prostate Cancer and Predicting Prostate Cancer Relapse - The present invention relates to methods and compositions for diagnosing prostate cancer and/or determining whether a prostate cancer patient is at increased risk of suffering a relapse, or a rapid relapse, of his cancer. It is based, at least in part, on the results of a comprehensive genome analysis on 241 prostate cancer samples (104 prostate cancer, 85 matched bloods, 49 matched benign prostate tissues adjacent to cancer, and 3 cell lines) which indicate that (i) genome copy number variation (CNV) occurred in both cancer and non-cancer tissues, and (ii) CNV predicts prostate cancer progression. | 03-28-2013 |
20150050647 | Methods for Diagnosing Prostate Cancer and Predicting Prostate Cancer Relapse - The present invention relates to methods and compositions for diagnosing prostate cancer and/or determining whether a prostate cancer patient is at increased risk of suffering a relapse, or a rapid relapse, of his cancer. It is based, at least in part, on the results of a comprehensive genome analysis on 241 prostate cancer samples (104 prostate cancer, 85 matched bloods, 49 matched benign prostate tissues adjacent to cancer, and 3 cell lines) which indicate that (i) genome copy number variation (CNV) occurred in both cancer and non-cancer tissues, and (ii) CNV predicts prostate cancer progression. | 02-19-2015 |
Patent application number | Description | Published |
20080287627 | Perfluoroelastomer compositions and methods of preparing same - The present invention includes crosslinked perfluoroelastomeric compositions and molded articles formed from a cross-linkable perfluoroelastomeric composition having a first curable perfluoropolymer having a cure site monomer and a second perfluoropolymer having a cure site monomer. The molar ratio of the tetrafluoroethylene monomer to perfluoroalkylvinyl ether in one perfluoropolymer is about 0 to 100 to about 65 to 35 in the perfluoropolymer. The molar ratio of the tetrafluoroethylene monomer to the perfluoroalkylvinyl ether monomer in the second polymer is about 65:35 to about 95:5 in the second perfluoropolymer. The composition further includes a curative. One fluorine-containing elastomer composition herein, having a short crosslinking time, has perfluoroelastomers (A) having a tetrafluoroethylene unit, a perfluoralkylvinyl ether unit (a) and a monomer unit (b) having at least one kind selected from the group consisting of a nitrile group, a carboxyl group and an alkoxycarbonyl group, wherein the composition has two or more kinds of perfluoroelastomers (A) having differing contents of perfluoroalkylvinyl ether unit (a). | 11-20-2008 |
20100151254 | Perfluoroelastomer Compositions Including Barium Titanate Fillers - Provided herein is a fluorine-containing elastomer composition having a first curable perfluoropolymer comprising tetrafluoroethylene, at least one perfluoroalkylvinyl ether and at least one cure site monomer having a functional group to permit crosslinking of the perfluoropolymer; and barium titanate. | 06-17-2010 |
20110086229 | PERFLUOROELASTOMER COMPOSITIONS AND METHODS OF PREPARING SAME - The present invention includes crosslinked perfluoroelastomeric compositions and molded articles formed from a cross-linkable perfluoroelastomeric composition having a first curable perfluoropolymer having a cure site monomer and a second perfluoropolymer having a cure site monomer. The molar ratio of the tetrafluoroethylene monomer to perfluoroalkylvinyl ether in one perfluoropolymer is about 0 to 100 to about 65 to 35 in the perfluoropolymer. The molar ratio of the tetrafluoroethylene monomer to the perfluoroalkylvinyl ether monomer in the second polymer is about 65:35 to about 95:5 in the second perfluoropolymer. The composition further includes a curative. One fluorine-containing elastomer composition herein, having a short crosslinking time, has perfluoroelastomers (A) having a tetrafluoroethylene unit, a perfluoralkylvinyl ether unit (a) and a monomer unit (b) having at least one kind selected from the group consisting of a nitrile group, a carboxyl group and an alkoxycarbonyl group, wherein the composition has two or more kinds of perfluoroelastomers (A) having differing contents of perfluoroalkylvinyl ether unit (a). | 04-14-2011 |
20110236692 | FLUOROELASTOMER COMPOSITIONS HAVING SELF-BONDING CHARACTERISTICS AND METHODS OF MAKING SAME - Self-bonding curable fluoroelastomer compositions are provided wherein the compositions including a) a fluoropolymer composition having at least one curable fluoropolymer; and b) a compound selected from the group consisting of aluminum acrylates, silicon acrylates, and ammonia acrylates, wherein the self-bonding curable fluoroelastomer composition is able to bond directly to a substrate. Bonded structures formed of such self-bonding compositions and a substrate having a surface bonded thereto are also described herein along with a method for bonding a self-bonding curable fluoroelastomer composition to a substrate surface. The fluoroelastomers herein may encompass both non-fully fluorinated (FKM) and fully fluorinated (FFKM) elastomers. | 09-29-2011 |
20120077935 | FLUORINE-CONTAINING ELASTOMER COMPOSITIONS SUITABLE FOR HIGH TEMPERATURE APPLICATIONS - A curable fluorine-containing elastomer composition is described which includes a first curable perfluoropolymer comprising tetrafluoroethylene, a first perfluoroalkylvinyl ether and at least one first cure site monomer having at least one cure site, wherein tetrafluoroethylene is present in the first curable perfluoropolymer in an amount of at least about 50 mole percent; a second curable perfluoropolymer comprising tetrafluoroethylene, a second perfluoroalkylvinyl ether and at least one second cure site monomer having at least one cure site, wherein the second curable perfluoropolymer comprises fluoroplastic particles therein; and at least one curative. Cured compositions and molded articles formed from such compositions are also disclosed. | 03-29-2012 |
20120100379 | FLUOROELASTOMER BONDING COMPOSITIONS SUITABLE FOR HIGH-TEMPERATURE APPLICATIONS - Bonding compositions are provided herein for bonding a curable fluoroelastomer composition, and preferably a perfluoroelastomer composition, to a substrate during a heat curing process. The compositions include (a) a compound selected from the group consisting of aluminum acrylates, silicon acrylates, ammonia acrylates, and combinations thereof, (b) an adhesive compound; and (c) a solvent. Methods of bonding fluoro- and perfluoroelastomers to a substrate surface are also including herein which utilize the bonding compositions. | 04-26-2012 |
20140107280 | Fluoroelastomer Compositions Having Self-Bonding Characteristics and Methods of Making Same - Self-bonding curable fluoroelastomer compositions are provided wherein the compositions including a) a fluoropolymer composition having at least one curable fluoropolymer; and b) a compound selected from the group consisting of aluminum acrylates, silicon acrylates, and ammonia acrylates, wherein the self-bonding curable fluoroelastomer composition is able to bond directly to a substrate. Bonded structures formed of such self-bonding compositions and a substrate having a surface bonded thereto are also described herein along with a method for bonding a self-bonding curable fluoroelastomer composition to a substrate surface. The fluoroelastomers herein may encompass both non-fully fluorinated (FKM) and fully fluorinated (FFKM) elastomers. | 04-17-2014 |
Patent application number | Description | Published |
20120301461 | 1D05 PCSK9 ANTAGONISTS - Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure. | 11-29-2012 |
20140121123 | METHODS FOR DIVERSIFYING ANTIBODIES, ANTIBODIES DERIVED THEREFROM AND USES THEREOF - The invention provides methods of introducing diversity into antibody molecules comprising introducing or substituting at least one amino acid sequence in the CDR of the target antibody together with at least one amino acid in the FW region spanning the 3 amino acid adjoining the CRD on each side. The resulting diverse antibodies with variant CDRs and FW region sequences comprising diverse amino acid sequences are also described. These polypeptides regions, herein referred to as 3+CDR3+, that form the gist of the invention contribution described herein provide a flexible and simple source of sequence diversity that can be used as a source for expressing and identifying diverse antibodies or antigen binding polypeptides. Libraries comprising a plurality of these polypeptides are also provided. In addition, methods of and compositions for generating and using these polypeptides and libraries are provided. A method of producing diverse antibodies comprising amino acid substitutions in one of the CDR region and the FW region comprising 3 contiguous FW sequence amino acids adjacent to each CDR on either side is described herein. The substitutions are relative to database or germline sequences. Not all substitution are preserved in conservative regions. | 05-01-2014 |
20140220027 | 1D05 PCSK9 ANTAGONISTS - Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure. | 08-07-2014 |
Patent application number | Description | Published |
20090232795 | 1B20 PCSK9 ANTAGONISTS - Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure. | 09-17-2009 |
20090246192 | 1D05 PCSK9 antagonists - Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure. | 10-01-2009 |
20130071379 | 1B20 PCSK9 ANTAGONISTS - Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure. | 03-21-2013 |
Patent application number | Description | Published |
20090082221 | Cross-Species and Multi-Species Display Systems - The present invention provides expression vectors and helper display vectors which can be used in various combinations as vector sets for multi-species and cross-species display of polypeptides on the outer surface of prokaryotic genetic packages and/or eukaryotic host cells. The multi-species and cross-species display systems can be practiced using the vector sets of the invention without having to change or reengineer the display vectors. The display systems of the invention are particularly useful for displaying a genetically diverse repertoire or library of polypeptides on the surface of phage, bacterial host cells, yeast cells, and mammalian cells. | 03-26-2009 |
20090136523 | ANTI-CD26 ANTIBODIES AND METHODS OF USE THEREOF - The present invention provides novel anti-CD26 antibodies and other, related polypeptides, as well as novel polynucleotides encoding the antibodies and polypeptides. The invention also provides methods of making the antibodies and polypeptides. Compositions and cells comprising the antibodies or polypeptides are further provided. Methods of using the antibodies and/or polypeptides, such as to inhibit cell proliferation and in the treatment of conditions associated with CD26, are also provided. | 05-28-2009 |
20090163379 | Eukaryotic cell display systems - The present invention provides expression vectors and helper display vectors which can be used in various combinations as vector sets for display of polypeptides on the outer surface of eukaryotic host cells. The expression vector of the invention can be used alone for soluble expression without having to change or reengineer the display vectors. The display systems of the invention are particularly useful for displaying a genetically diverse repertoire or library of polypeptides on the surface of yeast cells, and mammalian cells. | 06-25-2009 |
20120213794 | AX213 AND AX132 PSCK9 ANTAGONISTS AND VARIANTS - Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure. | 08-23-2012 |
20120231005 | AX1 AND AX189 PSCK9 ANTAGONISTS AND VARIANTS - Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure. | 09-13-2012 |
20120329679 | EUKARYOTIC CELL DISPLAY SYSTEMS - The present invention provides expression vectors and helper display vectors which can be used in various combinations as vector sets for display of polypeptides on the outer surface of eukaryotic host cells. The expression vector of the invention can be used alone for soluble expression without having to change or reengineer the display vectors. The display systems of the invention are particularly useful for displaying a genetically diverse repertoire or library of polypeptides on the surface of yeast cells, and mammalian cells. | 12-27-2012 |
Patent application number | Description | Published |
20100144389 | CORDLESS TELEPHONE WITH MP3 PLAYER CAPABILITY - A cordless telephone which allows a user to play MP3 digital audio bit stream music, a video game, either alone or with a user of another cordless telephone, using the remote handset of a cordless telephone to control the functions of the MP3 player. The cordless telephone remains usable as a typical cordless telephone with all the features and conveniences of a cordless telephone including, but not limited to, connection of a telephone call between a calling party and a called party, caller ID information, voice messaging features, etc. MP3 digital audio bit stream music may be downloaded from a remote source through, e.g., the Internet and a PC. | 06-10-2010 |
20110201384 | Cordless Telephone with Digital Audio Player Capability - A cordless telephone which allows a user to play MP3 digital audio bit stream music, using the remote handset of a cordless telephone to control the functions of the MP3 player. The cordless telephone remains usable as a typical cordless telephone with all the features and conveniences of a cordless telephone including, but not limited to, connection of a telephone call between a calling party and a called party, caller ID information, voice messaging features, etc. MP3 digital audio bit stream music may be downloaded from a remote source through, e.g., the Internet and a PC. | 08-18-2011 |
20120225689 | Cordless Telephone With Digital Audio Player Capability - A cordless telephone which allows a user to play MP3 digital audio bit stream music, using the remote handset of a cordless telephone to control the functions of the MP3 player. The cordless telephone remains usable as a typical cordless telephone with all the features and conveniences of a cordless telephone including, but not limited to, connection of a telephone call between a calling party and a called party, caller ID information, voice messaging features, etc. MP3 digital audio bit stream music may be downloaded from a remote source through, e.g., the Internet and a PC. | 09-06-2012 |
Patent application number | Description | Published |
20080279746 | Process for the Fluorination of Boron Hydrides - A process for fluorination of borohydride salts including providing a reaction medium comprising HF and a superacid. A borohydride salt compound is added to the reaction medium. The borohydride salt is reacted with the with the reaction medium under conditions to form a fluorinated borohydride salt. In addition, reactor vessels may be provided for reacting the HF, superacid additive and borohydride that are fabricated from materials resistant to superacid compositions. | 11-13-2008 |
20140033762 | Heavy Hydrocarbon Removal From A Natural Gas Stream - A method and apparatus of removing heavy hydrocarbons from a natural gas feed stream, the method comprising using first and second hydrocarbon removal systems in series such that the first system processes the natural gas feed stream to produce a heavy hydrocarbon depleted natural gas stream and the second system processes at least a portion of the heavy hydrocarbon depleted natural gas stream from the first system to produce a natural gas stream lean in heavy hydrocarbons, wherein one of said systems is a adsorption system that comprises one or more beds of adsorbent for adsorbing and thereby removing heavy hydrocarbons from a heavy hydrocarbon containing natural gas, and the other of said systems is a gas-liquid separation system for separating a heavy hydrocarbon containing natural gas into a heavy hydrocarbon depleted natural gas vapor and a heavy hydrocarbon enriched liquid. | 02-06-2014 |
20140033763 | Heavy Hydrocarbon Removal From A Natural Gas Stream - A method and apparatus of removing heavy hydrocarbons from a natural gas feed stream, the method comprising using first and second hydrocarbon removal systems in series such that the first system processes the natural gas feed stream to produce a heavy hydrocarbon depleted natural gas stream and the second system processes at least a portion of the heavy hydrocarbon depleted natural gas stream from the first system to produce a natural gas stream lean in heavy hydrocarbons, wherein one of said systems is a adsorption system that comprises one or more beds of adsorbent for adsorbing and thereby removing heavy hydrocarbons from a heavy hydrocarbon containing natural gas, and the other of said systems is a gas-liquid separation system for separating a heavy hydrocarbon containing natural gas into a heavy hydrocarbon depleted natural gas vapor and a heavy hydrocarbon enriched liquid. | 02-06-2014 |