Cowan, US
Ada S. Cowan, Delaware, OH US
Patent application number | Description | Published |
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20120289454 | METALLODRUGS HAVING IMPROVED PHARMACOLOGICAL PROPERTIES, AND METHODS OF MANUFACTURE AND USE THEREOF - It is an object of the present invention to provide improved pharmacological properties to molecules which bind to a target with low affinity (hereinafter referred to as a “ligand moiety”) through linkage of such molecules to a metal binding moiety, thereby generating a combination molecule commonly referred to as a “metallodrug” or “metallotherapeutic.” The metal binding domain of metallodrugs typically catalyzes oxido-reductase chemistry or acts as a Lewis-Acid catalyst, resulting in modification of proteins and nucleic acids that are in close proximity due to binding of the ligand moiety to its target. | 11-15-2012 |
20130210705 | METALLODRUGS HAVING IMPROVED PHARMACOLOGICAL PROPERTIES AND METHODS OF MANUFACTURE AND USE THEREOF - It is an object of the present invention to provide antimicrobial metallodrugs comprising an antimicrobial peptide (“AMP”) and/or an antibiotic covalently bound to a metal binding moiety. These metallodrugs combine a metal binding domain which typically catalyzes oxido-reductase chemistry or acts as a Lewis-Acid catalyst, with a member of a diverse class of antimicrobial agents currently validated in preclinical and clinical settings for the treatment of a broad spectrum of pathogenic organisms. | 08-15-2013 |
20140377289 | Metallodrugs Having Improved Pharmacological Properties, and Methods of Manufacture and Use Thereof - It is an object of the present invention to provide improved pharmacological properties to molecules which bind to a target with low affinity (hereinafter referred to as a “ligand moiety”) through linkage of such molecules to a metal binding moiety, thereby generating a combination molecule commonly referred to as a “metallodrug” or “metallotherapeutic.” The metal binding domain of metallodrugs typically catalyzes oxido-reductase chemistry or acts as a Lewis-Acid catalyst, resulting in modification of proteins and nucleic acids that are in close proximity due to binding of the ligand moiety to its target. | 12-25-2014 |
Ada S. Cowan, Liberty Township, OH US
Patent application number | Description | Published |
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20110014676 | PROTEIN STABILIZATION - A method and formulation for temperature stabilization of proteins, such as antibodies, enzymes such as Taq poly-merase, restriction enzymes, and other diagnostic or therapeutic enzymes using a combination of first and second stabilizers. | 01-20-2011 |
Ada S. Cowan, Lewis Center, OH US
Patent application number | Description | Published |
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20080259519 | Highly-Aqueous, Non-Respirable Aerosols Containing Biologically-Active Ingredients, Method of Making, and Device Therefor - A non-respirable aerosol, particularly a non-respirable aerosol comprising a biologically-effective amount of a biologically-active agent dissolved, emulsified, or suspended in a highly-aqueous liquid carrier vehicle. The highly-aqueous liquid carrier vehicle comprises about 60 wt % to about 100 wt % water, about 0 wt % to about 40 wt % of a co-solvent, about 0.05 wt % to about 10 wt % of an acceptable surfactant, and about 0 wt % to about 10 wt % of an excipient. The non-respirable aerosol is substantially monodisperse when dispensed from a sprayhead assembly comprising a preferably linear array of a plurality of nozzles and at least one counter electrode adapted to substantially equalize the charge fields of the plurality of nozzles. | 10-23-2008 |
Alex Cowan, Phoenix, AZ US
Patent application number | Description | Published |
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20120055820 | GOLF BAGS WITH RETENTION SYSTEM AND METHODS TO MANUFACTURE GOLF BAGS - Embodiments of golf bags with an extensible bag stand having a retention system and methods to manufacture golf bags are generally described herein. Other embodiments of golf bags with an extensible bag stand having a retention system may be described and claimed. | 03-08-2012 |
Alexander Cowan, Anthem, AZ US
Patent application number | Description | Published |
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20120055819 | GOLF BAGS WITH RETENTION SYSTEM AND METHODS TO MANUFACTURE GOLF BAGS - Embodiments of golf bags with an extensible bag stand having a retention system and methods to manufacture golf bags are generally described herein. Other embodiments of golf bags with an extensible bag stand having a retention system may be described and claimed. | 03-08-2012 |
Anthony J. Cowan, Ocala, FL US
Patent application number | Description | Published |
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20110164514 | Transmit Power Control - A method for communicating among nodes in a network includes determining, by a transmitter, a first frequency band and at least a second frequency band to be used for communicating data packets, wherein a maximum allowable power spectral density in the first frequency band is greater than a maximum allowable power spectral density in the second frequency band. The method also includes adjusting power spectral density for a first group of frequencies in the first frequency band such that the adjusted power spectral density of the first group does not exceed the maximum allowable power spectral density of the first frequency band and a quantization noise introduced by the transmitter is less than a threshold value for a signal transmitted in the second frequency band. The method further includes modulating at least a portion of a data packet transmitted by the transmitter to at least a first receiver in accordance with the adjusted power spectral density. | 07-07-2011 |
20110176463 | MANAGING POWER STATES IN NETWORK COMMUNICATIONS - Controlling a power state of a communications device includes: receiving over a network at a communications device in a low-power mode from a scheduling device an assignment of a power state schedule indicating one or more intervals to enter an active state period and one or more intervals to enter a sleep state period; and during an active state period at the communications device, receiving over the network from a second communications device aware of the power state schedule a request that the communications device exit the low-power mode. | 07-21-2011 |
Antony L. Cowan, Issaquah, WA US
Patent application number | Description | Published |
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20090210796 | System and Method for Dynamically Modifying a Sequence of Slides in a Slideshow Set During a Presentation of the Slideshow - A system and method for dynamically modifying a sequence of slides in a slideshow set during a presentation of the slideshow are provided. Tag metadata may be provided for each slide of a slideshow set such that this tag metadata may be used to establish logical subsets of slides within the slideshow set. Options may be provided for a user to select an interface item to obtain slides, from the current slideshow set or another slideshow set, that are associated with a currently displayed slide in the slideshow set. User interface items may be provided through which the user may temporarily redirect the sequence of the original slideshow set to incorporate one or more of these related slides and, upon termination of this “detour”, may return to the point at which the sequence diverted. | 08-20-2009 |
Ben Cowan, Memphis, TN US
Patent application number | Description | Published |
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20100222825 | SIDE-LOADING OCCIPITAL VERTEBRAL FIXATION SYSTEM - An occipital plating system includes a fixation assembly with a plate and a coupling member extending from a respective one of opposite lateral portions of the plate. The coupling members each include a passage that opens in at least one of a medial or lateral direction to receive a connecting element extending from the spinal column. | 09-02-2010 |
Benjamin Cowan, Memphis, TN US
Patent application number | Description | Published |
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20120197313 | Angled Receiver Wall for Provisionally Fixing a Crown in a Multi-Axial Screw Assembly - A multi-axial screw assembly comprises a bone anchoring member, a receiver, a crown and a snap ring. The receiver member has an aperture extending along a central axis of the receiver member. The aperture receives the bone anchoring member. The receiver member has a cutout on an interior wall of the receiver member. The cutout has an angled wall surface. The angled wall surface extends along the central axis of the receiver. The crown is configured to be received within the receiver member along the central axis of the receiver member. The crown has a groove around the circumference of the crown. The snap ring is configured to be received in the groove of the crown and in the cutout in the receiver member. The snap ring exerts an axial force on the crown when the snap ring abuts the angled wall surface of the receiver member. | 08-02-2012 |
Benjamin D. Cowan, Memphis, TN US
Patent application number | Description | Published |
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20110106164 | APPARATUS FOR IMPLEMENTING A SPINAL FIXATION SYSTEM WITH SUPPLEMENTAL FIXATION - An apparatus for implementing a spinal fixation system with supplemental fixation includes a spinal fixation rod assembly and at least one supplemental fixation device. The spinal fixation rod assembly is adapted to provide primary fixation at a plurality of first fixation points by being secured to a plurality of first vertebral components except not into one of the first vertebral components of the plurality that is in a weakened structural condition and located between other of the first vertebral components of the plurality. The supplemental fixation device is adapted to provide supplemental fixation for the assembly at a second fixation point by being secured to a second vertebral component located adjacent to and offset from the one first vertebral component in the weakened structural condition and also to interconnect with the assembly to provide anchorage and thus additional fixation supplemental to the primary fixation. | 05-05-2011 |
Benjamin David Cowan, Memphis, TN US
Patent application number | Description | Published |
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20090240208 | Microparticle delivery syringe and needle for placing particle suspensions and removing vehicle fluid - A syringe having two or more chambers having a needle defining two or more lumens for injecting a microparticle suspension into a desired space, the lumens being in fluid communication with respective chambers. One of the chambers has the microparticle suspension disposed therein while the other chamber is empty. The lumen in fluid communication with the empty chamber has a filter element disposed therein such that the suspension fluid may be withdrawn from the space into the empty chamber without withdrawing the microparticles. | 09-24-2009 |
20110106085 | ADJUSTABLE OCCIPITAL VERTEBRAL FIXATION SYSTEM - An occipital plating system includes a plating assembly with a plate body defining a profile adapted for positioning on the occiput. The plate body includes a central portion that extends bi-laterally across the central axis of the spinal column to opposite lateral portions of the plate. At least one coupling member extends from each of the lateral portions of the plate body to receive a connecting element extending from the spinal column. | 05-05-2011 |
Bryan W. Cowan, Bay City, MI US
Chad Cowan, Boston, MA US
Patent application number | Description | Published |
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20110195056 | COMPOSITIONS COMPRISING HEPATOCYTE-LIKE CELLS AND USES THEREOF - The invention generally features methods for generating hepatocytes from a variety of pluripotent stem cells, including adipose mesenchymal stem cells, therapeutic compositions featuring such cells, and methods of using them for the treatment of subjects. | 08-11-2011 |
20120219530 | COMPOSITIONS AND METHODS OF GENERATING REPROGRAMMED ADIPOCYTE CELLS AND METHODS OF USE THEREFORE - The invention provides therapeutic compositions comprising reprogrammed adipocyte cells for use as disease models, therapeutic compositions comprising reprogrammed adipocyte cells for the treatment of conditions characterized by a reduction in cell number or tissue mass, and methods of generating such cells. | 08-30-2012 |
Christopher James Cowan, Wixom, MI US
Patent application number | Description | Published |
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20080284224 | VEHICLE SEAT - A vehicle seat for coupling to the floor of a vehicle comprising a seat back, a seat cushion, a first bracket, and a second bracket. The seat back is pivotable between at least a first position and a design position. The seat cushion is configured to be coupled to the vehicle floor. The first bracket is configured to be coupled to the vehicle floor and includes one of a keyed passage and a keyed pin configured to be received within the keyed passage. The second bracket is coupled to the seat back and includes the other one of the keyed passage and the keyed pin configured to be received within the keyed passage. The keyed passage is configured to receive the keyed pin only when the seat back is in a position the seat back will be prevented from assuming after the vehicle seat has been installed in the vehicle. | 11-20-2008 |
Clarence E. Cowan, Newberg, OR US
Patent application number | Description | Published |
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20080252316 | Membrane probing system - A membrane probing assembly includes a probe card with conductors supported thereon, wherein the conductors include at least a signal conductor located between a pair of spaced apart guard conductors. A membrane assembly includes a membrane with contacts thereon, and supporting at least a signal conductor located between a pair of spaced apart guard conductors. The guard conductors of the probe card are electrically interconnected proximate the interconnection between the probe card and the membrane assembly. The guard conductors of the membrane assembly are electrically interconnected proximate the interconnection between the probe card and the membrane assembly. | 10-16-2008 |
Crispin Cowan, Bellevue, WA US
Patent application number | Description | Published |
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20090300532 | CONVEYING PRIVILEGE ESCALATION TO USERS - Techniques, systems, and apparatuses for conveying privilege escalation to a user are disclosed. In some aspects, a privilege escalation request is initiated in a first operating environment. The first operating environment may foreshorten to reveal a second operating environment associated with the privilege escalation. The second operating environment includes a continuous visual presentation to alert the user of the privilege escalation. A user may complete one or more privileged activities in the second operating environment before returning to the first operating environment. | 12-03-2009 |
20110154505 | UNOBTRUSIVE ASSURANCE OF AUTHENTIC USER INTENT - Computer-executable instructions that are directed to the performance of consequential actions and automatically elevate to execute at a higher privilege level to do so can perform such consequential actions only after user notification. Doing so can enable monitoring processes to avoid presenting duplicative user notification upon detection of such auto-elevation. In addition, prior to presenting user notification, input from the execution environment can be ignored and access to DLLs for performing consequential actions can be avoided. A static analyzer can identify non-conforming computer-executable instructions. A wrapper can be utilized to provide compliance by otherwise unknown or non-conforming computer-executable instructions. | 06-23-2011 |
Crispin Cowan, Fall City, WA US
Patent application number | Description | Published |
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20110307831 | User-Controlled Application Access to Resources - A host application on a computing device displays an icon or other visual representation of a resource of the computing device, and receives a request from one of one or more applications hosted by the host application. The request is a request to access the resource represented by the icon or other visual representation of the resource, and in response to the request the appearance of the icon or other visual representation of the resource is altered. The requesting application is allowed to access the resource only if a user selection of the displayed icon or other visual representation is received. | 12-15-2011 |
20120192275 | REPUTATION CHECKING OF EXECUTABLE PROGRAMS - The reputation of an executable computer program is checked when a user input to a computing device initiates a program launch, thus triggering a check of a local cache of reputation information. If the local cache confirms that the program is safe, it is permitted to launch, typically without notifying the user that a reputation check has been made. If the local cache cannot confirm the safety of the program, a reputation check is made by accessing a reputation service in the cloud. If the reputation service identifies the program as safe, it returns an indication to the computing device and the program is permitted to be launched, again without notifying the user that a reputation check has been made. If the reputation service identifies the program as unsafe or potentially unsafe, or does not recognize it at all, a warning is displayed to the user. | 07-26-2012 |
Cristopher Cowan, Fitchburg, WI US
Patent application number | Description | Published |
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20110088491 | HEATING, SHAKING, AND MAGNETIZING APPARATUS AND METHOD OF OPERATING THE SAME - An apparatus for processing a liquid sample in a sample tube. The apparatus includes a base, a receptacle for receiving a sample tube, and a heating portion coupled to the base to selectively apply heat to the receptacle. A shaking portion is coupled to the base and supports the receptacle. The shaking portion selectively agitates the receptacle with respect to the base. A magnetizing portion is coupled to the base and movable to selectively change a magnetic field with respect to the receptacle. | 04-21-2011 |
20110178286 | CONSUMABLE ANALYTICAL PLASTICWARE COMPRISING HIGH-SOLUBILITY PLASTICS - Consumable analytical plasticware comprising polymers having solubility parameters of about 9.5 (cal/cm | 07-21-2011 |
20140030169 | HEATING, SHAKING, AND MAGNETIZING APPARATUS AND METHOD OF OPERATING THE SAME - An apparatus for processing a liquid sample in a sample tube. The apparatus includes a base, a receptacle for receiving a sample tube, and a heating portion coupled to the base to selectively apply heat to the receptacle. A shaking portion is coupled to the base and supports the receptacle. The shaking portion selectively agitates the receptacle with respect to the base. A magnetizing portion is coupled to the base and movable to selectively change a magnetic field with respect to the receptacle. | 01-30-2014 |
Curtis C. Cowan, E. Hampton, CT US
Patent application number | Description | Published |
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20090065610 | Rollertrack pivoting axi-nozzle - A mechanism included in a convergent-divergent nozzle connected to an aftward portion of a gas turbine engine, which mechanism includes at least one actuator configured to be connected to the aftward portion of the engine and to move through one or more positions, a first link pivotally connected to the at least one actuator, a convergent flap pivotally connected to the first link, a divergent flap rotatably connected to the convergent flap and configured to be kinematically connected to an annular ring connected to the at least one actuator, and at least one track configured to extend from the aftward portion of the engine and to movably and pivotally receive the pivotal connection between the convergent flap and the first link. | 03-12-2009 |
20130001319 | IMPINGEMENT COOLED NOZZLE LINER - A nozzle liner for a rotatable nozzle includes a seal land and a rotatable seal for moving with the nozzle. The seal has a first diffusion hole for distributing cooling air if the rotatable seal is in a first position and a second diffusion hole for distributing cooling air if the rotatable seal is in a first position and if in a second position. | 01-03-2013 |
Curtis C. Cowan, East Hampton, CT US
Patent application number | Description | Published |
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20090072490 | Convergent Divergent Nozzle with Edge Cooled Divergent Seals - A nozzle system includes a multitude of circumferentially distributed divergent seals that circumscribe an engine centerline. Each divergent seal includes a multiple of divergent seal intakes adjacent to a joint structure to receive cooling airflow. Each divergent seal body is manufactured of a metallic hot sheet inner skin and a metallic cold sheet outer skin. The skins form a multiple of longitudinal channels which communicate with a multiple of edge channels formed within the first longitudinal side and the second longitudinal side of each divergent seal. The multiple of edge channels are located transverse to the longitudinal axis and are raked aft to facilitate cooling of the gas path surface of each divergent seal and adjacent divergent flaps. | 03-19-2009 |
20110308254 | Turbine Engine Fuel Injector - A gas turbine engine is piloted with a pilot flow of fuel delivered to a combustor as a liquid. A first additional flow of the fuel is also delivered to the combustor as a liquid. A second additional flow of the fuel is vaporized and delivered to the combustor as a vapor. A fuel injector may have passageways associated with each of the three flows. | 12-22-2011 |
Daniel P. Cowan, Kansas City, MO US
Patent application number | Description | Published |
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20110054936 | PATIENT INTERACTIVE HEALING ENVIRONMENT - Systems, methods, and computer-readable media for providing an interactive healing environment to a patient are provided. Servers in a network may operate a set of modules to communicate with a client device of the patient. The set of modules may operate to enhance communication between the patient and the healthcare providers of patient in the healthcare facility. The modules may also interact with medical devices associated with the patient. The medical devices may be connected to a component, such as a bus, that receives data from the medical devices and determines where the data should be sent. | 03-03-2011 |
David Cowan, Cornwall Bridge, CT US
Patent application number | Description | Published |
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20090107578 | TIRE SEALANT DISPENSING APPARATUS - A tire-sealing apparatus for injecting a sealing composition into a vehicle tire either as a prophylactic or for sealing an existing leak is in the form of a pressurizeable container for a flowable sealant compound. An inlet is provided for introducing compressed gas into the container to pressurize its contents. An outlet line is also provided to deliver the sealant into a tire, the pressurized gas acting on contents of the container and providing the motive force for the delivery. A dip tube extends into the compound and is coupled to a one-way valve to provide a controlled flow of the compound from the container into the tire while preventing back pressure of the tire from either delivering air or compound back into the container. A passageway between the outlet tube and an interior of the container is provided to allow a flow of compressed gas within the container into the outlet tube along with the sealant. | 04-30-2009 |
David Cowan, Brooklyn, NY US
Patent application number | Description | Published |
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20090075505 | Electrical switch and outlet design that can be safely replaced with the power on and without tools - An electrical switch and outlet design which includes a modular electrical component system having a universal connector which can receive replacement switches, sockets and other electrical components. The connection between these switches, sockets or other components and the universal connector is controlled by a lifting system in which the entirety of the replacement module is inserted into a receptacle or removed therefrom without the user touching any electrical wiring. Essentially, components are changed by plugging a component into and unplugging one from a universal grounded connector. | 03-19-2009 |
David E. Cowan, Cleveland, OH US
Patent application number | Description | Published |
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20100034584 | BARRIERS WITH KISS-OFFS - A barrier includes a housing having a front wall and an opposing back wall each extending between opposing sidewalls. The housing also includes a floor and an interior surface bounding a chamber, the chamber communicating externally through an inlet opening. A first inset projects into the chamber from the front wall so as to form a recessed pocket on the front wall. A second inset projects into the chamber from the back wall so as to form a recessed pocket on the back wall. The first inset and the second inset are connected together within the chamber so that the chamber encircles the connection. | 02-11-2010 |
David John Cowan, Hillsborough, NC US
David John Cowan, Durham, NC US
Patent application number | Description | Published |
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20080255124 | Chemical Compounds - This invention relates to non-steroidal compounds that are modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds. | 10-16-2008 |
20090163588 | ANILINE DERIVATIVES AS SELECTIVE ANDROGEN RECEPTOR MODULATORS - This invention relates to non-steroidal compounds that are modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds. | 06-25-2009 |
David M. Cowan, Brooklyn, NY US
Patent application number | Description | Published |
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20120121310 | COSMETIC BRUSH APPLICATOR SYSTEM - An integrated cosmetic brush applicator system having both a brush section and reservoir section in which the brush can be pushed to an extended applicator position moveable out from the brush section an automatically pushed back into a retracted storage position when the brush section is tightly connected to the reservoir section. A push button assembly enables the brush to manually be pushed out from its retracted to an extended position permitting the brush to be used to apply cosmetic material. The brush is in contact with the reservoir section to allow cosmetic material to coat the brush when the system is in the closed position. | 05-17-2012 |
David M. Cowan, Cornwall Bridge, CT US
Patent application number | Description | Published |
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20110103065 | Lighting Fixture With Improved Mounting Arrangements For Mounting A Reflector And Accessories - A specialized lighting fixture comprised of a main housing and a front bezel, wherein a pair of multifunctional clip elements are mounted in the bezel and serve to secure and position therein one or more filters and a reflector, such that the filters and reflector can be installed and removed as a unit with the bezel to facilitate changeovers. The multifunctional clip elements also include elements for mounting the bezel to the main housing with a quick, fractional rotation of the bezel, providing a secure detent action for retention of the bezel. The bezel includes support surfaces that function, together with the multifunctional clip elements to accurately position the reflector with respect to the bezel and the bezel with respect to the main housing, for achieve an optimum level of operating efficiency of the fixture. | 05-05-2011 |
Deborah J. Cowan, Scottsdale, AZ US
Patent application number | Description | Published |
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20100221144 | AIR FRESHENER KIT - The present invention comprises a kit for assembling a passive air freshener comprising fragranced sail crystals. In the preferred form, the kit minimally comprises: 1) a package containing a plurality of fragranced salt crystals; 2) a container with an opening for placing said crystals therein, said container defining an enclosed space having a height/width ratio of from about 0.5 to about 3; and, 3) a carton for containing both the package of crystals and the container, where the carton preferably has a viewing window that displays at least the decorative aspects of the container design to potential purchasers. The kit may also include instructional literature and optional lighting source. | 09-02-2010 |
20110011947 | GEL AIR FRESHENER AND METHOD OF UNSEALING SUCH GEL AIR FRESHENER - The present invention is a gel air freshener article of manufacture comprising a gel air freshener composition and a container that provides a method for unsealing and opening without undue exertion by the consumer. The article of manufacture according to the present invention includes the gel air freshener composition and a container comprising a base portion and axially displaceable cover in telescopic registry, wherein the cover is axially displaced away from the base portion by rotation. The unsealing of the container is achieved through the coordination of camming locks, which comprise an upper ramped surface, with spike-shaped locking wedges that comprise a beveled toe portion, elongated shaft portion and camming head portion. Rotation of the cover in a first direction relative to the base portion locks the toe end and shaft portions of the spike-shaped locking wedges beneath the camming locks. Rotation in a second opposite direction relative to the base portion backs the camming head portion of the spike-shaped wedges up the upper ramped surfaces of the camming locks such that the cover is axially distanced from the container, thus unsealing the cover from the base and breaking loose the gel air freshener composition bound inside surface of the cover. An optional pin-hole in the cover allows for pressure equalization of the momentary vacuum created when the cover is first unsealed and displaced. | 01-20-2011 |
Frederick K. Cowan, Tucson, AZ US
Patent application number | Description | Published |
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20100218495 | SYSTEMS AND DEVICES FOR STORING ENERGY IN AN ELASTIC ROPE SPRING MOTOR - Systems and devices for storing mechanical energy in a spring motor or the like are described. In one implementation, an energy storage device includes an elastic rope, a spool and a control mechanism. The elastic rope is reversibly deformable from a relaxed state to a stretched state for storing mechanical energy. The spool is coupled to the elastic rope, and is configured to maintain the elastic rope in the stretched state while the elastic rope is wound around the spool. The control mechanism is coupled to the spool and is configured to allow the spool to rotate in response to the elastic rope relaxing from the stretched state to the relaxed state for retrieval of stored mechanical energy. In some implementations, the elastic rope may be formed from an elastomer wrapped with a fiber made from carbon nanotubes or other synthetic strengthening material. | 09-02-2010 |
Fred M. Cowan, Colora, MD US
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20110305779 | PHYTOCHEMICAL COMBINATIONS THAT REGULATE PATHOLOGICAL IMMUNITY - Disclosed are dietary supplements comprising a combination of a spice, a partially purified phytochemical, and a fully purified phytochemical that synergistically downregulates inflammation and promotes wellness, good health, and fitness in a mammal. Methods of identifying and making such supplements are likewise provided. The method of identifying comprises contacting mammalian cells, in vitro or in vivo, with the combination, assaying to detect a change in the level of a biomarker that is correlated with downregulation of an inflammatory response of the cells, and identifying a phytochemical composition comprising a combination of spices that synergistically changes the level of the biomarker. Exemplary supplements include a combination of spices selected from (a) turmeric and ginger, (b) turmeric and | 12-15-2011 |
James A. Cowan, Delaware, OH US
Patent application number | Description | Published |
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20120289454 | METALLODRUGS HAVING IMPROVED PHARMACOLOGICAL PROPERTIES, AND METHODS OF MANUFACTURE AND USE THEREOF - It is an object of the present invention to provide improved pharmacological properties to molecules which bind to a target with low affinity (hereinafter referred to as a “ligand moiety”) through linkage of such molecules to a metal binding moiety, thereby generating a combination molecule commonly referred to as a “metallodrug” or “metallotherapeutic.” The metal binding domain of metallodrugs typically catalyzes oxido-reductase chemistry or acts as a Lewis-Acid catalyst, resulting in modification of proteins and nucleic acids that are in close proximity due to binding of the ligand moiety to its target. | 11-15-2012 |
20130210705 | METALLODRUGS HAVING IMPROVED PHARMACOLOGICAL PROPERTIES AND METHODS OF MANUFACTURE AND USE THEREOF - It is an object of the present invention to provide antimicrobial metallodrugs comprising an antimicrobial peptide (“AMP”) and/or an antibiotic covalently bound to a metal binding moiety. These metallodrugs combine a metal binding domain which typically catalyzes oxido-reductase chemistry or acts as a Lewis-Acid catalyst, with a member of a diverse class of antimicrobial agents currently validated in preclinical and clinical settings for the treatment of a broad spectrum of pathogenic organisms. | 08-15-2013 |
20140377289 | Metallodrugs Having Improved Pharmacological Properties, and Methods of Manufacture and Use Thereof - It is an object of the present invention to provide improved pharmacological properties to molecules which bind to a target with low affinity (hereinafter referred to as a “ligand moiety”) through linkage of such molecules to a metal binding moiety, thereby generating a combination molecule commonly referred to as a “metallodrug” or “metallotherapeutic.” The metal binding domain of metallodrugs typically catalyzes oxido-reductase chemistry or acts as a Lewis-Acid catalyst, resulting in modification of proteins and nucleic acids that are in close proximity due to binding of the ligand moiety to its target. | 12-25-2014 |
James A. Cowan, Wildwood, MO US
Patent application number | Description | Published |
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20090320263 | METHODS AND SYSTEMS FOR MANUFACTURING AN AXLE - A method for manufacturing an axle is provided. The method includes heating a billet at a heating station to a predetermined temperature, forging the heated billet at a forging station to form an axle, and machining the axle at a machining station to form a machined axle. A product is automatically transported to and from each station using a product transport system, wherein the product includes the billet, the axle and the machined axle. | 12-31-2009 |
20120144635 | METHODS AND SYSTEMS FOR MANUFACTURING AN AXLE - A continuous system for automatically manufacturing an axle is provided. The system includes a plurality of sub-systems and an automated transport system. The plurality of sub-systems includes a furnace configured to heat a billet to a predetermined forging temperature, a forging system configured to forge an axle from a heated billet, and a machining system configured to form a machined axle from said axle. The automated transport system is configured to automatically transport a product to and from each of the plurality of sub-systems. The product includes the billet, the axle, and the machined axle. | 06-14-2012 |
James J. Cowan, Lexington, MA US
Patent application number | Description | Published |
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20080309996 | Surface Relief Volume Reflective Diffractive Structure - Disclosed is a surface relief structure. The structure includes a recording medium configured to be structurally modified when exposed to interfering and non-interfering portions of radiation beams, the structurally modified recording medium including, when viewed in a two-dimensional cross-section along one of the axes of the recording medium a plurality of equally spaced steps of fine-sized periodicity superimposed upon a plurality of deep depressions of substantially coarse-sized periodicity. The structurally modified recording medium is configured to produce in reflection single and multiple colors in a broad spectral range when illuminated by a source of light. | 12-18-2008 |
20120300272 | SURFACE RELIEF VOLUME REFLECTIVE DIFFRACTIVE STRUCTURE - Disclosed is a surface relief structure. The structure includes a recording medium configured to be structurally modified when exposed to interfering and non-interfering portions of radiation beams, the structurally modified recording medium including, when viewed in a two-dimensional cross-section along one of the axes of the recording medium a plurality of equally spaced steps of fine-sized periodicity superimposed upon a plurality of deep depressions of substantially coarse-sized periodicity. The structurally modified recording medium is configured to produce in reflection single and multiple colors in a broad spectral range when illuminated by a source of light. | 11-29-2012 |
Jody L. Cowan, Monroe, NC US
Patent application number | Description | Published |
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20100071684 | SOLAR PANEL ADJUSTMENT MECHANISM - The present invention provides methods and systems for a solar panel adjustment device, including a solar panel having a first end and a second end for receiving sunlight, a first pivot frame engaged to the first end of the solar panel for adjusting the solar panel, a second pivot frame engaged to the second end of the solar panel for adjusting the solar panel, and at least one drive means for adjusting the first pivot frame and the second pivot frame independently of one another | 03-25-2010 |
Joe P. Cowan, Fort Colins, CO US
Patent application number | Description | Published |
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20120030401 | MAPPING NON-PREFETCHABLE STORAGE LOCATIONS INTO MEMORY MAPPED INPUT/OUTPUT SPACE - A system including a host and a device. The device has at least one non-prefetchable storage location. The host and the device are configured to map the at least one non-prefetchable storage location into memory mapped input/output space that is addressed via greater than 32 address bits. | 02-02-2012 |
John Cowan, Orlando, FL US
Patent application number | Description | Published |
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20100253855 | CONTINUOUS EXTENDED RANGE IMAGE PROCESSING - Methods and systems for image processing are provided. A method for processing images of a scene includes receiving image data of a reference and a current frame; generating N motion vectors that describe motion of the image data within the scene by computing a correlation function on the reference and current frames at each of N registration points; registering the current frame based on the N motion vectors to produce a registered current frame; and updating the image data of the scene based on the registered current frame. Optionally, registered frames may be oversampled. Techniques for generating the N motion vectors according to roll, zoom, shift and optical flow calculations, updating image data of the scene according to switched and intermediate integration approaches, re-introducing smoothed motion into image data of the scene, re-initializing the process, and processing images of a scene and moving target within the scene are provided. | 10-07-2010 |
20100254572 | CONTINUOUS EXTENDED RANGE IMAGE PROCESSING - Methods and systems for image processing are provided. A method for processing images of a scene includes receiving image data of a reference and a current frame; generating N motion vectors that describe motion of the image data within the scene by computing a correlation function on the reference and current frames at each of N registration points; registering the current frame based on the N motion vectors to produce a registered current frame; and updating the image data of the scene based on the registered current frame. Optionally, registered frames may be oversampled. Techniques for generating the N motion vectors according to roll, zoom, shift and optical flow calculations, updating image data of the scene according to switched and intermediate integration approaches, re-introducing smoothed motion into image data of the scene, re-initializing the process, and processing images of a scene and moving target within the scene are provided. | 10-07-2010 |
John Cowan, Charlotte, NC US
Patent application number | Description | Published |
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20110282817 | ORGANIZATION-SEGMENT-BASED RISK ANALYSIS MODEL - Apparatus and methods for reducing infrastructure failure rates. The apparatus and methods may compile and store data related to the organizational segments associated with the approval and implementation of an infrastructure change. Variables may be derived from the data using a range of methods, and multiple variable values may be consolidated. A model may be developed based on the values and relationships of the derived variables. The model may be applied to assess the risk involved in a prospective infrastructure change. | 11-17-2011 |
20110283145 | TECHNOLOGY INFRASTRUCTURE-CHANGE RISK MODEL - Apparatus and methods for reducing infrastructure failure rates. The apparatus and methods may compile and store data related to the physical devices and applications associated with an infrastructure change. Variables may be derived from the stored data using a range of methods and multiple variable values may be consolidated. A model may be developed based on the values and relationships of the derived variables. The model may be applied to assess the risk of a prospective infrastructure change. | 11-17-2011 |
20110283146 | RISK ELEMENT CONSOLIDATION - Apparatus and methods for reducing infrastructure failure rates. The apparatus and methods may involve reduction of data complexity. The reduction may be based on the use of nonlinear analysis to derive representative variables, which may be multi-valued. Multi-valued variables may be consolidated. A model may be developed based on the values and relationships of the derived variables. The model may be applied to assess the risk involved in a prospective infrastructure change. | 11-17-2011 |
John A. Cowan, Rome, GA US
Patent application number | Description | Published |
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20120041494 | VERTEBRAL IMPLANT - An implant and method for attaching to vertebral members with the implant including a plate and a cage. The plate is configured to be positioned against and anchored to the bodies of the vertebral members. The plate may also extend into the intervertebral space between the vertebral members. The cage extends outward from the plate and is positioned within the intervertebral space. The implant provides a low profile that is positionable between the bodies of the vertebral members and the lamina/pars/facet joint. The implant may be implanted utilizing a lateral access to the spine. The implant and method may further include just the plate without the cage. | 02-16-2012 |
20120226319 | INTERBODY DEVICE AND PLATE FOR SPINAL STABILIZATION AND INSTRUMENTS FOR POSITIONING SAME - Systems, methods and devices for providing stabilization between first and second vertebrae are provided. More particularly, in one form a system includes an implant configured to be positioned in a disc space between the first and second vertebrae and a freestanding plate for engagement with extradiscal surfaces of the first and second vertebrae. The system also includes an insertion instrument with an engaging portion configured to releasably engage with the implant and the plate such that the implant and plate can be positioned together relative to the first and second vertebrae. In one aspect, an angular orientation of the implant relative to the plate is adjustable when the implant and the plate are engaged by the instrument. In this or another aspect, the implant and plate are held in a contiguous relationship when engaged by the instrument. However, different forms and applications are also envisioned. | 09-06-2012 |
20120330418 | METHOD AND IMPLANT DEVICE FOR GRAFTING ADJACENT VERTEBRAL BODIES - A methodology for grafting together adjacent bony structures is provided using an implant device having an endplate with an inner disc portion and outer ring portion spaced from the inner disc portion by a connecting wall disposed therebetween. An endplate interior surface includes a retaining structure for securing the endplate to one of the bony structures, and endplate an exterior surface has an integrally formed socket. A ball-joint rod has a longitudinally extending body and an end, and at least a portion of the ball-joint rod end is curvilinear in shape. The curvilinear ball-joint rod end is rotatably disposed in the endplate socket to fixedly interconnect the bony structures. | 12-27-2012 |
20130231749 | INTERBODY DEVICE AND PLATE FOR SPINAL STABILIZATION AND INSTRUMENTS FOR POSITIONING SAME - Systems, methods and devices for providing stabilization between first and second vertebrae are provided. More particularly, in one form a system includes an implant configured to be positioned in a disc space between the first and second vertebrae and a freestanding plate for engagement with extradiscal surfaces of the first and second vertebrae. The system also includes an insertion instrument with an engaging portion configured to releasably engage with the implant and the plate such that the implant and plate can be positioned together relative to the first and second vertebrae. In one aspect, an angular orientation of the implant relative to the plate is adjustable when the implant and the plate are engaged by the instrument. In this or another aspect, the implant and plate are held in a contiguous relationship when engaged by the instrument. However, different forms and applications are also envisioned. | 09-05-2013 |
20130297027 | METHOD AND IMPLANT DEVICE FOR GRAFTING ADJACENT VERTEBRAL BODIES - A methodology for grafting together adjacent bony structures is provided using an implant device having an endplate with an inner disc portion and outer ring portion spaced from the inner disc portion by a connecting wall disposed there between. An endplate interior surface includes a retaining structure for securing the endplate to one of the bony structures, and endplate an exterior surface has an integrally formed socket. A ball-joint rod has a longitudinally extending body and an end, and at least a portion of the ball-joint rod end is curvilinear in shape. The curvilinear ball-joint rod end is rotatably disposed in the endplate socket to fixedly interconnect the bony structures. | 11-07-2013 |
20130317614 | METHOD AND IMPLANT DEVICE FOR GRAFTING ADJACENT VERTEBRAL BODIES - A methodology for grafting together adjacent bony structures is provided using an implant device having an endplate with an inner disc portion and outer ring portion spaced from the inner disc portion by a connecting wall disposed therebetween. An endplate interior surface includes a retaining structure for securing the endplate to one of the bony structures, and endplate an exterior surface has an integrally formed socket. A ball-joint rod has a longitudinally extending body and an end, and at least a portion of the ball-joint rod end is curvilinear in shape. The curvilinear ball-joint rod end is rotatably disposed in the endplate socket to fixedly interconnect the bony structures. | 11-28-2013 |
20140156009 | INTERBODY DEVICE AND PLATE FOR SPINAL STABILIZATION AND INSTRUMENTS FOR POSITIONING SAME - Systems, methods and devices for providing stabilization between first and second vertebrae are provided. More particularly, in one form a system includes an implant configured to be positioned in a disc space between the first and second vertebrae and a freestanding plate for engagement with extradiscal surfaces of the first and second vertebrae. The system also includes an insertion instrument with an engaging portion configured to releasably engage with the implant and the plate such that the implant and plate can be positioned together relative to the first and second vertebrae. In one aspect, an angular orientation of the implant relative to the plate is adjustable when the implant and the plate are engaged by the instrument. In this or another aspect, the implant and plate are held in a contiguous relationship when engaged by the instrument. However, different forms and applications are also envisioned. | 06-05-2014 |
John Steven Cowan, Winston-Salem, NC US
Patent application number | Description | Published |
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20120094509 | CONNECTOR SYSTEM AND ASSEMBLY HAVING INTEGRATED PROTECTION CIRCUITRY - A system configured to protect a load within a vehicle includes a plug subassembly and a sensor connector subassembly. The sensor connector subassembly is selectively connectable to the plug subassembly. A circuit board is secured within the sensor connector subassembly. The circuit board includes at least one positive temperature coefficient (PTC) device electrically connected between an activation switch and a load. The circuit board includes at least one circuit to protect against over-voltage or over-current to the load, detect a fault condition of the load, and determine whether the plug subassembly is connected to the sensor connector subassembly. | 04-19-2012 |
20130015929 | INTELLIGENT SWITCH SYSTEM AND ASSEMBLY HAVING INTEGRATED PROTECTION CIRCUITRY - A switch system includes a brake pedal having a ferromagnetic target, a main housing that securely retains a brake circuit board and a magnet, a sensor connector subassembly, and a plug connector subassembly. The system also includes a connector circuit board secured within the sensor connector subassembly and in communication with the brake circuit board. The connector circuit board includes at least one positive temperature coefficient (PTC) device electrically connected between the brake circuit board and at least one brake lamp. The connector circuit board may also include at least one circuit to protect against over-voltage or over-current to the at least one brake lamp, detect a fault condition, and determine whether the plug connector subassembly is connected to the sensor connector subassembly. | 01-17-2013 |
Josh Cowan, Canton, OH US
Patent application number | Description | Published |
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20080218014 | Friction Drive Spindle Unit - A spindle unit (A) for effecting a manufacturing or repair procedure includes a spindle assembly ( | 09-11-2008 |
Ken Cowan, Kirkland, WA US
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20090048646 | ON-DEMAND RETRANSMISSION OF DATA WITH AN IMPLANTABLE MEDICAL DEVICE - This document discloses, among other things, a telemetry system for requesting and receiving redundant data. A synchronization frame transmitted by an external device includes an echo code. The implantable device responds to the synchronization frame by sending real time data and echo data selected as a function of the echo code. | 02-19-2009 |
Kenneth F. Cowan, Kirkland, WA US
Patent application number | Description | Published |
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20080228237 | IMPLANTABLE MEDICAL DEVICE TELEMETRY WITH HOP-ON-ERROR FREQUENCY HOPPING - A telemetry system for data transmission between an implantable medical device and an external system includes a plurality of channels each representing a frequency band within a predetermined frequency range. The data transmission is performed using at least one active channel at any instant. Channel hopping is performed upon detecting an interruption of communication, such that a scan is performed through an array of channels selected from the plurality of channels. If a data frame is not successfully transmitted, it is repeatedly re-transmitted using the current and/or the next active channels until its transmission becomes successful. | 09-18-2008 |
20120065697 | IMPLANTABLE MEDICAL DEVICE TELEMETRY WITH HOP-ON-ERROR FREQUENCY HOPPING - A telemetry system for data transmission between an implantable medical device and an external system includes a plurality of channels each representing a frequency band within a predetermined frequency range. The data transmission is performed using at least one active channel at any instant. Channel hopping is performed upon detecting an interruption of communication, such that a scan is performed through an array of channels selected from the plurality of channels. If a data frame is not successfully transmitted, it is repeatedly re-transmitted using the current and/or the next active channels until its transmission becomes successful. | 03-15-2012 |
Kenneth Michael Cowan, Sugar Land, TX US
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20100096133 | METHOD FOR SEALING PIPE IN A WELL - A method for improving bonding and sealing in a well, comprising providing a wellbore, providing a pipe, coating an outside surface of the pipe with an adhesive thermoplastic resin, running the coated pipe into the wellbore, and causing the temperature of said wellbore to increase to a temperature greater than a melting temperature of said adhesive thermoplastic resin. | 04-22-2010 |
Leroy Frank Cowan, Highland, UT US
Patent application number | Description | Published |
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20080230132 | Fluid and gas distribution manifolds to which connectors and valves bodies are joined with brazed, silver-soldered or chemically-bonded connections - The present invention provides several embodiments of manifolds and distribution assemblies, having a manifold main body or multiple interconnecting tubular members and multiple connectors and/or valves which are unitary with the main body or tubular members. Some of the manifolds have four connectors in a common plane at right-angle intervals. For metal manifold assemblies, required pipe fittings and ball valves are welded, brazed or silver-soldered directly to the main body of the manifold. For polymeric plastic assemblies, chemical bonding of components is utilized. A distribution assembly made of metal or polymeric plastic, and having valves and connectors that are unitary is also disclosed. Intersecting tubular members can be cast or injection molded. | 09-25-2008 |
Lindsay Cowan, Rock Springs, WY US
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20120182207 | HIGH RESOLUTION SCINTILLATING DISPLAY AND METHOD OF USE - The present invention relates generally to a high resolution scintillating display. More specifically, this disclosure relates to a display comprised of a support frame matrix configured to secure a plurality of free moving display elements. Each display element is precisely positioned on the supporting frame matrix and having one or more image elements of the overall display printed thereon. The desired high resolution image is created after each individual display element is in place. | 07-19-2012 |
Martin E. Cowan, Moore, SC US
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20080241459 | Needled woven and nonwoven layers - A material having a woven layer and a nonwoven layer needled together. The woven layer contains a plurality of interwoven polypropylene tape elements and the nonwoven layer contains a plurality of intermingled polyester fiber elements. | 10-02-2008 |
20090081406 | Textile products and methods - Constructions for surface coverings such as wall coverings or floor coverings are provided. Components for surface coverings, precursors, materials, and the like are also provided. In one embodiment, a pile fabric suitable for use as a primary carpet fabric within a carpet construction or composite such as a cushioned carpet or tile includes a plurality of pile-forming yarns tufted through or adhered to a primary backing of integral dimensionally stable character. A cushioning layer of foam, felt, fabric, or other suitable cushioning material may be disposed at a position below the primary carpet fabric. | 03-26-2009 |
20100030171 | COMPOSITE ARTICLE SUITABLE FOR USE AS A WOUND DRESSING - A composite article comprises a fluid transport layer, a fluid retentive layer, and, optionally, a moisture vapor permeable film. The first surface of the fluid transport layer provides a fluid contacting surface. The fluid retentive layer is positioned so that the first surface layer of the fluid retentive layer is adjacent to the second surface of the fluid transport layer. The moisture vapor permeable film is positioned so that it is adjacent to the second surface of the fluid retentive layer. The composite article is suitable for use as a wound dressing. | 02-04-2010 |
20100030178 | COMPOSITE ARTICLE SUITABLE FOR USE AS A WOUND DRESSING - A composite article comprises a fluid transport layer having first and second surfaces and a hydrophobic layer applied to the first surface of the fluid transport layer. When the composite article is used as a wound dressing, the first surface of the fluid transport layer provides a skin-facing surface. The hydrophobic layer comprises a plurality of discontinuities, and at least a portion of the discontinuities have a dimension sufficient to permit the passage of fluid through the hydrophobic layer and into the fluid transport layer. | 02-04-2010 |
20110040289 | Wound Care Device Having Fluid Transfer Properties - This disclosure relates to wound care devices which are capable of one-way, directional flow of fluids and contaminants away from the wound site to the opposite side of the wound care device, which functions as a fluid reservoir. This fluid transport mechanism generally aids in reducing wound maceration by removing excess fluid, and potentially even bacteria, and is carried out without loss of physical integrity of the wound care device itself. In addition to providing a uni-directional fluid transport mechanism, the wound care device may contain a topically applied silver-based antimicrobial finish which provides certain levels of antimicrobial agent to the wound in order to clear infection from the wound site and control bacterial growth in the wound care dressing. Exemplary topical antimicrobial finishes include silver ion-releasing compounds. | 02-17-2011 |
20110280928 | Wound Care Device Having Fluid Transfer Properties - This disclosure relates to wound care devices which are capable of one-way, directional flow of fluids and contaminants away from the wound site to the opposite side of the wound care device, which functions as a fluid reservoir. This fluid transport mechanism generally aids in reducing wound maceration by removing excess fluid, and potentially even bacteria, and is carried out without loss of physical integrity of the wound care device itself. In addition to providing a uni-directional fluid transport mechanism, the wound care device may contain a topically applied silver-based antimicrobial finish which provides certain levels of antimicrobial agent to the wound in order to clear infection from the wound site and control bacterial growth in the wound care dressing. Exemplary topical antimicrobial finishes include silver ion-releasing compounds. | 11-17-2011 |
Michael A. Cowan, Charlotte, NC US
Patent application number | Description | Published |
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20100049252 | Transverse Connector Device for Extending an Existing Spinal Fixation System - An extension rod device is provided for extending an existing spinal fixation system. The device can engage with implanted spinal fixation elements and house extension spinal rods that expand the fixation system to adjacent vertebrae. According to various embodiments, an extension rod device may include one or more extension spinal rods attachable to a transverse connector that is secured between an existing, implanted spinal fixation system. The extension rod device may attach to an existing transverse connector, already implanted with the existing spinal fixation system, or the extension rod device may include a new transverse connector, also for securing to the existing spinal fixation system. | 02-25-2010 |
20110224731 | Interspinous Process Spacing Device - Various embodiments described herein provide devices and associated methods for treating spinal disease by implanting one or more interspinous process spacing devices. In one embodiment, an interspinous process spacing device includes a first attachment side and a second attachment side, whereby each attachment side includes one or more slots formed in the outer surface and oriented proximate one end for receiving fasteners extending inwardly from a second interspinous process spacing device. The device further includes a spacer tray positioned between the first attachment side and the second attachment side, the spacer tray extending from the first attachment side and slideably insertable through a tray slot formed in the second attachment side, wherein the spacer tray is adapted to retain adjacent spinous processes in a spaced apart orientation. The device further includes securing means for securing the second attachment side relative to the first attachment side, wherein, upon securing the second attachment side relative to the first attachment side, the interspinous process spacing device is engaged with the adjacent spinous processes. | 09-15-2011 |
20110224740 | Implantation Tools for Interspinous Process Spacing Device - Various embodiments described herein provide devices and associated methods for treating spinal disease by implanting one or more interspinous process spacing devices. In one embodiment, an interspinous process spacing device includes a first attachment side and a second attachment side, whereby each attachment side includes one or more slots formed in the outer surface and oriented proximate one end for receiving fasteners extending inwardly from a second interspinous process spacing device. The device further includes a spacer tray positioned between the first attachment side and the second attachment side, the spacer tray extending from the first attachment side and slideably insertable through a tray slot formed in the second attachment side, wherein the spacer tray is adapted to retain adjacent spinous processes in a spaced apart orientation. The device further includes securing means for securing the second attachment side relative to the first attachment side, wherein, upon securing the second attachment side relative to the first attachment side, the interspinous process spacing device is engaged with the adjacent spinous processes. | 09-15-2011 |
20120310292 | Implantation Tools for Interspinous Process Spacing Device - Various embodiments described herein provide surgical instrument tools, systems and associated methods for treating spinal disease by implanting one or more interspinous process spacing devices. The surgical instruments for implanting an interspinous process spacing device comprise first and second arms which engage opposite sides of an implant device, and have an element for positioning the arms in alignment for securing the implant onto spinal processes. | 12-06-2012 |
20140107703 | Interspinous Process Spacing Device - Various interspinous process spacing devices and associated methods are provided for treating spinal disease. In one embodiment, an interspinous process spacing device includes a first attachment side and a second attachment side, each attachment side including one or more slots formed therein and positioned proximate one end for receiving fasteners extending inwardly from a second interspinous process spacing device. The device further includes a spacer tray extending from the first attachment side and slideably insertable through a spacer tray slot formed in the second attachment side, wherein the spacer tray is adapted to retain adjacent spinous processes in a spaced apart orientation, and wherein at least a portion of the spacer tray has a longitudinally arcuate shape adapted to facilitate angled insertion of the spacer tray through the spacer tray slot. The device further includes securing means for securing the second attachment side relative to the first attachment side. | 04-17-2014 |
20140114366 | Implantation Tools for Interspinous Process Spacing Device - Various embodiments described herein provide interspinous process spacing devices and related systems and methods. In one embodiment, surgical instrument system for implanting an interspinous process spacing device includes a first arm having a proximal end, an elongated central portion, and a distal end, wherein the distal end includes a first engagement element configured for releasably engaging a first attachment side of an interspinous process spacing device. The system also includes a second arm having a proximal end, an elongated central portion, and a distal end, wherein the distal end includes a second engagement element configured for releasably engaging a second attachment side of the interspinous process spacing device. The first arm and the second arm are removably attachable to one another via attachment elements and are configured for aligning a spacer of the first attachment side and a spacer opening of the second attachment side. | 04-24-2014 |
Michael J. Cowan, Macomb, MI US
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20100119324 | Clinch Nut to Prevent Corrosion - A clinch nut is used to attach a first panel and a second panel with a space therebetween for accepting a liquid primer. The body has a nut face for abutting a first panel and a threaded aperture through the nut body for receiving a threaded bolt. The nut face has grooves into which the first panel is deformed to clinch the nut body to the first panel. An abutment rises from the nut face a distance greater than the thickness of the first panel so that upon the bolting of the second panel to the first panel by the insertion of the threaded bolt into the threaded aperture of the nut body, the second panel will be spaced from the first panel by the abutment thereby assuring that the liquid primer can flow between the first and second panels. | 05-13-2010 |
Mike D. Cowan, Odessa, TX US
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20090071720 | Mobile Land Drilling Rig and Method of Installation - A highly mobile and capable oil, gas and geothermal well drilling rig is shown which provides for the rapid placement, assembly, disassembly, and repositioning of various rig components of the drilling rig The drilling rig includes a support base and working floor which is trailerable and which can be rapidly erected to a working height at the well site. A special drawworks trailer both transports the drawworks and the rig derrick. Hydraulic cylinders on the drawworks trailer are used to move the derrick from a horizontal, transport position to a vertical, working position. At the same time, the weight of the derrick is off-loaded from the drawworks trailer to the base support structure. The selection and arrangement of the various rig components provides a faster set up and take down operation than was previously obtained. | 03-19-2009 |
Noah J. Cowan, Baltimore, MD US
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20090171271 | Active Cannula for Bio-Sensing and Surgical Intervention - Disclosed is a surgical needle, or active cannula, that is capable of following a complex path through cavities and tissue within a patient's anatomy. The needle has a plurality of overlapping flexible tubes, each of which has a pre-formed curvature and a pre-determined flexibility. Each of the plurality of flexible tubes is selected based on their respective pre-formed curvature and flexibility so that a given overlap configuration causes the combination of overlapping flexible tubes to form a predetermined shape that substantially matches a desired path through the anatomy. By individually controlling the translation and angular orientation of each of the flexible tubes, the surgical needle may be guided through the anatomy according to the desired path. | 07-02-2009 |
20130018303 | ACTIVE CANNULA FOR BIO-SENSING AND SURGICAL INTERVENTION - A method for guiding a surgical cannula having a plurality of overlapping flexible tubes includes determining a desired cannula path; selecting the plurality of flexible tubes, wherein each of the flexible tubes within the plurality has a pre-formed curvature and a flexibility; determining a final overlap configuration of the plurality of flexible tubes such that a resulting curvature of the overlap configuration substantially corresponds to the desired cannula path; and determining a plurality of intermediate overlap configurations of the plurality of flexible tubes. Each of the intermediate configurations correspond to the desired cannula path. | 01-17-2013 |
Patrick J. Cowan, Hockessin, DE US
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20110039309 | PROCESS FOR TREATING BIOMASS TO DERIVATIZE POLYSACCHARIDES CONTAINED THEREIN TO INCREASE THEIR ACCESSIBILITY TO HYDROLYSIS AND SUBSEQUENT FERMENTATION - A process is described for producing fermentable sugars derivable from biomass that contains polysaccharide, such as cellulose, made increasingly accessible as a substrate for enzymatic degradation or other methods of depolymerization. These fermentable sugars are subsequently able to be fermented to produce various target chemicals, such as alcohols, aldehydes, ketones or acids. | 02-17-2011 |
20110129880 | PROCESS FOR TREATING BIOMASS TO INCREASE ACCESSIBILITY OF POLYSACCARIDES CONTAINED THEREIN TO HYDROLYSIS AND SUBSEQUENT FERMENTATION, AND POLYSACCHARIDES WITH INCREASED ACCESSIBILITY - In this invention, a process for producing fermentable sugars derivable from biomass that contains polysaccharide, such as cellulose, which has been made increasingly accessible as a substrate for enzymatic degradation or other methods of depolymerization. The process of the present invention increases accessibility of polysaccharides, typically present in biomass and produces polysaccharides with increased accessibility. The polysaccharides with increased accessibility may be subsequently saccharified to yield fermentable sugars. These fermentable sugars are subsequently able to be fermented to produce various target chemicals, such as alcohols, aldehydes, ketones or acids. | 06-02-2011 |
20140127755 | PROCESS FOR TREATING BIOMASS TO DERIVATIZE POLYSACCHARIDES CONTAINED THEREIN TO INCREASE THEIR ACCESSIBILITY TO HYDROLYSIS AND SUBSEQUENT FERMENTATION - A process is described for producing fermentable sugars derivable from biomass that contains polysaccharide, such as cellulose, made increasingly accessible as a substrate for enzymatic degradation or other methods of depolymerization. These fermentable sugars are subsequently able to be fermented to produce various target chemicals, such as alcohols, aldehydes, ketones or acids. | 05-08-2014 |
Paul Cowan, Humble, TX US
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20100113005 | METHODS AND APPARATUS FOR MOBILE UNITS WITH LOCAL ACTION AND REMEDIATION - A remediation system employs local and autonomous conditions within the mobile unit itself. A method for performing remediation for a plurality of mobile units generally includes determining a first set of remediations, wherein each remediation includes a condition for determining whether a remediation is necessary for one of the mobile units, and an action for addressing the condition. The system may determine a second set of remediations, and providing the second set of remediations to the mobile units. | 05-06-2010 |
Paul Alexander Cowan, Humble, TX US
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20090096585 | Methods, Systems and Apparatus for Radio Frequency Identification (RFID) System Configuration Management - Methods, systems and apparatus for controlling initiation of configuration of RFID readers using initiate-staging control information, include interrogating a reading zone of a reader for initiate-staging control information, and selectively setting the reader in an initiate-staging state in accordance with initiate-staging control information detected by the interrogation. The interrogation may include interrogating at least one RFID tag located in the reading zone of the reader for initiate-staging control information stored therein. The interrogation may include interrogating a reading zone of the reader for initiate-staging control information only during a predetermined period of time T | 04-16-2009 |
Paul D. Cowan, Pinckney, MI US
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20140101977 | ULTRA-VIOLET SELECTIVE VEHICLE DECORATION - An apparatus and method for selectively decorating a vehicle surface are disclosed. The apparatus is a removable applique with a front face including a graphic comprising ultra-violet responsive material and a back face including an attachment agent having the ability to be applied and removed from the surface of the vehicle without causing damage. The method includes receiving the removable applique on the surface of a vehicle. The method further includes sending an instruction to illuminate an ultra-violet source to direct ultra-violet light at the graphic of the removable applique to render the graphic visible. In one embodiment, the instruction to illuminate the ultra-violet source can be sent in response to the activation of a switch, button, control panel or other input means of controlling the ultra-violet source. In another embodiment, the instruction to illuminate the ultra-violet source can be sent in response to a vehicle state. | 04-17-2014 |
Randy Cowan, New York, NY US
Patent application number | Description | Published |
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20110196839 | METHOD AND SYSTEM FOR PROCESSING RAW FINANCIAL DATA STREAMS TO PRODUCE AND DISTRIBUTE STRUCTURED AND VALIDATED PRODUCT OFFERING OBJECTS - A real time information manager which processes raw data from data providers, such as feeds of current information about financial product offerings, is provided. Raw data objects received from various data providers are analyzed, formatted, and a current version of each unique data object is stored in an object storage pool. Information about the state of each objects is transmitted on a particular output data channel in accordance with the type of object. A subscriber process can access one or more of the data channels and utilize the broadcast data. In one configuration, one or more client managers are provided which subscribe to particular data channels and serve as an intermediary between the real time information manager and sets of clients. | 08-11-2011 |
20110219099 | Method and System for Processing Raw Financial Data Streams to Produce and Distribute Structured and Validated Product Offering Data to Subscribing Clients - A method and system is disclosed for processing information provided from various content providers in the form objects having states subject to periodic updates. Formatted information indicating a current state of the objects are delivered to subscribing clients in substantially real-time. An information manager module is configured to receiving raw data objects from the content providers, format the information, and broadcast current state information on various broadcast data stream. A client manager module supports multiple client communication sessions and connects to at least one broadcast data stream. Current state information received on a broadcast data stream is processed and transmitted to specific clients in accordance with processing rules specified in the client profiles. | 09-08-2011 |
20120016968 | Method and System for Processing Raw Financial Data Streams to Produce and Distribute Structured and Validated Product Offering Data to Subscribing Clients - A method and system is disclosed for processing information provided from various content providers in the form objects having states subject to periodic updates. Formatted information indicating a current state of the objects are delivered to subscribing clients in substantially real-time. An information manager module is configured to receiving raw data objects from the content providers, format the information, and broadcast current state information on various broadcast data stream. A client manager module supports multiple client communication sessions and connects to at least one broadcast data stream. Current state information received on a broadcast data stream is processed and transmitted to specific clients in accordance with processing rules specified in the client profiles. | 01-19-2012 |
20140304284 | Method And System For Processing Raw Financial Data Streams To Produce And Distribute Structured And Validated Product Offering Objects - A real time information manager which processes raw data from data providers, such as feeds of current information about financial product offerings, is provided. Raw data objects received from various data providers are analyzed, formatted, and a current version of each unique data object is stored in an object storage pool. Information about the state of each objects is transmitted on a particular output data channel in accordance with the type of object. A subscriber process can access one or more of the data channels and utilize the broadcast data. In one configuration, one or more client managers are provided which subscribe to particular data channels and serve as an intermediary between the real time information manager and sets of clients. | 10-09-2014 |
Randy G. Cowan, Sioux Falls, SD US
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20100203279 | LABEL STRUCTURE INCORPORATING A LEAFLET FOR USE ON SMALL CONTAINERS - A label structure is disclosed for mounting on a container and includes a base panel for affixing to a surface of the container. An adhesive is applied to at least a portion of a rear face of the base panel for adhering the base panel to the container. The label structure further includes a leaflet associated with the base panel for application to the container with the base panel, and the leaflet comprising at least one panel with opposite faces. The label structure also includes a laminating strip securing the leaflet to the base panel, and the laminating strip overlies the leaflet and overlying the base panel. In some embodiments, the leaflet is positioned adjacent to the base panel, with a first portion of the leaflet overlying the base panel and a second portion of the leaflet not overlying the base panel. | 08-12-2010 |
Richard Grimes Cowan, Nashville, TN US
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20120143938 | METHODS AND APPARATUS FOR DYNAMIC ENDPOINT GENERATORS AND DYNAMIC REMOTE OBJECT DISCOVERY AND BROKERAGE - The system and method disclosed herein is a dynamic endpoint generator that enables a client device or application to consume business objects. The business objects are dynamic business objects whose definitions can be changed by either adding or removing data or actions without the need to involve technical or development resources to reconfigure or recompile the actual objects. The endpoint generator provides updated endpoint information automatically without the need for manual generation of endpoint or contract data. If a business object is modified or newly added, the endpoint generator is automatically notified and publishes information about the modified or newly added object. The client device that is accessing the business object is notified about the modified or newly added object. Or, an endpoint is generated when a client device requests a business object. | 06-07-2012 |
Rick Cowan, Oklahoma City, OK US
Robert M. Cowan, Dayton, NJ US
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20090202409 | Temperature controlled gas contactor device and method - This invention provides a method and process for the facile extraction of selected gases by means of a permeable membrane module, also known as a permeator, with effective and beneficial control of temperature the apparatus allowing temperature gradients or isothermal operation. | 08-13-2009 |
20100300894 | CARBON DIOXIDE CAPTURE USING RESIN-WAFER ELECTRODEIONIZATION - The present invention provides a resin-wafer electrodeionization (RW-EDI) apparatus including cathode and anode electrodes separated by a plurality of porous solid ion exchange resin wafers, which when in use are filled with an aqueous fluid. The apparatus includes one or more wafers comprising a basic ion exchange medium, and preferably includes one or more wafers comprising an acidic ion exchange medium. The wafers are separated from one another by ion exchange membranes. The fluid within the acidic and/or basic ion exchange wafers preferably includes, or is in contact with, a carbonic anhydrase (CA) enzyme to facilitate conversion of bicarbonate ion to carbon dioxide within the acidic medium. A pH suitable for exchange of CO | 12-02-2010 |
20130292248 | CARBON DIOXIDE CAPTURE USING RESIN-WAFER ELECTRODEIONIZATION - The present invention provides a resin-wafer electrodeionization (RW-EDI) apparatus including cathode and anode electrodes separated by a plurality of porous solid ion exchange resin wafers, which when in use are filled with an aqueous fluid. The apparatus includes one or more wafers comprising a basic ion exchange medium, and preferably includes one or more wafers comprising an acidic ion exchange medium. The wafers are separated from one another by ion exchange membranes. The fluid within the acidic and/or basic ion exchange wafers preferably includes, or is in contact with, a carbonic anhydrase (CA) enzyme to facilitate conversion of bicarbonate ion to carbon dioxide within the acidic medium. A pH suitable for exchange of CO | 11-07-2013 |
20150021184 | Carbon Dioxide Capture Using Resin-Wafer Electrodeionization - The present invention provides a resin-wafer electrodeionization (RW-EDI) apparatus including cathode and anode electrodes separated by a plurality of porous solid ion exchange resin wafers, which when in use are filled with an aqueous fluid. The apparatus includes one or more wafers comprising a basic ion exchange medium, and preferably includes one or more wafers comprising an acidic ion exchange medium. The wafers are separated from one another by ion exchange membranes. The fluid within the acidic and/or basic ion exchange wafers preferably includes, or is in contact with, a carbonic anhydrase (CA) enzyme to facilitate conversion of bicarbonate ion to carbon dioxide within the acidic medium. A pH suitable for exchange of CO | 01-22-2015 |
Robert S. Cowan, Matthews, NC US
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20100071684 | SOLAR PANEL ADJUSTMENT MECHANISM - The present invention provides methods and systems for a solar panel adjustment device, including a solar panel having a first end and a second end for receiving sunlight, a first pivot frame engaged to the first end of the solar panel for adjusting the solar panel, a second pivot frame engaged to the second end of the solar panel for adjusting the solar panel, and at least one drive means for adjusting the first pivot frame and the second pivot frame independently of one another | 03-25-2010 |
Ron Cowan, Rochester Hills, MI US
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20120034115 | METHOD OF OPERATING A PUMP/MOTOR - A method of operating a pump/motor includes pumping working fluid into a high-pressure manifold with a first piston/cylinder assembly while the piston in the first piston/cylinder assembly is displaced from a bottom dead center position to a top dead center position, and transferring working fluid from the high-pressure manifold to the cylinder of a second piston/cylinder assembly to displace the piston of the second piston/cylinder assembly from a top dead center position to a bottom dead center position, thereby imparting torque on a cam and an output shaft, within the same complete revolution of the cam and the output shaft in which working fluid is pumped into the high-pressure manifold by the first piston/cylinder assembly. | 02-09-2012 |
Sabrea Laree Cowan, Dayton, OH US
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20110101062 | POUCH AND POUCHES TO CARRY PERSONAL ITEMS AND LIGHTS ON A BELT - A pouch to carry personal items and lights on a belt includes: a sheet having a first surface, a second surface, and a side; a container on the first surface, adapted to retain the personal item; a first lighting element on the second surface, directed generally away from the sheet; a second lighting element on the second surface, directed generally toward the side; and a lateral aperture in the sheet adapted to retain the device on the belt, thereby carrying the personal items. | 05-05-2011 |
Samuel Mark Cowan, Rock Springs, WY US
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20120182207 | HIGH RESOLUTION SCINTILLATING DISPLAY AND METHOD OF USE - The present invention relates generally to a high resolution scintillating display. More specifically, this disclosure relates to a display comprised of a support frame matrix configured to secure a plurality of free moving display elements. Each display element is precisely positioned on the supporting frame matrix and having one or more image elements of the overall display printed thereon. The desired high resolution image is created after each individual display element is in place. | 07-19-2012 |
Sandra S. Cowan, Yukon, OK US
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20090325829 | Reduced Molybdenum Grease Formulation - Extreme pressure additives may be added to greases to improve their lubricating properties, particularly to decrease friction and wear of parts that are exposed to very high pressures. Molybdenum disulfide is frequently used as an extreme pressure additive. However, molybdenum disulfide is expensive, has limited availability, and may have adverse environmental effects. This invention discloses an extreme pressure additive and grease formulation where the amount of molybdenum disulfide is reduced through the addition of calcium carbonate while the performance characteristics of the grease are maintained or improved. The extreme pressure additive may comprise about 20% molybdenum sulfide and about 80% calcium carbonate, by weight. | 12-31-2009 |
20110065615 | REDUCED MOLYBDENUM GREASE FORMULATION - Extreme pressure additives may be added to greases to improve their lubricating properties, particularly to decrease friction and wear of parts that are exposed to very high pressures. Molybdenum disulfide is frequently used as an extreme pressure additive. However, molybdenum disulfide is expensive, has limited availability, and may have adverse environmental effects. This invention discloses an extreme pressure additive and grease formulation where the amount of molybdenum disulfide is reduced through the addition of calcium carbonate while the performance characteristics of the grease are maintained or improved. The extreme pressure additive may comprise about 20% molybdenum sulfide and about 80% calcium carbonate, by weight. | 03-17-2011 |
Siu Man L. Cowan, Lewis Center, OH US
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20100239676 | Stable Aerosolizable Suspensions of Proteins in Ethanol - Stable suspensions of a biologically active protein are disclosed that are suited for aerosol delivery to the lungs of a patient in need of treatment, which comprise particles of biologically active protein suspended in ethanol. In a preferred embodiment, the invention describes a stable suspension of insulin useful for aerosol delivery to the lungs of a patient in need of treatment comprising particles of a pharmaceutically effective amount of insulin suspended in ethanol. A method of delivering a therapeutically effective amount of a protein to the respiratory tract of a patient is described which comprises producing an aerosol of a stable liquid suspension of a protein using an electrohydrodynamic spraying means wherein the liquid suspension comprises particles of the protein suspended in ethanol. The stable ethanol suspensions of the invention may optionally contain up to about 20% (V/V) of a pharmaceutically acceptable formulation additive such as glycerol, propylene glycol and polyethylene glycol as well as minor amounts (from about 0.05% to about 5.0% W/V) of a pharmaceutically acceptable excipient. | 09-23-2010 |
Timothy M. Cowan, Sudbury, MA US
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20120031811 | SELECTIVE HYDROCRACKING PROCESS FOR EITHER NAPHTHA OR DISTILLATE PRODUCTION - A hydrocracking zone for the selective production of either a naphtha product stream or a middle distillate stream from a hydrocarbonaceous feedstock utilizing a fixed catalyst and varying the ammonia concentration level introduced to the hydrocracking zone. The ammonia can be obtained by the reaction of nitrogen in the hydrocarbonaceous feedstock in a hydrotreating reactor, or from an external ammonia source, where the ammonia concentration is controlled by a stripping zone which allows an ammonia concentration in the range of about 0 to about 50 wppm to be introduced into the hydrocracking zone to yield a naphtha stream and an ammonia concentration in the range of about 20 to about 200 wppm to be introduced into the hydrocracking zone to yield a middle distillate stream. | 02-09-2012 |