Patent application number | Description | Published |
20080213185 | Transport agents for crossing the blood-brain barrier and into brain cancer cells, and methods of use thereof - The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished by the use of protein transport peptides derived from Neisseria outer membrane proteins, such as Laz. The invention also provides synthetic transit peptides comprised of the pentapeptide AAEAP. The invention further discloses methods for treating cancer, and specifically brain cancer, as well as other brain-related conditions. Further, the invention provides methods of imaging and diagnosing cancer, particular brain cancer. | 09-04-2008 |
20090137468 | CYTOTOXIC FACTORS FOR MODULATING CELL DEATH - Cytotoxic factors having use in modulating cell death, and their use in methods of treating necrosis or apoptosis-related conditions are disclosed. The invention also relates to methods for identifying active agents useful in treating conditions related to cell death. The present inventors have found that different pathogens produce different cytotoxic factor(s) having anticancer activity. The substantially pure cytotoxic factors can be used in a method of treating an infectious disease or a cancer. | 05-28-2009 |
20100008919 | COMPOSITIONS AND METHODS TO CONTROL ANGIOGENESIS WITH CUPREDOXINS - The present invention relates to compositions comprising cupredoxins, and their use to inhibit angiogenesis in mammalian cells, tissues, and animals, and particularly the angiogenesis that accompanies tumor development and particularly in humans. Specifically, the present invention relates to compositions comprising the cupredoxin(s), and or peptides that are variants, derivatives or structural equivalents of cupredoxins, which retain the ability to inhibit angiogenesis in mammalian cells, tissues or animals. These compositions may be peptides or pharmaceutical compositions, among others. The compositions of the invention may be used to treat any pathological condition that has as a symptom or cause, inappropriate angiogenesis, and particularly inappropriate angiogenesis related to tumor development. | 01-14-2010 |
20110077387 | TRANSPORT AGENTS FOR CROSSING THE BLOOD-BRAIN BARRIER AND INTO BRAIN CANCER CELLS, AND METHODS OF USE THEREOF - The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished by the use of protein transport peptides derived from | 03-31-2011 |
20120196805 | COMPOSITIONS AND METHODS TO CONTROL ANGIOGENESIS WITH CUPREDOXINS - The present invention relates to compositions comprising cupredoxins, and their use to inhibit angiogenesis in mammalian cells, tissues, and animals, and particularly the angiogenesis that accompanies tumor development and particularly in humans. Specifically, the present invention relates to compositions comprising the cupredoxin(s), and or peptides that are variants, derivatives or structural equivalents of cupredoxins, which retain the ability to inhibit angiogenesis in mammalian cells, tissues or animals. These compositions may be peptides or pharmaceutical compositions, among others. The compositions of the invention may be used to treat any pathological condition that has as a symptom or cause, inappropriate angiogenesis, and particularly inappropriate angiogenesis related to tumor development. | 08-02-2012 |
20130004431 | TRANSPORT AGENTS FOR CROSSING THE BLOOD-BRAIN BARRIER AND INTO BRAIN CANCER CELLS AND METHODS OF USE THEREOF - The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished by the use of protein transport peptides derived from | 01-03-2013 |
20130210731 | COMPOSITIONS AND METHODS TO CONTROL ANGIOGENESIS WITH CUPREDOXINS - The present invention relates to compositions comprising cupredoxins, and their use to inhibit angiogenesis in mammalian cells, tissues, and animals, and particularly the angiogenesis that accompanies tumor development and particularly in humans. Specifically, the present invention relates to compositions comprising the cupredoxin(s), and or peptides that are variants, derivatives or structural equivalents of cupredoxins, which retain the ability to inhibit angiogenesis in mammalian cells, tissues or animals. These compositions may be peptides or pharmaceutical compositions, among others. The compositions of the invention may be used to treat any pathological condition that has as a symptom or cause, inappropriate angiogenesis, and particularly inappropriate angiogenesis related to tumor development. | 08-15-2013 |
20140179617 | Cytotoxic Factors For Modulating Cell Death - Cytotoxic factors having use in modulating cell death, and their use in methods of treating necrosis or apoptosis-related conditions are disclosed. The invention also relates to methods for identifying active agents useful in treating conditions related to cell death or uncontrolled growth. The present inventors have found that different microorganisms produce different cytotoxic factor(s) having anticancer activity. The substantially pure cytotoxic factors can be used in a method of treating an infectious disease or a cancer. | 06-26-2014 |
Patent application number | Description | Published |
20130081850 | Fire-Resisting Thermoplastic Composition for Plenum Raceways and Other Conduits - A conduit that contains an elongate member that defines a hollow passageway is provided. The conduit may be used to convey electricity (e.g., jacket of a communication cable, raceway for protecting a communication cable, etc.), fluids (e.g., pipes), etc. In one embodiment, for example, the conduit may be a raceway for use in a plenum of a building structure. Regardless of the type of conduit, at least a portion of the elongate member is formed from a thermoplastic composition that contains a polyarylene sulfide and fire-resisting system. Due in part to the specific nature and concentration of these components, the present inventors have discovered that the resulting thermoplastic composition may have a relatively high melting temperature. | 04-04-2013 |
20130084415 | Electrical Conduit Containing a Fire-Resisting Thermoplastic Composition - An electrical conduit that contains a jacket that defines a hollow passageway is provided. At least a portion of the jacket is formed from a thermoplastic composition that contains a polyarylene sulfide and fire-resisting system. Due in part to the specific nature and concentration of these components, the present inventors have discovered that the resulting thermoplastic composition may have a relatively high melting temperature, such as from about 200° C. to about 500° C. | 04-04-2013 |
20130227759 | Fabrics Containing a Blend of Polyarylene Sulfide and Textile Fibers - A fabric that contains a blend of textile and polyarylene sulfide fibers is provided. At least a portion of the textile fibers, polyarylene sulfide fibers, or a combination thereof are coated with an emulsion copolymer that is crosslinked. The copolymer composition is cured after it is applied to the fibers to initiate the formation of crosslink bonds between the emulsion copolymer and create a three-dimensional network that is capable of coating and encapsulating the fibers. It is believed that this three-dimensional network is able to physically entrap disperse additives when applied to the fibers. Still further, the present inventors have discovered that the emulsion copolymer can uniformly coat the fibers and thus readily receive the additive, which eliminates the need for high temperatures and/or pressures during a dyeing process, for example, and can also result in a relatively uniform coating of the additive on the fibers. | 09-05-2013 |
20130227800 | Polyarylene Sulfide Fibers Containing an Emulsion Copolymer Coating - A fibrous material that contains polyarylene sulfide fibers coated with an emulsion copolymer is provided. The emulsion copolymer that is coated onto the polyarylene sulfide fibers is crosslinked. For example, the copolymer may contain a reactive co-monomer that acts as a crosslinking agent. Alternatively, a separate crosslinking agent may be combined with the emulsion copolymer. In either case, the resulting copolymer composition is cured after it is applied to the fibers to initiate the formation of crosslink bonds between the emulsion copolymer and create a three-dimensional network that is capable of coating and encapsulating the fibers. Without intending to be limited by theory, it is believed that this three-dimensional network is able to physically entrap disperse dyes when applied to the fibers. | 09-05-2013 |
20140178687 | Monofilament Fibers Made From a Polyoxymethylene Composition - A monofilament fiber as described made from a polyoxymethylene polymer. Polyoxymethylene polymer can be blended with an abrasion additive in order to improve abrasion resistance. The polyoxymethylene polymer may be combined with a thermoplastic elastomer and a coupling agent. The fiber can be used as fishing line, as bristles for a brushing device, or the like. | 06-26-2014 |
Patent application number | Description | Published |
20100236929 | Droplet Actuators, Systems and Methods - A droplet actuator with arrays of electrodes electrically coupled to a number of controllable voltage sources that is less than the number of electrodes. A method of defining partitions for pin layouts in a droplet actuator for a specific assay, the method including: defining droplet traces for the assay; and defining a guard ring along the traces. Other methods, systems, droplet actuators, and algorithms are also provided. | 09-23-2010 |
20120062308 | POWER SWITCH DESIGN AND METHOD FOR REDUCING LEAKAGE POWER IN LOW-POWER INTEGRATED CIRCUITS - Power switching circuits and power management techniques are provided that can reduce static power of ICs, including digital core processors. In one embodiment, the power switching circuit includes a footer (power-gating transistor) between the core and a ground rail and at least two additional power-gating transistors parallel to the footer. The power-gating transistors are controlled by respective control signals to enable selective switching. In a specific embodiment, for each sleep mode, at most, a single one of the transistors is turned on. Multiple sleep modes are accomplished according to the relative sizing of the additional power-gating transistors. A larger of the additional transistors is used to provide a standby mode during short idling times by providing a fast wake-up time and some reduction in static power. For standby modes during longer idling periods, smaller sized transistors are turned on. For longest idling periods, all transistors are turned off. | 03-15-2012 |
20130006557 | METHOD AND ARCHITECTURE FOR PRE-BOND PROBING OF TSVs IN 3D STACKED INTEGRATED CIRCUITS - On-chip test architecture and design-for-testability methods for pre-bond testing of TSVs are provided. In accordance with certain embodiments of the invention, a die level wrapper is provided including gated scan flops connected to one end of each TSV. The gated scan flops include a scan flop structure and a gated output. The gated output is controlled by a signal to cause the output of the gated scan flop to either be in a “floated state” or take the value stored in the flip-flop portion of the gated scan flop. The gated output of the gated scan flop can be used to enable resistance and capacitance measurements of pre-bonded TSVs. | 01-03-2013 |
20130105318 | HIGH THROUGHPUT AND VOLUMETRIC ERROR RESILIENT DILUTION WITH DIGITAL MICROFLUIDIC BASED LAB-ON-A-CHIP | 05-02-2013 |
20130105319 | ARCHITECTURAL LAYOUT FOR DILUTION WITH REDUCED WASTAGE IN DIGITAL MICROFLUIDIC BASED LAB-ON-A-CHIP | 05-02-2013 |
20130115703 | DILUTION METHOD FOR DIGITAL MICROFLUIDIC BIOCHIPS - Systems and methods are provided for producing fluids with desired concentration factors. According to one embodiment, a sequence of mix steps comprises mixing a resultant solution of a preceding mix step with one of the input solutions of the preceding mix step depending on a concentration factor of the resultant solution. If the concentration factor of the resultant solution is higher than the target concentration factor, then the resultant solution is mixed with the input solution having the lower concentration factor. If the concentration factor of the resultant solution is lower than the target concentration factor, then the resultant solution is mixed with the input solution having the higher concentration factor. | 05-09-2013 |
20140122951 | SCAN TEST OF DIE LOGIC IN 3D ICs USING TSV PROBING - A test architecture for 3D ICs is provided in which Through-Silicon-Vias and die logic can be tested pre-bonding dies in the stack for the 3D ICs. Post-bond scan test architecture is reconfigured to be accessed during pre-bond testing through using stratigically placed MUXs and TSVs. By connecting post-bond architecture including scan flops and boundary registers to gated scan flops used in TSV testing, an internal chain of scan flops such as typically used in post-bond testing can be selectively connected to gated scan flops connected to one end of each TSV for pre-bond testing of the internal logic through the TSVs. | 05-01-2014 |
20150098110 | Print Production Scheduling - A print production system includes a dispatcher and a task-resource scheduler. The dispatcher sorts print requests for placement among a series of containers to identify relative priorities among all print requests in each container and then merges the containers together to produce a prioritized list of print requests among all containers. Upon release by the dispatcher of a top N print requests from the prioritized list, the scheduler converts the prioritized list into a task-resource schedule for print production. | 04-09-2015 |
20150316605 | SOFTWARE-BASED SELF-TEST AND DIAGNOSIS USING ON-CHIP MEMORY - Embedded processor-based self-test and diagnosis using the compressed test data is described for ICs having on-chip memory. Techniques for compressing the test data before the compressed test data is transferred to a device under test (DUT) are also described. A modified LZ77 algorithm can be used to compress strings of test data in which don't care bits are handled by assigning a value to the don't care bits according to a longest match in the window as the data is being encoded. The compressed test data can be decompressed at the DUT using a software program transferred by the automated test equipment (ATE) to the DUT with the compressed test data. Decompression and diagnostics can be carried out at the DUT using an embedded processor and the on-chip memory. Results from the diagnostics can be read by the ATE. | 11-05-2015 |
Patent application number | Description | Published |
20090056535 | PARTICLE SEPARATION - Embodiments of a method for selecting particles, such as based on their morphology, is disclosed. In a particular example, the particles are charged and acquire different amounts of charge, or have different charge distributions, based on their morphology. The particles are then sorted based on their flow properties. In a specific example, the particles are sorted using a differential mobility analyzer, which sorts particles, at least in part, based on their electrical mobility. Given a population of particles with similar electrical mobilities, the disclosed process can be used to sort particles based on the net charge carried by the particle, and thus, given the relationship between charge and morphology, separate the particles based on their morphology. | 03-05-2009 |
20100057421 | AGGREGATE SIMULATION - The present disclosure provides, among other things, a method for generating a simulated aggregate based on one or more input parameters. A test aggregate is constructed and rotated. Stable orientations of the aggregate on a surface are determined. In specific examples, two-dimensional properties are calculated for stable orientations of the test aggregate and stored or displayed. In particular implementations of the method, the test aggregate is constructed through successive monomer addition. | 03-04-2010 |
20100224479 | MORPHOLOGY ENGINEERING OF AGGREGATES - In various embodiments, the present disclosure provides, among other things, a system and method for influencing the morphology of aggregates. The present disclosure also provides for aggregates formed using the disclosed system and method. According to one disclosed method, a plurality of monomers are provided and an electric field is applied proximate the monomers. The applied fields helps influence the shape of an aggregate formed from the monomers. | 09-09-2010 |
Patent application number | Description | Published |
20090068671 | Binding method and apparatus for sorting objects - The present invention relates to a method and apparatus of sorting objects including, providing a sample having wanted objects and unwanted objects; coating a surface of a sample holder with an antibody; placing an eluted sample on the sample holder; binding an antigen in the wanted objects with the antibody on the surface of the sample holder to sort the objects into wanted objects and unwanted objects; separating the wanted objects; and performing PCR-based STR analysis on the wanted objects. In one embodiment, holographic optical trapping is used to further sort the wanted objects. In other embodiments, the wanted objects are sperm and the antibody is a human sperm specific antibody, and the PCR is single cell PCR-based STR analysis. In still other embodiments, the binding is direct or indirect, ligands are used to bind to object-specific organomolecules, and protein A or protein G are used to bind the antibody. | 03-12-2009 |
20090075826 | Methods and apparatuses for sorting objects in forensic DNA analysis and medical diagnostics - The present invention relates to an apparatus and method of sorting objects and identifying the objects in a forensics sample, including using holographic optical trapping to sort objects from contaminants, and performing (single cell) PCR-based STR analysis on the objects to determine their identification. In addition, the chip used as a support for sorting the objects can also be used for performing single cell PCR-based STR analysis. In another embodiment, a microfluidics chip is used to stream the sample and sort the objects, before single cell PCR-based STR analysis is performed. The chip used for sorting utilizing HOT in the absence or presence of microfluidic streaming and sorting can also be the same as that used for the single cell PCR-based STR analysis. | 03-19-2009 |
20110026009 | Surface Mapping by Optical Manipulation of Particles in Relation to a Functionalized Surface - Methods and apparatus for analyzing surface properties of particles are provided. A method for analyzing the surface properties of the particle includes a associating a first particle with a first capture zone having a specific binding affinity for a first chemical species, applying an optical force to the first particle, sensing a response of the first particle to the optical force, and using the sensed response to determine the presence, absence or quantity of the first chemical species on the first particle surface. This process may be repeated in parallel to test multiple particles. In addition to directly testing the surface properties of the particles, the method can be used in direct, indirect and competitive assays to determine the presence, absence or quantity of free or immobilized analytes. A fluidic cartridge with capture zones having avidities that are tuned for the use of optical forces is provided. A software routine for performing the method is also provided. | 02-03-2011 |
20110177547 | Particle Sorting Using Fluid Streams - A fluidic device includes an arrangement of channels for introducing a sample containing particles of interest into a processing chamber. The chamber is in fluid communication with collecting channels via low-flow connection channels. Particles in the sample may be observed and diverted from the processing chamber by application of a motive force such as optical trapping into a collection channel. Once in the collection channel, particles can be collected, including by trapping in a porous matrix. | 07-21-2011 |
20110223653 | Method and apparatuses for sorting objects in forensic DNA analysis and medical diagnostics - The present invention relates to an apparatus and method of sorting objects and identifying the objects in a forensics sample, including using holographic optical trapping to sort objects from contaminants, and performing (single cell) PCR-based STR analysis on the objects to determine their identification. In addition, the chip used as a support for sorting the objects can also be used for performing single cell PCR-based STR analysis. In another embodiment, a microfluidics chip is used to stream the sample and sort the objects, before single cell PCR-based STR analysis is performed. The chip used for sorting utilizing HOT in the absence or presence of microfluidic streaming and sorting can also be the same as that used for the single cell PCR-based STR analysis. | 09-15-2011 |
20120028848 | Binding method and apparatus for sorting objects - The present invention relates to a method and apparatus of sorting objects including, providing a sample having wanted objects and unwanted objects; coating a surface of a sample holder with an antibody; placing an eluted sample on the sample holder; binding an antigen in the wanted objects with the antibody on the surface of the sample holder to sort the objects into wanted objects and unwanted objects; separating the wanted objects; and performing PCR-based STR analysis on the wanted objects. In one embodiment, holographic optical trapping is used to further sort the wanted objects. In other embodiments, the wanted objects are sperm and the antibody is a human sperm specific antibody, and the PCR is single cell PCR-based STR analysis. In still other embodiments, the binding is direct or indirect, ligands are used to bind to object-specific organomolecules, and protein A or protein G are used to bind the antibody. | 02-02-2012 |