Richards-Kortum
Rebecca Richards-Kortum, Houston, TX US
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20100039687 | Apparatus for Performing Confocal Endoscopy - A method for manufacturing a microscanner having a micro mirror is disclosed. Initially, a two-axis self-aligned vertical comb-drive microscanner is fabricated from a bonded silicon-on-insulator-silicon (SOI) silicon wafer. By depositing a thin film of aluminum on the surface, a SOI silicon wafer can provide about 90% reflectivity at 633 nm. A 2.5 μm misalignment tolerance can be achieved for the critical backside alignment step. As a result, confocal images with 1 μm resolution can be acquired using a microscanner having SOI silicon wafer mirrors. | 02-18-2010 |
20110206617 | MODIFIED POLYSACCHARIDES FOR DRUG AND CONTRAST AGENT DELIVERY - According to one embodiment, the disclosure provides a delivery formulation including a chitosan in which the primary amines are partially modified with 4-imidazole acetic acid monohydrochloride and a therapeutic or imaging material. According to another embodiment, the disclosure provides a method for delivering a material to an epithelial or mucosal tissue comprising increasing the permeability of an epithelial or mucosal tissue by applying to said tissue a delivery formulation including a chitosan in which the primary amines are partially modified with 4-imidazole acetic acid monochlorohydride and a therapeutic or imaging material. | 08-25-2011 |
20120065495 | NEEDLE BIOBSY IMAGING SYSTEM - Imaging techniques. Radiation is directed from a source onto a sample using an endoscope having cellular or subcellular resolution. The endoscope includes one or more fibers. The fibers have a proximate end and a distal end, and the distal end is lensless. A focal plane of the endoscope is substantially at a tip of the distal end. Radiation from the sample is directed onto a detector to diagnose or monitor the sample. | 03-15-2012 |
20120065521 | NEEDLE BIOBSY IMAGING METHOD - Imaging techniques. Radiation is directed from a source onto a sample using an endoscope having cellular or subcellular resolution. The endoscope includes one or more fibers. The fibers have a proximate end and a distal end, and the distal end is lensless. A focal plane of the endoscope is substantially at a tip of the distal end. Radiation from the sample is directed onto a detector to diagnose or monitor the sample. | 03-15-2012 |
20150041631 | READOUT & SIGNAL TRANSDUCTION (ROST) COMPONENT FOR POC DEVICES - A readout and signal transduction (ROST) component includes a universal fixture adapted to receive and align one or more optical elements and one or more opto-mechanical elements, wherein the optical elements and one or more opto-mechanical elements are stacked in the universal fixture, one or more optical elements configured for integration into the universal fixture; and one or more opto-mechanical elements configured for integration into the universal fixture. | 02-12-2015 |
Rebecca Richards-Kortum, Austin, TX US
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20090068108 | BIOSPECIFIC CONTRAST AGENTS - Methods and apparatuses for detecting a condition of a sample (including cervical cancers and pre-cancers) through reflectance and/or fluorescence imaging. A sample is obtained. One or more metallic nanoparticles and/or one or more quantum dots are obtained. The one or more metallic nanoparticles and/or one or more quantum dots are coupled to one or more biomarkers of the sample that are associated with the condition. A reflectance and/or fluorescence image of the sample is then taken. The image(s) exhibit characteristic optical scattering from the one or more metallic nanoparticles and/or characteristic fluorescence excitation from the one or more quantum dots to signal the presence of the one or more biomarkers. In this way, the condition can be readily screened or diagnosed. | 03-12-2009 |
Rebecca R. Richards-Kortum, Houston, TX US
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20120245530 | METHOD AND APPARATUS FOR DOSE MEASUREMENT - The present disclosure relates to devices for use in conjunction with a syringe in measuring a dose using the syringe. In certain embodiments, a clip is provided that includes an elongated portion for insertion into a barrel of a syringe and a locking portion that locks onto a feature of the syringe. Once inserted, the clip physically prevents retraction of a plunger of the syringe past a certain point corresponding to a desired dose. | 09-27-2012 |
Rebecca Rae Richards-Kortum, Houston, TX US
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20100210951 | Optical System for Imaging of Tissue Lesions - The present disclosure, according to one embodiment, relates to an optical device for direct visualization, imaging, and spectroscopic measurements of tissue abnormalities at various anatomical sites. Such sites include, but are not limited to, the oral cavity, the cervix, and the skin. In one embodiment, the device comprises: a frame; at least one light-emitting diode light source mounted on the frame for illuminating a tissue, wherein the at least one light-emitting diode light source is chosen from a fluorescent light source, a polarized white light source, and an unpolarized white light source; at least one loupe mounted on the frame for visually observing the tissue; at least one filter disposed between the tissue and the loupe for filtering light reflected from the tissue; and an energy source operably connected to the at least one light-emitting diode light source. | 08-19-2010 |
20120257188 | PAPER BASED SPECTROPHOTOMETRIC DETECTION OF BLOOD HEMOGLOBIN CONCENTRATION - The present disclosure relates to the use of a paper medium to measure blood hemoglobin concentration. In certain embodiments, spectrophotometric techniques are used to measure light transmission at specified wavelengths through a paper medium containing a blood sample. The light transmission information is then used in the calculation of blood hemoglobin concentration. In certain embodiments, the paper medium may be chemically treated to lyse the blood sample prior to measurement of the light transmission information. | 10-11-2012 |
20150025349 | PAD FOR MEASURING BLOOD LOSS - A pad is disclosed having a grid of absorbent structures (e.g., squares) formed on the pad. The pad may be used to quantify or otherwise assess blood loss by a patient. For example, blood lost by the patient and absorbed by the pad may be quantified by counting the number of saturated squares on the pad and taking into account the known absorbance of each square. | 01-22-2015 |