Joost
Joost Brasz, Fayetteville, NY US
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20100263380 | CASCADED ORGANIC RANKINE CYCLE (ORC) SYSTEM USING WASTE HEAT FROM A RECIPROCATING ENGINE - A method and system for operating a cascaded organic Rankine cycle (ORC) system ( | 10-21-2010 |
20100263391 | Control Device for HVAC Systems with Inlet and Outlet Flow Control Devices - A process for controlling operation of a heating, ventilation and air conditioning system broadly comprises providing a heating, ventilation and air conditioning system having an evaporator, a condenser, a compressor having an inlet and an outlet, and at least one flow control device; measuring a performance parameter of the heating, ventilation and air conditioning system; determining a performance parameter measurement of the flow indicative of onset of surge; determining a surge line of the heating, ventilation and air conditioning system based upon the performance parameter measurement; and independently controlling the at least one flow control device based upon the performance parameter to mitigate an onset of the surge. | 10-21-2010 |
20120219431 | Centrifugal Compressor Part Load Control Algorithm for Improved Performance - A compressor system having a centrifugal compressor, controller and an interface is disclosed. The compressor includes adjustable guide vanes and a variable geometry diffuser. The controller is in electrical communication with each of the guide vanes and diffuser so as to monitor and adjust positions thereof in accordance with a predetermined control algorithm. The control algorithm is implemented in accordance with a method of controlling the centrifugal compressor. The method adjusts the position of the diffuser based on the actual lift, guide vane position and predetermined relationships between diffuser position and reference lift. | 08-30-2012 |
20130036760 | CENTRIFUGAL COMPRESSOR WITH FLUID INJECTOR DIFFUSER - A centrifugal compressor includes a housing providing in inlet, an impeller, a diffuser and a volute or collector. An electric motor is provided in the housing and is configured to drive at least one impeller via a shaft about an axis. The impeller includes an outlet end aligned with a diffuser and arranged at the throat. A variable fluid injector device is arranged downstream from the outlet end of the impeller in one example. The variable fluid injector device is configured to introduce high pressure fluid downstream from the impeller in response to a compressor regulation command. The injected fluid energizes the low momentum boundary layer, which provides compressor stability. A compressor controller is in communication with the variable fluid injection device to obtain a desired compressor operating condition. | 02-14-2013 |
20130064682 | VARIABLE-SPEED OIL-FREE REFRIGERANT CENTRIFUGAL COMPRESSOR WITH VARIABLE GEOMETRY DIFFUSER - A refrigerant compressor includes a housing providing a refrigerant outlet having a throat. An electric motor is provided in the housing to directly drive an impeller via a shaft about an axis in response to a variable speed command. The impeller includes an outlet end aligned with variable geometry diffuser. A magnetic bearing assembly rotationally supports the shaft relative to the housing in response to a magnetic bearing command. A member is arranged to adjust the throat area, and which can move in a direction generally parallel to the axis in response to an actuator receiving a compressor regulation command. A controller is configured to respectively provide the variable speed command, the magnetic bearing command and the compressor regulation command to the electric motor to vary throat area, the magnetic bearing assembly and the actuator to obtain a desired compressor operation without the need of variable inlet geometry. | 03-14-2013 |
20140182317 | Economized Centrifugal Compressor - A compressor ( | 07-03-2014 |
20140208788 | CENTRIFUGAL COMPRESSOR WITH EXTENDED OPERATING RANGE - This disclosure relates to a centrifugal compressor. In a first example, the compressor includes a first impeller provided in a main refrigerant flow path, a second impeller provided in the main refrigerant flow path downstream of the first impeller, and a recirculation flow path. In the first example, the recirculation flow path is provided between a first location and a second location along the main refrigerant flow path. The first location is downstream of the second location, and the second location is downstream of the first impeller. In a second example, the compressor includes an impeller provided in a main refrigerant flow path, and a recirculation flow path provided between a first location and a second location along the main refrigerant flow path. In the second example, the recirculation flow path includes a recirculation volute. Further disclosed is a method for operating a centrifugal compressor. | 07-31-2014 |
20140356138 | VARIABLE-SPEED MULTI-STAGE REFRIGERANT CENTRIFUGAL COMPRESSOR WITH DIFFUSERS - A refrigeration system includes a chiller having a refrigerant loop. A compressor is part of and in fluid communication with the refrigerant loop. The compressor has two stages, one with a variable geometry diffuser and one with a fixed geometry diffuser. | 12-04-2014 |
20150107289 | HIGH PRESSURE RATIO MULTI-STAGE CENTRIFUGAL COMPRESSOR - A heat pump system includes a refrigerant circuit. First and second heat exchangers are arranged in the refrigerant circuit. A flow reversing device selectively changes a direction of flow in the refrigerant circuit between the first and second heat exchangers. A centrifugal compressor is arranged in the fluid circuit and has first and second impellers arranged in series relative to one another to provide a desired compressor pressure ratio. In one example, the centrifugal compressor mounts the first and second impellers on opposing ends of a shaft. The first and second impellers respectively include first and second stage inlets and outlets. One example desired compressor pressure ratio of at least 10:1 corresponds to a second stage outlet pressure to a first stage inlet pressure. A first diffuser is arranged at the first stage outlet, and the first diffuser is a variable geometry diffuser. | 04-23-2015 |
20150128640 | TWO-STAGE CENTRIFUGAL COMPRESSOR WITH EXTENDED RANGE AND CAPACITY CONTROL FEATURES - One exemplary embodiment of this disclosure relates to a centrifugal refrigerant compressor system. The system includes a condenser, an evaporator, and an economizer between the condenser and the evaporator. The system further includes a centrifugal compressor having a first impeller and a second impeller downstream of the first impeller. The compressor includes at least one port. Fluid from a recirculation flow path and an economizer flow path is introduced into a main flow path of the compressor by way of the at least one port. | 05-14-2015 |
20150354589 | CENTRIFUGAL COMPRESSOR WITH EXTENDED OPERATING RANGE - This disclosure relates to a centrifugal compressor. In a first example, the compressor includes a first impeller provided in a main refrigerant flow path, a second impeller provided in the main refrigerant flow path downstream of the first impeller, and a recirculation flow path. In the first example, the recirculation flow path is provided between a first location and a second location along the main refrigerant flow path. The first location is downstream of the second location, and the second location is downstream of the first impeller. In a second example, the compressor includes an impeller provided in a main refrigerant flow path, and a recirculation flow path provided between a first location and a second location along the main refrigerant flow path. In the second example, the recirculation flow path includes a recirculation volute. Further disclosed is a method for operating a centrifugal compressor. | 12-10-2015 |
20160138841 | COMPRESSOR WITH ROTOR COOLING PASSAGEWAY - A centrifugal compressor for a refrigeration system is disclosed. The centrifugal compressor includes an electric motor, which includes a rotor and a stator. The compressor further includes a housing enclosing the electric motor, a stator cooling passage provided within the housing, and a rotor cooling passageway provided within the housing. The rotor cooling passageway is independent of the stator cooling passageway. | 05-19-2016 |
Joost Brender A Brandis, Wilmington, NC US
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20120195771 | Water Pump for Use in Irrigation and for Other Purposes - The present invention addresses the need for a water pump that may be constructed from inexpensive materials available even in impoverished areas. The pump uses a simple rocking motion to pump water and can pump significant amounts of water from sources that otherwise could not be reached. In a preferred embodiment, the pump comprises three concrete chambers, a pumping platform adapted to rock in a see-saw fashion, and a plurality of valves to control the flow of water. The first two chambers contain diaphragms that, as a result of rocking the pumping platform, draw liquid into the chambers and force liquid from those chambers into the third chamber. Two valves selectively permit liquid to be drawn into the first and second chambers, and prevent the liquid from exiting the chambers and returning to the source. Third and fourth valves allow liquid to flow from the first and second chambers into the third chamber, and prevent the liquid in the third chamber from flowing back into the first or second chambers. | 08-02-2012 |
20120308411 | Water-Powered Pump for Use in Irrigation and for Other Purposes - The present invention is directed to a water pump that may be easily constructed from inexpensive parts and materials and that is powered by the water source from which the water to be pumped is drawn. In a preferred embodiment, two pairs of lever arms located on opposite sides of the pump are alternately filled with water from the source and then emptied causing the lever arms to alternately ascend and descend. As the lever arms ascend and descend, they alternately fill and then compress a pair of pistons causing water to be pumped to an outlet of the pump. Water from the emptied lever arms may preferably be returned to the source, thus minimizing any impact of the pump on the environment and downstream users of the water source. | 12-06-2012 |
Joost Brouckaert, Kortrijk BE
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20130022312 | Deep-Shallow Optical Radiation Filters - An optical coupler for processing radiation is described. The optical coupler comprises a first deep-shallow waveguide and a second deep-shallow waveguide for guiding radiation in a propagation direction. Each of the deep-shallow waveguides is a waveguide comprising a shallow etched portion and an unetched portion having a width substantially constant along the propagation direction. The width of the shallow etched portion is substantially larger than the width of the unetched portion. The shallow etched portion of the first deep-shallow waveguide and the shallow etched portion of the second deep-shallow waveguide are arranged sufficiently close for coupling radiation from the first deep-shallow waveguide to the second deep-shallow waveguide. | 01-24-2013 |
Joost Bruneel, Gullegem BE
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20160132032 | Energy Management System - An energy management system is disclosed having an in situ processing unit with a measuring unit capable of measuring a set of power related parameters over a main electricity cable. The system has a first processing unit capable of processing the power related parameters by applying a signature detection algorithm, for detecting an event relating to turning ON or OFF an electronic and/or electric appliance and for characterizing the event. The system also has means for transferring to a server a data packet having an output of said signature detection algorithm. The processing unit triggers the transfer of a data packet only in case such an event is detected. Also disclosed is a method for monitoring the use of electronic and/or electric appliances. | 05-12-2016 |
Joost De Pee, Veldhoven NL
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20090122284 | LITHOGRAPHIC APPARATUS HAVING AN ACTIVE DAMPING SUBASSEMBLY - A lithographic apparatus includes a projection system to project a patterned radiation beam onto a substrate, and a damping system to dampen a vibration of at least part of the projection system, the damping system including an interface damping mass and an active damping subsystem to dampen a vibration of at least part of the interface damping mass, the interface damping mass connected to the projection system, and the active damping subsystem connected to the interface damping mass, the active damping subsystem including a sensor to measure a position quantity of the interface damping mass and an actuator to exert a force on the interface damping mass based on a signal provided by the sensor. The damping system further includes an interface damping device connected to the interface damping mass and configured to damp a movement of the interface damping mass at an eigenfrequency of the interface damping mass. | 05-14-2009 |
20090147230 | Lithographic Apparatus and Device Manufacturing Method - A vibration damping arrangement for a lithographic apparatus includes a sensor arranged to, in use, detect a vibration of a projection system. An actuator is arranged to, in use, exert a force on a control unit of the projection system to convert an output signal of the sensor to an actuator input signal such that, during operation, the vibration of the projection system is mitigated by controlling the actuator by the input signal to exert the force to the projection system. | 06-11-2009 |
20090161085 | LITHOGRAPHIC APPARATUS HAVING ACOUSTIC RESONATOR - A lithographic apparatus may be provided with an acoustic resonator to dampen an acoustic vibration in the lithographic apparatus. The acoustic resonator may include a Helmholtz resonator. The helmholz resonator may be provided with an active element to provide active damping and/or altering a spring characteristic of the mass spring assembly formed by the resonator. The resonator may be provided at a slit in a shield between the patterning device stage and the projection system to suppress transfer of acoustical vibrations, caused by e.g. a movement of the patterning device stage, to the projection system. | 06-25-2009 |
20090195763 | LITHOGRAPHIC APPARATUS - A lithographic apparatus is arranged to transfer a pattern from a patterning device onto a substrate. The lithographic apparatus includes an acoustical sensor to measure a first acoustic vibration in a sensor measurement area in the lithographic apparatus. An actuator is provided to generate a second acoustic vibration in at least an area of the lithographic apparatus. Further, a control device is provided having a sensor input to receive a sensor signal of the acoustical sensor and an actuator output to provide an actuator drive signal to the actuator. The control device is arranged to drive the actuator so as to let the second acoustic vibration at least partly compensate in the area the first acoustic vibration. | 08-06-2009 |
20090207393 | Damping Arrangement, Active Damping System, Lithographic Apparatus, And Projection Assembly - An active damping system assembly is configured to dampen a vibration of at least part of a structure. The assembly includes a plurality of active dampers each including a sensor configured to measure a position quantity of an interface mass mounted on the structure; and an actuator configured to exert a force on the interface mass in dependency of a signal provided by the sensor, wherein each of the plurality of active damping systems is connected to the interface mass. The structure may be a projection system of a lithographic apparatus. | 08-20-2009 |
20100020525 | Cable Connection, Control System, and Method to Decrease the Passing on of Vibrations from a First Object to a Second Object - A cable connection between a first object and a second object includes a cable bundle of one or more cables having a certain length. One end of the cable bundle is fixed to the first object and another end of the bundle is fixed to the second object. A cable bundle holder configured to hold the cable bundle at a certain location along the length of the cable bundle, and a control system configured to control the position of the cable bundle holder with respect to the second object are presented. A control system for cable connection, and a method of reducing the transfer of vibrations from a first object to a second object via a cable connection are presented. | 01-28-2010 |
Joost Depicker, Wachtebeke BE
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20140306145 | CATALYSTS AND METHODS FOR ALCOHOL DEHYDRATION - Provided is a method for preparing a diaryl ether compound through the dehydration of an aromatic alcohol compound in the presence of a dehydration catalyst. The dehydration catalyst comprises an oxide of yttrium. | 10-16-2014 |
Joost Deseyne, Hooglede BE
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20100043907 | HEDDLE FRAME WITH REINFORCING PROFILE FOR A WEAVING MACHINE - Heddle frame having a transverse beam ( | 02-25-2010 |
Joost Dessing, Cv Hoofddorp NL
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20120000927 | MERCHANDISER - The present application and the resultant patent provide a merchandiser. The merchandiser may include an ambient compartment with at least one ambient product therein, a temperature controlled compartment with at least one temperature controlled product therein, and a rotary internal transport system within the temperature controlled compartment so as to dispense a temperature controlled product in response to an ambient product being placed therein. | 01-05-2012 |
Joost Duflou, Leuven BE
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20090050612 | Arrangement and method for the on-line monitoring of the quality of a laser process exerted on a workpiece - The invention relates to an arrangement ( | 02-26-2009 |
20090158805 | Asymmetric incremental sheet forming system - The present invention relates, in general, to sheet material forming technology and the forming of structures there from. The invention relates to incremental forming of sheet material ( | 06-25-2009 |
Joost Duvigneau, Winterswijk NL
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20150259493 | Polymer Foam Comprising a Polymer and Nanoparticles, and Nanoparticles for the Manufacture of Such Foam - A polymer foam is produced comprising a polymer and nanoparticles having a maximum dimension of 750 nm, which foam has cells with an average cell size of at most 1 μm and a cell density of at least 10 | 09-17-2015 |
Joost Erinkveld, Arnhem NL
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20150122585 | LIFT CHAIN TENSION RELIEVING DEVICES AND METHODS - Devices and methods to relieve lift chains from being maintained under constant, or nearly constant, tension are provided. | 05-07-2015 |
Joost Frederik, Eindhoven NL
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20100266174 | METHOD OF RETRIEVING DATA FROM A MEDICAL IMAGE DATA SET - The present invention discloses a method of retrieving a plurality of data slices from a medical image data set ( | 10-21-2010 |
Joost Ketsman, Oudernaarde BE
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20150225757 | PROCESS FOR INCREASING YIELD OF DEXTROSE PRODUCTION PROCESS, BY MEMBRANE TECHNOLOGY - The invention relates to a process for increasing the dextrose recovery from a dextrose containing solution. In particular, the invention relates to a process for increasing the dextrose yield of a starch hydrolysis process. The process comprises membrane filtration of a dextrose containing solution and an enzyme treatment of the retentate of the filtration. | 08-13-2015 |
Joost Ketsman, Oudenaarde BE
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20160000120 | SYRUP PURIFICATION BY CAPACITIVE DEIONIZATION - The invention relates to a process for purifying syrups. The process comprises removing charged components from the syrup by passing said syrup through a capacitive deionization cell. The present invention further relates to the use of capacitive deionization to recover charged components from syrups. In particular the syrups are mannose, fructose and sorbitol containing syrups. | 01-07-2016 |
Joost Kreijtz, Uden NL
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20110020391 | RECOMBINANT MODIFIED VACCINIA VIRUS ANKARA (MVA)-BASED VACCINE FOR THE AVIAN FLU - The present invention relates to the use of a recombinant modified vaccinia virus Ankara (MVA) comprising a heterologous nucleic acid for the production of a medicament in particular a vaccine, wherein the sequence of heterologous nucleic acid is from influenza A virus class H5 antigen. In a further aspect of the invention the invention relates to a recombinant modified vaccinia virus Ankara (MVA) comprising a heterologous nucleic acid, wherein (a) the heterologous nucleic acid is incorporated into a non-essential site within the genome of MVA, (b) the heterologous nucleic acid is under the control of a vaccinia virus promoter, or orthopoxvirus promoter, or poxvirus-specific promoter and, (c) the heterologous nucleic acid is selected from the group of nucleic acids encoding a gene or a part of a gene from an influenza A virus class H5. | 01-27-2011 |
Joost Lotters, Ruurlo NL
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20080290982 | TRANSFORMER CORE - A transformer core includes a stack of a plurality of planar core plates of a magnetically permeable material, which plates each consist of a first and a second sub-part that together enclose at least one opening. The sub-parts can be fitted together via contact faces that are located on either side of the opening and that extend obliquely with respect to the centerline of the core plate. The invention also relates to the use of the described transformer core in a Coriolis flowmeter with the Coriolis tube extending through the opening so as to induce a current in the tube. | 11-27-2008 |
Joost Manassen, Rehovot IL
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20100047683 | ELECTROCHEMICAL ENERGY STORAGE DEVICE - Apparatus and methodology subject matters relate to an improved electrochemical single or multi-cell energy storage device. Also, an outer casing may be provided as a pair of U-shaped shells, a single foil piece, or a tube-shaped structure which encases the internal electro chemical cell stack. The energy storage device and such casing when used advantageously exhibit low internal resistance, low ESR, a high voltage/capacity, and a low contact resistance between the internal stack and the outer casing. | 02-25-2010 |
Joost Melai, Enschede NL
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20090166753 | Semiconductor Device and Method of Manufacturing Such a Device - The invention relates to a semiconductor device ( | 07-02-2009 |
20090200577 | SEMICONDUCTOR DEVICE AND METHOD OF MANUFACTURING SUCH A DEVICE - The invention relates to a semiconductor device with a substrate ( | 08-13-2009 |
20090212394 | BIPOLAR TRANSISTOR AND METHOD OF FABRICATING THE SAME - The invention provides a bipolar transistor with an improved performance because of a reduced collector series resistance and a reduced collector to substrate capacitance. The bipolar transistor includes a protrusion ( | 08-27-2009 |
20100289022 | METHOD OF MANUFACTURING A SEMICONDUCTOR DEVICE AND SEMICONDUCTOR DEVICE OBTAINED WITH SUCH A METHOD - The invention relates to a method of manufacturing a semiconductor device ( | 11-18-2010 |
Joost Moelands, Breda NL
Joost Muller, New Delhi IN
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20120243092 | BARRIER LAYER AND A METHOD OF MANUFACTURING THE BARRIER LAYER - A barrier layer capable of preventing permeability of moisture, oxygen, other gases, solvents and volatile organic compounds is provided. The barrier layer includes a surface profile undulating in all directions. Further, the surface profile is characterized by the absence of non-undulating surface, straight lines and sharp edges. Further, the surface profile bends in reaction to at least one of thermal stress, mechanical stress, and load caused by deformation of an adjoining substrate or layer. This allows the barrier layer to stretch and shrink in all directions in a plane along the surface profile of the barrier layer and prevents cracking of the barrier layer. | 09-27-2012 |
Joost Neijssen, Ultrecht NL
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20140141000 | Bispecific EGFR/C-Met Antibodies - Bispecific EGFR/c-Met antibodies and methods of making and using the molecules. | 05-22-2014 |
20140255408 | Bispecific EGFR/C-Met Antibodies - Bispecific EGFR/c-Met antibodies and methods of making and using the molecules. | 09-11-2014 |
Joost Ortjens, Ehnen LU
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20150195870 | PTC HEATING DEVICE WITHOUT ELECTRONIC POWER CONTROL - Foil-based PTC heaters are self-regulating, i.e. do not need any electronic control unit (ECU) to limit the maximum heating current. In order to establish different heating power levels the present invention proposes to choose different PTC ratio/onset characteristics. In addition, the print design of the PTC ink can be adjusted accordingly. | 07-09-2015 |
Joost Poulus, Victoria AU
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20110020586 | Craft Fabric - A fabric material for use in craft activities, the fabric material comprising a textile substrate and a pressure sensitive adhesive carried by opposite surfaces of the substrate, whereby upon the application of pressure to one piece of the fabric material against another piece of the fabric material causes the adhesion of the pieces of fabric. | 01-27-2011 |
Joost Quirijnen, Raamsdonksveer NL
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20100282751 | SCREW CAP - The present invention relates to a screw cap ( | 11-11-2010 |
Joost Remijn, Amsterdam NL
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20160054137 | NAVIGATION DEVICE WITH ENHANCED WIDGETS AND APPLICATIONS - A navigation device is disclosed which has a navigation application and one or more third party application installed thereon. At least some of the third party applications are able to interact with the navigation application via an API to obtain data therefrom, and optionally provide data thereto. A home screen of the navigation device simultaneously displays a navigation widget associated with the navigation application, which displays navigation instructions provided by the navigation application to guide a user along a determined route, and at least one widget and/or shortcut associated with a third party application. | 02-25-2016 |
Joost Schreve, Palo Alto, CA US
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20080204317 | SYSTEM FOR AUTOMATIC GEO-TAGGING OF PHOTOS - The present invention contemplates a variety of improved techniques for geo-tagging of digital photo graphs. In some embodiments, this includes automatically updating photograph locations with a stored offset value. | 08-28-2008 |
Joost Schymkowitz, Meensel-Kiezem BE
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20140082769 | MOLECULES AND METHODS FOR INHIBITION AND DETECTION OF PROTEINS - The present application belongs to the field of functional peptides and more particularly to the field of controlled protein aggregation. The invention discloses molecules of a peptide structure as defined in the claims and methods of using such molecules for therapeutic applications and for diagnostic uses, as well as in other applications such as in the agbio field and in industrial biotechnology. The molecules can be used for curing and/or stabilizing infections such as bacterial, fungal and viral diseases, but are also useful in non-infectious human and veterinary diseases. The molecules can also be used for the detection of protein biomarkers and for the prognosis and diagnosis of a variety of diseases. | 03-20-2014 |
Joost Schymkowitz, Meensel-Kiezegem BE
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20090012275 | Means and methods for mediating protein interference - The invention belongs to the field of functional proteomics and, more particularly, to the field of protein aggregation. Described are methods for interfering with the function of a target protein and uses a non-naturally, user-designed molecule, designated as interferor, that has a specificity for a target protein and that induces aggregation upon contact with the target protein. The invention also discloses such interferer molecules and their use in therapeutic applications. | 01-08-2009 |
20100093001 | Means and methods for the production of amyloid oligomers - The present invention relates to the field of amyloid disorders, more particularly to the field of diseases where protein misfolding leads to the generation of insoluble amyloid fibers in tissues and organs. The invention provides methods for the production of soluble, toxic amyloid oligomers. The invention further provides assays using the amyloid oligomers to screen for molecules that interfere with the toxicity of the oligomers. | 04-15-2010 |
20120023624 | MEANS AND METHODS FOR MEDIATING PROTEIN INTERFERENCE - The present invention belongs to the field of functional proteomics and more particularly to the field of protein aggregation. The invention discloses a method for interfering with the function of a target protein and uses a non-naturally, user-designed molecule, designated as interferor, that has a specificity for a target protein and which induces aggregation upon contact with said target protein. The present invention also discloses such interferor molecules and their use in agrobiotech applications. | 01-26-2012 |
20120094864 | EXTRACELLULAR ALLOSTERIC INHIBITOR BINDING DOMAIN FROM A TYROSINE KINASE RECEPTOR - The present invention relates to an extracellular binding domain for an allosteric inhibitor, whereby said binding domain is derived from a single membrane span tyrosine kinase receptor. More specifically, the invention relates to an extracellular domain derived from a Fibroblast Growth Factor Receptor (FGFR). It further relates to the use of this domain for the identification of similar domains in the extracellular part of other tyrosine kinase receptors, and to a screening method for identification of a small compound allosteric inhibitor. | 04-19-2012 |
20140170239 | METHODS FOR SCREENING INHIBITORS OF TUMOR ASSOCIATED PROTEIN AGGREGATION - The disclosure relates to the fields of protein aggregation diseases including cancer. More specifically, it concerns a screening method for identifying compounds that inhibit or disrupt co-aggregation of one or more member proteins of a disease-related protein aggregome, in particular, a tumor-associated protein aggregome. Further, disclosed are agents and compounds identified by the screening method that can be applied to prevent or to treat protein aggregation diseases, such as cancer. | 06-19-2014 |
20140187741 | MEANS AND METHODS FOR MEDIATING PROTEIN INTERFERENCE - The present invention belongs to the field of functional proteomics and more particularly to the field of protein aggregation. The invention discloses a method for interfering with the function of a target protein and uses a non-naturally, user-designed molecule, designated as interferor, that has a specificity for a target protein and which induces aggregation upon contact with said target protein. The present invention also discloses such interferor molecules and their use in agrobiotech applications. | 07-03-2014 |
20150079066 | MEANS AND METHODS FOR GENERATING IMPROVED PROTEINS - The disclosure provides a general method for the production of protein variants with a reduced aggregation propensity without affecting the thermodynamic stability of the variant with respect to the wild-type protein. | 03-19-2015 |
20160115245 | SINGLE DOMAIN ANTIBODIES AGAINST SOD1 AND THEIR USE IN MEDICINE - The present application relates to the field of single-domain antibodies (also called nanobodies), more particularly single-domain antibodies against SOD1 protein isoforms. It also relates to the use of these nanobodies in medicine. Accordingly, methods to treat a disease using these nanobodies are provided herein. The single-domain antibodies are particularly envisaged for treatment of ALS. | 04-28-2016 |
Joost Van Der Neut, Delft NL
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20110130967 | METHOD OF CORRECTING AMPLITUDES IN VIRTUAL SOURCE IMAGING OF SEISMIC DATA - A method for imaging a subsurface formation using at least two seismic sources and receivers comprises: a) creating a wave field in the formation, b) obtaining a set of responses for each receiver and performing wave field separation on them, c) obtaining a virtual source signal for at least a first receiver k by cross-correlating at least part of the response of a second receiver m with at least part of the response of the first receiver k and summing the cross-correlated responses from the sources, making receiver k a virtual source, d) for each virtual source, estimating an amplitude radiation pattern by performing a transform of the response data, e) deconvolving at least one virtual source signal with at least part of the estimated radiation pattern for that receiver to produce an amplitude-corrected virtual source signal, and f) using that signal to create an image of the subsurface formation. | 06-02-2011 |
Joost Van Durme, Wakken BE
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20150079066 | MEANS AND METHODS FOR GENERATING IMPROVED PROTEINS - The disclosure provides a general method for the production of protein variants with a reduced aggregation propensity without affecting the thermodynamic stability of the variant with respect to the wild-type protein. | 03-19-2015 |
Joost Van Erkel, Apeldoorn NL
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20100108524 | BARRIER LAYER AND METHOD FOR MAKING THE SAME - The invention relates to a method for manufacturing an article comprising a barrier layer, the method comprising—providing an metallic or metalloid layer to a surface of a substrate by electro-deposition, using a plating liquid comprising an ionic liquid and metal ions or metalloid ions, which metal ions or metalloid ions are reduced and deposited to form the metallic or metalloid layer during the electro-deposition; and—preferably at least partially oxidising the metallic or metalloid layer. | 05-06-2010 |
20100133520 | METHOD FOR MANUFACTURING AN ELECTRODE - The present invention relates to a method for manufacturing an organic electronic device, comprising providing by electro-deposition an electrode to a surface of an electro-active material—the electro-active material comprising an organic electro-active compound—or providing said electrode to a surface of a substrate for said electro-active material, after which the electro-active material is applied to a surface of the electrode, wherein the electro-deposition comprises the use of a plating liquid comprising an ionic liquid and metal or metalloid ions which metal or metalloid ions are reduced and deposited to form the electrode. | 06-03-2010 |
Joost Van Erkel, Delft NL
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20130299428 | ANTIMICROBIAL MEMBRANE CONTAINING SILVER NANOPARTICLES - The invention is directed to an antimicrobial membrane, to a method for preparing said antimicrobial membrane, to a process of operating said antimicrobial membrane, and to uses of said antimicrobial membrane. | 11-14-2013 |
Joost Van Kappel, Sierre CH
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20120325381 | METHOD FOR MANUFACTURING 6XXX ALLOY MATERIALS FOR VACUUM CHAMBERS - The invention relates to a manufacturing process for an aluminum block of at least 250 mm thick designed for the manufacture of elements for vacuum chambers in which the following operations are carried out successively: an alloy block is cast by semi-continuous casting, the composition of this block in weight % being: Si 0.5-1.5; Mg: 0.5-1.5; Fe<0.3; Cu<0.2; Mn<0.8; Cr<0.10; Ti<0.15, other elements <0.05 each and <0.15 in total, the rest aluminum; solution heat treatment is performed at a temperature ranging between 450 and 560° C. directly on the cast block and optionally homogenized; the block that has undergone solution heat treatment is quenched at a cooling speed between the solution heat treatment temperature and 200° C. of at least 200° C./h; the block quenched and optionally stress-relieved is artificially aged. The blocks obtained in this way are advantageous for the production of vacuum chambers for the manufacture of integrated electronic circuits containing semiconductors, flat screens and/or photovoltaic panels. | 12-27-2012 |
Joost Van Osnabrugge, Tessenderlo BE
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20110097531 | BREATHING SHEET MATERIAL HAVING AN ADHESIVE COATING LAYER AND MANUFACTURING METHOD THEREFOR - The invention relates to a breathing adhesive sheet material comprising a sheet layer having apertures and an adhesive coating layer with apertures corresponding to at least part of the apertures of said sheet layer, provided on one side of said sheet layer having apertures, wherein said apertures in said adhesive coating layer constitute portions of a substantially continuous adhesive coating layer separated there from by remaining adhered to a protective sheet layer upon removal thereof. The invention also relates to a composite sheet material comprising such adhesive sheet material with a removable protective sheet layer provided to separate portions from the continuous adhesive layer upon separation thereof from the adhesive sheet material. The invention also relates to a method for manufacturing such an adhesive sheet material comprising the steps of applying a layer of uncured adhesive material to a sheet layer having apertures and a layer of protective sheet material, and submitting the sheet layer having apertures, the layer of protective sheet material and the layer of uncured adhesive material to a curing operation, thereby causing the layer of adhesive material to preferentially adhere to the sheet layer having apertures outside the apertures, and to adhere to the protective sheet layer at said apertures. | 04-28-2011 |
Joost Van Tooren, Muenchen DE
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20090027253 | Collision and conflict avoidance system for autonomous unmanned air vehicles (UAVs) - A collision and conflict avoidance system for autonomous unmanned air vehicles (UAVs) uses accessible on-board sensors to generate an image of the surrounding airspace. The situation thus established is analyzed for imminent conflicts (collisions, TCAS violations, airspace violations), and, if a probable conflict or collision is detected, a search for avoidance options is started, wherein the avoidance routes as far as possible comply with statutory air traffic regulations. By virtue of the on-board algorithm the system functions independently of a data link. By taking into account the TCAS zones, the remaining air traffic is not disturbed unnecessarily. The system makes it possible both to cover aspects critical for safety and to use more highly developed algorithms in order to take complicated boundary conditions into account when determining the avoidance course. | 01-29-2009 |
Joost Verhaagen, Amsterdam NL
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20100048678 | Nucleic acids and polypeptides that are useful in controlling neuronal regeneration - The present invention relates to methods for promoting regeneration response of peripheral and central nervous systems in mammals in need of such biological effects. The methods comprise altering the activity or steady state level of specific polypeptides that control regeneration of injured or degenerated neuronal cells. Preferably the activity or steady state level of specific polypeptides is altered by introducing nucleic acids to increase or decrease expressing of the polypeptides. These are useful in or suffering from neurodegenerative disorders. | 02-25-2010 |
20100273865 | Polypeptides involved in neuronal regeneration-associated gene expression - The present invention relates to methods for promoting regeneration response of peripheral and central nervous systems in mammals in need of such biological effects. The methods comprise altering the activity or steady state level of specific transcription factors that control regeneration of injured or degenerated neuronal cells. Preferably the activity or steady state level of specific transcription factors is altered by introducing nucleic acids to increase or decrease expressing of these transcription factors. These are useful in or suffering from neurodegenerative disorders. | 10-28-2010 |
Joost Vlassak, Lexington, MA US
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20100024534 | METHOD TO MEASURE THE ELASTIC MODULUS AND HARDNESS OF THIN FILM ON SUBSTRATE BY NANOINDENTATION - A method of measuring the elastic modulus and hardness of a thin film on substrate using nanoindentation technique is provided. The method includes calculating a series of experimental corrected stiffness and contact radius pairs associated with one or more presumed parameters and information obtained from a loading curve associated with the thin film and substrate. Also, the method includes calculating a series of theoretical corrected stiffness and contact radius pairs associated with the same one or more presumed parameters and information obtained from the loading curve associated with the thin film and substrate. Furthermore, the method includes using results obtained from the experimental and theoretical corrected stiffness and contact radius pairs to compute the elastic modulus and hardness of the film material. | 02-04-2010 |