Sander, US
Aaron J. Sander, North Lewisburg, OH US
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20150051083 | METHODS AND COMPOSITIONS FOR IDENTIFYING REPEATING SEQUENCES IN NUCLEIC ACIDS - Short Tandem Repeats are currently used by law enforcement and others, for example, for the identification of individuals by DNA matching. A method is described herein that uses WPD to classify and identify repeating sequences in nucleotide sequences from the position and frequency information contained within nucleotide sequences. This decomposition allows for the quick classification of nucleotide sequences (i.e., reads) into two different classes, including, for example, one class that contains sequencer reads that contain a repeat motif with non-repeat sequence on either flank, and another class that contains sequencer reads that do not contain any repeat sequence. | 02-19-2015 |
Andrew J. Sander, New Whiteland, IN US
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20130248535 | TANK WITH INTERNAL BAFFLE - A tank for holding liquid having internal partitions. The partitions have enlarged bottom ends fillable with liquid and restable on the bottom wall of the tank to limit sideways movement of the partitions. The partitions are mounted to the tank only above the liquid within the tank by a channel that loosely receives the top ends of the partition. | 09-26-2013 |
20140014664 | TANK WITH INTERNAL BAFFLE - A tank for holding liquid having internal partitions. The partitions have enlarged bottom ends fillable with liquid and restable on the bottom wall of the tank to limit sideways movement of the partitions. The partitions are mounted to the tank only above the liquid within the tank by a channel that loosely receives the top ends of the partition. | 01-16-2014 |
Chris Sander, Cambridge, MA US
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20110264420 | MODELS FOR COMBINATORIAL PERTURBATIONS OF LIVING BIOLOGICAL SYSTEMS - Techniques for modeling living biological systems include receiving constant values for multiple interaction factors w | 10-27-2011 |
Chris Sander, New York, MA US
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20130303383 | METHODS AND APPARATUS FOR PREDICTING PROTEIN STRUCTURE - The present invention relates to a method for predicting three-dimensional structure of a protein from its sequence. Three-dimensional structure may be determined by: (a) generating a multiple sequence alignment for a candidate protein having a known sequence; (b) identifying a covariance matrix between all pairs of sequence positions in the multiple sequence alignment; (c) inverting the covariance matrix and identifying predicted evolutionary constraints using a statistical model of the candidate protein; and (d) simulating folding of an extended chain structure of the candidate protein using the predicted constraints. | 11-14-2013 |
20130303387 | METHODS AND APPARATUS FOR PREDICTING PROTEIN STRUCTURE - The present invention relates to a method for predicting three-dimensional structure of a protein from its sequence. Three-dimensional structure may be determined by: (a) generating a multiple sequence alignment for a candidate protein having a known sequence; (b) identifying a covariance matrix between all pairs of sequence positions in the multiple sequence alignment; (c) inverting the covariance matrix and identifying predicted evolutionary constraints using a statistical model of the candidate protein; and (d) simulating folding of an extended chain structure of the candidate protein using the predicted constraints. | 11-14-2013 |
20130304432 | METHODS AND APPARATUS FOR PREDICTING PROTEIN STRUCTURE - The present invention relates to a method for predicting three-dimensional structure of a protein from its sequence. Three-dimensional structure may be determined by: (a) generating a multiple sequence alignment for a candidate protein having a known sequence; (b) identifying a covariance matrix between all pairs of sequence positions in the multiple sequence alignment; (c) inverting the covariance matrix and identifying predicted evolutionary constraints using a statistical model of the candidate protein; and (d) simulating folding of an extended chain structure of the candidate protein using the predicted constraints. | 11-14-2013 |
20150268248 | CELL SELECTIVE PROTEOME LABELING - The invention relates to a method for the Cell Type specific labeling with Amino acid Precursors (CTAP). In particular, the disclosed method permits the incorporation of stable isotope-labeled amino acids into the proteome of a vertebrate cell that has been engineered to express an exogenous enzyme that enables the cell to produce an essential amino acid from its amino acid substrate. The method employs stable isotope-labeled amino acid substrate/precursors from which essential amino acids bearing the label are generated. The labeled amino acids generated by the transgenic cell not only supports growth but specifically labels proteins of the transgenic cell. Furthermore, the use of different populations of cells expressing different exogenous amino acid-producing enzymes permits differential labeling of the proteomes of the individual cell populations in multicellular environments. | 09-24-2015 |
20150342960 | DRUG COMBINATIONS FOR TREATMENT OF MELANOMA AND OTHER CANCERS - Presented herein are methods of treating cancer, for example, RAFi-resistant melanoma, using a combination of a bromodomain inhibitor such as JQ1, together with either a MEK inhibitor (e.g., MEKi) or a BRAF inhibitor (e.g., RAFi). These combinations were identified from candidate combinations produced by a cell type-specific, quantitative network model of signaling in cells (e.g., melanoma) to predict cellular response to untested combinatorial perturbations. | 12-03-2015 |
20150345047 | SYSTEMS AND METHODS FOR IDENTIFYING DRUG COMBINATIONS FOR REDUCED DRUG RESISTANCE IN CANCER TREATMENT - Methods and systems are presented herein for creating and using cell type-specific, quantitative network models of signaling in cells, such as melanoma, to predict cellular response to untested combinational perturbations. The methods involve performing a set of perturbation experiments with cells of a particular type to produce phosphoproteomic and/or phenotypic profiles for the cells; automatically extracting prior pathway information from one or more known databases to build a qualitative prior model; building a signaling pathway model from (i) the phosphoproteomic and/or phenotypic profiles produced from the perturbation experiments and (ii) the qualitative prior model from the known database(s); and performing in silico perturbations using the signaling pathway model to predict responses to a set of perturbation conditions not yet experimentally tested, and identifying one or more candidate drug combinations from the predicted responses. | 12-03-2015 |
Colt Sander, Alvo, NE US
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20100148458 | Medical Ventilator Cart - A medical ventilator cart, for use in hospitals or other medical settings, stores and transports various components of a ventilator system, such as a Breath Delivery Unit, a display monitor, and a compressor. First and second platforms are suspended above a base of the cart and allow the various ventilator cart components to be separately and independently placed on and removed from the cart without the need to move or rearrange any of the other ventilator components. One version of the cart provides an additional compressor platform attached to the base for mounting a compressor below the first platform. | 06-17-2010 |
Cory M. Sander, Omaha, NE US
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20100310714 | L-LYSINE-CONTAINING FEED ADDITIVES - The invention relates to relatively light and thermally stable granulated, fermentation-broth-based animal feed additives having a high content of L-lysine and to low-loss methods for their production from broths obtained by fermentation. | 12-09-2010 |
20140302202 | L-Lysine-containing feed additives - The invention relates to relatively light and thermally stable granulated, fermentation-broth-based animal feed additives having a high content of L-lysine and to low-loss methods for their production from broths obtained by fermentation. | 10-09-2014 |
David Sander, Rockville, MD US
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20130193307 | SYSTEM, METHOD, AND DEVICE FOR SUPPRESSION OF DARK CURRENT - A method, system and device for reducing dark current, by clamping the voltage across the photodiode to about zero using local storage of charge, in an array of pixel cells in which each pixel cell has a photodiode configured to receive light and generate a photocharge during an integration period. | 08-01-2013 |
David J. Sander, South Winders, CT US
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20130343066 | LASER INSTRUMENTATION BRACKET - An exemplary laser instrumentation bracket includes a support structure providing a recess configured to receive a collar of a laser housing. The laser housing has a main body extending axially through an aperture of the support structure when the recess receives the collar. | 12-26-2013 |
David J. Sander, South Windsor, CT US
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20140248146 | ATTACHMENT APPARATUS FOR CERAMIC MATRIX COMPOSITE MATERIALS - A first ceramic matrix composite structure having a first flange with a first aperture, and a second structure having a second flange with a second aperture are clamped together by a fastener and spring assembly. The second flange is in contact with the first flange and the apertures of the first and second flanges align with each other. A threaded fastener having a thermal expansion rate that is different than the thermal expansion rate of at least one of the first ceramic matrix composite structure and second structure extends through the aligned apertures. The fastener includes a bolt, a nut, and a spring assembly that maintains a constant clamping pressure irrespective of the thermal expansion differences between the bolt and the first ceramic matrix composite structure and second structure. | 09-04-2014 |
20140314547 | ATTACHMENT APPARATUS FOR CERAMIC MATRIX COMPOSITE MATERIALS - A first ceramic matrix composite structure having a first flange with a first aperture, and a second structure having a second flange with a second aperture are clamped together by a fastener and spring assembly. The second flange is in contact with the first flange and the apertures of the first and second flanges align with each other. A threaded fastener having a thermal expansion rate that is different than the thermal expansion rate of at least one of the first ceramic matrix composite structure and second structure extends through the aligned apertures. The fastener includes a bolt, a nut, and a spring assembly that maintains a constant clamping pressure irrespective of the thermal expansion differences between the bolt and the first ceramic matrix composite structure and second structure. | 10-23-2014 |
20160003104 | GAS TURBINE ENGINE ATTACHMENT STRUCTURE AND METHOD THEREFOR - An attachment structure for a gas turbine engine includes a frame that has a first annular case. A second annular case extends around the frame. The first annular case and the second annular case include a plurality of interlocks. Each of the interlocks includes a first member mounted on one of the first annular case or the second annular case and a corresponding second member mounted on the other of the first annular case or the second case. The first member is received in the second member such that the plurality of interlocks restricts relative circumferential and axial movement between the first annular case and the second annular case. | 01-07-2016 |
David R. Sander, Liberty Township, OH US
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20130306826 | HEIGHT ADJUSTMENT MECHANISM FOR JUVENILE PRODUCT - A juvenile product height adjustment mechanism which allows for easy, secure adjustment by a caregiver is comprised of a rotatable knob received within a sliding channel and rotatably but securely attached to a slider. | 11-21-2013 |
20140049081 | ADJUSTMENT MECHANISM FOR JUVENILE PRODUCT - A juvenile product adjustment mechanism which allows for easy, secure adjustment by a caregiver is comprised of a rotatable key received within a sliding channel operated by a resiliently biased push button. | 02-20-2014 |
Elizabeth Sander, Memphis, TN US
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20140188238 | BALL AND SOCKET IMPLANTS FOR CORRECTION OF HAMMER TOES AND CLAW TOES - A toe bone implant for correction of toe bone deformities is provided. The toe bone implant includes a first portion having a socket portion. The toe bone implant also includes a second portion having a ball portion operatively connected to the socket portion. The toe bone implant is implanted in a joint such that the ball portion is configured to rotate a predetermined amount respective to the socket portion. | 07-03-2014 |
20140277538 | REVISION IMPLANT AUGMENTS, SYSTEMS, AND METHODS - In some embodiments, a surgical method includes creating an incision in a patient, exposing a multi-component prosthesis implanted in a patient, disassembling at least one component of the multi-component prosthesis, and coupling a first revision implant component to a first component of the multi-component prosthesis. The revision implant component has a body including at least one of a projection or an opening that is complementary to a feature of the first component of the multi-component prosthesis for coupling the revision implant component to the first component of the multi-component prosthesis. | 09-18-2014 |
20150088266 | BALL AND SOCKET IMPLANTS FOR CORRECTION OF HAMMER TOES AND CLAW TOES - A toe bone implant for correction of toe bone deformities is provided. The toe bone implant includes a first portion having a socket portion. The toe bone implant also includes a second portion having a ball portion operatively connected to the socket portion. The toe bone implant is implanted in a joint such that the ball portion is configured to rotate a predetermined amount respective to the socket portion. | 03-26-2015 |
Elizabeth J. Sander, Memphis, TN US
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20160051267 | GEARED INSTRUMENT FOR TIBIAL STEM REAMING OR REMOVAL - The present subject matter relates to a geared instrument. The geared instrument is configured to translate rotation about a first axis to rotation about a second axis. The geared instrument comprises a handle configured to rotate about the first axis. A translation gear is configured to couple to the handle. A stem is coupled to the translation gear and rotates in unison with the translation gear. The translation gear is configured to translate the rotation of the handle about the first axis to rotation of the stem about the second axis. The stem is configured to couple to a modular head. | 02-25-2016 |
20160051369 | REVISION IMPLANT AUGMENTS, SYSTEMS, AND METHODS - A revision implant component comprising a body having a plurality of screw holes and a tapered head configured to engage a talar dome component of a multi-component ankle prosthesis. A surgical method is disclosed which includes creating an incision in a patient, exposing a multi-component ankle prosthesis implanted in a patient, disassembling at least one component of the multi-component ankle prosthesis, affixing a revision implant component to non-damaged bone using screws, and coupling the revision implant component to a talar dome of the multi-component ankle prosthesis. | 02-25-2016 |
Emily Ann Sander, Chicago, IL US
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20100306708 | SYSTEMS AND METHODS FOR HANDLING PROFILES IN A COMMUNITY - Systems and methods for handling profiles in a community are provided. A profile hub-and-spoke arrangement may be provided which includes a profile representation associated with a user as the hub and one or more media asset representations as one or more spokes. The media asset representations that are included in the hub-and-spoke arrangement may match preferences of the user. As a cursor is positioned over various items of the hub-and-spoke arrangement, a window of information corresponding to the item may be provided. A selection of the item may be received and a new hub-and-spoke arrangement may be generated and displayed to correspond to the selected item. A similar media asset hub-and-spoke arrangement may be provided which includes a media asset representation as the hub and one or more community member representations as one or more spokes. | 12-02-2010 |
Eric J. Sander, Mendota Heights, MN US
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20100100426 | AGENT MANAGEMENT SYSTEM - An automated process for processing application data related to agent on-boarding in a money transfer system includes proforma subprocessing to pre-qualify the application data, analysis subprocessing to analyze the application data, set-up subprocessing to set up agents on the money transfer system and training subprocessing to train the agents on services provided by the money transfer system. Each of the subprocesses accepts an administrator input in response to the application data. In response to the administrator input, each of the subprocesses has an outcome that is one of forwarding the data, denying the data, notifying an originator of the application data and requesting additional data. | 04-22-2010 |
20120036071 | VERIFICATION METHODS FOR FRAUD PREVENTION IN MONEY TRANSFER RECEIVE TRANSACTIONS - A computer system is operated to prevent fraud in a money transfer receive transaction. A send transaction request is received from a sender for a money transfer including a send amount. The sender is prompted to select one or more security inputs to be supplied by a receiver for redemption of the money transfer. A send transaction record is stored with the selected one or more security inputs in a server. A receive transaction request is then received from the receiver. The receiver is prompted for the one or more security inputs set for redemption of the money transfer, and the provided one or more security inputs from the receiver are received. The received one or more security inputs are authenticated, and release of funds in the send amount is authorized if the received one or more security inputs are authenticated. | 02-09-2012 |
20130073457 | AGENT ACCESS PORTAL TO MONEY TRANSFER SYSTEM - A method for operating a computer-based processing system to provide money transfer services though user interfaces including agent portals. A plurality of user-specific and/or terminal-specific profiles including money transfer-related services available to a user and/or terminal are stored. Requests to provide money transfer-related services are received from a plurality of terminals operated by users at locations. Profiles associated with the one or more of the users operating the terminals and the locations of the terminals from which the money transfer-related service requests are received are determined. Portals including tabs linking to available money transfer-related services associated with the determined profiles are provided. | 03-21-2013 |
20140207664 | AGENT MANAGEMENT SYSTEM - An automated process for processing application data related to agent on-boarding in a money transfer system includes proforma subprocessing to pre-qualify the application data, analysis subprocessing to analyze the application data, set-up subprocessing to set up agents on the money transfer system and training subprocessing to train the agents on services provided by the money transfer system. Each of the subprocesses accepts an administrator input in response to the application data. In response to the administrator input, each of the subprocesses has an outcome that is one of forwarding the data, denying the data, notifying an originator of the application data and requesting additional data. | 07-24-2014 |
20140289120 | VERIFICATION METHODS FOR FRAUD PREVENTION IN MONEY TRANSFER RECEIVE TRANSACTIONS - A computer system is operated to prevent fraud in a money transfer receive transaction. A send transaction request is received from a sender for a money transfer including a send amount. The sender is prompted to select one or more security inputs to be supplied by a receiver for redemption of the money transfer. A send transaction record is stored with the selected one or more security inputs in a server. A receive transaction request is then received from the receiver. The receiver is prompted for the one or more security inputs set for redemption of the money transfer, and the provided one or more security inputs from the receiver are received. The received one or more security inputs are authenticated, and release of funds in the send amount is authorized if the received one or more security inputs are authenticated. | 09-25-2014 |
Eric James Sander, Mendota Heights, MN US
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20110155799 | Retail Sale Money Transfer System - A system and method for performing money transfer send transactions uses a plurality of tokens for retail sale, each token representing a specific money transfer purpose and having a send transaction identifier. A computer system is connectable to receive from a point of sale terminal data representing a send transaction identifier of at least one token and creating a send transaction record linked to the token's send transaction identifier. A control module executing in the computer system presents to the sender a completion interface that includes elements reflecting the specific money transfer purpose and fields for receiving send transaction information comprising: sender identification information; recipient identification information; and message options related to the specific money transfer purpose. In response to receipt of sufficient information entered at the completion interface, a memory for stores an active, funded send transaction record in the computer system including the message options. | 06-30-2011 |
George H. Sander, Palmyra, VA US
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20090082903 | Automated stacking system for wood products - Provided is a system for cutting and sorting of engineered wood products. Using appropriate software, a designer may model an entire house's structural frame. The dimensions and labeling for individual members of the structure are extracted from the model and captured by the software. The software may batch and optimize the products to be cut on the saw and develop sawing control instructions. The instructions are used by the saw to process the parts according to the house structure design. As the parts are processed by the saw, they are discharged and sent to an outfeed system that will stack the engineered wood products according to the parameters defined by the workstation operator. The system can handle the multiple lengths and widths of engineered wood parts from the saw and stack them in the order the software may specify. | 03-26-2009 |
20100305735 | METHOD FOR AUTOMATED STACKING OF WOOD PRODUCTS - The disclosure relates to a computer-implemented method for stacking wood products. In some embodiments, the disclosure the steps of designing at least two types of engineered wood products via a software application; producing the at least two types of engineered wood products based on the designs utilizing a saw in conjunction with the software application; designating, via the software application, at least two bins to hold the at least two different types of engineered wood products; selecting a first bin for depositing a first type of engineered wood product; selecting a second bin for depositing a second type of engineered wood product; automatically placing the first type of engineered wood product into the first bin; and automatically placing the second type of engineered wood product into the second bin. The at least two types of engineered wood products are at least two of: panels, I-joists, headers and dimensional lumber. | 12-02-2010 |
Guillermo Sander, Ridgewood, NJ US
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20150359502 | SYSTEM AND METHOD FOR DETERMINING X-RAY EXPOSURE PARAMETERS - In accordance with one aspect of the present system, a dual energy X-ray imaging system includes a communication module configured to receive a pre-shot image from a detection circuitry and receive one or more pre-shot parameters from a source controller of the dual energy X-ray imaging system. The dual energy X-ray imaging system further includes an analysis module configured to determine one or more image characteristics of the pre-shot image. The dual energy X-ray imaging system further includes a determination module configured to calculate a first and a second set of main-shot parameters based on the one or more pre-shot parameters and the one or more image characteristics of the pre-shot image. The determination module is further configured to send the one or more main-shot parameters to the source controller of the dual energy X-ray imaging system. | 12-17-2015 |
Ian Sander, South Bend, IN US
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20150047724 | FLUID MANIFOLD - A fluid manifold that consistently and reliably delivers fluids to one or more subject interfaces is provided. A branched pattern of bifurcated lumina carrying the fluid from a source to the outlets in each subject interface provides substantially equal amounts of fluid to each subject interface, thereby reducing the risk of over- or under-delivery of the fluid. A fluid-scavenging system is also included. A plurality of exhaust inlets in the interior of the subject interfaces is connected to a source of negative pressure through a channel and exhaust port to collect fluid before it can escape the subject interface, thereby reducing the risk of escaping fluid reaching the atmosphere. | 02-19-2015 |
Jeffrey Duncan Sander, Warwick, NY US
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20120143195 | DRIVE TOOL HAVING AN ANGLED CONNECTOR - A tool connecting device has a first member extending along a first axis and has an internal cavity adjacent a first end and a threaded outer surface. A second member extends along a second axis and has a tool at a first end and a joint element at a second end. The joint element is pivotally mounted in the cavity of the first member. The second member has an angled surface intermediate the first and second ends. The angled surface is angled outwardly in a direction from the second to the first end. A sleeve is provided which has a threaded inner bore mounted on the threaded outer surface of the first member and is capable of moving along the first axis. The sleeve has a tapered leading end for contacting the angled surface of the second member. The sleeve is movable on the first member to multiple positions along the first axis each position allowing an angle between the second axis and the first axis to be limited to any angle between 0 degrees and approximately 45 degrees. | 06-07-2012 |
Jeffrey Duncan Sander, Liberty Township, OH US
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20140031945 | CEMENT PRESSURIZING GLENOID - A prosthetic glenoid component has a body having a concave bearing surface and a convex glenoid contacting surface. First and second pegs extend outwardly from adjacent respective first and second ends of the bone contacting surface of the body, the first and second pegs have portions with a first diameter at the bone contacting surface extending for a first length and a second diameter extending from the first diameter for a second length, the first diameter larger than the second diameter. A third peg extends outwardly from the bone contacting surface intermediate the first and second pegs. The third peg has a third diameter greater than the second diameter portion of the first and second pegs and a third length greater than the first length of the first diameter portion of the first and second pegs. The third length is less than the sum of the first and second lengths. | 01-30-2014 |
Jeffry D. Sander, Ankeny, IA US
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20140274812 | Methods of Transcription Activator Like Effector Assembly - The disclosure describes methods that include providing a first nucleic acid having a sequence encoding a first set comprising one or more transcription activator-like effector (TALE) repeat domains and/or one or more portions of one or more TALE repeat domains; contacting the first nucleic acid with a first enzyme, wherein the first enzyme creates a first ligatable end; providing a second nucleic acid having a sequence encoding a second set comprising one or more TALE repeat domains and/or one or more portions of one or more TALE repeat domains; contacting the second nucleic acid with a second enzyme, wherein the second enzyme creates a second ligatable end, and wherein the first and second ligatable ends are compatible; and ligating the first and second nucleic acids through the first and second ligatable ends to produce a first ligated nucleic acid, wherein the first ligated nucleic acid is linked to a solid support, and wherein the first ligated nucleic acid encodes a polypeptide comprising said first and second sets. | 09-18-2014 |
Jeffry D. Sander, Woburn, MA US
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20120178647 | ENGINEERING OF ZINC FINGER ARRAYS BY CONTEXT-DEPENDENT ASSEMBLY - A method of designing a multi-zinc-finger polypeptide predicted to bind to a sequence of interest that has at least three subsites includes the steps of: a) providing a nucleotide sequence of interest having first, second, and third consecutive subsites, wherein each of the first and third subsites are adjacent to the second subsite; b) identifying first and second adjacent zinc finger polypeptide sequences previously shown to bind to the first and second subsites in the context of a multi-zinc finger polypeptide; c) identifying a third zinc finger polypeptide previously shown to bind to a third subsite adjacent to the second subsite when present in the context of a multi-zinc finger polypeptide adjacent to the second zinc finger polypeptide; and d) combining the first, second, and third zinc finger polypeptide sequences in linear order, thereby designing a multi-zinc finger polypeptide predicted to bind to the sequence of interest. | 07-12-2012 |
Jeffry D. Sander, Ames, IA US
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20140295557 | Using Truncated Guide RNAs (tru-gRNAs) to Increase Specificity for RNA-Guided Genome Editing - Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems, using truncated guide RNAs (tru-gRNAs). | 10-02-2014 |
20160024523 | Using Truncated Guide RNAs (tru-gRNAs) to Increase Specificity for RNA-Guided Genome Editing - CRISPR-Cas genome editing uses a guide RNA, which includes both a complementarity region, which binds the target DNA by base-pairing, and a Cas9-binding region, to direct a Cas9 nuclease to a target DNA. Further disclosed are methods for increasing specificity of RNA-guided genome editing using CRISPR/Cas9 systems by using truncated guide RNAs (tru-gRNAs). | 01-28-2016 |
20160024524 | Increasing Specificity for RNA-Guided Genome Editing - Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems. | 01-28-2016 |
Lane C. Sander, Gaithersburg, MD US
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20090043042 | Covalently Immobilized Fluorinated Carboxylic Acid Stationary Phase For Liquid Chromatography - A stationary phase for a liquid chromatograph and process for making is provided. The stationary phase material may have a modified base substrate and a fluorinated carboxylic acid covalently bonded thereto through an amide or ester bond. The stationary phase may have a substantially consistent shape selectivity characteristic with an α | 02-12-2009 |
Leonard M. Sander, Ann Arbor, MI US
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20120232225 | SYNTHESIS AND ISOLATION OF DENDRIMER SYSTEMS - The present invention relates to novel methods of synthesis and isolation of dendrimer systems. In particular, the present invention is directed to novel dendrimer conjugates with defined and limited numbers of ligand conjugates and high levels of structural uniformity, methods of synthesizing the same, compositions comprising the conjugates, as well systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). | 09-13-2012 |
Melissa Suzanne Sander, Schenectady, NY US
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20100155252 | MEMBRANE STRUCTURE AND METHOD OF MAKING - A membrane structure is provided. The membrane structure includes a first layer having a plurality of interconnected pores; and a second layer disposed on the first layer. The second layer has a plurality of unconnected pores. Each of the unconnected pores is in fluid communication with at least one of the interconnected pores of the first layer. A method of making a membrane structure is provided. The method includes the steps of providing a first layer having a plurality of interconnected pores; and disposing a second layer on the first layer. Disposing a second layer includes depositing a conducting layer on the first layer; and anodizing the conducting layer to convert the conducting layer into a porous layer. | 06-24-2010 |
Melissa Suzanne Sander, Denver, CO US
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20100108241 | MEMBRANE STRUCTURE AND METHOD OF MAKING - A membrane structure is provided. The membrane structure includes a first layer having a plurality of pores; and a second layer disposed on the first layer. The second layer has a plurality of unconnected pores. At least a portion of the plurality of unconnected pores of the second layer is at least partially filled with a filler such that the first layer is substantially free of the filler. At least a portion of the plurality of unconnected pores of the second layer is in fluid communication with at least one of the pores of the first layer. A method of making a membrane structure is provided. The method includes the steps of providing a first layer having a plurality of interconnected pores; disposing a second layer on the first layer, and filling at least a portion of the unconnected pores of the second layer with a filler such that the first layer is substantially free of the filler. Disposing a second layer includes depositing a metal layer on the first layer; and anodizing the metal layer to convert the metal layer into porous oxide layer. | 05-06-2010 |
Michael Sander US
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20110124910 | CRYSTALLINE POTASSIUM SALT OF LIPOXIN A4 ANALOGS - This invention is directed to the crystalline potassium salt of a lipoxin A | 05-26-2011 |
Michael Sander, Denville, NJ US
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20120064211 | MULTIPURPOSE CHEF BASKET - A chef basket is disclosed. The basket includes a ring, a plurality of overhangs, the overhangs coupled to the ring and juxtaposed over each neighboring overhang, a plurality of interlocking wires forming a straining surface, the straining surface coupled to the ring; and at least two handles, the at least two handles rotatably coupled to the ring, wherein at least five different reversible configurations or orientations, including a collapsed configuration, a first standing configuration, a second standing configuration, a first configuration, and a second configuration, are formed. | 03-15-2012 |
Michael Sander, Pittsford, NY US
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20130033397 | METHODS FOR RECEIVING GPS INDOORS WITH HIGH PRECISION AND DEVICES THEREOF - A method, non-transitory computer readable medium, and apparatus that determines a GPS location includes obtaining assisted GPS data of locations of a plurality of GPS satellites, current time, and initial location data of the receiver computing device. A GPS signal from one or more of the plurality of GPS satellites within a frequency range and time range is acquired based on the obtained assisted GPS data, current time, and initial location data of the receiver computing device. The one or more acquired GPS signals are integrated over a frame period of two or more seconds. A GPS location for the receiver computing device is determined based on the one or more integrated GPS signals. | 02-07-2013 |
Paul Sander, Jacksonville, FL US
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20150210053 | Superhydrophobic, Oleophobic and Ice-Phobic Fabrics - Fabrics that have been treated to create superhydrophobic, oleophobic and/or ice-phobic performance are manufactured or assembled in specific conforming shapes so they can be positioned on or pulled over and around certain objects for the purpose of making those objects superhydrophobic, oleophobic and/or ice-phobic so they are self-cleaning, water proof, ice-resistant, oil-resistant, corrosion barriers, etc. | 07-30-2015 |
Raymond J. Sander, Mount Vernon, OH US
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20090011848 | Releasable and Interchangeable Connections For Golf Club Heads and Shafts - Golf club heads are releasably engaged with shafts so that the club heads and shafts can be readily interchanged and/or so that the shaft position with respect to the club head can be readily changed. Assemblies for connecting the club head and shaft may include: (a) a shaft engaging member including a rotation-inhibiting structure; (b) a club head engaging member including a shaft-receiving chamber and a retaining structure for engaging the rotation-inhibiting structure; and (c) a securing system for releasably securing the shaft engaging member with respect to the club head engaging member. The club head and shaft may be changed by releasing the securing system and exchanging the original parts with different parts. Furthermore, the shaft may be bent or otherwise extend at an angle from the shaft engaging member so as to allow adjustment of the shaft position with respect to the club head. | 01-08-2009 |
20100216563 | SYSTEM FOR DETERMINING PERFORMANCE CHARACTERISTICS OF A GOLF SWING - An instrumented golf club system and methods are disclosed. A variety of golf swing parameters are measured by the instrumented golf club and wirelessly transmitted to a portable computer device. The portable computer device generates a user interface that displays the golf swing parameters against preferred golf swing parameters. The instrumented golf club system allows a golfer to receive feedback in real time while playing golf. | 08-26-2010 |
20100216564 | SYSTEM FOR DETERMINING PERFORMANCE CHARACTERISTICS OF A GOLF SWING - An instrumented golf club system and methods are disclosed. A variety of golf swing parameters are measured by the instrumented golf club and wirelessly transmitted to a portable computer device. The portable computer device generates a user interface that displays the golf swing parameters against preferred golf swing parameters. The instrumented golf club system allows a golfer to receive feedback in real time while playing golf. | 08-26-2010 |
20100216565 | SYSTEM FOR DETERMINING PERFORMANCE CHARACTERISTICS OF A GOLF SWING - An instrumented golf club system and methods are disclosed. A variety of golf swing parameters are measured by the instrumented golf club and wirelessly transmitted to a portable computer device. The portable computer device generates a user interface that displays the golf swing parameters against preferred golf swing parameters. The instrumented golf club system allows a golfer to receive feedback in real time while playing golf | 08-26-2010 |
Reinhard E. Sander, Wauwatosa, WI US
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20090026022 | WHEEL CHOCK SYSTEM - A wheel restraint for restraining a vehicle at a loading dock includes various features such as, a wheel chock supported by a spring loaded articulated arm with a spring that can be selectively tightened or released, a sensor that detects whether the chock is solidly against a base plate or floor, a bi-directional pivotal joint between the articulated arm and the wheel chock to ensure that the chock can sit squarely on a mating base plate, a wheel chock that meshes with a hydraulically actuated base plate, pivotal or otherwise movable backstops that prevent a wheel chock from sliding out of position, and a base plate cleaning system. The cleaning system might include a vehicle-actuated brush, fluid spray nozzles, electric heater and removable cover plates. | 01-29-2009 |
20090194375 | MANUAL WHEEL CHOCKS WITH AUTOMATIC POSITIVE LOCKING - A wheel restraint includes a wheel chock that is manually movable between a retracted position clear of a wheel of a vehicle at a loading dock and an operative position to block the path of the wheel. In the retracted position, the chock can be manually moved freely along a track that is mounted to a driveway of the dock. When the chock is manually moved from its retracted position to its operative position, a locking feature automatically restricts the movement of the chock relative to the track. When the chock is manually moved back to its retracted position, the locking feature automatically disengages. Although the wheel chock is connected to a track, most of the force exerted by the wheel against the chock is transmitted directly from the chock to the driveway. | 08-06-2009 |
20100260585 | FLUSH-MOUNTED VEHICLE RESTRAINTS - A vehicle restraint installed within a pit underneath a dock leveler of a loading dock platform includes a single actuator that both extends and raises a barrier into engagement with a vehicle's ICC bar. When the barrier is in a retracted, stored position, the barrier is underneath the dock leveler and behind a front face of the loading dock platform. To engage the vehicle's ICC bar, the single actuator extends to first push the barrier along a first track to an intermediate position. That same actuator then pushes the barrier along a second track to a raised, operative position where the barrier engages and captures the vehicle's ICC bar. A spring coupled to the actuator provides the barrier with freedom to float along the second track to accommodate similar incidental movement of the ICC bar as the vehicle is serviced at the dock. | 10-14-2010 |
20130037356 | WHEEL CHOCK SYSTEM - Vehicle restraint systems are disclosed herein. An example vehicle restraint system includes a base to be positioned adjacent a loading dock and a wheel chock to be positioned on the base. An actuator is coupled to the base and moves the base relative to a wall of the loading dock in a linear direction between a release position and a holding position when the wheel chock is coupled to the base. In the release position, the wheel chock disengages from a wheel of a vehicle positioned at the loading dock. In the holding position, the wheel chock frictionally engages the wheel of the vehicle to restrict movement of the wheel away from the loading dock. | 02-14-2013 |
Sanna Sander, North Potomac, MD US
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20100120896 | Once-A-Day RNA-Polymerase inhibiting and elongation factor G (EF-G) inhibiting antibiotic pharmaceutical product, formulation thereof, and use thereof in treating infection caused by methicillin-resistant staphylococcus aureus - Disclosed are once-a-day antibiotic products for treating Methicillin-Resistant | 05-13-2010 |
Tamara Sander, Mazomanie, WI US
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20130149697 | DETECTION OF HPV - The present invention provides compositions and methods for the detection and characterization of HPV sequences. More particularly, the present invention provides compositions, methods and kits for using invasive cleavage structure assays (e.g. the INVADER assay) to screen nucleic acid samples, e.g., from patients, for the presence of any one of a collection of HPV sequences. The present invention also provides compositions, methods and kits for screening sets of HPV sequences in a single reaction container. | 06-13-2013 |
Thomas Sander, Virginia Beach, VA US
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20150150607 | Cortical Bone Pin - A pin made of cortical bone may be inserted into adjoining bones of a toe to align and secure the bones. The pin may have barbs to prevent migration of the pin. The pin may include a shoulder to further prevent migration of the pin from the bones, to increase the strength of the pin, and to increase the surface area between the bone pin and the host bone. The pin may further include flattened portions on its circumference to aide in rotating the pin during insertion. The pin may be treated to reduce brittleness. | 06-04-2015 |
Thomas Sander, Gainesville, FL US
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20090018655 | Composite Implant for Surgical Repair - Disclosed are biocompatible implants that combine a scaffold material for supporting long term repair of a soft tissue with an elongated member such as a suture for aiding in placement of the scaffold during a surgical procedure as well as for immediate mechanical reinforcement of a repair site. The components of an implant are combined such that a longitudinal load placed upon a composite structure can be borne primarily by the elongated member and the scaffold material is isolated from the longitudinal load. Thus, the scaffold material of a composite can be protected from damage due to applied loads and stresses during and following a surgical procedure. | 01-15-2009 |
20090196898 | STABILIZED, STERILIZED COLLAGEN SCAFFOLDS WITH ACTIVE ADJUNCTS ATTACHED - Bioimplants and methods of making the bioimplants are provided. The bioimplants comprise biological tissues having conjugated thereto adjunct molecules. The biological tissues are sterilized with a chemical sterilizing agent, such as a water soluble carbodiimide. The processes of making the bioimplants include a process in which an adjunct molecule is conjugated to a biological tissue during the sterilization process. | 08-06-2009 |
20100266559 | STABILIZED, STERILIZED COLLAGEN SCAFFOLDS WITH ACTIVE ADJUNCTS ATTACHED - Bioimplants and methods of making the bioimplants are provided. The bioimplants comprise biological tissues having conjugated thereto adjunct molecules. The biological tissues are sterilized with a chemical sterilizing agent, such as a water soluble carbodiimide. The processes of making the bioimplants include a process in which an adjunct molecule is conjugated to a biological tissue during the sterilization process. | 10-21-2010 |
Thomas W. Sander, Winona Lake, IN US
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20100016966 | Tissue Repair Device And Apparatus And Method For Fabricating Same - A method for fabricating a device for repairing torn tissue or muscle such as the meniscus of the knee. The device includes a pair of anchoring members having a plurality of barb-like projections extending outwardly therefrom. The anchoring members are joined by a flexible linking member which connects the ends of the anchoring members opposite one another. Such a device can be fabricated by insert molding of the appropriate members together. | 01-21-2010 |
Tom Sander, Alachua, FL US
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20120004660 | Multi-component cortical bone assembled implant - An implant composed substantially of cortical bone is provided for use in cervical Smith-Robinson vertebral fusion procedures. The implant is derived from allograft or autograft cortical bone sources, is machined to form a symmetrically or asymmetrically shaped (e.g. a substantially “D”-shaped) implant having a canal running therethrough according to methods of this invention, and inserted into the space between adjacent cervical vertebrae to provide support and induce fusion of the adjacent vertebrae. Osteogenic, osteoinductive or osteoconductive materials may be packed into the canal of the implant to expedite vertebral fusion and to allow autologous bony ingrowth. | 01-05-2012 |
Tomas Sander, New York, NY US
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20090070361 | INTEGRITY VERIFICATION OF PSEUDONYMIZED DOCUMENTS - One or more methods of generating a pseudonymizable document are described. A method comprises receiving a set of subdocuments and generating a first set of random values wherein each subdocument in the document corresponds to a first set random value. A second set of values is generated based on a subdocument and a corresponding value of the first set random value. A set of pseudonyms is generated wherein each subdocument in the document corresponds to at least one pseudonym of the pseudonym set. A third set of values is generated based on the second set of values and the pseudonym set and a summary value is generated based on the third set of values. | 03-12-2009 |
20110029780 | Systems and Methods for Conducting Transactions and Communications Using a Trusted Third Party - Systems and methods are provided for managing the transfer of electronic files. In one embodiment, a sender transfers an encrypted version of a file (such as a digitally encoded audio track, movie, document, or the like) to someone who wishes to receive it. The receiver computes a hash of the encrypted file, and sends it to a trusted third party. The trusted third party compares the hash that was computed by the receiver with another hash computed by the sender. If the two hashes match, the third party sends the file decryption key to the receiver. In some embodiments, the receiver may also send the third party payment information so that the sender, the content owner, and/or the third party can be paid for their role in the transaction. In a preferred embodiment, the payment information is only sent to, and/or used by, the third party once the third party has confirmed to the satisfaction of the receiver that the encrypted file in the receiver's possession will decrypt correctly. In some embodiments, the sender computes a hash of the encrypted version of the file and sends it directly to the third party. In other embodiments, the sender encrypts this hash using a key associated with the third party and sends the encrypted hash to the receiver, who then forwards it to the third party. | 02-03-2011 |
20110106731 | QUESTIONNAIRE GENERATION - A questionnaire generation process presents a first subset from a set of questions of the questionnaire and receives first answers from a user. The first answers are used to determine whether the first answers are sufficient to give definite values to conditions of first rules, wherein the first rules have conditions for providing output. When the first answers are not sufficient, the conditions of the first rules can be used to identify a second subset of the questions, wherein the second subset of questions has second answers such that a combination of the first and second answers is sufficient to give definite values to the respective conditions of the first rules, and the second subset of questions can be presented to the user. | 05-05-2011 |
20110214169 | Secure Authentication Systems and Methods - Systems and methods are provided for authentication by combining a Reverse Turing Test (RTT) with password-based user authentication protocols to provide improved resistance to brute force attacks. In accordance with one embodiment of the invention, a method is provided for user authentication, the method including receiving a username/password pair associated with a user; requesting one or more responses to a first Reverse Turing Test (RTT); and granting access to the user if a valid response to the first RTT is received and the username/password pair is valid. | 09-01-2011 |
20120204246 | ESTABLISHING A SECURE CHANNEL WITH A HUMAN USER - A method of establishing a secure channel between a human user and a computer application is described. A secret unique identifier (“PIN”) is shared between a user and an application. When the user makes a request that involves utilizing the PIN for authentication purposes, the application renders a randomly selected identifier. The randomly selected identifier is in a format that is recognizable to a human but is not readily recognizable by an automated agent. The randomly selected identifier is then presented to the human user. The user identifies the relationship between the randomly selected identifier and the PIN. If the user's input reflects the fact that the user knows the PIN, then the user is authenticated. | 08-09-2012 |
20120266226 | SECURE AUTHENTICATION SYSTEMS AND METHODS - Systems and methods are provided for authentication by combining a Reverse Turing Test (RTT) with password-based user authentication protocols to provide improved resistance to brute force attacks. In accordance with one embodiment of the invention, a method is provided for user authentication, the method including receiving a username/password pair associated with a user; requesting one or more responses to a first Reverse Turing Test (RTT); and granting access to the user if a valid response to the first RTT is received and the username/password pair is valid. | 10-18-2012 |
20130013493 | SYSTEMS AND METHODS FOR CONDUCTING TRANSACTIONS AND COMMUNICATIONS USING A TRUSTED THIRD PARTY - Systems and methods are provided for performing transactions and managing communications using a trusted third party. In one embodiment, a sender transfers an encrypted version of a file (such as a digitally encoded audio track, movie, document, or the like) to someone who wishes to receive it. The receiver computes a first hash of at least a portion of the encrypted data content, and sends the first hash to a third party configured to compare at least a portion of the first hash to at least a portion of a second hash. The receiver receives a file decryption key from the third party, and decrypts at least the portion of the received encrypted data content with the decryption key. In some cases, multiple hashes of the encrypted data content may be computed, each using a different portion of the encrypted data content. | 01-10-2013 |
20130117075 | PROJECT COMPLIANCE ASSESSMENT - Compliance of a project is assessed by generating a graph including nodes representing attributes of the project, and populating a subset of nodes in the graph with attribute values of the project. A rule applicable to the subset of nodes is identified and applied to determine whether the attribute values comply with the rule. | 05-09-2013 |
20140058952 | SYSTEMS AND METHODS FOR CONDUCTING TRANSACTIONS AND COMMUNICATIONS USING A TRUSTED THIRD PARTY - Systems and methods are provided for performing transactions and managing communications using a trusted third party. In one embodiment, a sender transfers an encrypted version of a file (such as a digitally encoded audio track, movie, document, or the like) to someone who wishes to receive it. The receiver computes a first hash of at least a portion of the encrypted data content, and sends the first hash to a third party configured to compare at least a portion of the first hash to at least a portion of a second hash. The receiver receives a file decryption key from the third party, and decrypts at least the portion of the received encrypted data content with the decryption key. In some cases, multiple hashes of the encrypted data content may be computed, each using a different portion of the encrypted data content. | 02-27-2014 |
20140196135 | SECURE AUTHENTICATION SYSTEMS AND METHODS - Systems and methods are provided for authentication by combining a Reverse Turing Test (RTT) with password-based user authentication protocols to provide improved resistance to brute force attacks. In accordance with one embodiment of the invention, a method is provided for user authentication, the method including receiving a username/password pair associated with a user; requesting one or more responses to a first Reverse Turing Test (RTT); and granting access to the user if a valid response to the first RTT is received and the username/password pair is valid. | 07-10-2014 |
20140214938 | IDENTIFYING PARTICIPANTS FOR COLLABORATION IN A THREAT EXCHANGE COMMUNITY - Identifying participants for collaboration in a threat exchange community can include receiving security data from a plurality of participants at a threat exchange server within the threat exchange community; and in response to receiving from a first participant from the plurality of participants security data associated with a security occurrence, identifying at the threat exchange server the first participant and a second participant from the plurality of participants for collaboration based on characteristics of the first participant and the second participant. | 07-31-2014 |
20140215607 | THREAT EXCHANGE INFORMATION PROTECTION - Threat exchange information protection can include receiving security information from a number of participants of a threat exchange community, wherein a portion of the received security information is encoded with pseudonyms by each of the number of participants, analyzing the security information collectively from the number of participants, wherein the portion of the received security information remains encoded, and sending analysis results to each of the number of participants, wherein the analysis results include information relating to the portion. | 07-31-2014 |
20140215608 | SECURITY THREAT ANALYSIS - An example of security threat analysis can include generating a security threat hypothesis based on security data in a threat exchange server. A request for analysis based on the security data can be sent via communication links to at least one security monitored participant to analyze the security data. A response can be received from the at least one security monitored participant with information related to the completed security related task. | 07-31-2014 |
20140215616 | ATTACK NOTIFICATION - Systems, methods, and machine-readable and executable instructions are provided for attack notification. Attack notification can include receiving security-related data from a number of computing devices that are associated with a number of entities through a communication link and analyzing a first portion of the security-related data that is associated with a first entity from the number of entities to determine whether the first entity has experienced an attack. Attack notification can include analyzing a second portion of the security-related data that is associated with a second entity from the number of entities and the first portion of the security-related data that is associated with the first entity to determine whether the second entity is experiencing the attack. Attack notification can include notifying, through the communication link, the second entity that the second entity is experiencing the attack if it is determined that the second entity is experiencing the attack. | 07-31-2014 |
20150215329 | Pattern Consolidation To Identify Malicious Activity - A process includes analyzing events reported by computing devices on a network to recognize patterns of events that occurred on the network and sharing with a community, information concerning the patterns detected. The process may also use consolidated information on the patterns to select one or more of the patterns for analysis that identifies whether the selected patterns result from malicious activity. The consolidated information includes information on the patterns detected on the network and information concerning corresponding patterns of events that occurred elsewhere. | 07-30-2015 |
Tomas Sander, Princeton, NJ US
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20150371044 | TARGETED SECURITY ALERTS - Providing a targeted security alert can include collecting participant data from a plurality of participants within a threat exchange community, calculating, using a threat exchange server, a threat relevancy score of a participant among the plurality of participants within the threat exchange community using the collected participant data, and providing, from the threat exchange server to the participant, the targeted security alert based on the calculated threat relevancy score via a communication link within the threat exchange community. | 12-24-2015 |
20150373040 | SHARING INFORMATION - Sharing information can include identifying, utilizing a threat exchange server, a security occurrence associated with a participant within a threat exchange community. Sharing information can also include determining what participant-related information to share with the threat exchange server in response to the identified security occurrence, and receiving, at the threat exchange server, information associated with the determined participant-related information via communication links within the threat exchange community. | 12-24-2015 |
Tony L. Sander, Madison, AL US
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20110021761 | Segmented Polymers and Their Conjugates - Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation to various moieties such as pharmacologically active substances. Also described are conjugates of such polymers and methods of their preparation. | 01-27-2011 |
20110046315 | Method for Preparing Conjugates Using Polymer Maleimides - Methods for preparing conjugates using polymeric reagents bearing a maleimide are provided. Also provided are compositions comprising the conjugates. | 02-24-2011 |
20120022220 | Method for Preparing Polymer Maleimides - Methods for preparing polymeric reagents bearing a maleimide are provided. Also provided are related compositions. | 01-26-2012 |
20120027714 | Segmented Polymers and Their Conjugates - Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation to various moieties such as pharmacologically active substances. Also described are conjugates of such polymers and methods of their preparation. | 02-02-2012 |
20120271000 | COMPOSITIONS COMPRISING CONJUGATES AND MALEAMIC ACID-TERMINATED, WATER-SOLUBLE POLYMERS - Methods for preparing conjugates using polymeric reagents bearing a maleimide are provided. Also provided are compositions comprising the conjugates. | 10-25-2012 |