Qiu, US
Bo-Xing Qiu, Chesterfield, MO US
Patent application number | Description | Published |
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20090081353 | CORN PLANTS AND SEED ENHANCED FOR ASPARAGINE AND PROTEIN - The present invention relates to a corn plant and seed with enhanced levels of protein and amino acids. The invention also relates to DNA constructs that provide expression in transgenic corn cells of an asparagine synthetase enzyme. The DNA constructs are used in a method to produce transgenic corn plants and seeds and to select for plants and seeds with enhanced levels of protein and amino acids. | 03-26-2009 |
20110020526 | CORN PLANTS AND SEED ENHANCED FOR ASPARAGINE AND PROTEIN - The present invention relates to a corn plant and seed with enhanced levels of protein and amino acids. The invention also relates to DNA constructs that provide expression in transgenic corn cells of an asparagine synthetase enzyme. The DNA constructs are used in a method to produce transgenic corn plants and seeds and to select for plants and seeds with enhanced levels of protein and amino acids. | 01-27-2011 |
20110214205 | Isolated Novel Nucleic Acid and Protein Molecules from Foxtail Millet and Methods of Using Those Molecules to Generate Transgenic Plants with Enhanced Agronomic Traits - This disclosure provides purified nucleic acids and polypeptides and various uses of these sequences. Also provided are transgenic plants, seeds, and plant cells containing DNA for expression of the proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants, methods of making such plants and methods of making agricultural commodity including seeds and hybrid seeds from such plants. | 09-01-2011 |
20110293815 | CORN PLANTS AND SEED ENHANCED FOR ASPARAGINE AND PROTEIN - The present invention relates to a corn plant and seed with enhanced levels of protein and amino acids. The invention also relates to DNA constructs that provide expression in transgenic corn cells of an asparagine synthetase enzyme. The DNA constructs are used in a method to produce transgenic corn plants and seeds and to select for plants and seeds with enhanced levels of protein and amino acids. | 12-01-2011 |
20120017292 | ISOLATED NOVEL NUCLEIC ACID AND PROTEIN MOLECULES FROM CORN AND METHODS OF USING THOSE MOLECULES TO GENERATE TRANSGENE PLANTS WITH ENHANCED AGRONOMIC TRAITS - This disclosure provides purified nucleic acids and polypeptides. Also provided are transgenic plants, seeds, and plant cells containing DNA for expression of the proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants, methods of making such plants and methods of making agricultural commodity including seeds and hybrid seeds from such plants. | 01-19-2012 |
20120017338 | ISOLATED NOVEL NUCLEIC ACID AND PROTEIN MOLECULES FROM CORN AND METHODS OF USING THOSE MOLECULES TO GENERATE TRANSGENIC PLANT WITH ENHANCED AGRONOMIC TRAITS - This disclosure provides purified nucleic acids and polypeptides. Also provided are transgenic plants, seeds, and plant cells containing DNA for expression of the proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants, methods of making such plants and methods of making agricultural commodity including seeds and hybrid seeds from such plants. | 01-19-2012 |
20120117685 | Isolated Novel Nucleic Acid and Protein Molecules from Soybeans and Methods of Using Thos Molecules - This disclosure provides purified nucleic acids and polypeptides and various uses of these sequences such as transcript profiling. Also provided are transgenic plants, seeds, and plant cells containing DNA for expression of the proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants, methods of making such plants and methods of making agricultural commodity including seeds and hybrid seeds from such plants. | 05-10-2012 |
20120246748 | ISOLATED NOVEL ACID AND PROTEIN MOLECULES FROM SOY AND METHODS OF USING THOSE MOLECULES TO GENERATE TRANSGENE PLANTS WITH ENHANCED AGRONOMIC TRAITS - This disclosure provides purified nucleic acids and polypeptides. Also provided are transgenic plants, seeds, and plant cells containing DNA for expression of the proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants, methods of making such plants and methods of making agricultural commodity including seeds and hybrid seeds from such plants. | 09-27-2012 |
20130031672 | PLANT REGULATORY ELEMENTS AND USES THEREOF - The invention provides DNA molecules and constructs, and their nucleotide sequences, useful for modulating gene expression in plants, and for specifying intracellular or extracellular localization of a gene product of interest. Transgenic plants, plant cells, plant parts, and seeds, comprising the DNA molecules operably linked to heterologous transcribable polynucleotides are also provided. | 01-31-2013 |
20140165234 | ISOLATED NOVEL NUCLEIC ACID AND PROTEIN MOLECULES FROM FOXTAIL MILLET AND METHODS OF USING THOSE MOLECULES TO GENERATE TRANSGENIC PLANTS WITH ENHANCED AGRONOMIC TRAITS - This disclosure provides purified nucleic acids and polypeptides and various uses of these sequences. Also provided are transgenic plants, seeds, and plant cells containing DNA for expression of the proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants, methods of making such plants and methods of making agricultural commodity including seeds and hybrid seeds from such plants. | 06-12-2014 |
20140359836 | Isolated Novel Nucleic Acid and Protein Molecules from Corn and Methods of Using those Molecules to Generate Transgenic Plant with Enhanced Agronomic Traits - This disclosure provides purified nucleic acids and polypeptides. Also provided are transgenic plants, seeds, and plant cells containing DNA for expression of the proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants, methods of making such plants and methods of making agricultural commodity including seeds and hybrid seeds from such plants. | 12-04-2014 |
Bo-Xing Qiu, Chesterfiel, MO US
Patent application number | Description | Published |
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20120023611 | Isolated Novel Nucleic Acid and Protein Molecules from Corn and Methods of Using Thereof - This disclosure provides purified nucleic acids and polypeptides and various uses of these sequences such as transcript profiling. Also provided are transgenic plants, seeds, and plant cells containing DNA for expression of the proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants, methods of making such plants and methods of making agricultural commodity including seeds and hybrid seeds from such plants. | 01-26-2012 |
20120210458 | Isolated Novel Nucleic Acid and Protein Molecules from Corn and Methods of Using Thereof - This disclosure provides purified nucleic acids and polypeptides and various uses of these sequences such as transcript profiling. Also provided are transgenic plants, seeds, and plant cells containing DNA for expression of the proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants, methods of making such plants and methods of making agricultural commodity including seeds and hybrid seeds from such plants. | 08-16-2012 |
Bo-Xing Qiu, Chesterfiled, MO US
Patent application number | Description | Published |
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20130333061 | ISOLATED NOVEL NUCLEIC ACID AND PROTEIN MOLECULES FROM SOY AND METHODS OF USING THOSE MOLECULES TO GENERATE TRANSGENIC PLANTS WITH ENHANCED AGRONOMIC TRAITS - This disclosure provides purified nucleic acids and polypeptides. Also provided are transgenic plants, seeds, and plant cells containing DNA for expression of the proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants, methods of making such plants and methods of making agricultural commodity including seeds and hybrid seeds from such plants. | 12-12-2013 |
Dawn Qiu, Saint Paul, MN US
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20120234460 | OLED LIGHT EXTRACTION FILMS HAVING NANOPARTICLES AND PERIODIC STRUCTURES - A light extraction film having nanoparticles with engineered periodic structures. The light extraction film includes a substantially transparent substrate, low index one-dimensional or two-dimensional periodic structures on the substrate, and a high index planarizing backfill layer applied over the periodic structures. Light scattering nanoparticles are either applied in a layer over the periodic structures or included in the backfill layer. | 09-20-2012 |
Dongming Qiu, Dublin, OH US
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20090004074 | Hydrogen peroxide production in microchannel reactors - The present invention includes methods and apparatuses that utilize microchannel technology and, more specifically in exemplary form, producing hydrogen peroxide using microchannel technology. An exemplary process for producing hydrogen peroxide comprises flowing feed streams into intimate fluid communication with one another within a process microchannel to form a reactant mixture stream comprising a hydrogen source and an oxygen source such as, without limitation, hydrogen gas and oxygen gas. Thereafter, a catalyst is contacted by the reactant mixture and is operative to convert a majority of the reactant mixture to hydrogen peroxide that is withdrawn via an egressing product stream. During the hydrogen peroxide chemical reaction, exothermic energy is generated. This exothermic energy is absorbed by the fluid within the microchannel as well as the microchannel itself. In a preferred embodiment, a heat exchange fluid is in thermal communication with the microchannel housing the exothermic reaction and is operative to absorb a portion of this exothermic energy and transfer such energy from the microchannel. | 01-01-2009 |
20090043141 | Oxidative coupling of methane - A microchannel apparatus comprising a conduit including a microchannel mixing section, a microchannel reaction section, a microchannel heat transfer section, and a separation section, where the microchannel mixing section includes direct injection inlets, where the microchannel mixing section is downstream from the reaction section, and where the separation section is downstream from the reaction section. Further exemplary embodiments are also disclosed. | 02-12-2009 |
20090074627 | MANIFOLD DESIGNS, AND FLOW CONTROL IN MULITCHANNEL MICROCHANNEL DEVICES - Novel manifolds and methods of flow through manifolds are described. Apparatus and techniques are described in which flow from a relatively large volume header is equally distributed to process channels. Methods of making laminated, microchannel devices are also described. | 03-19-2009 |
20100300550 | Multi-Stream Microchannel Device - Provided is a process and device for exchanging heat energy between three or more streams in a microchannel heat exchanger which can be integrated with a microchannel reactor to form an integrated microchannel processing unit. The combining of a plurality of integrated microchannel devices to provide the benefits of large-scale operation is enabled. In particular, the microchannel heat exchanger enables flexible heat transfer between multiple streams and total heat transfer rates of about 1 Watt or more per core unit volume expressed as W/cc. | 12-02-2010 |
20110002818 | MICROCHANNEL WITH INTERNAL FIN SUPPORT FOR CATALYST OR SORPTION MEDIUM - This invention relates to an apparatus, comprising: at least one process microchannel having a height, width and length, the height being up to about 10 mm, the process microchannel having a base wall extending in one direction along the width of the process microchannel and in another direction along the length of the process microchannel; at least one fin projecting into the process microchannel from the base wall and extending along at least part of the length of the process microchannel; and a catalyst or sorption medium supported by the fin. | 01-06-2011 |
20110300039 | Integrated Combustion Reactors And Methods Of Conducting Simultaneous Endothermic and Exothermic Reactions - Integrated Combustion Reactors (ICRs) and methods of making ICRs are described in which combustion chambers (or channels) are in direct thermal contact to reaction chambers for an endothermic reaction. Particular reactor designs are also described. Processes of conducting reactions in integrated combustion reactors are described and results presented. Some of these processes are characterized by unexpected and superior results, and/or results that can not be achieved with any prior art devices. | 12-08-2011 |
20130186607 | Multi-Stream Microchannel Device - Provided is a process and device for exchanging heat energy between three or more streams in a microchannel heat exchanger which can be integrated with a microchannel reactor to form an integrated microchannel processing unit. The combining of a plurality of integrated microchannel devices to provide the benefits of large-scale operation is enabled. In particular, the microchannel heat exchanger enables flexible heat transfer between multiple streams and total heat transfer rates of about 1 Watt or more per core unit volume expressed as W/cc. | 07-25-2013 |
20140246625 | Integrated Combustion Reactor And Methods Of Conducting Simultaneous Endothermic and Exothermic Reactions - Integrated Combustion Reactors (ICRs) and methods of making ICRs are described in which combustion chambers (or channels) are in direct thermal contact to reaction chambers for an endothermic reaction. Particular reactor designs are also described. Processes of conducting reactions in integrated combustion reactors are described and results presented. Some of these processes are characterized by unexpected and superior results, and/or results that can not be achieved with any prior art devices. | 09-04-2014 |
20140332081 | MANIFOLD DESIGNS, AND FLOW CONTROL IN MULTICHANNEL MICROCHANNEL DEVICES - Novel manifolds and methods of flow through manifolds are described. Apparatus and techniques are described in which flow from a relatively large volume header is equally distributed to process channels. Methods of making laminated, microchannel devices are also described. | 11-13-2014 |
Dongru Qiu, Huntington, WV US
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20110008786 | METHODS OF DETECTING AND CONTROLLING MUCOID PSEUDOMONAS BIOFILM PRODUCTION - Compositions and methods for detecting and controlling the conversion to mucoidy in | 01-13-2011 |
Dongru Qiu, Norman, OK US
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20110184157 | Methods of Producing Bacterial Alginates - Methods for mass producing bacterial alginate, bacterial cultures for producing alginate, and pharmaceutical compositions containing bacterial alginate are contemplated. | 07-28-2011 |
Duyu Qiu US
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20120154452 | METHOD FOR QUICKLY ADJUSTING THE WAVEFORM BRIGHTNESS OF DIGITAL THREE-DIMENSIONAL OSCILLOSCOPE - The present invention provides a method for quickly adjusting the waveform brightness of digital three-dimensional (3D) oscilloscope, creates a ROM in FPGA and take it as a look-up table of screen display brightness value of LCD that is corresponding to the waveform occurrence N(T, A) at the current brightness gradation L, and divide the ROM into 2 | 06-21-2012 |
Feng Qiu, Doylestown, PA US
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20110118354 | CYCLOHEXENYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY - The present application describes modulators of MCP-1 or CCR-2 of formula, (I) or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein T, W, X, Y, Z, R | 05-19-2011 |
Fenghe Qiu, New Milford, CT US
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20140037719 | STABILIZED PHARMACEUTICAL FORMULATIONS OF A POTENT HCV INHIBITOR - Described are various methods for stabilizing pharmaceutical formulations of a specific Hepatitis C Viral (HCV) inhibitor against the formation of a particular genotoxic degradation product. Such methods include temperature control, moisture control, excipient control, capsule shell control, basification and a reconstitution approach. | 02-06-2014 |
Heng Qiu US
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20130062641 | LED LAMP - A LED lamp is disclosed which has a plurality of light unit, each of the light unit has at least one flat metal lead for heat dissipation and the lower part of the metal lead is mounted on a heat sink for a further heat dissipation. | 03-14-2013 |
Hongjin Qiu, Evanston, IL US
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20120225972 | Poly (Diol Co-Citrate) Hydroxyapatite Composite for Tissue Engineering and Orthapaedic Fixation Devices - The present invention is directed to a novel poly (diol citrates)-based bioceramic composite materials created using completely biodegradable and a bioceramic material polymers that may be used in implantable devices. More specifically, the specification describes methods and compositions for making and using bioceramic composites comprised of citric acid copolymers and a bioceramic material. | 09-06-2012 |
20140155516 | POLY (DIOL CO-CITRATE) HYDROXYAPATITE COMPOSITE FOR TISSUE ENGINEERING AND ORTHOPAEDIC FIXATION DEVICES - The present invention is directed to a novel poly(diol citrates)-based bioceramic composite materials created using completely biodegradable and a bioceramic material polymers that may be used in implantable devices. More specifically, the specification describes methods and compositions for making and using bioceramic composites comprised of citric acid copolymers and a bioceramic material. | 06-05-2014 |
Jake Yongjian Qiu, Greenville, SC US
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20100265634 | HIGH VOLTAGE AND HIGH EFFICIENCY POLYMER ELECTROLYTIC CAPACITORS - A capacitor, and method of making a capacitor, is provided wherein the capacitor has exceptionally high break down voltage. The capacitor has a tantalum anode with an anode wire attached there to. A dielectric film is on the tantalum anode. A conductive polymer is on the dielectric film. An anode lead is in electrical contact with the anode wire. A cathode lead is in electrical contact with the conductive polymer and the capacitor has a break down voltage of at least 60 V. | 10-21-2010 |
20110252613 | HIGH VOLTAGE AND HIGH EFFICIENCY POLYMER ELECTROLYTIC CAPACITORS - A capacitor, and method of making a capacitor, is provided wherein the capacitor has exceptionally high break down voltage. The capacitor has a tantalum anode with an anode wire attached there to. A dielectric film is on the tantalum anode. A conductive polymer is on the dielectric film. An anode lead is in electrical contact with the anode wire. A cathode lead is in electrical contact with the conductive polymer and the capacitor has a break down voltage of at least 60 V. | 10-20-2011 |
James Qiu US
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20130179144 | PERFORMANCE BOTTLENECK DETECTION IN SCALABILITY TESTING - A testing system can perform scalability testing on a target system, including automatically identifying a performance bottleneck component of the target system when the target system includes multiple components. The testing system can specify a target load of a specified component of the target system. The testing system can provide a simulated request to the target system and measure performance of the target system. Based on the measurement, the testing system can determine a scaling factor. The testing system can scale up the simulated request by the scaling factor, and determine whether one or more components of the target system have reached full capacity. The testing system can then adjust the scaling factor and the simulated request, until the testing system identifies a component of the target system that is a performance bottleneck of the target system when a specific number of requests are provided. | 07-11-2013 |
20130179401 | Checkpoint Based Progressive Backup - Methods, program products, and systems for checkpoint based progressive backup are described. When a system receives a request to update a page of a storage device storing database files of a database, the system can update the page and replicate the updated page in a shadow page in a backup queue. The backup queue can store multiple shadow pages, where each updated page can correspond to at most a specified number of shadow pages in the queue. Each shadow page can be associated with a timestamp of a latest update. At pre-specified temporal checkpoints, the system can write the shadow pages in the queue to a backup file in the order of the timestamps. Upon receiving a restoration request, the system can restore the database to a state as of the time of the checkpoint using the backup file. | 07-11-2013 |
Jian Qiu, Portland, OR US
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20080214609 | Development of new selective estrogen receptor modulators - The present disclosure concerns a new class of selective estrogen receptor modulators (SERMs). The disclosure also includes the identification of a previously unknown membrane associated estrogen receptor. Methods for making and using the disclosed SERMs are disclosed, including pharmaceutical formulations of the disclosed novel compounds in useful compositions. | 09-04-2008 |
20110152226 | Development of New Selective Estrogen Receptor Modulators - The present disclosure concerns a new class of selective estrogen receptor modulators (SERMs). The disclosure also includes the identification of a previously unknown membrane associated estrogen receptor. Methods for making and using the disclosed SERMs are disclosed, including pharmaceutical formulations of the disclosed novel compounds in useful compositions. | 06-23-2011 |
Jian Qiu, Longmont, CO US
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20090054667 | Transition metal catalyzed cross-coupling of 1-halo-1-haloalkene compounds - Methods for introducing a 1-halo-1-haloalkene compound onto an aromatic or heteroaromatic ring are provided, including processes for the production of certain 1-halovinyl aryl or heteroaryl derivatives in which the 1-halovinyl group is either 1-fluoro or 1-chlorovinyl and the aromatic species phenyl or thiophene, the processes including coupling an arylmagnesium species with a dihalo olefin in the presence of a nickel or iron catalyst. | 02-26-2009 |
20100286169 | Antibacterial Sulfone and Sulfoxide Substituted Heterocyclic Urea Compounds - The present invention provides novel sulfone and sulfoxide substituted heterocyclic urea compounds having useful antibacterial activity. Use of these compounds as pharmaceutical compositions and methods of production are provided. | 11-11-2010 |
20110136875 | Pyrrole Inhibitors of S-Nitrosoglutathione Reductase - The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same. | 06-09-2011 |
20110136881 | Novel Pyrrole Inhibitors of S-Nitrosoglutathione Reductase as Therapeutic Agents - The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same. | 06-09-2011 |
20110144110 | Novel Pyrrole Inhibitors of S-Nitrosoglutathione Reductase as Therapeutic Agents - The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same. | 06-16-2011 |
20110144180 | Novel Pyrrole Inhibitors of S-Nitrosoglutathione Reductase as Therapeutic Agents - The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same. | 06-16-2011 |
20120015941 | Antibacterial Amide and Sulfonamide Substituted Heterocyclic Urea Compounds - The present invention provides novel amide and sulfonamide substituted heterocyclic urea compounds having useful antibacterial activity. Use of these compounds as pharmaceutical compositions and method of their production are also provided. | 01-19-2012 |
20120208817 | Novel Dihydropyrimidin-2(1H)-one Compounds as S-Nitrosoglutathione Reductase Inhibitors - The present invention is directed to novel dihydropyrimidin-2(1H)-one compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same. | 08-16-2012 |
20120289555 | Novel S-Nitrosoglutathione Reductase Inhibitors - The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same. | 11-15-2012 |
20120295966 | Chromone Inhibitors of S-Nitrosoglutathione Reductase - The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same. | 11-22-2012 |
20130096161 | Novel Dihydropyridin-2(1H)-One Compounds as S-Nitrosoglutathione Reductase Inhibitors and Neurokinin-3 Receptor Antagonists - The present invention is directed to novel dihydropyridin-2(1H)-one compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors and/or Neurokinin-3 (NK3) receptor antagonists, pharmaceutical compositions comprising such compounds, and methods of making and using the same. | 04-18-2013 |
20130131093 | Novel Dihydropyrimidin-2(1H)-One Compounds As Neurokinin-3 Receptor Antagonists - The present invention is directed to novel dihydropyrimidin-2(1H)-one compounds useful as Neurokinin-3 (NK3) receptor antagonists, pharmaceutical compositions comprising such compounds, and methods of making and using the same. | 05-23-2013 |
20130178499 | Novel Substituted Quinoline Compounds as S-Nitrosoglutathione Reductase Inhibitors - The present invention is directed to novel quinoline compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same. | 07-11-2013 |
20130253024 | Novel Pyrrole Inhibitors of S-Nitrosoglutathione Reductase as Therapeutic Agents - The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same. | 09-26-2013 |
20130261122 | Novel Substituted Bicyclic Aromatic Compounds as S-Nitrosoglutathione Reductase Inhibitors - The present invention is directed to novel substituted bicyclic aromatic compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same. | 10-03-2013 |
20130261123 | Novel Substituted Bicyclic Aromatic Compounds as S-Nitrosoglutathione Reductase Inhibitors - The present invention is directed to novel substituted bicyclic aromatic compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same. | 10-03-2013 |
20130274320 | Chromone Inhibitors of S-Nitrosoglutathione Reductase - The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same. | 10-17-2013 |
20140094465 | Compounds as S-Nitrosoglutathione Reductase Inhibitors - The present invention is directed to compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same. | 04-03-2014 |
20140113938 | Pyrrole Inhibitors of S-Nitrosoglutathione Reductase - The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same. | 04-24-2014 |
20140155447 | Novel Pyrrole Inhibitors of S-Nitrosoglutathione Reductase as Therapeutic Agents - The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same. | 06-05-2014 |
20140163092 | Chromone Inhibitors of S-Nitrosoglutathione Reductase - The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same. | 06-12-2014 |
20140194425 | Novel Pyrrole Inhibitors of S-Nitrosoglutathione Reductase as Therapeutic Agents - The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same. | 07-10-2014 |
20140194481 | Novel Pyrrole Inhibitors of S-Nitrosoglutathione Reductase as Therapeutic Agents - The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same. | 07-10-2014 |
20140235640 | Novel Dihydropyrimidin-2(1H)-one Compounds as S-Nitrosoglutathione Reductase Inhibitors - The present invention is directed to novel dihydropyrimidin-2(1H)-one compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same. | 08-21-2014 |
20140275185 | Novel S-Nitrosoglutathione Reductase Inhibitors - The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same. | 09-18-2014 |
20140329821 | Novel Substituted Bicyclic Aromatic Compounds as S-Nitrosoglutathione Reductase Inhibitors - The present invention is directed to novel substituted bicyclic aromatic compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same. | 11-06-2014 |
20150080429 | Novel Substituted Quinoline Compounds as S-Nitrosoglutathione Reductase Inhibitors - The present invention is directed to novel quinoline compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same. | 03-19-2015 |
Jijun Qiu, Norman, OK US
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20140252529 | Pb-salt Mid-infrared Detectors and Method for Making Same - The disclosure describes methods for preparing lead salt materials which are sensitive to the mid-infrared spectrum which can be used to manufacture high-uniformity, high-detectivity, polycrystalline lead salt photoconductive and photovoltaic photodetectors. | 09-11-2014 |
Joe Zhaoyao Qiu, Baton Rouge, LA US
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20110021700 | EXTRUSION PROCESS FOR GRAFTING RUBBERS - The invention relates to a process for producing a grafted rubber comprising: a) providing an ethylene propylene rubber having a weight average molecular weight (Mw) of at least 80 kg/mol in a continuous extrusion reactor by feeding the rubber in a slab/melt dosing unit and transporting the rubber to the continuous extrusion reactor by a melt pump; b) drying the rubber in the continuous extrusion reactor to a moisture content of between about 0.2 and about 0.5 wt %; c) providing the dried rubber to a first injection zone of the continuous extrusion reactor at a temperature of between 190 and 250° C., d) in the first injection zone, providing successively a first amount of maleic anhydride and a first free-radical initiator to the dried rubber; e) reacting maleic anhydride with the rubber in a first reaction zone of the continuous extrusion reactor to produce a grafted rubber; f) in a second injection zone, providing successively a second amount of maleic anhydride and a second free-radical initiator, the first and the second free radical initiator is an organic peroxide with a half-life (ty2) of more than 1 second if measured in mono-chlorobenzene at 220° C. g) applying shear to the grafted rubber in a second reaction zone of the continuous extrusion reactor, the shear sufficient to reduce the weight average molecular weight (Mw) of the grafted rubber by a factor of at least 2. | 01-27-2011 |
Judy Qiu, Baltimore, MD US
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20100034864 | STEM CELL CAPTURE AND IMMOBILIZATION COATINGS FOR MEDICAL DEVICES AND IMPLANTS - Constructs and methods for immobilizing stem and other precursor cells, as well as other bioactive materials of therapeutic value on the surfaces of medical devices, such as bone, cartilage, spinal and tooth implants, are described herein. The present invention has broad application in the incorporation of bioactive and therapeutic materials in or on a medical implant or other interventional device, having particular value in enabling the real-time, utilization by medical personnel of bioactive materials extracted from the patient and subsequently reintroduced and immobilized in an implant device. | 02-11-2010 |
20120270294 | STEM CELL CAPTURE AND IMMOBILIZATION COATINGS FOR MEDICAL DEVICES AND IMPLANTS - Constructs and methods for immobilizing stem and other precursor cells, as well as other bioactive materials of therapeutic value on the surfaces of medical devices, such as bone, cartilage, spinal and tooth implants, are described herein. The present invention has broad application in the incorporation of bioactive and therapeutic materials in or on a medical implant or other interventional device, having particular value in enabling the real-time, utilization by medical personnel of bioactive materials extracted from the patient and subsequently reintroduced and immobilized in an implant device. | 10-25-2012 |
Junhai Qiu, Beaverton, OR US
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20090087162 | Method and apparatus for media playback - In one embodiment of the invention, a memory may receive digital video data containing a first I frame and a second I frame with a plurality of P frames located between the I frames. The I frames each include a first timestamp. A processor may determine a subset of the P frames to be played in a trick mode along with the first I frame and the second I frame based on the number of P frames included in the plurality of P frames and the desired playback speed. | 04-02-2009 |
Li Qiu, West Lafayette, IN US
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20090062275 | N-Substituted Imidazopyridine c-Kit Inhibitors - Compounds represented by Formula (I): | 03-05-2009 |
Liangheng Qiu, Waukesha, WI US
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20080279336 | METHOD FOR COATING A CARBON-CARBON COMPOSITE X-RAY TUBE BEARING CAGE - A method for manufacturing an x-ray tube bearing cage includes the step of forming a bearing cage from a carbon-carbon composite material. A coating is applied to the carbon-carbon composite bearing cage. The coating includes an outer layer formed of a dry film lubricant. The coated carbon-carbon composite bearing cage is included in a bearing assembly in the x-ray tube and forms a lubricious enclosure for bearing balls positioned therein to minimize wear and heat generation in the bearing assembly. | 11-13-2008 |
20100128848 | X-RAY TUBE HAVING LIQUID LUBRICATED BEARINGS AND LIQUID COOLED TARGET - An x-ray tube having a liquid lubricated bearing assembly and a liquid cooled anode target. The anode target and bearing assembly having increased lubrication and cooling to withstand higher power, higher temperature and higher load applications. | 05-27-2010 |
Liangheng Qiu, Lake In The Hills, IL US
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20140035409 | BALL BEARING PARTICULARLY FOR USE IN HIGH SPEED GENERATOR - A ball bearing has an outer race and an inner race A plurality of ball members are supported radially between the inner and outer races. A pair of bearing cage halves are placed at axial ends of the balls. The bearing cage halves are formed of a first relatively hard material, and have a plating of a softer material on some surfaces The bearing cage halves have pockets facing the balls and with the soft plating The bearing cage halves are riveted together along a contact surface, not including the soft plating. The rivets extend through an aperture in each of the bearing cage halves, not provided with the soft plating. The rivets have heads extending into a ditch, not provided with the soft plating. A rotor sub-assembly, a generator, and a method of maintaining a generator are also disclosed. | 02-06-2014 |
20140219598 | VARIABLE FREQUENCY GENERATOR INPUT SHAFT BEARING - A ball bearing assembly comprises an inner race configured to support an input shaft extending through a center axis of the ball bearing assembly, and an outer race configured to couple to a bearing support fixture. A bearing cage is disposed between the inner and outer races, the bearing cage having a plurality of apertures spaced apart from one another by a predetermined distance. The ball bearing assembly further includes a plurality of ball elements, each ball element disposed in a respective aperture to define an internal radial clearance that is maintained in response to a misalignment of the input shaft. | 08-07-2014 |
Liangheng Qiu, Brookfield, WI US
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20080279335 | CAGE FOR X-RAY TUBE BEARINGS - A bearing assembly mounted in an x-ray tube includes a bearing race and a plurality of bearing balls positioned adjacent to the bearing race. The plurality of bearing balls are positioned within a bearing cage. The bearing cage is configured to evenly space the bearing balls within the bearing cage and prevent contact between adjacent bearing balls, thereby eliminating the problems of skidding wear and dynamic impact load between adjacent bearing balls in the bearing assembly. | 11-13-2008 |
Mengsheng Qiu, Louisville, KY US
Patent application number | Description | Published |
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20110280846 | OLFACTORY EPITHELIAL-DERIVED STEM CELLS AND METHODS OF USE THEREFOR - The presently disclosed subject matter provides recombinant dopaminergic neurons and/or recombinant progenitors thereof that include one or more transgenes encoding a nurr-1 polypeptide, a pitx3 polypeptide, an Imxi a polypeptide, a biologically active fragment thereof, a biologically active derivative thereof, and/or any combination thereof. Also provided are methods for producing a recombinant dopaminergic neuron or recombinant progenitor thereof, methods for producing lineage primed cells, methods for ameliorating at least one symptom associated with a neurological disorder, methods for transplantation, methods for inducing growth, repair, and/or regeneration of a neuron, for delivering a cytokine or a growth factor to the central nervous system, methods for providing a dopaminergic neuron function, and cell cultures that include recombinant olfactory epithelial-derived stem cells and/or a differentiated derivatives thereof. | 11-17-2011 |
Minglun Qiu, Bloomfield, CT US
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20100089707 | PERMANENT MAGNET NOISE ISOLATOR - An elevator system ( | 04-15-2010 |
20100309452 | METHODS AND DEVICES FOR SURVEYING ELEVATOR HOISTWAYS - A device for surveying an enclosed structure ( | 12-09-2010 |
20110056770 | UNDERSLUNG ELEVATOR CAR CONFIGURATION - An exemplary elevator system includes an elevator car ( | 03-10-2011 |
Peter Qiu, Gaithersburg, MD US
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20110318731 | QUANTITATIVE HELICASE ASSAY - Disclosed herein are methods and kits relating to detection and quantitation of helicase activity. | 12-29-2011 |
20120004128 | FAST RESULTS HYBRID CAPTURE ASSAY AND ASSOCIATED STRATEGICALLY TRUNCATED PROBES - Strategically truncated probes specific for high-risk HPV nucleic acids, and methods for making and using the same, are disclosed herein. The disclosed probes, and methods of use thereof, permit fast and reliable detection of human papillomavirus in clinical samples without significant cross-reaction. | 01-05-2012 |
Qi Qiu, Cary, NC US
Patent application number | Description | Published |
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20100239064 | Methods, systems, and computer program products for multiplexing computed tomography - Methods, systems, and computer program products for multiplexing computed tomography are disclosed. According to one aspect, the subject matter described herein can include illuminating an object with a plurality of x-ray beams from a plurality of viewing angles, wherein each x-ray beam has a distinct waveform; detecting the x-ray intensities of the plurality of pulsed x-ray beams as a function of time, and extracting individual projection image data from the detected x-ray intensities based on the distinct waveforms of the x-ray beams for combining the projection image data to generate three-dimensional tomographic image data of the object. | 09-23-2010 |
20120286692 | ELECTRON SOURCE - An electron source includes a plurality of electron emission cathodes and at least one control electrode. A gate current regulator is provided for regulation of current flowing through the at least one control electrode. | 11-15-2012 |
Quofang Qiu, Springfield, MO US
Su Qiu, Ann Arbor, MI US
Patent application number | Description | Published |
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20090123480 | BIVALENT SMAC MIMETICS AND THE USES THEREOF - The invention relates to bivalent mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis. | 05-14-2009 |
20100273799 | SMALL MOLECULE INHIBITORS OF MDM2 AND THE USES THEREOF - The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s). | 10-28-2010 |
20100273812 | DIAZO BICYCLIC SMAC MIMETICS AND THE USES THEREOF - The invention relates to diazo bicyclic mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis. | 10-28-2010 |
20120101092 | SMALL MOLECULE INHIBITORS OF MDM2 AND THE USES THEREOF - The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s). | 04-26-2012 |
20120309961 | DIAZO BICYCLIC SMAC MIMETICS AND THE USES THEREOF - The invention relates to diazo bicyclic mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis. | 12-06-2012 |
Tongqing Qiu, Atlanta, GA US
Patent application number | Description | Published |
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20100132037 | SYSTEM AND METHOD TO LOCATE A PREFIX HIJACKER WITHIN A ONE-HOP NEIGHBORHOOD - Method, system and computer-readable medium to locate a prefix hijacker of a destination prefix within a one-hop neighborhood on a network. The method includes generating one-hop neighborhoods from autonomous system (AS)-level paths of plural monitors to a destination prefix. The method also includes determining a suspect set of AS identifiers resulting from a union of the one-hop neighborhoods. The method further includes calculating a count and a distance associated with each AS identifier of the suspect set. The count indicates how often the AS identifier appeared in the one-hop neighborhoods. The distance indicates a total distance from the AS identifier to AS identifiers associated with the plural monitors. Yet further, the method includes generating a one-hop suspect set of AS identifiers from the suspect set that have highest counts and highest distances. | 05-27-2010 |
Tongqing Qiu, Randolph, GA US
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20130097703 | SYSTEM AND METHOD TO LOCATE A PREFIX HIJACKER WITHIN A ONE-HOP NEIGHBORHOOD - Method, system and computer-readable device to locate a prefix hijacker of a destination prefix within a one-hop neighborhood. The method includes generating one-hop neighborhoods from autonomous system-level paths associated with a plurality of monitors to a destination prefix. The method also includes determining a suspect set of autonomous system identifiers resulting from a union of the one-hop neighborhoods. The method further includes calculating a count and a distance associated with each autonomous system identifier in the suspect set of autonomous system identifiers. The count represents how often an autonomous system identifier appears in the one-hop neighborhoods. The distance represents a total number of autonomous system identifiers from the autonomous system identifier to autonomous system identifiers associated with the plurality of monitors. Yet further, the method includes generating a one-hop suspect set including autonomous system identifiers in the suspect set that have a greatest sum of the count and the distance. | 04-18-2013 |
Tongqing Qiu, Smyrna, GA US
Patent application number | Description | Published |
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20110307913 | Modeling User Activity Information Associated with a Network System - Systems and methods to model user activity information associated with a network system are provided. A particular method includes receiving, at a computing device, a request for user activity information associated with selected channels of a television access network that provides multimedia content to users. The method includes executing a model of user activity associated with the television access network at the computing device. The model estimates the user activity information as user multimedia access demands during particular time periods within a day. The method also includes storing the user activity information at a computer-readable non-transitory storage medium. | 12-15-2011 |
Tongquing Qiu, Smyrna, GA US
Patent application number | Description | Published |
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20130254887 | Prefix Hijacking Detection Device and Methods Thereof - A method of placing prefix hijacking detection modules in a communications network includes selecting a set of candidate locations. For each candidate location, a detection coverage ratio with respect to a target Autonomous System is calculated. Based on the relative size of the coverage ratios, proposed locations for the prefix hijacking detection modules are determined. | 09-26-2013 |
Tonqing Qiu, Smyrna, GA US
Patent application number | Description | Published |
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20110153801 | Prefix Hijacking Detection Device and Methods Thereof - A method of placing prefix hijacking detection modules in a communications network includes selecting a set of candidate locations. For each candidate location, a detection coverage ratio with respect to a target Autonomous System is calculated. Based on the relative size of the coverage ratios, proposed locations for the prefix hijacking detection modules are determined. | 06-23-2011 |
Weibin Qiu, Urbana, IL US
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20100159705 | METHOD OF PLASMA ETCHING GA-BASED COMPOUND SEMICONDUCTORS - A method of plasma etching Ga-based compound semiconductors includes providing a process chamber and a source electrode adjacent thereto. The chamber contains a Ga-based compound semiconductor sample in contact with a platen which is electrically connected to a first power supply, and the source electrode is electrically connected to a second power supply. SiCl | 06-24-2010 |
20100159706 | METHOD OF PLASMA ETCHING GA-BASED COMPOUND SEMICONDUCTORS - A method of plasma etching Ga-based compound semiconductors includes providing a process chamber and a source electrode adjacent to the process chamber. The process chamber contains a sample comprising a Ga-based compound semiconductor. The sample is in contact with a platen which is electrically connected to a first power supply, and the source electrode is electrically connected to a second power supply. The method includes flowing SiCl | 06-24-2010 |
Wenbin Qiu, Wichita, KS US
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20120226375 | DUAL LOOP CONTROL OF CERAMIC PRECURSOR EXTRUSION BATCH - A control strategy for producing high quality extrudates, including the steps of monitoring the temperature of a ceramic precursor batch by measuring the temperature of the batch material either directly or indirectly by measuring the temperature of a component of the extruder proximate to the die and transmitting the temperature data to an extrusion control system which comprises a master controller ( | 09-06-2012 |
20130192205 | SYSTEMS AND METHODS FOR CONTROLLING TEMPERATURE AND TOTAL HYDROCARBON SLIP - Systems and methods for controlling temperature and total hydrocarbon slip in an exhaust system are provided. Control systems can comprise an oxidation catalyst, a particulate filter, a fuel injector, and a processor for controlling a fuel injection based on an oxidation catalyst model. Example system includes a virtual sensor comprising a controller for calculating and providing the total hydrocarbon slip to subsystems for after-treatment management based on modeling the oxidation catalyst. Example methods for controlling the temperature and the total hydrocarbon slip in an exhaust system include the steps of providing an oxidation catalyst model, monitoring a condition of the exhaust system, calculating a hydrocarbon fuel injection flow rate and controlling a fuel injection. The example methods further include the steps of determining an error in the oxidation catalyst model based on the monitored condition and changing the oxidation catalyst model to reduce the error. | 08-01-2013 |
Wulin Qiu, Snellville, GA US
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20110210073 | POLYMERIC SORBENTS FOR REMOVING LOW LEVEL CONTAMINANTS - The present invention relates to functionalized polymeric sorbents and processes of employing them to remove low level contaminants from fluid streams. Poly(glycidyl methacrylate-co-trimethylolpropane trimethacrylate) functionalized with a compound having the structure NH | 09-01-2011 |
Xiahua Qiu, Midland, MI US
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20100069574 | ETHYLENE/ALPHA-OLEFINS BLOCK INTERPOLYMERS - Embodiments of the invention provide a class of ethylene/α-olefin block interpolymers. The ethylene/α-olefin interpolymers are characterized by an average block index, ABI, which is greater than zero and up to about 1.0 and a molecular weight distribution, M | 03-18-2010 |
Xianbao Qiu, Philadelphia, PA US
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20100304986 | MECHANICALLY ACTUATED DIAGNOSTIC DEVICE - Disclosed are mechanically-actuated devices for transporting fluids within a microfluidic circuit and performing diagnostic operations on a sample. Also disclosed are related methods for performing sample analysis effected by the motion of an actuator proximate to a microfluidic system. | 12-02-2010 |
Xianbo Qiu, Philadelphia, PA US
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20100035349 | Biodetection Cassette with Automated Actuator - Provided are analysis cassettes that include removable sealing layers and deformable connector layers that place various channels, chambers, and reservoirs on the cassettes into fluid communication with one another. The cassettes are suitable for use in self-contained, immunoassay devices that may be operated in an automated fashion. Also disclosed are methods for analyzing samples by use of the disclosed cassettes. | 02-11-2010 |
20120315638 | Moisture-Activated Self-Heating Analysis Device - Provided are disposable, moisture-activated, self-heating cartridges useful for, e.g., isothermal nucleic acid amplification, incubation, and thermal actuation, and visual fluorescent detection of the amplification products. These devices may be self-contained and do not require any special instruments to operate. | 12-13-2012 |
Xianyang Qiu, Mystic, CT US
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20080206189 | METHOD OF TREATING CANCER BY ADMINISTERING CONJUGATES COMPRISING HUMAN IL-18 AND SUBSTITUTION MUTANTS THEREOF - Human interleukin-18 (IL-18) polypeptides and substitution mutants thereof were conjugated to water-soluble polymers at specific sites on the human IL-18 protein. These conjugated human IL-18 and substitution mutants thereof retain biological activity. These conjugated cytokines demonstrate enhanced and unexpected biological properties when compared to the corresponding unconjugated cytokines. | 08-28-2008 |
Xiaohong Qiu, Rosemount, MN US
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20100114059 | SYSTEM AND METHOD FOR DELIVERY OF BIOLOGIC AGENTS - A delivery system for delivering a therapeutic agent to a patient includes a catheter, a stop feature, a container and a bar. The catheter has a proximal end and a distal end and includes a body defining a lumen that extends to the distal end of the catheter. The stop feature is in proximity to the distal end of the catheter. The container is configured to house the therapeutic agent and is insertable and slidably disposable in the lumen of the catheter. The container is also configured to engage the stop feature of the catheter. The bar is slidably disposable in the lumen of the catheter. Sliding of the bar distally in the lumen forces the therapeutic agent out of the container and out of the lumen when the container is engaged with the stop feature. The stop feature is configured to inhibit the container from exiting the lumen. | 05-06-2010 |
Xiaohong Qiu, Edina, MN US
Patent application number | Description | Published |
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20110300107 | Compositions and Methods to Treat Cardiac Pacing Conditions - The method may include administering to a subject in need thereof an effective amount of an HCN polynucleotide. The HCN polynucleotide includes a nucleotide sequence encoding an HCN polypeptide having channel activity. The amino acid sequence of the HCN polypeptide and the amino acid sequence of a reference polypeptide have at least 80% identity, where the reference polypeptide begins with an amino acid selected from amino acids 92-214 and ends with an amino acid selected from amino acids 723-1188 of SEQ ID NO:8. An example of a reference polypeptide is amino acids 214-723 of SEQ ID NO:8. The HCN polynucleotide may be DNA or RNA. | 12-08-2011 |
20110301568 | Systems and Methods to Treat Cardiac Pacing Conditions - The method may include administering to a subject in need thereof an effective amount of an HCN polynucleotide. The HCN polynucleotide includes a nucleotide sequence encoding an HCN polypeptide having channel activity. The amino acid sequence of the HCN polypeptide and the amino acid sequence of a reference polypeptide have at least 80% identity, where the reference polypeptide begins with an amino acid selected from amino acids 92-214 and ends with an amino acid selected from amino acids 723-1188 of SEQ ID NO:8. An example of a reference polypeptide is amino acids 214-723 of SEQ ID NO:8. The HCN polynucleotide may be DNA or RNA. | 12-08-2011 |
20110319478 | Compositions to Treat Cardiac Pacing Conditions - The HCN polynucleotide includes a nucleotide sequence encoding an HCN polypeptide having channel activity. The amino acid sequence of the HCN polypeptide and the amino acid sequence of a reference polypeptide have at least 80% identity, where the reference polypeptide begins with an amino acid selected from amino acids 92-214 and ends with an amino acid selected from amino acids 723-1188 of SEQ ID NO:8. An example of a reference polypeptide is amino acids 214-723 of SEQ ID NO:8. The HCN polynucleotide may be DNA or RNA. The HCN polynucleotide may be present in a vector, such as a viral vector (including, for instance, a single strand adeno-associated virus or a self complementary adeno-associated virus), a transposon vector, or a plasmid vector. | 12-29-2011 |
Xiaohua S. Qiu, Midland, MI US
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20140170314 | COMPOSITE POLYAMIDE MEMBRANE DERIVED FROM MONOMER INCLUDING AMINE-REACTIVE AND PHOSPHOROUS-CONTAINING FUNCTIONAL GROUPS - A method for making a composite polyamide membrane comprising the steps of applying a polyfunctional amine monomer and polyfunctional acyl halide monomer to a surface of the porous support and interfacially polymerizing the monomers to form a thin film polyamide layer, wherein the method is includes at least one of the following steps: i) conducting the interfacial polymerization in the presence of a monomer comprising at least one phosphorous-containing functional group or salt thereof and an at least one amine-reactive functional group; and/or ii) applying such a monomer to the thin film polyamide layer. | 06-19-2014 |
20140206900 | METHOD FOR PREPARING HIGH PURITY MONO-HYDROLYZED ACYL HALIDE COMPOUND - A method for preparing a high purity (e.g. greater than 70 wt. %) mono-hydrolyzed acyl halide compound as a precipitate from solution comprising the steps of preparing a solution comprising: i) at least 80 v/v % of a hydrocarbon solvent, ii) water at a molar concentration greater than its solubility limit within the solvent but less that its solubility limit in solution, iii) a tri-hydrocarbyl phosphate compound, and iv) a polyfunctional acyl halide compound at molar ratio to both water and the tri-hydrocarbyl phosphate compound of at least 1:1. | 07-24-2014 |
Xiaohua Sam Qiu, Midland, MI US
Patent application number | Description | Published |
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20120129417 | ETHYLENIC POLYMER AND ITS USE - Ethylenic polymers comprising low levels of total unsaturation are disclosed. Compositions using such ethylene polymers and fabricated articles made from them are also disclosed. | 05-24-2012 |
20130287944 | COMPOSITE POLYAMIDE MEMBRANE - A method for making a composite polyamide membrane including the steps of applying a polyfunctional amine monomer and polyfunctional acyl halide monomer to a surface of the porous support and interfacially polymerizing the monomers to form a thin film polyamide layer, wherein the method is includes at least one of the following steps: i) conducting the interfacial polymerization in the presence of a subject monomer comprising an aromatic moiety substituted with a single carboxylic acid functional group or salt thereof and a single amine-reactive functional group; and/or ii) applying such a monomer to the thin film polyamide layer. Many additional embodiments are described including applications for such membranes. | 10-31-2013 |
20130287945 | COMPOSITE POLYAMIDE MEMBRANE - A method for making a composite polyamide membrane comprising the steps of applying a polyfunctional amine monomer and polyfunctional acyl halide monomer to a surface of the porous support and interfacially polymerizing the monomers to form a thin film polyamide layer, wherein the method is includes at least one of the following steps: i) conducting the interfacial polymerization in the presence of a C | 10-31-2013 |
20130287946 | COMPOSITE POLYAMIDE MEMBRANE - A method for making a composite polyamide membrane including the steps of applying a polyfunctional amine monomer and polyfunctional acid halide monomer to a surface of the porous support and interfacially polymerizing the monomers to form a thin film polyamide layer, wherein the method is includes at least one of the following steps: i) conducting the interfacial polymerization in the presence of an additional monomer comprising an aromatic moiety at least one carboxylic acid functional group or salt thereof and a single amine-reactive functional group; and/or ii) applying such a monomer to the thin film polyamide layer. Many additional embodiments are described including applications for such membranes. | 10-31-2013 |
20140264161 | IN-SITU METHOD FOR PREPARING HYDROLYZED ACYL HALIDE COMPOUND - An in-situ method for preparing a hydrolyzed, acyl halide-containing compound by combining a reactant including a plurality of acyl halide functional groups containing reactant, a tri-hydrocarbyl phosphate compound and water within a hydrocarbon or halogenated hydrocarbon solvent. | 09-18-2014 |
20140264162 | METHOD FOR SOLUBILIZING CARBOXYLIC ACID-CONTAINING COMPOUND IN HYDROCARBON SOLVENT - A method for increasing the solubility of a hydrocarbon compound comprising an aliphatic or arene moiety substituted with at least one acyl halide and at least one carboxylic acid functional group within a hydrocarbon solvent, wherein the method includes the step of preparing a solution comprising: at least 80 v/v % of the hydrocarbon solvent, the hydrocarbon compound, and a tri-hydrocarbyl phosphate compound, wherein the concentration of the hydrocarbon compound is greater than its solubility limit within the solvent but less than its solubility limit in the solution and the hydrocarbon. | 09-18-2014 |
20140272134 | COMPOSITE POLYAMIDE MEMBRANE DERIVED FROM CARBOXYLIC ACID CONTAINING ACYL HALIDE MONOMER - A method for making a composite polyamide membrane comprising the step of applying polyfunctional amine and acid halide monomers to a surface of a porous support and interfacially polymerizing the monomers to form a thin film polyamide layer. The method further includes the step of conducting the interfacial polymerization in the presence of: a carboxylic acid monomer comprising an aliphatic or aromatic moiety substituted with single carboxylic acid functional group and at least one acyl halide functional group, and a tri-hydrocarbyl compound. | 09-18-2014 |
Xiaoxing Qiu, Gumee, IL US
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20120288516 | Markers of XMRV Infection And Uses Thereof - The present invention relates generally to assays for the detection of Xenotropic Murine Leukemia Virus-related Retrovirus (“XMRV”) and diseases associated with XMRV infection. Additionally, the invention relates to specific XMRV antigens capable of inducing an immunogenic response as well as XMRV-related nucleic acids having significant diagnostic, screening, and therapeutic utilities. | 11-15-2012 |
Xiaoxing Qiu, Gurnee, IL US
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20110135674 | Markers of XMRV Infection and Uses Thereof - The present invention relates generally to assays for the detection of Xenotropic Murine Leukemia Virus-related Retrovirus (“XMRV”) and diseases associated with XMRV infection. Additionally, the invention relates to specific XMRV antigens capable of inducing an immunogenic response as well as XMRV-related nucleic acids having significant diagnostic, screening, and therapeutic utilities. | 06-09-2011 |
20110137015 | Markers of XMRV Infection and Uses Thereof - The present invention relates generally to assays for the detection of Xenotropic Murine Leukemia Virus-related Retrovirus (“XMRV”) and diseases associated with XMRV infection. Additionally, the invention relates to specific XMRV antigens capable of inducing an immunogenic response as well as XMRV-related nucleic acids having significant diagnostic, screening, and therapeutic utilities. | 06-09-2011 |
20120100632 | MONOCLONAL ANTIBODIES TO HUMAN IMMUNODEFICIENCY VIRUS AND USES THEREOF - The present invention relates to novel monoclonal antibodies which may be used in the detection of Human Immunodeficiency Virus (HIV). These antibodies exhibit an unusually high degree of sensitivity, a remarkably broad range of specificity, and bind to novel shared, non-cross-reactive epitopes. In particular, the monoclonal antibodies of the present invention may be utilized to detect HIV-1 antigen and HIV-2 core antigen in a patient sample. | 04-26-2012 |
20120171235 | MARKERS OF XMRV INFECTION AND USES THEREOF - The present invention relates generally to assays for the detection of Xenotropic Murine Leukemia Virus-related Retrovirus (“XMRV”) and diseases associated with XMRV infection. Additionally, the invention relates to specific XMRV antigens capable of inducing an immunogenic response as well as XMRV-related nucleic acids having significant diagnostic, screening, and therapeutic utilities. | 07-05-2012 |
20130130233 | MONOCLONAL ANTIBODIES TO HUMAN IMMUNODEFICIENCY VIRUS AND USES THEREOF - The present invention relates to novel monoclonal antibodies which may be used in the detection of Human Immunodeficiency Virus (HIV). These antibodies exhibit an unusually high degree of sensitivity, a remarkably broad range of specificity, and bind to novel shared, non-cross-reactive epitopes. In particular, the monoclonal antibodies of the present invention may be utilized to detect HIV-1 antigen and HIV-2 core antigen in a patient sample. | 05-23-2013 |
Xiayang Qiu, Mystic, CT US
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20100068199 | PCSK9 ANTAGONISTS - The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acid. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease, including treatment of hypercholesterolemia. | 03-18-2010 |
20110052621 | PCSK9 VACCINE - The present invention relates to the provision of novel immunogens comprising an antigenic PCSK9 peptide linked to an immunogenic carrier for the prevention, treatment or alleviation of PCSK9-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine. | 03-03-2011 |
20130273069 | PCSK9 ANTAGONISTS - The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acid. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease, including treatment of hypercholesterolemia. | 10-17-2013 |
Xueping Qiu, Rutland, VT US
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20130251921 | MINERAL COMPOSITION, ESPECIALLY FOR USE IN PAPER FILLERS AND PAPER OR PLASTIC COATINGS - A mineral composition comprising mineral particles, said mineral particles, when in a densely compacted bed form, having a volume defined median pore diameter from 0.01 to 0.04 micrometre, and having an intruded total specific void volume of 0.1-0.3 cm | 09-26-2013 |
Xueting Qiu, West Bloomfield, MI US
Patent application number | Description | Published |
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20080207850 | Melamine Polyols and Coatings Thereof - Novel low viscosity oligomeric polyols and the use thereof in coating compositions are disclosed. The novel low viscosity oligomeric polyols may be prepared by reacting at least one melamine aldehyde resin and at least one of α,β-diol, α,γ-diol, or mixture thereof. The reaction may occur in the presence of an acid catalyst. Coating compositions with a low VOC able to cure under ambient and forced dry conditions while providing good application and performance characteristics, such as an improved scratch resistance, are also disclosed. | 08-28-2008 |
Yang Qiu, Cary, NC US
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20100273661 | Methods and Kits for Predicting Treatment Response in Type II Diabetes Mellitus Patients - A method for predicting treatment response of a type II diabetes patient to rosiglitazone is provided. The method involves at least one sample from a patient having type II diabetes and analyzing biomarkers predictive of a patient who will respond to treatment with rosiglitazone. The biomarkers include, at least, interleukin-8, histidine, citrate. These biomarkers are identified in at least one classification analyses selected from the group consisting of a majority-vote based classifier and support-vector machine (SVM) classifier. Also provided is a method for predicting treatment response of a type II diabetes patient to glyburide at 8 weeks post-initiation of therapy. The method involves obtaining a sample from a type II diabetes patient who has been treated with glyburide for about 4 weeks and analyzing biomarkers predictive of a patient who will respond to treatment with glyburide at 8 weeks. The biomarkers useful in this method include, at least, sphingomyelin 23:1 and L-phenylalanine. Also provided are kits useful for the methods of the invention. | 10-28-2010 |
Yang Qiu, Blacksburg, VA US
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20080298090 | Digital Constant On-Time Power Supply Control - A switched voltage regulator provides improved regulation at a lower clock rate/sampling frequency (e.g. several orders of magnitude lower than would be required for comparable regulation) while using a low resolution digital pulse width modulator such that limit cycle oscillations occur (and thus of low cost and complexity and small size) by limiting the amplitude of limit cycle oscillations which therefore need not be avoided by more complex arrangements which are not commercially feasible. Limiting of amplitude of limit cycle oscillations is achieved by adding essentially a digitized ripple voltage signal corresponding to the difference between the output of the voltage regulator and an average output of the voltage regulator as an input to the digital pulse width modulator. Performance of this arrangement may be enhanced by adding a ramp signal to the digitized ripple voltage signal and even further enhanced by limiting the ramp signal to a range which corresponds to steady state operation but not transients. | 12-04-2008 |
Yihong Qiu, Vernon Hills, IL US
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20100021393 | Pharmaceutical Compositions Comprising Effervescent Agents and Fenofibrate - A pharmaceutical composition comprising at least one effervescent agent and a fibrate and a process for making such composition. The fibrate is fenofibrate and the effervescent agent are in a dosage form. The dosage form increases dissolution and absorption of fenofibrate in biological conditions where the form contacts acidic gastric fluid after oral administration. | 01-28-2010 |
Yongjian Qiu, Greenville, SC US
Patent application number | Description | Published |
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20080247121 | HIGH VOLTAGE SOLID ELECTROLYTIC CAPACITORS USING CONDUCTIVE POLYMER SLURRIES - A method for forming a capacitor including forming an anode from a valve metal; forming an oxide on the anode to form an anodized anode; dipping the anodized anode into a slurry of conductive polymer; drying the intrinsically conductive polymer; and providing external terminations in electrical contact with the anode and the conductive polymer. | 10-09-2008 |
20080250620 | Process for manufacturing low ESR conductive polymer based solid electrolytic capacitors - A method for maintaining quality of monomer during a coating process for intrinsically conductive polymer which suppresses unwanted by-products. A neutralization process using a base or anion exchange resin is used batch-wise or continuous. | 10-16-2008 |
20080283409 | Use of conjugated oligomer as additive for forming conductive polymers - A process for forming a capacitor. The process includes providing an anode; providing a dielectric on the anode; exposing the anode to a polymer precursor solution comprising monomer, conjugated oligomer and optionally solvent and polymerizing the polymer precursor. The ratio between monomer and conjugated oligomer ranges from 99.9/0.1 to 75/25 by weight. The solvent content in the polymer precursor solution is from 0 to 99% by weight. | 11-20-2008 |
20080299371 | Anodes with corner and edge modified designs - Porous sintered anode bodies for capacitors formed from valve metals are treated by electrolysis to form a dielectric layer and coated with cathode layers. When standard parallelpiped shapes are used, cathode coverage at the edges and corners is non-uniform and failures occur at those locations. Rectangular prisms, obround prisms and cylindrical prisms are formed with transition surfaces at edges and corners, such as chamfers and curves, to enhance cathode layer uniformity. The transition surface greatly enhances the application of polymer slurries. | 12-04-2008 |
20100053849 | ANODES WITH CORNER AND EDGE MODIFIED DESIGNS - Porous sintered anode bodies for capacitors formed from valve metals are treated by electrolysis to form a dielectric layer and coated with cathode layers. When standard parallelepiped shapes are used, cathode coverage at the edges and corners is non-uniform and failures occur at those locations. Rectangular prisms, obround prisms and cylindrical prisms are formed with transition surfaces at edges and corners, such as chamfers and curves, to enhance cathode layer uniformity. The transition surface greatly enhances the application of polymer slurries. | 03-04-2010 |
20100246096 | USE OF CONJUGATED OLIGOMER AS ADDITIVE FOR FORMING CONDUCTIVE POLYMERS - A process for forming a capacitor. The process includes providing an anode; providing a dielectric on the anode; exposing the anode to a polymer precursor solution comprising monomer, conjugated oligomer and optionally solvent and polymerizing the polymer precursor. The ratio between monomer and conjugated oligomer ranges from 99.9/0.1 to 75/25 by weight. The solvent content in the polymer precursor solution is from 0 to 99% by weight. | 09-30-2010 |
20110149477 | SOLID ELECTROLYTIC CAPACITOR AND METHOD OF MANUFACTURE - An improved solid electrolytic capacitor and method of forming a solid electrolytic capacitor is described. The method includes forming an anode comprising a valve metal or conductive oxide of a valve metal wherein an anode lead extension protrudes from the anode. A dielectric is formed on the anode and a cathode layer is formed on the dielectric. The anode, dielectric, and cathode layer are encased in a non-conducting material and the anode lead extension is exposed outside of the encasement at a side surface. A conductive metal layer is adhered to the anode lead extension which allows termination preferably by electrically connecting a preformed solid metal terminal, most preferably an L shaped terminal, to the conductive metal layer at the side surface. | 06-23-2011 |
20110252613 | HIGH VOLTAGE AND HIGH EFFICIENCY POLYMER ELECTROLYTIC CAPACITORS - A capacitor, and method of making a capacitor, is provided wherein the capacitor has exceptionally high break down voltage. The capacitor has a tantalum anode with an anode wire attached there to. A dielectric film is on the tantalum anode. A conductive polymer is on the dielectric film. An anode lead is in electrical contact with the anode wire. A cathode lead is in electrical contact with the conductive polymer and the capacitor has a break down voltage of at least 60 V. | 10-20-2011 |
20120063063 | PROCESS FOR SOLID ELECTROLYTIC CAPACITORS USING POLYMER SLURRIES - A process for forming a solid electrolytic capacitor and an electrolytic capacitor formed by the process. The process includes: providing an anode wherein the anode comprises a porous body and an anode wire extending from the porous body; apply a thin polymer layer onto the dielectric, and | 03-15-2012 |
20120069493 | SOLID ELECTROLYTIC CAPACITOR AND METHOD OF MANUFACTURING A SOLID ELECTROLYTIC CAPACITOR - Provided is a method for forming a capacitor. The method includes: providing an anode with a dielectric thereon and a conductive node in electrical contact with the anode; | 03-22-2012 |
20120206859 | MATERIALS AND METHODS FOR IMPROVING CORNER AND EDGE COVERAGE OF SOLID ELECTROLYTIC CAPACITORS - A process for preparing a solid electrolytic capacitor comprising application of coverage enhancing catalyst followed by application of a conducting polymer layer. Coverage enhancing catalyst is removed after coating and curing. | 08-16-2012 |
20120206860 | PROCESS FOR PRODUCING ELECTROLYTIC CAPACITORS AND CAPACITORS MADE THEREBY - A process for preparing a solid electrolytic capacitor comprising application of a non-ionic polyol prior to application of a conducting polymer layer. | 08-16-2012 |
Yongjian Qiu, Simpsonville, SC US
Patent application number | Description | Published |
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20130250486 | Solid Electrolytic Capacitor and Method of Manufacture - An improved solid electrolytic capacitor and method of forming a solid electrolytic capacitor is described. The method includes forming an anode comprising a valve metal or conductive oxide of a valve metal wherein an anode lead extension protrudes from the anode. A dielectric is formed on the anode and a cathode layer is formed on the dielectric. The anode, dielectric, and cathode layer are encased in a non-conducting material and the anode lead extension is exposed outside of the encasement at a side surface. A conductive metal layer is adhered to the anode lead extension which allows termination preferably by electrically connecting a preformed solid metal terminal, most preferably an L shaped terminal, to the conductive metal layer at the side surface. | 09-26-2013 |
20140160633 | Solid Electrolytic Capacitor and Method of Manufacturing a Solid Electrolytic Capacitor - Provided is a method for forming a capacitor. The method includes: | 06-12-2014 |
20140168859 | Solid Electrolytic Capacitor and Method of Manufacturing a Solid Electrolytic Capacitor - Provided is a method for forming a capacitor. The method includes: | 06-19-2014 |
20140301022 | Process for Producing Electrolytic Capacitors and Capacitors Made Thereby - A process for preparing a solid electrolytic capacitor comprising application of a non-ionic polyol prior to application of a conducting polymer layer. | 10-09-2014 |
Yongxing Qiu, Duluth, GA US
Patent application number | Description | Published |
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20080203592 | Method for imparting hydrogel contact lenses with desired properties - A cost-effective method for making hydrogel contact lenses with desired properties, such as antimicrobial property and/or increased surface hydrophilicity. The method comprises a step of contacting a dry or unhydrated hydrogel contact lens with an aqueous solution (or hydrating solution) containing silver nanoparticles and/or a lubricant or wetting agent. By using a method of the invention, resultant hydrogel contact lenses can have antimicrobial capability and/or enhanced lens wearer's comfort. | 08-28-2008 |
20080260804 | Medical devices having antimicrobial coatings thereon - The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial coating including at least one layer of polyquat of formula (I) or (II). The antimicrobial coating on the medical device of the invention has a high antimicrobial efficacy against microorganisms including Gram-positive and Gram-negative bacterial, a low toxicity, low coefficient of friction, and increased hydrophilicity while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial coating thereon. | 10-23-2008 |
20100016514 | Silicone Hydrogel Contact Lenses with Convertible Comfort Agents - The invention provides a silicone hydrogel contact lens including a hydrolyzable polymer. The hydrolyzable polymer can be converted by hydrolysis into a hydrophilic polymer which is capable of imparting the silicone hydrogel contact lens a hydrophilic surface without post-curing surface treatment. | 01-21-2010 |
20100120938 | POLYSILOXANE COPOLYMERS WITH TERMINAL HYDROPHILIC POLYMER CHAINS - The invention provides an actinically-crosslinkable linear polysiloxane copolymer. The actinically-crosslinkable polysiloxane copolymer can be used to prepare a silicone hydrogel contact lens having a hydrophilic surface without post-curing surface treatment. The invention is also related to a silicone hydrogel contact lens obtained from a lens-forming material including an actinically-crosslinkable polysiloxane copolymer of the invention and to a method for making an actinically-crosslinkable polysiloxane copolymer of the invention. In addition, the invention provides a non-crosslinkable linear polysiloxane copolymer capable of being used as a internal wetting agent which can render the surface of a silicone hydrogel contact lens hydrophilic. | 05-13-2010 |
20110133350 | METHODS FOR INCREASING THE ION PERMEABILITY OF CONTACT LENSES - Described herein are methods for increasing the ion permeability of a silicone hydrogel contact lens by adding a small amount of an ion-permeability-enhancing (“IP-enhancing”) hydrophilic vinylic monomer or macromer into a lens-forming material for cast-molding silicone hydrogel contact lenses, while not altering significantly the water content and/or the oxygen permeability of resultant lenses from the lens-forming material. | 06-09-2011 |
20120026457 | SILICONE HYDROGEL LENS WITH A CROSSLINKED HYDROPHILIC COATING - The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave. | 02-02-2012 |
20120026458 | SILICONE HYDROGEL LENSES WITH WATER-RICH SURFACES - The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort. | 02-02-2012 |
20120038888 | METHODS FOR IMAGING OCULAR DEVICES USING OPTICAL COHERENCE TOMOGRAPHY - Described herein are methods for imaging ocular devices. The methods generally involve (a) applying a scattering agent to the ocular device; and (b) imaging the ocular device using optical coherence tomography (OCT). The methods described herein provide useful structural information about the surface of the device with high sensitivity. | 02-16-2012 |
20120137635 | ATMOSPHERIC PLASMA COATING FOR OPHTHALMIC DEVICES - The invention provides a method of coating and thereby affecting the surface properties of a substrate such as a contact lens or other ophthalmic device. The method comprises the steps of generating an atmospheric plasma flow from a working gas and controlling the continuity of the atmospheric plasma flow with a power generator, and, introducing the atmospheric plasma flow to a substrate surface. | 06-07-2012 |
20120139137 | LENS MOLDS HAVING ATMOSPHERIC PLASMA COATINGS THEREON - The invention provides a method of making ophthalmic lenses with an enhanced quality and enhanced yield achieved by reducing mold separation force and lens-mold adhesion. The method comprises the steps of generating an atmospheric plasma flow from a working gas and controlling the continuity of the atmospheric plasma flow with a power generator, and, introducing the atmospheric plasma flow to a molding surface of a mold for making an ophthalmic lens (preferably contact lens, more preferably a silicone hydrogel contact lens) and increasing the surface hydrophobicity of the molding surface of the mold and thereby to reduce a mold separation force after molding a lens formulation in the mold. | 06-07-2012 |
20120276278 | MEDICAL DEVICES HAVING ANTIMICROBIAL COATINGS THEREON - The present invention provides a medical device, preferably a contact lens, which a core material and an antimicrobial metal-containing LbL coating that is not covalently attached to the medical device and can impart to the medical device an increased hydrophilicity. The antimicrobial metal-containing coating on a contact lens of the invention has a high antimicrobial efficacy against microorganisms including Gram-positive and Gram-negative bacterial and a low toxicity, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating thereon. | 11-01-2012 |
20130095235 | METHOD FOR MAKING UV-ABSORBING OPHTHALMIC LENSES - Described herein is a cost-effective and time-efficient method for making UV-absorbing contact lenses. In contrast to the conventional method for making UV-absorbing contact lenses which involves copolymerizing a lens forming composition including a UV-absorbing vinylic monomer, a method of the invention involves dipping a contact lens in a solution of UV-absorbing polymer comprising carboxyl-containing monomeric units and UV-absorbing monomeric units to form a UV-absorbing coating on the contact lens. | 04-18-2013 |
20130127077 | SILICONE HYDROGEL LENSES WITH CONVERTIBLE COMFORT AGENTS - The invention provides a silicone hydrogel contact lens including a hydrolyzable polymer. The hydrolyzable polymer can be converted by hydrolysis into a hydrophilic polymer which is capable of imparting the silicone hydrogel contact lens a hydrophilic surface without post-curing surface treatment. | 05-23-2013 |
20130224309 | ANTIMICROBIAL MEDICAL DEVICES - The present invention provides methods for making an antimicrobial medical device, preferably an antimicrobial ophthalmic device, more preferably an antimicrobial extended-wear contact lens, which contains silver nano-particles distributed uniformly therein. The antimicrobial medical device can exhibit antimicrobial activity over an extended period of time. | 08-29-2013 |
20130228943 | ANTIMICROBIAL MEDICAL DEVICES - The present invention provides methods for making an antimicrobial medical device, preferably an antimicrobial ophthalmic device, more preferably an antimicrobial extended-wear contact lens, which contains silver nano-particles distributed uniformly therein. The antimicrobial medical device can exhibit antimicrobial activity over an extended period of time. | 09-05-2013 |
20130250234 | SILICONE HYDROGEL LENSES WITH WATER-RICH SURFACES - The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort. | 09-26-2013 |
20130308093 | SILICONE HYDROGEL LENS WITH A CROSSLINKED HYDROPHILIC COATING - The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave. | 11-21-2013 |
20130337160 | AZETIDINIUM-CONTAINING COPOLYMERS AND USES THEREOF - The invention is related to azetidinium-containing copolymers and vinylic monomers and their uses in formation of non-silicone hydrogel coatings on silicone hydrogel contact lenses. | 12-19-2013 |
20140174031 | METHOD FOR APPLYING A COATING ONTO A SILICONE HYDROGEL LENS - The present invention generally relates to a method for applying a coating of hydrophilic polymers onto silicone hydrogel contact lenses to improve hydrophilicity and lubricity. In particular, the present invention is directed to a method for forming a coating on a contact lens, preferably a silicone hydrogel contact lens, directly in the primary package and maintaining the coated contact lens within said primary package until insertion of the coated contact lens in the eye of the contact lens user. The resultant silicone hydrogel contact lens has a coating with good hydrophilicity, improved lubricity and good durability and also can be used directly from the lens package by a patient without washing and/or rising. | 06-26-2014 |
20140356965 | METHOD FOR DETERMINING THE SURFACE CONCENTRATION OF CARBOXYL GROUPS ON A LENS - The invention is related to a method for qualifying and quantifying carboxyl groups on the surfaces of a silicone hydrogel contact lens. The method of the invention comprises the steps of: (a) obtaining silicone hydrogel contact lenses each of which comprises a silicone hydrogel lens body (i.e., bulk material) and a coating thereon, wherein the silicone hydrogel lens body is obtained from a lens formulation free of any polymerizable component including one or more carboxyl groups, wherein the coating comprises a polymer having carboxyl groups; (b) immersing a given number of the silicone hydrogel contact lenses in a fixed volume of a C | 12-04-2014 |
Yongxing Qiu, Atlanta, GA US
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20080247988 | METHODS OF MAKING AND USING SURFACTANT POLYMERS - Comblike, surfactant polymers for changing the surface properties of biomaterials are provided. Such surfactant polymers comprise a polymeric backbone of repeating monomeric units having functional groups for coupling with side chains, a plurality of hydrophobic side chains linked to said backbone via the functional groups, and a plurality of hydrophilic side chains linked to said backbone via the functional groups. The hydrophobic side chains comprise an alkyl group comprising from 2 to 18 methylene groups. The alkyl groups are linked to the polymeric backbone through ester linkages, secondary amine linkages, or, preferably, amide linkages. The hydrophilic side chain is selected from the group consisting of: a neutral oligosaccharide, which, preferably, has weight average molecular weight of less than 7000; a charged oligosaccharide, preferably a negatively charged oligosaccharide having a weight average molecular weight of less than 10,000; an oligopeptide of from about 3 to about 30 amino acid residues, said oligopeptide having an amino acid sequence which interacts with protein receptors on the surface of cells; and combinations thereof. Methods of making the surfactant polymers and using the surfactant polymers to alter the surface properties of a biomaterial are also provided. | 10-09-2008 |
Yongxing Qiu Qiu, Duluth, GA US
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20130034593 | Method for Making Medical Devices Having Antimicrobial Coatings Thereon - The present invention provides a method for preparing a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating on a medical device, wherein the antimicrobial metal-containing LbL coating comprises at least one layer of a negatively charged polyionic material having —COOAg groups and/or silver nanoparticles formed by reducing Ag | 02-07-2013 |
20140112994 | Method for Making Medical Devices Having Antimicrobial Coatings Thereon - The present invention provides a method for preparing a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating on a medical device, wherein the antimicrobial metal-containing LbL coating comprises at least one layer of a negatively charged polyionic material having —COOAg groups and/or silver nanoparticles formed by reducing Ag | 04-24-2014 |
Yongzhi Qiu, Charleston, SC US
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20120100185 | REGENERATION OF TISSUE WITHOUT CELL TRANSPLANTATION - The present invention provides methods and compositions for tissue regeneration without cell transplantation. | 04-26-2012 |
Yongzhi Qiu, Atlanta, GA US
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20130149214 | MICROVASCULAR FLUIDIC DEVICES, SYSTEMS AND METHODS RELATED THERETO - Microfluidic devices and processes are provided that relate to microvascular-sized systems configured to identify specific pathophysiological characteristics related to the interactions between, for example, blood cells and endothelial cells combined with geometric and flow constraints of microvasculature. The device may include at least one layer, the layer including a plurality of microvascularized-sized fluidic channels, the plurality of microfluidic channels being disposed in a geometric pattern. The layer may be composed of a hydrogel and/or a silicon elastomer. The channels may include subchannels of different lengths. | 06-13-2013 |
Yun Qiu, Ellicott City, MD US
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20100048671 | INHIBITION OF THE 44 KILODALTON ISOFORM OF PIM-1 KINASE RESTORES APOPTOSIS INDUCED BY CHEMOTHERAPEUTIC DRUGS IN CANCER CELLS - The present invention relates to a newly discovered 44 kD isoform of Pim-1 kinase made in human cells, and to the gene and messenger RNA for the 44 kilodalton isoform. The invention further describes methods and compounds for treating, especially prostate and hematopoietic cancer, by inhibiting expression of the 44 kD isoform of Pim-1 kinase, or its ability to phosphorylate Etk kinase and breast cancer resistance protein (BCRP). | 02-25-2010 |
20100068802 | NOVEL HUMAN ANDROGEN RECEPTOR ALTERNATIVE SPLICE VARIANTS AS BIOMARKERS AND THERAPEUTIC TARGETS - The present invention relates to novel androgen receptor splice variants (AR3, AR4, AR4b, AR5 and AR8) and variants and fragments thereof which have a role in the progression of androgen independent prostate cancer. The invention further relates to compositions and methods which can be used to identify and treat prostate cancer based on these novel androgen receptor splice variants, as well as methods for screening agents which modulate the activity and/or expression of the androgen receptor splice variants. Vectors, host cells and recombinant methods for producing the same and transgenic animals are also provided. | 03-18-2010 |
20120156770 | HUMAN ANDROGEN RECEPTOR ALTERNATIVE SPLICE VARIANTS - The present invention relates to novel androgen receptor splice variants (AR3, AR4, AR4b, AR5 and AR8) and variants and fragments thereof which have a role in the progression of androgen independent prostate cancer. The invention further relates to compositions and methods which can be used to identify and treat prostate cancer based on these novel androgen receptor splice variants, as well as methods for screening agents which modulate the activity and/or expression of the androgen receptor splice variants. Vectors, host cells and recombinant methods for producing the same and transgenic animals are also provided. | 06-21-2012 |
Yunping Qiu, Kannapolis, NC US
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20120040383 | Methods and Kits Relating To Metabolite Biomarkers For Colorectal Cancer - Embodiments of the present invention provide methods of assessing metabolite biomarkers to diagnose, monitor, prognose and treat colorectal cancer, as well as kits and systems in use thereof. In some embodiments, the metabolite biomarker profile of an subject suspected of having colorectal cancer may be compared to the metabolite biomarker profile of a healthy subject to determine if there are differences between the profiles indicative of colorectal cancer. In some embodiments, the stage of a subject's colorectal cancer may be determined. In certain embodiments, the metabolite biomarker profile of an subject may be useful in determining method of treatment for colorectal cancer. In other embodiments, the metabolite biomarker profiles of an subject having colorectal cancer may be compared prior to and after treatment to determine if there are differences between the profiles indicative of decreased colorectal cancer morbidity. | 02-16-2012 |
20140024132 | METHODS AND SYSTEMS USING INTEGRATED METABOLOMICS AND PHARMACOKINETICS FOR MULTI-COMPONENT DRUG EVALUATION - Disclosed are methods and systems for identifying biochemical changes in a subject in response to administration of a multi-component therapeutic and one or more active ingredients in the multi-component therapeutic. The methods and systems of the invention may be used to elucidate the interaction of the biological system's genome with its environments, and in the pharmacokinetic, pharmacodynamic and toxicology analysis of multi-component therapeutics. The metabolomics methods and systems of the invention can also be used in studies of plant derived agents to demonstrate biochemical alterations in response to the dynamic multi-component intervention. | 01-23-2014 |
Zai-Ming Qiu, St. Paul, MN US
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20110136704 | Methods of Treating a Hydrocarbon-Bearing Formation, a Well Bore, and Particles - Methods of treating articles using a compound represented by formula: (I) wherein each of X and Y is independently a thiol, a halogen, a hydrogen, a hydroxyl, a hydroalkyl, a carboxylic acid, an aldehyde, a carboxylic ester, or a carboxamide; R′ is hydrogen, alkyl, or aryl; and x and y are each independently 0 to 10, wherein x+y is at least 1 and articles treated by such methods. In some embodiments, the article is a hydrocarbon-bearing formation. In some embodiments, the article is a particle, and the method further comprises treating the article with a fluorochemical comprising at least one fluoroaliphatic segment and at least one hydrophilic segment. In some embodiments, the method is used to treat a well bore. | 06-09-2011 |
Zhaoyao Joe Qiu, Baton Rouge, LA US
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20100113315 | Additive composition comprising an amidized or imidized polymer - The invention relates to a process for an additive composition comprising an amidized or imidized polymer. The invention further relates to a highly grafted, multi-functional lubricant additive useful to improve the viscosity index and dispersancy properties of a lubricating oil composition. The present invention also relates to a method of extending lubricant drain intervals and improving fuel economy and fuel economy durability. The additive composition is prepared by: (A) reacting an olefin copolymer of ethylene and at least one C3 to C23 &agr;-olefin comprising from about 15 to 80 mole percent of ethylene, from about 20 to 85 mole percent of said C3 to C23 &agr;-olefin and from about 0 to 15 wt percent of a polyene, said copolymer having a number average molecular weight ranging from 1,000 to 500,000, with an olefinic carboxylic acid acylating agent, said process comprising heating said polymer to a molten condition at a temperature in the range of 60° C. to 240° C., grafting, in a first extruder or a first mixing device, said olefinic carboxylic acylating agent onto said copolymer, optionally subsequently reducing the molecular weight of said copolymer at a temperature in the range of 250° C. to 350° C., thereby producing a grafted, reduced molecular weight acylated copolymer having a number average molecular weight ranging from 1,000 to 80,000 and having at least 0.2-20 molecules of said carboxylic acid acylating agent grafted per 1000 C atoms of said olefin copolymer, and (B) reacting, in a second extruder or a second mixing device, said acylated copolymer made in (A) with a polyamine. | 05-06-2010 |
Zhen Qiu, Ann Arbor, MI US
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20110125029 | Targeted Dual-Axes Confocal Imaging Apparatus with Vertical Scanning Capabilities - An optical device is described that may be used as a microscope system for real-time, three-dimensional optical imaging. The device includes a miniature, fiber optic, intra-vital probe microscope that uses a dual-axes confocal architecture to allow for vertical scanning perpendicular to a surface of the sample (e.g., a tissue surface). The optical device can use off-axis illumination and collection of light to achieve sub-cellular resolution with deep tissue penetration. The optical device may be used as part of an integrated molecular imaging strategy using fluorescence-labeled peptides to detect cell surface targets that are up-regulated by the epithelium and/or endothelium of colon and breast tumors in small animal models of cancer. | 05-26-2011 |
Zhihao Qiu, Gaithersburg, MD US
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20100190175 | METHODS OF RANDOM MUTAGENESIS AND METHODS OF MODIFYING NUCLEIC ACIDS USING TRANSLESION DNA POLYMERASES - The invention is related generally to methods of amplifying or synthesizing or producing nucleic acid molecules using Translesion DNA polymerases. In particular, the invention relates to methods of introducing a random mutation into a nucleic acid and encoded polypeptide using Translesion DNA polymerases. The invention also relates to methods of introducing a modified nucleotide into a nucleic acid using Translesion DNA polymerases. The invention also relates to mutagenized and modified nucleic acid molecules and proteins produced by these methods, and to fragments or derivatives thereof. The invention also relates to vectors and host cells comprising mutagenized nucleic acid molecules, fragments, or derivatives. The invention also relates to the use of mutagenized nucleic acid molecules to produce desired polypeptides and uses of modified nucleic acid molecules to analyze samples. The invention also relates to kits or compositions or compounds for use in the invention or for carrying out the invention. | 07-29-2010 |