Spohn
Brian Spohn, Suwanee, GA US
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20150347157 | OPERATING SYSTEM (OS) INDEPENDENT DEVICE DRIVERS - A device driver is configured to provide access to at least one peripheral device through a normalized interface. A loader is provided with the device driver. When the loader is executed, the loader loads the device driver to an operating system (OS) within its own independent processing context. The interactions through the normalized interface are OS independent. | 12-03-2015 |
Gunther Spohn, Zurich CH
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20110027220 | Interleukin-1 Conjugates and Uses Thereof - The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen array, wherein the antigen is an IL-1 protein, an IL-1 mutein or an IL-1 fragment. More specifically, the invention provides a composition comprising a virus-like particle, and at least one IL-1 protein, IL-1 mutein or at least one IL-1 fragment linked thereto. The invention also provides a process for producing the composition. The compositions of the invention are useful in the production of vaccines for the treatment of inflammatory diseases, and chronic autoimmune diseases, genetic diseases and cardiovascular diseases. The composition of the invention efficiently induces immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context. | 02-03-2011 |
20110091411 | Interleukin-1 Muteins Linked to Virus-Like Particles to Treat IL-1 Associated Diseases - The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen array, wherein the antigen is an IL-1 mutein. More specifically, the invention provides a composition comprising a virus-like particle, and at least one IL-1 mutein linked thereto. The invention also provides a process for producing the composition. The compositions of the invention are useful in the production of vaccines for the treatment of inflammatory diseases, and chronic autoimmune diseases, genetic diseases and cardiovascular diseases. The composition of the invention efficiently induces immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context. | 04-21-2011 |
20110318300 | User of Interleukin-1 Conjugates in the Treatment of Diabetes - The invention provides compositions, pharmaceutical compositions and vaccines for the treatment, amelioration and/or prophylaxis of diabetes, preferably of type II diabetes. The compositions, pharmaceutical compositions and vaccines of the invention comprise a core particle and an antigen, wherein said antigen comprises an interleukin-1 (IL-1) molecule. When administered to an animal, preferably to a human, said compositions, pharmaceutical compositions, and vaccines induce efficient immune responses, in particular antibody responses, wherein typically and preferably said antibody responses are directed against IL-1. Thus, the invention provides methods of treating, ameliorating or preventing diabetes, preferably type II diabetes, by way of active immunization against IL-1. | 12-29-2011 |
20130115189 | Use of Interleukin-1 Beta Mutein Conjugates in the Treatment of Diabetes - The present invention provides compositions, pharmaceutical compositions and vaccines for the treatment, amelioration and/or prophylaxis of type II diabetes. The compositions, pharmaceutical compositions and vaccines of the invention comprise a virus-like particle of an RNA bacteriophage and an antigen, wherein said antigen comprises an interleukin-1 beta (IL-1β) mutein. When administered to an animal, preferably to a human, said compositions, pharmaceutical compositions, and vaccines induce efficient immune responses, in particular antibody responses, wherein typically and preferably said antibody responses are directed against IL-1β. Thus, the invention provides methods of treating, ameliorating or preventing type II diabetes by way of active immunization against IL-1β. | 05-09-2013 |
Gunther Spohn, Zurich DE
Patent application number | Description | Published |
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20130230484 | Interleukin-1 Conjugates and Uses Thereof - The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen array, wherein the antigen is an IL-1 protein, an IL-1 mutein or an IL-1 fragment. More specifically, the invention provides a composition comprising a virus-like particle, and at least one IL-1 protein, IL-1 mutein or at least one IL-1 fragment linked thereto. The invention also provides a process for producing the composition. The compositions of the invention are useful in the production of vaccines for the treatment of inflammatory diseases, and chronic autoimmune diseases, genetic diseases and cardiovascular diseases. The composition of the invention efficiently induces immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context. | 09-05-2013 |
Markus Spohn, Foster City, CA US
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20110302135 | MAINTAINING APPLICATIONS THAT ARE OCCASIONALLY CONNECTED TO AN ONLINE SERVICES SYSTEM - In a method for maintaining applications that are occasionally connected to an online services system, metadata describing at least a portion of an online services database is retrieved and the portion of the online services database is authorized for replication at a software application, information for an entity for an application database in accordance with metadata is determined, information is sent for the entity to an application data management service, data for the software application is retrieved from the online services database in accordance with metadata, at least a portion of the data for the software application is sent to the application data management service and the portion of the data for the software application should be synchronized with the online services database, a request for information is received for rendering a component of a user interface, and information is provided for rendering the component of the user interface for the software application | 12-08-2011 |
20130191361 | OPTIMIZING LOCATION AND MOBILE SEARCH - A method of optimizing digital content for searches performed on mobile devices. The method may include receiving digital content that includes one or more pages and analyzing the digital content to determine one or more properties of the digital content that relate to placement of a reference to the digital content in mobile search results. The method may also include analyzing the properties of the digital content to determine one or more optimizations to apply to the digital content to improve the placement of the reference to the digital content in the mobile search results. In addition, the method may include generating one or more recommendations for adapting the digital content based on the optimizations. | 07-25-2013 |
Markus Spohn, Oberreichenbach DE
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20090095495 | ROTATING AGRICULTURAL TOOL WITH BEARING ARRANGEMENT - The invention relates to a rotating, disc-shaped, agricultural tool which is mounted in a frame of a machine via a hub and a bearing arrangement. The bearing arrangement is distinguished by the fact that it is formed from two angular roller bearings which are set in back-to-back arrangement and whose raceways are arranged inclined at an angle to a bearing axis, wherein a space accommodation the angular roller bearings is defined on the outside in the radial direction by a hub body, of V-shaped design in its centre part and having contact surfaces, and on the inside in the radial direction by a supporting ring having spaced-apart contact surfaces on both sides in the axial direction, wherein the hub body is provided at an axial end with a fastening element for fastening the tool. In this way, a captive bearing unit is provided which is already provided with the appropriate prestress and which only needs to be connected to the agricultural tool and to the frame by the end user, i.e. by the manufacturer of an agricultural machine. | 04-16-2009 |
Michael Spohn, Butler, PA US
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20100204573 | FLUID PATH SET PROVIDING GRAVITY FLOW PREVENTION - A fluid path set for delivery of an injection fluid includes a flexible tube. The flexible tube has a first end and a second end and a length defined between the first and second ends when the flexible tube is straightened. The flexible tube has a longitudinal axis extending along the length of the flexible tube. The flexible tube defines a transverse formation extending generally perpendicular to the longitudinal axis of the flexible tube. The fluid path set further includes a clip mechanism for maintaining the transverse formation in the flexible tube such fluid contained within the flexible tube at one end portion cannot flow through the length of the flexible tube to displace a less dense fluid contained within the flexible tube at the other end portion thereof by means of gravitational flow. | 08-12-2010 |
20120123257 | Multi-Fluid Medical Injector System and Methods of Operation - A multi-fluid injector system and methods of operation thereof are presented. One embodiment of such a fluid injector system includes a powered injector, a pressure jacket support, a syringe pressure jacket, and a syringe. The pressure jacket support includes a front plate and a rear plate. The rear plate is connected to the injector and the front plate is spaced from the rear plate and defines a slot. The syringe pressure jacket has a proximal end pivotally connected to the rear plate so that a distal end of the pressure jacket pivots relative to the front plate. The syringe has a syringe body with a distally extending discharge conduit. With the syringe disposed in a barrel of the pressure jacket, pivotal movement of the pressure jacket results in the distal end thereof pivoting toward the front plate to place the discharge conduit within the slot in the front plate. | 05-17-2012 |
Michael A. Spohn, Fenelton, PA US
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20130255390 | HIGH PRESSURE SENSOR FOR USE WITH A FLUID DELIVERY SYSTEM - A pressure sensor for use with a fluid delivery system having good sensitivity at low pressure, but also configured to remain in operating condition after being exposed to high pressures is disclosed herein. In one variation, the pressure sensor includes a fluid path set, a deformable element associated with the fluid path set and configured to deform in response to an external pressure, and a pressure transducer for monitoring deformation of the deformable element. In certain embodiments, the pressure sensor is configured to measure fluid pressure within the range of between about 0 mm Hg to about 300 mm Hg. However, the sensor pressure is also be configured to remain functional after being exposed to pressure in excess of about 60,000 mm Hg. | 10-03-2013 |
20140088494 | FLUID INJECTION SYSTEM HAVING VARIOUS SYSTEMS FOR CONTROLLING AN INJECTION PROCEDURE - A fluid injection system that includes an injector head having a syringe for delivering a fluid to a patient; a mounting structure pivotally connected to the injector head and configured to support the injector head above a surface; and a control system operationally coupled to the injector head for controlling an injection procedure is disclosed. The fluid injection system is provided with various sensors to control various aspects of the fluid injection system, such as the establishment of a reference plane, the determination of a tilt angle of the injector head, and the determination of a temperature of an actuation system of the injector head. | 03-27-2014 |
20140107480 | Fluid Delivery System with High and Low Pressure Hand Manifold - A fluid delivery system is provided and includes a power injector supporting a high pressure syringe. The fluid delivery system further includes a manifold and a low pressure hand-operated syringe. The manifold generally includes a plurality of fluid control valves in series fluid communication. A first fluid control valve of the plurality of fluid control valves has a first port, a second inlet port, and a third port. The third port of the first fluid control valve is in fluid connection with a first port of a second fluid control valve. The low pressure hand-operated syringe is in fluid connection with the first port of the first fluid control valve, and the high pressure syringe is in fluid connection with the second port of the first fluid control valve. The fluid control valves may be multi-position stopcock valves. | 04-17-2014 |
20140261713 | Fluid Path Set with Turbulent Mixing Chamber, Backflow Compensator - A fluid path set includes a first fluid line having a proximal end fluidly connectable to a source of a first fluid and a second fluid line having a proximal end fluidly connectable to a source of a second fluid. A flow mixing device is in fluid communication with distal ends of the first and second fluid lines. The flow mixing device includes a housing, a first fluid port provided for receiving the first fluid, and a second fluid port for receiving the second fluid. A mixing chamber is disposed within the housing and is in fluid communication with the first and second fluid ports. A third fluid port in fluid communication with the mixing chamber for discharging a mixed solution of the first and second fluids. A turbulent flow inducing member is disposed within the mixing chamber for promoting turbulent mixing of the first and second fluids. | 09-18-2014 |
20140350521 | Connector And Fluid Path Set For A Fluid Delivery System - The fluid injector system includes a source of injection fluid, a pump device, a fluid control device operably associated with the pump device, and a fluid path set in fluid connection with the source of injection fluid and the pump device. The fluid path set includes a multi-patient fluid path section adapted for fluid connection to at least one pressurizing device, a per-patient fluid path section adapted for fluid connection with a patient and comprising at least one check valve, and a connector for removably and fluidly connecting the multi-patient fluid path section with the per-patient fluid path section. | 11-27-2014 |
20150202426 | Fluid Delivery System, Fluid Path Set, and Pressure Isolation Mechanism with Hemodynamic Pressure Dampening Correction - The fluid delivery system includes a pressure isolation mechanism including a first lumen associated with the pressurizing device, a second lumen associated with the low pressure fluid delivery system, and a pressure isolation port, a first valve having a normally open position permitting fluid communication between the first lumen and the second lumen and movable to a closed position when fluid pressure in the first lumen reaches a predetermined pressure level, the first valve isolating the pressure isolation port from the first lumen in the closed position, and a second valve associated with the second lumen and regulating fluid flow through the second lumen, wherein the second valve substantially isolates the low pressure fluid delivery system from hemodynamic blood pressure signals. A method for correcting for dampened hemodynamic blood pressure signals in a fluid delivery system is also described. | 07-23-2015 |
Michael Lee Spohn, Waukesha, WI US
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20140064454 | X-RAY SYSTEM AND METHOD WITH DIGITAL IMAGE ACQUISITION USING A PHOTOVOLTAIC DEVICE - An X-ray imaging system is provided. The X-ray imaging system includes an X-ray radiation source. The X-ray imaging system also includes a source controller coupled to the source and configured to command emission of X-rays for image exposures. The X-ray imaging system further includes a digital X-ray detector configured to acquire X-ray image data without communication from the source controller, wherein the digital X-ray detector includes a photovoltaic device, and the digital X-ray detector is configured to determine one or more of a beginning, end, or duration of an image exposure via the photovoltaic device. | 03-06-2014 |
20150090890 | SYSTEM AND METHOD FOR ATTENUATION CORRECTION OF PHANTOM IMAGES - A method for attenuation correction of a phantom image in a PET imaging system includes obtaining raw scan data of a scanned phantom, a non attenuation corrected template image of a stock phantom of like type to the scanned phantom, and an attenuation map of the stock phantom. The method further includes generating a non-attenuation corrected raw image of the scanned phantom based on the raw scan data, registering the template image and attenuation map to the raw image through a rigid image transform, and applying the registered attenuation map to the raw scan data to enable reconstruction of an attenuation corrected final image. | 04-02-2015 |
Peter D. Spohn, Brookline, NH US
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20090072479 | MAT INCLUDING A COMPOSITE STRUCTURE - A mat includes a first surface having a first polymer, a second surface having a second polymer, and indicia associated with a game. The first polymer can include, for example, an elastomer, such as a silicone elastomer. The second polymer can include, for example, a fluorinated polymer. | 03-19-2009 |
Roman Spohn, Hermeskeil DE
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20130166468 | BUSINESS RULES-BASED DETERMINATION OF RETAIL AND WHOLESALE ALLOCATION - Methods and apparatus, including computer program products, are provided for receiving, at a shipping groups module, a sales order; processing, at the shipping groups module, the sales order to determine at least one shipping group based on at least one of a plurality of rules obtained from a rules module; and generating a shipping order including the at least one determined shipping group. Related apparatus, systems, methods, and articles are also described. | 06-27-2013 |
Ronald Spohn, Getzville, NY US
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20090211525 | MULTIPLE AMPOULE DELIVERY SYSTEMS - This invention relates to an integrated vapor or liquid phase reagent dispensing apparatus having a plurality of vessels and a plurality of carrier or inert gas feed/vapor or liquid phase reagent delivery manifolds, that may be used for continuously dispensing vapor or liquid phase reagents such as precursors for deposition of materials in the manufacture of semiconductor materials and devices. | 08-27-2009 |
20090214777 | MULTIPLE AMPOULE DELIVERY SYSTEMS - This invention relates to an integrated vapor or liquid phase reagent dispensing apparatus having a plurality of vessels and a plurality of carrier or inert gas feed/vapor or liquid phase reagent delivery manifolds, that may be used for continuously dispensing vapor or liquid phase reagents such as precursors for deposition of materials in the manufacture of semiconductor materials and devices. | 08-27-2009 |
20090214778 | MULTIPLE AMPOULE DELIVERY SYSTEMS - This invention relates to an integrated vapor or liquid phase reagent dispensing apparatus having a plurality of vessels and a plurality of carrier or inert gas feed/vapor or liquid phase reagent delivery manifolds, that may be used for continuously dispensing vapor or liquid phase reagents such as precursors for deposition of materials in the manufacture of semiconductor materials and devices. | 08-27-2009 |
20090214779 | MULTIPLE AMPOULE DELIVERY SYSTEMS - This invention relates to an integrated vapor or liquid phase reagent dispensing apparatus having a plurality of vessels and a plurality of carrier or inert gas feed/vapor or liquid phase reagent delivery manifolds, that may be used for continuously dispensing vapor or liquid phase reagents such as precursors for deposition of materials in the manufacture of semiconductor materials and devices. | 08-27-2009 |
Ronald F. Spohn, Getzville, NY US
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20080213476 | REAGENT DISPENSING APPARATUS AND DELIVERY METHOD - This invention relates to a vapor or liquid phase reagent dispensing apparatus comprising: | 09-04-2008 |
20110210142 | DIPTUBE APPARATUS AND DELIVERY METHOD - This invention relates to a vapor or liquid phase reagent dispensing apparatus having a diptube and also | 09-01-2011 |
20130334231 | CYLINDER PREPARATION FOR MAINTAINING STABILITY OF STORED MATERIALS - Novel cylinder passivation procedures to increase the room temperature stability of gaseous tin deuteride (SnD | 12-19-2013 |
20140165706 | PRESSURE INDICATING DEVICE - A pressure indicating device for detecting and isolating leakage of toxic and/or pyrophoric gasses from within various packages is disclosed. The device can affix to a user port of a cylinder package. The device has a flexible disc-like structure which is fine tuned to outwardly flex in response to a build-up of pressure of the gas exerted against the disc-like structure. The flexed disc contacts a movable pin and pushes the push outwards from within the device. The outward movement of the pin pierces a paper seal extending over the device, thereby indicating a leak from within the valving of the package. The device withstands the pressure exerted against it, thereby also isolating the leak of the pressurized gas. | 06-19-2014 |
William P. Spohn, Gibsonia, PA US
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20140262130 | SMART HVAC MANIFOLD SYSTEM - The smart HVAC manifold system for servicing air conditioning systems is designed to dynamically manage the data acquisition process and to measure and calculate the performance indicators and output as the load conditions and or equipment operation change taking into account variables in the installation that can impact performance. Both visually and by a very specific data set the performance of the equipment and the installation can quickly be assessed and specific problems identified along with suggestions of typical faults or problems that may need addressed by the technician. | 09-18-2014 |
20150292985 | SMART HVAC MANIFOLD SYSTEM - A smart manifold system for monitoring the operation of an HVAC unit includes a smart manifold adapted to obtain measurement data related to the operating conditions of the HVAC unit, and a smart platform adapted to communicate wirelessly with the smart manifold and acquire the measurement data from the smart manifold. The smart platform is also adapted to ensure that measurement data is free from any user manipulation or modification, and to tag any measurement data so ensured as verified data. The smart platform is further adapted to transmit the verified data to a remote platform for at least one of storage, report generation, and the performance of analytics. | 10-15-2015 |