Patent application number | Description | Published |
20090082213 | CONSTRUCTION OF DIVERSE SYNTHETIC PEPTIDE AND POLYPEPTIDE LIBRARIES - The present invention concerns the design and construction of diverse peptide and polypeptide libraries. In particular, the invention concerns methods of analytical database design for creating datasets using multiple relevant parameters as filters, and methods for generating sequence diversity by directed multisyntheses oligonucleotide synthesis. The present methods enable the reduction of large complex annotated databases to simpler datasets of related sequences, based upon relevant single or multiple key parameters that can be individually directly defined. The methods further enable the creation of diverse libraries based on this approach, using multisynthetic collections of discrete and degenerate oligonucleotides to capture the diverse collection of sequences, or portions thereof. | 03-26-2009 |
20100004134 | Combinatorial libraries of conformationally constrained polypeptide sequences - The present invention concerns combinatorial libraries of conformationally constrained polypeptide sequences and their uses. In particular, the present invention concerns combinatorial libraries of conformational epitopes and their uses. | 01-07-2010 |
20120129731 | Design and construction of diverse synthetic peptide and polypeptide libraries - The present invention concerns the design and construction of diverse peptide and polypeptide libraries. In particular, the invention concerns methods of analytical database design for creating datasets using multiple relevant parameters as filters, and methods for generating sequence diversity by directed multisyntheses oligonucleotide synthesis. The present methods enable the reduction of large complex annotated databases to simpler datasets of related sequences, based upon relevant single or multiple key parameters that can be individually directly defined. The methods further enable the creation of diverse libraries based on this approach, using multisynthetic collections of discrete and degenerate oligonucleotides to capture the diverse collection of sequences, or portions thereof. | 05-24-2012 |
20120202716 | Construction of diverse synthetic peptide and polypeptide libraries - The present invention concerns the design and construction of diverse peptide and polypeptide libraries. In particular, the invention concerns methods of analytical database design for creating datasets using multiple relevant parameters as filters, and methods for generating sequence diversity by directed multisyntheses oligonucleotide synthesis. The present methods enable the reduction of large complex annotated databases to simpler datasets of related sequences, based upon relevant single or multiple key parameters that can be individually directly defined. The methods further enable the creation of diverse libraries based on this approach, using multisynthetic collections of discrete and degenerate oligonucleotides to capture the diverse collection of sequences, or portions thereof. | 08-09-2012 |
20130288900 | COMBINATORIAL LIBRARIES OF CONFORMATIONALLY CONSTRAINED POLYPEPTIDE SEQUENCES - The present invention concerns combinatorial libraries of conformationally constrained polypeptide sequences and their uses. In particular, the present invention concerns combinatorial libraries of conformational epitopes and their uses. | 10-31-2013 |
Patent application number | Description | Published |
20110308974 | Packaged, Wrapped, Cylindrically Rolled Moisture-Sensitive Film and Method of Making the Same - A method for packaging a wrapped, moisture-sensitive, cylindrically rolled film by positioning along an alignment axis, a wrapped, rolled moisture-sensitive film, a funneling guide, a tube, and an extendible rod that includes a support head. The method comprises the steps of extending the rod through the tube while simultaneously and while maintaining the alignment of the wrapped film, funneling guide, tube and rod, tilting the alignment axis from a first position to a second position such that the wrapped film enters and moves through the funneling guide, and the wrapped film contacts the support head of the rod, retracting the rod such that the wrapped film enters the tube through the funneling guide, and while maintaining the alignment of the wrapped film, funneling guide, tube and rod the alignment axis, tilting from the second position to the first position and retracting the rod from the tube. | 12-22-2011 |
Patent application number | Description | Published |
20080199442 | Methods for delivering DNA to muscle cells using recombinant adeno-associated virus vectors - The use of recombinant adeno-associated virus (AAV) virions for delivery of DNA molecules to muscle cells and tissue is disclosed. The invention allows for the direct, in vivo injection of recombinant AAV virions into muscle tissue, e.g., by intramuscular injection, as well as for the in vitro transduction of muscle cells which can subsequently be introduced into a subject for treatment. The invention provides for sustained, high-level expression of the delivered gene and for in vivo secretion of the therapeutic protein from transduced muscle cells such that systemic delivery is achieved. | 08-21-2008 |
20080305084 | Methods for delivering DNA to muscle cells using recombinant adeno-associated virus virions - The use of recombinant adeno-associated virus (AAV) virions for delivery of DNA molecules to muscle cells and tissue is disclosed. The invention allows for the direct, in vivo injection of recombinant AAV virions into muscle tissue, e.g., by intramuscular injection, as well as for the in vitro transduction of muscle cells which can subsequently be introduced into a subject for treatment. The invention provides for sustained, high-level expression of the delivered gene and for in vivo secretion of the therapeutic protein from transduced muscle cells such that systemic delivery is achieved. | 12-11-2008 |
20100104535 | Methods of treating anemia using recombinant adeno-associated virus virions - The use of recombinant adeno-associated virus (AAV) virions for delivery of DNA molecules to muscle cells and tissue in the treatment of anemia is disclosed. The invention allows for the direct, in vivo injection of recombinant AAV virions into muscle tissue, e.g., by intramuscular injection, as well as for the in vitro transduction of muscle cells which can subsequently be introduced into a subject for treatment. The invention provides for sustained, high-level expression of a delivered nucleotide sequence encoding erythropoietin, and for in vivo secretion thereof from transduced muscle cells such that systemic delivery is achieved. | 04-29-2010 |
Patent application number | Description | Published |
20120210321 | Dormant Background Applications on Mobile Devices - The subject disclosure is directed towards a technology in which a mobile device maintains an application in a dormant state in which the application's process is not terminated and remains in memory, but the application cannot execute code. Further, state and execution context are maintained for the application, allowing the application to be quickly and efficiently resumed into the running state. To prevent the application from executing code while dormant, thread activity is suspended, requests canceled, completed or paused, resources detached, and so forth. Resource usage may be monitored for dormant applications, to remove a misbehaving dormant application process from memory if improperly using resources. | 08-16-2012 |
20120210326 | Constrained Execution of Background Application Code on Mobile Devices - The subject disclosure is directed towards a technology by which background application code (e.g., provided by third-party developers) runs on a mobile device in a way that is constrained with respect to resource usage. A resource manager processes a resource reservation request for background code, to determine whether the requested resources meet constraint criteria for that type of background code. If the criteria are met and the resources are available, the resources are reserved, whereby the background code is ensured priority access to its reserved resources. As a result, a properly coded background application that executes within its constraints will not experience glitches or other problems (e.g., unexpected termination) and thereby provide a good user experience. | 08-16-2012 |
Patent application number | Description | Published |
20140244053 | Apparatus and Method for Connecting Electrical Units - An apparatus and method for connecting electrical units including determining that a first electrical connection is mated with a first electrical receptacle at a first point of connection; determining that a second electrical connection is mated with a second electrical receptacle at a second point of connection, wherein the first second point of connection and the second point of connection are at opposite ends of an electrical cable; initiating delivery of voltage through the electrical cable; monitoring the voltage level of a source that outputs the delivery of the voltage; and comparing the voltage level of the source with a predetermined value to generate a comparison value. | 08-28-2014 |
20140266067 | Electrical Extension - An apparatus and method for configuring an electrical extension device, including measuring an electric current level being drawn from at least one of a plurality of electrical plugs by at least one of a plurality of loads; comparing the electric current level with a threshold to derive a comparison; and determining whether or not to charge the at least one of the plurality of loads based on the comparison. Additionally, the apparatus and method is for charging each of the at least one of the plurality of loads, wherein the charging is associated with a time duration, determining a charging state of one of the at least one of the plurality of loads and/or terminating the charge to the one of the at least one of the plurality of loads if the charging state indicates that it is at a fully charged capacity. | 09-18-2014 |
20140266070 | Apparatus and Method for Enhancing Battery Life - An apparatus and method for enhancing battery life including monitoring a first voltage level of a battery; receiving a first indication of the first voltage level; comparing the first indication to a first threshold to derive a comparison; determining if the battery needs charging based on the comparison; and configuring at least one switching mechanism to engage at least one capacitor to charge the battery. | 09-18-2014 |
20140283533 | Apparatus and Method for Electrical Transport Refrigeration in a Tractor-Trailer System - An apparatus and method for electrical transport refrigeration, including generating a direct current (DC) voltage; storing the DC voltage in a high voltage DC storage; sensing a current requirement from an electrical load (e.g., a refrigeration unit), wherein the current requirement is proportional to a power requirement of the electrical load; transporting the DC voltage from the high voltage DC storage to an inverter, wherein the DC voltage is in an amount consistent with the power requirement; converting the DC voltage to an inverted AC voltage: determining a voltage in a voltage path; and triggering a switch to connect the electrical load to the voltage path it the voltage is the inverted AC voltage. And, the apparatus and method may include connecting a battery to an operating control unit of the refrigeration unit to enable a soft start of a compressor. In one example, the apparatus is a tractor-trailer system. | 09-25-2014 |
20150033775 | Apparatus and Method for Monitoring and Controlling Load Requirements - An apparatus and method for monitoring and controlling load requirements relating to a transport refrigeration unit, including receiving one or more power information from a load: a power consumption information or a power requirement information; receiving one or more state information from the load: state of a compressor, state of a condenser, state of a compressor fan, state of an evaporation fan or state of a condenser fan; determining the following based on one or more power information and one or more state information: a) an amount of power to supply, b) a time duration for supplying power, and c) an operational frequency. In one example, one or more auxiliary information are also used for the determination: a fluid leakage measurement, a current measurement, a timer measurement, a counter measurement, a controlled environment temperature, or an environmental temperature. | 02-05-2015 |