Patent application number | Description | Published |
20090081083 | Anti-clogging device and method for in-gel digestion applications - An integrated proteomics sample preparation device and method for in-gel digestion of proteins and for desalting and concentrating samples prior to further analysis such as by MALDI TOF and/or electro-spray ionization (ESI) mass spectrometry. The device and method of the present invention allow for digestion, desalting and concentration of sample prior to analysis. More specifically, the device in accordance with an embodiment of the present invention includes a plurality of wells in fluid communication with a an outlet or drainage opening containing a three dimensional structure comprising a plurality of sorptive particles entrapped in a porous polymer matrix so as to form a device capable of carrying out solid phase extraction. In a preferred embodiment, the wells are configured so as to prevent a sample carrier present in the wells from clogging the outlet when subjected to a driving force such as vacuum. The device also reduces or eliminates overflowing of a well in the event a drain becomes clogged during automated operation. | 03-26-2009 |
20100009460 | Multifunctional vacuum manifold - A laboratory device design particularly for a multiplate format that includes a manifold wherein the position of the plate is not a function of gasket compression or vacuum rate applied. In one embodiment, the device has a modular design, wherein one or more removable inserts, preferably with different functionalities can be positioned between a base component and a collar component. The particular insert(s) chosen depend on the desired sample preparation or assay to be carried out. The insert(s) are stacked and are positioned between the base and collar as a unit, so that the stack within the manifold does not move during evacuation of the vacuum chamber. The consistent position of the insert(s) facilitates using vacuum sample processing with automated liquid handlers. | 01-14-2010 |
20100129900 | Layered Flask Cell Culture System - A multilayered cell culture apparatus for the culturing of cells is disclosed. The cell culture apparatus is defined as an integral structure having a plurality of flexible cell culture compartments in combination with a spacer material maintaining air space(s). The expandable compartments of the cell culture apparatus have imparted therein gas permeable membranes in combination with air spaces that will allow the free flow of gases between the cell culture compartments and the external environment. Furthermore an interconnecting passageway is provided between each compartment and between the cell culturing vessel and the external environment. The expandable vessel promotes the growth of large numbers of adherent or suspension cells by providing the volumes of nutrient medium and gaseous exchange. | 05-27-2010 |
20100151511 | Biological culture assembly - The invention relates to a resealable or a single use cell culture assembly for use in growing, storing and transporting, cell and tissue cultures. The assembly includes a support frame for receiving a base member insert having an upper surface, such as a microscope slide, and a well frame, preferably partitioned into a plurality of well compartments having sidewalls with upper and lower surfaces, upper and lower edges, and upper and lower well openings. The well frame is adapted to be operatively positioned on the upper surface of the base member, and includes a sealing means positioned on or within the lower edge of the well frame. The sealing means is adapted to operatively create a liquid-impermeable releasable seal or barrier when the lower surface of the well frame is positioned on the upper surface of the base member, such that the sealing means is releasably positioned on the upper surface of the base member for maintaining a liquid-impermeable barrier between well compartments. The assembly may include a cover or lid positioned over the upper opening of the well frame. When the assembly is in a closed position, the well frame can be secured to the support frame by a variety of closure means. | 06-17-2010 |
20100307967 | FILTRATION DEVICE - The present invention provides a vacuum filter device ( | 12-09-2010 |
20110038757 | IMMUNOASSAY PRODUCT AND PROCESS - The invention is directed to an apparatus useful in conducting detection of compounds on blotting membranes. The device is comprised of several layers including a porous support layer below the blotting membrane(s), a flow distributor above the blotting membrane(s) and optionally a well on the flow distributor to contain the liquid to the desired area and to allow for lower starting volumes of such liquid. Preferably, the flow distributor is a non-binding or low binding hydrophilic porous membrane such as a 0.22 micron membrane and the support layer is a grid or sintered porous material. The distributor and support are held together to form an envelope around the membrane(s). The use of a hinge, clips, and other such devices is preferred in doing so. | 02-17-2011 |
20110256025 | IMMUNOASSAY PRODUCT AND PROCESS - The invention is directed to an apparatus useful in conducting detection of compounds on blotting membranes. The device is comprised of several layers including a porous support layer below the blotting membrane(s), a flow distributor above the blotting membrane(s) and optionally a well on the flow distributor to contain the liquid to the desired area and to allow for lower starting volumes of such liquid. Preferably, the flow distributor is a non-binding or low binding hydrophilic porous membrane such as a 0.22 micron membrane and the support layer is a grid or sintered porous material. The distributor and support are held together to form an envelope around the membrane(s). The use of a hinge, clips and other such devices is preferred in doing so. | 10-20-2011 |
20120315189 | Immunoassay Product And Process - The embodiments disclosed herein are directed to an apparatus useful in conducting detection of compounds on blotting membranes. The device is comprised of several layers including a porous support layer below the blotting membrane(s), a flow distributor above the blotting membrane(s) and optionally a well on the flow distributor to contain the liquid to the desired area and to allow for lower starting volumes of such liquid. Preferably, the flow distributor is a non-binding or low binding hydrophilic porous membrane such as a 0.22 micron membrane and the support layer is a grid or sintered porous material. The distributor and support are held together to form an envelope around the membrane(s). The use of a hinge, clips and other such devices is preferred in doing so. | 12-13-2012 |
20130017620 | All-In-One Sample Preparation Device And Method - Sample preparation device that allows for a complete bind, wash, elute, buffer-exchange and concentration process to be carried out without sample transfer between multiple devices. The device includes a reservoir, a column for holding chromatography media, a holder region for holding a filtration device, and an outlet. The filtration device plugs into the holder region of the centrifugal device, and the assembly can be placed in an optional holder. The assembly, with or without the optional holder, can be placed in a conventional centrifuge tube for centrifugation. The entire bind, wash, elute, buffer exchange and concentration steps can be carried out with the apparatus without any pipette transfers (and the associated sample losses. The sample preparation device also can be used for binding and washing steps, in which case the filtration device is not needed, and for buffer exchange and concentration steps, in which case the media is not needed. | 01-17-2013 |
20130038727 | Cell Image Capturing and Remote Monitoring Systems - The present invention provides a cell culture data and cell image capturing and remote monitoring system that includes an imaging sensor pod having one or more cameras to capture multiple color still and/or motion images of cell cultures and cells located on a support and/or in a liquid located in a culture vessel within an incubator. The images can be taken at varying magnifications, and from different discrete locations on the support or in the vessel round the clock. The captured data and images are wirelessly transmitted to a management control unit, and/or another wirelessly connected and remotely located data transmission device such as PDA, for a researcher to review and analyze to determine the health and viability of cells, and the status of the cell culture. The image capturing and remote monitoring system taught herein alleviates the need for a researcher to be in the physical presence of a biological sample in order to visually ascertain and analyze the health and viability of the sample and status of the cell culture. | 02-14-2013 |
20130062523 | DEVICES AND METHODS FOR INFRARED (IR) BASED QUANTITATION OF BIOMOLECULES - The present invention provides methods for quantitating one or more biomolecules in a sample using IR based techniques, sample holder devices for use in such methods as well as methods for manufacturing such sample holder devices. | 03-14-2013 |
20140017151 | All-In-One Sample Preparation Device And Method - Sample preparation device that allows for a complete bind, wash, elute, buffer-exchange and concentration process to be carried out without sample transfer between multiple devices. The device includes a reservoir, a column for holding chromatography media, a holder region for holding a filtration device, and an outlet. The filtration device plugs into the holder region of the centrifugal device, and the assembly can be placed in an optional holder. The assembly, with or without the optional holder, can be placed in a conventional centrifuge tube for centrifugation. The entire bind, wash, elute, buffer exchange and concentration steps can be carried out with the apparatus without any pipette transfers (and the associated sample losses. The sample preparation device also can be used for binding and washing steps, in which case the filtration device is not needed, and for buffer exchange and concentration steps, in which case the media is not needed. | 01-16-2014 |
20150108058 | FILTRATION DEVICE - A vacuum filter device comprising a filter body having two holders on opposite sides of a filter. Each holder contains a closed container in a fluid-tight, sealed relationship. The filter is retained by a compression sealing element and the sealing element is maintained in place by a compression element formed of a ring. The compression element is bonded to a portion of the body to hold it, the sealing element and filter in place under a compression seal. Optionally a port in the compression element is formed to align with the vent of the device. Further, an alignment feature on the compression element ensures the port is in alignment with the vent of the device. The device also includes a vacuum port communicating with the downstream side of the filter, and hence the filtrate container. | 04-23-2015 |
20160103045 | All-In-One Sample Preparation Device And Method - Sample preparation device that allows for a complete bind, wash, elute, buffer-exchange and concentration process to be carried out without sample transfer between multiple devices. The device includes a reservoir, a column for holding chromatography media, a holder region for holding a filtration device, and an outlet. The filtration device plugs into the holder region of the centrifugal device, and the assembly can be placed in an optional holder. The assembly, with or without the optional holder, can be placed in a conventional centrifuge tube for centrifugation. The entire bind, wash, elute, buffer exchange and concentration steps can be carried out with the apparatus without any pipette transfers (and the associated sample losses. The sample preparation device also can be used for binding and washing steps, in which case the filtration device is not needed, and for buffer exchange and concentration steps, in which case the media is not needed. | 04-14-2016 |
20160137961 | Layered Flask Cell Culture System - The present invention is a cell cultivating vessel or device, such as a single or multitier flask, including a cover having a top plate, a side wall and a resealable port; an intermediate tray for receiving cells and cell culture media, having a bottom plate, a side wall, and a gap region formed between an interior upwardly angled lip located on an interior portion of the intermediate tray bottom plate and an adjacent outwardly angled side wall portion of the intermediate tray bottom plate, wherein the lip has a outwardly swooping curvilinear edge feature; and a base tray for receiving the cells and cell culture media, including a bottom plate and a side wall. The intermediate tray is positioned between the cover and the base tray, such that the gap region of the intermediate tray bottom plate is in alignment with the port located on the cover, resulting in the port, the intermediate tray and the base tray in fluid communication with one another which provides direct access, such as by a user to remove and/or add cells, cell media, and nutrients located on each of the intermediate and/or the base trays. Alternatively, the cell cultivating flask includes a plurality of intermediate trays stacked on top of one another and the gap regions of each intermediate tray are in alignment with each other and with the port on the cover. | 05-19-2016 |