Hamilton, GB
Alan J. Hamilton, Bourton GB
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20130345329 | Rigid Polyurethane Foam and System and Method for Making the Same - An embodiment of a closed-cell polymeric rigid foam may be made using a one-shot method and a reaction system that includes a hydrofluoroalkene physical blowing agent and a polyol mixture having an aminic polyol. The hydrofluoroalkene blowing agent has 3 to 5 carbon atoms and a boiling point between 10° C. and 40° C. at 1 atmosphere pressure. Embodiments of rigid foams may have high closed cell content and are particularly well suited for thermal insulation. | 12-26-2013 |
Alan Lewis Hamilton, Buckinghamshire GB
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20090029866 | Libraries of oligomers labeled with different tags - A method of making a set of labelled compounds by the use of a preferably particulate support, comprises dividing the support into lots, performing a different chemical reaction on each lot of the support, e.g. to couple a chemical moiety to that lot of the support, tagging a fraction of each lot of the support with a different label, and combining the said lots of the support. The steps are repeated several times, preferably to build up oligomer molecules carrying labels which identify the nature and position of a monomer unit of the oligomer, and which are releasable from the support. Preferred labels, which are releasable from the compounds by cleavage to provide charged groups for analysis by mass spectrometry, are groups of the trityl (trimethylphenyl) family. Also claimed are libraries of these labels and their use in assays and nucleic acid analysis methods. | 01-29-2009 |
Alexander Samson Hamilton, Lancashire GB
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20130096884 | SENSOR DATA PROCESSING - Apparatus for and a method of processing sensor data, the method including: using a sensor, measuring values of a parameter over a region of interest to produce an image of the region of interest, the image having a plurality of pixels; for each pixel, determining an orientation of a gradient of the parameter, at that pixel, using the measured parameter values; for each of a plurality of predetermined ranges of gradient orientation values, determining a number of pixels that have a gradient orientation value within that range; identifying the predetermined ranges that correspond to a number of pixels above a threshold value; and for each identified predetermined range, identifying as corresponding to a feature of an object, pixels that have gradient orientation values within that predetermined range. | 04-18-2013 |
Andrea Hamilton, Wiltshire GB
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20110212491 | REACTION VESSEL - A reaction vessel for carrying out a chemical or biochemical reaction, such as a polymerase chain reaction, said vessel having a coating of parylene or a derivative thereof, on at least the surface which contacts reactants. | 09-01-2011 |
20120208192 | NUCLEIC ACID AMPLIFICATION EMPLOYING TEMPERATURE OSCILLATION - A method for carrying out an isothermal nucleic acid amplification reaction at a predetermined temperature, said method comprising changing the temperature of the reaction mixture away from the said predetermined temperature and allowing it to return to the predetermined temperature at least once during the amplification reaction so as to cause a temperature oscillation in particular of up to 15° C., for example of from 2-10° C. Apparatus adapted to carry out the method forms a further aspect of the invention. | 08-16-2012 |
Andrew Hamilton, Oxfordshire GB
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20130190355 | DUAL INHIBITORS OF FARNESYLTRANSFERASE AND GERANYLGERANYLTRANSFERASE I - Many GTPases such as Ras, Ral and Rho require post-translational farnestylation or geranylgeranylation for mediating malignant transformation. Dual farnesyltransferase (FT) (FTI) and geranylgeranyltransferase-I (GGT-1) inhibitors (GGTI) were developed as anticancer agents from based on an ethylenediamine scaffold. On the basis of a 4-fold substituted ethylenediamine scaffold, the inhibitors are structurally simple and readily derivatized, facilitating extensive structure-activity relationship studies. The most potent inhibitor is compound exhibited an in vitro hFTase IC | 07-25-2013 |
Andrew Hamilton, Oxford GB
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20110064694 | ANTI-HEPATITIS C ACTIVITY OF MESO-TETRAKIS-PORPHYRIN ANALOGUES - The present invention relates to porphyrin analogues, their use in pharmaceutical compositions alone, or combination with other agents and in the treatment and/or prophylaxis of flaviviridae viral infections, especially hepatitis C viral infection, and secondary disease states and/or conditions associated with same. | 03-17-2011 |
Andrew D. Hamilton, Oxfordshire GB
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20130295185 | COMPOUNDS AND METHODS FOR INDUCING APOPTOSIS IN CANCER CELLS USING A BH3 ALPHA-HELICAL MIMETIC - A novel BH3 α-helical mimetic, BH3-M6, which binds to Bcl-X | 11-07-2013 |
Andrew D. Hamilton, Oxford GB
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20110124602 | Stat3 Inhibitor Having Anti-Cancer Activity and Methods - A small-molecule Stat3 dimerization inhibitor, S3I-M2001, is described and the dynamics of intracellular processing of activated Stat3 within the context of the biochemical and biological effects of the Stat3 chemical probe inhibitor are elucidated. S3I-M2001 is a newly-identified oxazole-based peptidomimetic of the Stat3 Src Homology (SH) 2 domain-binding phosphotyrosine peptide that selectively disrupts active Stat3:Stat3 dimers. Stat3-dependent malignant transformation, survival, and migration and invasion of mouse and human cancer cells harboring persistently-activated Stat3 were inhibited by S3I-M2001. S3I-M2001 inhibited Stat3-dependent transcriptional regulation of tumor survival genes, such as Bcl-xL. The disclosed compound is useful as a new potential treatment for certain cancers. | 05-26-2011 |
20120035184 | METHODS FOR INDUCING TUMOR REGRESSION, INHIBITING TUMOR GROWTH, AND INDUCING APOPTOSIS IN BREAST TUMORS WITH GERANYLGERANYLTRANSFERASE I INHIBITORS - Methods of inducing tumor regression, inhibiting tumor growth, and inducing apoptosis with selective peptidomimetic inhibitors of geranylgeranyltransferase I (GGTase I), are provided. In one aspect, GGTI-2418 and its methylester GGTI-2417, increase levels of the cyclin-dependent kinase (Cdk) inhibitor p27 | 02-09-2012 |
Andrew John Hamilton, Norfolk GB
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20080312176 | GENE SILENCING - Methods are disclosed for gene silencing (e.g. post transcriptional gene silencing) in an organism using small RNA molecules. | 12-18-2008 |
20090286254 | GENE SILENCING - Methods are disclosed for screening for the occurrence of gene silencing (e.g., post transcriptional gene silencing) in an organism. Also provided are methods for isolating silencing agents so identified. | 11-19-2009 |
20090288182 | GENE SILENCING - Methods are disclosed for screening for the occurrence of gene silencing (e.g., post transcriptional gene silencing) in an organism. Also provided are methods for isolating silencing agents so identified. | 11-19-2009 |
20140331361 | GENE SILENCING - Compositions and methods are disclosed for effecting gene silencing (e.g., post transcriptional gene silencing) in an organism by targeting 15-20 nucleotides of mRNA. | 11-06-2014 |
Andrew R. Hamilton, Dundee GB
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20130013516 | SOCIAL NETWORK FINANCIAL PORTAL - A financial portal is provided which allows the transfer of funds between “friends” within a social network application. | 01-10-2013 |
Anita Hamilton, Aberdeen GB
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20090191187 | ANTIBODIES AGAINST INTERLEUKIN-1 RECEPTOR AND USES THEREOF - The present invention relates to antibodies against interleukin-1 receptor (IL-1R), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof. The antibodies of the present invention are particularly useful for treating a variety of inflammatory diseases including, but not limited to, rheumatoid arthritis. | 07-30-2009 |
Anita A. Hamilton, Aberdeen GB
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20080248529 | MODIFIED ANTI-CD52 ANTIBODY - The present invention provides for modified forms of anti-CD52 antibodies with reduced numbers of potential T-cell epitopes that are expected to display decreased immunogenicity. | 10-09-2008 |
20090022738 | Multispecific deimmunized CD3-binders - The present invention provides a cytotoxically active CD3 specific binding construct comprising a first domain specifically binding to human CD3 and an Ig-derived second binding domain. Furthermore, a nucleic acid sequence encoding a CD3 specific binding construct of the invention is provided. Further aspects of the invention are vectors and host cells comprising said nucleic acid sequence, a process for the production of the construct of the invention and composition comprising said construct. The invention also provides the use of said constructs for the preparation of pharmacutical compositions for the treatment of particular diseases, a method for the treatment of particular diseases and a kit comprising the binding construct of the invention. | 01-22-2009 |
20090092546 | Carrier molecules - The present invention relates generally to carrier molecules derived from one animal or avian species or strains and which are substantially non-immunogenic when exposed to an immune system from a species or strain of another animal or avian creature. More particularly, the present invention provides deimmunized immunointeractive molecules and even more particular deimmunized antibodies for use in diagnostic and therapeutic applications. | 04-09-2009 |
20100016562 | REDUCING THE IMMUNOGENICITY OF FUSION PROTEINS - Disclosed are compositions and methods for producing fusion proteins with reduced immunogenicity. Fusion proteins of the invention include a junction region having an amino acid change that reduces the ability of a junctional epitope to bind to MHC Class II, thereby reducing its interaction with a T-cell receptor. Methods of the invention involve analyzing, changing, or modifying one or more amino acids in the junction region of a fusion protein in order to identify a T-cell epitope and reduce its ability to interact with a T cell receptor. Compositions and methods of the invention are useful in therapy. | 01-21-2010 |
20100286375 | Carrier molecules - The present invention relates generally to carrier molecules derived from one animal or avian species or strains and which are substantially non-immunogenic when exposed to an immune system from a species or strain of another animal or avian creature. More particularly, the present invention provides deimmunized immunointeractive molecules and even more particular deimmunized antibodies for use in diagnostic and therapeutic applications. | 11-11-2010 |
20120309936 | REDUCING THE IMMUNOGENICITY OF FUSION PROTEINS - Disclosed are compositions and methods for producing fusion proteins with reduced immunogenicity. Fusion proteins of the invention include a junction region having an amino acid change that reduces the ability of a junctional epitope to bind to MHC Class II, thereby reducing its interaction with a T-cell receptor. Methods of the invention involve analyzing, changing, or modifying one or more amino acids in the junction region of a fusion protein in order to identify a T-cell epitope and reduce its ability to interact with a T cell receptor. Compositions and methods of the invention are useful in therapy. | 12-06-2012 |
20130224205 | MULTISPECIFIC DEIMMUNIZED CD3-BINDERS - The present invention provides a cytotoxically active CD3 specific binding construct comprising a first domain specifically binding to human CD3 and an Ig-derived second binding domain. Furthermore, a nucleic acid sequence encoding a CD3 specific binding construct of the invention is provided. Further aspects of the invention are vectors and host cells comprising said nucleic acid sequence, a process for the production of the construct of the invention and composition comprising said construct. The invention also provides the use of said constructs for the preparation of pharmaceutical compositions for the treatment of particular diseases, a method for the treatment of particular diseases and a kit comprising the binding construct of the invention. | 08-29-2013 |
Arnott Hamilton, Paisley GB
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20130104409 | COMPASS | 05-02-2013 |
Bruce Hamilton, Cambridge GB
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20120276098 | DRUG FUSIONS AND CONJUGATES WITH EXTENDED HALF LIFE - The present invention relates to drug fusions and conjugates that have improved serum half lives. These fusions and conjugates comprise immunoglobulin (antibody) single variable domains and insulinotropic and/or incretin and/or gut peptide molecules. The invention further relates to uses, formulations, compositions and devices comprising such drug fusions and conjugates. The invention also relates to compositions which comprise more than one insulinotropic and/or incretin and/or gut peptide molecules present as part of a fusion or conjugate and to uses and formulations thereof. | 11-01-2012 |
20130189255 | FUSIONS AND CONJUGATES OF INSULINOTROPIC AGENTS - The present invention relates to drug fusions of insulinotropic agents and incretin drugs that have improved serum half lives. These fusions and conjugates comprise polypeptides, immunoglobulin (antibody) single variable domains and GLP and/or exendin molecules. The invention further relates to uses, formulations, compositions and devices comprising such drug fusions and conjugates. | 07-25-2013 |
Bruce J. Hamilton, Cambridgeshire GB
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20140193407 | DRUG FUSIONS AND CONJUGATES - The present invention relates to drug fusions that have improved serum half lives. These fusions and conjugates comprise polypeptides, immunoglobulin (antibody) single variable domains and GLP and/or exendin molecules. The invention further relates to uses, formulations, compositions and devices comprising such drug fusions and conjugates. | 07-10-2014 |
Carol J. Hamilton, Wormit GB
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20090164250 | Device management portal, system and method - A device management system comprises a processor, a data storage device and a network connection. The data storage device stores weighting data associated with at least one ATM. The processor receives performance metric data from the ATM via the network connection and accesses the weighting data from the data storage device. The processor weights a portion of the performance metric data associated with the ATM with respect to a portion of weighting data associated with the ATM, to produce weighted performance data. The weighted performance data is used in estimating the number of customers unserved during a period of downtime of the ATM. | 06-25-2009 |
Christian Hamilton, Basingstoke GB
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20140155049 | Method and Apparatus for Adjusting Layer 3 Filter Coefficients - A UE configured to adjust a L3 filter coefficient, comprises initializing a first filter coefficient of a first filter and a second filter coefficient of a second filter based on a primary filter coefficient of a primary filter received from an associated wireless network entity; adjusting the primary filter coefficient by one of: setting the primary filter coefficient to the first filter coefficient if a first difference between a measurement result of the primary filter and a first measurement result of the first filter is less than a first coefficient threshold and setting the primary filter coefficient to the second filter coefficient if a second difference between the measurement result of the primary filter and a second measurement result of the second filter is less than a second coefficient threshold; and applying the adjusted primary filter coefficient to measurements of one or more cells in an active cell set. | 06-05-2014 |
Christian Alexander Hamilton, Basingstoke GB
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20140092873 | Method, Apparatus and Computer Program for Controlling a Communications State of an Apparatus - A method, apparatus and computer program are provided for controlling a communications state of an apparatus with respect to a serving cell in a communications network. The apparatus is configured with a first and second, different signal threshold, wherein the first and second signal thresholds are dependent on a reference signal. A value of a signal associated with at least one cell in the communications network is monitored. A timer is configured with a first operative state when the monitored signal value is determined to exceed the first signal threshold and a second operative state when the monitored signal value is determined to be lower than the second signal threshold. Responsive to a value of the timer satisfying a predetermined time parameter, the communications state of the apparatus with respect to its serving cell is adjusted. | 04-03-2014 |
Christopher James Hamilton, Edlington GB
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20100071113 | EXERCISE GARMENT - Exercise garment made from a thin, lightweight fabric that is free of lead, cadmium, chromium and mercury. The exercise garment may be a vest, jacket, shirt, pants, shorts, one-piece bodysuit or similar suitable garment. The exercise garment may be form-fitting for a man or woman and is suitable for a user to wear underneath other garments during exercise. An exercise garment of the present invention promotes weight reduction through increasing generation and retention of heat and perspiration by a user during exercise. | 03-25-2010 |
Clive Alexander Hamilton, Swainby GB
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20110160390 | PROCESS FOR PRODUCTION OF POLYESTERS WITH LOW ACETALDEHYDE CONTENT AND REGENERATION RATE - The present invention relates to a process for producing a polyester comprising: (a) forming a polyester in a melt phase having an intrinsic viscosity of about 0.65 or more, provided that said forming is not by solid state polymerization; and (b) adding an anhydride to the polyester during the melt phase. The present invention also includes articles comprising a composition produced by processes of the present invention. | 06-30-2011 |
20120115997 | PROCESS FOR PRODUCTION OF POLYESTERS - The present invention relates to a process for producing a polyester comprising: (a) forming a polyester with an intrinsic viscosity of at least about 0.65, wherein said forming of the polyester comprises use of a catalyst; and (b) adding a phosphorous compound to the polyester after the forming of step (a), wherein said phosphorous compound comprises at least one member selected from the group consisting of trialkyl phosphate, trialkyl phosphonoacetate, monoalkyl phosphate, dialkyl phosphate, trialkyl phosphite, triaryl phosphite, tris alkylaryl phosphite, and mixtures thereof. The present invention also includes compositions produced by process of the present invention and articles comprising those compositions. | 05-10-2012 |
20140005352 | GAS SCRUBBER AND RELATED PROCESSES | 01-02-2014 |
20140378712 | ALKANOLYSIS PROCESS - The present invention provides an improved process for converting a diester of polyether polyol, e.g., PTMEA, to the corresponding dihydroxy product, e.g., polytetramethylene ether glycol (PTMEG) continuously in a reaction zone, such as, for example, a reactive distillation system, for achieving virtually complete conversion of PTMEA to PTMEG, and recovery of PTMEG free of unreacted or unconverted PTMEA and alkanol ester by-product. | 12-25-2014 |
20150051367 | VARIABLE PRESSURE DROP UP FLOW-PRE-POLYMERIZER (UFPP) SYSTEMS AND METHODS - Disclosed are processes and systems for manufacturing polyethylene terephthalate (PET) and pre-polymer. The processes and systems use a variable pressure drop up-flow-pre-polymerizer configuration. The pressure profile in the UFPP can be selected to beneficially change the relative reaction rates of the polymerization and esterification reactions. This design maximizes the esterification carried out in the UFPP, while still producing a pre-polymer with the optimum carboxyl end groups concentration (e.g., about 30μ equiv./g to 60μ equiv./g) to maximize finisher productivity. This can result in a reduction of the size and cost of the esterifier required for a given plant throughput. | 02-19-2015 |
Craig Hamilton, Glasgow GB
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20140016185 | SEMICONDUCTOR DISK LASER FOR NONLINEAR MICROSCOPY APPLICATIONS IN LIVING ORGANISMS - A mode locked semiconductor disk laser with an output beam having an ultra-short pulse length which provides the incident beam to a non linear microscope. The wavelength of the beam is at or near the action cross section maximum absorption wavelength for creating two photon excited fluorescence of a fluorescent biological marker in a sample. Semiconductor disk lasers combine excellent beam quality and output power, stability while maintaining simplicity and easiness of operation. In addition, these types of lasers are ideally suited for mass production as they are built in wafer-scale technology enabling a high level of integration. Importantly this non expensive, turn-key, compact laser system could be used as a platform to develop portable non-linear bio-imaging devices for clinical studies, facilitating its wide-spread adoption in “real-life” applications. | 01-16-2014 |
David Hamilton, Edinburgh GB
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20100328121 | CIRCUIT TESTING - A method for testing a circuit that generates an n-bit pulse density modulated output in response to an input signal or combination of input signals, for example the analogue section ( | 12-30-2010 |
20110231153 | ADC Testing - A histogram-based method for testing an electronic converter device, such as an analogue to digital converter, includes steps of defining at least one histogram hyperbin arranged to store hits for at least one subrange of output codes; applying an input test stimulus to an input of the device to test a subrange of output codes matched to the hyperbin; and accumulating the histogram. At least two hyperbins may be provided, each bin being arranged to store hits for at least one subrange of output codes, and the input test stimulus is applied to an input of the device to test a subrange of output codes matched to one of the hyperbins. Both hyperbins may be open while the histogram is being accumulated for any subrange of output codes. The method may further involve varying the input stimulus to test another subrange. | 09-22-2011 |
20140203954 | ADC TESTING - A histogram-based method for testing an electronic converter device, such as an analogue to digital converter, includes steps of defining at least one histogram hyperbin arranged to store hits for at least one subrange of output codes; applying an input test stimulus to an input of the device to test a subrange of output codes matched to the hyperbin; and accumulating the histogram. At least two hyperbins may be provided, each bin being arranged to store hits for at least one subrange of output codes, and the input test stimulus is applied to an input of the device to test a subrange of output codes matched to one of the hyperbins. Both hyperbins may be open while the histogram is being accumulated for any subrange of output codes. The method may further involve varying the input stimulus to test another subrange. | 07-24-2014 |
David Alexander Hamilton, London GB
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20140096461 | HOTEL ROOMS - An improved hotel configuration. The hotel room configuration includes two adjacent rooms, one of which forms a T, and the other of which forms an L, with the base of the T fitting into the right angle formed by the L. Embodiments are directed to reconfiguring an existing hotel having adjacent, side-by-side rooms into the T and L configuration. Additional embodiments are directed to a combined television stand and desk module that fits into or is used as a footboard of a bed. A television can be mounted on the top of this console, and can, in embodiments, rotate to face the desk, the bed, or other parts of the room. | 04-10-2014 |
Dougal Hamilton, Cheshire GB
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20130112868 | ION DETECTION ARRANGEMENT - A mass spectrometer is disclosed having a mass analyser with a mass-to-charge dispersive element for separating ions according to their mass-to-charge ratios along a dispersive plane and an ion deflector to deflect ions leaving the mass analyser in the dispersive plane. A shielding arrangement, located between the dispersive element and the ion deflector is arranged to define the portion of the beam to be deflected by the ion deflector. The deflected beam is steered onto a beam defining aperture, located at the focal plane of the mass analyser is detected by at least one ion detector, located downstream from the beam defining aperture. | 05-09-2013 |
Edward Keith Hamilton, Edlington GB
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20100071113 | EXERCISE GARMENT - Exercise garment made from a thin, lightweight fabric that is free of lead, cadmium, chromium and mercury. The exercise garment may be a vest, jacket, shirt, pants, shorts, one-piece bodysuit or similar suitable garment. The exercise garment may be form-fitting for a man or woman and is suitable for a user to wear underneath other garments during exercise. An exercise garment of the present invention promotes weight reduction through increasing generation and retention of heat and perspiration by a user during exercise. | 03-25-2010 |
Edwin Stuart Hamilton, Sudbury GB
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20090173342 | EMERGENCY BREATHING APPARATUS - An emergency breathing apparatus for skiers which is a device for attachment to an item of clothing, or in a ski pole or walking pole, which is adapted to enable a user to breathe in the event of being trapped in an avalanche. The emergency breathing apparatus comprises a conduit and a mouthpiece construction comprising a body member and a mouthpiece member. The mouthpiece member is in fluid communication with the conduit and is moveable between a compressed position at or near the body member and an extended position where it is located away from the body member, and allows a user to exhale through the conduit. | 07-09-2009 |
Gordon Blackwood Hamilton, Woodbridge GB
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20080303318 | Personal Seated Resting Support - The present invention relates to a resting support ( | 12-11-2008 |
Gordon Blackwood Hamilton, Suffolk GB
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20120012431 | PERSONAL SEATED RESTING SUPPORT - The present invention relates to an item of luggage ( | 01-19-2012 |
Guy Michael Gary Hamilton, Glasgow GB
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20090010889 | Treatment Using Herpes Simplex Virus - The use of Herpes Simplex Virus (HSV) in the treatment of tumour by extratumoural administration of said HSV, and the use of HSV in treatment of tumour by combination therapy with a pharmaceutical wherein the HSV and/or pharmaceutical is administered at an extratumoural location, is disclosed. | 01-08-2009 |
20110158948 | Treatment Using Herpes Simplex Virus - Herpes Simplex Viruses are disclosed having single-chain antibodies (scFv) embedded in the viral envelope via fusion with glycoprotein D and with glycoprotein H and L. | 06-30-2011 |
Hugh Gavin Charles Hamilton, Reading GB
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20100229722 | METHOD FOR REMOVING HEAVY METALS FROM GASES - In the removal of heavy metals such as mercury from fluid streams, especially coal-derived syn-gas streams, a sulphided palladium-containing absorber gives improved results by way of mercury-absorption capacity if the absorber is sulphided. | 09-16-2010 |
20110281132 | METHOD FOR COATING PARTICLES - The present invention relates to a method for coating primary particles with secondary particles using dual asymmetric centrifugal forces wherein, the primary particles comprise (a) at least one metal, or (b) at least one ceramic; the secondary particles comprise at least one metal or salt thereof; and wherein the secondary particles are more malleable than the primary particles. | 11-17-2011 |
20120258008 | METHOD OF CONTROLLING THE CARBON OR OXYGEN CONTENT OF A POWDER INJECTION - The present invention relates to a method for controlling the carbon and/or oxygen content in a material by | 10-11-2012 |
Ian Hamilton, North Yorkshire GB
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20130053984 | PROSTHETIC APPARATUS AND ARTIFICIAL JOINT - An artificial joint with two degrees of freedom has two rotary motors that move the joint in one degree of freedom when operated in respective senses of rotation and move the joint in the other degree of freedom when one of the motors is reversed. The movement depends on balancing the operation of the motors, which are controlled by a microprocessor. Sensors on the joint are connected to the microprocessor in a closed-loop feedback. A prosthetic device includes a tendon received in one end of a slot in a movable member, whereby movement of the tendon moves the movable member. A prosthesis has two parts moveable relative to one another, an actuator, and a user control. A transducer connected to the control and the actuator provides signals indicating movement effected by the actuator. A prosthesis cover includes a silicone laminate and a reinforcing liner. | 02-28-2013 |
Jacqueline Fiona Hamilton, York GB
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20110143952 | CHROMATOGRAPHIC DEVICE AND METHOD OF FABRICATION AND CHROMATOGRAPHIC METHODS - A chromatographic device for use in multi-dimensional GC is described having a gas flow channel means having an inlet and an outlet, and including a first length of tube defining a first stage and a second length of tube defining a second stage; wherein each of the first length of tube defining a first stage and second length of tube defining a second stage is microfabricated in the plane of a planar substrate layer such that each length of tube comprises a bore defining a closed curve in cross section. A GC assembly further comprising modulator, injector and detector and a method of fabrication of device and assembly are described. A method of analysing multi-dimensional GC data is described. | 06-16-2011 |
James Hamilton, West Yorkshire GB
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20140261778 | High Integrity Pressure Protection System (HIPPS) Manifold System and Method - Embodiments of the invention provide a high integrity pressure protection system (HIPPS) manifold including a housing providing a flow path between a process fluid line and a sensor, a first ball valve positioned within the housing and selectively allowing and inhibiting flow through the flow path, and a second ball valve positioned within the housing and selectively allowing and inhibiting flow through the flow path. | 09-18-2014 |
James Hamilton, Monmouthsire GB
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20130200226 | INFLATABLE APPARATUS FOR HOLDING A DEVICE - An inflatable apparatus, for use in supporting a device such as a sex toy, the inflatable apparatus comprising: an inflatable portion which serves as a main structural element of the apparatus; a holding portion which extends into the inflatable portion, and which defines a holding aperture bounded by a holding surface, the holding surface being adapted for frictional engagement with a device inserted into the holding aperture, wherein the holding portion is adjustable such that such frictional engagement can be adjusted. | 08-08-2013 |
James Gordon Campbell Hamilton, Alderley Edge GB
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20100310620 | INSECT ATTRACTANTS AND THEIR USE IN METHODS OF INSECT CONTROL - The present invention utilizes a fatty acid as an attractant in a method of attracting whiteflies. By using a fatty acid as a whitefly attractant, it is possible to attract whiteflies to a desired location. The fatty acid can be used in a lure or other propagator to provide a dispersion of fatty acid in the air, the variation in the concentration of the fatty acid in the air being such that a whitefly is attracted to the lure as the source of the fatty acid. The use of a fatty acid as an attractant results in significantly higher levels of attraction, as measured by the number of whiteflies attracted to a sticky trap, as compared to the use of colour alone. | 12-09-2010 |
James Gordon Campbell Hamilton, Cheshire GB
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20120263773 | INSECT ATTRACTANTS AND THEIR USE IN METHODS OF INSECT CONTROL - The present invention utilizes a fatty acid as an attractant in a method of attracting whiteflies. By using a fatty acid as a whitefly attractant, it is possible to attract whiteflies to a desired location. The fatty acid can be used in a lure or other propagator to provide a dispersion of fatty acid in the air, the variation in the concentration of the fatty acid in the air being such that a whitefly is attracted to the lure as the source of the fatty acid. The use of a fatty acid as an attractant results in significantly higher levels of attraction, as measured by the number of whiteflies attracted to a sticky trap, as compared to the use of colour alone. | 10-18-2012 |
John Hamilton, Stirling GB
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20110113977 | Emulsion Ink - The present invention is directed to a water-in-oil (w/o) emulsion ink comprising an oil phase and an aqueous phase. The oil phase comprises a liquid resin having a viscosity in the range of from about 1000 to about 10000 centipoise (cP) in an amount of about 0.1 to about 10 weight % as based upon the total mass of the ink. The aqueous phase comprises pigment. When the pigment comprises carbon black, all of the carbon black pigment contained within the ink has a pH of at least about 5. The invention is also directed to a process for the preparation of a w/o emulsion ink, which comprises adding an aqueous phase to an oil phase. The oil phase comprises a resin which, during manufacture of the ink, is added to the oil phase as a liquid having a viscosity in the range of from about 1000 to about 10000 cP, and the ink comprises pigment which, during manufacture of the ink, is added to the aqueous phase. When the pigment comprises carbon black, all of the carbon black pigment has a pH of at least about 5. The inks find particular use in stencil printing, and in particular in digital duplication. | 05-19-2011 |
John Hamilton, Portlethen Aberdeenshire GB
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20130195557 | METHOD OF MANUFACTURING A MECHANICALLY LINED PIPE - A method of manufacturing a mechanically lined pipe (MLP) having an outer pipe and an inner liner comprising at least the steps of: (a) forming the outer pipe as a single length; (b) forming an inner liner former being wholly or substantially the same length as the outer pipe of step (a); (c) locating the inner liner former of step (b) within the outer pipe; and (d) expanding the inner liner former within the outer pipe to form the MLP. In this way, the conventional need to overcome problems with welding a number of pre-formed 12 m or 24 m bi-metallic pipe stalks to form a 1 km bi-metallic pipe are avoided, thus also avoiding weaknesses that can be a part of conventional stalk-welding processes for forming an MLP. | 08-01-2013 |
Keith A. Hamilton, Claygate GB
Patent application number | Description | Published |
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20130291030 | MULTIZONE AUDIO-VISUAL SYSTEM - A multi-zone audio-visual (AV) system that includes: (a) one or more AV devices (such as a TV) operable to provide audio and/or visual information; (b) a set-top box (STB) associated with each AV device; (c) a router; (d) an Ethernet connection between each STB and the router; and (e) a control server which operates to receive and record data from the router, the data including data indicative of the operating status (e.g., on or off) of the or each AV device, the operating configuration (e.g., TV channel) and the time of each change of status and/or configuration of the or each AV. The system comprises at least two remote AV control devices (Human Interface Devices, “HIDs”) for each AV device. The HIDs associated with each AV device operate to be automatically synchronised to the same status and configuration. The system may include a web server and a content server. | 10-31-2013 |
Keith Alistair Hamilton, Walton-On-Thames GB
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20120313781 | SURVEILLANCE SYSTEM AND METHOD - A surveillance method and system is provided for receiving image data from a plurality of said cameras; storing the received image data identifying each camera from which the image data originated; enabling each of a plurality of camera users who own or operate respective cameras to assign a said camera owned or operated by the camera user to at least one said set of cameras and to authorise selected users of the system to access image data from said at least one set of cameras, wherein said users of the system can include camera users and/or users not owning or operating any cameras; storing camera set data identifying the assigned camera as belonging to said set of cameras; storing user data identifying the users authorised to access image data from said set of cameras; and outputting image data to users dependent upon said camera set data and said user data. | 12-13-2012 |
Kelvin Hamilton, Edinburgh GB
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20100306588 | Intelligent Integrated Diagnostics - A diagnostic tools and methods are disclosed. The diagnostic tool is configured or operable to nominate a commonly connected component in a target system as being faulty if more than a pre-determined number of active components connected to the commonly connected component appear faulty. | 12-02-2010 |
Kevin M. Hamilton, Belfast GB
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20140068035 | MANAGING NETWORK CONFIGURATIONS - Provided are systems, methods and computer program products that proactively manage configurations that enable a service. Configurations that are critical to enabling a particular service are automatically captured, for example as part of a provisioning activity, and/or tracked in association with that service. This automated, service-oriented configuration management enables improved service assurance and faster identification of problems, and mitigates the problem of errors and compromised service delivery that can arise from misconfigurations. | 03-06-2014 |
20140095677 | CONFIGURATION COMMAND TEMPLATE CREATION ASSISTANT USING CROSS-MODEL ANALYSIS TO IDENTIFY COMMON SYNTAX AND SEMANTICS - In one embodiment, a computer program product for creating a configuration template for a set of devices includes a computer readable storage medium having computer readable program code embodied therewith, the computer readable program code including computer readable program code configured for determining command information for a plurality of devices, computer readable program code configured for identifying a command structure from the command information which is common to a set of devices from the plurality of devices, and computer readable program code configured for associating the set of devices to a common configuration template. In another embodiment, a method for creating a configuration template for a set of devices includes determining command information for a plurality of devices, identifying a command structure from the command information which is common to a set of devices from the plurality of devices, and associating the set of devices to a common configuration template. | 04-03-2014 |
20140325042 | Robust Service Deployment - A method, system and program product for deploying a service on a network comprising a plurality of network resources, the method comprising providing an actual network model comprising network resources and the configurations of the network resources; providing a computer-implemented network configuration management system controlling the actual network resource configurations in the actual model; providing a service description comprising network resource configuration information for implementing the service on specific network resources; selecting a set of available network resources for deploying the service in the network based on the service description; reserving available network resources for deploying the service in an off-line version of the actual network model, the off-line version including updated network resource configurations to reflect the changes to the configurations of the actual network resources triggered by the deployment of the service; and deploying the service by updating the actual network model using the off-line version. | 10-30-2014 |
20140379881 | Network Device Configuration Management - Method and system are provided for network device configuration management. The method includes: receiving a set of user commands for configuration of a network device; retrieving a syntactic model of a network device configuration interface for a network device type and generating a modelled configuration of a current configuration of the network device; predicting the effect of the user command on the modelled configuration to generate a predicted modelled configuration; and applying rules for a user and/or network device type to determine if the command is permitted based on the predicted modelled configuration of the network device. Predicting the effect of the user command predicts in near real-time the effect on the network device configuration of a command that the user enters. | 12-25-2014 |
Lesley Michelle Hamilton, Syresham GB
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20090017315 | HEAT RESISTANT COATING - The present invention relates to coating compositions comprising a polysiloxane, a alkyl titanate, talc and/or mica, aluminium flakes, and optionally an alkyl orthosilicate or a condensation product thereof. The invention also relates to steel sub-strates coated with these coating compositions. | 01-15-2009 |
Lloyd George Hamilton, Nottingham GB
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20090010863 | Cosmetic Compositions - There is disclosed a skincare composition suitable for topical application to the skin. The composition comprises two or more active ingredients selected from the group consisting of a) dipalmitoyl hydroxyproline, salts and esters thereof; b) carnitine; and c) an extract of | 01-08-2009 |
20110189323 | COSMETIC COMPOSITIONS - There is disclosed a skincare composition suitable for topical application to the skin. The composition comprises two or more active ingredients selected from the group consisting of a) dipalmitoyl hydroxyproline, salts and esters thereof; b) carnitine; and c) an extract of | 08-04-2011 |
Mark Hamilton, Pershore GB
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20120076702 | Sterilisation and Decontamination Device - A sterilisation, sanitisation and/or decontamination device ( | 03-29-2012 |
Mark Hamilton, Orkney GB
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20110131970 | WATER CURRENT POWERED GENERATING APPARATUS - A power generating apparatus ( | 06-09-2011 |
Mark Hamilton, Hopewell Junction GB
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20110212053 | PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS - Provided are compounds according to Formula (I): | 09-01-2011 |
Nicola May Hamilton, West Sussex GB
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20100147208 | Road Safety Device - An elasticated, high-visibility band is stretched over the rear boot of a car, providing a highly-visible X to alert other road users. The band is in the form of two connected loops or of one loop with two ties for attachment to the car. | 06-17-2010 |
Nigel Hamilton, Kilburn GB
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20090030876 | METHOD AND SYSTEM FOR RECORDING SEARCH TRAILS ACROSS ONE OR MORE SEARCH ENGINES IN A COMMUNICATIONS NETWORK - An automated method for recording sites accessed by a client in a communications network, the method including the steps of: detecting submission of a search query ( | 01-29-2009 |
20140032519 | METHOD AND SYSTEM FOR RECORDING SEARCH TRAILS ACROSS ONE OR MORE SEARCH ENGINES IN A COMMUNICATIONS NETWORK - An automated method for recording sites accessed by a client in a communications network, the method including the steps of: detecting submission of a search query ( | 01-30-2014 |
Rick Hamilton, Southampton GB
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20090066890 | TRANSFLECTIVE LCD COMPRISING A PATTERNED RETARDATION FILM - The invention relates to a transflective liquid crystal display (LCD) with a polymerised LC film comprising at least one photoisomerisable compound and having a pattern of regions with different retardation and/or different orientation of the LC material. | 03-12-2009 |
20090073352 | TRANSFLECTIVE VERTICALLY ALIGNED LIQUID CRYSTAL DISPLAY WITH IN-CELL PATTERNED QUARTER-WAVE RETARDER - The invention relates to a transflective vertically aligned (VA) liquid crystal display (LCD) comprising a patterned quarter wave foil (QWF). The display ( | 03-19-2009 |
20090262284 | TRANSFLECTIVE LIQUID CRYSTAL DISPLAY - The invention relates to a transflective liquid crystal display (LCD) comprising a patterned quarter wave foil (QWF) and having improved chromaticity. | 10-22-2009 |
Robert Hamilton, London GB
Patent application number | Description | Published |
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20110301728 | CONTINUOUS AUDIO INTERACTION WITH INTERRUPTIVE AUDIO - According to an example implementation, a method may include playing, by a computing device, first audio generated by a first application, determining that the first audio generated by the first application should be interrupted based on a notification associated with a second application, pausing the first audio generated by the first application, playing interruptive audio generated by the second application during the pausing of the first audio, identifying a portion of the first audio that was previously played before the first audio was paused, and resuming the playing of the first audio so that the portion of the first audio that was previously played is replayed. | 12-08-2011 |
20120029672 | CONTINUOUS AUDIO INTERACTION WITH INTERRUPTIVE AUDIO - According to an example implementation, a method may include playing, by a computing device, first audio generated by a first application, determining that the first audio generated by the first application should be interrupted based on a notification associated with a second application, pausing the first audio generated by the first application, playing interruptive audio generated by the second application during the pausing of the first audio, identifying a portion of the first audio that was previously played before the first audio was paused, and resuming the playing of the first audio so that the portion of the first audio that was previously played is replayed. | 02-02-2012 |
Robert John Hamilton, Surrey GB
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20090218410 | ANCHORING DEVICES FOR RAIL FASTENING CLIPS - A shoulder for use in retaining a railway rail fastening clip, comprising two interconnected spaced-apart walls, between which a portion of the clip to be retained is held when the shoulder is in use, and clip-engaging means, supported by the walls, for engaging a portion of the clip to be retained, does not have any feature or surface which engages the surface of that clip portion which faces downwardly when the clip is in use. Alternatively, or in addition, none of the contact regions, at which the device engages the rail clip, can be seen when the anchoring device is viewed from above when in its operative orientation and all of the contact regions can be seen when the anchoring device is viewed from below when in the operative orientation. Alternatively, or in addition, all the contact regions lie substantially at the same horizontal distance from the edge of the rail foot when measured perpendicularly to the axis of the rail and in the plane of the rail foot. | 09-03-2009 |
20090261177 | RAILWAY RAIL PAD - A rail pad is disclosed having two upstanding portions, integrally formed with the rail seat portion along opposite edges thereof, so as to extend along only a central part of the edge. Preferably, the upstanding portions are attached to the rail seat portion in such a manner as to be readily detachable therefrom. | 10-22-2009 |
20100181386 | COMPONENTS FOR RAIL FASTENING ASSEMBLY - A component for use in a rail fastening assembly, the assembly comprising a railway rail fastening clip having a first part for bearing on a railway rail and a railway rail clip anchoring device for retaining the railway rail clip, comprises a first portion adapted to receive a lateral load from the rail when located between a substantially upright face of the rail clip anchoring device and the side of the foot of an adjacent railway rail when the assembly is in use. The component further comprises a second portion for receiving a second bearing part of the railway rail clip. The first portion and the second portion of the component are spaced apart and interconnected by a connection portion. | 07-22-2010 |
20100206958 | RAILWAY RAIL PAD - In a railway rail pad having a rail seat portion for receiving a foot of a railway rail, the rail seat portion is provided on at least one major face thereof with a plurality of protrusions which are unevenly distributed across the face of the rail seat portion such that the ratio of the area of the face occupied by the protrusions to the area of the face free of protrusions is greater in an edge region of the rail seat portion than in a central region of the rail seat portion, the edge region being adjacent to one edge of the pad and the central region being adjacent to the edge region. The studs are arranged in columns, each stud being of substantially the same size, and the number of studs in a column in the central region which is closest to said edge region being greater than in a column closer to the centre of the rail seat portion. The studs are also arranged in rows, wherein the ratio of protrusions to free area in a row of studs adjacent to, but spaced from, the centre of the rail seat portion is greater than that in a row further from the centre. | 08-19-2010 |
Robert John Hamilton, Woking GB
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20120181344 | INSULATOR FOR RAILWAY FASTENING CLIP AND RAILWAY RAIL FASTENING CLIP FOR USE THEREWITH - An electrical insulator for use with a rail fastening clip comprises a contact member providing on one side a substantially flat rail contact surface for contacting a foot of a rail and on the opposing side a clip contact surface for contacting a rail bearing surface of a bearing portion of the clip, the insulator also having retaining means for retaining the insulator on the clip in such a way as to allow rotation of the insulator about a longitudinal axis of the bearing portion of the clip. The insulator has stop portions for limiting such rotation about the longitudinal axis of the bearing portion of the clip to a desired extent. The clip contact surface of the insulator is convex, in a vertical plane which is perpendicular to the longitudinal axis of the bearing portion of the clip, such that, when the insulator is attached to a clip having a flat rail bearing surface, a contact region between the flat rail bearing surface of the clip and the clip contact surface of the insulator is linear. The insulator is rockable about the linear contact region within the extent defined by the stop portions such that, when the rail contact surface of the insulator contacts the surface of a rail foot, the angle of the rail contact surface can conform to the angle of the rail foot surface. A rail fastening clip, suitable for use with the insulator and of the kind driven onto a rail in a direction which is parallel to a longitudinal axis of the rail, has a bearing portion having a flat rail bearing surface, wherein a detent, extending laterally with respect to the longitudinal axis of the bearing portion, is formed in the flat rail bearing surface, at a location spaced from a free end of the bearing portion of the clip, for engaging a corresponding abutment surface of the insulator to be retained on the rail bearing portion of the clip. | 07-19-2012 |
20120187203 | SEALING PLATE FOR USE WITH RAIL CLIP ANCHORING DEVICE - A sealing plate ( | 07-26-2012 |
20120187207 | RAILWAY RAIL PAD - A railway rail pad ( | 07-26-2012 |
Robert William Hamilton, London GB
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20120290669 | Zero-Click Sharing of Application Context Across Devices - A first client device performs a handoff operation to a second client device by transmitting application information, associated with a first application, to the second client device when the first client device is positioned within a predefined proximity of the second client device. The first application has a first client device user interface state when the handoff operation is performed. Further, the first client device, in response to receiving from another client device application information associated with a second application executed by the other first client device, executes a third application corresponding to the second application with an initial user interface state corresponding to a user interface state of the other client device. | 11-15-2012 |
Robin Hamilton, Renfrewshire GB
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20080317306 | Methods of and apparatus for forming a biometric image - The invention relates to a method of forming a composite biometric image. The method comprises sensing first and second successive partial images of a biometric object with a sensor during relative movement of the biometric object and the sensor. The sensor comprises an array of sensing elements defining an area smaller than an area of the biometric object to be formed as the composite biometric image and thus the first and second successive partial images overlap each other along a direction of the relative movement. The method also comprises acquiring at least a first image portion and a second image portion from each of the first and second sensed partial images, the first image portion and the second image portion of each comprising different sensed image data along a direction orthogonal to a direction of relative movement of the biometric object and the sensor, the first image portions overlapping with each other, and the second image portions overlapping with each other. The method further comprises: determining first new data of the first image portion of the second partial image absent from the first image portion of the first partial image; and determining second new data of the second image portion of the second partial image not comprised in the second image portion of the first partial image. The method concludes with the formation of the composite biometric image from the image portions in dependence upon the determined first and second new data. | 12-25-2008 |
Ronald Hamilton, Glasgow GB
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20140035176 | CONTACT LENS MANUFACTURING METHOD - In manufacturing a contact lens, a contact lens mould arrangement in which the engagement between the mould halves is unconstrained and at least one mould half is sufficiently pliable or flexible that during the curing of the contact lens composition at one mold half may move or flex relative to the other to define a post-cure mould cavity of smaller volume than the pre-cure mould cavity and during which the curvatures of the first and/or second mould surfaces are allowed to change provides a significantly more efficient manufacturing process and enables one mould half to be readily utilized as a blister cup for contact lens packaging. | 02-06-2014 |
Sheila Hamilton, Kilmacolm GB
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20100012352 | PHOTOIMAGING METHOD AND APPARATUS - There is herein described a method and apparatus for photoimaging. In particular, there is described a method and apparatus for photoimaging a substrate covered with a wet curable photopolymer, wherein the photoimaged substrate is used to form images such as electrical circuits. | 01-21-2010 |
20100015409 | PHOTOIMAGING METHOD AND APPARATUS - There is herein described a method and apparatus for photoimaging. In particular, there is described a method and apparatus for photoimaging a substrate covered with a wet curable photopolymer, wherein the photoimaged substrate is used to form images such as electrical circuits. | 01-21-2010 |
20100078042 | SURFACE CLEANING - There is herein described an improved contact cleaning surface and an improved method for cleaning surfaces. More particularly, there is described a contact cleaning surface comprising a micro-structured surface adapted to collect and/or remove microscopically sized contaminating material from a contaminated surface. | 04-01-2010 |
20120055509 | CLEANING CONTACT CLEANING ROLLERS - There is herein described an improved method for cleaning contact cleaning rollers. More particularly, there is described an improved method for cleaning contact cleaning rollers using a cleaning surface comprising lyophilic and hydrophilic microfibers. | 03-08-2012 |
20120174947 | ADHESIVE SHEETED ROLL - There is herein described an improved adhesive sheeted roll. More particularly, there is described an improved adhesive sheeted roll and individual sheets making up the sheeted roll which contain no silicones. | 07-12-2012 |
20130242510 | Photoimaging Method and Apparatus - There is herein described a method and apparatus for photoimaging. In particular, there is described a method and apparatus for photoimaging a substrate covered with a wet curable photopolymer, wherein the photoimaged substrate is used to form images such as electrical circuits. | 09-19-2013 |
Sheila Hamilton, Renfrewshire GB
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20090001674 | Fluid supply assembly for a shaft mounted device - A fluid supply assembly for a shaft mounted device, such as an oscillating roller, is disclosed having a fluid powered apparatus comprising a shaft comprising a first fluid passageway extending through a portion of the shaft and exiting at an exit point on the shaft wall; a connector arranged on the device having a bore for receiving the shaft comprising a first seal spaced apart from a second seal within the bore along an axis parallel to the shaft, the first seal, second seal, the bore and the shaft wall defining a fluid annular chamber, and a second fluid passageway leading from the fluid annular chamber to the fluid powered apparatus wherein, in use, the exit point on the shaft wall remains between the first and second seals. The fluid supply assembly allows quick release application of fluid powered rotating devices. | 01-01-2009 |
20110005550 | ADHESIVE SHEETED ROLL - There is herein described an improved adhesive sheeted roll. More particularly, there is described an improved adhesive sheeted roll and individual sheets making up the sheeted roll which contain no silicones. | 01-13-2011 |
William Dennys Ormrod Hamilton, Cambridge GB
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20100261732 | 1, 2, 4 -TRIAZOLE DERIVATIVES AS SEROTONERGIC MODULATORS - The invention relates to novel 5-hydroxytryptamine (5-HT) receptor modulator compounds of formula (I); wherein A, B, R | 10-14-2010 |
William D.o. Hamilton, Cobham GB
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20140018540 | CASEIN KINASE 1DELTA (CK 1DELTA) INHIBITORS - The invention relates to pharmaceutical compositions comprising casein kinase 1 delta (CK1δ) and to the use of said inhibitors in the treatment of neurodegenerative disorders such as Alzheimer's disease. | 01-16-2014 |
20140031547 | CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODE-GENERATIVE DISEASES SUCH AS TAUOPATHIES - The invention relates to pharmaceutical compositions comprising casein kinase 1 delta (CK1δ) and to the use of said inhibitors in the treatment of neurodegenerative disorders such as Alzheimer's disease. | 01-30-2014 |
William D.o. Hamilton, Royston GB
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20140245496 | COMPOSITIONS AND METHODS FOR THE BIOSYNTHESIS OF VANILLAN OR VANILLIN BETA-D-GLUCOSIDE - Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express a mutant AROM polypeptide and/or mutant catechol-O-methyltransferase polypeptide alone or in combination with one or more vanillin biosynthetic enzymes or UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce vanillin or vanillin beta-D-glucoside. | 08-28-2014 |
William Wright Hamilton, Fife GB
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20090301791 | SYSTEM AND METHOD FOR COUNT BY WEIGHT CORRECTION - A method and apparatus for counting nominally identical articles employs weighing apparatus, which comprises a load hod ( | 12-10-2009 |