Patent application number | Description | Published |
20100010041 | DIFLUORINATED PIPERIDINES FOR TREATMENT OF ALZHEIMER'S DISEASE AND RELATED CONDITIONS - Compounds of formula (I). Selectively inhibit production of Aβ(1-42) and hence find use in treatment of diseases associated with deposition of β-amyloid in the brain. | 01-14-2010 |
20100093665 | SILYLATED PIPERIDINE DERIVATIVES - Compounds of formula I: I wherein at least one of R4 and R5 comprises Si(R6)3 as a substituent selectively attenuate production of Aβ(1-42) and hence find use in treatment of Alzheimer's disease and related conditions. | 04-15-2010 |
20100204230 | PIPERAZINE DERIVATIVES FOR TREATMENT OF AD AND RELATED CONDITIONS - Compounds of formula (I) selectively inhibit production of Aβ(1-42) and hence find use in treatment of Alzheimer's disease and other conditions associated with deposition of A(β) in the brain. | 08-12-2010 |
20110039925 | CYCLOBUTYL SULFONES AS NOTCH SPARING GAMMA SECRETASE INHIBITORS - The invention encompasses a novel class of cyclobutyl sulfone derivatives which inhibit the processing of APP by the putative γ-secretase while sparing Notch signaling pathway, and thus are useful in the treatment or prevention of Alzheimer's disease without the development of Notch inhibition mediated gastrointestinal issues. Pharmaceutical compositions and methods of use are also included. | 02-17-2011 |
20110251172 | PURINE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE - The invention encompasses purine derivatives as gamma secretase modulators, useful for treating diseases associated with the deposition of beta-amyloid peptide in the brain, such as Alzheimer's disease, or of preventing or delaying the onset of dementia associated with such diseases. Pharmaceutical compositions and methods of use are included. | 10-13-2011 |
20130338092 | COMPOUNDS AND METHODS FOR TARGETING LEUKEMIC STEM CELLS - This invention relates to high-throughput, semi-automated methods for identifying compounds that are effective in targeting leukemia stem cells, as well as compounds identified by those methods and uses thereof for treating leukemia. | 12-19-2013 |
20140045860 | SMALL MOLECULE INHIBITORS FOR TREATING PARASITIC INFECTIONS - The invention relates to a compound of Formula I or a pharmaceutically acceptable ester, salt, prodrug or metabolite thereof; | 02-13-2014 |
20140100223 | COMPOUNDS AND METHODS FOR THE TREATMENT OF ISOCITRATE DEHYDROGENASE RELATED DISEASES - The invention relates to compounds of Formula I or a pharmaceutically acceptable salt, ester or prodrug thereof: | 04-10-2014 |
20140107141 | KINASE INHIBITORS AND METHODS OF USE THEREOF - The present invention provides compounds of formula I, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting kinase (e.g., GSK3 (e.g., GSK3α or GSK3β) or CK1) activity. The present invention further provides methods of using the compounds described herein for treating kinase-mediated disorders, such as neurological diseases, psychriatic disorders, metabolic disorders, and cancer. | 04-17-2014 |