Pilar
Pilar Alcalde Aguilar, Sant Joan Despi ES
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20120289553 | ORAL LIQUID PHARMACEUTICAL COMPOSITION OF NIFEDIPINE - It relates to an oral liquid pharmaceutical composition comprising: a) nifedipine in an amount comprised between 0.1% and 1% w/w; b) ethanol in an amount comprised between 38% and 58% w/w; c) water in an amount comprised between 4% and 12% w/w; d) glycerine in an amount comprised between 30% and 50% w/w; and e) optionally, other pharmaceutical excipients or carriers, the sum total of components being 100% w/w, provided that the composition is substantially free of polyethyleneglycol and derivatives thereof. | 11-15-2012 |
Pilar Arias Crespo, Santiago De Compostela DE
Pilar Ayarza, North Bergen, NJ US
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20090248073 | BABY TEETHING DEVICES HAVING TEETHING RIDGES - A baby teething device is provided that includes a shield, a handle depending from the shield, a nipple-like portion depending from the shield opposite the handle, and teething ridges defined on the nipple-like portion. The teething ridges can include a series of generally linear ridges that are substantially parallel to the shield and/or a plurality of concentric teething ridges. | 10-01-2009 |
Pilar Balerdi Azpilicueta, Barindano ES
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20090320312 | DRYER COMPRISING A HEAT SINK AND A CONDENSATE CONTAINER - A dryer includes a drying chamber, a process air guide that guides process air along the articles to pick up humidity from them, a heat sink in the process air guide that precipitates humidity from the process air as a condensate, and a condensate collector with a condensate container having an insert that is permeable to the condensate and that projects through an opening into the condensate container for transferring the condensate to and from the condensate container. The insert includes a first filter that filters particles from the condensate prior to storing the condensate in the condensate container. | 12-31-2009 |
Pilar Balerdi Azpilicueta, Barindano (navarra) ES
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20100242297 | HOUSEHOLD APPLIANCE HAVING A HEAT PUMP UNIT AND MEANS FOR COOLING A COMPONENT THEREOF - A household appliance includes a housing, a controller within the housing, a drying chamber within the housing, a closed-loop process air channel within the housing and including, a first blower operable by the controller, a heat pump operable by the controller, a condensate collector that collects condensate from the heat pump, and means for cooling a component of the heat pump including an open-loop cooling channel with a second blower operable by the controller. The appliance further includes a temperature sensor within the housing operable by the controller to generate a signal dependent upon a temperature within the housing, and wherein the controller operates the second blower in response to the signal. | 09-30-2010 |
20100263225 | HOUSEHOLD APPLIANCE COMPRISING A FIRST AIR CONDUIT AND A HEAT PUMP - A household appliance including a housing; a drying chamber to dry wet articles in the drying chamber; and a first air conduit to guide process air drawn into the housing to dry the wet articles. The household appliance also has a heat pump that includes a heat sink to transfer heat into the heat pump; a heat source coupled to the first air conduit to transfer the heat from the heat pump into the process air; and a heat transfer device to transfer the heat from the heat sink to the heat source. A second air conduit is coupled to the heat sink to guide secondary air drawn into the housing. The heat sink transfers the heat from the secondary air into the heat pump. | 10-21-2010 |
20100263226 | WASHING/DRYING DEVICE COMPRISING A MOISTURE DETERMINING DEVICE AND METHOD FOR OPERATING A WASHING/DRYING DEVICE - A laundry drying device having a washing drum; a moisture determining device to determine a moisture content of process air evacuated from the washing drum, wherein the moisture determining device has at least one temperature sensor; and a cooling body to cool the process air, wherein the cooling body has an inlet side, an outlet side, and an inlet for a medium that flows through the cooling body or that is located in the cooling body. A first temperature sensor is arranged behind the inlet of the cooling body; a second temperature sensor is arranged at the outlet side of the cooling body to measure an outlet temperature of the medium; and a third temperature sensor is arranged at the inlet side of the cooling body to measure an inlet temperature of the medium. The medium is the process air or a coolant. | 10-21-2010 |
20100275457 | HOUSEHOLD APPLIANCE WITH A HEAT PUMP - The invention relates to a household appliance | 11-04-2010 |
Pilar Bañados, Huechuraba CL
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20130047306 | Raspberry plant named 'PACIFIC MAJESTY' - A new and distinct cultivar of Raspberry plant named ‘Pacific Majesty’ as described and shown herein. ‘Pacific Majesty’ provides typically larger fruit, better firmness and typically higher yields than ‘Rafzaqu’, U.S. Plant Pat. No. 19,512 and ‘Marcela’ U.S. Plant Pat. No. 17,819. ‘Pacific Majesty’ provides fruit with a lighter red color than ‘Pacific Royale’ U.S. Plant Pat. No. 21,536. Distinct characteristics of ‘Pacific Majesty’ include the combination of very large, conic fruit, bright color and high yield. | 02-21-2013 |
Pilar Bañados, Huechuraba CL
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20130047306 | Raspberry plant named 'PACIFIC MAJESTY' - A new and distinct cultivar of Raspberry plant named ‘Pacific Majesty’ as described and shown herein. ‘Pacific Majesty’ provides typically larger fruit, better firmness and typically higher yields than ‘Rafzaqu’, U.S. Plant Pat. No. 19,512 and ‘Marcela’ U.S. Plant Pat. No. 17,819. ‘Pacific Majesty’ provides fruit with a lighter red color than ‘Pacific Royale’ U.S. Plant Pat. No. 21,536. Distinct characteristics of ‘Pacific Majesty’ include the combination of very large, conic fruit, bright color and high yield. | 02-21-2013 |
Pilar Blancafort, East Fremantle AU
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20160108100 | Interference Peptides and Use Thereof - A purified and isolated peptide comprises an amino acid sequence of SEQ ID NOs: 1 to 8. A method is also provided for preventing interaction, e.g. binding, of EN1 with EPRS in a cell by introducing, into the cell, a peptide having a sequence of SEQ ID NOs: 1 to 8, which results in the peptide interacting with EPRS thereby preventing an interaction of EPRS with EN1. Apoptosis can be induced in a cell expressing either or both of EN1 and EN2, by introducing into the cell, a peptide of SEQ ID NOs: 1 to 8. | 04-21-2016 |
Pilar Calvo Salve, Madrid ES
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20090076016 | FORMULATIONS COMPRISING JORUMYCIN-, RENIERAMYCIN-, SAFRACIN- OR SAFRAMYCIN-RELATED COMPOUNDS FOR TREATING PROLIFERATIVE DISEASES - Jorumycin, renieramycin, safracin and saframycin related compounds formulations, methods of preparing the same, articles of manufacture and kits with such formulations, and methods of treating proliferative diseases with the same formulations are provided. | 03-19-2009 |
20150094313 | PHARMACEUTICAL FORMULATIONS OF ECTEINASCIDIN COMPOUNDS - Ecteinascidin formulations, methods of preparing the same, articles of manufacture and kits with such formulations, and methods of treating proliferative diseases with the same formulations are provided. | 04-02-2015 |
Pilar Castán Barberán, Barbera Del Valles - Barcelona ES
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20150118328 | COMPOSITION FOR SKIN HYGIENE AND/OR HYDRATION - The present invention relates to a composition for cleansing and/or moisturizing skin. The compositions of the invention which provide a cosmetic or dermatological composition for cleansing and/or moisturizing skin, preferably compositions used for showering or bathing, comprise: | 04-30-2015 |
Pilar Castán Barberán, Barcelona ES
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20120005843 | MIXTURE OF AMIDES AND COSMETIC COMPOSITIONS COMPRISING SAID MIXTURE - A mixture of amides of the following formula (I) is disclosed wherein R | 01-12-2012 |
Pilar Cidad Velasco, Valladolid ES
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20110275571 | KV1.3 CHANNEL BLOCKING SUBSTANCES FOR THE TREATMENT OF DISEASES ASSOCIATED WITH INTIMAL HYPERPLASIA - The present invention provides a therapeutic tool against intimal hyperplasia consisting of the use of Kv1.3 channel blocking substances, able to selectively stop cell migration and multiplication of VSMCs. | 11-10-2011 |
Pilar Cubas Domínguez, Madrid ES
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20120017337 | GENES REGULATING PLANT BRANCHING, PROMOTORS, GENETIC CONSTRUCTS CONTAINING SAME AND USES THEREOF - The invention relates to genes coding for TCP family transcription factors and having a biological role in the development of axillary buds and branch growth. Furthermore, the invention relates to the promoters of the transcription of said genes, to the genetic constructs containing same and to the uses thereof, including the use of agents that modulate the expression of these genes in order to modify plant architecture. | 01-19-2012 |
Pilar De Frutos Escrig, Madrid ES
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20080299034 | PROCESS FOR PREPARING HYDROGEN PEROXIDE - The present invention relates to a process for preparing hydrogen peroxide by reacting hydrogen and oxygen in the presence of a solvent and of a catalyst, wherein the catalyst comprises at least one noble or semi-noble metal supported on an inorganic material functionalized with acid groups. The invention also refers to the catalyst used in this process. | 12-04-2008 |
Pilar De La Puente, St. Louis, MO US
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20160136327 | 3D TISSUE-ENGINEERED BONE MARROW FOR PERSONALIZED THERAPY AND DRUG DEVELOPMENT - A tissue-engineered bone marrow for personalized therapy of a patient is described. The tissue-engineered bone marrow includes an autologous fibrin scaffold and a plurality of patient-derived cells isolated from the patient's bone marrow. The autologous fibrin scaffold is made using fibrinogen isolated from the patient's bone marrow. The plurality of patient-derived cells may include cells associated with a hematological or metastatic malignancy, bone marrow stromal cells, and endothelial cells. The patient-derived cells are cultured on the autologous fibrin scaffold to create the tissue-engineered bone marrow. The tissue-engineered bone marrow may be used for personalized drug screening. | 05-19-2016 |
Pilar Erra, Barcelone ES
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20100107962 | STERILISATION INDICATOR - The invention provides a sterilization indicator ( | 05-06-2010 |
20130171688 | STERILISATION INDICATOR - A sterilization indicator having a compound that is of the heating type when put into contact with atoms of oxygen O and/or nitrogen N; and a thermochromic dye, in thermal contact with the compound. | 07-04-2013 |
Pilar Estella, Zaragoza ES
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20160118181 | Transformers - A transformer may comprise a winding wrapped around a magnetic core, the winding having at least one winding portion extending between the magnetic core and the exterior of the winding in radial direction. The winding may comprise at least a first conductor and at least a second conductor, arranged radially adjacent to each other in each winding portion with the interposition of an insulating layer, wherein the first conductor is arranged radially inwardly with respect to the second conductor for part of each winding portion length, and radially outwardly with respect to the second conductor for another part of each winding portion length. | 04-28-2016 |
Pilar García Agustín, Valencia ES
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20100080860 | Application of short-chain monocarboxylic acids for crop protection - The present invention relates to the agricultural use of hexanoic acid and monocarboxylic acids with similar chain structure having from 5 to 8 carbon atoms, their derivatives, their salts, and aqueous mixtures thereof containing modified hexoses and/or amines. These compounds are useful as plant growth stimulants, anti-senescents, and as resistance inducers to biotic and abiotic stresses. The invention also refers to the use of caproic (hexanoic) acid as an inhibitor of spore germination and mycelium growth of phytopathogenic fungi. The use of hexanoic acid as a fungicide in both pre- and post-harvest treatments is also suggested. The inducing activity of hexanoic acid on plant defenses against phytopathogenic fungi at non-phytotoxic concentrations has been shown. | 04-01-2010 |
Pilar García Agustín, Valencia ES
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20100080860 | Application of short-chain monocarboxylic acids for crop protection - The present invention relates to the agricultural use of hexanoic acid and monocarboxylic acids with similar chain structure having from 5 to 8 carbon atoms, their derivatives, their salts, and aqueous mixtures thereof containing modified hexoses and/or amines. These compounds are useful as plant growth stimulants, anti-senescents, and as resistance inducers to biotic and abiotic stresses. The invention also refers to the use of caproic (hexanoic) acid as an inhibitor of spore germination and mycelium growth of phytopathogenic fungi. The use of hexanoic acid as a fungicide in both pre- and post-harvest treatments is also suggested. The inducing activity of hexanoic acid on plant defenses against phytopathogenic fungi at non-phytotoxic concentrations has been shown. | 04-01-2010 |
Pilar Garcia Pareja, Alhendin (granada) ES
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20100035984 | Use of an antibacterial compound which is derived from alliaceae, as a natural additive in animal feed - The invention relates to the use of an antibacterial compound, which is derived from alliaceae, as a natural additive in animal feed, intended as an antimicrobial agent in animal feed, and as an alternative, due to its antibacterial nature, to the use of antibiotics as growth promoters, proposing the use of the compound separately (purity greater than 95%), and encapsulated or supported on different inert materials or food coatings, and in that said compound preferably consists of propyl propylthiosulfinate and, in an alternative variant, of propyl propylthiosulfonate. | 02-11-2010 |
Pilar Garcia Suarez, Austrias ES
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20150247138 | Enhanced Staphylolytic Activity of the Staphylococcus aureus Bacteriophage vB_SauS-philPLA88 Virion-Associated Peptidoglycan Hydrolase HydH5: Fusions, Deletions and Synergy with LysH5 - Virion-associated peptidoglycan hydrolases have a potential as antimicrobial agents due to their ability to lyse Gram positive bacteria on contact. Full-length HydH5, a virion-associated peptidoglycan hydrolase from the | 09-03-2015 |
Pilar Garin-Chesa, Wien AT
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20120136004 | NEW COMBINATION THERAPY IN TREATMENT OF CANCER AND FIBROTIC DISEASES - The invention relates to new methods for the treatment of oncological and fibrotic diseases comprising the combined administration of a receptor tyrosine kinase inhibitor in conjunction with a thrombin inhibitor. | 05-31-2012 |
20120142703 | NEW COMBINATION THERAPY IN TREATMENT OF ONCOLOGICAL AND FIBROTIC DISEASES - The invention relates to new methods for the treatment of oncological and fibrotic disease comprising the combined administration of an inhibitor of vascular endothelial growth factor receptors (VEGFRs) in conjunction with a thrombin inhibitor. | 06-07-2012 |
20140066456 | COMBINATION THERAPY IN TREATMENT OF CANCER AND FIBROTIC DISEASES - The invention relates to new methods for the treatment of oncological and fibrotic diseases comprising the combined administration of a receptor tyrosine kinase inhibitor in conjunction with a thrombin inhibitor. | 03-06-2014 |
20140187563 | COMBINATION THERAPY IN TREATMENT OF ONCOLOGICAL AND FIBROTIC DISEASES - The invention relates to new methods for the treatment of oncological and fibrotic disease comprising the combined administration of an inhibitor of vascular endothelial growth factor receptors (VEGFRs) in conjunction with a thrombin inhibitor. | 07-03-2014 |
Pilar Garin-Chesa, Vienna AT
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20120244141 | Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors - A method for determining whether a cancer patient is susceptible to treatment with a protein tyrosine kinase 2 (PTK2) inhibitor, comprising detecting the expression of the E-cadherin protein in a cancer sample of said cancer patient, wherein an E-cadherin protein immunoreactivity score (IRS) of 0-2 indicates that the cancer patient is susceptible to treatment with a PTK2 inhibitor. The invention further encompasses treatment of a patient with a protein tyrosine kinase 2 (PTK2) inhibitor if it has been so determined that said patient is susceptible to such treatment. | 09-27-2012 |
20140205592 | Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors - The present invention relates to a method for determining whether a cancer patient is susceptible to treatment with a protein tyrosine kinase 2 (PTK2) inhibitor, comprising detecting the expression of the E-cadherin protein in a cancer sample of said cancer patient, wherein an E-cadherin protein immunoreactivity score (IRS) of 0-2 indicates that the cancer patient is susceptible to treatment with a PTK2 inhibitor. Said detection of the expression of the E-cadherin protein in a cancer sample of a cancer patient is preferably conducted by way of an immunohistochemistry (IHC) method. Said IHC method preferably employs a primary antibody which is specific for E-cadherin and a secondary antibody which specifically reacts with the primary antibody. The present invention also relates to a method of treating a cancer patient whose cancer is characterized by an E-cadherin protein immunoreactivity score (IRS) of 0-2, comprising administering to the patient a therapeutically effective amount of a PTK2 inhibitor. In a further aspect, the present invention relates to a PTK2 inhibitor for use in the treatment of a cancer patient whose cancer is characterized by an E-cadherin protein immunoreactivity score (IRS) of 0-2. The present invention also provides a method of screening for a therapeutically effective PTK2 inhibitor comprising the steps of (a) providing cancer cells or a cancer cell line which are characterized by an E-cadherin protein immunoreactivity score of 2, 1, or 0 (1 being preferred and 0 being even more preferred); (b) contacting the cancer cell or the cancer cell line of (a) with a PTK2 inhibitor; and (c) evaluating whether the PTK2 inhibitor negatively affects the cancer cell/cancer cell lines. In a further aspect, the present invention relates to a method for stratifying cancer patients that are susceptible to treatment with a PTK2 inhibitor, comprising determining the E-cadherin IRS score in a cancer sample of said patient, wherein an E-cadherin protein immunoreactivity score (IRS) of 0-2 (i.e. 2, 1, or 0) indicates that the cancer patient is susceptible to treatment with a PTK2 inhibitor. The present invention also relates to a pharmaceutical package comprising a PTK2 inhibitor, and (a) instructions and/or an imprint indicating that said PTK2 inhibitor is to be used for the treatment of patients which suffer from a cancer which is characterized by an E-cadherin protein immunoreactivity score of 2, 1, or 0 (1 being preferred and 0 being more preferred); and/or (b) instructions and/or an imprint indicating that said patient is to be stratified by a method of the present invention; and/or (c) means to carry out a method as defined herein. | 07-24-2014 |
Pilar Giraldo Castellano, Zaragoza ES
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20120157329 | Method and Device for the in Vitro Analysis for MRNA of Genes Involved in Haematological Neoplasias - Method and device for the in vitro analysis of mRNA of genes involved in hematological neoplasias. The device, composed of probes which specifically hybridize with genes involved in hematological neoplasias, designed so that its behaviour in the hybridization is similar, permits the evaluation of the mRNA level in biological samples taken from subjects suspected to be suffering from hematological neoplasia and facilitating the comparison between the different samples and their grouping by similarity in the gene expression patterns, especially when the probes are disposed in the form of microarray. The application of the method of the invention to obtain and process data of gene expression differences from the device of the invention permits the identification of genes significant for distinguishing samples associated to hematological neoplasias, facilitates the diagnosis of neoplasias as CLL and permits making a prognosis of the evolution thereof. | 06-21-2012 |
Pilar Gonzales-Gomes, Ansbach DE
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20150216286 | FOLDABLE APPLICATOR - A cosmetic applicator having a core that supports the application elements in the form of bristles and/or comb tines; the core has a central body that is itself equipped with a plurality of bristles and/or comb tines protruding out directly from it; the core is also composed of at least one arm that protrudes out from the central body and is itself equipped with a plurality of bristles and/or comb tines and is mobile relative to the central body. | 08-06-2015 |
Pilar Gonzalez, Leuven BE
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20140175265 | Spectral Imaging Device and Method to Calibrate the Same - A solid-state spectral imaging device is described. The device includes an image sensor and a plurality of optical filters directly processed on top of the image sensor. Each optical filter includes a first mirror and a second mirror defining an optical filter cavity having a fixed height. Each optical filter also includes a first electrode and a second electrode having a fixed position located opposite to each other and positioned to measure the height of the optical filter cavity. Further, a method to calibrate spectral data of light and a computer program for calibrating light is described. | 06-26-2014 |
Pilar Mancera Aroca, Barcelona ES
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20130039905 | Diazoxide For Use In The Treatment Or Prevention Of A Central Nervous System (CNS) Autoimmune Demyelinating Disease - The invention relates to the use of diazoxide or a pharmaceutically acceptable salt thereof at low doses to treat a CNS autoimmune demyelinating disease selected from selected from multiple sclerosis (MS), clinically isolated syndrome (CIS), tumefactive (tumor-like) M S, Marburg's acute M S, Balós's concentric sclerosis, acute disseminated encephalomyelitis (ADEM), post-vaccinal encephalitis (PVE), post-infectious encephalomyelitis (PIE) and neuromyelitis optica (NMO). | 02-14-2013 |
Pilar Mancera Aroca, Roda De Bara (tarragona) ES
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20130143873 | Diazoxide For Use In The Treatment Of Amyotrophic Lateral Sclerosis (ALS) - The invention relates to the diazoxide or a pharmaceutically acceptable salt thereof for use as a medicament at low doses to treat amyotrophic lateral sclerosis. | 06-06-2013 |
Pilar Marin Palacios, Madrid ES
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20110192643 | ELECTROMAGNETIC RADIATION ATTENUATOR AND METHOD FOR CONTROLLING THE SPECTRUM THEREOF - The invention relates to an electromagnetic radiation attenuator and a method for controlling the spectrum thereof. The attenuator of the invention is formed from an attenuating sheet located such that, in the position of use of the attenuator, said electromagnetic radiation is incident on the attenuator sheet, and from a conductive base located, in the position of use of the attenuator, beneath said attenuator sheet. The attenuator sheet is formed by two layers, the first layer, made of dielectric material and of thickness d | 08-11-2011 |
20120258245 | PAINT WITH METALLIC MICROWIRES, PROCESS FOR INTEGRATING METALLIC MICROWIRES IN PAINT AND PROCESS FOR APPLYING SAID PAINT ON METALLIC SURFACES - The present invention relates to a paint with metallic microwires, to the process for integrating metallic microwires to obtain such paint, and to a process for applying said paint on metallic surfaces ( | 10-11-2012 |
20150042502 | ELECTROMAGNETIC RADIATION ATTENUATOR - The invention relates to a material configured such as to include a plurality of layers, some layers being made of a composite material and some layers being made of a dielectric material. The layers of composite material include a mixture of host dielectric material and inclusions, such that said inclusions are embedded in the structure of the host dielectric material. Said inclusions preferably include highly conductive fibres, specifically metal microwires. Thus, the structure of the material according to the invention includes a plurality of layers, some layers being made of a composite material, which includes a host dielectric material with inclusions, and some layers being made of a dielectric material. The structure of the material according to the invention is designed so that the surface on which said material is applied is capable of absorbing a portion of the incident electromagnetic radiation, thus substantially reducing the electromagnetic radiation reflected by same curved. | 02-12-2015 |
Pilar Martinez-Martinez, Maastricht NL
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20090317382 | USE OF EFFECTOR-FUNCTION-DEFICIENT ANTIBODIES FOR TREATMENT OF AUTO-IMMUNE DISEASES - The invention relates to the treatment of autoimmune diseases and disorders, in particular myasthenia gravis, by administration of effector-function-deficient antibodies, wherein said effector-function-deficient antibodies are capable of competing with one or more of the auto-antibodies involved in mediating the antibody-mediated auto-immune disease or disorder for binding to a target auto-antigen. | 12-24-2009 |
Pilar Miranzo, Madrid ES
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20150246851 | Process For Production Of Graphene/Silicon Carbide Ceramic Composites - We provide a method for the in situ development of graphene containing silicon carbide (SiC) matrix ceramic composites, and more particularly to the in situ graphene growth within the bulk ceramic through a single-step approach during SiC ceramics densification using an electric current activated/assisted sintering (ECAS) technique. This approach allows processing dense, robust, highly electrical conducting and well dispersed nanocomposites having a percolated graphene network, eliminating the handling of potentially hazardous nanostructures. Graphene/SiC components could be used in technological applications under strong demanding conditions where good electrical, thermal, mechanical and/or tribological properties are required, such as micro and nanoelectromechanical systems (MEMS and NEMS), sensors, actuators, heat exchangers, breaks, components for engines, armours, cutting tools, microturbines or microrotors. | 09-03-2015 |
Pilar Molina Gaudó, Zaragoza ES
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20120125918 | HOTPLATE HAVING AT LEAST TWO HEATING ZONES - A hotplate apparatus, in particular for a hotplate having a cover plate having at least two heating zones, includes a cooking utensil sensor unit. The cooking utensil sensor unit has at least one bridging detection unit, which is intended to detect at least bridging of the at least two heating zones by at least one cooking utensil element. | 05-24-2012 |
Pilar Muñoz Condes, Madrid ES
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20110185941 | CONTROL SYSTEM FOR TRAIN DOORS AND ACTUATION METHOD BASED ON SAID SYSTEM - The invention relates to a control system for controlling the movement of passenger access doors in railway vehicles and method for operating them based on said system, the object of which is to reduce the number of incidents occurring in said doors and it basically comprises power control means of the motor ( | 08-04-2011 |
Pilar Munoz Fernandez, Sevilla ES
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20140107190 | HIGHLY INDUCIBLE DUAL-PROMOTER LENTIVIRAL TET-ON SYSTEM - The invention relates to expression systems useful for regulated expression of a gene of interest based on the constitutive expression of the original TetR repressor and the expression of the polynucleotide driven by a constitutive promoter operably linked to an operator sequence for a tetracycline operator sequence. The system can be provided as two different polynucleotides or as an all-in-one vector. The invention also relates to vectors, host cells and viral particles according to the invention as well as to the uses thereof for in vitro and in vivo production of products of interest or for therapy. | 04-17-2014 |
20160032318 | INSULATOR TO IMPROVE GENE TRANSFER VECTORS - The present invention solves the problem of providing more efficient barrier insulators to avoid vector silencing and to increase expression in the setting of gene transfer vectors, more particularly in the setting of gene transfer retroviral vectors. In this sense, the authors of the present invention have developed an improved insulator element, namely element IS2, which comprises the following combination of nucleic acid molecules, namely nucleic acid molecule HS4-650 bp as shown in SEQ ID No 2 and a synthetic S/MAR nucleic acid molecule containing 5 M/SARs recognition signatures (MRS) as shown in SEQ ID no 1. | 02-04-2016 |
Pilar Munoz Ruiz, Madrid ES
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20090069430 | DIBENZENE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS - The invention is directed to a compound of formula (I) | 03-12-2009 |
20100041665 | N-PHENYL-PRENYLAMINE DERIVATIVES FOR THE TREATMENT OF COGNITIVE, NEURODEGENERATIVE OR NEURONAL DISEASES OR DISORDERS - The present invention is related to a family of N-phenyl-prenylamine derivatives of formula (I), and to their use in the treatment of cognitive, neurodegenerative or neuronal diseases or disorders, such as Alzheimer's disease or Parkinson's Disease. The present invention also relates to pharmaceutical compositions comprising the same. Further, the present invention is directed to the use of the compounds in the manufacture of a medicament for the treatment and/or prevention of a cognitive, neurodegenerative or neuronal disease or disorder. | 02-18-2010 |
20100267827 | PHENYL-PRENYL-ETHER DERIVATIVES FOR THE TREATMENT OF COGNITIVE, NEURODEGENERATIVE OR NEURONAL DISEASES OR DISORDERS - The present invention is related to a family of phenyl-prenyl-ether derivatives of formula (I), and to their use in the treatment of cognitive, neurodegenerative or neuronal diseases or disorders, such as Alzheimer's disease or 5 Parkinson's Disease. The present invention also relates to pharmaceutical compositions comprising the same. Further, the present invention is directed to the use of the compounds in the manufacture of a medicament for the treatment and/or prevention of a cognitive, neurodegenerative or neuronal disease or disorder. | 10-21-2010 |
20110092591 | PHENYL-PRENYL DERIVATIVES, OF MARINE AND SYNTHETIC ORIGIN, FOR THE TREATMENT OF COGNITIVE, NEURODEGENERATIVE OR NEURONAL DISEASES OR DISORDERS - The present invention is related to a family of phenyl-prenyl derivatives of formula (I), and to their use in the treatment of cognitive, neurodegenerative or neuronal diseases or disorders, such as Alzheimer's disease or Parkinson's Disease. The present invention also relates to pharmaceutical compositions comprising the same. Further, the present invention is directed to the compounds of formula (I) for medical use, particularly for the use for the treatment and/or prevention of a cognitive, neurodegenerative or neuronal disease or disorder, and to the use of the compounds in the manufacture of a medicament for the treatment and/or prevention of a cognitive, neurodegenerative or neuronal disease or disorder. | 04-21-2011 |
20110144148 | ACETYLCHOLINESTERASE DUAL INHIBITORS - The invention provides compounds of formula: | 06-16-2011 |
Pilar Navarro Medrano, Alcobendas (madrid) ES
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20130065966 | Compound Inhibiting Activation of the Enzyme ERK 1/2 To Be Used In The Treatment Of Neurodegenerative Illnesses - The present invention relates to a compound of formula (I) for use as a medicine, in particular for use in the treatment of diseases mediated by the actvation of the protein kinase Erk1/2, such as neurogenerative illnesses like Alzheimer's and related dementia, epilepsy, Parkinson's disease, Huntington's disease, or stroke, and likewise relates to the pharmaceutical compositions containing said compound. The compound of formula (I) effectively inhibits the activation of the enzyme Erk1/2 induced by the tissue plasminogen activator (TPA) and also effectively inhibits the apoptosis generated by the β-amyloid peptide. | 03-14-2013 |
Pilar Negredo Madrigal, Madrid ES
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20120309707 | SULPHATED DISACCHARIDES FOR THE TREATMENT OF NEURODEGENERATIVE AND/OR NEUROVASCULAR DISEASES - The present invention relates to the use of a series of sulphated disaccharides for the preparation of a medicament for the treatment or prevention of a neurodegenerative and/or neurovascular disease, of a traumatic brain injury or of a traumatic spinal cord injury. The present invention also relates to the use of said sulphated disaccharides for the preparation of a neuroprotective medicament or of an antioxidant medicament. The neurodegenerative and/or neurovascular diseases are preferably: Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and stroke. | 12-06-2012 |
Pilar Ocon Esteban, Tres Cantos ES
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20090107848 | Procedure for anodising aluminium or aluminium alloys - This invention refers to a procedure for anodising aluminium or aluminium alloys in which an aluminium or an aluminium alloy part is submerged an in an aqueous solution at a temperature between 0° C. and 140° C., preferably between 0° C. and 130° C., in which said solution includes: | 04-30-2009 |
Pilar Pámpanas, Madrid ES
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20120160414 | POLYURETHANE-ACRYLIC POLYMER DISPERSIONS AND USES THEREOF - Compositions for coating roofs roof, facades, floors or vertical facings including at least one acrylic polymer and at least one polyurethane polymer and at least one ethylene vinyl acetate emulsion. The compositions combine the advantages of the excellent features of polyurethane compositions with the reduced cost of acrylic compositions in such a manner that a balance between both characteristics is shown. Methods for covering a roof, facade, floor or vertical facing with these compositions and the use thereof as a coating for roofs, facades, floors or vertical facings. | 06-28-2012 |
Pilar Perez Cabeza, Zaragoza ES
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20120125315 | COVER PLATE FOR A DOMESTIC APPLIANCE, SAID COVER PLATE HAVING AT LEAST ONE SEMI-TRANSPARENT SUPPORT PLATE, DOMESTIC APPLIANCE FOR PREPARING FOOD AND METHOD FOR PRODUCING A COVER PLATE FOR A DOMESTIC APPLIANCE - A cover plate for a domestic appliance includes an at least semi-transparent support plate having a bottom provided with at least one colored layer and at least one semi-transparent metal layer. The metal layer has at least one continuous cut-out section and the colored layer is arranged in the area of the cut-out section. | 05-24-2012 |
20120138596 | INDUCTIVELY HEATED HOB HAVING A METAL-COATED COVER PLATE - A hob includes at least one heating inductor and a glass or glass ceramics cover plate that has at least one side coated with a metal layer coated with a metal layer. In order to improve the electromagnetic compatibility of the hob with a metal layer coating, the metal layer has a cover region which covers the heating inductor and is electrically insulated from a surrounding region of the metal layer, which surrounding region surrounds the cover region. | 06-07-2012 |
20130147751 | DOMESTIC APPLIANCE OPERATING DEVICE - A domestic-appliance-operating device, in particular a hob-operating device, includes an operating panel having a touch operating surface, a sensor plate which is arranged beneath the touch operating surface, and a touch sensor unit. A signal-transmission unit connects the sensor plate to the touch sensor unit in an electrically conductive manner by a conducting element and has at least one screening unit. | 06-13-2013 |
20130161318 | HOUSEHOLD APPLIANCE - A household appliance, in particular a cooking hob device, includes at least one thermochromic and/or thermoluminescent element that contains at least one vanadium-containing material. The material containing vanadium can be a semiconductor in at least one temperature range, e.g. a doped semiconductor in the temperature range, and may include vanadium dioxide. | 06-27-2013 |
20130248502 | PROCESS FOR PRODUCING A HOTPLATE FOR A HOB - In a method for embodying a hotplate for a hob, at least one metallic layer and a further layer under the metallic layer are formed on an underside of the hotplate. After applying the at least one metallic layer and the further layer, at least one region of the metallic layer is changed by a laser light of a laser beam so that the further layer is recognized when viewing the hob on a topside. | 09-26-2013 |
20140076881 | HOT PLATE AND HOB COMPRISING A CORRESPONDING HOT PLATE - A hot plate includes a base plate having an underside. A coating has at least two metallic layers and at least two dielectric layers and is formed on the underside of the base plate in such a way that a reflectivity of the hot plate is lower than 15% in a wavelength range between 380 nm and 780 nm. | 03-20-2014 |
20140091082 | HOUSEHOLD APPLIANCE APPARATUS - A cooktop apparatus, in particular an induction cooktop apparatus, includes at least one glass unit and at least one coating configured as a multilayer structure, which is disposed on at least one subregion of at least a main face of the glass unit and has at least two layers. In order to achieve optimum compatibility with the sensors of the user interface without requiring a process after deposition, at least one of the layers is formed by at least one semiconducting material, to fulfill the function of an absorbing layer. | 04-03-2014 |
20140197152 | HOT PLATE COMPRISING A COATING APPLIED TO THE LOWER SIDE THEREOF - A cooktop plate includes a base plate having a lower side. A coating is formed on the lower side of the base plate and includes at least two metal layers and at least two dielectric layers in such a manner that a first color parameter a* or a second color parameter b* of the cooktop plate has a value greater than +10 or smaller than −10. | 07-17-2014 |
Pilar PÉrez Lozano, Barcelona ES
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20150343066 | GEL COMPOSITIONS - The present invention provides a gel combination comprising: polycarbophil in an amount comprised from 1 to 5% by weight; polyvinylpirrolidone in an amount comprised from 4 to 8% by weight; glycerine in an amount comprised from 1 to 10% by weight; and propyleneglycolin an amount comprised from 20 to 40% by weight; wherein: the weight ratio between polyvinylpirrolidone:polycarbophil is comprised between 1:1 and 4:1, the weight ratio between glycerine:polycarbophil is comprised from 0.5:1 to 2:1, and the weight ratio propyleneglycol:polycarbophil is comprised from 8:1 to 20:1. The invention also provides transparent compositions comprising such gel combinations as well as processes for their preparation and the use thereof as a medicament. Due to the specific excipients, % by weight, and weight ratios forming the combination, the resulting compositions show a high bioadhesivity and bioavailability of the active ingredient, without toxic adverse effects. | 12-03-2015 |
Pilar Ramírez De La Piscina Millán, Barcelona ES
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20130029839 | CATALYSTS FOR THE OXIDATIVE REFORMING OF ALCOHOLS - The present invention relates to processes for the oxidative reforming of alcohols catalysed by metal catalysts on an oxide support that can be carried out at temperatures lower than 500° C., also showing a high conversion index, but maintaining a high selectivity as regards product distribution. Preferably, the starting material used in the processes is glycerol. | 01-31-2013 |
Pilar Ramírez De La Piscina Millán, Barcelona ES
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20130029839 | CATALYSTS FOR THE OXIDATIVE REFORMING OF ALCOHOLS - The present invention relates to processes for the oxidative reforming of alcohols catalysed by metal catalysts on an oxide support that can be carried out at temperatures lower than 500° C., also showing a high conversion index, but maintaining a high selectivity as regards product distribution. Preferably, the starting material used in the processes is glycerol. | 01-31-2013 |
Pilar Ruiz Aragon, Madrid ES
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20130273906 | METHOD FOR THE REDUCTION OF ENERGY COMSUMPTION AND RADIO INTERFERENCE IN A RADIO ACCESS NODE - It comprises switching on or switching off at least part of said radio access node, such as a femtonode functionality radio section and/or other radio sections, as a function of, respectively, the reception by said radio access node, of a radio signal transmitted by a wireless portable processing device, or the absence of such a reception, where said radio signal is a low-power radio signal transmitted by a low-power radio interface of said wireless portable processing device. | 10-17-2013 |
20140050128 | METHOD AND A SYSTEM FOR AVOIDING INTERFERENCES IN FREQUENCY DIVISION DUPLEX OPERATING AREAS - The method comprises coordinating the use of radio resources between different network elements including a macro base station and SCENs deployed in the coverage area of the macro base station, operating in FDD mode, by means of the sending of messages between part or all of the network elements through a synchronized TDD air interface, unidirectionally, by broadcasting, or bidirectionally, through dedicated channels. | 02-20-2014 |
20150319688 | METHOD AND SYSTEM FOR ENERGY SAVING AND MINIMIZING INTERFERENCE LEVEL IN A RADIO ACCESS NODE NETWORK DEPLOYMENT - The method comprises arranging a radio access node network deployment in a master/slave configuration, and automatically performing a switching on and/or switching off of RF transceivers of the slave radio access nodes of said radio access node network deployment. | 11-05-2015 |
Pilar Ruiz-Lozano, Menlo Park, CA US
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20160058705 | COMPOSITIONS AND METHODS FOR TREATING CARDIOVASCULAR AND PULMONARY DISEASES AND DISORDERS WITH APELIN - Compositions and methods for treating cardiovascular and pulmonary diseases and disorders with apelin are disclosed. In particular, the invention relates to formulations comprising apelin encapsulated in liposome nanocarriers conjugated with polyethylene glycol (PEG) and their use in treatment of cardiovascular and pulmonary diseases and disorders. Encapsulation of apelin in PEG-conjugated liposomes significantly enhances efficacy, improves cellular uptake of apelin, and allows for sustained and extended release of apelin under physiological conditions. | 03-03-2016 |
Pilar Ruiz-Lozano, San Diego, CA US
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20090010909 | Novel GPCR and methods of use of the same - The present invention relates to methods of identifying antagonists of GPR22, a G protein-coupled receptor (GPCR) and related compositions and methods. Antagonists of GPR22 are useful as therapeutic agents for the treatment of ischemic heart disease, including myocardial infarction, post-myocardial infarction remodeling, and congestive heart failure. | 01-08-2009 |
Pilar Sabuquillo Castrillo, Madrid ES
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20080280762 | Method of Enhancing Tomato Plant Growth - The method consists of placing the tomato seedlings in contact with a formulated | 11-13-2008 |
Pilar Sánchez Gómez, Valencia ES
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20100047212 | USE OF THE PEDF FACTOR TO INDUCE CELL REGENERATION - Use of the PEDF factor to induce cell regeneration. The present invention refers to the use of the molecule PEDF for the manufacture of medicines to activate processes included in the group of regenerative processes, such as skin regeneration, wound healing, cell therapy for cardiac, neural, or hematopoietic regeneration. It also refers to the manufacture/use of pharmaceutical compounds that contain an efficient quantity of the PEDF factor for stem cell self-renewal. | 02-25-2010 |
Pilar Sánchez Gómez, Valencia ES
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20100047212 | USE OF THE PEDF FACTOR TO INDUCE CELL REGENERATION - Use of the PEDF factor to induce cell regeneration. The present invention refers to the use of the molecule PEDF for the manufacture of medicines to activate processes included in the group of regenerative processes, such as skin regeneration, wound healing, cell therapy for cardiac, neural, or hematopoietic regeneration. It also refers to the manufacture/use of pharmaceutical compounds that contain an efficient quantity of the PEDF factor for stem cell self-renewal. | 02-25-2010 |
Pilar Sanchis Cortes, Palma De Mallorca ES
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20090035232 | FIXED-DOSE ASSOCIATION OF PHYTATE AND ZINC - The invention relates to a fixed-dose association of 5 phytate and zinc in synergic proportions for use in the treatment of crystallisation of hydroxyapatite. Advantageously, said association is in a molar ratio between the phytate and the zinc exceeding 4:1. The invention also relates to the use of said 10 association for manufacturing a drug for the treatment, prophylaxis and/or prevention crystallisation of hydroxyapatite in humans. | 02-05-2009 |
20140056994 | Fixed-Dose Association of Phytate and Zinc - The invention relates to a fixed-dose association of phytate and zinc in synergic proportions for use in the treatment of crystallization of hydroxyapatite. Advantageously, said association is in a molar ratio between the phytate and the zinc exceeding 4:1. The invention also relates to the use of said association for manufacturing a drug for the treatment, prophylaxis and/or prevention crystallization of hydroxyapatite in humans. | 02-27-2014 |
Pilar Strutin-Belinoff, Oakland, CA US
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20140006967 | CROSS-APPLICATION TRANSFERS OF USER INTERFACE OBJECTS | 01-02-2014 |
20140096048 | DRAG AND DROP SEARCHES OF USER INTERFACE OBJECTS - Example embodiments relate to drag and drop object searches within a user interface (UI) of a computing device. In example embodiments, a command is received in which a user drags a UI object from an application and drops it onto an area within the UI that is assigned to a search function. In response, a search is performed using the search function based on at least one metadata field associated with the UI object, where the metadata fields used for the search are selected based on an object type of the UI object. Finally, the results of the search are displayed within the UI. | 04-03-2014 |
Pilar Tiemblo Magro, Madrid ES
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20140031455 | METHOD FOR PRODUCING A COMPOUND BASED ON PSEUDOLAMINAR SILICATES AND THE USE THEREOF AS A FILLER FOR POLYMERIC MATERIALS - The present invention relates to a method for producing a compound that comprises a pseudolaminar silicate of natural origin, which is at least one clay of the paligorskite-sepiolite group, characterized in that said method comprises the following steps: defibrillating the microfibre bundles of the at least one clay in water; dispersing the defibrillated clay in an organic or inorganic liquid solvent until a stable gel is formed; adding to the dispersion at least one clay-surface-modifying agent; removing the solvent from the dispersion by means of a solid-liquid separation process and/or drying process; and deagglomerating the final compound until a powdered product is obtained. A further object of the present invention is the compound that can be obtained using said method, as well as the use of the compound as an additive or filler in composite polymeric materials in order to enhance the properties thereof, the composite polymeric material likewise being encompassed within the present invention. | 01-30-2014 |
Pilar Torres Zacarias, Elche (alicante) ES
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20110024702 | GYPSUM MORTAR WITH ADDED EXPANDED VERMICULITE AND METHOD FOR OBTAINING SAME - The invention relates to gypsum mortar with expanded vermiculite added with citric acid and tartaric acid and to the method for obtaining same, containing the following elements in the following proportions: between 40% and 70% calcium sulphate; between 40% and 70% laminated expanded vermiculite; between 0.05% and 0.3% citric acid; between 0.05% and 1% tartaric acid; between 0.01% and 0.5% sodium or potassium citrate; and water q.s.p. 1000 ml, in which, for surface coating, the added vermiculite is obtained following treatment in a vertical furnace, which provides improved grain size and sheets of exfoliated vermiculite without water or air, and the mortar is provided with citric acid and tartaric acid, copper sulphate and sodium or potassium scitrate, with the water being added before the mixture is produced. | 02-03-2011 |
Pilar Vela Orge, Aranjuez (madrid) ES
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20120138738 | SYSTEM FOR INCREASING CONTROLLABILITY FOR AN AIRCRAFT - The system includes deflection transmission means ( | 06-07-2012 |
Pilar Zaragoza Fernandez, Zaragoza ES
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20130316933 | METHOD FOR THE DIAGNOSIS, PROGNOSIS AND MONITORING OF MUSCULAR DEGENERATION - The invention relates to methods based on the quantification of a set of biomarkers, preferably in biological samples isolated from skeletal muscle, for performing the diagnosis, prognosis and/or monitoring of muscular degeneration, preferably muscular degeneration caused by motor neuron diseases, more preferably amyotrophic lateral sclerosis (ALS); and to a kit for the diagnosis, prognosis and monitoring of said type of diseases. The method in the invention for the prognosis and/or monitoring of muscular degeneration makes it possible to determine the rate of progression of said degeneration (fast or slow rate of progression in relation to the normal rate of progression). | 11-28-2013 |