Patent application number | Description | Published |
20090191263 | COMPOSITIONS AND METHODS FOR SIRNA INHIBITION OF HIF-1 ALPHA - RNA interference using small interfering RNAs which target HIF-1 alpha mRNA inhibit expression of the HIF-1 alpha gene. As HIF-1 alpha is a transcriptional regulator of VEGF, expression of VEGF is also inhibited. Control of VEGF production through siRNA-mediated down-regulation of HIF-1 alpha can be used to inhibit angiogenesis, in particularly in diseases such as diabetic retinopathy, age related macular degeneration and many types of cancer. | 07-30-2009 |
20100136101 | COMPOSITIONS AND METHODS FOR SIRNA INHIBITION OF HIF-1 ALPHA - RNA interference using small interfering RNAs which target HIF-1 alpha mRNA inhibit expression of the HIF-1 alpha gene. As HIF-1 alpha is a transcriptional regulator of VEGF, expression of VEGF is also inhibited. Control of VEGF production through siRNA-mediated down-regulation of HIF-1 alpha can be used to inhibit angiogenesis, in particularly in diseases such as diabetic retinopathy, age related macular degeneration and many types of cancer. | 06-03-2010 |
20120308645 | COMPOSITIONS AND METHODS FOR SIRNA INHIBITION OF HIF-1 ALPHA - RNA interference using small interfering RNAs which target HIF-1 alpha mRNA inhibit expression of the HIF-1 alpha gene. As HIF-1 alpha is a transcriptional regulator of VEGF, expression of VEGF is also inhibited. Control of VEGF production through siRNA-mediated down-regulation of HIF-1 alpha can be used to inhibit angiogenesis, in particularly in diseases such as diabetic retinopathy, age related macular degeneration and many types of cancer. | 12-06-2012 |
Patent application number | Description | Published |
20110068840 | USE OF DATA DECISIONS FOR TEMPORAL PLACEMENT OF SAMPLERS - A data receiver has a clock recovery and data sampling circuit. This has a fixed local oscillator for timing the data samples. A phase interpolator adjusts the phase of the clock signal in response to an early late detector which samples the waveform at the expected position of the edges. A further correction to the sampling position is made in response to the recent history of the data received. The correction is modelled on predictable jitter, for example, that in a transmitter caused by changes in data causing the supply voltage to drop. | 03-24-2011 |
20140198837 | Methods and Systems for Chip-to-Chip Communication with Reduced Simultaneous Switching Noise - Systems and methods are described for transmitting data over physical channels to provide a high speed, low latency interface such as between a memory controller and memory devices with significantly reduced or eliminated Simultaneous Switching Output noise. Controller-side and memory-side embodiments of such channel interfaces are disclosed which do not require additional pin count or data transfer cycles, have low power utilization, and introduce minimal additional latency. In some embodiments of the invention, three or more voltage levels are used for signaling. | 07-17-2014 |
20140254642 | Methods and Systems for High Bandwidth Chip-to-Chip Communications Interface - Systems and methods are described for transmitting data over physical channels to provide a high bandwidth, low latency interface between integrated circuit chips with low power utilization. Communication is performed using group signaling over multiple wires using a vector signaling code, where each wire carries a low-swing signal that may take on more than two signal values. | 09-11-2014 |
20150349835 | METHODS AND SYSTEMS FOR HIGH BANDWIDTH CHIP-TO-CHIP COMMUNCATIONS INTERFACE - Systems and methods are described for transmitting data over physical channels to provide a high bandwidth, low latency interface between integrated circuit chips with low power utilization. Communication is performed using group signaling over multiple wires using a vector signaling code, where each wire carries a low-swing signal that may take on more than two signal values. | 12-03-2015 |
20150381768 | Methods and Systems for Chip-to-Chip Communication with Reduced Simultaneous Switching Noise - Systems and methods are described for transmitting data over physical channels to provide a high speed, low latency interface such as between a memory controller and memory devices with significantly reduced or eliminated Simultaneous Switching Output noise. Controller-side and memory-side embodiments of such channel interfaces are disclosed which do not require additional pin count or data transfer cycles, have low power utilization, and introduce minimal additional latency. In some embodiments of the invention, three or more voltage levels are used for signaling. | 12-31-2015 |
Patent application number | Description | Published |
20090028692 | Systems and Methods for Providing Vane Platform Cooling - Systems and methods for cooling vane platforms are provided. In this regard, a representative method for cooling a vane platform includes: providing a cooling channel on a platform from which a vane airfoil extends, the cooling channel being defined by a cooling surface and a channel cover, the channel wall being spaced from the cooling surface and located such that the cooling surface is positioned between a gas flow path of the vane and the channel cover; and directing a flow of cooling air through the cooling channel such that heat is extracted from the cooling surface of the platform by the flow of cooling air. | 01-29-2009 |
20100054915 | AIRFOIL INSERT - An airfoil insert comprises an insert wall, a contact element and a flow director. The insert wall defines an interior extending inside the insert wall from a first end to second end, and an exterior extending outside the insert wall from the first end to the second end. The contact element is formed on the exterior of the insert wall. The flow director is formed on the insert wall at a boundary between the interior and the exterior. The flow director increases a heat transfer coefficient of convective flow along the insert wall by directing the convective flow to the exterior of the insert wall. | 03-04-2010 |
20100129195 | Castings, Casting Cores, and Methods - The pattern has a pattern material and a casting core combination. The pattern material has an airfoil. The casting core combination is at least partially embedded in the pattern material. The casting core combination comprises a plurality of metallic casting cores. Each metallic casting core has opposite first and second faces and a respective portion along the trailing edge of the airfoil. At least two of the metallic cores have sections offset between the pressure side and the suction side. | 05-27-2010 |
20110070082 | GAS TURBINE ENGINE COMPONENT COOLING SCHEME - A method of cooling a gas turbine engine component includes creating a cooling channel within a platform of the component, communicating cooling air into the cooling channel to cool the platform, and recycling the cooling airflow used to cool the platform by communicating the cooling airflow from the cooling channel into the airfoil to cool the airfoil. | 03-24-2011 |
20110070097 | GAS TURBINE ENGINE COMPONENT COOLING SCHEME - A gas turbine engine includes a compressor section, a combustor section and a turbine section. The turbine section includes components having a platform and an airfoil extending from the platform. The platform includes an outer surface, a cover plate and a cooling channel extending between the outer surface and the cover plate. The cooling channel receives cooling airflow to cool the platform and the airfoil. | 03-24-2011 |
20120076661 | BLADE FOR A GAS TURBINE ENGINE - A rotor blade for a turbine engine includes a first side that defines a first contact face with a hardcoat and a second side that defines a second contact face without a hardcoat. | 03-29-2012 |
20150345322 | VANE SUPPORT SYSTEMS - A vane support system includes a frame and a vane. The frame has a first end configured to engage to a first platform and a second end configured to engage a second platform, so the frame can structurally support at least one of the first platform and the second platform. The first and second ends define a vane axis therebetween. The vane is mounted to the frame about the vane axis. A gas turbine engine includes a case defining a centerline axis of the engine, an inner housing and a plurality of variable vanes. The inner housing is radially inward of the case with respect to the centerline axis. At least one of the variable vanes structurally supports the case and the inner housing in response to at least one of radial, axial or tangential loads with respect to the centerline axis. | 12-03-2015 |
20150361822 | VARIABLE AREA VANE ARRANGEMENT FOR A TURBINE ENGINE - An adjustable stator vane for a turbine engine includes a shaft, a flange and a stator vane body that pivots about a variable vane axis. The stator vane body extends axially between a first end and a second end. The stator vane body includes an airfoil, a cavity, and a body surface located at the first end. The cavity extends axially from an inlet in the body surface and into the airfoil. The shaft extends along the variable vane axis from the first end. The flange extends circumferentially around the inlet and the shaft, and radially from the stator vane body. | 12-17-2015 |
20150369079 | MULTI-SEGMENT ADJUSTABLE STATOR VANE FOR A VARIABLE AREA VANE ARRANGEMENT - An assembly for a turbine engine includes a plurality of vane segments. The vane segments are fastened together and form an adjustable stator vane that pivots about a variable vane axis. The adjustable stator vane includes a stator vane body, a shaft and a flange. The stator vane body extends axially between a first end and a second end, and includes an airfoil, a body surface and a cavity. The body surface is located at the first end. The cavity extends axially from an inlet in the body surface and into the airfoil. The shaft extends along the variable vane axis from the first end. The flange extends circumferentially at least partially around the inlet, and radially from the stator vane body. A first of the vane segments includes the flange. A second of the vane segments includes at least a portion of the airfoil. | 12-24-2015 |