Pennypacker
Carl Pennypacker, El Cerrito, CA US
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20140194740 | Emboli detection in the brain using a transcranial doppler photoacoustic device capable of vasculature and perfusion measurement - A device, method, and system for detecting emboli in the brain is disclosed. A transcranial Doppler photoacoustic device transmits a first energy to a region of interest at an internal site of a subject to produce an image and blood flow velocities of a region of interest by outputting an optical excitation energy to said region of interest and heating said region, causing a transient thermoelastic expansion and produce a wideband ultrasonic emission. Detectors receive the wideband ultrasonic emission and then generate an image of said region of interest from said wideband ultrasonic emission. A Doppler ultrasound signal will also be deployed to image the region of interest. Doppler presents changes in velocity to map blood flow. Additionally, a dye can be given to visualize the brain vasculature and a perfusion measurement can be made in various regions of the brain along with the transcranial Doppler and the photoacoustic screening. Systems are taught using resultory medical data for better triage within an enhanced stroke ecosystem. | 07-10-2014 |
Carl R. Pennypacker, El Cerrito, CA US
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20120059254 | APPARATUS AND METHOD FOR PHASE-SPACE REDUCTION FOR IMAGING OF FLUORESCING, SCATTERING AND/OR ABSORBING STRUCTURES - A method and apparatus are disclosed for utilizing light, including ultraviolet, optical and/or infrared, for detecting a body in an object, such as biomaterial or tissue, animal and/or human tissue. The body or object may be made fluorescent by the use of dyes or agent. Light is used to illuminate the body and object and the scattered light, fluorescent and/or emitted light, reflected light and transmitted light are detected and used to reconstruct the body and/or object using an iterative analysis. Further, the method and apparatus may be extended to endoscopic applications to make subcutaneous images of internal tissue above, on, in or beyond endoscopic pathways such as esophagus, stomach, colon, bronchial tubes and/or other openings, cavities and spaces animate or inanimate, and in man-made or industrial materials as carbon/resin structures. | 03-08-2012 |
Carlton R. Pennypacker, El Cerrito, CA US
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20160030001 | Helmet Apparatus and System with Carotid Collar Means On-Boarded - Apparatus for helmeting with carotid collars works in conjunction with a transcranial Doppler, phased array photoacoustic device to transmit a first energy to a region of interest at an internal site of a subject to produce an image and blood flow velocities of a region of interest by outputting an optical excitation energy to said region of interest and heating said region, causing a transient thermoelastic expansion and produce a wideband ultrasonic emission. Systems integrate and register the signals for use in, for example, acute stroke care. | 02-04-2016 |
Jeffrey Pennypacker, Corning, NY US
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20140339453 | COMPRESSOR VALVE SEAT RECONDITIONING LIMIT INDICATOR - A compressor valve may include a guard and a seat affixed thereto. The seat may have an inlet surface and an outlet surface opposite the inlet surface. A reconditioning limit indicator may be defined by or adjacent the outlet surface. The reconditioning limit indicator may be indicative of a maximum amount of material of the seat removable from the outlet surface during reconditioning of the seat. The reconditioning limit indicator may be a groove defined by the outer cylindrical surface of the seat, a portion of the outer cylindrical surface of the seat adjacent the outlet surface and having an outer diameter smaller than the outer diameter of the seat, or a predetermined shape of a predetermined depth machined on the outlet surface of the seat. | 11-20-2014 |
Jeffrey George Pennypacker, Corning, NY US
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20080318448 | DIMM SOCKET POSITIVE LOCK EXTRACTOR - A card edge connector including a housing and a pair of extractors is disclosed for electrically connecting a first PCB such as a daughter card to a second PCB such as a motherboard. The extractors both secure and eject the daughter card from the connector. The extractors may be configured to reduce micro-motion of the daughter card by applying a vertical downward force thereto. | 12-25-2008 |
20090023332 | Electrical connector assembly with shorting contacts - An electrical connector assembly is provided. The electrical connector assembly includes a housing including a body fabricated at least partially from a dielectric material. The housing body has an opening therein. An electrical contact is held by the housing. The electrical contact includes an intermediate portion and a spring portion each held at least partially within the opening. The spring portion of the electrical contact is engaged by the housing body such that the spring portion is deflected into shorting engagement with the intermediate portion of the electrical contact. | 01-22-2009 |
20090050358 | Electrical connector with elastomeric element - An electrical connector is provided. The electrical connector includes a substrate and an elastomeric element extending outwardly from the substrate. The elastomeric element extends outwardly from a base portion thereof at the substrate to an end portion thereof that is opposite the base portion. An electrical contact engages an electrically conductive element of the substrate. The electrical contact has a portion extending over at least a portion of the end portion of the elastomeric element. | 02-26-2009 |
20090075500 | Connector with dual compression polymer and flexible contact array - A socket connector includes an insulative carrier having opposite first and second sides and a plurality of vias extending between the first and second sides. A plurality of polymer columns is held by the carrier. Each polymer column includes a first end extending from the first side of the carrier and a second end extending from the second side of the carrier. A contact array is disposed on each first and second side of the carrier. Each contact array comprises a flexible sheet having a plurality of conductive elements having contact tips proximate corresponding first and second ends of the polymer columns. The conductive elements on the first side of the carrier are electrically connected to corresponding conductive elements on the second side of the carrier through the vias in the carrier to establish electrical paths between corresponding contact tips on the first and second sides of the carrier. | 03-19-2009 |
Keith Pennypacker, Wesley Chapel, FL US
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20110201688 | N,N'-DI-P-BROMOPHENYL GUANIDINE TREATMENT FOR STROKE AT DELAYED TIMEPOINTS - 1,3 di-o-tolylguanidine (DTG) was examined as anti-stroke drug with a broad therapeutic window. DTG activates sigma 1 and 2 receptors. Administration of DTG at 24 hours post-stroke to rats reduces neurodegeneration by 85%; this is the only pharmacological agent that has been used successfully at this delayed timepoint. Treatment with DTG provides protection of neurons exposed to hypoxia and blocks activation of immune cells that are responsible for delayed neurodegeneration associated with stroke. Disclosed is an altered DTG structure, placing a bromide at the para position to increase tissue penetrance and efficacy. Results show that N,N′-di-p-bromophenyl guanidine protects cultured neurons under hypoxic conditions but is more potent than DTG. Moreover, N,N′-di-p-bromophenyl guanidine is as least as efficacious as DTG in treating rats 24 hours after experimental stroke. | 08-18-2011 |
20150238502 | Compositions and Methods for Treating Stroke - Provided herein is a method of treating a subject believed to have suffered a stroke. This method comprises administering to the subject therapeutically effective amount of a composition comprising conivaptan or an active derivative, stereoisomer, pro-drug, or pharmaceutically acceptable salt thereof. | 08-27-2015 |
Keith R. Pennypacker, Wesley Chapel, FL US
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20140080885 | METHODS OF TREATING TRAUMATIC BRAIN INJURY - Embodiments of the present disclosure provide methods of treating a traumatic brain injury with an agent. In particular, embodiments of the present disclosure provide for methods of treating a traumatic brain injury using an agent such as (±)-[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl][2-(2-methoxyphenoxy)ethyl]amine or an isomer, a tautomer, or a prodrug thereof, or pharmaceutically acceptable salt each of these. | 03-20-2014 |
20150051291 | N,N'-DI-1 NAPHTHYLGUANIDINE HCL (NAGH) AND N,N'-DI-P-NITROPHENYLGUANIDINE HCL (NAD) TREATMENT FOR STROKE AT DELAYED TIMEPOINTS - A composition and method of treating stroke by administration of a novel sigma agonist is presented. Twenty-four hours after MCAO, systemic administration of several novel sigma agonists including: Bromo-DTG; Chloro-DTG; N,N′-di-1-Naphthylguanidine hydrochloride (NAGH); N,N′-di-p-Nitrophenylguanidine HCL (NAD) or vehicle were injected subcutaneously daily for 3 days. Rats treated with Bromo-DTG and Chloro-DTG had no significant improvements in any of the motor or cognitive tests while NAGH treated rats showed improved vertical movement and had significantly less motor asymmetry and bias than vehicle treated rats. Sigma receptor agonist NAGH also was found to exert its long-term neuroprotective effects by preserving both gray matter and white matter tracts. Both NAD and NAGH, when administered 24 hours after experimental stroke, reduced neural damage and enhanced behavioral recovery thirty days later which suggests that NAGH and NAD potentially extend the therapeutic window of stroke several fold over the current treatments. | 02-19-2015 |
Keith Ronald Pennypacker, Wesley Chapel, FL US
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20130129673 | USE OF ENDOGENOUS ANTIOXIDANT PROTEINS IN THE TREATMENT OF STROKE - Oligodendrocytes (OLs), the predominant cell type found in cerebral white matter, are essential for structural integrity and proper neural signaling. Very little is known concerning stroke-induced OL dysfunction. Infusion of human umbilical cord blood (HUCB) cells protects striatal white matter tracts in vivo and directly protects mature primary OL cultures from oxygen glucose deprivation (OGD). Microarray studies of RNA prepared from OL cultures subjected to OGD and treated with HUCB cells showed an increase in the expression of 33 genes associated with OL proliferation, survival, and repair functions, such as myelination. Immunohistochemistry showed antioxidant protein expression was upregluated in the ipsilateral white matter tracts of rats infused with HUCB cells 48 hrs after middle cerebral artery occlusion (MCAO). These results show expression of genes induced by HUCB cell therapy that could confer oligoprotection from ischemia. | 05-23-2013 |
20150030609 | DIAGNOSIS AND TREATMENT OF TRAUMATIC BRAIN INJURY - The subject invention identifies CC chemokine ligand 20 (CCL20) as a novel biomarker for diagnosis of traumatic brain injury and/or neurodegeneration in the brain. The subject invention also provides treatment methods for traumatic brain injury and/or neurodegeneration in the brain by modulating systemic and/or brain-specific CCL20-CCR6 signaling. Also provided are uses of CCL20-CCR6 signaling a target for screening for therapeutic agents that are useful for treatment of traumatic brain injury. | 01-29-2015 |
Rondell Pennypacker, Duncan, OK US
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20140262274 | OXIDATIVE BREAKERS IN A SILICONE BASED SUSPENSION - An oxidative breaker system for use in reducing the viscosity of a guar-based suspension includes a silicone oil carrier fluid, an oxidizer and a suspension aid. The suspension aid is preferably fumed silica. The oxidizer may be selected from the group consisting of alkali metal peroxide, transition metal peroxide, persulfate, bromide and bromate. In highly preferred embodiments, the oxidizer is magnesium peroxide or calcium peroxide. Also disclosed is a method for breaking a guar-based suspension with the inventive oxidative breaker system. | 09-18-2014 |
20140274822 | OXIDATIVE BREAKERS IN A SILICONE BASED SUSPENSION - An oxidative breaker system for use in reducing the viscosity of a polysaccharide-based or derivatized polysaccharide-based suspension includes a silicone carrier fluid, an oxidizer, and a suspension aid. The suspension aid is preferably fumed silica. The oxidizer may be selected from the group consisting of alkali metal peroxide, transition metal peroxide, persulfate compound, bromide compound, and bromate compound. In highly preferred embodiments, the oxidizer is magnesium peroxide or calcium peroxide. Alternative carrier fluids and suspension agents are also included in the art. Also disclosed is a method for breaking a polysaccharide-based suspension with the inventive oxidative breaker system. | 09-18-2014 |