Clarke, IE
Aidan Clarke, Dublin IE
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20090013305 | GENERATING A SUBSET MODEL FROM A MODEL - A technique for identifying a minimum number of model elements associated with a model for generating a subset model of the model that includes receiving a model, a set of model elements and a set of dependency types associated with the model; assigning a collector component to each of the received model elements; locating a model element dependent on the received model element by one of the received dependency types; receiving from each collector a dependent model element, and for each dependent model element, determining whether the dependent model element has been collected by another collector with the same dependency type and updating a subset model list with the collected dependent model element to build a list of collected dependent model elements for generating a subset model in response to a negative determination. | 01-08-2009 |
Barry Clarke, Dublin IE
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20160061525 | MAGNETIC ANNEALING APPARATUS AND MAGNETIC ANNEALING METHOD - Disclosed is a magnetic annealing apparatus including a processing container that performs a magnetic annealing processing on a plurality of substrates accommodated therein in a magnetic field; a substrate holder that holds the plurality of substrates substantially horizontally in the processing container; a division heater including a plurality of sub-division heaters and covering a substantially entire circumferential surface of an outer periphery of a predetermined region of the processing container along a longitudinal direction; a magnet installed to cover an outside of the division heater; and a controller configured to feedback-control a temperature of a predetermined control target heater among the plurality of sub-division heaters, and to control temperatures of the plurality of sub-division heaters other than the predetermined control target heater based on a control output obtained by multiplying a control output of the predetermined control target heater and a predetermined ratio. | 03-03-2016 |
20160061526 | MAGNETIC ANNEALING APPARATUS - Disclosed is a magnetic annealing apparatus including a processing container having a horizontally-elongated tubular shape and configured to perform a magnetic annealing processing on a plurality of substrates accommodated therein in a magnetic field; a heating unit provided to cover at least a part of a surface of the processing container that extends in a longitudinal direction, from outside; a magnet provided to cover the heating unit from the outside of the heating unit; a substrate holder configured to hold the plurality of substrates within the processing container; and a heat shielding plate provided to surround a part of the substrate holder. | 03-03-2016 |
Colin Clarke, Dublin IE
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20110317158 | CYTOLOGICAL METHOD FOR ANALYZING A BIOLOGICAL SAMPLE BY RAMAN SPECTROSCOPY - Provided herein are systems and methods that permit low resolution Raman spectroscopy to be used for detection of biological components within cells in order to classify the cells, for example, as premalignant, malignant, or benign. | 12-29-2011 |
Colin Clarke, Waterford IE
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20120214710 | METHOD OF PREDICTING RESPONSE TO THALIDOMIDE IN MULTIPLE MYELOMA PATIENTS - A method of predicting response to thalidomide, or thalidomide analogs, in an individual with cancer, especially cancers for which thalidomide has been implicated as a treatment, such as Multiple Myeloma (MM) employs one or more of a panel of biomarkers that have been shown to be differentially expressed in cancer patients that respond to thalidomide (hereafter “Responders”) relative to cancer patients that do not respond to thalidomide (hereafter “Non-responders). The method involves assaying a biological sample from the individual to determine the abundance of at least three biomarkers including Vitamin-D binding protein precursor (VDB) (Sequence ID 1) and Serum amyloid A protein (SAA) (Sequence ID 3), and at least one of beta-2-microglobulin (B2M) (Sequence ID 4), Haptoglobin (Hp) precursor (fragment) (Sequence ID 5), and zinc-alpha-2-glycoprotein (ZAG) (Sequence ID 2). Correlation of the abundance value for the at least three biomarkers with a reference abundance value from a Responder or Non-responder enables predication of response to thalidomide for the patient. | 08-23-2012 |
Conor Clarke, County Dublin IE
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20120330839 | TRANSACTION PROCESSING - A transaction processing system for the real time authorization of payment transactions, The system comprises a verification system ( | 12-27-2012 |
20140201079 | TRANSACTION PROCESSING - A transaction processing system for the real time authorization of payment transactions. The system comprises a verification system ( | 07-17-2014 |
Conor Clarke, Dublin IE
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20100017328 | Transaction processing - A transaction processing system for the real time authorization of payment transactions, The system comprises a verification system ( | 01-21-2010 |
Daniel Clarke, Curracloe IE
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20120243750 | METHOD, APPARATUS AND SYSTEM FOR OUTPUTTING A GROUP OF IMAGES - There is described an apparatus for outputting a group of images for display, the group being taken from a plurality of images, each image in the plurality of images having a face located therein, the apparatus comprising a processor configured to: retrieve a set of images from a storage medium, the set of images containing at least the plurality of images from which the group of images to be displayed is selected; identify the face in each of the plurality of images; identify variable features on the face in each of the plurality of images; establish the group of images in accordance with a measure of the dissimilarity between the variable features in the plurality of images; and output the group of images for display. | 09-27-2012 |
20120251082 | METHOD, APPARATUS AND SYSTEM FOR GENERATING MEDIA CONTENT - A method of generating media content is described which comprises capturing still or moving image content items at a capture device and uploading the captured image content items and image content metadata indicating a time of capture of each of the image content items to a network. A playback log indicating playback times of audio content items listened to by the user of the capture device is stored. One or more of the captured image content items is correlated with one or more portions of the playback log based on the time of capture indicated by the metadata relating to the one or more captured content items and the playback times indicated by the playback log. A media output is generated as a collection of a plurality of the captured image content items stored at the network accompanied by audio content related to the portion of the playback log which is correlated with the captured image content items in the collection. In this way, a media output can be generated at a network, such as a cloud network, from user generated image content and commercial audio content which the user who captured the image content was listening to at the time the image content was captured. | 10-04-2012 |
David Clarke, Ballybrit IE
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20120305441 | Delivery Catheter System with Micro and Macro Movement Control - A tray and packaging system for a prosthetic valve delivery system permits conversion from a storage and/or shipping configuration to a set up and preparation configuration. In a first configuration, a delivery system can be supported by first and second main trays with the elongate catheter of the delivery system arranged to extend linearly from the first main tray to the second main tray, and in a second configuration, the delivery system can be supported by the first and second main trays with the elongate catheter of the delivery system turned back in a U-shaped manner with the deployment portion of the delivery system positioned to the side of the control handle portion of the delivery system. | 12-06-2012 |
20120310332 | Delivery Catheter System With Micro and Macro Movement Control - A prosthetic valve delivery system that is improved in controllability by way of a proximal handle system. Such a handle system of the present invention advantageously permits a controlled fine or micro movement or adjustment of a distal sheath for uncovering a plunger that is to be loaded with a prosthetic valve for deployment thereof. The delivery system of the present invention permits a trigger-release for a gross or macro movement to the sheath relative to the plunger. Also, the control handle of the delivery system is shaped and contoured for ease in manipulation of the micro-control actuator. | 12-06-2012 |
David Clarke, Patrickswell IE
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20120133025 | APPARATUS FOR ELECTROSTATIC DISCHARGE PROTECTION - An apparatus includes an electrostatic discharge (ESD) protection device configured to protect a circuit from ESD conditions. The protection device includes an emitter region having a first diffusion polarity; a collector region laterally spaced apart from the emitter region, and having the first diffusion polarity; and a barrier region interposed laterally between the emitter region and the collector region while contacting the emitter region. The barrier region has a second diffusion polarity opposite from the first diffusion polarity. The device can further include a base region having the second diffusion polarity, and laterally surrounding and underlying the emitter region and the barrier region. The barrier region can have a higher dopant concentration than the base region, and block a lateral current flow between the collector and emitter regions, thus forming a vertical ESD device having enhanced ESD performance. | 05-31-2012 |
David Clarke, Galway IE
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20150251798 | Package for a Medical Device - A package includes a box having an interior volume and a first pocket disposed at a first corner of the box. The first pocket includes a lip configured for a finger of a user to be inserted therein for removal of the package from a storage unit. | 09-10-2015 |
David J. Clarke, Patrickswell IE
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20130208385 | PROTECTION SYSTEMS FOR INTEGRATED CIRCUITS AND METHODS OF FORMING THE SAME - Harsh electrical environments integrated circuit protection for system-level robustness and methods of forming the same are provided. In one embodiment, a protection system includes dual-polarity high blocking voltage primary and secondary protection devices each electrically connected to a pad. The primary protection device has a current handling capability greater than a current handling capability of the secondary protection devices, and the secondary protection device has a turn-on speed that is faster than a turn-on speed of the primary protection device so as to decrease pad voltage overshoot when a fast transient electrical event occurs on the pad. Additionally, the holding voltage of the primary protection device is less than a holding voltage of the secondary protection device such that once the primary protection device has been activated the primary protection device clamps the pad voltage so as to minimize a flow of high current through the secondary protection device. | 08-15-2013 |
20140043715 | APPARATUS AND METHODS FOR AMPLIFIER FAULT PROTECTION - An amplifier includes a fault protection control circuit biased from the signal pin and a fault protection circuit including a first PMOS transistor and a second PMOS transistor. The sources and bodies of the first and second PMOS transistors can be connected to one another, the drain of the first PMOS transistor can be connected to the amplifier's output, and the drain of the second PMOS transistor can be connected to a signal pin. During normal operating conditions, the fault protection control circuit can turn on the first and second PMOS transistors. However, the fault protection control circuit can turn off the first PMOS transistor and turn on the second PMOS transistor when an overvoltage condition is detected, and can turn on the first PMOS transistor and turn off the second PMOS transistor when an undervoltage condition is detected, even when the integrated circuit is unpowered. | 02-13-2014 |
20140138735 | JUNCTION-ISOLATED BLOCKING VOLTAGE DEVICES WITH INTEGRATED PROTECTION STRUCTURES AND METHODS OF FORMING THE SAME - Junction-isolated blocking voltage devices and methods of forming the same are provided. In certain implementations, a blocking voltage device includes an anode terminal electrically connected to a first p-well, a cathode terminal electrically connected to a first n-well, a ground terminal electrically connected to a second p-well, and an n-type isolation layer for isolating the first p-well from a p-type substrate. The first p-well and the first n-well operate as a blocking diode. The blocking voltage device further includes a PNPN silicon controlled rectifier (SCR) associated with a P+ region formed in the first n-well, the first n-well, the first p-well, and an N+ region formed in the first p-well. Additionally, the blocking voltage device further includes an NPNPN bidirectional SCR associated with an N+ region formed in the first p-well, the first p-well, the n-type isolation layer, the second p-well, and an N+ region formed in the second p-well. | 05-22-2014 |
20140332843 | JUNCTION-ISOLATED BLOCKING VOLTAGE STRUCTURES WITH INTEGRATED PROTECTION STRUCTURES - Junction-isolated blocking voltage devices and methods of forming the same are provided. In certain implementations, a blocking voltage device includes an anode terminal electrically connected to a first p-well, a cathode terminal electrically connected to a first n-well, a ground terminal electrically connected to a second p-well, and an n-type isolation layer for isolating the first p-well from a p-type substrate. The first p-well and the first n-well operate as a blocking diode. The blocking voltage device further includes a PNPN silicon controlled rectifier (SCR) associated with a P+ region formed in the first n-well, the first n-well, the first p-well, and an N+ region formed in the first p-well. Additionally, the blocking voltage device further includes an NPNPN bidirectional SCR associated with an N+ region formed in the first p-well, the first p-well, the n-type isolation layer, the second p-well, and an N+ region formed in the second p-well. | 11-13-2014 |
20140339601 | DUAL-TUB JUNCTION-ISOLATED VOLTAGE CLAMP DEVICES FOR PROTECTING LOW VOLTAGE CIRCUITRY CONNECTED BETWEEN HIGH VOLTAGE INTERFACE PINS AND METHODS OF FORMING THE SAME - Dual-tub junction-isolated voltage clamp devices and methods of forming the same are provided herein. The voltage clamp device can provide junction-isolated protection to low voltage circuitry connected between first and second high voltage interface pins. In certain implementations, a voltage clamp device includes a PNPN protection structure disposed in a p-well, a PN diode protection structure disposed in an n-well positioned adjacent the p-well, a p-type tub surrounding the p-well and the n-well, and an n-type tub surrounding the p-type tub. The p-type tub and the n-type tub provide junction isolation, the p-type tub can be electrically floating, and the n-type tub can be electrically connected to the second pin. The first and second pins can operate at a voltage difference below the junction isolation breakdown, and the second pin can operate with higher voltage than the first pin. | 11-20-2014 |
20160094026 | OVERVOLTAGE PROTECTION DEVICE AND METHOD - A protection device is provided that exhibits a turn on time of order of one nanosecond or less. Such a device provides enhanced protection for integrated circuits against electrostatic discharge events. This in turn reduces the risk of device failure in use. The protection device can include a bipolar transistor structure connected between a node to be protected and a discharge path. | 03-31-2016 |
David J. Clarke, Limerick IE
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20110101444 | ELECTROSTATIC PROTECTION DEVICE - An apparatus including an electrostatic discharge (ESD) protection device comprising a semiconductor having first, second and third regions arranged to form a transistor, wherein the first region is doped with a first impurity of a first conductivity type and is separated from the second region which is doped with a second impurity of a second conductivity type opposite the first type, and wherein a dimensional constraint of the regions defines an operational threshold of the ESD protection device. In one example, the separation between a collector and an emitter of a bipolar transistor defines a trigger voltage to cause the electrostatic discharge protection device to become conducting. In another example, a width of a bipolar transistor base controls a holding voltage of the electrostatic discharge protection device. | 05-05-2011 |
Devon Clarke, Dublin IE
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20130007140 | SELECTIVE DELIVERY OF CONTENT VIA ELECTRONIC MAIL - A method that includes identifying a first electronic mail (email) addressed to at least two groups of recipients, the first email comprising content. The method further can include communicating the first email comprising the content to a first group of recipients. The method also can include generating a second email different than the first email and not comprising the content, the second email comprising information that indicates a contact that the second group of recipients are to contact regarding subject matter associated with the first email, and communicating the second email to a second group of recipients. | 01-03-2013 |
20130007154 | SELECTIVE DELIVERY OF CONTENT VIA ELECTRONIC MAIL - A method that includes identifying a first electronic mail (email) addressed to at least two groups of recipients, the first email comprising content. The method further can include communicating the first email comprising the content to a first group of recipients. The method also can include generating a second email different than the first email and not comprising the content, the second email comprising information that indicates a contact that the second group of recipients are to contact regarding subject matter associated with the first email, and communicating the second email to a second group of recipients. | 01-03-2013 |
Elaine Clarke, Dublin IE
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20130238408 | SYSTEMS AND METHODS FOR ATTACHING LOYALTY PROGRAM DATA TO AN ELECTRONIC PAYMENT SCHEME - Methods and apparatus are disclosed for attaching loyalty program data to an electronic payment in a payment processing network. In an embodiment, a method transmits, from a merchant to a bank network (BankNet), an authorization request comprising a primary account number (PAN) of a customer and routes the request to a payment card issuer. The method then identifies a loyalty program associated with the PAN and receives, at the BankNet, an authorization response comprising an indicator of the loyalty program. The method forwards the authorization response to an acquirer and sends the authorization response to the merchant. In another embodiment, a system transmits an authorization request and routes the authorization request to a BankNet in response to determining that a merchant is a member of a loyalty program. The system receives an authorization response comprising an indicator of the loyalty program, forwards the response to an acquirer and the merchant. | 09-12-2013 |
Eoin F. Clarke, Westmeath IE
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20080255391 | Chiral Phosphorus Compounds - A process for the stereoselective preparation of a P-chiral four-co-ordinated phosphorus compound, the process comprising reacting a first reactant selected from the group consisting of a chiral alcohol, chiral amine or chiral thiol, with a second reactant comprising a P-chiral three-co-ordinated phosphorus compound, in the presence of an electrophile. | 10-16-2008 |
Frank Clarke, Galway IE
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20100264050 | Packaging for a Stent Delivery System - The present invention relates to a method of packaging and a packaging system for treated stents which minimise the level of exposure of the stents to oxygen, moisture and light. The package comprises two compartments, the compartments being in communication with each other via a breathable membrane. | 10-21-2010 |
Gareth Clarke, Limerick IE
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20150119936 | PERCUTANEOUS TETHER LOCKING - A tether-securing device is provided that includes a tubular element, which is shaped so as define a lateral wall that surrounds a lumen. The lateral wall is shaped so as to define a one-way locking opening. The tether-securing device further includes at least one tether, which (a) has at least a first tether end portion, and (b) passes through the lumen and the one-way locking opening. The tether-securing device additionally includes first and second tissue anchors. The first tissue anchor is connected to the first tether end portion. The one-way locking opening is configured to (a) allow sliding of the at least one tether in a first direction through the one-way locking opening, and (b) inhibit sliding of the at least one tether in a second direction opposite the first direction. Other embodiments are also described. | 04-30-2015 |
Gerry Clarke, Moycullen IE
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20080234800 | Stent Including a Toggle Lock - A stent includes cylindrical rings disposed adjacent to each other. Each cylindrical ring includes longitudinal segments that may be disposed generally parallel to a longitudinal axis of the stent. The longitudinal segments are coupled to each other by toggle lock struts. The toggle lock struts are disposed substantially at the center of the circumferentially adjacent longitudinal segments. When the stent is in a compressed state for delivery, the toggle lock struts are bent such that the longitudinal segments are disposed close to each other. Upon expansion of the stent, the toggle lock struts straighten such that the longitudinal segments are disposed father apart form each other. | 09-25-2008 |
20100268320 | Endovascular Implant Having an Integral Graft Component and Method of Manufacture - A covered stent including an endovascular implant having a polymeric stent structure with an integrally formed membrane-like graft component, also referred to as a stent-graft, and methods of manufacturing the one-piece stent-graft by an injection molding process. A molding system for creating the polymeric stent structure is injected with a melt stream of moldable material that is forced between a parting line of the molding system to create a thin, flexible membrane-like structure within the open areas or interstitial spaces of the molded stent structure. The stent-graft so created is a one-piece, unified structure molded from a polymeric material in a single manufacturing step. | 10-21-2010 |
20130013054 | Endovascular Implant Having an Integral Graft Component and Method of Manufacture - A covered stent including an endovascular implant having a polymeric stent structure with an integrally formed membrane-like graft component, also referred to as a stent-graft, and methods of manufacturing the one-piece stent-graft by an injection molding process. A molding system for creating the polymeric stent structure is injected with a melt stream of moldable material that is forced between a parting line of the molding system to create a thin, flexible membrane-like structure within the open areas or interstitial spaces of the molded stent structure. The stent-graft so created is a one-piece, unified structure molded from a polymeric material in a single manufacturing step. | 01-10-2013 |
Gerry Clarke, Co. Galway IE
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20110071616 | Stent Including a Toggle Lock Strut - A tubular stent includes cylindrical rings disposed adjacent to each other and coupled to each other by a plurality of longitudinal segments. Each cylindrical ring includes circumferentially oriented toggle lock struts. The toggle lock struts include a first arm and a second arm coupled together at an elbow. When the stent is in a compressed configuration for delivery, the toggle lock struts are bent at the elbow such that the first arm is disposed at an angle of less than 180 degrees relative to the second arm. Upon radial expansion of the stent, the toggle lock struts are unbent to a straight configuration and permitted to relax slightly beyond the straight configuration to a locked configuration such that the angle between the first arm and the second arm changes from less than 180 degrees to more than 180 degrees. | 03-24-2011 |
20120010691 | Particle Embedded Polymer Stent and Method of Manufacture - A particle embedded polymer stent and method of manufacture, which includes a stent delivery system having a catheter; a balloon operably attached to the catheter; and a polymer stent disposed on the balloon, the stent comprising struts interconnected to form a tubular body. Each of the struts includes in cross section a drug-free core region; and a drug region surrounding and immediately adjacent to the core region, the drug region including drug particles. The drug-free core region and the drug region are made of a single polymer, the single polymer having a drug-safe softening temperature. | 01-12-2012 |
Gerry Clarke, Gortachalla IE
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20080234831 | Bioresorbable Stent and Method of Making - A method of making a polymeric stent includes providing a molding apparatus including a central core pin and a plurality of slides, wherein each of the slides includes grooves on an inner surface the slide, wherein the grooves are formed in the shape of the stent. A molten polymer is injected into the grooves and allowed to solidify. The slides are moves away from the central core pin and the solidified polymer, in the shape of a stent, is removed. The central core also may or may not include corresponding grooves depending on the desired cross section of struts and crowns of the stent. | 09-25-2008 |
Greg Clarke, Blessington IE
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20110290418 | HYDROGEN PEROXIDE COMPLEXES AND THEIR USE IN THE CURE SYSTEM OF ANAEROBIC ADHESIVES - Provided is a complex of hydrogen peroxide and at least one compound represented by Formula I: | 12-01-2011 |
James Clarke, Banbridge IE
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20100042739 | CONFIRMATION OF DELIVERY OF CONTENT TO AN HTTP/TCP DEVICE - A method to confirm delivery of data to a receiving device via a sending socket is disclosed. One embodiment of the method comprises determining when a predetermined amount of data has been removed from a send buffer of the sending socket and sending a confirmation when the predetermined amount of data has been removed from the send buffer. Other embodiments are described and claimed. | 02-18-2010 |
John Clarke, Galway IE
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20090081271 | MEDICAL DEVICES HAVING A FILTER INSERT FOR CONTROLLED DIFFUSION - An implantable or insertable medical device is provided which includes as components: (a) a substrate component comprising a depression that is at least partially filled with a therapeutic agent-containing material that comprises a first therapeutic agent, and (b) a pre-formed filter insert disposed in the depression such that it regulates transport of chemical species between the depression and the exterior of the device upon implantation or insertion of the device in vivo. | 03-26-2009 |
20090081272 | MEDICAL DEVICES HAVING A METAL PARTICULATE COMPOSITION FOR CONTROLLED DIFFUSION - An implantable or insertable medical device is provided which includes as components: (a) a substrate component comprising a depression that is at least partially filled with a therapeutic agent-containing material that comprises a first therapeutic agent, and (b) a particulate composition disposed in the depression such that it regulates transport of chemical species between the depression and the exterior of the device upon implantation or insertion of the device into a subject. | 03-26-2009 |
20090123521 | Medical devices having coatings for controlled therapeutic agent delivery - According to an aspect of the invention, medical devices are provided, which include a nanoparticle-derived inorganic layer disposed over a least a portion of structure that includes a substrate, and optionally, a therapeutic-agent-containing layer disposed over at least a portion of the substrate. In some embodiments, the inorganic layer is a nanoporous inorganic layer. Other aspects of the invention comprise methods for forming such medical device. | 05-14-2009 |
20110008260 | Use of Nanocrystals for Drug Delivery from a Balloon - A drug delivery balloon ( | 01-13-2011 |
20110130829 | Medical Devices Containing Therapeutic Agents - The present invention pertains to implantable or insertable medical devices which comprise a substrate and one or more therapeutic-agent-containing regions contain one or more therapeutic agents. In various aspects of the invention, one or more characteristics of such therapeutic-agent-containing regions are controlled. Further aspects of the invention relate to methods of forming such devices and to methods of using such devices. | 06-02-2011 |
John Clarke, Claregalway IE
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20120095396 | Drug Eluting Medical Device Utilizing Bioadhesives - A medical balloon having an inner surface and an outer surface comprising a first coating composition comprising at least one therapeutic agent, the first coating composition disposed on the balloon outer surface and forming an interface between the balloon outer surface and the first coating composition and a second coating composition comprising a bioadhesive, the second coating composition disposed on the first coating composition so as to not affect the interface between the balloon outer surface and the first coating composition, the bioadhesive selected so as to adhere to body tissue, and methods of making the same. | 04-19-2012 |
20130066257 | Design of Interventional Cutting Balloon with Enhanced API Delivery Capability - A medical balloon assembly including an inflatable balloon and at least one cutting element extending from the balloon is disclosed. The inflatable balloon includes an outer wall facing outward and an inner wall facing outward. The cutting element comprises a plurality of openings therein including a first opening and a second opening. The first opening is closed off by a portion of the outer wall. The cutting element further includes a passageway extending from the first opening to the second opening. The passageway is defined by the cutting element and the portion of the outer wall which closes off the passageway. The passageway may contain a therapeutic agent. | 03-14-2013 |
John Clarke, Tipperary IE
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20110020404 | DIAGNOSTIC METHOD AND KIT - The invention relates to methods for diagnosis of tuberculosis in an animal, the methods comprising determining the presence or absence of, or an immune response to a group of antigens comprising (i) the group consisting of Rv3616 antigen, MPB70 antigen, MPB83 antigen, and ESAT 6 antigen; or (ii) at least seven of the antigens of the group consisting of Rv3616 antigen, MPB70 antigen, MPB83 antigen, ESAT 6 antigen, CFP10 antigen, α crystalline 2 antigen, PE35 antigen, and PPE68 antigen. Also provided is a method for the diagnosis of the presence of tuberculosis in a reservoir animal e.g. a badger, said method comprising determining the presence or absence of, or an immune response to Rv3616 antigen, MPB70 antigen, and MPB83 antigen. Kits for carrying out the methods are also provided. | 01-27-2011 |
John T. Clarke, Co. Galway IE
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20110160659 | Drug-Delivery Balloons - Drug-delivery balloons, as well as related medical devices and methods, are disclosed. | 06-30-2011 |
John T. Clarke, Galway IE
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20100008970 | Drug-Eluting Endoprosthesis - A drug-eluting endoprosthesis that includes a bioerodible metal portion and a therapeutic agent. In some aspects, the endoprosthesis includes a plurality of discrete deposits and a plurality of overlying layers each overlying one of the plurality of discrete deposits. Each discrete deposit includes one or more therapeutic agents and each overlying layer includes one or more bioerodible metals. In other aspects, the bioerodible metal portion includes at least two bioerodible metal regions having different electronegativities. The at least two bioerodible metal regions being in electrical contact with each other. The bioerodible metal erodes in a physiological environment to release the therapeutic agent. | 01-14-2010 |
John T. Clarke, Kiniska IE
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20090028785 | MEDICAL DEVICES WITH COATINGS FOR DELIVERY OF A THERAPEUTIC AGENT - Described herein are implantable coated medical devices, such as intravascular stents, for delivering therapeutic agents to the body tissue of a patient, and methods for making such medical devices. In particular, described herein are implantable coated medical devices comprising a substrate having a surface, and a coating disposed upon the surface that comprises a coating composition that includes a releasable metal oxide. The coating is free of polymer or a particular type of polymer that is not a part of any releasable metal oxide. | 01-29-2009 |
20090118821 | ENDOPROSTHESIS WITH POROUS RESERVOIR AND NON-POLYMER DIFFUSION LAYER - An endoprosthesis such as a coronary stent includes a porous reservoir of drug, e.g., a porous layer formed of a ceramic and an overlayer formed of ceramic or metal for controlling elution of drug from the reservoir. | 05-07-2009 |
John T. Clarke, Claregalway IE
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20090017188 | METHODS FOR MAKING DRUG-ELUTING MEDICAL DEVICES - The present invention is directed to medical implants that are configured to controllably release therapeutic agent to a target site of a patient and methods of making these implants. Embodiments of the present invention may include a method comprising the steps of providing a tube having a wall with inner and outer surfaces and defining a passageway, forming an opening through the wall of the tube, applying a porous coating layer to at least one of the inner and outer surfaces of the tube, and loading a therapeutic agent solution into the passageway so that therapeutic agent passes through the opening and into the porous coating layer. The method may also include removing portions of the tube to form the implantable medical device, which may be a stent. | 01-15-2009 |
20110251590 | BALLOON CATHETERS WITH FIBERS FOR DELIVERY OF THERAPEUTIC AGENT AND METHODS OF MAKING THE SAME - A medical device comprises a catheter with an expandable member, fibers extending from the outer surface of the expandable member, and therapeutic agent coated on the fibers or carried in the spaces between the fibers. Upon expansion of the expandable member, the therapeutic agent is delivered from the medical device. A surfactant may be coated on the fibers. A method of manufacturing comprises coating the outer surface of an expandable member with a metallic layer, coating the metallic layer with at least one polymeric layer, forming a plurality of holes in at least one polymeric layer, forming fibers in the holes, and removing at least one polymeric layer. | 10-13-2011 |
Leo Clarke, County Clare IE
Paul Clarke, Dublin IE
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20140106371 | Peptide Analogues of PA-IL and Their Utility for Glycan and Glycoconjugate Analysis and Purification - Provided are peptide analogues of PA-IL and compositions containing them. The PA-IL peptide analogues have altered carbohydrate binding specificity relative to a PA-IL of SEQ ID NO:1, and thus the analogues contain amino acid substitutions in SEQ ID NO:1. The substitutions can be at positions 50, 52 and 53 of SEQ ID NO:1 and can include combinations of amino acid substitutions at those positions | 04-17-2014 |
20150253336 | Peptide Analogues of PA-IL and Their Utility for Glycan and Glycoconjugate Analysis and Purification - Provided are peptide analogues of PA-IL and compositions containing them. The PA-IL peptide analogues have altered carbohydrate binding specificity relative to a PA-IL of SEQ ID NO:1, and thus the analogues contain amino acid substitutions in SEQ ID NO:1. The substitutions can be at positions 50, 52 and 53 of SEQ ID NO:1 and can include combinations of amino acid substitutions at those positions. Also included are methods for detecting changes in the glycosylation of carbohydrates and for separating biomolecules which contain glycoproteins or glycoconjugates. | 09-10-2015 |
Sean Clarke, Ardee IE
Patent application number | Description | Published |
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20130127153 | INTERNAL CONNECTOR TUBE FOR USE WITH CONNECTING SLEEVE TO PROVIDE AIRTIGHT CONNECTION BETWEEN HOLLOW TUBES - A connecting structure connects a hollow first tube and a hollow second tube. The second tube comprises internal screw threads. The connecting structure further includes a hollow connecting sleeve connecting the first tube to the second tube. Portions of the first tube and the second tube are positioned within the connecting sleeve. The first tube is movable within the connecting sleeve in a direction parallel to an internal surface of the first tube. The connecting structure further includes a hollow connecting tube connected to an internal surface of the second tube and positioned within the first tube. The connecting tube comprises a first end having external screw threads engaged with the internal screw threads of the second tube. At least one O-ring is located on an external portion of a second end of the connecting tube, opposite the first end. | 05-23-2013 |