Hope, CA
Andrew Hope, Toronto CA
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20120155731 | QUANTITATIVE ENDOSCOPY - A method, computer program product and processor for quantitatively registering a 2D endoscopic ROI in a 3D volumetric imaging dataset. An endoscopic dataset and a volumetric imaging are registered to a common coordinate system. A 2D endoscopic ROI is generated within the endoscopic imaging dataset. A 3D surface ROI is generated within the volumetric imaging dataset corresponding to the 2D endoscopic ROI, based on a projection of the 2D endoscopic ROI to the registered common coordinate system. | 06-21-2012 |
20130113802 | METHODS AND SYSTEMS FOR VISUALIZATION OF 3D PARAMETRIC DATA DURING 2D IMAGING - Methods and systems for visualization of 3D parametric data in a 2D image. The set of 3D parametric data includes a plurality of voxels in 3D space each associated with at least one parametric value, and the set of 2D image data includes information about a known camera position and a known camera orientation at which the 2D image was obtained. A graphical representation is generated of the parametric values of the voxels corresponding to a viewing surface in 3D space. A virtual 2D view of the viewing surface is determined. The 2D image is displayed registered with the graphical representation of the parametric values of the voxels corresponding to the virtual 2D view. | 05-09-2013 |
Douglas Albert Hope, Mississauga CA
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20090078649 | METHOD FOR SELECTIVE REMOVAL OF CADMIUM - A method for selective removal of cadmium from a feed solution also containing other metals such as nickel (Ni) and/or cobalt (Co), utilizing a thiourea based ion exchange resin, and a method for eluting cadmium adsorbed on the thiourea based resin. | 03-26-2009 |
Erik P. Hope, Calgary CA
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20080209033 | Event monitoring and management - Described are techniques used in monitoring the performance, security and health of a system used in an industrial application. Agents included in the industrial network report data to an appliance or server. The appliance stores the data and determines when an alarm condition has occurred. Notifications are sent upon detecting an alarm condition. The alarm thresholds may be user defined. A threat thermostat controller determines a threat level used to control the connectivity of a network used in the industrial application. | 08-28-2008 |
20100023598 | Event monitoring and management - Described are techniques used in monitoring the performance, security and health of a system used in an industrial application. Agents included in the industrial network report data to an appliance or server. The appliance stores the data and determines when an alarm condition has occurred. Notifications are sent upon detecting an alarm condition. The alarm thresholds may be user defined. A threat thermostat controller determines a threat level used to control the connectivity of a network used in the industrial application. | 01-28-2010 |
20100064039 | Event monitoring and management - Described are techniques used in monitoring the performance, security and health of a system used in an industrial application. Agents included in the industrial network report data to an appliance or server. The appliance stores the data and determines when an alarm condition has occurred. Notifications are sent upon detecting an alarm condition. The alarm thresholds may be user defined. A threat thermostat controller determines a threat level used to control the connectivity of a network used in the industrial application. | 03-11-2010 |
Frederick Eugene Hope, Calgary CA
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20130291917 | SHELTER BARRIER MEMBER - According to a first embodiment of the present invention there is disclosed an apparatus for forming a shelter comprising a pair of parallel spaced apart beams, a flexible barrier sheet extending between the pair of beams and at least two braces extending between the beams. Each of the braces are foldable along a plane defined by an adjacent portion of the pair or beams and may be formed of first and second elongate members substantially similar lengths pivotally connected to each other which are foldable to be substantially parallel to the beams in a first position and substantially perpendicular to the beams in a second position. | 11-07-2013 |
Kristin Hope, Toronto CA
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20110294692 | USE OF MIR-126 FOR ENHANCING HEMATOPOIETIC STEM CELL ENGRAFTMENT, FOR ISOLATING HEMATOPOIETIC STEM CELLS, AND FOR TREATING AND MONITORING THE TREATMENT OF ACUTE MYELOID LEUKEMIA - There is disclosed herein composition, methods and uses relating to miR-126 as a measure of engraftment potential of a population of hematopoietic stem cells (HSCs), as a method of purifying HSCs and in the monitoring or treatment of acute myeloid leukemia. | 12-01-2011 |
Michael J. Hope, Vancouver CA
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20080200417 | HIGH EFFICIENCY ENCAPSULATION OF CHARGED THERAPEUTIC AGENTS IN LIPID VESICLES - Methods for the preparation of a lipid-nucleic acid composition are provided. According to the methods, a mixture of lipids containing a protonatable or deprotonatable lipid, for example an amino lipid and a lipid such as a PEG- or Polyamide oligomer-modified lipid is combined with a buffered aqueous solution of a charged therapeutic agent, for example polyanionic nucleic acids, to produce particles in which the therapeutic agent is encapsulated in a lipid vesicle. Surface charges on the lipid particles are at least partially neutralized to provide surface-neutralized lipid-encapsulated compositions of the therapeutic agents. The method permits the preparation of compositions with high ratios of therapeutic agent to lipid and with encapsulation efficiencies in excess of 50%. | 08-21-2008 |
20090285878 | Compositions and methods for stabilizing liposomal drug formulations - The present invention is directed to liposomal compositions comprising a camptothecin, which are optimized to reduce camptothecin degradation and/or precipitation of camptothecin degradation products in the external medium. The invention further provides improved methods of formulating liposomal camptothecins, kits comprising liposome-encapsulated camptothecins, and methods of using the same to treat a variety of diseases and disorders, including cancer. | 11-19-2009 |
20100041152 | METHODS FOR ENCAPSULATING PLASMIDS IN LIPID BILAYERS - Plasmid-lipid particles which are useful for transfection of cells in vitro or in vivo are described. The particles can be formed using either detergent dialysis methods or methods which utilize organic solvents. The particles are typically 65-85 nm, fully encapsulate the plasmid and are serum-stable. | 02-18-2010 |
20110097720 | SCREENING METHOD FOR SELECTED AMINO LIPID-CONTAINING COMPOSITIONS - The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-Dilinoley 1-4-dimethylaminomethyl-[1,3]-dioxolane by screening for an effect of the agent on the liver of a model subject. | 04-28-2011 |
20110117125 | COMPOSITIONS AND METHODS FOR THE DELIVERY OF NUCLEIC ACIDS - The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art. | 05-19-2011 |
20110256175 | AMINO LIPIDS AND METHODS FOR THE DELIVERY OF NUCLEIC ACIDS - The present invention provides superior compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target proteins at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art. | 10-20-2011 |
20120114831 | HIGH EFFICIENCY ENCAPSULATION OF CHARGED THERAPEUTIC AGENTS IN LIPID VESICLES - Methods for the preparation of a lipid-nucleic acid composition are provided. According to the methods, a mixture of lipids containing a protonatable or deprotonatable lipid, for example an amino lipid and a lipid such as a PEG- or Polyamide oligomer-modified lipid is combined with a buffered aqueous solution of a charged therapeutic agent, for example polyanionic nucleic acids, to produce particles in which the therapeutic agent is encapsulated in a lipid vesicle. Surface charges on the lipid particles are at least partially neutralized to provide surface-neutralized lipid-encapsulated compositions of the therapeutic agents. The method permits the preparation of compositions with high ratios of therapeutic agent to lipid and with encapsulation efficiencies in excess of 50%. | 05-10-2012 |
20120225434 | SCREENING METHOD FOR SELECTED AMINO LIPID-CONTAINING COMPOSITIONS - The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-Dilinoley 1-4-dimethylaminomethyl-[1,3]-dioxolane by screening for an effect of the agent on the liver of a model subject. | 09-06-2012 |
20130017223 | METHODS AND COMPOSITIONS FOR DELIVERY OF NUCLEIC ACIDS - A lipid particle can include a plurality of cationic lipids, such as a first cationic lipid and a second cationic lipid. The first cationic lipid can be selected on the basis of a first property and the second cationic can be selected on the basis of a second property. The first and second properties are complementary. The attributes of the lipid particle can reflect the selected properties of the cationic lipids, and the complementary nature of those properties. | 01-17-2013 |
Nicholas Hope, Campbellville CA
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20100213290 | NOZZLE REPAIR TO REDUCE FRETTING - A method repair for reducing fretting of a fuel nozzle of a gas turbine engine, including attaching at least one stiffening element to an outer surface of a portion of a stem member of the fuel nozzle, with a size and shape of the at least one stiffening element being selected such that a first natural frequency of the fuel nozzle with the at least one stiffening element attached thereto is outside the engine running frequency range. | 08-26-2010 |
Shaun Hope, Alameda CA
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20110066299 | SYSTEM AND METHOD OF MODELING AND MONITORING AN ENERGY LOAD - A system, method, and computer program product for predicting operation for physical systems with distinct operating modes uses observable qualities of the system to predict other qualities of the system. Independent variables including temperature or production volume are observed to determine the degree to which a dependent modeled variable, including energy load, is influenced. Partition variables representing operating conditions of the dependent variables are defined as discrete values. Reference datasets with coincident values of the dependent variable, independent variable, and partition variables are received, and models are created for each discrete value of the partition variables in the reference dataset. Each model is populated with the values of the dependent variable and the independent variable. The dependent variable is modeled as a function of the independent variable. Model accuracy is evaluated by processing new input data to generate output data that includes values of the coincident dependent variable, the independent variable, and the partition variable from the input dataset. | 03-17-2011 |