Patent application number | Description | Published |
20130275174 | MOBILE AND/OR CLOUD BASED TOOL FOR ENABLING ACCURATE INFORMATION OF NEW AND RETROFIT PROJECTS - A real-time, mobile, energy savings and cost estimation tool may be provided. The energy savings and cost estimation tool may be implemented on a mobile electronic device, such as, but not limited to a laptop computer, tablet, or a smart phone, for example. A user may create a project and define project information using the energy savings and cost estimation tool while at the project site. For example, the user may discuss the project with a potential customer, ask questions about the project to be created or retrofitted, walk around the project site, and enter the project information into the energy savings and cost estimation tool. Using the project information gathered, the energy savings and cost estimation tool may provide real-time feedback, such as an energy usage audit, an energy usage solution design, an energy analysis, and/or a return on investment (ROI) analysis for the project, to the user. | 10-17-2013 |
Patent application number | Description | Published |
20120238574 | (1, 1, 1,3,3,3 -HEXAFLUORO-2 HYDROXYPROPAN- 2 -YL) PHENYL DERIVATIVE, PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR USE FOR THE TREATMENT OF ATHEROSCLEROSIS - The present invention relates to (1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl derivatives having the general formula (I) to pharmaceutical compositions comprising the same and to the use of these (1,1,1,3,3,3-hexafluoro-2-hydroxy-propan-2-yl)phenyl derivatives in the treatment of atherosclerosis. | 09-20-2012 |
20120283239 | 1H-[1,2,3]TRIAZOLO[4,5-c]PYRIDINE-4-CARBONITRILE DERIVATIVES - The invention relates to 1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile derived Cathepsin S inhibitors of Formula (I), wherein R | 11-08-2012 |
Patent application number | Description | Published |
20090074723 | Method of Treating or Retarding the Development of Blindness - A method for treating an ocular disorder characterized by the defect or absence of a normal gene in the ocular cells of a human or animal subject involves administering to the subject by subretinal injection an effective amount of a recombinant adeno-associated virus carrying a nucleic acid sequence encoding the normal gene under the control of a promoter sequence which expresses the product of the gene in the ocular cells. The ocular cells are preferably retinal pigment epithelial (RPE) cells, and the gene is preferably an RPE-specific gene, e.g., RPE65. The promoter is one that can express the gene product in the RPE cells. Compositions for subretinal administration are useful in this method. | 03-19-2009 |
20100272688 | METHOD OF TREATING OR RETARDING THE DEVELOPMENT OF BLINDNESS - A method for treating an ocular disorder characterized by the defect or absence of a normal gene in the ocular cells of a human or animal subject involves administering to the subject by subretinal injection an effective amount of a recombinant adeno-associated virus carrying a nucleic acid sequence encoding the normal gene under the control of a promoter sequence which expresses the product of the gene in the ocular cells. The ocular cells are preferably retinal pigment epithelial (RPE) cells, and the gene is preferably an RPE-specific gene, e.g., RPE65. The promoter is one that can express the gene product in the RPE cells. Compositions for subretinal administration are useful in this method. | 10-28-2010 |
20100297084 | METHOD FOR TRANSDUCING CELLS WITH PRIMARY CILIA - This invention provides methods for transducing a ciliated cell with a recombinant serotype 2 adeno-associated virus (AAV) vector. Additionally, the invention provides methods of treating diseases associated with a mutated gene by transducing a ciliated cell with a recombinant serotype 2 AAV vector containing a corrective transgene. | 11-25-2010 |
20120225930 | METHOD OF TREATING OR RETARDING THE DEVELOPMENT OF BLINDNESS - A method for treating an ocular disorder characterized by the defect or absence of a normal gene in the ocular cells of a human or animal subject involves administering to the subject by subretinal injection an effective amount of a recombinant adeno-associated virus carrying a nucleic acid sequence encoding the normal gene under the control of a promoter sequence which expresses the product of the gene in the ocular cells. The ocular cells are preferably retinal pigment epithelial (RPE) cells, and the gene is preferably an RPE-specific gene, e.g., RPE65. The promoter is one that can express the gene product in the RPE cells. Compositions for subretinal administration are useful in this method. | 09-06-2012 |
20120244127 | AAV Vectors Expressing SEC10 for Treating Kidney Damage - A method for enhancing repair of damaged mammalian tubular epithelial cells involves delivering to the tubular epithelial cells of a subject in need thereof a composition comprising an adeno-associated virus (AAV) comprising an AAV capsid having an amino acid sequence of a selected AAV serotype, and a minigene having AAV inverted terminal repeats and a Sec10 gene operatively linked to regulatory sequences that direct expression of Sec10 in the epithelial cells. In one embodiment, delivery is accomplished by retrograde intrauretal injection. In an embodiment the AAV vector includes a capsid of AAV serotype 2/8. Therapeutic compositions containing such AAV are provided. | 09-27-2012 |
20130216500 | METHOD OF TREATING OR RETARDING THE DEVELOPMENT OF BLINDNESS - A method for treating an ocular disorder characterized by the defect or absence of a normal gene in the ocular cells of a human or animal subject involves administering to the subject by subretinal injection an effective amount of a recombinant adeno-associated virus carrying a nucleic acid sequence encoding the normal gene under the control of a promoter sequence which expresses the product of the gene in the ocular cells. The ocular cells are preferably retinal pigment epithelial (RPE) cells, and the gene is preferably an RPE-specific gene, e.g., RPE65. The promoter is one that can express the gene product in the RPE cells. Compositions for subretinal administration are useful in this method. | 08-22-2013 |
20140087444 | Proviral Plasmids and Production of Recombinant Adeno-Associated Virus - Proviral plasmids contain a modular gene expression cassette with one or a combination of (i) a wildtype 5′ AAV2 ITR sequence flanked by unique restriction sites that permit ready removal or replacement of said ITR; (ii) a promoter flanked by unique restriction sites that permit ready removal or replacement of the entire promoter sequence; (iii) a polylinker sequence that permits insertion of a gene coding sequence without modification thereof, wherein the gene is operatively linked to, and under the regulatory control of, the aforementioned promoter; (iv) a bovine growth hormone polyadenylation sequence flanked by unique restriction sites that permit ready removal or replacement of said polyA sequence; and (v) a wildtype 3′ AAV2 ITR sequence flanked by unique restriction sites that permit ready removal or replacement of the 3′ ITR. These plasmids enable rapid manipulation of the components of the cassette, e.g., rapid mutation and/or replacement of any component, and thereby increase the efficiency of recombinant viral vector, e.g., rAAV, production. | 03-27-2014 |
20140377224 | Method of Treating or Retarding the Development of Blindness - A method for treating an ocular disorder characterized by the defect or absence of a normal gene in the ocular cells of a human or animal subject involves administering to the subject by subretinal injection an effective amount of a recombinant adeno-associated virus carrying a nucleic acid sequence encoding the normal gene under the control of a promoter sequence which expresses the product of the gene in the ocular cells. The ocular cells are preferably retinal pigment epithelial (RPE) cells, and the gene is preferably an RPE-specific gene, e.g., RPE65. The promoter is one that can express the gene product in the RPE cells. Compositions for subretinal administration are useful in this method. | 12-25-2014 |
Patent application number | Description | Published |
20100292799 | Method for Inserting and Positioning an Artificial Disc - A method for inserting an intervertebral artificial disc is provided with the intervertebral disc including a first endplate having a plurality of protrusions for attaching to an adjacent vertebrae and an extension portion extending towards a second adjacent vertebrae. A second endplate is provided with a plurality of protrusions for attaching to a second adjacent vertebrae and an extension portion extending towards the first adjacent vertebrae. A flexible member having an upper portion and a lower portion and a slider plate positioned within the upper portion of the flexible member is also provided. The extension portion of the first endplate is adapted to fit within a first cavity in the upper portion of the flexible member and the extension portion of the second endplate is adapted to fit within a second cavity in the lower portion of the flexible member. | 11-18-2010 |
20100292801 | Artificial Disc - An intervertebral artificial disc is provided with a first endplate having a plurality of protrusions for attaching to an adjacent vertebrae and an extension portion extending towards a second adjacent vertebrae. A second endplate is provided with a plurality of protrusions for attaching to a second adjacent vertebrae and an extension portion extending towards the first adjacent vertebrae. A flexible member having an upper portion and a lower portion and a slider plate positioned within the upper portion of the flexible member is also provided. The extension portion of the first endplate is adapted to fit within a first cavity in the upper portion of the flexible member and the extension portion of the second endplate is adapted to fit within a second cavity in the lower portion of the flexible member. | 11-18-2010 |
20110137421 | Transforaminal Prosthetic Spinal Disc Apparatus - An intervertebral prosthetic implant having a first endplate having a first surface configured to substantially engage with a first vertebral body and a second surface having an extension with a concave contact surface, the concave contact surface being spaced apart from the second surface. A second endplate is provided with a first surface configured to substantially engage with a second vertebral body and a second surface comprising a convex contact surface, and the second endplate having a securing element positioned along and above the second surface defining a first and second window on opposing sides of the second surface. The securing element extends along the width and length of the lower endplate and configured with an access hole. An extension portion extends from the first surface of the first endplate through the access hole of the securing element and contacts the second surface of the second endplate. | 06-09-2011 |
20110230967 | Intervertebral Nucleus and Annulus Implants and Method of Use Thereof - The invention encompasses devices and methods for treating one or more damaged, diseased, or traumatized intervertebral discs to reduce or eliminate associated back pain. Specifically, the invention encompasses intervertebral nucleus and annulus implants that are resistant to migration in and/or expulsion from an intervertebral disc space. The invention further encompasses kits including the implantable devices of the invention and associated delivery tools to treat annular and nuclear tissue. | 09-22-2011 |
20110264152 | Insertion Tool Assembly - Insertion tool assemblies for positioning an implant at a target location in a patient. Insertion tool assemblies that comprise first and second jaw portions configured to engage an implant; a sleeve assembly coupled to the first and second jaw portions; and a handle coupled to the sleeve assembly. | 10-27-2011 |
20110295370 | Spinal Implants and Methods of Use Thereof - The invention encompasses devices and methods for treating one or more damaged, diseased, or traumatized intervertebral discs to reduce or eliminate associated back pain. Specifically, the invention encompasses interspinous spacers, for example, corpectomy spacers that are suitable for insertion into an intervertebral disc space. | 12-01-2011 |
20120150298 | Spine Stabilization Device and Methods - An implant stabilizes two adjacent bones of a joint, while enabling a natural kinematic relative movement of the bones. Support components are connected to each bone of the joint, and a flexible core is interposed between them. The core and at least one of the support components are provided with a smooth sliding surface upon which the core and support component may slide relative to each other, enabling a corresponding movement of the bones. The surfaces may have a mating curvature, to mimic a natural movement of the joint. The core is resilient, and may bend or compress, enabling the bones to move towards each other, and or to bend relative to each other. | 06-14-2012 |
20120215314 | Six Degree Spine Stabilization Devices and Methods - An implant stabilizes two adjacent bones of a joint, while enabling a natural kinematic relative movement of the bones. Support components are connected to each bone of the joint, and a flexible core is interposed between them. The core and at least one of the support components are provided with a smooth sliding surface upon which the core and support component may slide relative to each other, enabling a corresponding movement of the bones. The surfaces may have a mating curvature, to mimic a natural movement of the joint. The core is resilient, and may bend or compress, enabling the bones to move towards each other, and or to bend relative to each other. | 08-23-2012 |
20120290093 | Transforaminal Prosthetic Spinal Disc Apparatus - An intervertebral prosthetic implant having a first endplate having a first surface configured to substantially engage with a first vertebral body and a second surface having an extension with a concave contact surface, the concave contact surface being spaced apart from the second surface. A second endplate is provided with a first surface configured to substantially engage with a second vertebral body and a second surface comprising a convex contact surface, and the second endplate having a securing element positioned along and above the second surface defining a first and second window on opposing sides of the second surface. The securing element extends along the width and length of the lower endplate and configured with an access hole. An extension portion extends from the first surface of the first endplate through the access hole of the securing element and contacts the second surface of the second endplate. | 11-15-2012 |
20130110240 | Artificial Discs | 05-02-2013 |
20140052257 | Spine Stabilization Device and Methods - An implant stabilizes two adjacent bones of a joint, while enabling a natural kinematic relative movement of the bones. Support components are connected to each bone of the joint, and a flexible core is interposed between them. The core and at least one of the support components are provided with a smooth sliding surface upon which the core and support component may slide relative to each other, enabling a corresponding movement of the bones. The surfaces may have a mating curvature, to mimic a natural movement of the joint. The core is resilient, and may bend or compress, enabling the bones to move towards each other, and or to bend relative to each other. | 02-20-2014 |
20140142703 | Artificial Disc - An intervertebral artificial disc is provided with a first endplate having a plurality of protrusions for attaching to an adjacent vertebrae and an extension portion extending towards a second adjacent vertebrae. A second endplate is provided with a plurality of protrusions for attaching to a second adjacent vertebrae and an extension portion extending towards the first adjacent vertebrae. A flexible member having an upper portion and a lower portion and a slider plate positioned within the upper portion of the flexible member is also provided. The extension portion of the first endplate is adapted to fit within a first cavity in the upper portion of the flexible member and the extension portion of the second endplate is adapted to fit within a second cavity in the lower portion of the flexible member. | 05-22-2014 |
20140277497 | Interbody Standalone Intervertebral Implant - Stand-alone interbody fusion devices and corpectomy devices suitable for use with an oblique implantation. The stand-alone interbody fusion devices may include a spacer having a substantially U-shaped body and a plate coupled to the spacer. The overall shape of the implant is asymmetrical such that a median plane, an oblique plane, or both planes divide the spacer and the plate into two asymmetrical halves. The implants are shaped and configured to allow for an oblique or anterolateral approach to the spine or an oblique corpectomy. | 09-18-2014 |
Patent application number | Description | Published |
20080294425 | Method and apparatus for performing semantic update and replace operations - A method of changing semantic information comprises changing a first bi-directional coupling between a surface region in a document and a first semantic object to a second bi-directional coupling between the surface region and a second semantic object. More particularly, the method may be comprised of identifying an occurrence of a surface region in a document, the surface region having a first link for coupling the surface region to a first semantic object, and the first semantic object having a first association for coupling the first semantic object with the surface region. The first link is replaced with a second link for coupling the surface region to a second semantic object. The first association is changed to a second association for coupling the second semantic object with the surface region. Another method for changing semantic information comprising selecting a semantic object stored in a data repository and changing the selected semantic object. A scope is then selected, either manually or automatically. A set of semantically anchored expressions associated with the semantic object is identified in response to the scope. A determination is made if the semantically anchored expressions are consistent with the changed semantic object and, if not, the semantically anchored expressions are updated so as to be consistent with the changed semantic object. | 11-27-2008 |
20080294426 | Method and apparatus for anchoring expressions based on an ontological model of semantic information - A method and apparatus for the recording and maintenance of semantic elements in electronically-held information objects provide for grounding semantic objects in an ontology, such that inheritance and other relations between concepts are preserved in persistent storage. The disclosed method and apparatus provide semantic document authors with a means to anchor concept references to specific, persistent, semantic objects, thereby providing the system with access to all properties of the underlying data model of the semantic objects being referenced, while also specifying the type and scope of their relations, as well as behavioral aspects of the visual and editing environment. | 11-27-2008 |
20080294427 | Method and apparatus for performing a semantically informed merge operation - A method and apparatus for performing an informed semantic merge operation comprises selecting a source region in a document and a target region in the same or a different document. A bi-directionally coupled surface region is identified in the source region and a bi-directionally coupled surface region is identified in the target region. A first semantic object coupled to the surface region in the source region is identified and a second semantic object coupled to the surface region in the target region is identified. The subcomponents of the first semantic object are combined with the subcomponents of the second semantic object by merging. | 11-27-2008 |
20080295013 | Method and apparatus for performing semantically informed text operations - One example of a semantically informed text operation comprises selecting a source region of a document and determining if the source region has a surface region bi-directionally coupled to a semantic object. The coupled semantic object is identified as are the presentation(s) associated with the semantic object. A target region of the same or anther document is selected. Any of the presentations that cannot be expressed in the target region are eliminated to identify a set of remaining presentations. A set of semantic choices based on the remaining presentations is determined. One of the semantic choices is selected and executed in the target region. | 11-27-2008 |
20080312885 | Hybrid method for simulation optimization - A computer-implemented method of solving a system optimization problem having a plurality of parameters of unknown value is comprised of randomly generating sets of values for unknown parameters within an the optimization problem. A population of original candidate solutions is generated by applying an algorithm for deterministic optimization to each of the sets of values. The population of solutions is ranked. Additional candidate solutions are iteratively generated from at least certain of the solutions in the population. The validity of the additional candidate solutions is checked, and the valid additional candidate solutions are added to the population of solutions. The population of solutions is re-ranked and at least one solution from the population of solutions is output when a predetermined criterion is met whereby the values for the parameters in the output solution may be used for controlling a system. | 12-18-2008 |
Patent application number | Description | Published |
20120041403 | Integrated Contoured Negative Pressure Bandages - An integrated negative pressure bandage is constructed with a non-woven polyurethane matrix pad secured on the outside surface to a sheet of polyurethane film formed with an outer adhesive boundary to establish a seal against the skin of the patient around the wound site. The inner surface of the non-woven matrix pad is covered with a silver nitrate mesh to promote healing of the wound site when the bandage is placed on top of the wound. A drain tube is contained within the non-woven matrix pad for connection with a source of negative pressure to draw the fluids and exudates from the wound for removal to a canister that is located remotely from the bandage. Contoured versions of the integrated bandage are provided for use on portions of the human body that present difficult locations for applications of negative pressure therapy, including the toes, heel, limbs, and sacral region. | 02-16-2012 |
20130023719 | System for Monitoring the Use of Medical Devices - A system for monitoring the use of a home-based medical apparatus providing medical therapy to a patient incorporates communication technology to permit communication from the operated component of the medical apparatus to a central station through one or more of Bluetooth® telephone communications, Smart Phone communications, Internet communications through a network, or other known or forthcoming communication devices. The operated medical apparatus can report any operational function to the central station for monitoring by medical professionals or caregivers, including the timing of any operation of the apparatus, the duration of operation, the effectiveness of the therapy, and malfunctions in the operation of the apparatus. The monitoring system is particularly adapted for use with inflation garment therapy and negative pressure wound therapy systems. The medical apparatus can also be provided with an RFD tag so that the medical apparatus, and perhaps the patient using the medical apparatus, can be found. | 01-24-2013 |
20130204106 | Cloud-Based Monitoring of Medical Devices - A system for monitoring the use of a home-based medical apparatus providing medical therapy to a patient incorporates communication technology to permit communication from the operated component of the medical apparatus via a cellular network to a Cloud storage site. The operated medical apparatus can report any operational function to the Cloud storage site, which can be accessed by appropriate medical professionals or caregivers by contacting the Cloud storage site through a cellular network. If the medical apparatus is properly configured, the medical professional could change certain operational functions of the medical apparatus through the Cloud by communicating with the medical apparatus directly. Alternatively, a medical caregiver can visit the home-based patient to modify the operation of the medical apparatus. By limiting the number of visits needed to maintain proper operation of the medical apparatus, a medical caregiver can provide services to a larger number of patients. | 08-08-2013 |
20140018637 | Cloud-Based Monitoring of Medical Devices - A system includes a communications device integrally incorporated into a remotely deployed medical device to monitor the operative status and use of the device. A home-based medical device will communicate directly through an integrated communications device to provide informational data to a Cloud server or professional caregiver without requiring input or activity by the patient. A remotely deployed medical device, such as a defibrillator, will provide periodic reports regarding the operational status, including remaining battery life, of the deployed device, thus allowing a service technician to provide maintenance service only when service is needed. Although the informational data is preferably send to a Cloud computing and storage site, the communications device can be accessed remotely and directly queried to provide requested informational data thus providing real time access to the status and utilization of the medical device and allowing the professional caregiver access to change operational parameters for the medical device. | 01-16-2014 |
20140343520 | Integrated Negative Pressure Bandages - An integrated negative pressure bandage is constructed with a non-woven polyurethane matrix pad secured on the outside surface to a sheet of polyurethane film formed with an outer adhesive boundary to establish a seal against the skin of the patient around the wound site. The integrated negative pressure bandage is applied to a patient having said wound by removing said release member and attaching said adhesive layer exposed by the removal of said release member to said patient such that said adhesive layer is sealed to the patient around said wound with said non-woven polymer matrix pad being positioned over said wound, and attaching said connector port to said source of negative pressure. The non-woven pad does not stored fluids and exudate, but the source of negative pressure continuously removes the fluids and exudate to a remote location. | 11-20-2014 |
Patent application number | Description | Published |
20100113900 | Multispot Monitoring for Use in Optical Coherence Tomography - Optical coherence tomography (herein “OCT”) based analyte monitoring systems are disclosed. In one aspect, techniques are disclosed that can identify fluid flow in vivo (e.g., blood flow), which can act as a metric for gauging the extent of blood perfusion in tissue. For instance, if OCT is to be used to estimate the level of an analyte (e.g., glucose) in tissue, a measure of the extent of blood flow can potentially indicate the presence of an analyte correlating region, which would be suitable for analyte level estimation with OCT. Another aspect is related to systems and methods for scanning multiple regions. An optical beam is moved across the surface of the tissue in two distinct manners. The first can be a coarse scan, moving the beam to provide distinct scanning positions on the skin. The second can be a fine scan where the beam is applied for more detailed analysis. | 05-06-2010 |
20110319731 | METHODS FOR NONINVASIVELY MEASURING ANALYTE LEVELS IN A SUBJECT - A method for noninvasively measuring analytes such as blood glucose levels includes using a non-imaging OCT-based system to scan a two-dimensional area of biological tissue and gather data continuously during the scanning. Structures within the tissue where measured-analyte-induced changes to the OCT data dominate over changes induced by other analytes are identified by focusing on highly localized regions of the data curve produced from the OCT scan which correspond to discontinuities in the OCT data curve. The data from these localized regions then can be related to measured analyte levels. | 12-29-2011 |
20120277554 | APPARATUS AND METHOD FOR CREATING A STABLE OPTICAL INTERFACE - A system and a method for creating a stable and reproducible interface of an optical sensor system for measuring blood glucose levels in biological tissue include a dual wedge prism sensor attached to a disposable optic that comprises a focusing lens and an optical window. The disposable optic adheres to the skin to allow a patient to take multiple readings or scans at the same location. The disposable optic includes a Petzval surface placed flush against the skin to maintain the focal point of the optical beam on the surface of the skin. Additionally, the integrity of the sensor signal is maximized by varying the rotation rates of the dual wedge prisms over time in relation to the depth scan rate of the sensor. Optimally, a medium may be injected between the disposable and the skin to match the respective refractive indices and optimize the signal collection of the sensor. | 11-01-2012 |
20130060108 | METHOD FOR DATA REDUCTION AND CALIBRATION OF AN OCT-BASED PHYSIOLOGICAL MONITOR - The present invention relates to a method and system for estimating blood analyte levels using a noninvasive optical coherence tomography (OCT) based physiological monitor. An algorithm correlates OCT-based estimated blood analyte data with actual blood analyte data determined by other methods, such as invasively. OCT-based data is fit to the obtained blood analyte measurements to achieve the best correlation. Once the algorithm has generated sets of estimated blood analyte levels, it may refine the number of sets by applying one or more mathematical filters. The OCT-based physiological monitor can be calibrated using an Intensity Difference plot or the Pearson Product Moment Correlation method. | 03-07-2013 |