Cushing, US
Anna Mcginty Cushing, New York, NY US
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20150140553 | HIGH EFFICIENCY MULTIPLEXED NUCLEIC ACID CAPTURE IN A STRUCTURED MICROENVIRONMENT - Provided herein is a method for sample analysis. In some embodiments, the method may involve: a) enzymatically attaching a reactive group to nucleic acid molecules in a sample; b) covalently reacting the reactive group with surface exposed reactive sites on a porous support, thereby covalently tethering the nucleic acid molecules to the porous support; c) performing a primer extension reaction using the tethered nucleic acid molecules as a template to produce primer extension products; and d) eluting the primer extension products from the porous support, while leaving the tethered nucleic acid molecules tethered to the porous support. | 05-21-2015 |
Christopher R. Cushing, Palatine, IL US
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20100214995 | COMMUNICATING SYSTEM INFORMATION IN A WIRELESS COMMUNICATION NETWORK - An apparatus and method for communicating system information in a wireless communication network. A first step | 08-26-2010 |
Daniel Cushing, Phoenixville, PA US
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20090216554 | System and Method for Outcome-Based Management of Medical Science Liasons - A system and method for managing customer interaction activities of medical liaison personnel of a sponsor organization with health professional customers to achieve one or more desired business outcomes is disclosed. The system uses a customer relation database to record data regarding customer interaction activity of the medical liaison personnel and data regarding the business outcomes achieved or not achieved during the predetermined time period. The system correlates the customer interaction activity data and the business outcome data so that it can be used to conduct capacity and tactical assessments for future medical liaison activities. A method for targeting medical thought leaders or other health professionals who are most likely to achieve the business outcomes is also disclosed. In one embodiment, the system also provides a method for surveying the health professional customers to determine their level of satisfaction with medical liaison personnel and sponsor organization. | 08-27-2009 |
20120142768 | FORMULATIONS INCLUDING AMIODARONE AND SALTS THEREOF AND METHODS OF THEIR MANUFACTURE AND USE - The invention encompasses ready to administer liquid formulations including amiodarone and a substituted cyclodextrin. The invention also encompasses methods of making the liquid formulations to provide acceptable concentrations of amiodarone suitable for parenteral administration. The liquid formulations of the invention are formulations included, for example, in a ready to use intravenous bag, bottle or syringe. | 06-07-2012 |
Daniel J. Cushing, Phoenixville, PA US
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20100291056 | Pharmaceutical Compositions Comprising Prasugrel and Cyclodextrin Derivatives and Methods of Making and Using the Same - The present invention is directed to pharmaceutical compositions comprising prasugrel and a cyclodextrin derivative, and methods of making and using the same. | 11-18-2010 |
20100292268 | Formulations Containing Clopidogrel and Sulfoalkyl Ether Cyclodextrin and Methods of Use - The present invention provides compositions containing clopidogrel, present as a free base or a pharmaceutically acceptable salt thereof, and sulfoalkyl ether cyclodextrin (SAE-CD). The compositions can be liquid, suspension or solid compositions. They can be adapted for oral, peroral or parenteral administration. The SAE-CD serves to aid in dissolution and stabilization of the clopidogrel in aqueous media. The stability of clopidogrel against hydrolytic degradation, thermal degradation, and photolytic degradation are improved. SAE-CD provides improved results over other cyclodextrin derivatives. The SAE-CD-containing composition of clopidogrel can be provided in liquid form, solid form or as a reconstitutable powder. Both ready-to-use and concentrated liquid compositions can be prepared. The liquid composition is optionally available as a clear solution. The compositions herein can be administered perorally or parenterally and provide substantial pharmacokinetic, pharmacodynamic and/or therapeutic advantages over a tablet composition administered perorally and excluding SAE-CD. | 11-18-2010 |
20130012534 | Pharmaceutical Compositions Comprising Prasugrel and Cyclodextrin Derivatives and Methods of Making and Using the Same - The present invention is directed to pharmaceutical compositions comprising prasugrel and a cyclodextrin derivative, and methods of making and using the same. | 01-10-2013 |
20130129700 | FORMULATIONS CONTAINING CLOPIDOGREL AND SULFOALKYL ETHER CYCLODEXTRIN AND METHODS OF USE - The present invention provides compositions containing clopidogrel, present as a free base or a pharmaceutically acceptable salt thereof, and sulfoalkyl ether cyclodextrin (SAE-CD). The compositions can be liquid, suspension or solid compositions. They can be adapted for oral, peroral or parenteral administration. The SAE-CD serves to aid in dissolution and stabilization of the clopidogrel in aqueous media. The stability of clopidogrel against hydrolytic degradation, thermal degradation, and photolytic degradation are improved. SAE-CD provides improved results over other cyclodextrin derivatives. The SAE-CD-containing composition of clopidogrel can be provided in liquid form, solid form or as a reconstitutable powder. Both ready-to-use and concentrated liquid compositions can be prepared. The liquid composition is optionally available as a clear solution. The compositions herein can be administered perorally or parenterally and provide substantial pharmacokinetic, pharmacodynamic and/or therapeutic advantages over a tablet composition administered perorally and excluding SAE-CD. | 05-23-2013 |
20150025243 | FORMULATIONS CONTAINING CLOPIDOGREL AND SULFOALKYL ETHER CYCLODEXTRIN AND METHODS OF USE - The present invention provides compositions containing clopidogrel, present as a free base or a pharmaceutically acceptable salt thereof, and sulfoalkyl ether cyclodextrin (SAE-CD). The compositions can be liquid, suspension or solid compositions. They can be adapted for oral, peroral or parenteral administration. The SAE-CD serves to aid in dissolution and stabilization of the clopidogrel in aqueous media. The stability of clopidogrel against hydrolytic degradation, thermal degradation, and photolytic degradation are improved. SAE-CD provides improved results over other cyclodextrin derivatives. The SAE-CD-containing composition of clopidogrel can be provided in liquid form, solid form or as a reconstitutable powder. Both ready-to-use and concentrated liquid compositions can be prepared. The liquid composition is optionally available as a clear solution. The compositions herein can be administered perorally or parenterally and provide substantial pharmacokinetic, pharmacodynamic and/or therapeutic advantages over a tablet composition administered perorally and excluding SAE-CD. | 01-22-2015 |
20160058786 | FORMULATIONS CONTAINING CLOPIDOGREL AND SULFOALKYL ETHER CYCLODEXTRIN AND METHODS OF USE - The present invention provides compositions containing clopidogrel, present as a free base or a pharmaceutically acceptable salt thereof, and sulfoalkyl ether cyclodextrin (SAE-CD). The compositions can be liquid, suspension or solid compositions. They can be adapted for oral, peroral or parenteral administration. The SAE-CD serves to aid in dissolution and stabilization of the clopidogrel in aqueous media. The stability of clopidogrel against hydrolytic degradation, thermal degradation, and photolytic degradation are improved. SAE-CD provides improved results over other cyclodextrin derivatives. The SAE-CD-containing composition of clopidogrel can be provided in liquid form, solid form or as a reconstitutable powder. Both ready-to-use and concentrated liquid compositions can be prepared. The liquid composition is optionally available as a clear solution. The compositions herein can be administered perorally or parenterally and provide substantial pharmacokinetic, pharmacodynamic and/or therapeutic advantages over a tablet composition administered perorally and excluding SAE-CD. | 03-03-2016 |
Daniel Joseph Cushing, Phoenixville, PA US
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20130101514 | COMPOSITIONS AND METHODS FOR TREATING NEPHROPATHY - Activated fatty acids, pharmaceutical composition compositions including activated fatty acids, methods for using activated fatty acids to treat nephropathy, and methods for preparing activated fatty acids are provided herein. | 04-25-2013 |
20160081961 | COMPOSITIONS AND METHODS FOR TREATING NEPHROPATHY - Activated fatty acids, pharmaceutical composition compositions including activated fatty acids, methods for using activated fatty acids to treat nephropathy, and methods for preparing activated fatty acids are provided herein. | 03-24-2016 |
Daniel W. Cushing, Covington, WA US
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20100059900 | Translucent, Flame Resistant Composite Materials - A translucent composite material that can be used in various airplane interior applications that allows sufficient light transmissivity while preferably meeting Federal Aviation Administration (FAA) flammability requirements for overhead materials in the cabin of a commercial aircraft. The material also meets FAA standards regarding vertical burn, smoke emissions tests, and toxic fume emissions tests. The composite material is formed by laminating long glass fibers and (PPSU) into a composite sheet under controlled heat and pressure. The composite sheet is then cut, bent or thermoformed to form the desired part. The parts formed are available for a wide variety of uses within the passenger cabin of a commercial aircraft. The long glass fibers may be unidirectional or weaved into a glass cloth like material. While preferably formed for airplane interior applications, these components may also be used in other aerospace or non-aerospace applications. | 03-11-2010 |
20120156440 | Translucent, Flame Resistant Composite Materials - A translucent composite material comprises a substrate and a plurality of glass fibers embedded within the substrate. The substrate may comprise a substantially continuous nonwoven, non-fabric, translucent thermoplastic polyphenylsulfone substrate. The plurality of glass fibers may substantially span across a length of the substrate and may have an orientation, a fiber thickness, and a fiber area density selected to provide the translucent composite material with a strength, a flame-resistance, and a light transmissivity. | 06-21-2012 |
David Cushing, Lexington, MA US
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20090083175 | AUTOMATED BATCH AUCTIONS IN CONJUNCTION WITH CONTINUOUS FINANCIAL MARKETS - A method and system for performing a batch auction whereby a series of orders, according to a variety of predetermined order types, are generated by qualified market participants and communicated to an auction system. The auction system takes into account each order and its impact upon relative supply and demand to determine by a preset algorithm a price and share transaction quantity. Trades are executed at the price, and a portion of the transaction quantity is allocated to each investor on a fair basis dependent upon their initial orders. In embodiments of the present invention, the auction system uses a computer system or network designed to automatically perform one or more steps of the above method. Such a system is preferably connected to one or more ECNs such that non-executed shares can be automatically sent to outside sources for execution. In alternative embodiments, the invention includes the use of a one or more intermediaries or market makers to cover certain unexecuted trades at the determined price. The present invention is preferably used to conduct batch auctions at the opening and closing of securities trading markets. | 03-26-2009 |
20100076887 | AUTOMATED BATCH AUCTIONS IN CONJUNCTION WITH CONTINUOUS FINANCIAL MARKETS - A method and system for performing a batch auction whereby a series of orders, according to a variety of predetermined order types, are generated by qualified market participants and communicated to an auction system. The auction system takes into account each order and its impact upon relative supply and demand to determine by a preset algorithm a price and share transaction quantity. Trades are executed at the price, and a portion of the transaction quantity is allocated to each investor on a fair basis dependent upon their initial orders. In embodiments of the present invention, the auction system uses a computer system or network designed to automatically perform one or more steps of the above method. Such a system is preferably connected to one or more ECNs such that non-executed shares can be automatically sent to outside sources for execution. In alternative embodiments, the invention includes the use of a one or more intermediaries or market makers to cover certain unexecuted trades at the determined price. The present invention is preferably used to conduct batch auctions at the opening and closing of securities trading markets. | 03-25-2010 |
20130124381 | SYSTEM, METHOD, AND COMPUTER PROGRAM PRODUCT FOR EXECUTING A BUY OR SELL ORDER - An auto-trading strategy for executing an order to buy or sell a specified quantity of a certain item. The strategy utilizes urgency scores rather than time bins. In one embodiment, an urgency score is determined at a certain point in time. The urgency score is a function of a trading target associated with the point in time and the actual number of items that have been traded as of the certain point in time. | 05-16-2013 |
20140081822 | AUTOMATED BATCH AUCTIONS IN CONJUNCTION WITH CONTINUOUS FINANCIAL MARKETS - A method and system for performing a batch auction whereby a series of orders, according to a variety of predetermined order types, are generated by qualified market participants and communicated to an auction system. The auction system takes into account each order and its impact upon relative supply and demand to determine by a preset algorithm a price and share transaction quantity. Trades are executed at the price, and a portion of the transaction quantity is allocated to each investor on a fair basis dependent upon their initial orders. In embodiments of the present invention, the auction system uses a computer system or network designed to automatically perform one or more steps of the above method. Such a system is preferably connected to one or more ECNs such that non-executed shares can be automatically sent to outside sources for execution. In alternative embodiments, the invention includes the use of a one or more intermediaries or market makers to cover certain unexecuted trades at the determined price. The present invention is preferably used to conduct batch auctions at the opening and closing of securities trading markets. | 03-20-2014 |
David Cushing, Rochester Hills, MI US
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20140030688 | SYSTEMS, METHODS AND PROGRAM PRODUCTS FOR COLLECTING AND DISPLAYING QUERY RESPONSES OVER A DATA NETWORK - One method for communicating recommendations over a data network, comprising the steps of an initiating participant asking a question of a primary responder over the network; the primary responder providing a first answer to the question over the network and recommending at least one secondary responder to provide an answer to the question; each of the at least one secondary responder providing a second answer to the question over the network and further recommending at least one tertiary responder to provide an answer to the question; the at least one tertiary responder providing a third answer to the question over the network; and, a computer receiving each of the first, second and third answers and displaying them in a hierarchical manner. | 01-30-2014 |
David C. Cushing, Lexington, MA US
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20100121754 | SYSTEM AND METHOD FOR EXECUTING STRATEGY SECURITY TRADING - A computer implemented method and system for executing block trades for a security includes steps or devices for receiving a block trade request, at a computer system. The block request includes data representing a quantity of shares of the security to be traded over a period of time. The computer system divides the period of time into a plurality of time bins. A computer system, for the received block trade request, computes, for each time bin, a number of shares to be traded as a trading target based on at least historical trading volumes using predictive analysis. For a first time bin, a computer system generates executable trade orders for a number of shares to be traded that is substantially equal to the trading target for the first time bin. A computer system executes at least a portion of the executable trade orders in a trade forum within each time bin in the future. | 05-13-2010 |
20110276459 | SYSTEM AND METHOD FOR EXECUTING STRATEGY SECURITY TRADING - A computer implemented method and system for executing block trades for a security includes steps or devices for receiving a block trade request, at a computer system. The block request includes data representing a quantity of shares of the security to be traded over a period of time. The computer system divides the period of time into a plurality of time bins. A computer system, for the received block trade request, computes, for each time bin, a number of shares to be traded as a trading target based on at least historical trading volumes using predictive analysis. For a first time bin, a computer system generates executable trade orders for a number of shares to be traded that is substantially equal to the trading target for the first time bin. A computer system executes at least a portion of the executable trade orders in a trade forum within each time bin in the future. | 11-10-2011 |
20140358761 | SYSTEM AND METHOD FOR EXECUTING STRATEGY SECURITY TRADING - A computer implemented method and system for executing block trades for a security includes steps or devices for receiving a block trade request, at a computer system. The block request includes data representing a quantity of shares of the security to be traded over a period of time. The computer system divides the period of time into a plurality of time bins. A computer system, for the received block trade request, computes, for each time bin, a number of shares to be traded as a trading target based on at least historical trading volumes using predictive analysis. For a first time bin, a computer system generates executable trade orders for a number of shares to be traded that is substantially equal to the trading target for the first time bin. A computer system executes at least a portion of the executable trade orders in a trade forum within each time bin in the future. | 12-04-2014 |
David Charles Cushing, Lexington, MA US
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20100299283 | SYSTEMS AND METHODS FOR DELIVERING PARAMETERS TO AUTOMATED SECURITY ORDER EXECUTION SYSTEMS - In one aspect, the present invention permits users of trading algorithms to jointly achieve the objectives described above, namely: (a) permit access to trading algorithms of (arbitrary) complexity without requiring proprietary protocol extensions; (b) allow users to easily identify and store one or more sets of dynamic vs. static parameters (and related details, including user interface layout); and (c) allow any given pre-defined set of parameters to be easily invoked and used to submit orders. In another aspect, the invention comprises a computer system comprising: (a) an authoring tool operable to enable a user to design custom trading strategies and create interface definitions; and (b) a pre-processor operable to receive a custom strategy order message delivered via a standard protocol, load an definition for a corresponding custom strategy, enrich the order message based on the definition, and pass the enriched message to a trading strategy destination. | 11-25-2010 |
20100325032 | SYSTEMS AND METHODS FOR DELIVERING PARAMETERS TO AUTOMATED SECURITY ORDER EXECUTION SYSTEMS - In one aspect, the present invention permits users of trading algorithms to jointly achieve the objectives described above, namely: (a) permit access to trading algorithms of (arbitrary) complexity without requiring proprietary protocol extensions; (b) allow users to easily identify and store one or more sets of dynamic vs. static parameters (and related details, including user interface layout); and (c) allow any given pre-defined set of parameters to be easily invoked and used to submit orders. In another aspect, the invention comprises a computer system comprising: (a) an authoring tool operable to enable a user to design custom trading strategies and create interface definitions; and (b) a pre-processor operable to receive a custom strategy order message delivered via a standard protocol, load an definition for a corresponding custom strategy, enrich the order message based on the definition, and pass the enriched message to a trading strategy destination. | 12-23-2010 |
20110047095 | Systems and Methods for Order Analysis, Enrichment and Execution - A preferred embodiment of the invention provides an interface providing a model-driven projection of various order execution statistics based on the exact strategy (channel, algorithm, and parameters) that is selected by a user. In at least one embodiment, the interface is linked to at least order execution system and comprises an order execution display. In one embodiment, the invention comprises a computer system operable to display a graphical user interface comprising (a) a pre-trade analysis component for displaying market intelligence information regarding one or more specified securities; and (b) a strategy selection component for displaying order execution strategies for selection by a user and that comprises (i) an order execution component for routing a selected order execution strategy to an order execution system; (ii) an interface for enabling a user to specify trading strategies and strategy requirements; and (iii) a display for displaying projected order completion information. | 02-24-2011 |
Eric Cushing, Riverside, CA US
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20150201764 | SECURE HOLD HOOK - A secure hold hook is shown and described. The secure hold hook may include a body having first and second portions and a pair of opposed surfaces, a hook monolithically formed with the body, the hook extending from a first of the pair of opposed surfaces and a first adhesive adhered with a second of the pair of opposed surfaces. The secure hold hook may also include a second adhesive extending from the first adhesive, and a hinge positioned between the first and second portions, the hinge configured to permit the first and second portions to pivot with respect to one another. | 07-23-2015 |
20150204376 | DEVICE FOR HANGING ITEMS ON A VERTICAL SURFACE AND METHOD FOR MAKING AND USING SAME - The present invention relates to a device designed to permit various items to be hung on a vertical surface (e.g., the hanging of a picture or other piece of framed art or memorabilia on a wall), to a method of making such a device and to a method of using same. In one embodiment, the present invention relates to a two piece device where a first body, or rail, piece and a second body, or rail, piece each engage one of either the object, regardless of whether or not such object is framed or unframed, to be hung or the wall on which the object to be hung is to be placed, wherein the first piece and the second piece are formed so as to engage one another thereby resulting in the hanging of the object on a desired place on a wall. In another embodiment, the present invention relates to a two piece wall hanging device that permits the level hanging of an object on a wall regardless of whether or not each of the two pieces of the device are attached in a level manner to each of the wall and the object to be hung. | 07-23-2015 |
20160107785 | STACKABLE BOXES - A stackable container as shown and described herein. The stackable container may include an outer container having a bottom panel, a pair of opposite side walls and an end wall that extend from the bottom panel respectively. Said bottom panel may have at least one slot. A plurality of locking tabs may extend downward through said slots and a top panel may extend from the end wall wherein the top panel may be adapted to be pivoted between an open position and a closed position a front panel may extend from the bottom panel may be adapted pivot between an open position and a closed position. An inner container may be configured to be slidingly received within the outer container when the front panel is in the open position. | 04-21-2016 |
Eric J. Cushing, Los Angeles, CA US
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20120315422 | Label Pad and Related Methods - A label pad including one or more label assemblies and a related method. The label pad has a first label assembly having a first liner portions and a first face portion. The first face portion is positioned over the first liner portion and releasably coupled thereto. The label pad also includes a support, and the first label assembly is positioned over the support. The label pad also includes a first retaining member that is configured to couple at least a portion of the first liner portion of the first label assembly sufficiently to restrain the portion of the first liner portion from separating from the support when the first face portion is peeled away from the support. | 12-13-2012 |
20140259818 | TENT CARD AND METHODS OF MAKING AND USING THE SAME - An apparatus that is configured to stand on a supporting surface and methods of making and using the same. According to one embodiment, the apparatus includes a print-receptive surface and a biasing mechanism. The biasing mechanism is configured to bias the print-receptive surface into a standing configuration relative to the supporting surface. | 09-18-2014 |
Eric R. Cushing, Riverside, CA US
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20150104238 | SINGLE BOOSTER BINDER MECHANISM - A binder mechanism is shown and described herein. The binder mechanism may include a base, first and second ring bases pivotally coupled to the base, first and second ring portions fixed with the ring bases, at least one pin attached with the first and second ring bases, a slide operatively engaged with the base and operatively engaged with the at least one pin, the slide selectively and axially positionable relative to the base, and an actuator operatively engaged with the slide, where the actuator is configured to selectively and axially position the slide whereby the slide positions the at least one pin to pivot the first and second ring bases away from one another to disengage the first and second ring portions. | 04-16-2015 |
Hugh A. Cushing, New York, NY US
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20130024834 | MANAGING AN APPLICATION DEVELOPMENT ENVIRONMENT - Aspects of the invention provide for managing an application development environment. In one embodiment, aspects of the invention include a computer-implemented method of managing an application development environment, the method including: receiving a request for an application build, wherein the application build has at least one dependency on at least one asset; and processing the request for the application build in response to receiving the request, the processing including: submitting at least one query to an asset management system for at least one asset containing a dependency needed for the build, wherein the asset management system separately manages the plurality of assets apart from the application development environment; and receiving at least one asset from the asset management system in response to submitting at least one query. | 01-24-2013 |
Jesse Cushing, Bothell, WA US
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20150048209 | Structures with Internal Microstructures to Provide Multifunctional Capabilities - A structural spacecraft component comprising internal microstructure; wherein said microstructure comprises a plurality of parallel layers and a plurality of spacers that connect adjacent parallel layers; wherein said structural spacecraft component is a product of an additive manufacturing process. | 02-19-2015 |
Kathryn Cushing, San Francisco, CA US
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20140068440 | POP OUT MUSIC CONTROL PANE IN BROWSER - Methods, systems and computer programs are presented for generating media tabs for playing media files of various websites or applications. One method includes detecting a selected website through a browser and scanning the selected website to identify media files. For identified media files in the selected website, the method creates a media tab for association with the browser. The method generates a unified set of media controls for the media tab, where the unified set of media controls is mapped to native controls of the selected website having the media files. The method provides tab rendering data for the media tab. The tab rendering data is configured for associating the media tab with the browser. The tab rendering data, when associated with the browser, enables input at the media tab to be communicated to selected ones of the native controls, without accessing the native controls at the selected website. | 03-06-2014 |
20140122234 | ENTITY BASED ADVERTISEMENT TARGETING - Various aspects of the subject technology relate to systems, methods, and machine-readable media for targeting an advertisement based on an entity. A system is configured to receive a search query submitted by a user, identify an entity in a concept entity graph based on the search query, determine whether an advertisement corresponds to the identified entity, and provide, if the advertisement corresponds to the entity, the advertisement for display to the user. | 05-01-2014 |
20150117513 | BANDWIDTH REDUCTION SYSTEM AND METHOD - A method and computing system for receiving a multi-frame video from a first user for transmission to a second user. A plurality of video frames included within the multi-frame video is selected. A reduced-bandwidth sample of the multi-frame video is generated from the plurality of video frames. The reduced-bandwidth sample is provided to the second user. | 04-30-2015 |
20150195454 | IMAGERY CAPTURE - A method and computing system for determining a time differential between an image capture initiation indicator and an image capture completion indicator on a client electronic device. In response to a short time differential, a photograph is captured using the client electronic device. In response to a long time differential, a video is captured using the client electronic device. | 07-09-2015 |
20150219746 | DETERMINING A GEOGRAPHIC LOCATION OF A COMPUTING DEVICE - The disclosed subject matter relates to computer-implemented methods for determining a geographic location of a computing device. In one aspect, a method includes receiving a first set of authentication credentials, corresponding to a user, from a first computing device. The method further includes receiving a second set of authentication credentials, corresponding to the same user, from a second computing device. The method includes correlating the first set of authentication credentials and the second set of authentication credentials, to determine that the same user is associated with each of the first computing device and the second computing device. The method further includes receiving location information from the second computing device. The method further includes associating with the first computing device, based on the correlation, the location information received from the second computing device. | 08-06-2015 |
20150253936 | DETECTION AND CONTROL OF MULTIMEDIA APPLICATIONS - A mechanism for automatically detecting and controlling active multimedia applications is provided. Software is installed on a computing device that detects a plurality of active multimedia sources, and then determines that one or more of the plurality of active multimedia sources accept remote control of one or more multimedia features. A software multimedia user interface, including graphically displayed interactive volume controls for the detected multimedia sources, is displayed and configured to enable a user to remotely control the respective audio levels of each detected multimedia program by graphic manipulation of respective interactive volume controls. | 09-10-2015 |
Kathryn Cushing, Mountain View, CA US
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20130246522 | METHODS AND SYSTEMS FOR ORDERING AND VOTING ON SHARED MEDIA PLAYLISTS - Methods and systems for managing ordering of media items for play is provided. The method includes establishing a session between two or more connected devices, and receiving a request from one of the connected device to create a shared media playlist. The shared media playlist accepting addition of a plurality of media items from at least one of the connected devices. Then, collecting vote input from one or more of the connected devices. The vote input is applied to selected ones of the plurality of media items in the shared media playlist. The method processes the collected vote input to set a score for at least one of the plurality of media items. The method orders the plurality of media items in the shared media playlist, such that playing of the plurality of media items during the session follow the ordering. | 09-19-2013 |
Kathryn Chapman Cushing, San Francisco, CA US
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20160088091 | Identifying Existing Synchronous Communication Sessions Associated with a User - Existing synchronous communication sessions associated with a user are identified. A request to display information about the user is received. A plurality of existing synchronous communication sessions is identified. Each existing synchronous communication session includes at least one participant and is associated with a user. An affinity score for each of the plurality of synchronous communication sessions is determined based on an affinity between the user and at least one of the participants of the synchronous communication session. The plurality of existing synchronous communication sessions associated with the user is ranked based on the affinity score. An indication of a subset of the plurality of existing synchronous communication sessions is sent for display on the one more computing devices. In some embodiments, an indication of one of the existing synchronous communication sessions is sent for display on the one more computing devices. | 03-24-2016 |
Kenneth Cushing, Great Falls, VA US
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20140156442 | SYSTEMS AND METHODS FOR SERVICE TRANSACTIONS AND CHARITABLE DONATIONS - Methods, systems, and computer program products are disclosed that provide an online marketplace for services from vendors. The method includes providing to service vendors a request for a service that a customer creates on the system. Further, the method includes receiving bids from the service vendors in response to the request for the service. The method further includes receiving a selection of one of the bids from the customer. The method further includes providing a payment to a selected vendor corresponding to the selected one of the bids. | 06-05-2014 |
Kevin Cushing, Albuquerque, NM US
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20120065329 | SYNTHESIS OF STABLE ELASTOMERIC NEGATIVE ACOUSTIC CONTRAST PARTICLES - We describe methods for synthesis and formulations of stable elastomeric negative acoustic contrast particles with controllable compressibility and density. These elastomeric negative acoustic contrast particles have a density/compressibility ratio that is less than that of water and therefore exhibit negative acoustic contrast under acoustic radiation exposure. This negative acoustic contrast allows our elastomeric negative acoustic contrast particles to be acoustically manipulated (e.g. separated) differently from other components (e.g. cells) within an aqueous solution. This disclosure also describes methods for biofunctionalization of the elastomeric negative acoustic contrast particles and as an example their use as platforms for bioassays. Potential applications of these elastomeric negative acoustic contrast particles include sensitive bioassays based on acoustic flow cytometry and other types of techniques that utilize acoustic fields, including ultrasound imaging and ultrasound triggered drug delivery. | 03-15-2012 |
Leanne Cushing, Brookline, MA US
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20140174838 | Front-Mounted Stand-On Lawn Care Vehicle - A riding lawn care vehicle may include a frame, an engine, a steering assembly, a support platform and a front mount assembly. The frame may be attachable to a pair of front wheels and a rear wheel assembly of the riding lawn care vehicle. At least a portion of the engine may be mounted to the frame substantially between the front wheels. The steering assembly may include steering levers operably coupled to respective ones of the front wheels of the riding lawn care vehicle via respective hydrostatic drive pumps driven by the engine. The steering assembly may enable steering of the riding lawn care vehicle based on drive speed control of the front wheels responsive to positioning of steering levers of the steering assembly. | 06-26-2014 |
Patrick R. Cushing, Shrewsbury, MA US
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20140011983 | SMALL MOLECULE CONJUGATES WITH DIMETAL SPECIES FOR PROTEIN INHIBITION - Methods for targeting a protein by providing an inhibitor covalently linked to a rhodium(II) complex, introducing the inhibitor to the target protein and allowing the inhibitor and protein to interact. The rhodium(II) complex covalently linked to the inhibitor binds the target protein both inorganically and organically and forms stabilizing secondary contacts between the rhodium(II) complex and the protein. | 01-09-2014 |
Patrick R. Cushing, Woburn, MA US
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20130060005 | COMPOSITIONS AND METHODS FOR INHIBITING THE INTERACTION BETWEEN CFTR AND CAL - The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention provides peptides and peptidomimetics that selectively inhibit the interaction between CAL and mutant CFTR proteins, thereby stabilizing the CFTR and facilitating transport of the same to the cell surface. | 03-07-2013 |
20140100155 | COMBINATION THERAPY AND KIT FOR THE PREVENTION AND TREATMENT OF CYSTIC FIBROSIS - A combination therapy and kit including an agent that inhibit the interaction between CAL and mutant CFTR proteins, in combination with a CFTR corrector, CFTR potentiator, mucolytic, anti-inflammatory agent or a combination thereof are provided as is a method for preventing or treating cystic fibrosis. | 04-10-2014 |
20150250848 | THERAPY AND KIT FOR THE PREVENTION AND TREATMENT OF CYSTIC FIBROSIS - A combination therapy and kit including an agent that inhibit the interaction between CAL and mutant CFTR proteins, in combination with a CFTR corrector, CFTR potentiator, mucolytic, anti-inflammatory agent or a combination thereof are provided as is a method for preventing or treating cystic fibrosis. | 09-10-2015 |
Patrick R. Cushing, East Thetford, VT US
Patent application number | Description | Published |
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20110201544 | Compositions and Methods for Inhibiting the Interaction between CFTR and CAL - The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention provides peptides and peptidomimetics that selectively inhibit the interaction between CAL and mutant CFTR proteins, thereby stabilizing the CFTR and facilitating transport of the same to the cell surface. | 08-18-2011 |
20120071396 | Compositions and Methods for Inhibiting the Interaction Between CFTR and CAL - The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention provides peptides and peptidomimetics that selectively inhibit the interaction between CAL and mutant CFTR proteins, thereby stabilizing the CFTR and facilitating transport of the same to the cell surface. | 03-22-2012 |
Sonia J. Cushing, Rochester, MN US
Patent application number | Description | Published |
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20090171735 | AUTOMATED KITTING FOR SHORT BUILD MANUFACTURING - A method for managing production of a product when components of the product are missing during a manufacturing process is provided. The method includes applying a first set of rules for determining whether a short work unit can be released for manufacturing and clearing the short work unit to build. The method further includes allocating for manufacturing components of the short work unit present in inventory and storing a record including a list of short components. The method further includes generating a first kit and storing a record including a location of the first kit. The method further includes initiating manufacturing of the first kit and determining that at least one of the short components of the short work unit are present in inventory. The method further includes generating a second kit for the short components of the short work unit that are present in inventory. | 07-02-2009 |
Timothy D. Cushing, Pacifica, CA US
Patent application number | Description | Published |
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20090023761 | Heterocyclic compounds and their uses - Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer. | 01-22-2009 |
20090030002 | Heterocyclic compounds and their uses - Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelodysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer. | 01-29-2009 |
20090137581 | Heterocyclic compounds and their uses - Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer. | 05-28-2009 |
20100179177 | HETEROCYCLIC COMPOUNDS AND THEIR USES - Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer. | 07-15-2010 |
20100331293 | HETEROCYCLIC COMPOUNDS AND THEIR USES - Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjogren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer. | 12-30-2010 |
20100331306 | HETEROCYCLIC COMPOUNDS AND THEIR USES - Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity. The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer. | 12-30-2010 |
20110086834 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS - Selected compounds are effective for prophylaxis and treatment of inflammation and inflammatory disorders, such as NIK-mediated disorders. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, inflammation and the like. | 04-14-2011 |
20110152277 | HETEROCYCLIC COMPOUNDS AND THEIR USES - Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer. | 06-23-2011 |
20110152296 | HETEROCYCLIC COMPOUNDS AND THEIR USES - Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer. | 06-23-2011 |
20110245257 | HETEROCYCLIC COMPOUNDS AND THEIR USES - Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer. | 10-06-2011 |
20110275653 | HETEROCYCLIC COMPOUNDS AND THEIR USES - Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer. | 11-10-2011 |
20110275811 | HETEROCYCLIC COMPOUNDS AND THEIR USES - Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity. The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelodysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer. | 11-10-2011 |
20110281897 | HETEROCYCLIC COMPOUNDS AND THEIR USES - Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity. The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer. | 11-17-2011 |
20120220585 | HETEROCYCLIC COMPOUNDS AND THEIR USES - Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer. | 08-30-2012 |
20120220586 | HETEROCYCLIC COMPOUNDS AND THEIR USES - Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer. | 08-30-2012 |
20150045361 | HETEROCYCLIC COMPOUNDS AND THEIR USES - Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer. | 02-12-2015 |
20150266824 | Pyrazole Amide Derivative - The present invention relates to a novel compound having a function of inhibiting RORγ activity. The present invention also relates to pharmaceutical composition comprising the compound, a use of the compound in treating or preventing autoimmune diseases, inflammatory diseases, metabolic diseases, or cancer diseases. | 09-24-2015 |
Timothy David Cushing, Pacifica, CA US
Patent application number | Description | Published |
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20120083502 | HETEROCYCLIC COMPOUNDS AND THEIR USES - Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer. | 04-05-2012 |
20120094972 | HETEROCYCLIC COMPOUNDS AND THEIR USES - Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer. | 04-19-2012 |
20130231352 | HETEROCYCLIC COMPOUNDS AND THEIR USES - Substituted bicyclic heteroaryls having the general formula (I) and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p1 108 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML), Myelodysplastic syndrome (MDS), myelo-proliferative diseases (MPD), Chronic Myeloid Leukemia (CML), T-cell Acute Lymphoblastic leukaemia (T-ALL), B-cell Acute Lymphoblastic leukaemia (B-ALL), Non Hodgkins Lymphoma (NHL), B-cell lymphoma and solid tumors, such as breast cancer. | 09-05-2013 |
20130267524 | HETEROCYCLIC COMPOUNDS AND THEIR USES - Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer. | 10-10-2013 |
20130267526 | HETEROCYCLIC COMPOUNDS AND THEIR USES - Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer. | 10-10-2013 |
20140206694 | HETEROCYCLIC COMPOUNDS AND THEIR USES - Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer. | 07-24-2014 |
Timothy J. Cushing, Howell, MI US
Patent application number | Description | Published |
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20100258090 | Apparatus For Reducing Fuel Waxing - A fuel filter for an internal combustion engine is provided comprising a fuel conduit configured to transport fuel from a fuel tank to an internal combustion engine. A fuel filter manifold has an inlet and an outlet for fluid communication with the fuel conduit. A fuel filter housing is associated with the fuel filter manifold and is configured to receive fuel from and dispense fuel to the fuel filter manifold. A filter element is disposed within the fuel filter housing between the inlet and the outlet and is configured to filter fuel passing through the fuel filter housing. An electromagnetic transducer is associated with the fuel filter and is configured to emit high frequency waves operable on the fuel to reduce, via ultrasonic cavitation, wax crystals suspended in the fuel. | 10-14-2010 |
20100258091 | Apparatus For Reducing Fuel Waxing - A fuel filter is configured to filter fuel for an internal combustion engine and is associated with an electromagnetic wave generator configured to emit high frequency electromagnetic waves operable on the fuel to heat and thereby melt wax crystals suspended in the fuel. | 10-14-2010 |
Tommy Cushing, Mckinney, TX US
Tommy Cushing, Prosper, TX US
Patent application number | Description | Published |
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20120035692 | IMPLANTABLE MEDICAL ANCHOR - There is disclosed various embodiments of an implantable anchor for permanently anchoring a medical lead or catheter. For instance, there is disclosed an implantable anchor including a body having a longitudinal lumen defined therein, wherein the longitudinal lumen is sized to accept a portion of the medical lead or catheter, a bending mechanism coupled to the body for bending the lead to a predetermined angle within the body, and a retaining mechanism for maintaining the predetermined angle of the bent lead within the body. | 02-09-2012 |
Tommy C. Cushing, Mckinney, TX US
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20090133699 | ORAL NASAL CANNULA - Disclosed is a respiratory cannula assembly to deliver and receive gases from a patient. The cannula assembly contains two oral prongs for delivering and receiving gases from the patient as well as at least one gas delivery nasal prong and at least one gas receiving nasal prong. The gas receiving nasal prong extends further into the patients nostril than the gas delivery nasal prong. The cannula assembly further contains a connector that aids in coupling to a medical device, the connector including independent oral and nasal moisture traps that remove moisture from exhaled patient gases. | 05-28-2009 |
Vincent J. Cushing, Chicago, IL US
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20120323637 | OPTIMIZATION OF ATTRIBUTES IN A PORTFOLIO OF COMMERCIAL AND INDUSTRIAL FACILITIES - Deployment of commercial and industrial (“C&I”) facilities in wholesale markets may be optimized by unbundling attributes from the facilities and combining those attributes for deployment. Buildings within portfolios may include complimentary attributes, features, and capabilities that can be coordinated for synergistic effect. The optimization may include mathematically unbundling attributes of each facility that may be mathematically and optimally aggregated into synthetic resources that are matched for selecting particular markets. These synthetic resources may be deployed optimally in the selected markets. | 12-20-2012 |
20130013121 | INTEGRATION OF COMMERCIAL BUILDING OPERATIONS WITH ELECTRIC SYSTEM OPERATIONS AND MARKETS - Buildings or facilities containing energy consuming or energy generating devices may be optimized for efficient energy usage and distribution. Energy consumption or generation by a building or components may be controlled by a system comprising a building model for predicting behavior of the building given predicted future conditions and possible control inputs. An optimization component running an optimization algorithm in conjunction with the building model may evaluate the predicted building behavior in accordance with at least one criterion and determine a desired set of control inputs. Commercial building thermal mass may be harnessed to continuously and optimally integrate large commercial building HVAC operations with electric grid operations and markets in large metropolitan areas. The service may be deployed using scalable, automated, web-based technology. | 01-10-2013 |
Yuet-Yuen Chan Cushing, Atlanta, GA US
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20100175850 | Relief Vent for a Hot Fill Fluid Container - Caps having porous elements that act as a vent to facilitate cooling of hot fluids stored in containers. Certain embodiments comprise a cap that may be affixed to a container filled with a hot fluid. The cap may include a porous element that allows air to enter the container during the cooling process, but also prevents the introduction of microbes and bacteria into the container. The cap may include a through hole, chamber, or recessed area to receive and secure the porous element. In certain embodiments the porous element may comprise a sintered composite material with thermoplastic particles and either metal particles and/or metal powder. In other embodiments, the porous element may comprise a layered structure. The layers may include a combination of the sintered composite material, a metallic layer, or various porous layers. | 07-15-2010 |