Patent application number | Description | Published |
20100148056 | Mass Spectrometer - A mass spectrometer is disclosed comprising an orthogonal acceleration Time of Flight mass analyser. A pulse or packet of ions is released either from an ion trap ( | 06-17-2010 |
20100252730 | Mass Spectrometer - A mass spectrometer is disclosed comprising a quadrupole rod set ion trap ( | 10-07-2010 |
20110049358 | Linear Ion Trap - A linear ion trap ( | 03-03-2011 |
20110180704 | Mass Spectrometer - An ion guide or mass analyser is disclosed comprising a plurality of electrodes having apertures through which ions are transmitted in use. A pseudo-potential barrier is created at the exit of the ion guide or mass analyser. The amplitude or depth of the pseudo-potential barrier is inversely proportional to the mass to charge ratio of an ion. One or more transient DC voltages are applied to the electrodes of the ion guide or mass analyser in order to urge ions along the length of the ion guides or mass analyser. The amplitude of the transient DC voltage applied to the electrode may be increased with time so that ions are caused to be emitted from the ion guide or mass analyser in reverse order of their mass to charge ratio. | 07-28-2011 |
20120032074 | Mass Spectrometer Arranged To Perform MS/MS/MS - A mass spectrometer is disclosed comprising an ion trap and a fragmentation device. Ions are fragmented in the ion trap to form first generation fragment ions. The ion trap has a relatively high mass cut-off. The first generation fragment ions are then transferred to a fragmentation device which is arranged to have a substantially lower low mass cut-off. The first generation fragment ions are fragmented within the fragmentation device any may optionally be stored in an ion accumulation region prior to being passed to a mass analyser for subsequent mass analysis. | 02-09-2012 |
20120119078 | Ion Population Control Device For A Mass Spectrometer - A mass spectrometer is disclosed wherein an ion beam attenuator is arranged upstream of an ion trap mass analyser. An ion tunnel ion trap comprising an upstream ion accumulation section and a downstream ion accumulation section is arranged upstream of the ion beam attenuator. Ions are released from the ion tunnel ion trap and the intensity of the ion beam which is transmitted to the ion trap analyser is controlled by the ion beam attenuator. The fill time during which ions are admitted into the ion trap mass analyser remains substantially constant and is substantially independent of the intensity of the ion beam. | 05-17-2012 |
20120122077 | Method to Detect and Sequence Post Translationally Modified Peptides - A method of detecting and sequencing post translationally modified peptides is disclosed wherein a negative ion precursor scan is performed. A negative ion high resolution MS scan is then performed and then MRM channels in positive ion mode are determined and monitored. A positive ion MS/MS scan is then performed. | 05-17-2012 |
20120280123 | Ion Tunnel Ion Guide - An ion guide is disclosed comprising a plurality of axial groupings of electrodes, wherein each axial grouping of electrodes comprises a ring or annular electrode which has been radially segmented into a plurality of electrode segments. | 11-08-2012 |
20130099110 | Mass to Charge Ratio Selective Ejection from Ion Guide Having Supplemental RF Voltage Applied Thereto - An ion guide is disclosed wherein an axial DC voltage barrier is created at the exit of the ion guide. A primary RF voltage is applied to the electrodes in order to confine ions radially within the ion guide. A supplemental RF voltage is also applied to the electrodes. The supplemental RF voltage has a greater axial repeat length than that of the primary RF voltage. The amplitude of the supplemental RF voltage is increased with time causing ions to become unstable and gain sufficient axial kinetic energy such that the ions overcome the axial DC voltage barrier. Ions emerge axially from the ion guide in mass to charge ratio order. | 04-25-2013 |
20130221242 | Mass Spectrometer - A mass spectrometer is disclosed comprising a quadrupole rod set ion trap wherein a potential field is created at the exit of the ion trap which decreases with increasing radius in one radial direction. Ions within the ion trap are mass selectively excited in a radial direction. Ions which have been excited in the radial direction experience a potential field which no longer confines the ions axially within the ion trap but which instead acts to extract the ions and hence causes the ions to be ejected axially from the ion trap. | 08-29-2013 |
20130248704 | Mass Spectrometer Arranged to Perform MS/MS/MS - A mass spectrometer is disclosed comprising an ion trap and a fragmentation device. Ions are fragmented in the ion trap to form first generation fragment ions. The ion trap has a relatively high mass cut-off. The first generation fragment ions are then transferred to a fragmentation device which is arranged to have a substantially lower low mass cut-off. The first generation fragment ions are fragmented within the fragmentation device any may optionally be stored in an ion accumulation region prior to being passed to a mass analyser for subsequent mass analysis. | 09-26-2013 |
20130267037 | MASS SPECTROMETER DEVICE AND METHOD USING SCANNED PHASE APPLIED POTENTIALS IN ION GUIDANCE - An ion guide or mass analyser is disclosed comprising a plurality of electrodes having apertures through which ions are transmitted in use. A pseudo-potential barrier is created at the exit of the ion guide or mass analyser. The amplitude or depth of the pseudo-potential barrier is inversely proportional to the mass to charge ratio of an ion. One or more transient DC voltages are applied to the electrodes of the ion guide or mass analyser in order to urge ions along the length of the ion guides or mass analyser. The amplitude of the transient DC voltage applied to the electrode may be increased with time so that ions are caused to be emitted from the ion guide or mass analyser in reverse order of their mass to charge ratio. | 10-10-2013 |
20130334413 | Fast Pushing Time of Flight Mass Spectrometer Combined With Restricted Mass to Charge Ratio Range Delivery - Ions having a restricted range of mass to charge ratios are transmitted to the acceleration region of a Time of Flight mass analyser. A control system applies a first extraction pulse to an acceleration electrode in order to accelerate a first group of ions into the time of flight region at a first time T | 12-19-2013 |
20140048695 | Curved Ion Guide With Non Mass To Charge Ratio Dependent Confinement - A non-linear ion guide is disclosed comprising a plurality of electrodes. An ion guiding region is arranged between the electrodes, and the ion guiding region curves at least in a first direction. A DC voltage is applied to at least some of the electrodes in order to form a DC potential well which acts to confine ions within the ion guiding region in the first direction. | 02-20-2014 |
20140048696 | DC Ion Guide for Analytical Filtering/Separation - An ion guide is disclosed comprising a plurality of electrodes. A first device is arranged and adapted to apply a RF voltage to at least some of the electrodes in order to form, in use, a pseudo-potential well which acts to confine ions in a first direction within the ion guide. A second device is arranged and adapted to apply a DC voltage to at least some of the electrodes in order to form, in use, a DC potential well which acts to confine ions in a second direction within the ion guide. A third device is arranged and adapted to cause ions having desired or undesired mass to charge ratios to be mass to charge ratio selectively ejected from the ion guide in the second direction. | 02-20-2014 |
20140117219 | Dynamic Resolution Correction of Quadrupole Mass Analyser - A method of mass spectrometry is disclosed comprising automatically correcting the mass or mass to charge ratio resolution of a quadrupole mass filter or mass analyser one or more times during an experimental run or acquisition based upon a measurement, determination or estimation of the mass or mass to charge ratio resolution of one or more reference ions observed in a mass spectrum or mass spectral data acquired either during the same experimental run or acquisition or during a previous experimental run or acquisition. | 05-01-2014 |
20140131566 | Mass Spectrometer - A collision or fragmentation cell is disclosed comprising a plurality of electrodes wherein a first RF voltage is applied to an upstream group of electrodes and a second different RF voltage is applied to a downstream group of electrodes. The radial confinement of parent ions entering the collision or fragmentation cell is optimised by the first RF voltage applied to the upstream group of electrodes and the radial confinement of daughter or fragment ions produced within the collision or fragmentation cell is optimised by the second different RF voltage applied to the downstream group of electrodes. | 05-15-2014 |
20140131568 | Mass Spectrometer - A mass spectrometer is disclosed comprising a quadrupole rod set ion trap wherein a potential field is created at the exit of the ion trap which decreases with increasing radius in one radial direction. Ions within the on trap are mass selectively excited in a radial direction. Ions which have been excited in the radial direction experience a potential field which no longer confines the ions axially within the ion trap but which instead acts to extract the ions and hence causes the ions to be ejected axially from the ion trap. | 05-15-2014 |
20140138534 | Mass Spectrometer Device and Method Using Scanned Phase Applied Potentials in Ion Guidance - An ion guide or mass analyser is disclosed comprising a plurality of electrodes having apertures through which ions are transmitted in use. A pseudo-potential barrier is created at the exit of the ion guide or mass analyser. The amplitude or depth of the pseudo-potential barrier is inversely proportional to the mass to charge ratio of an ion. One or more transient DC voltages are applied to the electrodes of the ion guide or mass analyser in order to urge ions along the length of the ion guides or mass analyser. The amplitude of the transient DC voltage applied to the electrode may be increased with time so that ions are caused to be emitted from the ion guide or mass analyser in reverse order of their mass to charge ratio. | 05-22-2014 |
20140166895 | Ion Tunnel Ion Guide - An ion guide is disclosed comprising a plurality of axial groupings of electrodes, wherein each axial grouping of electrodes comprises a ring or annular electrode which has been radially segmented into a plurality of electrode segments. | 06-19-2014 |
20140191123 | Ion Guide Coupled to MALDI Ion Source - A pulsed ion source is disclosed wherein the ion source is energised one or more times to generate a first group of ions and a second group of ions. The first and second groups of ions are simultaneously transmitted through an ion guide whilst keeping the first and second groups of ions isolated from each other. | 07-10-2014 |
20140217279 | Aperture Gas Flow Restriction - A mass spectrometer is disclosed comprising two vacuum chambers maintained at different pressures. The two vacuum chambers are interconnected by a differential pumping aperture. The effective area of the opening between the two vacuum chambers may be varied by rotating a disk having an aperture in front of the differential pumping aperture so as to vary the gas flow rate through the opening and between the two chambers. | 08-07-2014 |
20140284469 | Performance Improvements for RF-Only Quadrupole Mass Filters and Linear Quadrupole Ion Traps With Axial Ejection - A RF only quadrupole rod set mass filter or mass analyser and a linear quadrupole ion trap with axial ejection are disclosed comprising a first pair of rod electrodes, a second pair of rod electrodes and an energy filter. The first pair of rod electrodes is longer than the second pair of rod electrodes. Ions having desired mass to charge ratios experience fringing fields at an exit region which results in the ions possessing sufficient axial kinetic energy to be transmitted by the energy filter. Other ions possess insufficient axial kinetic energy to be transmitted by the energy filter and are attenuated. | 09-25-2014 |
20140291501 | Photo-Dissociation of Proteins and Peptides in a Mass Spectrometer - A method of mass spectrometry is disclosed comprising directing first photons from a laser onto ions located within a 2D or linear ion guide or ion trap. The frequency of the first photons is scanned and first photons and/or second photons emitted by the ions are detected. The ions are then mass analysed using a Time of Flight mass analyser. | 10-02-2014 |
20140299761 | Ion Trap With Spatially Extended Ion Trapping Region - A mass or mass to charge ratio selective ion trap is disclosed having an increased charge storage capacity. A RF voltage acts to confine ions in a first (y) direction within the ion trap. A DC voltage and/or an RF voltage acts to confine ions in a second (x) direction within the ion trap. A quadratic DC potential well acts to confine ions in a third (z) direction within the ion trap. Ions are excited in the third (z) direction and are caused to be mass or mass to charge ratio selectively ejected in the third (z) direction. | 10-09-2014 |
20140306103 | Ion Inlet For A Mass Spectrometer - An ion inlet for a mass spectrometer is disclosed comprising a housing having a sampling orifice and an atmospheric pressure orifice. One or more gas outlets are provided in the housing. Gas is drawn through the sampling orifice by a pump so that the gas exits via the one or more gas outlets. | 10-16-2014 |
20140332683 | Mass Spectrometer Arranged to Perform MS/MS/MS - A mass spectrometer is disclosed comprising an on trap and a fragmentation device. Ions are fragmented in the on trap to form first generation fragment ions. The ion trap has a relatively high mass cut-off. The first generation fragment ions are then transferred to a fragmentation device which is arranged to have a substantially lower low mass cut-off. The first generation fragment ions are fragmented within the fragmentation device any may optionally be stored in an ion accumulation region prior to being passed to a mass analyser for subsequent mass analysis. | 11-13-2014 |
20150034814 | MALDI Imaging and Ion Source - An ion source for a mass spectrometer is disclosed comprising a lens and mirror arrangement which focuses a laser beam onto the upper surface of a target substrate. The lens has an effective focal length ≦300 mm. The laser beam is directed onto the target substrate at an angle θ with respect to the perpendicular to the target substrate, wherein θ≦3°. One or more ion guides receive ions released from the target substrate and onwardly transmit the ions along an ion path which substantially bypasses the lens and mirror. | 02-05-2015 |
20150060655 | Ion Guide Construction Method - A method of constructing an ion guide is disclosed comprising providing an elongated spine member and a plurality of plates. Each plate comprises an aperture therethrough for receiving the spine member and at least one electrode for use in guiding ions. The apertures of the plates are arranged around the spine member and the plates are arranged along the spine member. The plates are then locked in position on the spine member such that the plates are fixed axially with respect to the spine member and so that the electrodes of the plates are arranged so as to form an array of electrodes for use in guiding ions. | 03-05-2015 |
20150060658 | Performance Improvements for RF-Only Quadrupole Mass Filters and Linear Quadrupole Ion Traps With Axial Ejection - A RF only quadrupole rod set mass filter or mass analyser and a linear quadrupole ion trap with axial ejection are disclosed comprising a first pair of rod electrodes, a second pair of rod electrodes and an energy filter. The first pair of rod electrodes is longer than the second pair of rod electrodes. Ions having desired mass to charge ratios experience fringing fields at an exit region which results in the ions possessing sufficient axial kinetic energy to be transmitted by the energy filter. Other ions possess insufficient axial kinetic energy to be transmitted by the energy filter and are attenuated. | 03-05-2015 |
20150090876 | Method to Detect and Sequence Post Translationally Modified Peptides - A method of detecting and sequencing post translationally modified peptides is disclosed wherein a negative ion precursor scan is performed. A negative ion high resolution MS scan is then performed and then MRM channels in positive ion mode are determined and monitored. A positive ion MS/MS scan is then performed. | 04-02-2015 |
20150287584 | Fast Pushing Time of Flight Mass Spectrometer Combined With Restricted Mass to Charge Ratio Range Delivery - Ions having a restricted range of mass to charge ratios are transmitted to the acceleration region of a Time of Flight mass analyser. A control system applies a first extraction pulse to an acceleration electrode in order to accelerate a first group of ions into the time of flight region at a first time T | 10-08-2015 |
20150294850 | Ion Trap With Spatially Extended Ion Trapping Region - A mass or mass to charge ratio selective ion trap is disclosed which directs ions into a small ejection region. A RF voltage acts to confine ions in a first (y) direction within the ion trap. A DC or RF voltage acts to confine ions in a second (x) direction. A quadratic DC potential well acts to confine ions in a third (z) direction within the ion trap. The profile of the quadratic DC potential well progressively varies along the second (x) direction. | 10-15-2015 |