Liu, PA
Changbao Liu, Radnor, PA US
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20090130661 | Method for Detecting IL-16 Activity and Modulation of IL-16 Activity Based on Phosphorylated Stat-6 Proxy Levels - Methods for detecting IL-16 biological activity, detecting modulation of IL-16 biological activity, and diagnosing the presence of, or susceptibility to, an IL-16-related disorder in a subject involve measuring and comparing the levels of a phosphorylated STAT-6 proxy produced by eukaryotic cells expressing CD4 or CD9, peripheral blood mononuclear cells, HuT-78 cells, or THP-1 cells. | 05-21-2009 |
Changbao Liu, Malvern, PA US
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20110027294 | Anti-Respiratory Syncytial Virus Antibodies, Antigens and Uses Thereof - Anti-Respiratory Syncytial Virus (RSV) monoclonal antibodies, RSV F protein antigens and their uses are disclosed. | 02-03-2011 |
Changchun Liu, Philadelphia, PA US
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20100035349 | Biodetection Cassette with Automated Actuator - Provided are analysis cassettes that include removable sealing layers and deformable connector layers that place various channels, chambers, and reservoirs on the cassettes into fluid communication with one another. The cassettes are suitable for use in self-contained, immunoassay devices that may be operated in an automated fashion. Also disclosed are methods for analyzing samples by use of the disclosed cassettes. | 02-11-2010 |
20120245042 | DEBUBBLER FOR MICROFLUIDIC SYSTEMS - Provided are robust, passive, membrane-based debubblers that are readily incorporated into microfluidic devices for rapid degassing. Also provided are methods of degassing fluid disposed within fluidic systems. | 09-27-2012 |
Changsheng Liu, State College, PA US
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20090090630 | Automated parallel capillary electrophoresis system with hydrodynamic sample injection - An automated capillary zone electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from one side of a plate. The first array of capillary ends is spaced apart in substantially the same manner as the wells of a microtitre tray of standard size. This allows one to simultaneously perform capillary electrophoresis on samples present in each of the wells of the tray. The system includes a stacked, dual carrousel arrangement to eliminate cross-contamination resulting from reuse of the same buffer tray on consecutive executions from electrophoresis. The system also has a container connected to the detection end of the capillaries. The container is provided with valving which facilitate cleaning the capillaries, loading buffer into the capillaries, introducing samples to be electrophoresed into the capillaries, and performing capillary zone electrophoresis on the thus introduced samples. | 04-09-2009 |
20090301884 | Electrophoretic analysis system having in-situ calibration - An electrophoretic system having a plurality of separation lanes is provided with an automatic calibration feature in which each lane is separately calibrated. For each lane, the calibration coefficients map a spectrum of received channel intensities onto values reflective of the relative likelihood of each of a plurality of dyes being present. Individual peaks, reflective of the influence of a single dye, are isolated from among the various sets of detected light intensity spectra, and these can be used to both detect the number of dye components present, and also to establish exemplary vectors for the calibration coefficients which may then be clustered and further processed to arrive at a calibration matrix for the system. The system thus permits one to use different dye sets to tag DNA nucleotides in samples which migrate in separate lanes, and also allows for in-situ calibration with new, previously unused dye sets. | 12-10-2009 |
20100116659 | Multidimensional Separations Employing an Array of Electrophoresis Channels - The present invention relates to a method for separating components of a sample. The method includes obtaining a first separation of the sample components along a first dimension wherein the sample components are at least partially resolved, wherein the first separation can be performed in the absence of an electric field applied to the first dimension. An electric field is used to obtain a second separation of the sample components along a second dimension comprising a plurality of substantially isolated volumes. An intensity-time data record is obtained from each of the isolated volumes, the intensity-time data records containing peaks, each peak being indicative of a migration time. The migration time of a first peak is normalized with respect to a migration time of at least a second peak to correct for migration time differences between the isolated volumes. | 05-13-2010 |
20100147692 | Automated Parallel Capillary Electrophoresis System with Hydrodynamic Sample Injection - An automated capillary zone electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from one side of a plate. The first array of capillary ends is spaced apart in substantially the same manner as the wells of a microtitre tray of standard size. This allows one to simultaneously perform capillary electrophoresis on samples present in each of the wells of the tray. The system includes a stacked, dual carrousel arrangement to eliminate cross-contamination resulting from reuse of the same buffer tray on consecutive executions from electrophoresis. The system also has a container connected to the detection end of the capillaries. The container is provided with valving which facilitate cleaning the capillaries, loading buffer into the capillaries, introducing samples to be electrophoresced into the capillaries, and performing capillary zone electrophoresis on the thus introduced samples. | 06-17-2010 |
20110220508 | Automated Parallel Capillary Electrophoresis System with Hydrodynamic Sample Injection - An automated capillary zone electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from one side of a plate. The first array of capillary ends is spaced apart in substantially the same manner as the wells of a microtitre tray of standard size. This allows one to simultaneously perform capillary electrophoresis on samples present in each of the wells of the tray. The system includes a stacked, dual carrousel arrangement to eliminate cross-contamination resulting from reuse of the same buffer tray on consecutive executions from electrophoresis. The system also has a container connected to the detection end of the capillaries. The container is provided with valving which facilitate cleaning the capillaries, loading buffer into the capillaries, introducing samples to be electrophoresced into the capillaries, and performing capillary zone electrophoresis on the thus introduced samples. | 09-15-2011 |
20110232356 | Electrophoretic Analysis System Having In-Situ Calibration - An electrophoretic system having a plurality of separation lanes is provided with an automatic calibration feature in which each lane is separately calibrated. For each lane, the calibration coefficients map a spectrum of received channel intensities onto values reflective of the relative likelihood of each of a plurality of dyes being present. Individual peaks, reflective of the influence of a single dye, are isolated from among the various sets of detected light intensity spectra, and these can be used to both detect the number of dye components present, and also to establish exemplary vectors for the calibration coefficients which may then be clustered and further processed to arrive at a calibration matrix for the system. The system thus permits one to use different dye sets to tag DNA nucleotides in samples which migrate in separate lanes, and also allows for in-situ calibration with new, previously unused dye sets. | 09-29-2011 |
Changsheng Jonathan Liu, State College, PA US
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20090318310 | DNA Sequence Assembly Methods of Short Reads - Certain embodiments of the invention provide systems and methods for the automated assembly of DNA sequence data into contiguous DNA segments using a computer a system. DNA sequence data is entered into the system. The system indexes and groups a plurality of DNA fragment reads utilizing an anchor sequence and consolidates the fragments into larger sequences by merging the fragment reads within a group. | 12-24-2009 |
Chau-Ching Liu, Pittsburgh, PA US
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20090298198 | DIAGNOSING AND MONITORING INFLAMMATORY DISEASES BY MEASURING COMPLEMENT COMPONENTS ON WHITE BLOOD CELLS - The invention is related to methods of diagnosing inflammatory diseases or conditions by determining levels of components of the complement pathway on the surface of white blood cells. | 12-03-2009 |
20110275060 | DIAGNOSING AND MONITORING INFLAMMATORY DISEASES BY MEASURING COMPLEMENT COMPONENTS ON WHITE BLOOD CELLS - The invention is related to methods of diagnosing inflammatory diseases or conditions by determining levels of components of the complement pathway on the surface of white blood cells. | 11-10-2011 |
Chengyang Liu, Philidelphia, PA US
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20100272697 | PANCREATIC ISLET CELLS COMPOSITION AND METHODS - A composition comprising islet cells and an extracellular matrix component as well as methods of transplanting same are described. Retroperitoneal and subcutaneous islet cells transplants maintain their viability and increased insulin production for prolonged periods of time. | 10-28-2010 |
Dahui Liu, Wynnewood, PA US
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20100081665 | Anti-Malarial Compounds - The present invention provides tricyclic compounds, arylamide compounds, and other compounds, and compositions comprising the same, for treating malaria, and methods of treating malaria comprising administering such compounds to an animal. | 04-01-2010 |
20100105703 | Synthetic Mimetics Of Host Defense And Uses Thereof - The present invention provides arylamide compounds and methods of making and using them as antibiotics. | 04-29-2010 |
20100144761 | Antimicrobial Molecules For Treating Multi-Drug Resistant And Extensively Drug Resistant Strains Of Mycobacterium - The present invention provides methods of inhibiting the growth of | 06-10-2010 |
20100298344 | Polycationic Compounds And Uses Thereof - Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a polycationic compound. The present invention relates to methods of use and compositions for inhibiting angiogenesis-mediated disorders in mammals including animals and humans. Additionally, this invention relates to the combined use of polycations with other anti-angiogenesis agents for the treatment of different angiogenesis-mediated disorders. Additionally, those polycationic compounds can be used with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer patients to prevent and treat tumor growth and metastasis. | 11-25-2010 |
20110124664 | Polycationic Compounds And Uses Thereof - Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a polycationic compound. The present invention relates to methods of use and compositions for inhibiting angiogenesis-mediated disorders in mammals including animals and humans. Additionally, this invention relates to the combined use of polycations with other anti-angiogenesis agents for the treatment of different angiogenesis-mediated disorders. Additionally, those polycationic compounds can be used with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer patients to prevent and treat tumor growth and metastasis. | 05-26-2011 |
20120202887 | Facially Amphiphilic Polyaryl and Polyarylalkynyl Polymers and Oligomers and Uses Thereof - The present invention discloses methods of use of facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, including, but not limited to, pharmaceutical uses of the polymers and oligomers as antimicrobial agents and as antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, compositions of the novel polymers and oligomers, including pharmaceutical compositions, and methods of designing and synthesizing the facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers. | 08-09-2012 |
20120322878 | Polycationic Compounds And Uses Thereof - Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a polycationic compound. The present invention relates to methods of use and compositions for inhibiting angiogenesis-mediated disorders in mammals including animals and humans. Additionally, this invention relates to the combined use of polycations with other anti-angiogenesis agents for the treatment of different angiogenesis-mediated disorders. Additionally, those polycationic compounds can be used with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer patients to prevent and treat tumor growth and metastasis. | 12-20-2012 |
20130023561 | Facially Amphiphilic Polymers and Oligomers and Uses Thereof - The present invention discloses methods of use of facially amphiphilic polymers and oligomers, including pharmaceutical uses of the polymers and oligomers as antimicrobial agents and antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polymers and oligomers and their compositions, including pharmaceutical compositions. The present invention further discloses the design and synthesis of facially amphiphilic polymers and oligomers. | 01-24-2013 |
20130090345 | Synthetic Mimetics Of Host Defense And Uses Thereof - The present invention provides arylamide compounds and methods of making and using them as antibiotics. | 04-11-2013 |
20130137706 | Antimicrobial Molecules For Treating Multi-Drug Resistant and Extensively Drug Resistant Strains Of Mycobacterium - The present invention provides methods of inhibiting the growth of | 05-30-2013 |
20140051762 | POLYCATIONIC COMPOUNDS AND USES THEREOF - Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a polycationic compound. The present invention relates to methods of use and compositions for inhibiting angiogenesis-mediated disorders in mammals including animals and humans. Additionally, this invention relates to the combined use of polycations with other anti-angiogenesis agents for the treatment of different angiogenesis-mediated disorders. Additionally, those polycationic compounds can be used with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer patients to prevent and treat tumor growth and metastasis. | 02-20-2014 |
20140308317 | Polymeric Compounds And Methods Of Making And Using The Same - The present disclosure provides compounds, or pharmaceutically acceptable salts thereof, for inhibiting the growth of a microbe; treating a mammal having a microbial infection, malaria, mucositis, an ophthalmic infection, an otic infection, a cancer, or a | 10-16-2014 |
20150072997 | ANTI-MALARIAL COMPOUNDS - The present invention provides tricyclic compounds, arylamide compounds, and other compounds, and compositions comprising the same, for treating malaria, and methods of treating malaria comprising administering such compounds to an animal. | 03-12-2015 |
Dahui Liu, Radnor, PA US
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20110098498 | Processes For Preparing A Polymeric Compound - The present invention provides methods for preparing a polymeric compound of Formula I: | 04-28-2011 |
20110178104 | Anti-Heparin Compounds - The present invention provides compounds and methods for antagonizing the anticoagulant effect of an anticoagulant agent that is selected from UFH, LMWH, and a heparin/LMWH derivative in a patient comprising administering to the patient a compound of the invention or a salt thereof, or a composition comprising the same. | 07-21-2011 |
20130274502 | Processes For Preparing A Polymeric Compound - The present invention provides methods for preparing a polymeric compound of Formula I: | 10-17-2013 |
20150031738 | CYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME - The present invention provides compounds, or pharmaceutically acceptable salts thereof, for inhibiting the growth of a microbe; treating a mammal having a microbial infection, mucositis, an ophthalmic infection, an otic infection, a cancer, or a | 01-29-2015 |
Dan Liu, Washington, PA US
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20100153583 | SYSTEM AND METHOD FOR DELIVERING CUSTOMIZED CONTENT TO MOBILE DEVICES - The illustrative embodiment of the present invention provides a platform that enables a content developer to distribute uniform content to multiple types of requesting mobile devices. By authoring content in a generic markup language and using the technologies included in the Mobile Content Framework (MCF), the content developer is able to provide content to multiple types devices without providing different versions of the content. The content may be authored originally in the generic markup language or translated from other languages into the generic markup language by the MCF. The MCF exploits the capabilities and accommodates the limitations of different types of wireless devices by converting generic markup language content to device-specific content. The MCF interacts with device registries holding records of the device attributes in order to provide the device-specific content. The MCF handles these issues for current mobile devices while also being extensible for future mobile devices. | 06-17-2010 |
George Dacai Liu, Collegeville, PA US
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20100304999 | SYSTEM AND METHOD FOR ANTIGEN STRUCTURE-INDEPENDENT DETECTION OF ANTIGENS CAPTURED ON ANTIBODY ARRAYS - The present invention provides a system and method for detecting antigens captured on an antibody array. The method comprises the following steps of providing the antibody array having at least two antibodies, contacting the antibody array with a sample containing at least one antigen that may be captured by the antibodies disposed on the antibody array, and detecting the at least one antigen captured by the antibody array with a detecting agent that specifically binds to the antigen-bound antibodies on the antibody array, thereby the at least one antigen captured by the antibody array can be detected independent of the structures of the antigens. In a preferred embodiment, C1q is used as the detecting agent to detect antigen-bound antibodies. | 12-02-2010 |
20120107354 | VIRAL VACCINE AND PROCESS FOR PREPARING THE SAME - The present invention provides a vaccine against a viral infection. The exemplary vaccine comprises a viral antigen of a vaccine strain of a virus; wherein the viral antigen is derived from a virus preparation of the vaccine strain of the virus; wherein the virus preparation of the vaccine strain of the virus contains a subpopulation of infectious viral particles, and the subpopulation of infectious viral particles is represented as a proportion over the total viral particles or total viral antigens of the virus preparation; and wherein the proportion of the subpopulation of infectious viral particles over the total viral particles or total viral antigens of the virus preparation is over a predefined threshold; so that the vaccine provides at least partial inter-subtypic or intra-subtypic cross immune response against different strains of the virus than the vaccine strain. | 05-03-2012 |
20120107910 | RECOMBINANT ENVELOPE PROTEIN OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) AND VACCINE CONTAINING THE SAME - The present invention provides a recombinant HIV Env antigenic protein, a virus-like particle and a recombinant HIV virus. The present invention further provides a vaccine comprising the recombinant HIV Env antigenic protein, the virus-like particle or recombinant HIV virus. | 05-03-2012 |
20120107911 | RECOMBINANT HEMAGGLUTININ PROTEIN OF INFLUENZA VIRUS AND VACCINE CONTAINING THE SAME - The present invention provides a recombinant hemagglutinin antigenic protein, a virus-like particle and a recombinant influenza virus. The present invention further provides a vaccine comprising the recombinant hemagglutinin antigenic protein, the virus-like particle or recombinant influenza virus. | 05-03-2012 |
20130101612 | VACCINE FOR ENVELOPED VIRUSES - The present invention provides a recombinant viral surface antigenic protein with enhanced stability. The present invention also provides a vaccine composition against enveloped viruses. | 04-25-2013 |
Guangyu Liu, Bethlehem, PA US
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20110133157 | SURFACE PLASMON DISPERSION ENGINEERING VIA DOUBLE-METALLIC AU/AG LAYERS FOR NITRIDE LIGHT-EMITTING DIODES - A double-metallic deposition process is used whereby adjacent layers of different metals are deposited on a substrate. The surface plasmon frequency of a base layer of a first metal is tuned by the surface plasmon frequency of a second layer of a second metal formed thereon. The amount of tuning is dependent upon the thickness of the metallic layers, and thus tuning can be achieved by varying the thicknesses of one or both of the metallic layers. In a preferred embodiment directed to enhanced LED technology in the green spectrum regime, a double-metallic Au/Ag layer comprising a base layer of gold (Au) followed by a second layer of silver (Ag) formed thereon is deposited on top of InGaN/GaN quantum wells (QWs) on a sapphire/GaN substrate. | 06-09-2011 |
20110147702 | NITRIDE BASED QUANTUM WELL LIGHT-EMITTING DEVICES HAVING IMPROVED CURRENT INJECTION EFFICIENCY - A III-nitride based device provides improved current injection efficiency by reducing thermionic carrier escape at high current density. The device includes a quantum well active layer and a pair of multi-layer barrier layers arranged symmetrically about the active layer. Each multi-layer barrier layer includes an inner layer abutting the active layer; and an outer layer abutting the inner layer. The inner barrier layer has a bandgap greater than that of the outer barrier layer. Both the inner and the outer barrier layer have bandgaps greater than that of the active layer. InGaN may be employed in the active layer, AlInN, AlInGaN or AlGaN may be employed in the inner barrier layer, and GaN may be employed in the outer barrier layer. Preferably, the inner layer is thin relative to the other layers. In one embodiment the inner barrier and active layers are 15 Å and 24 Å thick, respectively. | 06-23-2011 |
20110204328 | NITRIDE BASED DEVICES INCLUDING A SYMMETRICAL QUANTUM WELL ACTIVE LAYER HAVING A CENTRAL LOW BANDGAP DELTA-LAYER - A symmetrical quantum well active layer provides enhanced internal quantum efficiency. The quantum well active layer includes an inner (central) layer and a pair of outer layers sandwiching the inner layer. The inner and outer layers have different thicknesses and bandgap characteristics. The outer layers are relatively thick and include a relatively low bandgap material, such as InGaN. The inner layer has a relatively lower bandgap material and is sufficiently thin to act as a quantum well delta layer, e.g., comprising approximately 6 Å or less of InN. Such a quantum well structure advantageously extends the emission wavelength into the yellow/red spectral regime, and enhances spontaneous emission. The multi-layer quantum well active layer is sandwiched by barrier layers of high bandgap materials, such as GaN. | 08-25-2011 |
20110240082 | THERMOELECTRIC MATERIALS BASED ON SINGLE CRYSTAL AlInN-GaN GROWN BY METALORGANIC VAPOR PHASE EPITAXY - The invention is a thermoelectric device fabricated by growing a single crystal AlInN semiconductor material on a substrate, and a method of fabricating same. In a preferred embodiment, the semiconductor material is AlInN grown on and lattice-matched to a GaN template on a sapphire substrate, and the growth is performed using metalorganic vapor phase epitaxy (MOVPE). | 10-06-2011 |
20120217472 | BROADBAND LIGHT EMITTING DIODES AND METHOD FOR PRODUCING SAME - A III-Nitride semiconductor LED provides broadband light emission, across all or most of the visible light wavelength spectrum, and a method for producing same. The LED includes a polarization field management template that has a three-dimensional patterned surface. The surface may be patterned with an array of hemispherical cavities, which may be formed by growing the template around a temporary template layer of spherical or other crystals. The method involves growing a quantum well layer on the patterned surface. The topographical variations in the patterned surface of the template cause corresponding topographical variations in the quantum well layer. These variations in spatial orientation of portions of the quantum well layer cause the polarization field of the quantum well layer to vary across the surface of the LED, which leads to energy transition shifting that provides “white” light emission across a broad wavelength spectrum. | 08-30-2012 |
Guihua Liu, Radnor, PA US
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20090270480 | Markers and Methods for Assessing and Treating Psoriasis and Related Disorders - A method for prognostic or diagnostic assessment of a skin-related disorder, such as psoriasis, in a subject correlates the presence, absence, and/or magnitude of a gene in a sample with a reference standard to determine the presence and/or severity of the disorder, and/or the response to treatment for the disorder. The method enables identification of the effectiveness of candidate therapies. | 10-29-2009 |
Guopeng Liu, Plymouth Meeting, PA US
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20100318230 | Kitchens exhaust hood and make-up air handling unit optimal speed control system - Disclosed is a kitchen exhaust hood and makeup unit control system comprising a control device for controlling the variable speed drive (VSD) for the associated fan, and measurement devices comprising Volatile Organic Compound (VOC) gas transmitter devices and temperature transmitters devices. The exhaust fan VSD speed is controlled to maintain the kitchen hood area at certain comfort level (indoor air quality and thermal comfort) by monitoring the VOC concentration and exhaust duct temperature. The air quality sensors measure the concentration of multiple gases and odorous substances in the air with constant output. These substances, for example, may be cooking smoke, kitchen vapors, human odors and unpleasant smells. The exhaust fan speed is controlled using the proportional-integral-derivative (PID) control loop. The kitchen exhaust and make-up unit supply airflow rate may be measured by an airflow measurement means such as Fan Airflow Station. The kitchen make-up unit fan speed is controlled to maintain the constant airflow difference between the exhaust air and make-up air to maintain the slightly negative pressure in the kitchen area. | 12-16-2010 |
Hang Liu, Bucks, PA US
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20090319846 | ADAPTIVE ERROR CORRECTION METHOD FOR DATA TRANSMISSION AND DEVICES THEREOF - An adaptive error correction method for data transmission and the devices thereof are disclosed. By comparing the announced recovery data and data requested for error correction, no redundant join messages will be sent if the recovery data have been announced before. This will greatly reduce the number messages and save the band width of transmission. | 12-24-2009 |
Hongqi Liu, Wynnewood, PA US
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20100035829 | METHOD OF TREATING INTRAUTERINE INFLAMMATION - A method of treating intrauterine inflammation in a subject associated with intrauterine bacterial infection includes administering to the subject a therapeutically effective amount of a toll-like receptor 4 antagonist. The therapeutically effective amount administered to the subject is an amount effective in reducing intrauterine inflammation in the subject. | 02-11-2010 |
Hongzhou Liu, Pittsburgh, PA US
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20090144671 | DESIGNING INTEGRATED CIRCUITS FOR YIELD - Method and system for designing integrated circuits for yield are described. Integrated circuits are designed for yield by finding worst yield corners based on design, statistical, and environmental variables and optimizing the design in light of the worst yield corners found. | 06-04-2009 |
Hongzhou Liu, Sewickley, PA US
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20110153271 | METHODS AND SYSTEMS FOR HIGH SIGMA YIELD ESTIMATION - For an integrated circuit associated with a plurality of parameters whose values are described by a first probability distribution function, a method for estimating a failure probability includes selecting a first plurality of samples, performing a first test to determine an outcome for each of the first plurality of samples and identifying failed samples, and clustering the failed samples using a computer-implemented cluster forming method that, in some cases, returns multiple clusters. The method also includes forming a probability distribution function for each of the clusters, forming a composite probability distribution function that includes a weighted combination of the first probability distribution function and the probability distribution function for each of the clusters. The method further includes selecting a second plurality of samples using the composite probability distribution function and performing a second test to determine an outcome for each of the second plurality of samples. A failure probability can then be computed. | 06-23-2011 |
20110153272 | METHODS AND SYSTEMS FOR HIGH SIGMA YIELD ESTIMATION USING REDUCED DIMENSIONALITY - For an integrated circuit associated with a first plurality of parameters whose values are described by a first probability distribution function, a method for estimating a failure probability includes selecting a first plurality of samples, performing a first test to determine an outcome for each of the first plurality of samples and identifying failed samples. A second plurality of parameters is selected that has fewer parameters than the first plurality of parameters. The failed samples are clustered in the space of the second plurality of parameters using a computer-implemented cluster forming method that, in some cases, returns multiple clusters. The method also includes forming a probability distribution function for each of the clusters, forming a composite probability distribution function that includes a weighted combination of the first probability distribution function and the probability distribution function for each of the clusters. The method further includes selecting a second plurality of samples using the composite probability distribution function and performing a second test to determine an outcome for each of the second plurality of samples. A failure probability can then be computed. | 06-23-2011 |
Hsin-Yi Liu, Pittsburgh, PA US
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20100276975 | ANGLE ADJUSTABLE BACKREST MOUNTING - Angle adjustable backrest made of a lightweight, durable, adjustable, backrest for ultralight manual wheelchairs. Light-weight material can include composites for a rigid backrest for promotion of healthier and functional interface. Angle adjustment can be any desired range such as a range from −5 degree to 55 degrees (i.e. 85 degrees to 145 degree with respect to horizontal with the seat). No tools are necessary for any of the angle adjustments. The backrest has a horizontal adjustment (fore-aft) that can be any desired range such as 1 inch. The height selection depends on the length of the wheelchair frame tubes. The present invention improves the ease and simplicity of adjusting the backrest by or for the user, as well as enhances the aesthetic appearance and adds features necessary for achieving commercial readiness. The present invention can be retro fit onto a wide range for ultralight wheelchairs. | 11-04-2010 |
James Zhou Liu, Downingtown, PA US
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20100206244 | Animal Potty Chair - The present invention discloses an animal potty chair, particularly for a dog or cat, to be used indoor and/or outdoor to aid civilization of domestic animals and to improve quality of life for millions of families with animals. The animal potty chair comprising: (1) a defined space to guide an animal to release waste to a designated area; (2) a supporting mean covered with a mesh for an animal to stand and to release waste (3) a sealer-adaptor of the toilet; (4) a receptacle mean for animal waste; (5) a sensor to monitor an animal to come to a designated place; (6) a signal to indicate that an animal is/was at a designated place. The current invention has caused the revolutionary transformation of a pet from an accident-causing animal to a civilized non-human member of the family. There will be no more wet urine paw tracks left anywhere in the owner's house. Solid wastes stay on the top of the mesh, semi-liquid or loose feces fall into the toilet. The owner only needs to do minimal housekeeping, much easier than taking care of a human baby. The smell of the animal waste is reduced dramatically after the animal gets acquainted with using the current invention of an animal toilet. | 08-19-2010 |
20110146671 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF DELIVERING THE SAME - The present invention provides a pharmaceutical composition comprising a chemical compound or a herb extract or the combination having at least one of the activities of antiviral, antibacterial, antifungal, anti-inflammatory, anti-allergy, anti-cancer, promoting membrane healing or immunomodulating, for the treatment and prevention of a disease of a mammal. The present invention also provides a system for delivering the composition to the hard-to-reach sinuses of a mammal to reduce the load of the pathogen, to reduce the amount of inflammatory mediators, to heal pathological changes, and collectively to treat a disease of a mammal, such as allergic fungal rhinosinusitis. The invented method of treating a human disease reduces infectious and inflammatory agents without causing antibiotic resistance or adverse event. The present invention additionally provides a kit for collecting the nasal wash specimen to analyze how much drug is administered into sinonasal cavities or to determine the load of microbes in rhino-sinuses. | 06-23-2011 |
Jiantao T. Liu, Murrysville, PA US
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20110056597 | METHODS OF AGING ALUMINUM ALLOYS TO ACHIEVE IMPROVED BALLISTICS PERFORMANCE - Aluminum alloy products having improved ballistics performance are disclosed. The aluminum alloy products may be underaged. In one embodiment, the underaged aluminum alloy products realize an FSP resistance that it is better than that of a peak strength aged version of the aluminum alloy product. In one embodiment, ballistics performance criteria is selected and the aluminum alloy product is underaged an amount sufficient to achieve a ballistics performance that is at least as good as the ballistics performance criteria. | 03-10-2011 |
Jianto Liu, Murrysville, PA US
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20100127125 | METAL SHEETS AND PLATES HAVING FRICTION-REDUCING TEXTURED SURFACES AND METHODS OF MANUFACTURING SAME - Metal sheets and plates having friction-reducing textured surfaces and methods of manufacturing these metal sheets and plates are disclosed herein. In an embodiment, there is provided a transportation vessel that includes at least one metal product having at least one surface that is substantially grooved, wherein the substantially grooved surface forms a riblet topography, the riblet topography including a multiplicity of adjacent permanently rolled longitudinal riblets running along at least a part of the surface, and wherein the riblet topography is coated with at least one coating sufficiently designed and applied to preserve the riblet topography. In an embodiment, the multiplicity of adjacent permanently rolled longitudinal riblets results in a friction-reducing textured surface. In an embodiment, metal product is used in fabricating at least a portion of an aircraft. In an embodiment, metal product is used in fabricating at least a portion of a rotor blade. | 05-27-2010 |
20120227453 | METAL SHEETS AND PLATES HAVING FRICTION-REDUCING TEXTURED SURFACES AND METHODS OF MANUFACTURING SAME - Metal sheets and plates having friction-reducing textured surfaces and methods of manufacturing these metal sheets and plates are disclosed herein. In an embodiment, there is provided a transportation vessel that includes at least one metal product having at least one surface that is substantially grooved, wherein the substantially grooved surface forms a riblet topography, the riblet topography including a multiplicity of adjacent permanently rolled longitudinal riblets running along at least a part of the surface, and wherein the riblet topography is coated with at least one coating sufficiently designed and applied to preserve the riblet topography. In an embodiment, the multiplicity of adjacent permanently rolled longitudinal riblets results in a friction-reducing textured surface. In an embodiment, metal product is used in fabricating at least a portion of an aircraft. In an embodiment, metal product is used in fabricating at least a portion of a rotor blade. | 09-13-2012 |
Jianxin Liu, North Huntingdon, PA US
Patent application number | Description | Published |
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20080277837 | Gas Permeable Molds - Gas permeable molds and mold segments having open porosity ( | 11-13-2008 |
Jinfang Liu, Lancaster, PA US
Patent application number | Description | Published |
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20080221684 | Devices, systems, and methods to fixate tissue within the regions of body, such as the pharyngeal conduit - Devices, systems and methods develop static and/or kinetic and/or pressure forces to fixate or brace tissue in targeted pharyngeal structures and individual anatomic components within the pharyngeal conduit. | 09-11-2008 |
20110057756 | Rare Earth Composite Magnets with Increased Resistivity - Dielectric rare earth fluorides are blended with rare earth magnet powders to produce high-resistivity fluoride composite rare earth magnets. | 03-10-2011 |
20110200839 | Rare Earth Laminated, Composite Magnets With Increased Electrical Resistivity - Laminated, composite, permanent magnets comprising layers of permanent magnets separated by layers of dielectric or high electrical resistivity substances, wherein the laminated magnets indicate increased electrical resistivity. | 08-18-2011 |
20110275879 | MAGNETIC FORCE DEVICES, SYSTEMS, AND METHODS FOR RESISTING TISSUE COLLAPSE WITHIN THE PHARYNGEAL CONDUIT - Devices, systems and methods employ magnetic force to resist tissue collapse in targeted pharyngeal structures and individual anatomic components within the pharyngeal conduit during sleep. | 11-10-2011 |
20120019341 | COMPOSITE PERMANENT MAGNETS MADE FROM NANOFLAKES AND POWDERS - Composite RE-TM permanent magnets fabricated by using powders and nanoflakes produced by surfactant-assisted, wet, high energy, ball milling, with or without prior dry, high energy, ball milling; where RE represents rare earth elements and TM represents transition metals and where the powders include Fe nanoparticles, Fe—Co nanoparticles, B | 01-26-2012 |
20120019342 | Magnets made from nanoflake precursors - RE-TM based permanent magnets (single phase, hybrid, laminated or polymer bonded magnets) fabricated by using nanoflakes produced by surfactant assisted, wet, high energy ball-milling, with or without prior dry high energy ball-milling, where RE represents rare earth elements and TM represents transition metals. | 01-26-2012 |
20120021219 | MAGNETIC NANOFLAKES - Magnetic nanoflakes fabricated by surfactant assisted, wet, high energy ball milling of bulk precursors, with or without preceding dry, high energy ball milling, wherein certain nanoflakes indicate hard magnetic properties, crystallographic texture and magnetic anisotropy. | 01-26-2012 |
20130038159 | METHODS FOR SEQUENTIALLY LAMINATING RARE EARTH PERMANENT MAGNETS WITH SUFLIDE-BASED DIELECTRIC LAYER - Methods of manufacturing laminated, rare earth, permanent magnets with dielectric layers having increased electrical resistivity and improved mechanical strength suitable for use in high performance, rotating machines comprising sequentially laminating permanent magnet layers with transition and/or diffusion reaction layers; wherein the transition and/or diffusion reaction layers surround sulfide-based dielectric layers, thereby avoiding direct contact between the dielectric layers with permanent magnet layers. | 02-14-2013 |
20130038160 | SEQUENTIALLY LAMINATED, RARE EARTH, PERMANENT MAGNETS WITH SULFIDE-BASED DIELECTRIC LAYERS AND REINFORCED BY DIFFUSION REACTION LAYERS - Laminated, mechanically strong, rare earth, permanent magnets with dielectric layers having increased electrical resistivity and improved mechanical strength suitable for use in high performance, rotating machines comprising sequential laminates of permanent magnet layers and transition and/or diffusion reaction layers; wherein the transition and/or diffusion reaction layers surround sulfide-based dielectric layers, thereby avoiding direct contact between the dielectric layers with permanent magnet layers. | 02-14-2013 |
20130038164 | SEQUENTIALLY LAMINATED, RARE EARTH, PERMANENT MAGNETS WITH DIELECTRIC LAYERS REINFORCED BY TRANSITION AND/OR DIFFUSION REACTION LAYERS - Laminated, rare earth, permanent magnets with one or more dielectric layers, suitable for use in high performance, rotating machines comprising: sequential laminates of permanent magnet layers and dielectric layers separated by transition and/or diffusion reaction layers, where said sequentially laminated magnets indicate increased electrical resistivity with improved mechanical strength. | 02-14-2013 |
20150073565 | DEVICES, SYSTEMS, AND METHODS TO FIXATE TISSUE WITHIN THE REGIONS OF BODY, SUCH AS THE PHARYNGEAL CONDUIT - Devices, systems and methods develop static and/or kinetic and/or pressure forces to fixate or brace tissue in targeted pharyngeal structures and individual anatomic components within the pharyngeal conduit. | 03-12-2015 |
John Liu, Murrysville, PA US
Patent application number | Description | Published |
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20090011272 | METAL BODIES CONTAINING MICROCAVITIES AND APPARATUS AND METHODS RELATING THERETO - Monolithic metal bodies (e.g., hard aluminum alloys) comprising a continuous microcavity contained within the body are disclosed. The ratio of the cross-sectional area of the metal body to the cross-sectional area of the microcavity may be not greater than 10. The produced metal bodies may be used in structural applications (e.g., aerospace vehicles) to monitor or test the integrity of the metal body. | 01-08-2009 |
20100127125 | METAL SHEETS AND PLATES HAVING FRICTION-REDUCING TEXTURED SURFACES AND METHODS OF MANUFACTURING SAME - Metal sheets and plates having friction-reducing textured surfaces and methods of manufacturing these metal sheets and plates are disclosed herein. In an embodiment, there is provided a transportation vessel that includes at least one metal product having at least one surface that is substantially grooved, wherein the substantially grooved surface forms a riblet topography, the riblet topography including a multiplicity of adjacent permanently rolled longitudinal riblets running along at least a part of the surface, and wherein the riblet topography is coated with at least one coating sufficiently designed and applied to preserve the riblet topography. In an embodiment, the multiplicity of adjacent permanently rolled longitudinal riblets results in a friction-reducing textured surface. In an embodiment, metal product is used in fabricating at least a portion of an aircraft. In an embodiment, metal product is used in fabricating at least a portion of a rotor blade. | 05-27-2010 |
20110268603 | ALUMINUM ALLOY PRODUCTS HAVING IMPROVED PROPERTY COMBINATIONS AND METHOD FOR ARTIFICIALLY AGING SAME - Aluminum alloy products, such as plate, forgings and extrusions, suitable for use in making aerospace structural components like integral wing spars, ribs and webs, comprises about: 6 to 10 wt. % Zn; 1.2 to 1.9 wt. % Mg; 1.2 to 2.2 wt. % Cu, with Mg≦(Cu+0.3); and 0.05 to 0.4 wt. % Zr, the balance Al, incidental elements and impurities. Preferably, the alloy contains about 6.9 to 8.5 wt. % Zn; 1.2 to 1.7 wt. % Mg; 1.3 to 2 wt. % Cu. This alloy provides improved combinations of strength and fracture toughness in thick gauges. When artificially aged per the 3-stage method of preferred embodiments, this alloy also achieves superior SCC performance, including under seacoast conditions. | 11-03-2011 |
20120227453 | METAL SHEETS AND PLATES HAVING FRICTION-REDUCING TEXTURED SURFACES AND METHODS OF MANUFACTURING SAME - Metal sheets and plates having friction-reducing textured surfaces and methods of manufacturing these metal sheets and plates are disclosed herein. In an embodiment, there is provided a transportation vessel that includes at least one metal product having at least one surface that is substantially grooved, wherein the substantially grooved surface forms a riblet topography, the riblet topography including a multiplicity of adjacent permanently rolled longitudinal riblets running along at least a part of the surface, and wherein the riblet topography is coated with at least one coating sufficiently designed and applied to preserve the riblet topography. In an embodiment, the multiplicity of adjacent permanently rolled longitudinal riblets results in a friction-reducing textured surface. In an embodiment, metal product is used in fabricating at least a portion of an aircraft. In an embodiment, metal product is used in fabricating at least a portion of a rotor blade. | 09-13-2012 |
20130000123 | METAL BODIES CONTAINING MICROCAVITIES AND APPARATUS AND METHODS RELATING THERETO - Monolithic metal bodies (e.g., hard aluminum alloys) comprising a continuous microcavity contained within the body are disclosed. The ratio of the cross-sectional area of the metal body to the cross-sectional area of the microcavity may be not greater than 10. The produced metal bodies may be used in structural applications (e.g., aerospace vehicles) to monitor or test the integrity of the metal body. | 01-03-2013 |
20130312877 | ALUMINUM ALLOY PRODUCTS HAVING IMPROVED PROPERTY COMBINATIONS AND METHOD FOR ARTIFICIALLY AGING SAME - Aluminum alloy products, such as plate, forgings and extrusions, suitable for use in making aerospace structural components like integral wing spars, ribs and webs, comprises about: 6 to 10 wt. % Zn; 1.2 to 1.9 wt. % Mg; 1.2 to 2.2 wt. % Cu, with Mg≦(Cu+0.3); and 0.05 to 0.4 wt. % Zr, the balance Al, incidental elements and impurities. Preferably, the alloy contains about 6.9 to 8.5 wt. % Zn; 1.2 to 1.7 wt. % Mg; 1.3 to 2 wt. % Cu. This alloy provides improved combinations of strength and fracture toughness in thick gauges. When artificially aged per the 3-stage method of preferred embodiments, this alloy also achieves superior SCC performance, including under seacoast conditions. | 11-28-2013 |
20140248453 | METAL SHEETS AND PLATES HAVING FRICTION-REDUCING TEXTURED SURFACES AND METHODS OF MANUFACTURING SAME - Metal sheets and plates having friction-reducing textured surfaces and methods of manufacturing these metal sheets and plates are disclosed herein. In an embodiment, there is provided a transportation vessel that includes at least one metal product having at least one surface that is substantially grooved, wherein the substantially grooved surface forms a riblet topography, the riblet topography including a multiplicity of adjacent permanently rolled longitudinal riblets running along at least a part of the surface, and wherein the riblet topography is coated with at least one coating sufficiently designed and applied to preserve the riblet topography. In an embodiment, the multiplicity of adjacent permanently rolled longitudinal riblets results in a friction-reducing textured surface. In an embodiment, metal product is used in fabricating at least a portion of an aircraft. In an embodiment, metal product is used in fabricating at least a portion of a rotor blade. | 09-04-2014 |
Li H. Liu, South Williamsport, PA US
Patent application number | Description | Published |
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20080276411 | Wall hanging vacuum cleaner - A new vacuum cleaner/bracket combination has a bracket that mates with an indented side on a vacuum cleaner or blower. The indented side has a downwardly-facing upper lip portion and a laterally-facing side lip portion. There is an upper groove portion behind the downwardly-facing upper lip portion, and a side groove portion behind the side lip portion. The bracket has an upper rim portion that is configured to fit within the upper groove portion on the indented side. A side rim portion on the bracket is positioned below the upper rim portion. It is configured to fit within the side groove portion on the indented side when the upper rim portion on the bracket fits within the upper groove portion. | 11-13-2008 |
20110107547 | Combination vacuum cleaner, dolly, and mounting bracket - The disclosed bracket can be used to hang vacuum cleaners that have a detachable dolly. A plate on the bracket mounts to a wall. A stem portion fits within a slot on the dolly. Lower wall segments on the stem portion extend from the wall plate and have vertical outer edges. Intermediate wall segments extend between the lower wall segments and upper wall segments that have lower horizontal limits that are closer together than the lower wall segments are, are positioned laterally outwards from the stem portion, and taper toward each other above their lower limits. Side rim portions extend from the upper wall segments and fit within grooves on the vacuum cleaner. The outer edges of the lower wall segments are farther apart than the inner edges of the side rim portions are, and closer together than the outer edges of the side rim portions are. | 05-12-2011 |
20130007984 | Vacuum Cleaner with Recirculated Cooling Air - A vacuum cleaner comprising a receptacle having a working air inlet and an associated filter, the filter in communication with and downstream from the working air inlet, is disclosed. The vacuum cleaner further includes a housing containing a motor and having a cooling air outlet from the motor and a working air outlet, the working air outlet in communication with the working air inlet of the receptacle through a working air impeller, wherein the cooling air is directed to the receptacle, and the cooling air passes through the filter before exiting the working air outlet of the housing. | 01-10-2013 |
20130276262 | Vacuum Cleaner with Screen Cage - A vacuum cleaner has a screen cage that is permanently attached to a lid that fits on a receptacle. The screen cage has multiple layers of screens with different screen sizes, including an inner support that has greater rigidity and larger apertures that the primary screen, and an outer screen that also has greater rigidity and larger apertures than the primary screen, and is made of a different material than the support. A replaceable filter mounts to a power head that can be removed from the lid while the lid remains attached to the receptacle, and nests in the screen cage. A thermal cutoff shuts the vacuum cleaner off when the temperature of air in a part of the flowpath exceeds a limit. | 10-24-2013 |
Liming Liu, Upper Dublin, PA US
Patent application number | Description | Published |
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20090324614 | FC RECEPTOR BINDING PROTEINS - This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders. | 12-31-2009 |
20130045218 | FC RECEPTOR BINDING PROTEINS - This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders. | 02-21-2013 |
20130078262 | FC RECEPTOR BINDING PROTEINS - This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders. | 03-28-2013 |
20140248287 | FC RECEPTOR BINDING PROTEINS - This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders. | 09-04-2014 |
Nannan Liu, Collegeville, PA US
Patent application number | Description | Published |
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20080214640 | Thrombopoietin mimetics - Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative. | 09-04-2008 |
20090155203 | THROMBOPOIETIN MIMETICS - Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative. | 06-18-2009 |
20090176746 | THROMBOPOIETIN MIMETICS - Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative. | 07-09-2009 |
20090176973 | THROMBOPOIETIN MIMETICS - Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative. | 07-09-2009 |
Qindu Liu, Upper Darby, PA US
Qingdu Liu, Bala Cynwyd, PA US
Patent application number | Description | Published |
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20090286737 | ERBB INTERFACE PEPTIDOMIMETICS AND METHODS OF USE THEREOF - Peptides, mimetics and antibodies of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are described. Methods of using such antibodies, peptides, and mimetics in therapeutic, prophylactic, imaging and diagnostic applications are disclosed. | 11-19-2009 |
20100076174 | ErbB Interface Peptidomimetics And Methods Of Use Thereof - Peptides, mimetics and antibodies of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are described. Methods of using such antibodies, peptides, and mimetics in therapeutic, prophylactic, imaging and diagnostic applications are disclosed. | 03-25-2010 |
20100120688 | ErbB Interface Peptidomimetics And Methods Of Use Thereof - Peptides, mimetics and antibodies of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are described. Methods of using such antibodies, peptides, and mimetics in therapeutic, prophylactic, imaging and diagnostic applications are disclosed. | 05-13-2010 |
20100239587 | ErbB Interface Peptidomimetics And Methods Of Use Thereof - Peptides, mimetics and antibodies of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are described. Methods of using such antibodies, peptides, and mimetics in therapeutic, prophylactic, imaging and diagnostic applications are disclosed. | 09-23-2010 |
20130217857 | ERBB INTERFACE PEPTIDOMIMETICS AND METHODS OF USE THEREOF - Peptides, mimetics and antibodies of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are described. Methods of using such antibodies, peptides, and mimetics in therapeutic, prophylactic, imaging and diagnostic applications are disclosed. | 08-22-2013 |
Qingjie Liu, Newtown, PA US
Patent application number | Description | Published |
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20100160303 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS - Compounds having the formula (I), and enantiomers, and diastereomers, pharmaceutically-acceptable salts, thereof, | 06-24-2010 |
20120058988 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS - The present invention provides compounds of Formula (I) | 03-08-2012 |
20120058996 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS - Compounds having the formula (I), and enantiomers, and diastereomers, pharmaceutically-acceptable salts, thereof, | 03-08-2012 |
20130096118 | CARBOLINE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS - Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof, formula (I) are useful as kinase modulators, including Btk modulation. | 04-18-2013 |
20140378475 | SUBSTITUTED TETRAHYDROCARBAZOLE AND CARBAZOLE CARBOXAMIDE COMPOUNDS - Disclosed are compounds of Formula (I) | 12-25-2014 |
Ronggang Liu, King Of Prussia, PA US
Patent application number | Description | Published |
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20100113444 | PROLYL HYDROXYLASE INHIBITORS - The invention described herein relates to certain pyrimidinetrione N-substituted glycine derivatives of formula (I), (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example. | 05-06-2010 |
20110034499 | SPIROINDOLINES AS MODULATORS OF CHEMOKINE RECEPTORS - The present invention relates to a compound of the following formula: | 02-10-2011 |
20110124671 | SPIROINDENES AND SPIROINDANES AS MODULATORS OF CHEMOKINE RECEPTORS - The present invention relates to a compound of the following formula: | 05-26-2011 |
20130072487 | PROLYL HYDROXYLASE INHIBITORS - The invention described herein relates to certain pyrimidinetrione N-substituted glycine derivatives of formula (I) | 03-21-2013 |
Ruiyan Liu, Yardley, PA US
Patent application number | Description | Published |
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20090093472 | ORTHO PYRROLIDINE, BENZYL-SUBSTITUTED HETEROCYCLE CCR1 ANTAGONISTS FOR AUTOIMMUNE DISEASES & INFLAMMATION - Compounds of the formula | 04-09-2009 |
20100173823 | ALPHA2C ADRENORECEPTOR AGONISTS - In its many embodiments, the present invention relates to a novel class of phenylmorpholine and phenylthiomorpholine compounds useful as α2C adrenergic receptor agonists, pharmaceutical compositions containing the compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the α2C adrenergic receptor agonists using such compounds or pharmaceutical compositions. | 07-08-2010 |
Shaiw Wen Liu, Honeybrook, PA US
Patent application number | Description | Published |
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20110200625 | PHARMACEUTICAL COMPOSITION - A nonirritant, thickened pharmaceutical composition comprising a drug which is normally solid and which has anti-angiogenesis properties and/or immunosuppressant properties, a normally solid dermal penetration-facilitator for the drug, a solvent which is capable of dissolving the drug and the facilitator; and a thickening agent. | 08-18-2011 |
20130324567 | RESTORATION OF HAIR - A nonirritant composition which is useful in restoring hair and which comprises a normally solid, water-insoluble hair restorer, for example, minoxidil, a normally solid Hsieh dermal penetration-facilitator for the hair restorer, for example, pentadecalactone, and a solvent or co-solvent in which the hair restorer and the facilitator are solubilized and which does not impart to the composition irritant properties, and wherein, upon application to the surface of the skin of a recipient, the hair restorer penetrates the dermal layer of the skin and with minimal systemic delivery of the hair restorer into the blood stream of the recipient. | 12-05-2013 |
Tie Liu, Emmaus, PA US
Patent application number | Description | Published |
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20090275322 | PREVENTION OF AUDIO POP IN A DIGITAL AUDIO DEVICE - An electronic audio device with a digital audio output channel in which an amplifier output voltage is gradually ramped up and down to avoid causing a popping sound when the device is turned on and off. This is accomplished without employing any additional hardware, by incrementally changing a digital input word applied to a digital audio source, such as a DSP, so as to gradually change the amplifier output voltage between a minimum, such as zero volts, and a DC working voltage. On powering up, the amplifier is only turned on after the digital word is applied, but while it still results in a minimum amplifier output, and on powering down the amplifier is turned off after it's output has been ramped down, but before removing the digital input word. Sources and output channels can also be switched over by powering down, and then powering up, following the same method. | 11-05-2009 |
Wansheng Liu, State College, PA US
Patent application number | Description | Published |
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20100009374 | SIRE EARLY SELECTION FOR MALE FERTILITY USING SINGLE NUCLEOTIDE POLYMORPHISMS (SNPS) OF THE DAZL GENE - Methods and materials for identifying bovine males which will produce semen which will exhibit a higher rate of successfully impregnation by either artificial insemination or natural mating. The method employs SNPs that have been identified in the bDAZL gene which are associated with enhanced (or decreased) male fertility in bovine males and haplotypes formed from such SNPs. The method herein can be used to identify male dairy or beef cattle. The method herein can be applied to bovine animals at an appropriate time and particularly at birth or in utero. The invention further provides kits for conduction assays to assess bovine male fertility/infertility. The invention additionally provides a method of breeding cattle employing the methods and materials herein. | 01-14-2010 |
Wenjun Liu, King Of Prussia, PA US
Patent application number | Description | Published |
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20080264855 | METHOD AND APPARATUS FOR TREATING WASTEWATER - This invention is directed to a wastewater treatment system having a fluidizable media carrying anoxic bacteria in a first treatment zone and a filter membrane positioned in a second treatment zone. A wastewater is contacted with the fluidizable media and further contacted with air and a filter membrane. | 10-30-2008 |
20080314829 | Dynamic Control of Membrane Bioreactor System - A method of controlling the operating parameters of a membrane bioreactor system, the method including the steps of determining a control algorithm based on the relationship between the value of a parameter of the influent provided to the membrane bioreactor system and an optimal performance measurement parameter of the system and controlling one or more operating parameters of the membrane bioreactor system using the determined control algorithm. | 12-25-2008 |
20090026120 | METHOD AND APPARATUS FOR TREATING WASTEWATER - This invention is directed to a wastewater treatment system having a fluidizable media carrying anoxic bacteria in a first treatment zone and a filter membrane positioned in a second treatment zone. A wastewater is contacted with the fluidizable media and further contacted with air and a filter membrane. | 01-29-2009 |
20090090670 | WASTEWATER TREATMENT SYSTEM AND METHOD - The invention is directed to a wastewater treatment system having an anoxic biological treatment zone, an aerobic biological treatment zone and a separator. The concentration of oxygen in streams within the system is strategically managed for improved removal of nutrient from the wastewater. A source of biodegradable carbon may be introduced to reduce the concentration of oxygen within the system. An effective treatment time under anoxic or aerobic conditions may further be varied. | 04-09-2009 |
20100170847 | MEMBRANE CLEANING USING AN AIRLIFT PUMP - A membrane module ( | 07-08-2010 |
Wenjun Liu, Wayne, PA US
Patent application number | Description | Published |
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20100300968 | MEMBRANE CLEANING WITH PULSED GAS SLUGS - Aspects and embodiments of the present application are direction to systems and methods for treating fluids and to systems and methods for cleaning membrane modules used in the treatment of fluids. Disclosed herein is a membrane filtration system and a method of operating same. The membrane filtration system comprises a plurality of membrane modules positioned in a feed tank, at least one of the membrane modules having a gas slug generator positioned below a lower header thereof, the gas slug generator configured and arranged to deliver a gas slug along surfaces of membranes within the at least one of the membrane modules and a global aeration system configured to operate independently from an aeration system providing a gas to the gas slug generator, the global aeration system configured and arranged to induce a global circulatory flow of fluid throughout the feed tank. | 12-02-2010 |
20110089105 | HYBRID AEROBIC AND ANAEROBIC WASTEWATER AND SLUDGE TREATMENT SYSTEMS AND METHODS - A hybrid method and system of treating wastewater with reduced energy usage is disclosed. The treatment system has a sorption system, an anaerobic digester that digests or converts at least a portion of the solids or sludge from the sorption system, and an aerobic treatment tank that partially reduces oxygen demand of a portion of the sludge from the sorption tank. | 04-21-2011 |
20110203992 | HYBRID AEROBIC AND ANAEROBIC WASTEWATER AND SLUDGE TREATMENT SYSTEMS AND METHODS - A hybrid method and system of treating wastewater with reduced energy usage is disclosed. The treatment system has a sorption system, an anaerobic digester that digests or converts at least a portion of the solids or sludge from the sorption system, and an aerobic treatment tank that partially reduces oxygen demand of a portion of the sludge from the sorption tank. | 08-25-2011 |
20110259821 | Methods and Systems for Treating Wastewater - A method and system of treating wastewater is disclosed. The treatment system has a nitrification-denitrification system comprising a sorption system, a biofilm system, and an anaerobic digester that digests or converts at least a portion of the solids or sludge from the sorption system and biofilm system. | 10-27-2011 |
20120043277 | CONTACT-STABILIZATION/PRIME-FLOAT HYBRID - Systems and methods for treating wastewater including a dissolved air flotation operation performed upon a portion of a mixed liquor output from a contact tank prior to the mixed liquor entering a biological treatment tank. | 02-23-2012 |
20120285885 | MEMBRANE CLEANING WITH PULSED GAS SLUGS - Aspects and embodiments of the present application are direction to systems and methods for treating fluids and to systems and methods for cleaning membrane modules used in the treatment of fluids. Disclosed herein is a membrane filtration system and a method of operating same. The membrane filtration system comprises a plurality of membrane modules positioned in a feed tank, at least one of the membrane modules having a gas slug generator positioned below a lower header thereof, the gas slug generator configured and arranged to deliver a gas slug along surfaces of membranes within the at least one of the membrane modules. The membrane filtration system may further comprise a global aeration system configured to operate independently from an aeration system providing a gas to the gas slug generator. The global aeration system may be configured and arranged to induce a global circulatory flow of fluid throughout the feed tank. | 11-15-2012 |
20140021130 | HYBRID AEROBIC AND ANAEROBIC WASTEWATER AND SLUDGE TREATMENT SYSTEMS AND METHODS - A hybrid method and system of treating wastewater with reduced energy usage is disclosed. The treatment system has a sorption system, an anaerobic digester that digests or converts at least a portion of the solids or sludge from the sorption system, and an aerobic treatment tank that partially reduces oxygen demand of a portion of the sludge from the sorption tank. | 01-23-2014 |
20140027374 | HYBRID AEROBIC AND ANAEROBIC WASTEWATER AND SLUDGE TREATMENT SYSTEMS AND METHODS - A hybrid method and system of treating wastewater with reduced energy usage is disclosed. The treatment system has a sorption system, an anaerobic digester that digests or converts at least a portion of the solids or sludge from the sorption system, and an aerobic treatment tank that partially reduces oxygen demand of a portion of the sludge from the sorption tank. | 01-30-2014 |
20140034573 | HYBRID AEROBIC AND ANAEROBIC WASTEWATER AND SLUDGE TREATMENT SYSTEMS AND METHODS - A hybrid method and system of treating wastewater with reduced energy usage is disclosed. The treatment system has a sorption system and an anaerobic digester that digests or converts at least a portion of the solids or sludge from the sorption system. | 02-06-2014 |
20140076799 | Methods and Systems for Treating Wastewater - A method and system of treating wastewater is disclosed. The treatment system has a nitrification-denitrification system comprising a sorption system, a biofilm system, and an anaerobic digester that digests or converts at least a portion of the solids or sludge from the sorption system and biofilm system. | 03-20-2014 |
20140175009 | HYBRID AEROBIC AND ANAEROBIC WASTEWATER AND SLUDGE TREATMENT SYSTEMS AND METHODS - A hybrid method and system of treating wastewater with reduced energy usage is disclosed. The treatment system has a sorption system, an anaerobic digester that digests or converts at least a portion of the solids or sludge from the sorption system, and an aerobic treatment tank that partially reduces oxygen demand of a portion of the sludge from the sorption tank. | 06-26-2014 |
20140263010 | HYBRID AEROBIC AND ANAEROBIC WASTEWATER AND SLUDGE TREATMENT SYSTEMS AND METHODS - A hybrid method and system of treating wastewater with reduced energy usage is disclosed. The treatment system has a sorption system, an anaerobic digester that digests or converts at least a portion of the solids or sludge from the sorption system, and an aerobic treatment tank that partially reduces oxygen demand of a portion of the sludge from the sorption tank. | 09-18-2014 |
20140367330 | WASTEWATER TREATMENT PROCESS THAT UTILIZES GRANULAR SLUDGE TO REDUCE COD CONCENTRATION IN WASTEWATER - A wastewater treatment process that employs anaerobic granular sludge or biomass to remove chemical oxygen demand (COD) from the wastewater. Certain constituents, such as COD, nitrogen, calcium, other dissolved solids, suspended solids, can impair the effectiveness of the granular biomass. Thus, the process employs treatment units to remove these inhibiting constituents to produce a treated effluent or stream. At least a portion of the treated effluent is recycled and mixed with the influent wastewater to reduce the concentration of these inhibiting constituents. | 12-18-2014 |
Xiang-Qian Liu, Norristown, PA US
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20080227032 | ENVIRONMENTAL FRIENDLY PHOTOACID GENERATORS (PAGs) WITH NO PERFLUOROOCTYL SULFONATES - Novel classes of ionic photoacid generator (PAGs) compounds having relatively environmentally friendly anions with no perfluorooctyl sulfonate (no-PFOS) are provided and photoresist composition that comprise such compounds. The new PAGs produce a photoacid having a short or no perfluoro alkyl chain (i.e., no-PFOS) attached to a variety of functional groups. The PAGs of the invention are useful as photoactive component in the chemically amplified resist compositions used for microfabrication. | 09-18-2008 |
20110262861 | PHOTOSENSITIVE COMPOSITION - Photoresist compositions and methods suitable for depositing a thick photoresist layer in a single coating application are provided. Such photoresist layers are particularly suitable for use in chip scale packaging, for example, in the formation of metal bumps. | 10-27-2011 |
Xiaoli Liu, State College, PA US
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20090125238 | Method for Mechanical and Capillary Seal Analysis of a Hydrocarbon Trap - Method for making a probabilistic determination of total seal capacity for a hydrocarbon trap, simultaneously considering both capillary entry pressure and mechanical seal capacity, and where capillary entry pressure is estimated by relating it directly to the buoyancy pressure applied by the hydrocarbon column to the top seal. The method thus considers the substantial uncertainty associated with input parameters, which uncertainty limits the utility of such analyses for robust hydrocarbon column height and fluid contact predictions. The method disclosed for estimating seal capillary entry pressure, the requisite input parameter for capillary seal capacity analysis, by inverting trap parameters avoids the need for direct measurement by mercury injection capillary capacity tests on small pieces of rock, which test results often are not available for all desired locations nor are they necessarily representative of adjacent rocks in the seal. | 05-14-2009 |
Xiaoming Liu, Orefield, PA US
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20090041971 | POLARIZER FILMS AND METHODS OF MAKING THE SAME - In general, in one aspect, the invention features an article that includes a layer including a plurality of spaced-apart portions of a first material extending along a first direction. The layer transmits about 20% or more of light of wavelength λ having a first polarization state incident on the layer along a path. The layer transmits about 2% or less of light of wavelength λ having a second polarization state incident on the layer along the path, the first and second polarization states being orthogonal. For wavelength λ, the first material has a refractive index of 1.8 or more and an extinction coefficient of 1.8 or more, and λ is 300 nm or less. | 02-12-2009 |
20090053655 | Methods for forming patterned structures - In general, in a first aspect, the invention features a method that includes forming a first layer comprising a first material over a surface of a second layer, wherein forming the first layer includes sequentially forming a plurality of monolayers of the second material over the surface of the second layer, the second layer comprises a plurality of rows of a second material extending along a first direction and spaced from one another in a second direction orthogonal to the first direction, and the first layer conforms to the surface of the second layer. The method further includes removing portions of the first layer to produce a plurality of rows of the first material extending along the first direction and spaced from one another in the second direction and removing portions of a third layer comprising a third material, where the portions correspond to intervals between the second plurality of rows so that removing the portions forms a plurality of rows of the third material extending along the first direction and spaced apart from one another. The first and second materials are different. | 02-26-2009 |
Xiaoyu Liu, Pittsburgh, PA US
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20110101788 | Wireless Energy Transfer System - A wireless energy transfer system includes a first energy transfer unit having at least one resonant frequency, a second energy transfer unit having the at least one resonant frequency, and a load. The first wireless energy transfer unit includes a first coil magnetically coupled to a first wireless energy transfer cell, and the second wireless energy transfer unit includes a second coil magnetically coupled to a second wireless energy transfer cell. The first coil receives first energy and through the magnetic coupling between the first coil and the first wireless energy transfer cell, the first wireless energy transfer cell is caused to generate second energy, wherein the second wireless energy transfer cell receives the second energy and through the magnetic coupling between the second wireless energy transfer cell and the second coil, the second coil is caused to provide third electromagnetic wave energy to the load. | 05-05-2011 |
20130181048 | METHOD AND APPARATUS FOR STORING AND TRACKING INFORMATION RELATING TO A MEDICAL IMPLANT DEVICE - A system for storing information relating to a medical implant device implanted in a patient includes a credit card sized card device structured to be carried by the patient external to the patient's body. The card device includes a wireless transponder device securely storing information relating to at least one of the medical implant and the patient. The system also includes a reader device structured to selectively and securely read the information from the wireless transponder device. In one implementation, the reader device is able to selectively and securely read the information from the wireless transponder device using a direct electrical connection (e.g., using transcutaneous contact) without an air interface. | 07-18-2013 |
20140062212 | Wireless Energy Transfer System - A wireless energy transfer system includes a first energy transfer unit having at least one resonant frequency, a second energy transfer unit having the at least one resonant frequency, and a load. The first wireless energy transfer unit includes a first coil magnetically coupled to a first wireless energy transfer cell, and the second wireless energy transfer unit includes a second coil magnetically coupled to a second wireless energy transfer cell. The first coil receives first energy and through the magnetic coupling between the first coil and the first wireless energy transfer cell, the first wireless energy transfer cell is caused to generate second energy, wherein the second wireless energy transfer cell receives the second energy and through the magnetic coupling between the second wireless energy transfer cell and the second coil, the second coil is caused to provide third electromagnetic wave energy to the load. | 03-06-2014 |
Xinping Liu, Doylestown, PA US
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20110075156 | RANGE FINDER - A system and method for measuring a height of objects on a moving surface comprising providing a linear image sensor positioned transverse to a direction of travel of the moving surface, and at least one light source positioned collinear to the linear image sensor and proximate to an edge of the moving surface so that the light source projects a unique patterned light sequence across a width of the moving surface, detecting a transverse shift in a portion of the unique patterned light sequence with respect to the direction of travel of the moving surface as an object passes through the unique patterned light sequence, determining an amount of shift of the portion of the unique patterned light sequence, and determining a height of the object based on the portion of the unique patterned light sequence shift. | 03-31-2011 |
20140319219 | SCANNING SYSTEM - A scanning system has a collimated light source and a movable reflective surface. The surface receives light from the light source, reflects the received light to a target surface, receives light reflected from the target surface, and reflects this light to a detector. An aperture disposed between the reflective surface and the target surface has a non-transmissive portion with a width in a direction perpendicular to the laser scan direction that varies over the scan direction. | 10-30-2014 |
Xinyin Liu, Exton, PA US
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20100041770 | POLYMER-CERAMIC COMPOSITE AND METHOD - Methods and devices are shown for a composite material that is easily applied to a surface such as a bone defect in need of filling or reinforcement, etc. The composite material provides good mechanical properties such as compressive strength upon curing in the presence of water. Selected materials and methods as described are further bioabsorbable with absorption rates that are controllable to provide desired morphology over time. In selected embodiments a pharmaceutical agent further provides benefits such as bone growth, infection resistance, pain management, etc. | 02-18-2010 |
Yixiong Liu, Greensburg, PA US
Patent application number | Description | Published |
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20090004440 | CUTTING INSERT WITH A WEAR-RESISTANT COATING SCHEME EXHIBITING WEAR INDICATION AND METHOD OF MAKING THE SAME - A coated cutting insert for use in a chip-forming material removal operation wherein the coated cutting insert includes a substrate that has a flank surface and a rake surface and the flank surface intersects the rake surface to form a cutting edge at the intersection. There is a wear-resistant coating scheme that adheres to at least a portion of the substrate. The wear-resistant coating scheme includes one or more coating layers of one or more of alumina, hafnia and zirconia. There is a wear indicating coating that adheres to at least a portion of the wear-resistant coating scheme. The wear indicating coating includes M(O | 01-01-2009 |
20090004449 | Cutting insert with a wear-resistant coating scheme exhibiting wear indication and method of making the same - A coated cutting insert for use in a chip-forming material removal operation wherein the coated cutting insert includes a substrate that has a flank surface and a rake surface and the flank surface intersects the rake surface to form a cutting edge at the intersection. There is a wear-resistant coating scheme that adheres to at least a portion of the substrate. The wear-resistant coating scheme includes one or more coating layers of one or more of alumina, hafnia and zirconia. There is a wear indicating coating that adheres to at least a portion of the wear-resistant coating scheme. The wear indicating coating includes M(O | 01-01-2009 |
20090155559 | Coated article with nanolayered coating scheme - A coated article that includes a substrate and a wear-resistant coating scheme. The coated article may be a cutting insert shown to improve performance in chip-forming material removal operations or a wear-resistant component used in chipless forming operations. The wear-resistant coating scheme has an underlayer and top layer containing aluminum, chromium, and nitrogen. The coating scheme also includes a mediate multi-periodicity nanolayer coating scheme containing titanium, aluminum, chromium and nitrogen. The mediate multi-periodicity nanolayer coating scheme includes a plurality of sets of alternating layer arrangements. Each one of the alternating layer arrangements has a base layer comprising titanium, aluminum and nitrogen and a nanolayer region having a plurality of sets of alternating nanolayers. Each set of alternating nanolayers has one nanolayer having aluminum, chromium, titanium and nitrogen and another nanolayer having aluminum, chromium, titanium and nitrogen. The base layer has a base layer thickness and the nanolayer region has a nanolayer region thickness. The base layer thickness is smaller than the nanolayer region thickness. | 06-18-2009 |
20110081539 | Aluminum Titanium Nitride Coating and Method of Making Same - Hard coatings and methods of making the hard coatings comprising aluminum titanium nitride which are usable on cutting tools are disclosed. The coatings include at least one aluminum titanium nitride layer having between about 0 and about 15 weight percent hexagonal phase and a composition of (Al | 04-07-2011 |
20110107679 | COATED CUTTING INSERT AND METHOD FOR MAKING THE SAME - A coated cutting insert for removing material from a workpiece that includes a substrate is disclosed. A wear-resistant coating on the substrate that includes an α-alumina layer and a Zr— or Hf— carbonitride outer layer deposited on the α-alumina layer. The Zr— or Hf— carbonitride outer layer is subjected to a post-coat wet blasting treatment. The wet blasting changes the stress condition of the exposed alumina coating layer from an initial tensile stress condition to a compressive stress condition. | 05-12-2011 |
20110293909 | Multilayer Nitride Hard Coatings - A wear resistant multilayer nitride hard coating for substrates. The hard coating includes a first layer of titanium aluminum nitride and a second layer comprising a plurality of sublayer groups. Each sublayer group includes a first sublayer of titanium silicon nitride and a second sublayer of titanium aluminum nitride. The composition of the titanium aluminum nitride, both in the first layer and in the sublayer groups, is (Ti | 12-01-2011 |
20120128955 | COATED CUTTING INSERT AND METHOD FOR MAKING THE SAME - A coated cutting insert for removing material from a workpiece that includes a substrate is disclosed. A wear-resistant coating on the substrate that includes an alumina layer and a Zr- or Hf-carbonitride outer layer deposited on the alumina layer. The Zr- or Hf-carbonitride outer layer is subjected to a post-coat wet blasting treatment. The wet blasting changes the stress condition of the exposed alumina coating layer from an initial tensile stress condition to a compressive stress condition. | 05-24-2012 |
20120201615 | Cubic Aluminum Titanium Nitride Coating and Method of Making Same - Coated cutting tools are disclosed which have a hard coating that includes at least one aluminum titanium nitride layer having a single phase structure of B1 cubic phase and a composition of (Al | 08-09-2012 |
20120225285 | Coated Substrates and Methods of Making Same - Coated substrates having high wear resistant coatings are disclosed. The coatings include at least one layer of either titanium oxycarbonitride or titanium aluminum oxycarbonitride, such that the layer has an oxygen to titanium atomic percent ratio in the range of about 0.01 to about 0.09 and an aluminum to titanium atomic percent ratio in the range of about 0 to about 0.1. The coatings have a hardness to Young's modulus ratio of at least 0.06. The substrate may be a cutting insert. Methods of making such coated substrates are also disclosed in which layers comprising titanium oxycarbonitride or titanium aluminum oxycarbonitride are deposited by medium temperature chemical vapor deposition (MT-CVD) on substrates in the temperature range of about 750 to about 950° C. using a mixture of gases wherein the ratio of the hydrogen gas to the nitrogen gas is greater than 5. | 09-06-2012 |
20120237794 | ALUMINUM OXYNITRIDE COATED ARTICLE AND METHOD OF MAKING THE SAME - A coated article such as a coated cutting tool or coated wear part, which includes a substrate and a coating scheme on the substrate. The coating scheme has a titanium-containing coating layer, and an aluminum oxynitride coating layer on the titanium-containing coating layer. The aluminum oxynitride includes a mixture of phases having a hexagonal aluminum nitride type structure (space group: P63mc), a cubic aluminum nitride type structure (space group: Fm-3m), and optionally amorphous structure. The aluminum oxynitride coating layer has a composition of aluminum in an amount between about 20 atomic percent and about 50 atomic percent, nitrogen in an amount between about 40 atomic percent and about 70 atomic percent, and oxygen in an amount between about 1 atomic percent and about 20 atomic percent. The method of making the coated article includes a step of providing a substrate and depositing an aluminum oxynitride coating layer from a gaseous mixture that includes nitrogen, aluminum tri-chloride, ammonia, carbon dioxide, hydrogen chloride, optionally carbon monoxide, optionally argon, and hydrogen. | 09-20-2012 |
20120244342 | CVD COATED POLYCRYSTALLINE c-BN CUTTING TOOLS - In one aspect, the present invention provides coated cutting tools comprising a PcBN substrate wherein a layer of single phase α-alumina is deposited by chemical vapor deposition directly on one or more surfaces of the substrate. | 09-27-2012 |
20130011692 | COATED ARTICLE HAVING YTTRIUM-CONTAINING COATINGS APPLIED BY PHYSICAL VAPOR DEPOSITION AND METHOD FOR MAKING THE SAME - A coated article has a substrate and a coating scheme, which has a PVD coating region. The PVD coating region contains aluminum, yttrium, nitrogen and at least one element selected from the group of titanium, zirconium, hafnium, vanadium, niobium, tantalum, chromium, molybdenum, tungsten and silicon. The sum of the aluminum and yttrium contents is between about 3 atomic percent and about 55 atomic percent of the sum of aluminum, yttrium and the other elements. The yttrium content is between about 0.5 atomic percent and about 5 atomic percent of the sum of aluminum, yttrium and the other elements. There is also a method of making the coated article that includes steps of providing the substrate and depositing the above coating scheme with the PVD coating region. | 01-10-2013 |
20130065081 | MULTILAYER COATED WEAR-RESISTANT MEMBER AND METHOD FOR MAKING THE SAME - A coated wear-resistant member, as well as a method for making the same, includes a substrate and a coating scheme. The coating scheme has a region of alternating coating sublayers. One coating sublayer is Ti | 03-14-2013 |
20130136941 | FUNCTIONALLY GRADED COATING - In one aspect, composite articles are described comprising multifunctional coatings. A composite article described herein, in some embodiments, comprises a substrate and a coating adhered to the substrate, the coating comprising an inner layer and an outer layer, the inner layer comprising a presintered metal or alloy and the outer layer comprising particles disposed in a metal or alloy matrix. | 05-30-2013 |
20130157023 | MULTILAYER NITRIDE HARD COATINGS - A wear resistant multilayer nitride hard coating for substrates. The hard coating includes a first layer of titanium aluminum nitride and a second layer comprising a plurality of sublayer groups. Each sublayer group includes a first sublayer of titanium silicon nitride and a second sublayer of titanium aluminum nitride. The composition of the titanium aluminum nitride, both in the first layer and in the sublayer groups, is (Ti | 06-20-2013 |
20130260035 | METHOD OF MAKING A COATED CERAMIC CUTTING INSERT - A coated ceramic cutting insert for removing material from a workpiece, as well as a method for making the same, that includes a ceramic substrate with a rake surface and at least one flank surface wherein a cutting edge is at the juncture therebetween. A wear-resistant coating scheme that includes an alumina-containing base coating layer region, which has at least one exposed alumina coating layer, deposited by chemical vapor deposition on the substantially all of the surfaces of the ceramic substrate that experience wear during removal of material from the workpiece. The exposed alumina coating layer exhibits a blasted stress condition ranging between about 50 MPa (tensile stress) and about −2 GPa (compressive) as measured by XRD using the Psi tilt method and the (024) reflection of alumina. The exposed alumina coating layer is the result of wet blasting a titanium-containing outer coating layer region from the surface of the alumina-containing base coating layer region. | 10-03-2013 |
20130302521 | METHOD OF MAKING ALUMINUM OXYNITRIDE COATED ARTICLE - A coated article such as a coated cutting tool or coated wear part, which includes a substrate and a coating scheme on the substrate. The coating scheme has a titanium-containing coating layer, and an aluminum oxynitride coating layer on the titanium-containing coating layer. The aluminum oxynitride includes a mixture of phases having a hexagonal aluminum nitride type structure (space group: P63mc), a cubic aluminum nitride type structure (space group: Fm-3m), and optionally amorphous structure. The aluminum oxynitride coating layer has a composition of aluminum in an amount between about 20 atomic percent and about 50 atomic percent, nitrogen in an amount between about 40 atomic percent and about 70 atomic percent, and oxygen in an amount between about 1 atomic percent and about 20 atomic percent. The method of making the coated article includes a step of providing a substrate and depositing an aluminum oxynitride coating layer from a gaseous mixture that includes nitrogen, aluminum tri-chloride, ammonia, carbon dioxide, hydrogen chloride, optionally carbon monoxide, optionally argon, and hydrogen. | 11-14-2013 |
20140208662 | GREEN COLORED REFRACTORY COATINGS FOR CUTTING TOOLS - In one aspect, coated cutting tools are described herein. A coated cutting tool described herein comprises a substrate and a coating adhered to the substrate, the coating comprising at least one composite layer deposited by chemical vapor deposition, the composite layer comprising an aluminum oxynitride phase, a metal oxide phase including zirconium oxide, a zirconium sulfur nitride phase and a metal oxynitride phase in addition to the aluminum oxynitride phase, the metal oxynitride phase comprising zirconium oxynitride. | 07-31-2014 |
20140271318 | METHODS OF MAKING METAL MATRIX COMPOSITE AND ALLOY ARTICLES - In one aspect, methods of making freestanding metal matrix composite articles and alloy articles are described. A method of making a freestanding composite article described herein comprises disposing over a surface of the temporary substrate a layered assembly comprising a layer of infiltration metal or alloy and a hard particle layer formed of a flexible sheet comprising organic binder and the hard particles. The layered assembly is heated to infiltrate the hard particle layer with metal or alloy providing a metal matrix composite, and the metal matrix composite is separated from the temporary substrate. Further, a method of making a freestanding alloy article described herein comprises disposing over the surface of a temporary substrate a flexible sheet comprising organic binder and powder alloy and heating the sheet to provide a sintered alloy article. The sintered alloy article is then separated from the temporary substrate. | 09-18-2014 |
20140271319 | CLADDED ARTICLES AND METHODS OF MAKING THE SAME - In one aspect, methods of making cladded articles are described herein. A method of making a cladded article, in some embodiments, comprises disposing over a surface of a metallic substrate a sheet comprising organic binder and powder metal or powder alloy having a solidus temperature at least 100° C. less than the metallic substrate and heating the powder metal or powder alloy to provide a sintered metal or sintered alloy cladding metallurgically bonded to the metallic substrate. | 09-18-2014 |
20140272391 | HARD COATINGS COMPRISING CUBIC PHASE FORMING COMPOSITIONS - Refractory coatings for cutting tool applications and methods of making the same are described herein which, in some embodiments, permit incorporation of increased levels of aluminum into nitride coatings while reducing or maintaining levels of hexagonal phase in such coatings. Coatings and methods described herein, for example, employ cubic phase forming compositions for limiting hexagonal phase in nitride coatings of high aluminum content. | 09-18-2014 |
20140272446 | WEAR-RESISTANT CLADDINGS - In one aspect, articles are described herein comprising wear-resistant claddings. An article described herein, in some embodiments, comprises a metallic substrate and a cladding adhered to the substrate, the cladding including a metal matrix composite layer comprising at least one hard particle tile having a pore structure infiltrated with matrix metal or matrix alloy. Infiltration of the pore structure of the hard particle tile by the matrix metal or alloy can render the tile fully dense or substantially fully dense. | 09-18-2014 |
20140287199 | COATINGS FOR CUTTING TOOLS - In one aspect, cutting tools are described having coatings adhered thereto which, in some embodiments, can demonstrate desirable wear resistance and increased cutting lifetimes. A coated cutting tool, in some embodiments, comprises a substrate and a coating adhered to the substrate, the coating comprising a polycrystalline layer of TiZrAl | 09-25-2014 |
20140287228 | COATED BODY WHEREIN THE COATING SCHEME INCLUDES A COATING LAYER OF TiAl2O3 AND METHOD OF MAKING THE SAME - A coated cutting insert and a method for making the same. The coated cutting insert has a substrate with a substrate surface. There is a backing coating scheme on the substrate surface, and a TiAl | 09-25-2014 |
20140287229 | COATINGS FOR CUTTING TOOLS - In one aspect, cutting tools are described having coatings adhered thereto which, in some embodiments, can demonstrate desirable wear resistance and increased cutting lifetimes. A coated cutting tool, in some embodiments, comprises a substrate and a coating adhered to the substrate, the coating comprising at least one Zr doped layer deposited by chemical vapor deposition comprising ZrAl | 09-25-2014 |
20140291036 | MULTILAYER STRUCTURED COATINGS FOR CUTTING TOOLS - In one aspect, cutting tools are described having coatings adhered thereto which, in some embodiments, can demonstrate desirable wear resistance and increased cutting lifetimes. A coated cutting tool described herein comprises a substrate and a coating adhered to the substrate, the coating having a multilayer structure including a plurality of structural units each comprising a bonding layer and an adjacent alumina layer, the alumina layer having a thickness of less than 0.5 μm and the bonding layer having a thickness less than 1 μm, the bonding layer comprising TiCN and TiAlOC. | 10-02-2014 |
20140342173 | FUNCTIONALLY GRADED COATING - In one aspect, composite articles are described comprising multifunctional coatings. A composite article described herein, in some embodiments, comprises a substrate and a coating adhered to the substrate, the coating comprising an inner layer and an outer layer, the inner layer comprising a presintered metal or alloy and the outer layer comprising particles disposed in a metal or alloy matrix. | 11-20-2014 |
20150050489 | LOW STRESS HARD COATINGS AND APPLICATIONS THEREOF - In one aspect, coated cutting tools are described herein. In some embodiments, a coated cutting tool comprises a substrate and a refractory layer deposited by PVD adhered to the substrate, the refractory layer comprising M | 02-19-2015 |
20150050490 | Low Stress Hard Coatings And Applications Thereof - In one aspect, coated cutting tools are described herein comprising a substrate and a coating comprising a refractory layer deposited by physical vapor deposition adhered to the substrate, the refractory layer comprising M | 02-19-2015 |
20150064431 | Refractory Coatings For Cutting Tools - In one aspect, cutting tools are described having coatings adhered thereto which, in some embodiments, demonstrate desirable wear resistance and increased cutting lifetimes. A coated cutting tool described herein comprises a substrate and a coating adhered to the substrate, the coating including a refractory layer comprising plurality of sublayer groups, a sublayer group comprising an aluminum oxynitride (AlON) sublayer or a composite AlON sublayer and an alumina (Al | 03-05-2015 |
Yixiong Liu, Latrobe, PA US
Patent application number | Description | Published |
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20100255345 | COATED PCBN CUTTING INSERT, COATED PCBN CUTTING TOOL USING SUCH COATED PCBN CUTTING INSERT, AND METHOD FOR MAKING THE SAME - A coated polycrystalline cubic boron nitride cutting insert useful in a cutting tool for removing material from a workpiece, and a method for making the same. The cutting insert including a polycrystalline cubic boron nitride substrate with a rake surface and at least one flank surface, and a cutting edge formed at the juncture between the rake surface and the flank surface. A wear-resistant coating scheme is on the polycrystalline cubic boron nitride substrate. The wear-resistant coating scheme includes the following coating layers. An inner coating layer region is on at least some of the rake surface and at least some of the flank surface of the polycrystalline cubic boron nitride substrate. An alumina-containing coating layer region, which has at least one exposed alumina coating layer, is on the inner coating layer region. The exposed alumina coating layer exhibiting a post-blasted stress condition with stress ranging between about 50 MPa (tensile stress) and about −2 GPa (compressive stress) as measured by XRD using the Psi tilt method and the (024) reflection of alumina. The exposed coating layer is the result of wet blasting an outer titanium-containing coating layer from the surface of the alumina-containing coating layer region. | 10-07-2010 |
20110064530 | COATED CERAMIC CUTTING INSERT AND METHOD FOR MAKING THE SAME - A coated ceramic cutting insert for removing material from a workpiece, as well as a method for making the same, that includes a ceramic substrate with a rake surface and at least one flank surface wherein a cutting edge is at the juncture therebetween. A wear-resistant coating scheme that includes an alumina-containing base coating layer region, which has at least one exposed alumina coating layer, deposited by chemical vapor deposition on the substantially all of the surfaces of the ceramic substrate that experience wear during removal of material from the workpiece. The exposed alumina coating layer exhibits a blasted stress condition ranging between about 50 MPa (tensile stress) and about −2 GPa (compressive) as measured by XRD using the Psi tilt method and the (024) reflection of alumina. The exposed alumina coating layer is the result of wet blasting a titanium-containing outer coating layer region from the surface of the alumina-containing base coating layer region. | 03-17-2011 |
Yuan Liu, Lansdale, PA US
Patent application number | Description | Published |
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20090117590 | Human calcium sensitive potassium channel beta3 subunit proteins, encoding nucleic acid and uses thereof - The present invention is directed to novel human DNA sequences encoding calcium sensitive potassium channel subunits β2, β3a, β3b, β3c, and β3d, the proteins encoded by the DNA sequences, vectors comprising the DNA sequences, host cells containing the vectors, and methods of identifying inhibitors and agonists of calcium sensitive potassium channels containing human β2, β3a, β3b, β3c, or β3d subunits and inhibitors and agonists of β3 gene transcription. | 05-07-2009 |
Zhan-Bin Liu, West Chester, PA US
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20080220143 | Production of Very Long Chain Polyunsaturated Fatty Acids in Oil Seed Plants - Oilseed plants which have been transformed to produce at least 8.0% arachidonic acid (ARA) as well as uses of oils and seeds obtained from such transformed plants in a variety of food and feed applications are described. | 09-11-2008 |
20110269983 | PRODUCTION OF VERY LONG CHAIN POLYUNSATURATED FATTY ACIDS IN OILSEED PLANTS - Oilseed plants which have been transformed to produce very long chain polyunsaturated fatty acids, recombinant constructs used in such transformations, methods for producing such fatty acids in a plant are described and uses of oils and seeds obtained from such transformed plants in a variety of food and feed applications are described. | 11-03-2011 |
20130263324 | METHODS FOR PRODUCING A COMPLEX TRANSGENIC TRAIT LOCUS - Methods for producing in a plant a complex transgenic trait locus comprising at least two altered target sequences in a genomic region of interest are disclosed. The methods involve the use of two or more double-strand-break-inducing agents, each of which can cause a double-strand break in a target sequence in the genomic region of interest which results in an alteration in the target sequence. Also disclosed are complex transgenic trait loci in plants. A complex transgenic trait locus comprises at least two altered target sequences that are genetically linked to a polynucleotide of interest. Plants, plant cells, plant parts, and seeds comprising one or more complex transgenic trait loci are also disclosed. | 10-03-2013 |
20140223606 | COMPOSITIONS AND METHODS COMPRISING SEQUENCES HAVING MEGANUCLEASE ACTIVITY - Compositions and methods comprising polynucleotides and polypeptides having meganuclease activity are provided. Further provided are nucleic acid constructs, yeast, plants, plant cells, explants, seeds and grain having the meganuclease sequences. Various methods of employing the meganuclease sequences are provided. Such methods include, for example, methods for producing a meganuclease with increased activity at a wide range of temperatures, methods for producing a yeast, plant, plant cell, explant or seed comprising a meganuclease with increased activity. | 08-07-2014 |
20140338070 | METHODS AND COMPOSITIONS FOR TARGETED INTEGRATION IN A PLANT - Compositions and methods are provided for the targeted integration of a polynucleotide sequence of interest into the genome of a plant or plant cell. The methods and compositions employ recognition sites for endonucleases and endonucleases in combination with site-specific recombination sites/recombinases to provide an effective system for establishing target sites within the genome of a plant, plant cell or seed. Once such target sites are established, a variety of methods can be employed to further modify the target sites such that they contain a variety of polynucleotides of interest. | 11-13-2014 |
20150082478 | PLANT GENOME MODIFICATION USING GUIDE RNA/CAS ENDONUCLEASE SYSTEMS AND METHODS OF USE - Compositions and methods are provided for genome modification of a target sequence in the genome of a plant or plant cell. The methods and compositions employ a guide RNA/Cas endonuclease system to provide an effective system for modifying or altering target sites within the genome of a plant, plant cell or seed. Also provided are compositions and methods employing a guide polynucleotide/Cas endonuclease system for genome modification of a nucleotide sequence in the genome of a cell or organism, for gene editing, and/or for inserting or deleting a polynucleotide of interest into or from the genome of a cell or organism. Once a genomic target site is identified, a variety of methods can be employed to further modify the target sites such that they contain a variety of polynucleotides of interest. Breeding methods and methods for selecting plants utilizing a two component RNA guide and Cas endonuclease system are also disclosed. Compositions and methods are also provided for editing a nucleotide sequence in the genome of a cell. | 03-19-2015 |
Zhendong Liu, King Of Prussia, PA US
Patent application number | Description | Published |
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20100112906 | Chemical mechanical polishing composition and methods relating thereto - A method for chemical mechanical polishing of a substrate comprising a germanium-antimony-tellurium chalcogenide phase change alloy using a chemical mechanical polishing composition comprising water; 1 to 40 wt % colloidal silica abrasive particles having an average particle size of ≦50 nm; and 0 to 5 wt % quarternary ammonium compound; wherein the chemical mechanical polishing composition is oxidizer free and chelating agent free; and, wherein the chemical mechanical polishing composition has a pH >6 to 12. | 05-06-2010 |
20100151683 | Chemical mechanical polishing composition and methods relating thereto - A method for chemical mechanical polishing of a substrate comprising a barrier material in the presence of at least one of an interconnect metal and a low-k dielectric material using a chemical mechanical polishing composition comprising water; 1 to 40 wt % abrasive having an average particle size of ≦100 nm; 0.001 to 5 wt % quaternary compound; a material having a formula (I): | 06-17-2010 |
20110111595 | Chemical mechanical polishing composition and methods relating thereto - A chemical mechanical polishing composition useful for chemical mechanical polishing of a substrate, wherein the substrate comprises a silicon oxide material and a silicon nitride material; and methods of making and using the chemical mechanical polishing composition. The chemical mechanical polishing composition comprises, as initial components: at least one of a first substance and a second substance; wherein the first substance is according to formula I | 05-12-2011 |
20110230048 | Method of polishing a substrate comprising polysilicon, silicon oxide and silicon nitride - A method for chemical mechanical polishing of a substrate is provided, comprising: providing a substrate, wherein the substrate comprises polysilicon, silicon oxide and silicon nitride; providing a chemical mechanical polishing composition, comprising, as initial components: water; an abrasive; an alkyl aryl polyether sulfonate compound, wherein the alkyl aryl polyether sulfonate compound has a hydrophobic portion having an alkyl group bound to an aryl ring and a nonionic acyclic hydrophilic portion having 4 to 100 carbon atoms; and a substance according to formula I | 09-22-2011 |
20110230049 | Method of polishing a substrate comprising polysilicon and at least one of silicon oxide and silicon nitride - A method for chemical mechanical polishing of a substrate is provided, comprising: providing a substrate, wherein the substrate comprises polysilicon and at least one of silicon oxide and silicon nitride; providing a chemical mechanical polishing composition, comprising, as initial components: water; an abrasive; and an acyclic organosulfonic acid compound, wherein the acyclic organosulfonic acid compound has an acyclic hydrophobic portion having 6 to 30 carbon atoms and a nonionic acyclic hydrophilic portion having 10 to 300 carbon atoms; providing a chemical mechanical polishing pad with a polishing surface; moving the polishing surface relative to the substrate; dispensing the chemical mechanical polishing composition onto the polishing surface; and, abrading at least a portion of the substrate to polish the substrate; wherein at least some of the polysilicon is removed from the substrate; and, wherein at least some of the at least one of silicon oxide and silicon nitride is removed from the substrate. | 09-22-2011 |
20110230050 | METHOD OF POLISHING A SUBSTRATE COMPRISING POLYSILICON AND AT LEAST ONE OF SILICON OXIDE AND SILICON NITRIDE - A method for chemical mechanical polishing of a substrate is provided, comprising: providing a substrate, wherein the substrate comprises polysilicon and at least one of silicon oxide and silicon nitride; providing a chemical mechanical polishing composition, comprising, as initial components: water; an abrasive; and an alkyl aryl polyether sulfonate compound, wherein the alkyl aryl polyether sulfonate compound has a hydrophobic portion having an alkyl group bound to an aryl ring and a nonionic acyclic hydrophilic portion having 4 to 100 carbon atoms; providing a chemical mechanical polishing pad with a polishing surface; moving the polishing surface relative to the substrate; dispensing the chemical mechanical polishing composition onto the polishing surface; and, abrading at least a portion of the substrate to polish the substrate; wherein at least some of the polysilicon is removed from the substrate; and, wherein at least some of the at least one of silicon oxide and silicon nitride is removed from the substrate. | 09-22-2011 |
20110244685 | Method of chemical mechanical polishing a substrate with polishing composition adapted to enhance silicon oxide removal - A method for chemical mechanical polishing of a substrate is provided, comprising: providing a substrate, wherein the substrate comprises silicon oxide; providing a chemical mechanical polishing composition, comprising, as initial components: water; an abrasive; and a substance according to formula I | 10-06-2011 |
20120001118 | Polishing slurry for chalcogenide alloy - The invention provides a chemical mechanical polishing composition for chemical mechanical polishing of a chalcogenide phase change alloy substrate. The composition comprises by weight percent, water, 0.1 to 30 colloidal silica abrasive, at least one polishing agent selected from 0.05 to 5 halogen compound, 0.05 to 5 phthalic acid, 0.05 to 5 phthalic anhydride and salts, derivatives and mixtures thereof. The chemical mechanical polishing composition has a pH of 2 to less than 7. | 01-05-2012 |
20120003834 | Method Of Polishing Chalcogenide Alloy - The invention provides a method for chemical mechanical polishing of a substrate. The invention comprises providing a substrate, wherein the substrate comprises a chalcogenide phase change alloy and providing a chemical mechanical polishing composition, wherein the chemical mechanical polishing composition comprises, by weight percent, water, 0.1 to 30 abrasive, at least one polishing agent selected from 0.05 to 5 halogen compound, 0.05 to 5 phthalic acid, 0.05 to 5 phthalic anhydride and salts, derivatives and mixtures thereof and wherein the chemical mechanical polishing composition has a pH of 2 to less than 7. A chemical mechanical polishing pad polishes the substrate with the chemical mechanical polishing pad and the chemical mechanical polishing composition to selectively or non-selectively remove the chalcogenide phase change alloy from the substrate. | 01-05-2012 |
20120070989 | Stabilized, Concentratable Chemical Mechanical Polishing Composition And Method Of Polishing A Substrate - A chemical mechanical polishing composition, comprising, as initial components: water; an abrasive; a diquaternary substance according to formula (I), wherein each X is independently selected from N and P; wherein R | 03-22-2012 |
20120070990 | Slurry Composition Having Tunable Dielectric Polishing Selectivity And Method Of Polishing A Substrate - A chemical mechanical polishing slurry composition, comprising, as initial components: water; an abrasive; a halogenated quaternary ammonium compound according to formula (I), wherein R | 03-22-2012 |
20120258598 | Stabilized Chemical Mechanical Polishing Composition and Method of Polishing a Substrate - A chemical mechanical polishing composition, comprising, as initial components: water; 0.1 to 20 wt % abrasive having an average particle size of 5 to 50 nm; and, 0.001 to 1 wt % of an adamantyl substance according to formula (II): | 10-11-2012 |
Zhendong Liu, Prussia, PA US
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20100279507 | Method for chemical mechanical polishing a substrate - A method for chemical mechanical polishing of a substrate, comprising: providing a substrate, wherein the substrate comprises silicon dioxide; providing a chemical mechanical polishing composition, wherein the chemical mechanical polishing composition comprises: water, an abrasive; a diquaternary cation according to formula (I); and optionally a quaternary alkylammonium compound; providing a chemical mechanical polishing pad; creating dynamic contact at an interface between the chemical mechanical polishing pad and the substrate; and dispensing the chemical mechanical polishing composition onto the chemical mechanical polishing pad at or near the interface between the chemical mechanical polishing pad and the substrate; wherein the chemical mechanical polishing composition has a pH of 2 to 6; wherein the chemical mechanical polishing composition exhibits a silicon dioxide removal rate of at least 1,500 Å/min. | 11-04-2010 |
Zhijing Liu, Audubon, PA US
Patent application number | Description | Published |
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20080306897 | System for Providing Healthcare Operation Specific User Interface Display Images - A system provides a user interface for viewing nursing problems with multiple levels of granularity in a knowledge base and rendered in an application that are dependent on context of problems, patient demographic information and information needed by a user interface image. A user interface system presents patient medical problem information to a user. The system includes a first search processor for automatically searching a knowledge base of information associating multiple different medical problems with corresponding attributes to find an attribute indicating a particular characteristic of a particular medical problem, in response to occurrence of an event. A display processor initiates generation of data representing a display image. The display image includes, a first image area for including data indicating candidate medical problems and associated attributes and a second image area for including data representing assigned medical problems of a particular patient and enabling a user to select a medical problem for transfer from the first image area to the second image area. | 12-11-2008 |
Zhi (lewis) Liu, Paoli, PA US
Patent application number | Description | Published |
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20100293806 | SYSTEMS AND METHODS FOR DRYING A ROTATING SUBSTRATE - A system of drying a surface of a substrate is provided. The system includes a rotary support for supporting a substrate; and an assembly comprising a first dispenser, a second dispenser, and a third dispenser, the assembly positioned above the surface of the substrate, the second and third dispensers positioned on the assembly adjacent to and in contact with one another and spaced from the first dispenser, the second dispenser having an opening that is larger than an opening of the third dispenser, and the second dispenser being located between the first and third dispensers; and means for translating the assembly generally parallel to the surface of the substrate. | 11-25-2010 |
20120061806 | SYSTEMS AND METHODS FOR DRYING A ROTATING SUBSTRATE - A method of drying a surface of a substrate is provided. The method includes supporting a substrate; rotating the substrate about a rotational center point; applying a liquid to the substrate via a liquid dispenser; applying a drying fluid to the substrate via a drying fluid dispenser; moving the drying fluid dispenser and the liquid dispenser in a direction toward an edge region of the substrate, the drying fluid being applied closer to the rotational center point than the fluid; upon the liquid being applied to the edge region of the substrate, discontinuing application of the liquid while continuing the manipulation of the drying fluid dispenser; and upon the drying fluid being applied to the edge region of the substrate, continuing to apply the drying fluid for a predetermined period of time. | 03-15-2012 |
20130167393 | SYSTEMS AND METHODS FOR DRYING A ROTATING SUBSTRATE - A system for drying a surface of a substrate is provided. The system for drying a surface of a substrate comprising: a rotary support; a first dispenser fluidly coupled to a source of liquid, the first dispenser positioned above the surface of the substrate so as to be capable of applying a film of the liquid to the surface of the substrate; a second dispenser fluidly coupled to a source of drying fluid with a supply line, the second dispenser positioned above the surface of the substrate so as to be capable of applying the drying fluid to the surface of the substrate; and a proportional valve operably coupled to the supply line between the second dispenser and the source of drying fluid, the proportional valve capable of being incrementally adjusted from a closed position to an open position. | 07-04-2013 |
20140283884 | SYSTEMS AND METHODS FOR DRYING A ROTATING SUBSTRATE - A system for drying a surface of a substrate is provided. The system for drying a surface of a substrate comprising: a rotary support; a first dispenser fluidly coupled to a source of liquid, the first dispenser positioned above the surface of the substrate so as to be capable of applying a film of the liquid to the surface of the substrate; a second dispenser fluidly coupled to a source of drying fluid with a supply line, the second dispenser positioned above the surface of the substrate so as to be capable of applying the drying fluid to the surface of the substrate; and a proportional valve operably coupled to the supply line between the second dispenser and the source of drying fluid, the proportional valve capable of being incrementally adjusted from a closed position to an open position. | 09-25-2014 |
Zhiwen Liu, State College, PA US
Patent application number | Description | Published |
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20100309465 | COHERENT ANTI-STOKES RAMAN HOLOGRAPHY - Apparatus and methods of four wave mixing (FWM) holography are described, including illuminating a sample with a first beam, a second beam, and a third beam, and combining the generated FWM signal with a reference beam at a imaging device to obtain holographic image data. In some examples, the first and second beams may be provided by a single pump-probe beam. The third beam may be a Stokes beam or an anti-Stokes beam. A representative example is coherent anti-Stokes Raman holography (CARS holography), which includes illuminating a sample with a pump/probe beam and a Stokes beam to obtain a CARS signal from the sample; and combining the CARS signal with a reference beam to obtain a CARS hologram. | 12-09-2010 |
20120038918 | Compact Spectrometer Including a Diffractive Optical Element with Dual Dispersion and Focusing Functionality - Embodiments of the invention provide a device called a “G-Fresnel” device that performs the functions of both a linear grating and a Fresnel lens. We have fabricated the G-Fresnel device by using PDMS based soft lithography. Three-dimensional surface profilometry has been performed to examine the device quality. We have also conducted optical characterizations to confirm its dual focusing and dispersing properties. The G-Fresnel device can be useful for the development of miniature optical spectrometers as well as emerging optofluidic applications. Embodiments of compact spectrometers using diffractive optical elements are also provided. Theoretical simulation shows that a spectral resolution of approximately 1 nm can be potentially achieved with a millimeter-sized G-Fresnel. A proof-of-concept G-Fresnel-based spectrometer with subnanometer spectral resolution is experimentally demonstrated. | 02-16-2012 |
20140146159 | Z-MICROSCOPY - We present a method for parallel axial imaging, or z-microscopy, utilizing an array of tilted micro mirrors arranged along the axial direction. Image signals emitted from different axial positions can be orthogonally reflected by the corresponding micro mirrors and spatially separated for parallel detection, essentially converting the more challenging axial imaging to a lateral imaging problem. Each micro mirror also provides optical sectioning capability due to its finite dimension. | 05-29-2014 |
Zhong-Min Liu, Doylestown, PA US
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20080232008 | Electrostatic discharge safe under conveyor antenna - An antenna for use in a conveyor system in which items on which radio frequency identification tags are disposed are moved on a conveyor along a path of travel, includes a ground plane, a substrate having a bottom surface received adjacent the ground plane, at least one patch element disposed on a top surface of the substrate, a cover received adjacent the top surface of the substrate, and a front static conductive strip disposed along a front edge of the cover. The antenna is disposed beneath the conveyor and a front edge of the antenna is transverse to the path of travel. The front static conductive strip is electrically connected to the ground plane such that an electrostatic discharge event adjacent the front static conductive strip is discharged to the ground plane. | 09-25-2008 |
20100277319 | RADIO FREQUENCY IDENTIFICATION TAG IDENTIFICATION SYSTEM - A conveyor system for processing items on which radio frequency identification tags are disposed has a conveyor that conveys items through a path of travel, and an antenna disposed proximate the path of travel. Circuitry in communication with the antenna may associate RFID tag data with a package on the conveyor based on a difference signal from elements in the antenna. | 11-04-2010 |
Zhu Liu, Pittsburgh, PA US
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20110045557 | Novel Fusion Carbonic Anhydrase/Cellulose Binding Polypeptide Encoded by a Novel Hybrid Gene, and Method of Creating and Using the Same - The invention relates a novel hybrid carbonic anhydrase catalyst with the potential to contribute significantly to meeting targeted reductions in greenhouse gas emissions. In a preferred embodiment of the present invention at least a portion of a cellulose binding domain (CBD) of a protein is fused to another protein, carbonic anhydrase, (CA) to create a new multi-functional protein which can bind tightly to cellulose while maintaining its native catalytic ability to process CO | 02-24-2011 |
20120009657 | NOVEL FUSION CARBONIC ANHYDRASE/CELLULOSE BINDING POLYPEPTIDE ENCODED BY A NOVEL HYBRID GENE, AND METHOD OF CREATING AND USING THE SAME - The invention relates a novel hybrid carbonic anhydrase catalyst with the potential to contribute significantly to meeting targeted reductions in greenhouse gas emissions. In a preferred embodiment of the present invention at least a portion of a cellulose binding domain (CBD) of a protein is fused to another protein, carbonic anhydrase, (CA) to create a new multifunctional protein which can bind tightly to cellulose while maintaining its native catalytic ability to process CO | 01-12-2012 |