Mitchell, MD
Archer S. Mitchell, Silver Spring, MD US
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20090194870 | Method and Apparatus for Solid State Cooling System - The disclosure relates to a Point Cooler based on a combination of principles, including large area, low current density PN junction cooling, and electron emission from heavily doped shallowly-depleted P tips. Using Junction Cooling rather than thermoelectric cooling enables an all silicon device to be made that favorably competes with the commercial thermoelectric cooling systems. Theoretical values of T | 08-06-2009 |
Braxton D. Mitchell, Towson, MD US
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20110033444 | Genetic variants in a hypertension susceptibility gene Stk39 and uses thereof - The present invention is drawn to diagnosis and treatment of essential hypertension. In this regard, the present invention discloses genetic variants in a hypertension susceptibility gene Stk39 and its use in the diagnosis and treatment of essential hypertension. | 02-10-2011 |
Gary Mitchell, Woodbine, MD US
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20140317312 | System and Methods for Dynamic Network Address Modification - The invention presented herein permits split-routing to occur without any changes, modifications, or configuration of the requesting host, network stacks, network architectures and routing and forwarding behavior. The invention is carried out by way of a Module that intercepts the normal and standard DHCP communication between a requesting device and a DHCP server, and substitutes the elements within the server response with the Module's own predefined elements. These substitute elements leverage the behavior of standard protocols to gain desired device network behavior. | 10-23-2014 |
Gregory A. Mitchell, Olney, MD US
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20120062330 | RADIO FREQUENCY INTEGRATED CIRCUIT FOR ENHANCED TRANSMIT/RECEIVE PERFORMANCE IN LOW POWER APPLICATIONS AND METHOD OF MAKING THE SAME - A radio frequency integrated circuit (and method of making) for enhancing wireless communication and/or sensing systems comprising a base comprising a gallium arsenide (GaAs) substrate; a binary phase shift keying modulator fabricated on the base; a power amplifier fabricated on the base and operatively associated with the binary phase shift keying modulator; the power amplifier having a first shunt operatively associated therewith; a transmit/receive switch fabricated on the base, the transmit/receive switch being operatively associated with the power amplifier and being alternately connectable to an antenna port adapted to be connected to an antenna; a low noise amplifier fabricated on the base; the low noise amplifier being alternately connectable to the antenna port, the low noise amplifier having a second shunt operatively associated therewith; the circuit operating in a transmit stage in which the power amplifier is connected to the antenna port and in a receive stage in which the low noise amplifier is connected to the antenna port; whereby in the receive stage the power amplifier is bypassed by the first shunt to reduce current consumption and substantially isolate the receive stage from the transmit stage; and in the transmit stage the low noise amplifier is bypassed by the second shunt to reduce current consumption and to substantially isolate the transmit stage from the receive stage. | 03-15-2012 |
Gregory Allen Mitchell, Olney, MD US
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20100052652 | APPARATUS AND METHOD FOR SPURIOUS-FREE SIGNAL RANGE MEASUREMENT FOR RF CIRCUITRY - The present invention is directed to an apparatus and methodology for performing spurious-free dynamic range (SFDR) measurements on an RF circuit, such as a mixer, using a single analog input port. The present invention is designed for use when access to the intermediate frequency (IF) port in a radio frequency (RF) front-end circuit is not available, when the traditional two-port method for making an SFDR measurement is inadequate. Passing the analog input through a directional coupler between the RF combiner and the mixer facilitates the performance of the traditional third order intermodulation (IMD) test. Key differences between the single-port and traditional two-port setups are considered and examined, and experimental data obtained using the single-port setup is compared to data obtained using the traditional two-port set-up for different mixer models. Comparison of similar results yields confirmation and a calibration to account for the additional losses introduced by the directional coupler. | 03-04-2010 |
James B. Mitchell, Sykesville, MD US
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20110051555 | System and Method for Determining Location of Submerged Submersible Vehicle - An aspect of the present invention is drawn to method of determining a location of a submersible vehicle. The method includes obtaining first bearing information based on a location of a ship at a first time relative to the submersible vehicle and receiving broadcast information from the ship, wherein the broadcast information includes location information related to a second location of the ship at a second time, a velocity of the ship at the second time and a course of the ship at the second time. The method further includes obtaining second bearing information based on the second location of the ship at the second time relative to the submersible vehicle, obtaining a velocity of the submersible vehicle at the second time and obtaining a course of the submersible vehicle at the second time. The method still further includes determining the location of the submersible vehicle based on the first bearing information, the second location of the ship at the second time, the velocity of the ship at the second time, the course of the ship at the second time, the second bearing information, the velocity of the submersible vehicle at the second time and the course of the submersible vehicle at the second time. | 03-03-2011 |
20140085004 | System and Method for Determining Location of Submerged Submersible Vehicle - An amplifier for use in a buoyant cable antenna operable to receive signals within a frequency band includes: a first amplifier operable to provide amplified signals based on the received signals; a bandpass filter arranged to pass filtered signals within a first portion of the frequency band, the filtered signals being based on the amplified signals; an attenuator arranged in parallel with said bandpass filter and operable to attenuate signals within a second portion of the frequency band, the attenuated signals being based on the amplified signals; and a second amplifier operable to provide an amplified output including first amplified signals within the first portion of the frequency band and to provide second amplified signals within the second portion of the frequency band. The first amplified signals have a first gain, the second amplified signals have a second gain, and the first gain is more than the second gain. | 03-27-2014 |
James B. Mitchell, Damascus, MD US
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20090028798 | METHOD FOR DETERMINING REDOX STATUS OF A TISSUE - Disclosed is a method for determining the redox status of a region of interest in an animal tissue. The method includes administering a nitroxyl contrast agent to the region of interest, obtaining a magnetic resonance image of the region of interest, determining the amount of reduced nitroxyl contrast agent in the region of interest, and thereby determining the redox status of the region of interest. | 01-29-2009 |
20100148776 | FAST ELECTRON PARAMAGNETIC RESONANCE IMAGING (EPRI) USING CW EPR SPECTROMETER WITH SINUSOIDAL RAPID-SCAN AND DIGITAL SIGNAL PROCESSING - An electron paramagnetic resonance imaging system that includes means for continuously irradiating a sample with RF irradiation; means for imposing on the sample a sinusoidally varying magnetic field along with rotating gradients for spatial encoding; means for directly detecting signal data from the sample, without using field modulation, while irradiating the sample with RF radiation continuously, the means for directly detecting having means for sweeping the sinusoidally varying magnetic field; and means for processing the signal data, using means including a digital signal processor. | 06-17-2010 |
20100168165 | METHOD OF TREATING DISEASE INVOLVING MYELIN AND/OR AXONAL LOSS - Disclosed is a method of treating a disease involving myelin and/or axonal loss, such as a demyelinating disease, in a mammal comprising administering a compound of formula I | 07-01-2010 |
20100179188 | NITROXIDE RADICAL AS TREATMENT FOR NEURODEGENERATION - A method of treating or preventing neurodegeneration in a mammal comprising administering to the mammal an effective amount of a stable nitroxide radical, such as Tempo | 07-15-2010 |
20110109313 | FAST ELECTRON PARAMAGNETIC RESONANCE IMAGING (EPRI) IN THE CW EPR MODE USING RAPID-SCAN IN THE PRESENCE OF ROTATING GRADIENTS AND DIRECT DETECTION WITH TRANSMIT/RECEIVE & DATA PROCESSING IN A DIGITAL SIGNAL PROCESSING PLATFORM - An electron paramagnetic resonance imaging system that includes means for continuously irradiating a sample with RF irradiation; means for imposing on the sample a sinusoidally varying magnetic field along with rotating gradients for spatial encoding; means for directly detecting signal data from the sample, without using field modulation, while irradiating the sample with RF radiation continuously, the means for directly detecting having means for sweeping the sinusoidally varying magnetic field; and means for transmitting, receiving and processing the signal data, using means including a digital signal processor. | 05-12-2011 |
20110313279 | QUANTITATIVE OXYGEN IMAGING SYSTEMS AND METHODS USING ECHO-BASED SINGLE POINT IMAGING - An echo-based single point imaging (ESPI) system ( | 12-22-2011 |
20120263650 | NITROXIDE MODIFIED NON-STEROIDAL ANTI-INFLAMMATORY COMPOUNDS AND USES THEREOF IN THE TREATMENT AND PREVENTION OF DISEASES OR DISORDERS - Disclosed are nitroxide modified NSAID compounds of the formula (I) or a pharmaceutically acceptable salt or enantiomer thereof: | 10-18-2012 |
20140045796 | TRANSIENT HYPOXIA INDUCERS AND THEIR USE - The identification of pO | 02-13-2014 |
20140066472 | METHODS OF PREVENTING THE DEVELOPMENT OF MUCOSITIS AND RELATED DISORDERS - Disclosed is a method of preventing the development of mucositis in a subject undergoing radiation therapy or chemotherapy for a disease in need thereof comprising administering an effective amount of a mammalian target of rapamycin (mTOR) inhibitor, such as rapamycin, to the subject. Further disclosed is a method of increasing the lifespan of a normal oral keratinocyte and/or reducing oxidative stress in a normal epithelial cell, wherein the method comprises administering an effective amount of an mTOR inhibitor to a subject undergoing radiation therapy or chemotherapy for a disease in need thereof. | 03-06-2014 |
James J. Mitchell, Cambridge, MD US
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20140261109 | ARCHITECTURAL MESH BLAST SCREEN SYSTEM - A blast screen system for a framed opening including a mounting mechanism secured to the framed opening; and a flexible mesh panel secured by the mounting mechanism to cover the framed opening. The mounting mechanism includes a plurality of spring biased brackets, each having a first portion and a second portion, the first and second portions being joined by a pivot pin. | 09-18-2014 |
20140262085 | ARCHITECTURAL MESH FRAMING SYSTEM - A framed architectural mesh panel system including a mesh panel; a frame assembly; and a tensioning system; wherein the tensioning system is integrated within the frame assembly. | 09-18-2014 |
Kathy E. Mitchell, Columbia, MD US
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20100284978 | CULTURES, PRODUCTS AND METHODS USING UMBILICAL CORD MATRIX CELLS - Stem cells from human sources can have a variety of useful applications in disease treatment and biotechnology. More particularly the umbilical cord matrix cell cultures of the invention have a variety of totipotent, pluripotent, or multipotent cells for a variety of end uses from a non-controversial, universally available, species-specific source. The technology can have application to any amniotic animal, including agricultural and laboratory animals and humans. The invention relates to isolating the stem cells, culturing the stem cells, maintaining the stem cells, transforming the stem cells into useful cell types using genetic or other transformation technologies, stem cell and tissue banking and using untransformed or transformed cells in disease treatment. | 11-11-2010 |
Lloyd G. Mitchell, Bethesda, MD US
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20090203143 | TRANS-SPLICING MEDIATED PHOTODYNAMIC THERAPY - The present invention provides methods and compositions for conferring selective death on cells expressing a specific target precursor messenger RNA (selective target pre-mRNA). The compositions of the invention include pre-trans-splicing molecules (PTMs) designed to interact with a target precursor messenger RNA molecule (target pre-mRNA) expressed within a cell and mediate a trans-splicing reaction resulting in the generation of a novel chimeric mRNA molecule (chimeric mRNA) capable of encoding a light producing protein or enzyme. Cell death is further mediated by the presence of a photosensitizer which upon photoactivation produces cytotoxicity. | 08-13-2009 |
20130059901 | Pre-MRNA Trans-Splicing Molecule (RTM) Molecules and Their Uses - The present invention relates to specific and markedly improved pre-mRNA trans-splicing molecule (RTM) molecules which are designed to correct specific genes expressed within cells to be targeted, and which are associated with epidermolysis bullosa, cystic fibrosis, pachyonychia congenital, and psoriasis or neurodermitis, as well as cancers of the skin. In particular, the RTMs of the present invention are genetically engineered to interact with a specific target pre-mRNA expressed in cells to be targeted so as to result in correction of genetic defects or reprogramming of gene expression responsible for a variety of different skin disorders. | 03-07-2013 |
Matthew L. Mitchell, Bethesda, MD US
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20090022452 | MONOLITHIC TRANSMITTER PHOTONIC INTEGRATED CIRCUIT (TXPIC) WITH A TRANSVERSELY DISPOSED OUTPUT - A photonic integrated circuit (PIC) chip comprising an array of modulated sources, each providing a modulated signal output at a channel wavelength different from the channel wavelength of other modulated sources and a wavelength selective combiner having an input optically coupled to received all the signal outputs from the modulated sources and provide a combined output signal on an output waveguide from the chip. The modulated sources, combiner and output waveguide are all integrated on the same chip. | 01-22-2009 |
20110249936 | TRANSMITTER PHOTONIC INTEGRATED CIRCUIT (TxPIC) CHIP - A photonic integrated circuit (PIC) chip comprising an array of modulated sources, each providing a modulated signal output at a channel wavelength different from the channel wavelength of other modulated sources and a wavelength selective combiner having an input optically coupled to received all the signal outputs from the modulated sources and provide a combined output signal on an output waveguide from the chip. The modulated sources, combiner and output waveguide are all integrated on the same chip. | 10-13-2011 |
Roger A. Mitchell, Chevy Chase, MD US
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20120224772 | Correlated Land Change System and Method - A system and method of mapping a persistent feature change of image data at a geographic location includes selecting a plurality of satellite images from a geographic location on different dates, producing a plurality of two-date satellite change images from pairs of the satellite images, comparing the plurality of satellite change images, and detecting a persistent feature change of image data in the compared satellite change images. | 09-06-2012 |
Steven Mitchell, Annapolis, MD US
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20140146303 | REMOTE MEASUREMENT OF SHALLOW DEPTHS IN SEMI-TRANSPARENT MEDIA - Through discrimination of the scattered signal polarization state, a lidar system measures a distance through semi-transparent media by the reception of scattered signals from a first surface and scattered signals from a second surface. Combined and overlapped light signals scattered from the two surface signals can be separated by exploiting their differing polarization characteristics. This removes the traditional laser and detector pulse width limitations that determine the system's operational bandwidth, translating relative depth measurements into the conditions of single surface timing measurements and achieving sub-pulse width resolution. | 05-29-2014 |