Patent application number | Description | Published |
20090247596 | THIOPHENECARBOXAMIDE DERIVATIVES AS EP4 RECEPTOR LIGANDS - The invention is directed to thiophenecarboxamide derivatives of formulae I and II as EP4 receptor ligands, antagonists or agonists, useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic pain, osteoarthritis, rheumatoid arthritis, cancer and glaucoma. Pharmaceutical compositions and methods of use are also included. (Formulas I and II). | 10-01-2009 |
20090264479 | Papain Family Cysteine Protease Inhibitors for the Treatment of Parasitic Diseases - Several parasites responsible for mammalian diseases are dependent on cysteine protease for various life-cycle functions. Inhibition of these proteases can be useful in the treatment of these parasitic diseases, including toxoplasmosis, malaria, African trypanosomiasis, Chagas disease, leishmaniasis or schistosomiasis. | 10-22-2009 |
20100048551 | Tricyclic Compounds Useful as Inhibitors of Kinases - The present invention provides inhibitors of kinases, specifically IκB kinases, JAK1, JAK2, JAK3 and TYK2. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting said kinase activity by administering the compound to a patient in need of treatment for myeloproliferative disorders, cancer or NF-κB-mediated diseases. | 02-25-2010 |
20100305056 | CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASE - Several parasites responsible for mammalian diseases are dependent on cysteine protease for various life-cycle functions. Inhibition or decreasing function of these proteases can be useful in the treatment and/or prevention of these parasitic diseases including; toxoplasmosis, malaria, African trypanosomiasis, Chagas disease, leishmaniasis, schistosomiasis, amebiasis, giardiasis, clonorchiasis, opisthorchiasis, paragonimiasis, fasciolopsiasis, lymphatic filariasis, onchocerciasis, dracunculiasis, ascariasis, trichuriasis, strongyloidiasis, trichostrongyliasis, trichomoniasis or cestodiasis. Compounds of formula I of the invention are capable of treating and/or preventing the above-identified diseases: | 12-02-2010 |
20120035214 | RENIN INHIBITORS - The present invention relates to biaryl piperidine-based renin inhibitor compounds, and their use in treating cardiovascular events and renal insufficiency. | 02-09-2012 |
20130035312 | CATHEPSIN CYSTEINE PROTEASE INHIBIORS - This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis. | 02-07-2013 |
Patent application number | Description | Published |
20130244962 | CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES - Several parasites responsible for mammalian diseases are dependent on cysteine protease for various life-cycle functions. Inhibition or decreasing function of these proteases can be useful in the treatment and/or prevention of these parasitic diseases including; toxoplasmosis, malaria, African trypanosomiasis, Chagas disease, leishmaniasis, schistosomiasis, amebiasis, giardiasis, clonorchiasis, opisthorchiasis, paragonimiasis, fasciolopsiasis, lymphatic filariasis, onchocerciasis, dracunculiasis, ascariasis, trichuriasis, stronglyoidiasis, trichostrongyliasis, trichomoniasis or cestodiasis. | 09-19-2013 |
Patent application number | Description | Published |
20080271345 | BOOT ARTICULATION SUPPORT SYSTEM - The present invention relates to a support system for use in relation to an articulation region of a boot. Embodiments of the present invention relate to a boot with a dorsal metatarsal articulation region that allows for articulation in the sagittal plane such as a telemark ski boot. One embodiment of the present invention relates to a telemark ski boot, including a shell, an articulation region, and an articulation support system. The articulation support system includes at least one tensile rigid region extending transversely between the proximal and distal sides of the articulation region. The tensile rigid region impedes rotation of the rear portion of the shell about the toe portion in a frontal plane. This form of rotation is often referred to as torsional rotation. The articulation support system may include one or more of a cable, an integrated shell portion, a material mesh, and/or other tensile rigid components which maintain bending flexibility. A second embodiment of the present invention relates to a method for increasing the torsional support characteristic of a telemark ski boot while maintaining the desired flexibility. | 11-06-2008 |
20090113763 | MODULAR BOOT SOLE SYSTEM - One embodiment of the present invention relates to a ski boot system with a modular binding interface. The system includes a shell encasing a user's foot and lower leg. A first and second block are interchangeably coupled to the shell below the base to effectuate alternative binding interfaces. The first and second blocks include a binding interface surface and a sole surface. The positioning and shape of the blocks with respect to the shell results in the binding interface surface extending distally from the toe region of the shell and the sole surface being the lowest surface on the boot system. The binding interface surfaces for each block are positioned at different sagittal heights with respect to the shell to facilitate the interconnection with alternative binding coupling systems. The sole surfaces for each block are positioned at substantially identical sagittal heights with respect to the shell to maintain optimum and consistent performance characteristics among different bindings. | 05-07-2009 |
20090113764 | SELECTABLE BOOT ARTICULATION SYSTEM - One embodiment of the present invention relates to a ski boot system including an upper shell, lower shell, and an articulation system. The upper and lower shell function to enable a user to move their encased foot in various dimensions/orientations corresponding to anatomical supination, pronation, dorsiflexion, and plantarflexion. The articulation system selectively affects the articulation freedom between the upper and lower shells in locked and unlocked configurations. The articulation system includes a lower shell coupler and an upper shell coupler coupled to the lower and upper shells, respectively. The locked configuration of the articulation system includes engaging the upper and lower shell couplers to restrict freedom between the upper and lower shell. The lower shell coupler is coupled within a recess in the lower shell that substantially restricts movement to a single orientation corresponding to coronal rotation. | 05-07-2009 |
Patent application number | Description | Published |
20120003701 | Heterologous Expression of Termite Cellulases Yeast - The present invention provides for heterologous expression of termite and termite-associated symbiont cellulases. The cellulases can, for example, be codon-optimized and expressed in yeast host cells, such as the yeast | 01-05-2012 |
20120129229 | Yeast Expressing Cellulases for Simultaneous Saccharification and Fermentation Using Cellulose - Host cells, comprising | 05-24-2012 |
20120142046 | Yeast Cells Expressing An Exogenous Cellulosome And Methods of Using The Same - The present invention relates to the engineering and expression of heterologous cellulosomes in microorganisms in order to facilitate the conversion of biomass to useful products. In some embodiments, the invention relates to the expression of scaffoldin proteins which form the nucleus of a cellulosome. Cellulases or other biomass-degrading enzymes can be non-covalently linked to the scaffoldin protein by virtue of a dockerin domain-cohesin domain interaction. | 06-07-2012 |
20130323822 | Yeast Expressing Saccharolytic Enzymes for Consolidated Bioprocessing Using Starch and Cellulose - The present invention is directed to a yeast strain, or strains, secreting a full suite, or any subset of that full suite, of enzymes to hydrolyze corn starch, corn fiber, lignocellulose, (including enzymes that hydrolyze linkages in cellulose, hemicellulose, and between lignin and carbohydrates) and to utilize pentose sugars (xylose and arabinose). The invention is also directed to the set of proteins that are well expressed in yeast for each category of enzymatic activity. The resulting strain, or strains can be used to hydrolyze starch and cellulose simultaneously. The resulting strain, or strains can be also metabolically engineered to produce less glycerol and uptake acetate. The resulting strain, or strains can also be used to produce ethanol from granular starch without liquefaction. The resulting strain, or strains, can be further used to reduce the amount of external enzyme needed to hydrolyze a biomass feedstock during an Simultaneous Saccharification and Fermentation (SSF) process, or to increase the yield of ethanol during SSF at current saccharolytic enzyme loadings. In addition, multiple enzymes of the present invention can be co-expressed in cells of the invention to provide synergistic digestive action on biomass feedstock. In some aspects, host cells expressing different heterologous saccharolytic enzymes can also be co-cultured together and used to produce ethanol from biomass feedstock. | 12-05-2013 |
20140308724 | Yeast Expressing Saccharolytic Enzymes for Consolidated Bioprocessing Using Starch and Cellulose - The present invention is directed to a yeast strain, or strains, secreting a full suite, or any subset of that full suite, of enzymes to hydrolyze corn starch, corn fiber, lignocellulose, (including enzymes that hydrolyze linkages in cellulose, hemicellulose, and between lignin and carbohydrates) and to utilize pentose sugars (xylose and arabinose). The invention is also directed to the set of proteins that are well expressed in yeast for each category of enzymatic activity. The resulting strain, or strains can be used to hydrolyze starch and cellulose simultaneously. The resulting strain, or strains can be also metabolically engineered to produce less glycerol and uptake acetate. The resulting strain, or strains can also be used to produce ethanol from granular starch without liquefaction. The resulting strain, or strains, can be further used to reduce the amount of external enzyme needed to hydrolyze a biomass feedstock during an Simultaneous Saccharification and Fermentation (SSF) process, or to increase the yield of ethanol during SSF at current saccharolytic enzyme loadings. In addition, multiple enzymes of the present invention can be co-expressed in cells of the invention to provide synergistic digestive action on biomass feedstock. In some aspects, host cells expressing different heterologous saccharolytic enzymes can also be co-cultured together and used to produce ethanol from biomass feedstock. | 10-16-2014 |
20150024438 | Heterologous Expression of Termite Cellulases in Yeast - The present invention provides for heterologous expression of termite and termite-associated symbiont cellulases. The cellulases can, for example, be codon-optimized and expressed in yeast host cells, such as the yeast | 01-22-2015 |