Spivak
Anna Yulievna Spivak, Ufa RU
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20090306413 | Method for preparing 2,5,7,8-tetramethyl-2-(2'-carboxyethyl)-6-acetoxyromane-precursor- alpha-cehc precursor - The contemplated invention relates to the field of synthesis of biologically active substances, namely to the synthesis of an acetate derivative of the main water-soluble α-tocopherol metabolite known under the name of α-CEHC, which is prepared by the acid-catalyzed reaction of condensation of trimethyl hydroquinone with linalool in boiling octane, using n-toluenesulfonic acid or (+)-camphor-10-sulfonic acid as the catalyst. The reaction is carried out for 3 hours at the trimethyl hydroquinone:linalool:catalyst mole ratio of 1:1:0.1. The forming product is acetylated with acetic anhydride in pyridine at room temperature for 0.5 hour, and then ozonized in acetone in the presence of Ba(OH) | 12-10-2009 |
Dina Spivak, Pardes-Harma IL
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20100081695 | 2-N-{5-[ [4-[2-(methyl-2-pyridinylamino) ethoxy] phenyl]methyl]-2,4-thiazolidinedione) butanedioic acid, methods of preparation and compositions with rosiglitazone maleate - Disclosed is an isolated compound of the formula: | 04-01-2010 |
Igor Spivak, Haifa IL
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20110229557 | METHODS FOR TREATING EYE DISORDERS - The present invention relates to compositions and methods for inhibiting loss of a retinal ganglion cell in a subject, comprising non-invasively applying to the surface of the eye of the subject an ophthalmic composition comprising a therapeutically effective amount of at 5 least one siRNA which down regulates expression of a target gene associated with loss of the retinal ganglion cell, thereby inhibiting loss of the retinal ganglion cell in the subject. The methods of the invention also relate to the use of chemically modified siRNA compounds possessing structural motifs which down-regulate the expression of human genes expressed in retinal tissue in the mammalian eye. | 09-22-2011 |
20120252875 | METHODS AND COMPOSITIONS FOR TREATING DISEASES, DISORDERS OR INJURY OF THE CNS - The present invention relates to non-invasive methods for treating diseases, disorders and injury to the central nervous system (CNS), and in particular to otic compositions and to methods of use thereof. | 10-04-2012 |
20150050328 | METHODS FOR TREATING EYE DISORDERS - The present invention relates to compositions and methods for inhibiting loss of a retinal ganglion cell in a subject, comprising non-invasively applying to the surface of the eye of the subject an ophthalmic composition comprising a therapeutically effective amount of at least one siRNA which down regulates expression of a target gene associated with loss of the retinal ganglion cell, thereby inhibiting loss of the retinal ganglion cell in the subject. The methods of the invention also relate to the use of chemically modified siRNA compounds possessing structural motifs which down-regulate the expression of human genes expressed in retinal tissue in the mammalian eye. | 02-19-2015 |
Igor Spivak, Jaifa IL
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20110142917 | COMPOSITIONS AND METHODS FOR TREATMENT OF EAR DISORDERS - The present invention relates to pharmaceutical compositions useful for topical, non-invasive delivery of an oligonucleotide to the ear and to methods for the treatment of an ear disorder, including hearing loss arising from chemical-induced ototoxicity, acoustic trauma and presbycusis; and microbial infections. The method comprises topically administering to the ear of a subject in need thereof a pharmaceutical composition comprising an inhibitory oligonucleotide, a permeability enhancer and a pharmaceutically acceptable carrier, wherein the oligonucleotide reduces or inhibits expression of a gene associated with the ear disorder in the subject. | 06-16-2011 |
20140066493 | COMPOSITIONS AND METHODS FOR TREATMENT OF EAR DISORDERS - The present invention relates to pharmaceutical compositions useful for topical, non-invasive delivery of an oligonucleotide to the ear and to methods for the treatment of an ear disorder, including hearing loss arising from chemical-induced ototoxicity, acoustic trauma and presbycusis; and microbial infections. The method comprises topically administering to the ear of a subject in need thereof a pharmaceutical composition comprising an inhibitory oligonucleotide, a permeability enhancer and a pharmaceutically acceptable carrier, wherein the oligonucleotide reduces or inhibits expression of a gene associated with the ear disorder in the subject. | 03-06-2014 |
Jonathan David L. Spivak, North York CA
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20150091395 | Electro-mechanical Reciprocating Magnetic Piston Engine - An electrical engine using a magnetic piston is disclosed. The magnetic piston is contained in a housing which has a passage through which the magnetic piston can freely reciprocate between opposite first and second ends. Electromagnets are mounted adjacent the ends of the passage, the electromagnets configured to generate a repulsive magnetic force onto the magnetic piston when activated. An electrical switch coupling each electromagnet to an electrical current source for activating the electromagnets, the electrical switches being positioned at the ends of the passage adjacent the electromagnets. The electrical switches configured to activate the electromagnets when the magnetic piston is positioned adjacent the switches. | 04-02-2015 |
20150091479 | Electric Vehicle Propulsion System Using Magnetic Piston Engine - An electrical vehicle propulsion system having dual electric magnetic piston engines is disclosed. The first magnetic piston engine is used to provide propulsive force to the vehicle while the second magnetic piston engine is used to drive a DC electric generator. The first and second electric piston engines are driven by current from a series of rechargeable batteries which are at least partially recharged by the DC electric generator. The recharging of the batteries being done via a battery controller which is configured to recharge the batteries cyclically such that while some batteries are drained to provide current for the electric magnetic piston engines, other batteries are recharged. | 04-02-2015 |
Josef Spivak, Netanya IL
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20150034569 | INTEGRATED UNIT FOR INTAKE AND PRETREATMENT WITH LOCAL BACKWASHING - Locally backwashing portions of filter media allows a simple and effective design of intake and pretreatment units, as well as their integration. An enclosure is used to limit portions of filter media and backwash them locally by suction, utilizing filtered water from adjacent filter media as the back wash water. Wastewater is produced at small amounts that allows efficient sludge treatment. This design enables water pretreatment at the intake unit, simplifying overall plant design and preventing damage to organisms living outside the intake unit. | 02-05-2015 |
Michael Spivak, Netania IL
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20090059788 | Method and Apparatus for Dynamic Adaptation of Network Transport - An intermediate device of a network includes network and transport layers, a dispatcher, a splitter and a connections database. The splitter intercepts a message packet in the network layer and modifies the network routing header and transport header of the message packet to form a modified message packet. The dispatcher receives modified message packets from the transport layer, recovers information from the message packets, passes the modified message packets back to the transport layer and adapts the transport layer to adapt communication dependent upon the information recovered from the message packets. The connections database stores the original source address, the original destination address, the original source port identifier and the original destination port identifier of an incoming message packet. A message packet is modified, with reference to the connections database, so that message packets from the first and second nodes are routed through the dispatcher. | 03-05-2009 |
Victor Spivak, Berlin DE
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20150190113 | OPTICAL-ACOUSTIC IMAGING DEVICE - The present invention is a guide wire imaging device for vascular or non-vascular imaging utilizing optic acoustical methods, which device has a profile of less than 1 mm in diameter. The ultrasound imaging device of the invention comprises a single mode optical fiber with at least one Bragg grating, and a piezoelectric or piezo-ceramic jacket, which device may achieve omnidirectional (360°) imaging. The imaging guide wire of the invention can function as a guide wire for vascular interventions, can enable real time imaging during balloon inflation, and stent deployment, thus will provide clinical information that is not available when catheter-based imaging systems are used. The device of the invention may enable shortened total procedure times, including the fluoroscopy time, will also reduce radiation exposure to the patient and to the operator. | 07-09-2015 |