Basu, MA
Archan Basu, Lexington, MA US
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20150206245 | Dynamic Portfolio Simulator Tool Apparatuses, Methods and Systems - The Dynamic Portfolio Simulator Tool Apparatuses, Methods and Systems transforms market assumptions, constraints inputs via DPST components into asset allocation record, portfolio allocation and graphic presentation outputs. The DPST includes a dynamic portfolio simulator apparatus. The DPST includes a computing processor and memory, and the memory includes the following instructions. The DPST includes instructions to obtain a user indication of portfolio simulation request including user configured market assumption parameters and retrieve a user interface template comprising a portfolio parameter configuration widget. The DPST also includes instructions to calculate a parameter range for the portfolio parameter configuration widget based on the user configured market assumption parameters and customize the portfolio parameter configuration widget with the calculated parameter range. Then the DPST may provide the customized portfolio parameter configuration widget to a user device and obtain a user input of portfolio parameter via the customized portfolio parameter configuration widget. The DPST may also provide portfolio composite outputs based on the user input of portfolio parameter and provide the calculated portfolio composite outputs via the user interface. | 07-23-2015 |
Prabahan Basu, Lexington, MA US
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20100039233 | METHOD FOR SIMULTANEOUS DETECTION OF A PLURALITY OF RFID TAGS USING MULTIUSER DETECTION - A method and apparatus are disclosed that apply multiuser detection (MUD) analysis to an aggregated RF response from a plurality of simultaneously queried RFID tags, so as to distinguish the individual tag responses. The claimed method thereby significantly reduces RFID detection latency when multiple tags are simultaneously queried. Some embodiments transmit carrier waves at more than one frequency, such as a plurality of equally-spaced frequencies, so as to enhance the MUD analysis by incorporating a multi-frequency dimension. Other embodiments incorporate additional spatial dimensions by deploying multiple RF detection antennae at separated locations. The number of colliding tag responses must be estimated before MUD analysis can be applied. In some embodiments other signal parameters must be estimated, such as signal bias and an impulse function for each responding tag that characterizes alterations of the RF signal while in transit due to propagation distance, passage through intervening objects, and reflections. | 02-18-2010 |
20100208996 | DEVICES AND METHODS FOR RESTORING LOW-RESOLUTION TEXT IMAGES - A system that extracts text from an image includes a capture device that captures the image having a low resolution. An image segmentation subsystem partitions the image into image segments. An image restoration subsystem generates a resolution-expanded image from the image segments and negates degradation effects of the low-resolution image by transforming the image segments from a first domain to a second domain and deconvolving the transformed image segments in the second domain to determine parameters of the low-resolution image. A text recognition subsystem transforms the restored image data into computer readable text data based on the determined parameters. | 08-19-2010 |
Prithwish Basu, Cambridge, MA US
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20080232344 | Systems and methods for synchronizing communication networks - In many aspects, the invention relates to systems and methods for synchronizing a communication network, particularly a slotted communication network, having a plurality of nodes. In slotted communication networks, the nodes are configured to transmit or receive data during selected time slots. During a selected time slot, each node transmits a synchronization message that is received by a neighboring node. The neighboring node adjusts its time slot boundary to coincide with the time of receipt of the synchronization message, thereby synchronizing each node with a neighboring node. Such systems and methods are energy efficient, accurate, fast, fault tolerant and easy to implement. | 09-25-2008 |
20090129316 | Systems and methods for adaptive routing in mobile ad-hoc networks and disruption tolerant networks - The systems and methods described herein include adaptive routing processes for packet-based wireless communication networks. This routing approach works both in MANETs (when a contemporaneous end-to-end path is available) and in DTNs (when a contemporaneous end to end path is not available, but one of formed over space and time). In particular, the methods include adaptively selecting a routing process for transmitting a packet through a node in the network based on available information on the network topology and/or the contents of the packet. | 05-21-2009 |
Soumendra N. Basu, Westwood, MA US
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20090035561 | Protective oxide coatings for SOFC interconnections - A dense and well adhered spinel coating such as CuMn | 02-05-2009 |
Subhayu Basu, Chestnut Hill, MA US
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20120116108 | MICROORGANISMS AND METHODS FOR PRODUCING UNSATURATED FATTY ACIDS - Methods of producing an unsaturated free fatty acid comprising at least 18 carbon atoms are provided. In some embodiments, the methods comprise culturing an engineered microorganism in a culture medium, wherein the engineered microorganism comprises at least one recombinant enzyme selected from acyl-lipid desaturase delta-9 (EC:1.14.19.1), acyl-lipid desaturase delta-12 (EC:1.14.19.6), acyl-lipid desaturase delta-15 (EC:1.14.19.-), and thioesterase (EC:3.1.2.14). Engineered microorganisms comprising at least one of those recombinant enzymes are also provided. The methods and organisms can be used to produce at least one free fatty acid selected from oleic acid, linoleic acid and α-linolenic acid. | 05-10-2012 |
20150057352 | Microorganisms, Compositions, and Methods for Producing Fatty Acids - Methods of producing an unsaturated free fatty acid comprising at least 18 carbon atoms are provided. In some embodiments, the methods comprise culturing an engineered microorganism in a culture medium, wherein the engineered microorganism comprises at least one recombinant enzyme selected from acyl-lipid desaturase delta-9 (EC:1.14.19.1), acyl-lipid desaturase delta-12 (EC:1.14.19.6), acyl-lipid desaturase delta-15 (EC:1.14.19.-), and thioesterase (EC:3.1.2.14). Engineered microorganisms comprising at least one of those recombinant enzymes are also provided. The methods and organisms can be used to produce at least one free fatty acid selected from oleic acid, linoleic acid and α-linolenic acid. | 02-26-2015 |
20150093495 | Nucleic Acids, Cells, and Methods for Producing Secreted Proteins - A method for producing a secreted recombinant polypeptide sequence is provided. In some embodiments it comprises providing a recombinant microorganism comprising a recombinant nucleic acid comprising a first nucleic acid sequence encoding the recombinant polypeptide sequence operatively linked to a second nucleic acid sequence encoding a signal peptide; and culturing the recombinant microorganism in a culture medium under conditions sufficient for production and secretion of the recombinant protein by the recombinant microorganism. In some embodiments the coding sequence for the signal peptide is not native to the recombinant microorganism. In some embodiments the recombinant microorganism is photo synthetic. Also provided are recombinant photosynthetic microorganisms, isolated polypeptides comprising a signal peptide comprising an amino acid sequence disclosed herein, and isolated nucleic acids comprising a coding sequence for one of the signal peptides, among other things. | 04-02-2015 |
Subhayu Basu, Framingham, MA US
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20080287320 | Libraries and their design and assembly - Aspects of the invention relate to the design and synthesis of nucleic acid libraries containing non-random mutations or variants. Aspects of the invention provide methods for assembling libraries containing high densities of predetermined variant sequences. Certain embodiments relate to the design and synthesis of nucleic acid libraries that express a predetermined polypeptide from a library of nucleic acids having silent sequence variants. Certain embodiments relate to the design and synthesis of nucleic acid libraries that express predetermined RNA variants that encode the same polypeptide sequence. | 11-20-2008 |
Sudipta Basu, Cambridge, MA US
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20120189571 | NANOSCALE PLATINUM COMPOUNDS AND METHODS OF USE THEREOF - The invention is directed to biocompatible conjugated polymer nanoparticles including a copolymer backbone, a plurality of sidechains covalently linked to said backbone, and a plurality of platinum compounds dissociably linked to said backbone. The invention is also directed to dicarbonyl-lipid compounds wherein a platinum compound is dissociably linked to the dicarbonyl compound. The invention is also directed to methods of treating cancer or metastasis. The methods includes selecting a subject in need of treatment for cancer or metastasis and administering to the subject an effective amount of any of the nanoparticles, compounds, or compositions of the invention. | 07-26-2012 |
Sujit Basu, Newton, MA US
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20140377244 | STABLE FORMULATIONS FOR CNS DELIVERY OF ARYLSULFATASE A - The present invention provides, among oilier things, compositions and methods for CNS delivery of lysosomal enzymes (e.g., recombinant human arylsulfatase A (rhASA)) for effective treatment of lysosomal storage diseases (e.g. Metachromatic Leukodystrophy Disease). In some embodiments, the present invention includes a stable formulation for intrathecal administration comprising an ASA protein and a poloxamer, wherein less than 3% of the ASA protein exists in aggregated form. | 12-25-2014 |
Sujit K. Basu, Cambridge, MA US
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20110123574 | INHALABLE SUSTAINED THERAPEUTIC FORMULATIONS - The present invention is based, in part, on the unexpected discovery that particles for pulmonary delivery of a therapeutic, prophylactic or diagnostic agent that comprise a phospholipid and a sufficient amount of leucine can produce sustained effect of the agent. Specifically, particles for pulmonary delivery of a therapeutic, prophylactic or diagnostic agent that contain a phospholipid or combination of phospholipids, wherein the phospholipid or combination of phospholipids is present in the particles in an amount of about 1 to 46 weight percent; and leucine, wherein leucine is present in the particles in an amount of at least 46 weight percent, can contribute to sustained effect of the agent. Particles that comprise at least 46 weight percent leucine but that do not contain phospholipids do not exhibit these same sustained effect properties. | 05-26-2011 |
Sujit K. Basu, Newton, MA US
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20100216705 | HUMAN GROWTH HORMONE FORMULATIONS - Formulations containing complexed human growth hormone crystals are described. Also described are needleless injection systems for crystalline proteins. | 08-26-2010 |
20110059187 | PEPTIDE DICER SUBSTRATE AGENTS AND METHODS FOR THEIR SPECIFIC INHIBITION OF GENE EXPRESSION - This invention relates to compounds, compositions, and methods useful for reducing a target RNA and protein levels via use of Dicer substrate siRNA (DsiRNA)-peptide conjugates. | 03-10-2011 |
20110111056 | PEPTIDE DICER SUBSTRATE AGENTS AND METHODS FOR THEIR SPECIFIC INHIBITION OF GENE EXPRESSION - This invention relates to compounds, compositions, and methods useful for reducing a target RNA and protein levels via use of Dicer substrate siRNA (DsiRNA)-peptide conjugates. | 05-12-2011 |
20120088724 | Human Growth Hormone Formulations - Formulations containing complexed human growth hormone crystals are described. Also described are needleless injection systems for crystalline proteins. | 04-12-2012 |
Sujit Kumar Basu, Newton, MA US
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20140179765 | PHASE CHANGING FORMULATIONS OF NUCLEIC ACID PAYLOADS - The present invention is based, at least in part, upon discovery of a process for identifying phase changing peptides. Such phase changing peptides are capable of enhancing in vitro and in vivo delivery of oligonucleotides (e.g., dsRNAs) in lipidic, vesicular, micellar and/or naked oligonucleotide formulations. | 06-26-2014 |
20140371293 | Amine Cationic Lipids and Uses Thereof - The present invention relates to lipid compounds and uses thereof. In particular, the compounds include a class of cationic lipids having an amine moiety, such as an amino-amine or an amino-amide moiety. The lipid compounds are useful for in vivo or in vitro delivery of one or more agents (e.g., a polyanionic payload or an antisense payload, such as an RNAi agent). | 12-18-2014 |
Sujit Kumar Basu, Cambridge, MA US
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20090023629 | COMPOSITIONS COMPRISING POLYCATION-COMPLEXED PROTEIN CRYSTALS AND METHODS OF TREATMENT USING THEM - The present invention relates to compositions comprising polycation-complexed protein crystals and hyaluronic acid. Advantageously, the compositions of this invention are stable, long-acting and avoid local reactions at the injection site. Compositions according to this invention include sustained-release human growth hormone compositions. Such compositions are useful for treating a subject having a disorder associated with human growth hormone deficiency or that is ameliorated by human growth hormone therapy. | 01-22-2009 |