Hirofumi Noguchi
Hirofumi Noguchi, Kanagawa-Ken JP
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20090065417 | SOLID-LIQUID SEPARATOR - A solid-liquid separator that separates raw water containing suspended solids into suspended solids (solid) and treated water (liquid) in easy and a short time is provided. A solid-liquid separator includes a separation tub, an inflow pipe configured to rotate raw water which flowed from the outlet of the inflow pipe in the separation tub, a froth discharge pipe configured to discharge the suspended solids surfaced in the separation tub and a treated water discharge pipe configured to discharge treated water by which the suspended solids were removed from raw water from the separation tub. | 03-12-2009 |
20120187040 | SOLID-LIQUID SEPARATOR - A solid-liquid separator that separates raw water containing suspended solids into suspended solids (solid) and treated water (liquid) in easy and a short time is provided. A solid-liquid separator includes a separation tub, an inflow pipe configured to rotate raw water which flowed from the outlet of the inflow pipe in the separation tub, a froth discharge pipe configured to discharge the suspended solids surfaced in the separation tub and a treated water discharge pipe configured to discharge treated water by which the suspended solids were removed from raw water from the separation tub. | 07-26-2012 |
Hirofumi Noguchi, Dallas, TX US
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20110182979 | In-Vivo Non-Viral Gene Delivery of Human Vascular Endothelial Growth Factor Following Islet Transplantation - An ultrasound-mediated gene transfer method named Ultrasound Targeted Microbubble Destruction (UTMD) for the delivery of human vascular endothelial growth factor (hVEGF) gene to transplanted islets and the surrounding tissue is described herein. The delivery of hVEGF promotes islet revascularization and survival. The inventors, first transplanted human islets were transplanted into diabetic nude mice liver followed by the induction of non-viral plasmid vectors encoding hVEGF or Green Fluorescent Protein (GFP) gene in the host liver by UTMD. Transplantation without gene delivery was also performed as a control. Blood glucose, serum human insulin, C-peptide levels and the revascularization in graft islets were evaluated. The findings of the method of the present invention indicated that hVEGF gene delivery to host liver using UTMD promoted islet revascularization after islet transplantation and improved the restoration of euglycemia. | 07-28-2011 |
Hirofumi Noguchi, Kitu-Ku JP
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20120009244 | NEUROD1 GENE EXPRESSION IN NON-ENDOCRINE PANCREATIC EPITHELIAL CELLS (NEPECs) - The introduction of the human NeuroD1 gene into human non-endocrine pancreatic epithelial cells (NEPECs) for producing insulin producing cells in vitro is described herein. Cytokeratin19 (CK19) positive NEPECs were transfected with plasmids encoding human NeuroD1 gene under human CK19 promoter. On characterization following the induction it was found that NEPEC+ND strongly expressed NeuroD1 and insulin mRNA. The ratio of NeuroD1 and human insulin positive cells in NEPEC+ND was significantly higher than NEPEC. Human insulin and C-peptide levels in culture media in NEPEC+ND were significantly higher than NEPEC. The findings demonstrate that human NeuroD1 under control of the CK19 promoter induces the differentiation of CK19 positive NEPECs into insulin producing cells. | 01-12-2012 |
Hirofumi Noguchi, Okayama JP
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20120135015 | Induction of Pancreatic Stem Cells by Transient Overexpression of Reprogramming Factors and PDX1 Selection - Methods for generating pancreatic stem cells from a pancreatic tissue of 24-week old mice by transient overexpression of reprogramming factors combined with Pdx1 selection is described herein. The generated cells were designated as iPaS (induced pancreatic stem) cells and exhibit the same morphology as the pancreatic stem cells previously established from young donors without genetic manipulation and express genetic markers of endoderm and pancreatic progenitors. Transplantation of the iPaS cells into nude mice resulted in no teratoma formation. Moreover, iPaS cells were able to differentiate into insulin-producing cells more efficiently than ES cells. In addition, the technology of transient overexpression of reprogramming factors and tissue-specific selection of the present invention may also be useful for the generation of other tissue-specific stem cells. | 05-31-2012 |
Hirofumi Noguchi, Sakai-Shi JP
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20120234767 | COPPER RECOVERY APPARATUS AND COPPER RECOVERY METHOD - According to one embodiment, a copper recovery apparatus includes a precipitation tank configured to precipitate copper hydroxide grains in water, a filter aid supplyer, a mixing tank configured to mix the filter aid with a water to produce a suspension, a separator provided with a filter, a line configured to supply the suspension to the separator, thereby forming a precoat layer formed of the filter aid on the filter, a separation tank configured to receive the detached matter of the precoat layer discharged together with the detaching water from the separator to magnetically separate copper hydroxide grains and filter aid, a line configure to discharge and recover the detaching water from the separation tank, and a line configured to return the separated filter aid to the filter aid supplyer from the separation tank. | 09-20-2012 |
20120234768 | RESIN COMPOSITE, FILTER AID FOR WATER TREATMENT, PRECOAT MATERIAL FOR WATER TREATMENT, AND WATER TREATMENT METHOD - According to one embodiment, a magnetic material coated resin includes an aggregate obtainable by aggregation of primary particles includes magnetic particles of which surfaces are coated with a polymer. The primary particles have an average diameter D | 09-20-2012 |
20120312727 | COPPER RECOVERY APPARATUS - According to one embodiment, a copper recovery apparatus includes a precipitation tank, a mixing tank, a filter-aid feeder, a solid-liquid separator includes a filter, a cleaning-water supply line, a cleaning-water discharge line, a separation tank, and a filter-aid return line. The precipitation tank is configured to receive copper ions-containing water to be treated and an alkali to prepare treated water containing a precipitate of copper compound. The solid-liquid separator is configured to allow the treated water to be passed through the filter on which the precoat layer is deposited to separate the precipitate retained on the precoat layer from a filtrate. | 12-13-2012 |
20140284256 | COPPER RECOVERY APPARATUS - According to one embodiment, a copper recovery apparatus includes a precipitation tank, a mixing tank, a filter-aid feeder, a solid-liquid separator includes a filter, a cleaning-water supply line, a cleaning-water discharge line, a separation tank, and a filter-aid return line. The precipitation tank is configured to receive copper ions-containing water to be treated and an alkali to prepare treated water containing a precipitate of copper compound. The solid-liquid separator is configured to allow the treated water to be passed through the filter on which the precoat layer is deposited to separate the precipitate retained on the precoat layer from a filtrate. | 09-25-2014 |
20140377152 | COPPER RECOVERY APPARATUS AND COPPER RECOVERY METHOD - According to one embodiment, a copper recovery apparatus includes a precipitation tank configured to precipitate copper hydroxide grains in water, a filter aid supplier, a mixing tank configured to mix the filter aid with a water to produce a suspension, a separator provided with a filter, a line configured to supply the suspension to the separator, thereby forming a precoat layer formed of the filter aid on the filter, a separation tank configured to receive the detached matter of the precoat layer discharged together with the detaching water from the separator to magnetically separate copper hydroxide grains and filter aid, a line configure to discharge and recover the detaching water from the separation tank, and a line configured to return the separated filter aid to the filter aid supplier from the separation tank. | 12-25-2014 |
Hirofumi Noguchi, Kyoto-Shi JP
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20130017606 | METHOD OF SEPARATING PANCREATIC ISLET - The present invention provides a pancreatic islet isolation method comprising the steps of (1) injecting a protection solution containing a protease inhibitor into the pancreatic duct of an procured pancreas; (3) digesting the pancreas into which the protection solution has been injected; and (4) purifying the digested pancreatic tissue using a purification solution containing a density gradient reagent. The present invention also provides a protection solution for injection into the pancreatic duct, a pancreas preservation solution for the two-layer method, and an islet purification solution. | 01-17-2013 |