Patent application number | Description | Published |
20080205982 | Gating Impact Attenuator - The present invention relates primarily to highway safety devices, secondarily to on-board vehicle mounted safety devices and more particularly to enhancing the performance of such devices when occupants of vehicles are subjected to severe deceleration forces. | 08-28-2008 |
20080295522 | THERMO-ENERGY-MANAGEMENT OF SOLID-STATE DEVICES - The present invention reduces to practice discoveries made by the present inventors during their investigations into present-art-perceived-difficulties in thermal-management applications of solid-state devices. | 12-04-2008 |
20110250417 | Dimensional Lumber Structural Substitute - Dimensional lumber subjected to structural load regimes, where moment is the dominate load condition, usually fail structurally by initial localized compressive failure located at or near the maximum compressive extreme fiber. Said localized compressive failure, exhibited by buckling failure of maximum compressive fiber, results in an overall increase of section-modulus. The increase in section modulus, due to onset of structural failure, allows the lumber element in question to provide post-structural-failure increase in load-carrying-capacity with the trade-off of an increase in load-vs-deflection ratio. Said increase in load-carrying-capacity due to the increase in section-modulus, or thickening of the lumber element continues as an applied load is increased until the lumber element's tensile extreme fiber's capacity is exceeded, at which event the lumber element structurally fails catastrophically. The present invention, unlike previously disclosed compositions, unexpectedly mimics the stiffness and failure-mode structural characteristics of traditional dimensional lumber. A comparison of test data shows the present invention possesses unexpected improved properties that the present art does not have. | 10-13-2011 |
Patent application number | Description | Published |
20090151845 | PNEUMATIC TIRE - A pneumatic radial tire has a chipper in place of a traditional apex, the chipper located between a carcass main portion and turnup portion. The chipper layer may be composed of a chopped carbon fiber and aramid composite reinforced elastomeric layer. The tire sidewalls have a radial height SH and a section width SW located within a range of 0.4 to 0.44 of the sidewall radial height SH measured from the bead core. The section width SW may further be located within a range of 0.1″ to 0.3″ inches from a radially outward end of the chipper layer in a radial direction. The tread may of a dual layer construction, having a radially inward first layer formed of a relatively low rolling resistance compound and a radially outward second layer formed of a compound containing silica. | 06-18-2009 |
20100018618 | TIRE WITH TREAD HAVING A TWO-PLY TREAD CAP LAYER - The invention relates to a tire with a tread of a cap/base construction comprised of a two-ply (dual layered) tread cap rubber layer comprised of a combination of an outer tread cap layer and an inner tread cap layer together with an underlying tread base rubber layer which underlies the two-ply tread cap layer. The tread cap layer is of a lug and groove configuration with at least a portion of the grooves extending through the outer tread cap layer into the inner tread cap layer without extending to the tread base rubber layer. The outer tread cap rubber layer is comprised of a carbon black-rich rubber composition to promote dry traction for the tread running surface. The inner tread cap layer is comprised of a softer silica-rich rubber composition to promote wet traction for tread running surface as the outer tread cap layer wears away to expose the softer inner tread cap layer. | 01-28-2010 |
20110114240 | PNEUMATIC TIRE - A pneumatic radial tire having a circumferentially extending equatorial plane of the tire, the tire comprising a carcass, a tread radially outward of the carcass, the carcass comprising at least one carcass reinforcing ply, opposing bead portions, and opposing sidewalls, the carcass reinforcing ply having a main portion extending between the opposing bead portions and a pair of turnup portions, each turnup portion extending from one end of the main portion, each bead portion having a bead core, and a reinforcement cavity outward of each bead core, the cavity located between the main portion and one turnup portion of the at least one reinforcing ply, the tire characterized by:
| 05-19-2011 |
Patent application number | Description | Published |
20120071361 | Substrate Preparation Process - The present invention provides novel processes for the large scale preparation of arrays of polymer sequences wherein each array includes a plurality of different, positionally distinct polymer sequences having known monomer sequences. The methods of the invention combine high throughput process steps with high resolution photolithographic techniques in the manufacture of polymer arrays. | 03-22-2012 |
20120173158 | TIME-WARPED BACKGROUND SIGNAL FOR SEQUENCING-BY-SYNTHESIS OPERATIONS - Methods for analyzing signal data generated by sequencing of a polynucleotide strand using a pH-based method of detecting nucleotide incorporation(s). In an embodiment, the method comprises formulating a function that models the output signal of a representative empty well of a reactor array. A time transformation is applied to the empty well function to obtain a time-warped empty well function. The time-warped empty well function is fitted to an output signal from the loaded well representative of a flow that results in a non-incorporation event in the loaded well. The fitted time-warped empty well function can then be used to analyze output signals from the loaded well for other flows. | 07-05-2012 |
20120264621 | PHASE-PROTECTING REAGENT FLOW ORDERINGS FOR USE IN SEQUENCING-BY-SYNTHESIS - A method for nucleic acid sequencing includes disposing template polynucleotide strands in defined spaces on a sensor array, at least some of the template polynucleotide strands having a sequencing primer and a polymerase operably bound therewith; exposing the template polynucleotide strands to a series of flows of nucleotide species flowed according to a predetermined ordering; and determining, for each of the series of flows of nucleotide species, how many nucleotide incorporations occurred for that particular flow to determine a predicted sequence of nucleotides corresponding to the template polynucleotide strands, wherein the predetermined ordering (a) is not a series of consecutive repetitions of a 4-flow permutation of four different nucleotide species, (b) is not specifically tailored to a particular combination of a particular template polynucleotide strand to be sequenced and a particular sequencing primer to be used, and (c) comprises a phase-protecting flow ordering. | 10-18-2012 |
20130090860 | METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR MAKING BASE CALLS IN NUCLEIC ACID SEQUENCING - A method for nucleic acid sequencing includes: receiving a signal comprising measurements of a parameter measured in response to a plurality of nucleotide flows flowed in a space comprising a sample nucleic acid; normalizing the signal to obtain a normalized signal; adaptively normalizing the normalized signal to obtain an adaptively normalized signal; and predicting a sequence of base calls corresponding to the sample nucleic acid using the adaptively normalized signal. | 04-11-2013 |
20130231870 | METHODS AND COMPUTER PROGRAM PRODUCTS FOR COMPRESSION OF SEQUENCING DATA - A compression method includes measuring a waveform associated with a chemical event occurring on a sensor array, wherein the waveform comprises at least one region associated with expected measured values and at least one region associated with unpredictable measured values; applying a first compression process to the waveform, the first compression process including an averaging of one or more frames in one or more portions of the waveform; and applying a second compression process to the waveform, the second compression process including a truncating of data corresponding to a portion of the waveform that is not related to a nucleotide incorporation component of the waveform. | 09-05-2013 |
20130288904 | PHASE-PROTECTING REAGENT FLOW ORDERINGS FOR USE IN SEQUENCING-BY-SYNTHESIS - A method for nucleic acid sequencing includes: disposing a plurality of template polynucleotide strands, sequencing primers, and polymerases in a plurality of defined spaces of a sensor array; exposing template polynucleotide strands to a series of flows of nucleotide species, the series comprising a sequence of random flows; and obtaining, for each of the series of flows of nucleotide species, a signal indicative of how many nucleotide incorporations occurred for that particular flow to determine a predicted sequence of nucleotides corresponding to the template polynucleotide strands. | 10-31-2013 |
20140052381 | Systems and Methods for Detecting Homopolymer Insertions/Deletions - Systems and method for determining variants can receive mapped reads and determine a distribution of matched-filter residuals distribution from a plurality of reads at a homopolymer region. The distribution of matched-filter residuals can be fit to uni-modal and bi-modal models. Based on the model that best fits the distribution of matched-filter residuals, the heterozygosity of the sample and the absence or presence of an insertion/deletion in the homopolymer can be determined. | 02-20-2014 |
20140113281 | Methods, Systems, and Computer Readable Media for Repeat Sequencing - A method for sequencing a nucleic acid template includes: (a) performing a first sequencing process including flowing nucleotides and/or reagents to the nucleic acid template according to a first predetermined ordering of nucleotides and/or reagents to obtain a first sequencing result; (b) after the first sequencing process, performing a second sequencing process including flowing nucleotides and/or reagents to the nucleic acid template according to a second predetermined ordering of nucleotides and/or reagents to obtain a second sequencing result, the second predetermined ordering of nucleotides and/or reagents being different from the first predetermined ordering of nucleotides and/or reagents and at least one of the first and second predetermined orderings of nucleotides and/or reagents being designed for repeat sequencing; and (c) determining a sequence of bases corresponding to at least a portion of the nucleic acid template using both the first sequencing result and the second sequencing result. | 04-24-2014 |
20140296080 | Methods, Systems, and Computer Readable Media for Evaluating Variant Likelihood - A method for evaluating variant likelihood includes: providing a plurality of template polynucleotide strands, sequencing primers, and polymerase in a plurality of defined spaces disposed on a sensor array; exposing the plurality of template polynucleotide strands, sequencing primers, and polymerase to a series of flows of nucleotide species according to a predetermined order; obtaining measured values corresponding to an ensemble of sequencing reads for at least some of the template polynucleotide strands in at least one of the defined spaces; and evaluating a likelihood that a variant sequence is present given the measured values corresponding to the ensemble of sequencing reads, the evaluating comprising: determining a measurement confidence value for each read in the ensemble of sequencing reads and modifying at least some model-predicted values using a first bias for forward strands and a second bias for reverse strands. | 10-02-2014 |
20150087537 | Methods, Systems, Computer Readable Media, and Kits for Sample Identification - A method for sequencing a polynucleotide sample having a barcode sequence includes: introducing a series of nucleotides to the polynucleotide sample according to a predetermined order of nucleotide flows; obtaining a series of signals resulting from the introducing of nucleotides to the polynucleotide sample; and resolving the series of signals over the barcode sequence to render a flowspace string, wherein the flowspace string is a codeword of an error-correcting code that is (i) designed based on and adapted for use with the predetermined order of nucleotide flows, and (ii) capable of distinguishing any codeword in the error-correcting code from the other codewords in the error-correcting code in the presence of zero, one, and two errors. | 03-26-2015 |
Patent application number | Description | Published |
20080232657 | Feature Intensity Reconstruction of Biological Probe Array - The invention provides methods and systems for reconstructing feature intensities from pixel level data. In certain embodiments, the invention uses an empirically determined transfer function to construct a theoretical estimate of pixel level data and then iteratively updates feature intensities based on a minimum multiplicative error between the pixel level data and the theoretical estimate of the pixel level data. | 09-25-2008 |
20080287308 | SYSTEM, METHOD, AND COMPUTER SOFTWARE PRODUCT FOR GENOTYPE DETERMINATION USING PROBE ARRAY DATA - An embodiment of a method of analyzing data from processed images of biological probe arrays is described that comprises receiving a plurality of files comprising a plurality of intensity values associated with a probe on a biological probe array; normalizing the intensity values in each of the data files; determining an initial assignment for a plurality of genotypes using one or more of the intensity values from each file for each assignment; estimating a distribution of cluster centers using the plurality of initial assignments; combining the normalized intensity values with the cluster centers to determine a posterior estimate for each cluster center; and assigning a plurality of genotype calls using a distance of the one or more intensity values from the posterior estimate. | 11-20-2008 |
20110160092 | Methods for Selecting a Collection of Single Nucleotide Polymorphisms - The invention relates to the selection of a collection of relevant single nucleotide polymorphisms across a genome to design a nucleic acid probe array. As such, the invention relates to diverse fields impacted by the nature of genetics, including biology, medicine, and medical diagnostics. | 06-30-2011 |
20110274328 | Feature Intensity Reconstruction of Biological Probe Array - The invention provides methods and systems for reconstructing feature intensities from pixel level data. In certain embodiments, the invention uses an empirically determined transfer function to construct a theoretical estimate of pixel level data and then iteratively updates feature intensities based on a minimum multiplicative error between the pixel level data and the theoretical estimate of the pixel level data. | 11-10-2011 |
20110281772 | Methods, systems and computer software for designing and synthesizing sequence arrays - Embodiments of the invention provides methods, computer software products and systems for arranging polymers during combinatorial polymer synthesis so that the border or edge between synthesis site is minimized. In one embodiment, travelling salesman algorithm is used to minimize the edges. In another embodiment, a locally greedy optimization method is provided. In addition, methods and software products are provided for solving the robust arrangement problem for multi-probe gene expression arrays. | 11-17-2011 |
20120221255 | System, Method, and Computer Software Product for Genotype Determination Using Probe Array Data - An embodiment of a method of analyzing data from processed images of biological probe arrays is described that comprises receiving a plurality of files comprising a plurality of intensity values associated with a probe on a biological probe array; normalizing the intensity values in each of the data files; determining an initial assignment for a plurality of genotypes using one or more of the intensity values from each file for each assignment; estimating a distribution of cluster centers using the plurality of initial assignments; combining the normalized intensity values with the cluster centers to determine a posterior estimate for each cluster center; and assigning a plurality of genotype calls using a distance of the one or more intensity values from the posterior estimate. | 08-30-2012 |
20130059763 | System for photolithographic synthesis of polymer arrays - The present invention provides novel processes for the large scale preparation of arrays of polymer sequences wherein each array includes a plurality of different, positionally distinct polymer sequences having known monomer sequences. The methods of the invention combine high throughput process steps with high resolution photolithographic techniques in the manufacture of polymer arrays. | 03-07-2013 |
20130142408 | Feature Intensity Reconstruction of Biological Probe Array - The invention provides methods and systems for reconstructing feature intensities from pixel level data. In certain embodiments, the invention uses an empirically determined transfer function to construct a theoretical estimate of pixel level data and then iteratively updates feature intensities based on a minimum multiplicative error between the pixel level data and the theoretical estimate of the pixel level data. | 06-06-2013 |
20130150248 | Arrays of Nucleic Acid Probes for Analyzing Biotransformation Genes - The invention provides arrays of immobilized probes, and methods employing the arrays, for detecting mutations in the biotransformation genes, such as cytochromes P450. For example, one such array comprises four probe sets. A first probe set comprises a plurality of probes, each probe comprising a segment of at least three nucleotides exactly complementary to a subsequence of a reference sequence from a biotransformation gene, the segment including at least one interrogation position complementary to a corresponding nucleotide in the reference sequence. Second, third and fourth probe sets each comprise a corresponding probe for each probe in the first probe set. The probes in the second, third and fourth probe sets are identical to a sequence comprising the corresponding probe from the first probe set or a subsequence of at least three nucleotides thereof that includes the at least one interrogation position, except that the at least one interrogation position is occupied by a different nucleotide in each of the four corresponding probes from the four probe sets. | 06-13-2013 |
20150098637 | Feature Intensity Reconstruction of Biological Probe Array - The invention provides methods and systems for reconstructing feature intensities from pixel level data. In certain embodiments, the invention uses an empirically determined transfer function to construct a theoretical estimate of pixel level data and then iteratively updates feature intensities based on a minimum multiplicative error between the pixel level data and the theoretical estimate of the pixel level data. | 04-09-2015 |
Patent application number | Description | Published |
20100205027 | Business Driven Learning Solution Particularly Suitable for Sales-Oriented Organizations - Disclosed is a business driven learning solution and related methods for managing the learning and training needs of a sales-oriented organization in a manner that is responsive to dynamic business needs. The invention employs modules of interrelated and interdependent business processes for the identification and prioritization of learning needs, the selection of learning approaches, the development of learning content, the coordination and delivery of learning instruction, and the overall management and administration learning efforts. Embodiments of the inventions disclosed include sales training objects to provide a template for sales training that is focused on a solution, and how to position and sell the solution, rather than on the products that make up the solution. As a result, the sales force is educated, understands the customers' business requirements, and is able to craft specific value propositions to a given customer with respect to that solution. Thus, the training is customer-centric as opposed to product-centric. | 08-12-2010 |
20110264481 | BUSINESS DRIVEN LEARNING SOLUTION PARTICULARLY SUITABLE FOR SALES-ORIENTED ORGANIZATIONS - Disclosed is a business driven learning solution and related methods for managing the learning and training needs of a sales-oriented organization in a manner that is in responsive to dynamic business needs. The invention employs modules of interrelated and interdependent business processes for the identification and prioritization of learning needs, the selection of learning approaches, the development of learning content, the coordination and delivery of learning instruction, and the overall management and administration learning efforts. Embodiments of the inventions disclosed include sales training objects to provide a template for sales training that is focused on a solution, and how to position and sell the solution, rather than on the products that make up the solution. As a result, the sales force is educated, understands the customers' business requirements, and is able to craft specific value propositions to a given customer with respect to that solution. Thus, the training is customer-centric as opposed to product-centric. | 10-27-2011 |
Patent application number | Description | Published |
20110258015 | SYSTEM FOR PROVIDING WORKFORCE PLANNING SERVICES - A system is described for providing workforce planning services. The system may include a memory, an interface, and a processor. The memory may store a baseline dataset describing current employees of an organization. The processor may be operative to determine a projected workforce dataset based on the baseline dataset, the projected workforce dataset describing projected employees required by the organization. The processor may assess the baseline dataset and employee movement strategies to determine a forecasted available workforce dataset describing forecasted employees available to the organization. The processor may determine a gap between the projected workforce dataset and the forecasted available workforce dataset. The processor may generate a workforce service plan which describes strategies for eliminating the gap and may provide the plan to a user. The processor may receive updates to the baseline dataset and may assess the updates to determine whether the plan is being effectively implemented. | 10-20-2011 |
20110318716 | SYSTEM AND METHOD TO MEASURE EFFECTIVENESS OF BUSINESS LEARNING - The invention generally describes learning solutions and related methods for managing the learning and training needs of an organization in a manner that is responsive to dynamic business timelines, goals and strategic objectives. Business goals are determined through examination of existing business data sources, so as to tailor learning solutions to business impacts. Accurate computations of return on training investment are provided to allow accurate assessment of the effectiveness of training programs. Also disclosed are networks of learning platforms that together implement the learning solution by providing electronic tools and information sharing capabilities needed by a learning solution services provider to efficiently implement and manage learning efforts according to the business desires of a complex learner organization, while receiving organization performance data in order to compute and report performance measurements. | 12-29-2011 |
20150381770 | DATA PACKET DELIVERY BASED ON NETWORK DELIVERY REQUIREMENTS - A server device is provided that may format generated data packets to be compatible with network requirements for sending the data packets to a client device via a network. For example, the server device may generate the data packets for delivery to a client device via a network. The server device may determine downstream network requirements for delivering the data packets via the network. The downstream network requirements may indicate compliance with a particular network standard. The server device may identify a non-compliant data packet of the data packets that does not comply with the downstream network requirements. The server device may generate a formatted data packet by automatically formatting the non-compliant data packet to comply with the downstream network requirements. The formatted data packet may be generated based on the particular network standard. The server device may send the data packets, including the formatted data packet, to the client device via the network. | 12-31-2015 |