Willingham
Aarron Willingham, Mountain View, CA US
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20130171242 | Single-Stranded RNAi Agents Containing an Internal, Non-Nucleic Acid Spacer - Single-stranded RNA molecules comprise one or more internal, non-nucleotide spacers, covalently linked with nucleotide portions of the molecule are provided. The single-stranded RNA molecules function as guide or antisense strands that are capable of inhibiting gene expression via an RNA interference mechanism, and thus represent single-stranded RNAi agents. The single-stranded RNAi molecules can be used in methods for a variety of therapeutic, diagnostic, target validation, genomic discovery, genetic engineering, and pharmacogenomic applications. | 07-04-2013 |
Aarron Willingham, La Jolla, CA US
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20090075294 | Eukaryotic mechanosensory transduction channel - The present invention provides, for the first time, nucleic acids encoding a eukaryotic mechanosensory transduction channel (MSC) protein. The proteins encoded by these nucleic acids form channels that can directly detect mechanical stimuli and convert them into electrical signals. These nucleic acids and the proteins they encode can be used as probes for sensory cells in animals, and can be used to diagnose and treat any of a number of human conditions involving inherited, casual, or environmentally-induced loss of mechanosensory transduction activity. | 03-19-2009 |
Aarron T. Willingham, Mountain View, CA US
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20130217756 | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA) - The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity, and/or modulate a gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against target gene expression. | 08-22-2013 |
Aarron T. Willingham, San Francisco, CA US
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20150299696 | SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS - The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity, and/or modulate a gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against target gene expression. | 10-22-2015 |
Charles B. Willingham, Framingham, MA US
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20090155162 | TREATMENT METHOD FOR OPTICALLY TRANSMISSIVE BODIES - A method of treating zinc sulfide transmissive bodies includes using the same metal layer to treat multiple transmissive bodies, catalyzing the recrystallization of the bodies to remove defects from the bodies and forming multispectral zinc sulfide. The metal layer is brought into contact with one of the transmissive bodies. The transmissive body and the metal layer are then subjected to elevated temperature and pressure. The metal layer may include any of a variety of suitable metals, such as platinum, cobalt, silver, nickel, and/or copper. The metal layer may be a foil that is wrapped around the transmissive body. Alternatively the metal layer may be a rigid metal piece, for example being machined to fit the shape of the transmissive bodies. The reuse of the metal layer to treat multiple transmissive bodies reduces the cost of treating the transmissive bodies. | 06-18-2009 |
David John Willingham, Essex GB
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20080297063 | Power gating of circuits - A control device for controlling power supplied to circuitry is disclosed. The circuitry comprises a plurality of portions, each of said plurality of circuit portions being arranged between a first voltage level source and a second voltage level source, said first and second voltage level sources being adapted to output different voltage levels; said control device being adapted to control power supplied to each of said plurality of circuit portions. The control device comprises: a plurality of power switching devices corresponding to said plurality of circuit portions, each power switching device being arranged between said first voltage level source and a corresponding circuit portion such that when one of said plurality of power switching devices is switched on a voltage level close to a voltage level output by said first voltage level source is supplied to said corresponding circuit portion and said corresponding circuit portion is powered up and when switched off said corresponding circuit portion is isolated from said first voltage level source and said corresponding circuit portion is powered down, said control device further comprising: at least one voltage equalisation switching device arranged between two power switching devices to provide a low resistance path between said two power switching devices when they are both turned on and to isolate said two power switching devices from each other when either are turned off. | 12-04-2008 |
David John Willingham, Ilford GB
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20090129194 | Access collision within a multiport memory - A multiport memory | 05-21-2009 |
Field F. Willingham, Decatur, GA US
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20100191052 | BARREL SYSTEM FOR USE WITH AN ENDOSCOPE - The present embodiments provide apparatus and methods for facilitating cauterization of tissue. In one embodiment, the apparatus comprises a proximal barrel and a distal barrel, which are coupled together and moveable with respect to one another. At least a portion of the proximal barrel may be coupled to an endoscope to secure the apparatus to the endoscope. At least one electrocautery member is disposed within a lumen of the distal barrel and configured to cauterize at least a segment of tissue pulled into a lumen of the proximal barrel and/or the lumen of the distal barrel. | 07-29-2010 |
Gavin Willingham, Hampshire GB
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20090172636 | INTERACTIVE DEVELOPMENT TOOL AND DEBUGGER FOR WEB SERVICES - A development environment, comprising: text editing means ( | 07-02-2009 |
20090320045 | SERVER COMPUTER COMPONENT - An interface for interfacing between a receiving component of a server application and a remote application, the receiving component being operable to receive serialised objects from the remote application via the interface, the interface comprising: means for ascertaining if a piece of code associated with the received object is locally stored and directly available to the server application; and means for locally storing the associated piece of code in the event that it is not already locally stored and directly available to the server application. | 12-24-2009 |
Gavin Willingham, Southampton GB
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20090276660 | SERVER COMPUTER COMPONENT - Processing means for assisting computer programs running in a distributed computer system, the processing means including: detection means ( | 11-05-2009 |
20090300093 | SERVER COMPUTER - A server computer system comprising: means for permitting a first and a second version of a component or application to run on the server computer system simultaneously; means for identifying one of the versions as currently applicable and the other as not currently applicable; and means for connecting a requesting client to the currently applicable version in response to a request by the client to access the component or application. | 12-03-2009 |
Gavin Peter Willingham, Hampshire GB
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20120284346 | Requesting Computer Data Assets - A computer management apparatus, method and computer program operable for displaying a data file on a client computer, wherein the data file comprises a structure file and a first plurality of data elements, the apparatus comprising: a send component operable for sending a first message comprising a request for the structure file; a receive component operable for receiving the structure file; an evaluate component operable for determining a second plurality of data elements, wherein the second plurality of data elements is associated with a visible area; a send component further operable for sending a second message, wherein the second message comprises a request for the second plurality of data elements; a receive component further operable for receiving the second plurality of data elements; and a display component, responsive to receipt of the second plurality of data elements, operable for displaying the second plurality of data elements in the visible area. | 11-08-2012 |
Jeremy Willingham, Annapolis, MD US
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20140287383 | Scoring Server - A scoring server for assessing technical skills in a practical environment. A client application acts as a middle man between a terminal and an operating system to capture and forward all input from and output to students to the scoring server. The scoring server compares recorded student activity against a list of tasks deemed capable of accomplishing course objectives assigned to students. As objectives are met by a student, the students' grade is updated in real-time. Each student passes or fails an exam based on tasks performed and skills employed. The client application exists for two operating system types: windows and LINUX. A LINUX client employs a pseudoterminal to permit access to terminal input/output and communication through stdin, stdout, and stderr channels. A windows client (WC) comprises a WC command line activity logger and a WC monitor process to intercept all communication through stdin, stdout, and stderr communication channels. | 09-25-2014 |
John Herman Willingham, Memphis, TN US
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20130229014 | POWER GENERATING FLOATING VESSEL - The present invention pertains to hydroelectric generation devices, and more particularly pertains to a fixed or floating paddlewheel electric generation device that may be placed in any flowing liquid source in order to generate power. Such an overall power generating system includes a paddlewheel component that is situated within an artificial channel properly configured to increase the velocity of the flowing liquid therethrough, thereby providing a manner of generating paddlewheel rotation at a speed greater than that relative to the main body of the fluid itself. Such an efficient process thus allows for effective conversion of such hydrokinetic power into mechanical energy in order to couple to a device to produce electricity from such captured power. The resultant electrical energy can then be supplied to a user's individual location or into an electrical grid in order to supply a clean, efficient, power source. | 09-05-2013 |
20150008675 | POWER GENERATING FLOATING VESSEL - Hydroelectric generation devices, and more particularly fixed or floating paddlewheel electric generation devices that may be placed in any flowing liquid source in order to generate power, are presented. Such an overall power generating system includes a paddlewheel component that is situated within an artificial channel properly configured to increase the velocity of the flowing liquid therethrough, thereby providing a manner of generating paddlewheel rotation at a speed greater than that relative to the main body of the fluid itself. The inventive system thus permits power generation through the capture of the kinetic energy derived from the paddlewheel rotation at a level that is acceptable in relation to available hydrokinetic energy of the fluid source. | 01-08-2015 |
Joseph C. Willingham, Elkin, NC US
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20080219778 | SINGLE MOTOR BLOWER - An apparatus for installation of a material having discrete elements. The apparatus includes a supply material having discrete elements and a transporter system downstream of the supply material having discrete elements. In the preferred embodiment, the transporter system includes: (i) a high speed, inline blower (ii) a material agitator upstream of the inline blower and (iii) a planetary transmission connected to the shaft of the blower for providing a lower speed mechanical output to the material agitator. The material agitator may include a plurality of concentric rings with serrations on the upper surface of each ring. In the preferred embodiment, the apparatus further includes an applicator assembly connected downstream to the transporter system. | 09-11-2008 |
Karen Willingham, Greensboro, NC US
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20150227326 | SYSTEM AND METHOD FOR AUTOMATED DIGITAL RFID PRINTING AND INTEGRATION - A system for automated RFID printing and integration is disclosed. The system includes an automated digital RFID printer utilized in combination with server system from a client/server system. The system also includes a corresponding method for automated RFID printing and integration as well as a non-transitory computer storage media having instructions stored thereon which, when executed, execute a method for automated RFID printing and integration. | 08-13-2015 |
Keisha Renee Willingham, Rural Hall, NC US
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20080245377 | CIGARETTE COMPRISING DARK-CURED TOBACCO - A cigarette is provided that includes a rod of smokable material circumscribed by an outer wrapping material and a filter element, which may include an adsorbent material such as activated carbon, attached to one end of the rod of smokable material. The smokable material includes at least about 5 percent by weight of a dark air-cured tobacco, based on the dry weight of the smokable material, blended with additional tobacco materials such as flue-cured tobacco, burley tobacco, Oriental tobacco, Maryland tobacco, and mixtures thereof. | 10-09-2008 |
Mark C. Willingham, Summerville, SC US
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20120276013 | GENETICALLY DETERMINED MOUSE MODEL OF RESISTANCE TO TRANSPLANTABLE CANCERS - We have established and studied a colony of mice with a unique trait of host resistance to both ascites and solid cancers induced by transplantable cells. One dramatic manifestation of this trait is age-dependent spontaneous regression of advanced cancers. This powerful resistance segregates as a single-locus dominant trait, is independent of tumor burden and is effective against cell lines from multiple types of cancer. During spontaneous regression or immediately following exposure, cancer cells provoke a massive infiltration of host leukocytes which form aggregates and rosettes with tumor cells. The cytolytic destruction of cancer cells by innate leukocytes is rapid and specific without apparent damage to normal cells. The mice are healthy, cancer-free and have a normal life span. These observations suggest a previously unrecognized mechanism of immune surveillance that may have potential for therapy or prevention of cancer. | 11-01-2012 |
Mark C. Willingham, Winston-Salem, NC US
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20120107293 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER - A method of treating cancer comprises: (a) providing allogenic or autologous white blood cells from a suitable donor; and then (b) administering the white blood cells to the subject in an amount effective to treat the cancer. Preferably the white blood cells comprise innate immune cells. Preferably the white blood cells comprise less than 10% by number of cytotoxic T lymphocytes. Preferably the white blood cells, or more particularly the innate immune cells, are preselected in vitro to kill cancer cells in vitro (for example, by collecting white blood cells from the patient and determining that the white blood cells kill cancer cells in vitro before and thereby pre-selecting the donor, before collecting a subsequent population of cells from the donor for administration). | 05-03-2012 |
Thomas C. Willingham, Weddington, NC US
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20130247763 | SULFUR SEAL DEVICE - Embodiments of the invention are directed to a sulfur trap comprising an inlet, a first chamber, a divider, a second chamber, an outlet, and a float assembly. The float assembly may have many different configurations, but generally comprises a float and plug, is configured to float within liquid sulfur, and is operatively coupled to a seal seat in the divider for sealing and unsealing the first chamber from the second chamber. Generally, only liquid sulfur is allowed to pass from the first chamber into the second chamber. However, the sulfur trap may be configured to allow for pressure relief, such that during an overpressure event the plug and seal seat disengage and allow the liquid-gas mixture to flow into the second chamber to prevent damage within the system. In some embodiments a filter and/or the flow of liquid sulfur is directed to collect debris from the liquid sulfur. | 09-26-2013 |
Tylon O. Willingham, Winchester, CA US
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20110213883 | SYSTEM AND METHOD FOR OBJECT MIGRATION USING WAVES - A system and method for information technology (IT) migration includes determining a relationship among objects to be migrated such that the relationship includes a set of objects having at least one of a common feature or dependency between the objects in the set. The objects are grouped into a plurality of migration waves such that cross-wave relationships are minimized among the plurality of migration waves. The objects are migrated wave by wave. | 09-01-2011 |
Wendell D. Willingham, Perrysburg, OH US
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20080210657 | Closure and package for high-temperature applications - A plastic closure includes a plastic closure shell having a base wall with a central opening and a skirt for securing the closure to a container neck finish. A plastic disk includes angularly spaced fingers extending into the central opening of the shell base wall and external beads on the fingers for engaging an inner periphery of the central opening to retain the disk within the shell. The beads have flat undersurfaces and the inner periphery of the central opening has a ledge with a conical surface engaged by the beads. Any doming that occurs in the disk and/or the closure shell base wall increases the surface contact between the finger beads and the opposing surface of the ledge so that removal of the shell from a container neck finish will simultaneously lift and remove the disk from the neck finish without having the beads snap through the central opening in the shell so that the shell is removed while the disk is retained on the neck finish. | 09-04-2008 |
20090196948 | Apparatus for placing mold charges into a compression molding machine - An apparatus for placing a mold charge into a mold of a compression molding machine includes a carrier mounted for rotation around a first axis, at least one arm mounted on the carrier for rotation around a second axis at an angle to the first axis, and a mold charge pick-up cup on the arm for receiving a mold charge, transporting the mold charge and placing the mold charge into a mold of the compression molding machine. A cam is carried in stationary position adjacent to the carrier surrounding the first axis, and a cam follower is operatively coupled to the arm in engagement with the cam for rotating the arm and the mold charge pick-up cup around the second axis as the carrier is rotated around the first axis. The second axis of rotation of the arm preferably is perpendicular to the first axis of rotation of the carrier, and the cam and follower preferably are such that the mold charge pick-up cup is oriented horizontally to receive a mold charge and oriented vertically to deposit the mold charge in the mold of the compression molding machine. A control valve preferably is carried for selective application of vacuum and air under pressure through a passage in the arm to the mold charge pick-up cup to assist in pick-up, transport and deposit of the mold charge into the mold. | 08-06-2009 |
William Preston Willingham, Park City, UT US
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20110277246 | METHOD AND APPARATUS FOR DYNAMICALLY CORRECTING POSTURE - An orthopedic device for improving posture while sitting, having a foundation member including a front portion for upper legs and a bowl portion for lower pelvic area. The bowl portion has a central portion and an upwardly inclined lateral portion. The lateral portion and the front portion collectively surround the central portion. The central portion has regions of varying flexibility and the lateral portion has regions of varying flexibility. The bowl portion applies an upwardly and inwardly compressive force when the lower pelvic area is disposed in the bowl portion, and rotates on a supporting surface between a first position when the lower pelvic area is not disposed in the bowl portion, and a second position, rotationally forward of the first position, when the lower pelvic area is disposed in the bowl portion, to thereby cause a forward rotational tilting of the lower pelvic area into a forward lordotic position after the lower pelvic area is placed in the bowl portion. | 11-17-2011 |
20120299350 | APPARATUS AND SYSTEM FOR DYNAMICALLY CORRECTING POSTURE - An orthopedic device for improving posture while sitting, having a foundation member including a front portion for upper legs and a bowl portion for lower pelvic area. The bowl portion has a central portion and an upwardly inclined lateral portion. The lateral portion and the front portion collectively surround the central portion. A platform portion is connected with a concave recessed portion. An arm portion is connected to the platform portion. The central portion has plural regions of varying flexibility and the lateral portion has plural regions of varying flexibility. A seating apparatus is connected with the orthopedic seating device. | 11-29-2012 |
20130291306 | CUSHION DEVICE - A cushion device including a first material layer is attached with a first plurality of viscoelastic members. A second material layer is attached with a second plurality of viscoelastic members. A material wall surrounds the first material layer and the second material layer. A first fill material is disposed between the first material layer and the second material layer. | 11-07-2013 |
20150015042 | APPARATUS AND SYSTEM FOR DYNAMICALLY CORRECTING POSTURE - An orthopedic device for improving posture while sitting, having a foundation member including a front portion for upper legs and a bowl portion for lower pelvic area. The bowl portion has a central portion and an upwardly inclined lateral portion. The lateral portion and the front portion collectively surround the central portion. A channel attachment is connected with one or more pelvic crest portions. The channel attachment portion connects over a concave recessed portion. The central portion has plural regions of varying flexibility and the lateral portion has plural regions of varying flexibility. | 01-15-2015 |