Kaarel
Kaarel Adamberg, Harjumaa EE
Patent application number | Description | Published |
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20150140544 | BIOREACTOR SYSTEM AND METHOD FOR CLONING THE PHYSIOLOGICAL STATE OF MICROORGANISMS - Bioreactor system and method for cloning the physiological state of microorganisms comprises in preferred embodiment of a mother-reactor and one or more daughter-reactors with sensors, stirrers, fluid and gas flow channels, scales, pumps, controllers, computer, software, valves and accessory devices. The bioreactors are inter-connected with culture transfer hose. To achieve the method, the mother-reactor is filled with necessary volume, inoculated, stabilised in continuous cultivation, the microbial culture's volume is increased in variable volume cultivation while maintaining constant physiology, microbial culture is transferred from the mother-reactor into the daughter-reactors while maintaining constant physiology, experiment in the daughter reactor follows. After the experiment daughter-reactors are sterilized and rinsed. During the experiment culture volume in the mother-reactor is increased anew, after the experiment in the daughter-reactors is finished another culture transfer follows and next experiment is conducted. This sequence—variable volume cultivation, culture transfer, experiment—is repeated until necessary data has been acquired. | 05-21-2015 |
Kaarel Krjutskov, Tartu EE
Patent application number | Description | Published |
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20090048119 | Method to determine single nucleotide polymorphisms and mutations in nucleic acid sequence - A genotyping method and a prepared oligomicroarray as device is to determine single nucleotide polymorphism (SNP) and mutations are provided. The method uses two specific APEX-2 primers per each SNP or mutations to be determined. The same primers are used in amplification phase (primer extension and PCR with universal primer) and in the single base extension phase on an array. All SNP-containing sequences can be genotyped and amplified in one reaction tube and visualized on a microarray. | 02-19-2009 |
20130096212 | Method and a Kit to Predict Response to Antidepressant Treatment - The present invention relates to the method for predicting the pharmacoresponse of antidepressants in patients diagnosed with major depression and panic disorder. According to the invention, SNP (rs41271330) in the coding region of the BMP5 gene together with the markers in linkage disequilibrium with this SNP could be used as predictors of SSRI treatment efficacy. The knowledge obtained by using the method disclosed in present invention has potential to increase the efficacy of pharmacological treatment in patients with major depression and panic disorder. The invention also provides a kit for detecting individual who are likely to respond to antidepressant treatment. | 04-18-2013 |
Kaarel Truuvert, Toronto CA
Patent application number | Description | Published |
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20080270590 | DYNAMIC CONFIGURATION AND SELF-TUNING OF INTER-NODAL COMMUNICATION RESOURCES IN A DATABASE MANAGEMENT SYSTEM - A database management system in which a plurality of nodes form a database instance, each node including a communication manager for dynamically configuring inter-nodal communication resources. The communication manager receives communication resource allocation requests from clients or a self-tuning algorithm. A resource self-tuning mechanism allocates or de-allocates memory blocks used for communication resource elements dynamically in real time without cycling the instance. Memory blocks are de-allocated asynchronously by placing associated communication resource elements in quarantine until all communication resource elements associated with the memory block are quarantined. | 10-30-2008 |
20090024653 | DYNAMIC CONFIGURATION AND SELF-TUNING OF INTER-NODAL COMMUNICATION RESOURCES IN A DATABASE MANAGEMENT SYSTEM - A database management system in which a plurality of nodes form a database instance, each node including a communication manager for dynamically configuring inter-nodal communication resources. The communication manager receives communication resource allocation requests from clients or a self-tuning algorithm. A resource self-tuning mechanism allocates or de-allocates memory blocks used for communication resource elements dynamically in real time without cycling the instance. Memory blocks are de-allocated asynchronously by placing associated communication resource elements in quarantine until all communication resource elements associated with the memory block are quarantined. | 01-22-2009 |