Patent application number | Description | Published |
20080227862 | Methods of treating cancer with HDAC inhibitors - The present invention relates to methods of treating cancers, e.g., leukemia. More specifically, the present invention relates to methods of treating acute and chronic leukemias including Acute Lymphocytic Leukemia (ALL), Acute Myeloid Leukemia (AML), Chronic Lymphocytic leukemia (CLL), Chronic myeloid leukemia (CML) and Hairy Cell Leukemia, by administration of pharmaceutical compositions comprising HDAC inhibitors, e.g., suberoylanilide hydroxamic acid (SAHA). The oral formulations of the pharmaceutical compositions have favorable pharmacokinetic profiles such as high bioavailability and surprisingly give rise to high blood levels of the active compounds over an extended period of time. The present invention further provides a safe, daily dosing regimen of these pharmaceutical compositions, which is easy to follow, and which results in a therapeutically effective amount of the HDAC inhibitors in vivo. | 09-18-2008 |
20080249179 | Methods of treating cancer with HDAC inhibitors - The present invention relates to methods of treating cancers, e.g., leukemia. More specifically, the present invention relates to methods of treating acute and chronic leukemias including Acute Lymphocytic Leukemia (ALL), Acute Myeloid Leukemia (AML), Chronic Lymphocytic leukemia (CLL), Chronic myeloid leukemia (CML) and Hairy Cell Leukemia, by administration of pharmaceutical compositions comprising HDAC inhibitors, e.g., suberoylanilide hydroxamic acid (SAHA). The oral formulations of the pharmaceutical compositions have favorable pharmacokinetic profiles such as high bioavailability and surprisingly give rise to high blood levels of the active compounds over an extended period of time. The present invention further provides a safe, daily dosing regimen of these pharmaceutical compositions, which is easy to follow, and which results in a therapeutically effective amount of the HDAC inhibitors in vivo. | 10-09-2008 |
20090012175 | Methods of treating cancer with HDAC inhibitors - The present invention provides methods of treating cancers, chemoprevention, selectively inducing terminal differentiation, cell growth arrest and/or apoptosis of neoplastic cells, and/or inhibiting histone deacetylase (HDAC) by administration of pharmaceutical compositions comprising potent HDAC inhibitors. The oral bioavailability of the active compounds in the pharmaceutical compositions of the present invention is surprisingly high. Moreover, the pharmaceutical compositions unexpectedly give rise to high, therapeutically effective blood levels of the active compounds over an extended period of time. The present invention further provides a safe, daily dosing regimen of these pharmaceutical compositions, which is easy to follow, and which results in a therapeutically effective amount of the HDAC inhibitors in vivo. | 01-08-2009 |
20100273732 | COMBINATION METHODS OF TREATING CANCER - The present invention relates to a method of treating cancer in a subject in need thereof, by administering to a subject in need thereof a first amount of a histone deacetylase (HDAC) inhibitor or a pharmaceutically acceptable salt or hydrate thereof, in a first treatment procedure, and a second amount of an anti-cancer agent in a second treatment procedure. The first and second amounts together comprise a therapeutically effective amount. The effect of the HDAC inhibitor and the anti-cancer agent may be additive or synergistic. | 10-28-2010 |
Patent application number | Description | Published |
20090056440 | ADJUSTABLE MEASURING CUP - Adjustable measuring cups include a housing having a peripheral wall having an open upper end, an outer surface, an inner surface, and a bottom surface. The adjustable measuring cups also include a platform slidably movable within the housing, and an adjustment wheel rotatably connected to the bottom surface of the housing. The platform has an upper surface and a lower surface. A plurality of connecting rods can be connected to the adjustment wheel, and can also be connected to the lower surface of the platform. The measuring volume of an adjustable measuring cup can be defined by the open upper end, the inner surface of the housing and the upper surface of the platform. The platform slidably moves when the adjustment wheel is rotated, thereby adjusting the measuring volume of the measuring cup. | 03-05-2009 |
20090059715 | PASTRY BLENDER - A pastry blender that includes a handle, a plurality of arcuate cutting wires attached to the handle, and a plurality of arcuate blending wires that are also attached to the handle. The pastry blender can also include a scraper that removably connects to the cutting wires and the blending wires. | 03-05-2009 |
20090294310 | CAKE DECORATING ORGANIZER - A cake decorating organizer with multiple compartments is provided for storing cake decorating tools. The cake decorating organizer has a lower case section, a middle case section and an upper case section. The upper case section has at least one recessed storage area, preferably with a lid connected thereto. In preferred embodiments, decorating tips of various sizes can be stored in the recessed storage area of the upper case section. The middle and lower case sections each have at least one drawer slidably received therein. Preferably, the cake decorating organizer also has at least one side pocket for storing spatulas. | 12-03-2009 |
Patent application number | Description | Published |
20160101139 | TOPICAL TREATMENT FOR USE AS A SLEEP AID - The present invention relates to a homeopathic sleep aid composition that may be applied topically. A composition may contain a synergistic blend of snake venom and relaxation-inducing herbs. A composition may facilitate relaxation by acting like an antihistamine, a GABA modulator, or an aromatherapeutic compound. A homeopathic composition may be applied topically on any part of the skin and even on open wounds. A homeopathic composition may also be formulated in an oral composition or intranasal composition. A homeopathic composition may aid people who have or do not have pain to fall asleep and stay asleep. | 04-14-2016 |
20160101141 | Topical Treatment of Sports Related Injuries - The present invention relates to a homeopathic composition that may be used as a pain management treatment of musculoskeletal injuries. More particularly, the present disclosure and claims provide a treatment for sports related injuries (SRIs). In particular, the present invention provides a topical application, such as a cream or gel, which may be applied on or into the skin, wherein the topical application comprises one or more a vasodilator, stimulator of lymphatic activity, or mobilizers. Preferred embodiments include ingredients derived from natural sources, and in some aspects, natural sources processed through homeopathic steps. Homeopathic steps may include, for example, filtration and dilution. | 04-14-2016 |
20160106797 | TOPICAL TREATMENT OF SHINGLES - The present invention relates to a homeopathic composition that may be used for treatment of chronic moderate to severe pain associated with virally driven neuropathies. More particularly, the present disclosure and claims provide a treatment of the pain symptoms of shingles, herpes zoster. In some embodiments, the application of the homeopathic composition may reduce length of the outbreak, severity of symptoms, and long term effects, such as nerve damage or skin discoloration. | 04-21-2016 |
20160106798 | TOPICAL TREATMENT FOR USE IN CONJUNCTION WITH ACUPUNCTURE OR ACUPRESSURE THERAPY - The present invention relates to a topical application of a homeopathic composition to the skin to be used as an enhancement for acupuncture and acupressure. The composition may be in the form of an ointment, cream, gel, or salve. The composition may be applied before, during, and after acupressure or acupuncture. The composition may contain snake venom along with a synergistic blend of vasodilator and analgesic herbs that relieve pain by stimulating blood flow and reducing edema. The composition complements the Chinese medicine theory of balancing the body's energy flow. | 04-21-2016 |