Patent application number | Description | Published |
20090240751 | Text-based calculator for dimensional computations - The present invention relates to tools that handle and perform computations using dimensional and dimensionless values, automatically converting them appropriately within equations, outputting answers in default or user-selected output units, and indicating when inconsistencies or errors are present in the input so that these can be quickly and easily identified and immediately corrected. More particularly, it relates to improved, computer-based systems, methods and software for automatically changing between different units, correctly computing formulas using dimensional values, and outputting the results in arbitrary dimensionally consistent units. The current embodiments accomplish these objectives with as much simplicity, as flexible a syntax, as little typing, and with as little chance of human error as possible. | 09-24-2009 |
20130304671 | Factor Risk Models with Multiple Specific Risk Estimates - Construction of factor risk models that more advantageously predict the future volatility of returns of a portfolio of securities such as stocks, bonds, or the like is addressed. More specifically, factor risk models with more than one estimate of specific risk or, alternatively an original specific risk estimate together with a set of specific risk differences derived from more than one estimate of specific risk. | 11-14-2013 |
20130332391 | Methodology and Process For Constructing Factor Indexes - Approaches to the construction of indexes are addressed wherein a portfolio of securities such as stocks, bonds, or the like and their associated investment weights or shares is generated. Indexes can be used as investment tools in various ways. For instance, indexes comprising a plurality of securities can often be bought and sold more cheaply than buying and selling the individual constituents of the index. This pricing differential allows investment with reduced transaction costs. Alternatively, in passive and enhanced indexing, investments are made with reference to an index. Performance statistics such as return and risk are reported with respect to the reference index. Factor indexes can serve as active manager benchmarks or the underlyers for investable products such as exchange traded funds and mutual funds. Computer based systems, methods and software are addressed for constructing indexes that replicate the returns of a quantitative factor such as medium term momentum or value. Further, processes and methodology are described by which the index can have the best possible replication of the underlying factor returns as well as other desirable characteristics. The methodology provides an approach to determine the index even when all desirable characteristics of the index are not simultaneously achievable. | 12-12-2013 |
20140081889 | Purifying Portfolios Using Orthogonal Non-Target Factor Constraints - The quantitative construction of investment portfolios of securities such as stocks, bonds, or the like using optimization is addressed. More specifically, during optimization constraints on non-target factor exposures are automatically converted to constraints on the exposure of the projections of the non-target factors that are orthogonal to a specified target factor. Such constraints may be utilized to produce portfolios with superior performance to those produced with traditional factor exposure constraints. | 03-20-2014 |
20140108295 | Methods and Apparatus for Generating Purified Minimum Risk Portfolios - The quantitative construction of investment portfolios of securities such as stocks, bonds, or the like using optimization is addressed. More specifically, during optimization, constraints on non-target factor exposures are automatically converted to constraints on the exposure of the projections of the non-target factors that are orthogonal to a specified target factor. The target factor may be the implied alpha of a reference portfolio, such as a traditional minimum risk portfolio. Such constraints may be utilized to produce portfolios with superior performance to those produced with traditional factor exposure constraints. | 04-17-2014 |
20150254226 | Spreadsheet Tool for Dimensional Calculations - Spreadsheet-based tools for converting dimensional quantities from one set of dimensional units to another quickly and efficiently as well as correctly and automatically performing mathematical calculations using dimensional and dimensionless quantities are described. More particularly, the computer-based systems, methods and spreadsheet software perform mathematical calculations with both dimensional and dimensionless quantities, allowing extensive flexibility and customization so that both the user input and the computer output use the units that are most useful and convenient. | 09-10-2015 |
Patent application number | Description | Published |
20080241096 | IL-1 family variants - The present invention provides compositions and methods relating to IL-1Rrp2 requiring proteins. | 10-02-2008 |
20090232816 | IL-1 ETA DNA AND POLYPEPTIDES - The invention is directed to novel purified and isolated IL-1 eta polypeptides and fragment thereof, the polynucleotides encoding such, polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, peptides derived from these polypeptides, and uses thereof. | 09-17-2009 |
20120020918 | IL-1 FAMILY VARIANTS - The present invention provides compositions and methods relating to IL-1Rrp2 requiring proteins. | 01-26-2012 |
20130336926 | IL-1 FAMILY VARIANTS - The present invention provides compositions and methods relating to IL-1Rrp2 requiring proteins. | 12-19-2013 |
20150017123 | IL-1 FAMILY VARIANTS - The present invention provides compositions and methods relating to IL-1Rrp2 requiring proteins. | 01-15-2015 |
Patent application number | Description | Published |
20090240751 | Text-based calculator for dimensional computations - The present invention relates to tools that handle and perform computations using dimensional and dimensionless values, automatically converting them appropriately within equations, outputting answers in default or user-selected output units, and indicating when inconsistencies or errors are present in the input so that these can be quickly and easily identified and immediately corrected. More particularly, it relates to improved, computer-based systems, methods and software for automatically changing between different units, correctly computing formulas using dimensional values, and outputting the results in arbitrary dimensionally consistent units. The current embodiments accomplish these objectives with as much simplicity, as flexible a syntax, as little typing, and with as little chance of human error as possible. | 09-24-2009 |
20150254226 | Spreadsheet Tool for Dimensional Calculations - Spreadsheet-based tools for converting dimensional quantities from one set of dimensional units to another quickly and efficiently as well as correctly and automatically performing mathematical calculations using dimensional and dimensionless quantities are described. More particularly, the computer-based systems, methods and spreadsheet software perform mathematical calculations with both dimensional and dimensionless quantities, allowing extensive flexibility and customization so that both the user input and the computer output use the units that are most useful and convenient. | 09-10-2015 |
Patent application number | Description | Published |
20110049489 | Top-Gate Bottom-Contact Organic Transistor - Top-gate, bottom-contact organic thin film transistors are provided. The transistors may include metal bilayer electrodes to aid in charge movement within the device. In an embodiment, an organic transistor includes a drain electrode and a source electrode disposed over a first region of a substrate, a transition metal oxide layer disposed over and in direct physical contact with the drain electrode and the source electrode, an organic preferentially hole conducting channel layer disposed over the metal oxide and between the drain electrode and the source electrode, and a gate electrode disposed over the channel. | 03-03-2011 |
20120218719 | System and Method of Forming Semiconductor Devices - Systems and methods including bonding two or more separately formed circuit layers are provided using, for example, cold welding techniques. Processing techniques may be provided for combining inorganic and/or organic semiconductor devices in apparatus including, for example, microchips, optoelectronic devices, such as solar cells, photodetectors and organic light emitting diodes (OLEDs), and other apparatus with multi-layer circuitry. Methods of bonding preformed circuit layers may include the use of stamping and pressure bonding contacts of two or more circuit layers together. Such methods may find applicability, for example, in bonding circuitry to shaped substrates, including various rounded and irregular shapes, and may be used to combine devices with different structural properties, e.g. from different materials systems. | 08-30-2012 |
20130001731 | Non-Planar Inorganic Optoelectronic Devices - A method of fabricating an optoelectronic device includes creating an optoelectronic structure on a first substrate. The optoelectronic structure includes a release layer and a plurality of inorganic semiconductor layers supported by the release layer. The plurality of inorganic semiconductor layers is configured to be active in operation of the optoelectronic device. The plurality of inorganic semiconductor layers are permanently attached to a second substrate, which is flexible. The plurality of inorganic semiconductor layers are released from the first substrate after the attaching step, and the second substrate is deformed to a non-planar configuration. | 01-03-2013 |
Patent application number | Description | Published |
20080281922 | AUTOMATIC GENERATION OF EMAIL PREVIEWS AND SUMMARIES - An incoming electronic communication is broken down into message portions. Features of the message portions are extracted and the message portions are converted into sparse feature vectors. The probabilities of the message portions being of interest of the user are calculated and the message portions are converted back into text. Message portions with a relatively high probability of being of interest to a user are presented to the user as a summary. | 11-13-2008 |
20120014596 | ADAPTIVE COMPRESSION OF MULTI-LEVEL IMAGES - The invention facilitates adaptive compression of multi-level images, such as captured digital images of a whiteboard, etc., encoding a bitstream comprising a color image component and a black-and-white image component. Either or both of a color and a black-and-white image can be output to a user based on user desires, receiving device capabilities, etc. | 01-19-2012 |
20130121574 | ADAPTIVE COMPRESSION OF MULTI-LEVEL IMAGES - The invention facilitates adaptive compression of multi-level images, such as captured digital images of a whiteboard, etc., encoding a bitstream comprising a color image component and a black-and-white image component. Either or both of a color and a black-and-white image can be output to a user based on user desires, receiving device capabilities, etc. | 05-16-2013 |
Patent application number | Description | Published |
20090011471 | Engineered plasmids and their use for in situ production of genes - Nucleic acid sequences encoding at least a portion of a polypeptide are directly incorporated into a plasmid by DNA polymerization or reverse transcription of a nucleic acid template. In particularly preferred embodiments, nucleic acid sequences encoding at least a portion of an antibody are directly incorporated into a plasmid by reverse transcription of messenger RNA (mRNA). | 01-08-2009 |
20090130716 | Rationally designed antibodies - Antibodies or fragments thereof having at least two CDR regions replaced or fused with biologically active peptides are described. Compositions containing such antibodies or fragments thereof are useful in therapeutic and diagnostic modalities. | 05-21-2009 |
20100041012 | Rationally designed antibodies - Antibodies or fragments thereof having CDR regions replaced or fused with biologically active peptides are described. Flanking sequences may optionally be attached at one or both the carboxy-terminal and amino-terminal ends of the peptide in covalent association with adjacent framework regions. Compositions containing such antibodies or fragments thereof are useful in therapeutic and diagnostic modalities. | 02-18-2010 |
20100105620 | Polypeptides that bind Trail-R1 and Trail-R2 - Agonists for TRAIL death receptors including polypeptides having a multimerizing, e.g. trimerizing, domain and a polypeptide sequence that binds to at least one of TRAIL death receptors TRAIL-R1 and TRAIL-R2. Agonists are described that do not bind to TRAIL decoy receptors. The multimerizing domain may be derived from human tetranectin. The agonists can induce apoptosis in pathogenic cells expressing a TRAIL death receptor. Pharmaceutical compositions are described for treating diseases associated with cells expressing DR4 and DR5, such as tumor cells. Methods for selecting polypeptides and preparing multimeric complexes. | 04-29-2010 |
20110086770 | Combinatorial Libraries Based on C-type Lectin-like Domain - This invention relates to polypeptide libraries comprising polypeptides having a C-type lectin domain (CTLD) with a randomized loop region, as well as nucleic acid libraries comprising nucleic acid molecules encoding such polypeptides. The invention also relates to methods for generating the randomized polypeptides and the polypeptide libraries. The invention further relates to methods of screening the polypeptide and nucleic acid libraries based on the specific binding of the modified CTLDs to a target molecule of interest. The invention also relates to polypeptides derived from such libraries that bind to target molecules of interest. | 04-14-2011 |
20120021995 | Polypeptides that Bind TRAIL-R1 and TRAIL-R2 - Agonists for TRAIL death receptors including polypeptides that bind to TRAIL death receptor TRAIL-R1 (DR4) and/or TRAIL-R2 (DR5) and optionally having a multimerizing, e.g. trimerizing domain. Agonists are described that do not bind to TRAIL decoy receptors. The multimerizing domain may be derived from human tetranectin. The agonists can induce apoptosis in pathogenic cells expressing a TRAIL death receptor. Pharmaceutical compositions are described for treating diseases associated with cells expressing DR4 and DR5, such as tumor cells. Methods for selecting polypeptides and preparing multimeric complexes. | 01-26-2012 |
20120135938 | Polypeptides that Bind TRAIL-R1 and TRAIL-R2 - Agonists for TRAIL death receptors including polypeptides having a multimerizing, e.g. trimerizing, domain and a polypeptide sequence that binds to at least one of TRAIL death receptors TRAIL-R1 and TRAIL-R2. Agonists are described that do not bind to TRAIL decoy receptors. The multimerizing domain may be derived from human tetranectin. The agonists can induce apoptosis in pathogenic cells expressing a TRAIL death receptor. Pharmaceutical compositions are described for treating diseases associated with cells expressing DR4 and DR5, such as tumor cells. Methods for selecting polypeptides and preparing multimeric complexes. | 05-31-2012 |
Patent application number | Description | Published |
20090054370 | PYRIMIDINES, SUCH AS URIDINE, IN TREATMENTS FOR PATIENTS WITH BIPOLAR DISORDER - The invention is based on the discovery that specific dosages of pyrimidine compositions, such as uridine compositions, can be used to treat patients diagnosed with bipolar disorder. | 02-26-2009 |
20090215714 | Pyrimidines, such as cytidine, in treatments for patients with biopolar disorder - The invention is based on the discovery that specific dosages of pyrimidine compositions, such as cytidine compositions, can be used to treat patients diagnosed with bipolar disorder. | 08-27-2009 |
20100041620 | METHODS FOR IMPROVING FRONTAL BRAIN BIOENERGETIC METABOLISM - The invention provides methods and compositions for augmenting bioenergetic metabolism in the frontal brain involving administration of a cytidine-containing or uridine-containing compound to a human. | 02-18-2010 |
20100041621 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE PERFORMANCE - The invention provides methods and compositions for improving cognitive performance involving administration of a cytidine-containing or uridine-containing compound to a neuropsychologically healthy human. | 02-18-2010 |
20100094120 | PREDICTING EFFICACY OF PSYCHIATRIC TREATMENT - Methods and systems are described for determining, in a patient that suffers from a mood disorder (e.g., depression), a propensity of the patient to manifest reduced symptoms or levels of indicators of the mood disorder in response to a psychiatric treatment. This can involve determining levels of a marker (e.g., a metabolite) indicative of a brain bioenergetic state of the patient that is predictive of whether the patient will response favorably to an antidepression treatment. Such bioenergetic state markers, tending to normalize in response to antidepression therapy, can include, e.g., a pH, a magnesium level, and a phosphorus level. Brain levels of such markers can be determined by, e.g., | 04-15-2010 |
20100222296 | PYRIMIDINES, SUCH AS URIDINE, IN TREATMENTS FOR PATIENTS WITH BIPOLAR DISORDER - The invention is based on the discovery that specific dosages of pyrimidine compositions, such as uridine compositions, can be used to treat patients diagnosed with bipolar disorder. | 09-02-2010 |
Patent application number | Description | Published |
20080300214 | Compounds for the Treatment of Marihuana Dependence, Withdrawal, and Usage - The invention provides methods for treating or suppressing marihuana usage, withdrawal, or dependence involving administration of a therapeutically-effective amount of a cytosine-containing or cytidine-containing compound, uridine-containing compound, creatine-containing compound, adenosine-containing, or adenosine-elevating compound to a mammal. | 12-04-2008 |
20100197628 | METHODS OF TREATING PSYCHIATRIC, SUBSTANCE ABUSE, AND OTHER DISORDERS USING COMBINATIONS CONTAINING OMEGA-3 FATTY ACIDS - The invention provides methods for treating or preventing psychiatric disorders, substance abuse disorders, and other conditions, e.g., cardiovascular disease and cancer, involving administration of a therapeutically-effective amount of a cytosine-containing or cytidine-containing compound, creatine-containing compound, adenosine-containing, adenosine-elevating compound, omega-3 fatty acids, or combinations thereof to a mammal. The invention further provides methods of enhancing neurodevelopment and delaying premature pregnancy by administration of an effective amount of a cytosine-containing or cytidine-containing compound, creatine-containing compound, adenosine-containing, adenosine-elevating compound, omega-3 fatty acids, or combinations thereof to a mammal. | 08-05-2010 |