Patent application number | Description | Published |
20090192112 | COMPOSITIONS AND METHODS FOR TREATING CANCER - The present invention relates to therapeutic targets for cancer. In particular, the present invention relates to small molecules and nucleic acids that target ATDC (TRIM29) expression in cancer with ATDC overexpression. | 07-30-2009 |
20090317856 | Multimodal Spectroscopic Systems and Methods for Classifying Biological Tissue - Multimodal optical spectroscopy systems and methods produce a spectroscopic event to obtain spectroscopic response data from biological tissue and compare the response data with preset criteria configured to correlate the measured response data and the most probable attributes of the tissue, thus facilitating classification of the tissue based on those attributes for subsequent biopsy or remedial measures as necessary. | 12-24-2009 |
20100330611 | Multimodal Spectroscopic Systems and Methods for Classifying Biological Tissue - Multimodal optical spectroscopy systems and methods produce a spectroscopic event to obtain spectroscopic response data from biological tissue and compare the response data with an empirical equation configured to correlate the measured response data and the most probable attributes of the tissue, thus facilitating classification of the tissue based on those attributes for subsequent biopsy or remedial measures as necessary. | 12-30-2010 |
20120070368 | Methods of Using C-Met Modulators - Disclosed are methods of treating cancer by administering a compound of Formula I, | 03-22-2012 |
20120245473 | MULTIMODAL SPECTROSCOPIC SYSTEMS AND METHODS FOR CLASSIFYING BIOLOGICAL TISSUE - Multimodal optical spectroscopy systems and methods produce a spectroscopic event to obtain spectroscopic response data from biological tissue, either ex vivo or in vivo, and compare the response data with a model configured to correlate the measured response data and the most probable attributes of the tissue, thus facilitating classification of the tissue based on those attributes. | 09-27-2012 |
20130005598 | Methods for Diagnosing The Malignant Potential of Pancreatic Cystic Lesions - A method of diagnosing the malignant potential of a pancreatic cystic lesion in a subject including: detecting a glycan alteration in MUC5AC in a sample of pancreatic cystic lesion fluid from a subject, determining whether the glycan alteration is differentially present in the sample, and diagnosing the malignant potential of the pancreatic cystic lesion. A method of diagnosing the malignant potential of a pancreatic cystic lesion in a subject including: (a) detecting a glycan alteration in MUC5AC in a sample of pancreatic cystic lesion fluid from a subject, (b) detecting CA 19-9 in the sample, (c) determining whether the glycan alteration and CA 19-9 are differentially present in the sample, and (d) diagnosing the malignant potential of the pancreatic cystic lesion. Related methods of treatment and kits also are included. | 01-03-2013 |
20150202196 | Methods of Using C-Met Modulators - Disclosed are methods of treating cancer by administering a compound of Formula I, | 07-23-2015 |
Patent application number | Description | Published |
20080261244 | Compositions And Methods For Treating And Diagnosing Pancreatic Cancer - The present invention relates to the field of oncology and provides novel compositions and methods for diagnosing and treating pancreatic cancer. In particular, the present invention provides pancreatic cancer stem cells useful for the study, diagnosis, and treatment of solid tumors. | 10-23-2008 |
20090136960 | METHODS AND COMPOSITIONS FOR THE IDENTIFICATION OF CANCER MARKERS - The present invention relates to methods and compositions for the identification of cancer markers. In particular, the present invention provides methods and compositions for the identification of glycosylated proteins and protein glycosylation patterns. The present invention further provides cancer markers identified using the described methods. | 05-28-2009 |
20110092452 | COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING PANCREATIC CANCER - The present invention provides compositions and methods for treating and diagnosing the presence of solid tumor stem cells in a patient (e.g., based on the presence of c-Met). In certain embodiments, the presence or absence of solid tumor stem cells (e.g., pancreatic solid tumor stem cells) can be determined through the use of a single cells surface marker (e.g., c-Met). The present invention also provides methods for screening candidate compounds (e.g., c-Met antagonists) for the ability to inhibit the tumorigenisis of pancreatic solid tumor stem cells. | 04-21-2011 |
20110236993 | PANCREATIC CANCER MARKERS - The present invention relates to pancreatic cancer markers. In particular, the present invention provides methods and compositions for the identification of protein glycosylation patterns associated with pancreatic cancer. | 09-29-2011 |
20120135416 | Compositions And Methods For Treating And Diagnosing Pancreatic Cancer - The present invention relates to the field of oncology and provides novel compositions and methods for diagnosing and treating pancreatic cancer. In particular, the present invention provides pancreatic cancer stem cells useful for the study, diagnosis, and treatment of solid tumors. | 05-31-2012 |
20150293010 | Microfluidic Device And Method For Detecting Rare Cells - A microfluidic device for detecting rare cells in a fluid sample comprises the rare cell and other cells. The microfluidic device comprises an inlet for receiving the fluid sample, a labyrinth channel structure in fluid communication with the inlet, and an outlet in fluid communication with the labyrinth channel structure for collecting the rare cells separated from the other cells in the fluid sample. The labyrinth channel structure comprises at least one channel through which the fluid sample flows. The at least one channel has a plurality of segments and a plurality of corners with each corner defined between adjacent segments. The presence of the plurality of corners induces separation of the rare cells from the other cells in the fluid sample as the rare cells move to a first equilibrium position within the at least one channel when a ratio of inertial lift forces (F | 10-15-2015 |
20150330967 | COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING PANCREATIC CANCER - The present invention provides compositions and methods for treating and diagnosing the presence of solid tumor stem cells in a patient (e.g., based on the presence of c-Met). In certain embodiments, the presence or absence of solid tumor stem cells (e.g., pancreatic solid tumor stem cells) can be determined through the use of a single cells surface marker (e.g., c-Met). The present invention also provides methods for screening candidate compounds (e.g., c-Met antagonists) for the ability to inhibit the tumorigenisis of pancreatic solid tumor stem cells. | 11-19-2015 |
Patent application number | Description | Published |
20090053039 | Single Piece Nozzle Cover Design and Method of Manufacture - A blower wheel housing for an air conditioning system is formed of a single molded element having a base section and a nozzle section with included vanes having complex shapes. This is accomplished by employing a pair of mold core elements which together form a cavity into which a plastic material is injected to form the cover with its integral nozzle and vanes, and the mold core elements are then withdrawn in opposite directions but at an angle to the direction normal to the two mold core elements to thereby accommodate the complex shapes of the vanes. In one embodiment, the top wall of the nozzle is disposed at an acute angle to the longitudinal plane of the cover, and the mold core elements are also withdrawn in a plane that is parallel to this wall. | 02-26-2009 |
20090211287 | MODULAR CONDENSER FAN ASSEMBLY - A modular condenser fan/motor assembly for use in a transport refrigeration system includes a support frame, a fan shroud panel, a fan/motor assembly and a support bracket. A fan and motor assembly for use in a transport refrigeration unit includes a fan impeller disposed about an inside/out motor, whereby the fan impeller rotates with at least a portion of an outer casing of the motor. | 08-27-2009 |
20090211288 | COMBINATION MICROCHANNEL CONDENSER AND RADIATOR MOUNTING ARRANGEMENT - A transport refrigeration system includes a single frame for containing both a refrigeration condenser coil and an engine coolant radiator arranged in serial airflow relationship within a framework. Either one or the other may be removed and replaced without replacing the other. | 08-27-2009 |
20100162743 | COMPOSITE DOORS FOR TRANSPORT REFRIGERATION UNIT - The front cover of a transport refrigeration unit includes a plurality of hinged access doors, with each door being formed of a pair of spaced thermoplastic olefin sheets with their edges being bonded along the entire periphery of the door to form a hollow space between the sheets without a need for foam. The edges are bonded by a thermoforming process which provides strength and rigidity to the door. Additional thermoforming bonds are made at locations other than the periphery to provide further strength and rigidity. A ribbing structure is formed in one of the sheets and extends around the periphery thereof. Further ribbing may extend transversely across the sheet in non-peripheral positions. | 07-01-2010 |
Patent application number | Description | Published |
20120118917 | POWERED DISPENSING TOOL - A powered dispensing tool includes a housing, a motor positioned within the housing, a rack coupled to the motor for powered translation in at least one of a forward direction and a reverse direction, and a transmission selectively coupling the motor and the rack. The transmission includes an input ring rotatable in response to rotation of the motor in a first direction corresponding with powered translation of the rack in the forward direction, a first clutch member engaged with the rack through an intermediate gear, and a second clutch member that receives torque from the input ring and that is movable in response to rotation of the motor in the first direction toward a first position engaging the first clutch member. The second clutch member is also movable in response to rotation of the motor in an opposite, second direction toward a second position disengaged from the first clutch member. | 05-17-2012 |
20130068073 | FASTENER DRIVER AND EXTENSION - A fastener driver configured for use with a rotary power tool having a chuck. The fastener driver includes a drive including a shank, an elongated extension including an aperture that extends through the elongated extension, and the drive is removably coupled to the elongated extension. The fastener driver further includes a driver including an aperture that extends through the driver and a drive to engage a fastener to rotate the fastener, and the driver is removably coupled to elongated extension to allow the fastener to pass through the aperture of the driver and into the aperture of the elongated extension. The fastener driver further includes a connector that couples the driver to the drive for co-rotation without the elongated extension when the elongated extension is not utilized and the connector couples the driver, the elongated extension, and the drive for co-rotation when the elongated extension is utilized. | 03-21-2013 |
20140262389 | POWER TOOL OPERATION RECORDING AND PLAYBACK - A power tool and method for recording and playing back a motor parameter. The power tool includes housing, a motor, a trigger, a mode selector switch, and a controller. The trigger outputs an activation signal based on a user input. The mode selector switch is configured to receive a user mode selection indicating a recording mode, a normal operating mode, or a playback mode. The controller receives a mode selection signal from the mode selector switch indicating the selected mode. The controller enters the recording mode when the user mode selection indicates the recording mode, and records a motor parameter while the power tool is in the recording mode to generate a recorded motor parameter. In the playback mode, the controller operates the motor based on the recorded motor parameter upon receiving the activation signal from the trigger. | 09-18-2014 |