Patent application number | Description | Published |
20080292712 | METHODS AND COMPOSITIONS FOR ENHANCED DELIVERY OF BIOACTIVE MOLECULES - Formulations for controlled, prolonged release of bioactive molecules such as therapeutic proteins, peptides and oligonucleotides have been developed. These formulations are based on solid microparticles or nanoparticles formed of the combination of biodegradable, synthetic polymers such as poly (lactic acid) (PLA), poly (glycolic acid) (PGA), and copolymers thereof. Bioactive molecules are coupled to hydrophilic polymers such as polyethylene glycol or polypropylene glycol and formulated to provide controlled release. The bioactive molecules are more stable, less immunogenic and have improved release rate profiles with lower burst levels and increased drug loading relative to the same bioactive molecules lacking coupled hydrophilic polymers. The controlled release formulations can be administered by injection, by inhalation, nasally, or orally. | 11-27-2008 |
20150216995 | Method for Preparation of Site-Specific Protein Conjugates - The invention is directed to a single-step method for rapidly and efficiently preparing protein-polymer conjugates, including an insulin-polymer conjugate. According to the method of the present invention, a protein and hydrophilic polymer are contacted in the presence of at least one organic solvent and at least one metal chelator, under conditions that promote the formation of a conjugate of the protein and polymer. Thus, the invention is directed to the site-specific modification of selected proteins, such as insulin, with poly(ethylene glycol) at residue PheB1. The invention also provides a pharmaceutical formulation for encapsulating the conjugate in a biodegradable polymer. | 08-06-2015 |
Patent application number | Description | Published |
20090042825 | Composition, method of preparation & application of concentrated formulations of condensed nucleic acids with a cationic lipopolymer - Compositions, methods, and applications that increase the efficiency of nucleic acid transfection are provided. In one aspect, a pharmaceutical composition may include at least about 0.5 mg/ml concentration of a nucleic acid condensed with a cationic lipopolymer suspended in an isotonic solution, where the cationic lipopolymer includes a cationic polymer backbone having cholesterol and polyethylene glycol covalently attached thereto, and wherein the molar ratio of cholesterol to cationic polymer backbone is within a range of from about 0.1 to about 10, and the molar ratio of polyethylene glycol to cationic polymer backbone is within a range of from about 0.1 to about 10. The composition further may include a filler excipient. | 02-12-2009 |
20090042829 | Nucleic Acid-Lipopolymer Compositions - Compositions, methods, and applications that increase the efficiency of nucleic acid transfection are provided. In one aspect, a pharmaceutical composition may include at least about 0.5 mg/ml concentration of a nucleic acid condensed with a cationic lipopolymer suspended in an isotonic solution, where the cationic lipopolymer includes a cationic polymer backbone having cholesterol and polyethylene glycol covalently attached thereto, and wherein the molar ratio of cholesterol to cationic polymer backbone is within a range of from about 0.1 to about 10, and the molar ratio of polyethylene glycol to cationic polymer backbone is within a range of from about 0.1 to about 10. The composition further may include a filler excipient. | 02-12-2009 |
20110218231 | Combination of Immuno Gene Therapy and Chemotherapy for Treatment of Cancer and Hyperproliferative Diseases - Pharmaceutical compositions comprising a nucleic acid, a gene delivery polymer, and at least one adjunctive chemotherapeutic drug for the treatment of mammalian cancer or hyperproliferative disorders and methods of using thereof for the treatment of mammalian cancer or hyperproliferative disorders by intratumoral, intraperitoneal or systemic injection. | 09-08-2011 |
20130065942 | Nucleic Acid-Lipopolymer Compositions - Compositions, methods, and applications that increase the efficiency of nucleic acid transfection are provided. In one aspect, a pharmaceutical composition may include at least about 0.5 mg/ml concentration of a nucleic acid condensed with a cationic lipopolymer suspended in an isotonic solution, where the cationic lipopolymer includes a cationic polymer backbone having cholesterol and polyethylene glycol covalently attached thereto, and wherein the molar ratio of cholesterol to cationic polymer backbone is within a range of from about 0.1 to about 10, and the molar ratio of polyethylene glycol to cationic polymer backbone is within a range of from about 0.1 to about 10. The composition further may include a filler excipient. | 03-14-2013 |
20140186375 | Combination of Immuno Gene Therapy and Chemotherapy for Treatment of Cancer and Hyperproliferative Diseases - Pharmaceutical compositions comprising a nucleic acid, a gene delivery polymer, and at least one adjunctive chemotherapeutic drug for the treatment of mammalian cancer or hyperproliferative disorders and methods of using thereof for the treatment of mammalian cancer or hyperproliferative disorders by intratumoral, intraperitoneal or systemic injection. | 07-03-2014 |
Patent application number | Description | Published |
20090129585 | Exclusive encryption system - An encryption system includes a plurality of encryption operations including individual encryption operations and group encryption operations available for application in the encryption of data. The plurality of encryption operations are selected from the group consisting of functional variance, functional alignment, mathematical offset, wide XOR function, short logical rotation, long logical rotation, functional order, and address encryption. The system includes at least one round of encryption composed of a first encryption operation and a second encryption operation. The first encryption operation is selected from the plurality of encryption operations acting upon input data to generate a first encrypted data set. The second encryption operation is selected from the plurality of encryption operations acting upon the first encrypted data set to generate a second encrypted data set. The first encryption operation and the second encryption operation are different. | 05-21-2009 |
20100213951 | METHOD AND SYSTEM FOR DETECTION OF TAMPERING RELATED TO REVERSE ENGINEERING - A sensor system for protecting products and technology from reverse engineering by detecting attempts to probe electronic circuitry includes a sensor electrically linked to electronic circuitry. The sensor detects interaction of probe devices with the electronic circuitry for the purpose of reverse engineering the electronic circuitry. The sensor includes an exciter and an impedance counter linked to the exciter. A count rate of the impedance counter is a function of the impedance of the electronic circuitry due to the fact that oscillation frequency generated by the exciter is also a function of the impedance of the electronic circuitry. The sensor also includes an impedance register storing the binary count value from the impedance counter, wherein after the impedance counter data is transferred into the impedance register, the data is referred to as impedance data. The sensor also includes a reference oscillator monitoring count rate of the impedance counter and a sensor evaluation system comparing the impedance value to threshold values to determine if a significant change has occurred. When changes have occurred this is indicative of abnormal behavior and may be indicative of tampering relating to the evaluation of the electronic circuit for the purpose of reverse engineering. | 08-26-2010 |
20100232600 | Exclusive encryption system - An encryption system includes a plurality of encryption operations including individual encryption operations and group encryption operations available for application in the encryption of data. The plurality of encryption operations are selected from the group consisting of functional variance, functional alignment, mathematical offset, wide XOR function, short logical rotation, long logical rotation, functional order, and address encryption. The system includes at least one round of encryption composed of a first encryption operation and a second encryption operation. The first encryption operation is selected from the plurality of encryption operations acting upon input data to generate a first encrypted data set. The second encryption operation is selected from the plurality of encryption operations acting upon the first encrypted data set to generate a second encrypted data set. The first encryption operation and the second encryption operation are different. | 09-16-2010 |
20110234241 | METHOD AND SYSTEM FOR PROTECTING PRODUCTS AND TECHNOLOGY FROM INTEGRATED CIRCUITS WHICH HAVE BEEN SUBJECT TO TAMPERING, STRESSING AND REPLACEMENT AS WELL AS DETECTING INTEGRATED CIRCUITS THAT HAVE BEEN SUBJECT TO TAMPERING - A system employs physical unclonable functions of an integrated circuit for detecting integrated circuits and protecting products and technology from integrated circuits which have been subject to tampering, stressing and replacement, and counterfeit components. The system includes a sensor detecting a characteristic impedance generated as a result of controlled access to a memory device of the integrated circuit. The characteristic impedance is applied in the creation of a discrimination matrix of values based on electrical interface signals for the integrated circuit. The sensor includes a ring oscillator and associated monitoring components. The ring oscillator is composed of the memory device of the integrated circuit and a sensory circuitry, wherein changes in a frequency generated by the ring oscillator is indicative of changes in circuitry. | 09-29-2011 |
20120212253 | METHOD AND SYSTEM FOR IDENTIFYING COUNTERFEIT PROGRAMMABLE LOGIC DEVICES - A method for combating counterfeiting and tampering of integrated circuits includes the steps providing a programmable logic device, the programmable logic device including an arithmetic circuit implemented into the substrate, and constructing an arithmetic feedback oscillator using the arithmetic circuit. The step of constructing the arithmetic feedback oscillator includes incorporating a feedback loop into the arithmetic circuit and feeding output bits back into an input of the arithmetic circuit. The method also includes the step of selecting input values producing repeating values in a lesser order bit of a product of the arithmetic circuit when first and second input are applied to the arithmetic circuit and monitoring the lesser order bit and determining a predicted pattern. | 08-23-2012 |
20130276059 | ELECTRONIC PHYSICAL UNCLONABLE FUNCTIONS - An electronic asymmetric unclonable function applied to an electronic system being evaluated includes an electronic system and an AUF array electronically associated with the electronic system. The AUF array includes a plurality of non-identical cells. Each of the non-identical cells includes a test element representing a characteristic of the electronic system being evaluated and a measurement device evaluating the test element. A comparison unit processes an output of the measurement device to provide a multi-bit output value representing a magnitude of differences. | 10-17-2013 |
20130276151 | ELECTRONIC PHYSICAL UNCLONABLE FUNCTIONS - An electronic asymmetric unclonable function applied to an electronic system being evaluated includes an electronic system and an AUF array electronically associated with the electronic system. The AUF array includes a plurality of non-identical cells. Each of the non-identical cells includes a test element representing a characteristic of the electronic system being evaluated and a measurement device evaluating the test element. A comparison unit processes an output of the measurement device to provide a multi-bit output value representing a magnitude of differences. | 10-17-2013 |