Patent application number | Description | Published |
20130027029 | SYSTEM AND METHOD FOR INSPECTING A SUBSEA PIPELINE - The present invention is directed to a system and a method for inspecting a subsea pipeline. The method comprises the steps: detecting a defect along the subsea pipeline using a subsea magnetometric tomography method (MTM) module adjacent the subsea pipeline; and determining a position of the subsea MTM module, thereby determining the position of the defect. The method further comprises determining the position of the subsea MTM module relative to a surface vessel; and determining an absolute position of the surface vessel. | 01-31-2013 |
20140368191 | APPARATUS AND METHOD FOR METALLIC CONSTRUCTIONS ASSESSMENT - A device for discovering, identification and monitoring, of mechanical flaws in metallic structures is disclosed, based on magneto-graphic/magnetic tomography technique to identify stress-related defects. The device includes registration means that optimized for use with metallic structures of various types, shapes and sizes. Applications include a real-time quality control, monitoring and emergency alarms, as well structural repairs and maintenance work recommendations and planning. Examples of the device implementation include pipes for oil and gas industry monitoring, detection of flaws in rolled products in metallurgical industry, welding quality of heavy duty equipment such as ships, reservoirs. etc. It is especially important for loaded constructions, such as pressured pipes, infrastructure maintenance, nuclear power plant monitoring, bridges, corrosion prevention and environment protection. | 12-18-2014 |
Patent application number | Description | Published |
20090028889 | Novel Polypeptide Ligands For Toll-Like Receptor 2 (TLR2) - The present invention provides novel polypeptide ligands for Toll-like Receptor 2 (TLR2). Preferrably, the novel polypeptide ligands modulate TLR2 signaling and thereby regulate the Innate Immune Response. The invention also provides vaccines comprising the novel polypeptide TLR2 ligands and an antigen. The invention further provides methods of modulating TLR2 signaling using the polypeptide ligands or vaccines of the invention. | 01-29-2009 |
20090068224 | METHOD TO IDENTIFY POLYPEPTIDE TOLL-LIKE RECEPTOR (TLR) LIGANDS - The present invention provides novel methods to identify polypeptide ligands for Toll-like Receptors (TLRs), such as TLR2, TLR4 and TLR5. The method involves the use of phage display technology in an iterative biopanning procedure. The invention also provides polypeptide TLR ligands identified by the methods of the invention. In preferred embodiments, the polypeptide TLR ligands so identified modulate TLR signaling and thereby regulate the Innate Immune Response. The invention also provides vaccines comprising a polypeptide TLR ligand identified by the methods of the invention and an antigen. The invention also provides methods of modulating TLR signaling using the polypeptide TLR ligands and vaccines of the invention. | 03-12-2009 |
20090162400 | Compositions of influenza viral proteins and methods of use thereof - Compositions, fusion proteins and polypeptides comprise at least one pathogen-associated molecular pattern and at least a portion of at least one integral membrane protein of an influenza viral antigen. The compositions, fusion proteins and polypeptides are used to stimulate an immune response in a subject. | 06-25-2009 |
20100303847 | COMPOSITIONS OF TOLL-LIKE RECEPTOR AGONISTS AND PAPILLOMAVIRUS ANTIGENS AND METHODS OF USE THEREOF - Compositions that include at least one protein that activates a Toll-like Receptor and includes at least a portion of at least one Toll-like Receptor agonist and at least a portion of at least one papillomavirus suppressor binding protein, papillomavirus transforming protein and papillomavirus capsid protein can be employed in methods that stimulate an immune response in a subject, in particular, a protective immune response in a subject. Compositions can further include an adjuvant and a carrier protein. | 12-02-2010 |
20110008383 | COMPOSITIONS OF TOLL-LIKE RECEPTOR AGONISTS AND MALARIA ANTIGENS AND METHODS OF USE - Compositions that include at least one fusion protein that includes at least a portion of at least one flagellin and at least a portion of at least one malaria antigen can be employed in methods that stimulate an immune response in a subject, in particular, sterile immunity and a protective immune response in a subject. | 01-13-2011 |
20110117128 | Compositions that Include Hemagglutinin, Methods of Making and Methods of Use Thereof - Compositions comprise a flagellin component that is at least a portion of a flagellin, wherein the flagellin component includes at least one cysteine residue and whereby the flagellin component activates a Toll-like Receptor 5. Compositions can further include an antigen, such as an influenza antigen. The compositions are used to stimulate an immune response and a protective immune response in a subject. | 05-19-2011 |
Patent application number | Description | Published |
20130136763 | Methods Of Treatment With Compositions That Include Hemagglutinin - Methods that stimulate a protective immune response in a subject include a portion of a protein from a naturally occurring viral hemagglutinin, wherein the protein portion includes at least a portion of a globular head and at least a portion of at least one secondary structure that causes the globular head to essentially retain its tertiary structure, and wherein the protein portion lacks a transmembrane domain, a cytoplasmic domain and an HA2 subunit. Compositions administered to the subject can further include a carrier and can be administered in single or multiple doses. | 05-30-2013 |
20130224798 | Methods of Making Hemagglutinin Proteins - Methods of making a protein that stimulates a protective immune response in a subject include separating a portion of a protein from a naturally occurring influenza viral hemagglutinin to form a protein portion. The protein portion includes at least a portion of a globular head, and at least a portion of at least one secondary structure having at least one β-sheet at a bottom of the globular head that causes the globular head to essentially retain its tertiary structure. The protein portion made by the methods of the invention lacks a transmembrane domain, a cytoplasmic domain and an HA2 subunit. A nucleic acid sequence encoding the protein portion is transformed into a prokaryotic host cell. | 08-29-2013 |
20130331548 | COMPOSITIONS OF FLAGELLIN AND PAPILLOMAVIRUS ANTIGENS - Compositions that include at least one protein that activates a Toll-like Receptor and includes at least a portion of at least one Toll-like Receptor agonist and at least a portion of at least one papillomavirus suppressor binding protein, papillomavirus transforming protein and papillomavirus capsid protein can be employed in methods that stimulate an immune response in a subject, in particular, a protective immune response in a subject. Compositions can further include an adjuvant and a carrier protein. | 12-12-2013 |
20140037683 | Methods of Stimulating Protective Immunity Employing Dengue Viral Antigens - Compositions that include at least a portion of at least one pathogen-associated molecular pattern and at least a portion of at least one member selected from the group consisting of a Den1 viral envelope protein, a Den2 viral envelope protein, a Den3 viral envelope protein and a Den4 viral envelope protein are employed in methods to stimulate a protective immune response in a subject. | 02-06-2014 |
20150031858 | Methods of Stimulating Protective Immunity Employing Dengue Viral Antigens - Compositions that include at least a portion of at least one pathogen-associated molecular pattern and at least a portion of at least one member selected from the group consisting of a Den1 viral envelope protein, a Den2 viral envelope protein, a Den3 viral envelope protein and a Den4 viral envelope protein are employed in methods to stimulate a protective immune response in a subject. | 01-29-2015 |