Desimone, US
Alex Desimone, New York, NY US
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20140121592 | IRRIGATION ASSEMBLY - An assembly structured for concurrent irrigation and aspiration of a nasal cavity including a housing having a supply container disposed therein for the removable retention of irrigating fluid. A nasal applicator comprises first and second passages respectfully structured to deliver irrigating fluid to the nasal cavity and concurrently remove waste fluid therefrom. An activating assembly includes a plunger biased into a continuous pressure applying, dispensing relation to the irrigating fluid and a valve assembly is selectively disposable into an open position facilitating fluid communication between the supply container and the applicator for the delivery of the irrigating fluid therethrough into the nasal cavity. The activating assembly is further structured to create a negative pressure within the chamber which communicates with the second passage of the applicator to facilitate delivery of the waste fluid therefrom along a path of travel to an interior of the chamber. | 05-01-2014 |
Alex Desimone, Ft. Lauderdale, FL US
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20150224246 | NASAL IRRIGATION ASSEMBLY AND SYSTEM - An assembly for the handheld irrigation of a user's nasal cavity comprising a housing with a refill chamber containing irrigating fluid, an applicator, an actuator for forcing irrigating fluid from the refill chamber through the applicator into the user's nasal cavity during operation, and a solution port for refilling the refill chamber. Some embodiments of the present invention may further comprise a system for nasal irrigation that includes the assembly for nasal irrigation or handheld irrigator, as well as a solution assembly structured for dispensing irrigating fluid to the handheld irrigator, and a docking station for removably housing the handheld irrigator and solution assembly. | 08-13-2015 |
Andrea Desimone, Watertown, MA US
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20140086722 | RAM AIR FLAP SYSTEM - An assembly for increasing air flow to a vehicle cooling system includes a portion of a cooling fan shroud, the portion having a face defining an opening therethrough, and a plurality of support members extending from the face. A flap includes a plurality of apertures proximal to an edge. Each aperture of the plurality of apertures is formed to receive one of the plurality of support members for coupling the flap thereto. A clearance fit formed between the apertures and the support members permits movement of the flap from a first position generally parallel to the face to a second position in response to a flow of air. | 03-27-2014 |
Anthony G. Desimone, Everett, WA US
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20120137917 | LOW SHOCK ROCKET BODY SEPARATION - The present disclosure generally relates a high strength, low weight, and low shock rocket body separating joint for the purpose of joining rocket bodies, and method of assembly thereof The solution combines a radax joint, joined by fasteners, with a flattened bladder and inflation system coupled thereto. Upon activation of the inflation system, the bladder is pressurized and exerts a separating force between the members of the radax joint, overcoming the load carrying capability of the fasteners and breaking apart the radax joint. | 06-07-2012 |
Dennis Desimone, Escondido, CA US
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20120144108 | DATA PROTECTION SYSTEMS WITH MULTIPLE SITE REPLICATION - Systems and methods for replicating data from a first site to a second site remote from said first site are described. An embodiment includes storing compressed data on a hard disk appliance, reading said data without decompressing said data, sending said data over a wide-area-network (WAN) in a compressed state, and storing said data on a second hard disk appliance remote from said first hard disk appliance in its compressed state without performing an additional compression operation. | 06-07-2012 |
20130019074 | DATA PROTECTION SYSTEMS WITH MULTIPLE SITE REPLICATION - Systems and methods for replicating data from a first site to a second site remote from said first site are described. An embodiment includes storing compressed data on a hard disk appliance, reading said data without decompressing said data, sending said data over a wide-area-network (WAN) in a compressed state, and storing said data on a second hard disk appliance remote from said first hard disk appliance in its compressed state without performing an additional compression operation. | 01-17-2013 |
20150081995 | DATA PROTECTION WITH MULTIPLE SITE REPLICATION - Systems and methods for replicating data from a first site to a second site remote from said first site are described. An embodiment includes storing compressed data on a hard disk appliance, reading said data without decompressing said data, sending said data over a wide-area-network (WAN) in a compressed state, and storing said data on a second hard disk appliance remote from said first hard disk appliance in its compressed state without performing an additional compression operation. | 03-19-2015 |
Frank Desimone, Carlisle, MA US
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20120236028 | SYSTEMS AND METHODS FOR MERGING AND SPLITTING INTERSECTING SOLIDS AND SURFACES - Embodiments of the invention relate to merging and splitting intersecting geometry-only solids and surfaces in an intuitive manner. One embodiment is a method of merging and cutting geometry-only format CAD objects without related history information, using a single geometry modification tool and interface. In response to receiving a group selection from the user, of a plurality of CAD objects, the method infers a merge operation and automatically merges the plurality of CAD objects into a single merged CAD object. In response to receiving an individual selection from the user of a CAD object, the geometry modification tool enters a merged state when the subsequent second selection from the user is selected in a manner indicating a merger operation, or alternatively, enters a cut state when the subsequent second selection from the user is selected in a manner indicating a cut operation. | 09-20-2012 |
Frank Desimone, Henderson, NE US
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20120122545 | WAGERING GAME, GAMING MACHINE, GAMING NETWORK, AND METHODS INCLUDING A DYNAMIC WHEEL - A wagering game, gaming machine, gaming network, and associated methods are disclosed including a dynamic wheel wherein a wheel game includes re-programming the wheel display and associated awards during successive plays. The dynamic wheel may be displayed in a wheel display area of a flat panel display device. The wheel display area along with other display areas may be defined by a bezel positioned over the display surface of the flat panel display device. | 05-17-2012 |
20120122571 | TOP BOX WHEEL ASSEMBLY AND GAMING MACHINE HAVING A TOP BOX WHEEL ASSEMBLY - A top box wheel assembly and method are disclosed wherein a flat panel display is mounted on a rectangular shaped cabinet top box structure and a circular bezel structure overlays the flat panel display such that a wheel-shaped display area is provided. The circular bezel structure also is shown to include a rectangular cutout base to also provide a rectangular-shaped display area. The circular bezel structure is further shown to include a circular pattern of LEDs which may be operated synchronously or quasi-synchronously with the wheel-shaped display area on which a rotating wheel may be displayed together with an indicator. | 05-17-2012 |
Frank C. Desimone, Henderson, NV US
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20110269552 | BUTTON PANEL MOUNT FOR A GAMING MACHINE CABINET - A gaming machine cabinet has a cabinet door is pivotally connected thereto and movable between a closed and open positions. A cabinet door button panel includes a panel support surface opposite the door's inner side, a capture structure at a first boundary of a button panel opening, and a blocking structure at a button panel second boundary opposite the first boundary. A button panel base has a first edge received in a button panel frame capture structure, and second edge received on the panel support surface. A locking flange with a locking projection extends from the button panel base lower side, the locking projection moveable between extended and retracted positions. With the button panel base in an operating position, a locking projection may be placed in the extended position to contact the blocking structure and thereby retain the button panel base in the operating position. | 11-03-2011 |
20130035154 | GAMING SYSTEM, METHOD, AND PROGRAM PRODUCT WITH PAYTABLE ENHANCEMENTS - A method includes displaying a number of enhancement symbols concurrently on a display device included at a gaming machine through which a wagering game may be played. The wagering game has a paytable providing at least one award level correlated to a payout value. Each of the displayed enhancement symbols is correlated to a payout modification. At least one of these enhancement symbols is selected and shown on the display device as being selected for a given play of the wagering game. The payout modification correlated to the selected enhancement symbol is used to identify a modified payout value for the outcome generated and displayed graphically for play of the game. This modified payout value is awarded for the given play of the game in lieu of or in addition to the payout value shown in the paytable for the outcome. | 02-07-2013 |
Frank E. Desimone, Berlin, MA US
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20150362914 | BEAM TOOL PATHING FOR 3D COMPOUND CONTOURS USING MACHINING PATH SURFACES TO MAINTAIN A SINGLE SOLID REPRESENTATION OF OBJECTS - Computer based methods, systems, and techniques for planning and generating machining paths for a tool that manufactures a three dimensional object having beveled or “compound” contours from a workpiece. A computer aided design (CAD)/computer aided manufacturing (CAM) system creates intermediate machining path surfaces that extend based on a CAD solid model representing the geometry of the object to be manufactured. The intermediate machining path surfaces extend to a shape that simulates a cutting beam (e.g., a waterjet, a laser beam, etc.) of the tool. For a flat workpiece, the machining path surfaces may extend from a top surface of the workpiece, which is a tool beam entrance surface, to a bottom surface of the workpiece, which is a tool beam exit surface. An operator is able to visualize the cuts to be made and the actual finished object geometry, without requiring the creation of multiple CAD solid models. | 12-17-2015 |
Gaetano D. Desimone, Mansfield, MA US
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20120256148 | SECURITY ENCLOSURE - A security enclosure in accordance with the present disclosure includes several wall units. The wall units are connected to one another in series to form a closed space bounded by the interconnected wall units that serves as a play area for children and pets. | 10-11-2012 |
Gaetano D. Desimone, Peabody, MA US
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20110193382 | JUVENILE VEHICLE SEAT WITH ADJUSTABLE BASE - A child restraint includes an adjustable base for installation on a vehicle seat and a detachable infant carrier associated with the adjustable base. The base is configured to be adjusted to tilt the infant carrier relative to the vehicle seat. | 08-11-2011 |
Gaetano Daniel Desimone, Peabody, MA US
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20090243261 | JUVENILE STROLLER WITH REMOVABLE CHILD CARRIER - A multi-seat juvenile stroller including a first seat, second seat, and a rolling stroller frame. The second seat includes a mobile infant carrier. | 10-01-2009 |
George A. Desimone, Yorktown Heights, NY US
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20110188649 | VOIP DIAL PLAN ANALYSIS AND IMPROVEMENT BASED ON DESIGN PATTERNS - A computer implemented method that analyzes and improves a dial plan. A dial plan design template system receives an existing dial plan. The dial plan design template system models the existing dial plan as a directed graph. The dial plan design template system analyzes the directed graph to determine compliance with a set of edge rules. The dial plan design template system analyzes the directed graph to determine compliance with a set of connectivity type rules. | 08-04-2011 |
Joseph Desimone, Freehold, NJ US
Joseph Desimone, Chapel Hill, NC US
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20110123446 | DEGRADABLE COMPOUNDS AND METHODS OF USE THEREOF, PARTICULARLY WITH PARTICLE REPLICATION IN NON-WETTING TEMPLATES - The present invention provides compounds that will degrade under specified conditions, methods of using such compounds, and compositions comprising such compounds. The degradable compounds of the invention may be characterized by the labile —Si-A-C— groups present in the compounds (A representing an atom, such as O, N, or S, or a group, such as C═O). The compounds may be incorporated into a composition that further may include a polymeric matrix and/or a cargo component. A wide variety of cargo components may also be used in the present invention. In particular embodiments, the cargo component comprises a drug or other therapeutic agent. Accordingly, the invention particularly provides pharmaceutical formulations and methods of delivering a drug or other therapeutic material. | 05-26-2011 |
20110306878 | INTERVENTIONAL DRUG DELIVERY SYSTEM AND ASSOCIATED METHODS - A delivery system for local drug delivery to a target site of internal body tissue is provided. The delivery system comprises a source electrode adapted to be positioned proximate to a target site of internal body tissue. A counter electrode is in electrical communication with the source electrode, and is configured to cooperate with the source electrode to form a localized electric field proximate to the target site. A reservoir is configured to be disposed such that the reservoir is capable of interacting with the localized electric field. The reservoir is configured to carry a cargo capable of being delivered to the target site when exposed to the localized electric field. Associated methods are also provided. | 12-15-2011 |
20120259153 | DELIVERY SYSTEMS FOR BRACHYTHERAPY, AND ASSOCIATED METHODS - Delivery systems adapted for implementation during a brachytherapy procedure are provided. The delivery system includes a plurality of brachytherapy seeds and a plurality of spacers. Each spacer is formed of a matrix material carrying a plurality of microparticles and/or nanoparticles. The microparticles and/or nanoparticles carry an agent and are biodegradable and/or biocompatible. The brachytherapy seeds and the spacers are configured to be delivered to a target site. Associated methods are also provided. | 10-11-2012 |
20150037428 | GEOMETRICALLY ENGINEERED PARTICLES AND METHODS FOR MODULATING MACROPHAGE OR IMMUNE RESPONSES - Disclosed herein are geometrically engineered particles having varied shapes and sizes and surface charge which can incorporate drugs and/or other biomaterials for targeted delivery, such as pulmonary delivery. The size, shape, etc. of a particle can be designed and corresponding particles can be prepared that target or de-target immunological responses to the particles themselves, for example, the response of alveolar macrophages. Methods of modulating immune responses by utilizing the particles are also disclosed. The particles can be composed substantially of therapeutic, drug and polymer or can comprise polymers and proteins. The particles may also be composed of diagnostic agents and additional biomaterials to confer aerosolization and cellular uptake properties. The particles also may have a range of physical features such as fenestrations, angled arms, asymmetry and surface roughness, charge which alter the interactions with cells and tissues. | 02-05-2015 |
20150352777 | HIGH-THROUGHPUT MANUFACTURING OF MICRONEEDLES - The present invention provides a system for fabricating a microneedle device and microneedle devices. The system includes depositing a first material on a delivery sheet, introducing the delivery sheet with deposited first material to a mold, passing the delivery sheet with deposited first material and mold through a nip-point to introduce at least a portion of first material into cavities in the mold, and separating the mold from the first material to provide a microneedle device with needles mimicking the cavities of the mold. | 12-10-2015 |
20160022985 | INTERVENTIONAL DRUG DELIVERY SYSTEM AND ASSOCIATED METHODS - A delivery system for local drug delivery to a target site of internal body tissue is provided. The delivery system comprises a source electrode adapted to be positioned proximate to a target site of internal body tissue. A counter electrode is in electrical communication with the source electrode, and is configured to cooperate with the source electrode to form a localized electric field proximate to the target site. A reservoir is configured to be disposed such that the reservoir is capable of interacting with the localized electric field. The reservoir is configured to carry a cargo capable of being delivered to the target site when exposed to the localized electric field. Associated methods are also provided. | 01-28-2016 |
Joseph Desimone, Glen Ellyn, IL US
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20110287092 | COMPOSITIONS COMPRISING DECITABINE AND TETRAHYDROURIDINE AND USES THEREOF - Compositions comprising decitabine and tetrahydrouridine for the treatment of blood disorders and hematological and solid malignancies are described. | 11-24-2011 |
20120225836 | COMPOSITIONS COMPRISING DECITABINE AND TETRAHYDROURIDINE AND USES THEREOF - Embodiments of compositions and methods for the treatment of blood disorders and malignancies in a subject are described herein. In one embodiment, a composition for the treatment of a blood disorder or a malignancy in a subject comprises decitabine, tetrahydrouridine, and an excipient. In another embodiment, a method for the treatment of a blood disorder or a malignancy in a subject comprises the oral administration of a composition comprising decitabine and tetrahydrouridine. In some examples, the composition may be administered 1-3 times weekly. | 09-06-2012 |
Joseph M. Desimone, Durham, NC US
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20090023038 | LIQUID MATERIALS FOR USE IN ELECTROCHEMICAL CELLS - Disclosed is the use of liquid precursor materials to prepare a processible polymeric electrolyte, which can be used to form a proton exchange membrane for use in an electrochemical cell. Also disclosed is the use of liquid precursor materials to prepare a processible catalyst ink composition, which can be conformally applied to a proton exchange membrane and a electrode material for use in an electrochemical cell. Also disclosed is the use of a photocurable perfluoropolyether (PFPE) material to form a microfluidic electrochemical cell. | 01-22-2009 |
Joseph M. Desimone, Los Gatos, CA US
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20150097315 | CONTINUOUS LIQUID INTERPHASE PRINTING - A method of forming a three-dimensional object, comprises providing a carrier and an optically transparent member having a build surface, the carrier and the build surface defining a build region therebetween; filling the build region with a polymerizable liquid; irradiating the build region through the optically transparent member to form a solid polymer from the polymerizable liquid while concurrently advancing the carrier away from the build surface to form the three-dimensional object from the solid polymer, while also concurrently: (i) continuously maintaining a dead zone of polymerizable liquid in contact with the build surface, and (ii) continuously maintaining a gradient of polymerization zone between the dead zone and the solid polymer and in contact with each thereof, the gradient of polymerization zone comprising the polymerizable liquid in partially cured form. Apparatus for carrying out the method is also described. | 04-09-2015 |
20150097316 | METHOD AND APPARATUS FOR THREE-DIMENSIONAL FABRICATION WITH FEED THROUGH CARRIER - A method of forming a three-dimensional object, is carried out by (a) providing a carrier and a build plate, the build plate comprising a semipermeable member, the semipermeable member comprising a build surface with the build surface and the carrier defining a build region therebetween, and with the build surface in fluid communication by way of the semipermeable member with a source of polymerization inhibitor; (b) filling the build region with a polymerizable liquid, the polymerizable liquid contacting the build surface; (c) irradiating the build region through the build plate to produce a solid polymerized region in the build region, while forming or maintaining a liquid film release layer comprised of the polymerizable liquid formed between the solid polymerized region and the build surface, the polymerization of which liquid film is inhibited by the polymerization inhibitor; and (d) advancing the carrier with the polymerized region adhered thereto away from the build surface on the build plate to create a subsequent build region between the polymerized region and the build surface; (e) wherein the carrier has at least one channel formed therein, and the filling step is carried out by passing or forcing the polymerizable liquid into the build region through the at least one channel. Apparatus for carrying out the method is also described | 04-09-2015 |
20150102532 | METHOD AND APPARATUS FOR THREE-DIMENSIONAL FABRICATION - A method of forming a three-dimensional object, is carried out by (a) providing a carrier and a build plate, the build plate comprising a semipermeable member, the semipermeable member comprising a build surface with the build surface and the carrier defining a build region therebetween, and with the build surface in fluid communication by way of the semipermeable member with a source of polymerization inhibitor; (b) filling the build region with a polymerizable liquid, the polymerizable liquidcontacting the build surface, (c) irradiating the build region through the build plate to produce a solid polymerized region in the build region, while forming or maintaining a liquid film release layer comprised of the polymerizable liquid formed between the solid polymerized region and the build surface, wherein the polymerization of which liquid film is inhibited by the polymerization inhibitor; and (d) advancing the carrier with the polymerized region adhered thereto away from the build surface on the build plate to create a subsequent build region between the polymerized region and the build surface while concurrently filling the subsequent build region with polymerizable liquid as in step (b). Apparatus for carrying out the method is also described. | 04-16-2015 |
20150288028 | ION CONDUCTING POLYMERS AND POLYMER BLENDS FOR ALKALI METAL ION BATTERIES - Electrolyte compositions for batteries such as lithium ion and lithium air batteries are described. In some embodiments the compositions are liquid compositions comprising (a) a homogeneous solvent system, said solvent system comprising a perfluropolyether (PFPE) and polyethylene oxide (PEO); and (b) an alkali metal salt dissolved in said solvent system. In other embodiments the compositions are solid electrolyte compositions comprising: (a) a solid polymer, said polymer comprising a crosslinked product of a crosslinkable perfluropolyether (PFPE) and a crosslinkable polyethylene oxide (PEO); and (b) an alkali metal ion salt dissolved in said polymer. Batteries containing such compositions as electrolytes are also described. | 10-08-2015 |
Mark Desimone, Westbrook, CT US
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20110011327 | ADJUSTABLE PIVOTING HANGER - A hanger for retaining a portion of line associated with watercraft is disclosed. The hanger comprises a tower, an arm extending outwardly from the tower and coupled for pivotal rotation thereto. A dampening mechanism is mounted to the tower and coupled to the arm. The dampening mechanism retards the pivotal movement of the arm relative to the tower. Furthermore, a cleat is coupled to the arm at a distal end thereof. | 01-20-2011 |
Michael J. Desimone, Ridgefield, CT US
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20100238285 | IDENTIFYING SPATIAL LOCATIONS OF EVENTS WITHIN VIDEO IMAGE DATA - An invention for identifying a spatial location of an event within video image data is provided. In one embodiment, there is a spatial representation tool, including a compression component configured to receive trajectory data of an event within video image data, and generate a set of compressed spatial representation of the trajectory data of the event within the video image data. A database component is configured to input the set of compressed spatial representations into a relational database, and a search component is configured to search the relational database to identify a spatial location of the event within the video image data. | 09-23-2010 |
20100239016 | CODING SCHEME FOR IDENTIFYING SPATIAL LOCATIONS OF EVENTS WITHIN VIDEO IMAGE DATA - An invention for generating a coding schema for identifying a spatial location of an event within video image data is provided. In one embodiment, there is a spatial representation tool, including a compression component configured to receive trajectory data of an event within video image data, generate a lossless compressed contour-coded blob to encode the trajectory data of the event within video image data, and generate a lossy searchable code to enable searching of a relational database based on the trajectory data of the event within the video image data. | 09-23-2010 |
20130259316 | IDENTIFYING SPATIAL LOCATIONS OF EVENTS WITHIN VIDEO IMAGE DATA - An invention for identifying a spatial location of an event within video image data is provided. Disclosed are embodiments for generating trajectory data of a trajectory of an object for a plurality of pixel regions of an area of interest within video image data, the generating comprising: identifying one or more pixel regions from the plurality of pixel regions containing trajectory data; performing a multi-point neighborhood scan within the one or more pixel regions from the plurality of pixel regions containing trajectory data; and generating a transition chain code based on the multi-point neighborhood scan. Embodiments further generate a set of compressed spatial representations of the trajectory data of the trajectory of the object for an event based on the transition chain code, and generate a lossless contour code of the trajectory data of the trajectory of the object for the event based on the transition chain code. | 10-03-2013 |
20140028845 | CODING SCHEME FOR IDENTIFYING SPATIAL LOCATIONS OF EVENTS WITHIN VIDEO IMAGE DATA - An approach for generating a coding schema for identifying a spatial location of an event within video image data is provided. In one embodiment, there is a spatial representation tool, including a compression component configured to receive trajectory data of a trajectory of an object for an event within video image data; generate a lossless compressed contour-coded blob to encode the trajectory data of the trajectory of the object for the event within video image data; generate a lossy searchable code of the trajectory of the object for the event within the video image data; convert a region of interest within the video image data to a lossy query code, the region of interest corresponding to a sub-section of a visual display output of the video image data; and compare the lossy query code to the lossy searchable code within a relational database to identify a corresponding lossless trajectory data of the trajectory of the object for the event within the video image data. | 01-30-2014 |
20150161453 | IDENTIFYING SPATIAL LOCATIONS OF EVENTS WITHIN VIDEO IMAGE DATA - An invention for identifying a spatial location of an event within video image data is provided. Disclosed are embodiments for detecting an object and obtaining trajectory data of a trajectory of the object within the video image data from a sensor device; converting the trajectory data into a contour-coded compressed image; generating, based on the trajectory data, a searchable code that contains a set of locations traversed by the trajectory of the object within the video image; associating the searchable code with the contour-coded compressed image in a database; and returning, in response to a query having a selected location that corresponds a location of the set of locations in the searchable code, an image of the trajectory data corresponding to the object based on the contour-coded compressed image in the database. | 06-11-2015 |
Nathaniel L. Desimone, Portland, OR US
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20150092828 | APPARATUS, SYSTEM, AND METHOD FOR IMPROVING EQUALIZATION WITH A SOFTWARE EQUALIZATION ALGORITHM - A system and method consistent with the present disclosure includes determining a jitter tolerance of a particular lane of a communication link corresponding to each of a plurality of equalization coefficients. Further, determining a particular equalization coefficient of the plurality of equalization coefficients that provides a maximum jitter tolerance. Next, using the particular equalization coefficient for the particular lane of the communication link during operation based on determining the particular equalization coefficient which provides the maximum jitter tolerance. | 04-02-2015 |
20150277935 | TECHNIQUES FOR ADAPTIVE INTERFACE SUPPORT - Techniques for adaptive interface support are described. In one embodiment, for example, an apparatus may comprise logic, at least a portion of which is in hardware, the logic to execute a basic input/output system (BIOS), determine a respective impedance state for each of one or more pins in an M.2 physical interface, determine an interface type for a peripheral device coupled with the M.2 physical interface based on the impedance states for the one or more pins, and control an operational state of the peripheral device during execution of the BIOS, based on the interface type for the peripheral device. Other embodiments are described and claimed. | 10-01-2015 |
Philip Desimone, Chapel Hill, NC US
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20120114554 | Engineered Aerosol Particles, And Associated Methods - An engineered aerosol particle for use in aerosol applications is provided. The engineered aerosol particle comprises a fabricated nanoparticle body member being non-spherical. The fabricated nanoparticle body member is configured to provide at least one of auto-rotation, tumbling, or lift when entrained in an airstream to thereby increase settling time of the fabricated nanoparticle body member. An associated method is also provided. | 05-10-2012 |
20130346153 | PRODUCTS OR SERVICES DEMAND ANALYTICS SYSTEMS AND RELATED METHODS AND ELECTRONIC EXCHANGES - Products or services demand analytics systems are provided. The systems may include a processor configured to determine whether to make an offer from a buyer to purchase a product or service at a buyer-determined price available to a seller of the product or service, based on a demand analytics preference of the seller for the product or service. Moreover, the processor may be configured to adjust whether the offer is made available to the seller and/or how the offer is communicated to the seller in response to an adjustment by the seller of the demand analytics preference for the product or service. Related methods and electronic exchanges are also described. | 12-26-2013 |
20130346248 | METHODS AND ELECTRONIC EXCHANGES FOR FACILITATING A BUYER-DRIVEN TRANSACTION - Methods and electronic exchanges that facilitate buyer-driven transactions are provided. The methods may include receiving at an electronic exchange an offer from a buyer to purchase a product or service at a buyer-determined price. The methods may also include searching seller inventory data or seller capacity data from at least one database to match the offer with at least one seller inventory or seller schedule that includes the product or service. The methods may further include receiving at the electronic exchange an acceptance of the offer from an individual seller whose inventory or schedule is included among the at least one seller inventory or seller schedule. Related electronic exchanges are also described. | 12-26-2013 |
20160030346 | ENGINEERED AEROSOL PARTICLES, AND ASSOCIATED METHODS - An engineered aerosol particle for use in aerosol applications is provided. The engineered aerosol particle comprises a fabricated nanoparticle body member being non-spherical. The fabricated nanoparticle body member is configured to provide at least one of auto-rotation, tumbling, or lift when entrained in an airstream to thereby increase settling time of the fabricated nanoparticle body member. An associated method is also provided. | 02-04-2016 |
Robert Desimone, Brookline, MA US
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20150320560 | RADIOLUCENT CRANIAL IMPLANTS FOR NEURAL APPLICATIONS - Cranial implants, kits including cranial implants, and methods of making cranial implants are described. The cranial implants may be radiolucent. The cranial implants may have contact surfaces complementary in shape to measured portions of a surface of a specific cranium. The radiolucent cranial implants may include carbon-PEEK. | 11-12-2015 |
Robert W. Desimone, Durham, CT US
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20090082362 | Use of capsaicin receptor antagonists to treat symptoms of tear gas exposure - Disclosed are diaryl piperazines and related compounds. These compounds are selective modulators of capsaicin receptors, including human capsaicin receptors, that are, therefore, useful in the treatment of a chronic and acute pain conditions, itch and urinary incontinence. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of capsaicin receptors and as standards in assays for capsaicin receptor binding and capsaicin receptor mediated cation conductance. Methods of using the compounds in receptor localization studies are given. | 03-26-2009 |
20110177011 | CERTAIN IMIDAZO[1,2-A]PYRAZIN-8-YLAMINES AND METHOD OF INHIBITION OF BRUTON'S TYROSINE KINASE BY SUCH COMPOUNDS - Compounds of Formula I-a | 07-21-2011 |
Salvatore Desimone, Bridgeport, PA US
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20090047533 | COMPOSITION AND METHOD FOR TREATING FIBROUS MATERIALS - Compositions useful in preventing fungal and bacterial growth in fibrous substrates, e.g., paper, are provided. These compositions also advantageously do not corrode metal substrates that are attached and/or adjacent to the fibrous substrate. The compositions contain didecyl dimethyl ammonium bicarbonate and didecyl dimethyl ammonium carbonate (DDABC), a water-soluble cationic salt of ethylene diamine tetraacetic acid, optionally water, and optionally an agent which complexes said water-soluble cationic salt of ethylene diamine tetraacetic acid. Also provided are products containing these compositions and methods of using the same. | 02-19-2009 |
Salvatore A. Desimone, Southwick, MA US
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20130212432 | SYSTEMS, METHODS, AND APPARATUS FOR FACILITATING CLAIMS PROCESSING - Systems, apparatus, methods, and articles of manufacture provide for facilitating upload of one or more electronic files from a user device to a remote server. In some embodiments, a background upload process manages connectivity of the user device to the remote server and staging file uploads in a disconnected mode for automatic processing when connectivity is restored. | 08-15-2013 |
20150288486 | SYSTEMS, METHODS, AND APPARATUS FOR FACILITATING CLAIMS PROCESSING - Systems, apparatus, methods, and articles of manufacture provide for facilitating upload of one or more electronic files from a user device to a remote server. In some embodiments, a background upload process manages connectivity of the user device to the remote server and staging file uploads in a disconnected mode for automatic processing when connectivity is restored. | 10-08-2015 |
Steve Desimone, Bluffton, SC US
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20160031353 | TAILGATE WITH INTEGRATED LOADING RAMP SYSTEM - A cargo bed tailgate may include an extension configurable between a plurality of positions to enable oversized cargo to be securely carried on a cargo bed as well accommodate a deployable set of loading ramps which are storable within the tailgate and deployable to attach to the cargo bed extension after the cargo bed extension is moved and locked for the loading and unloading of a payload into or out of the cargo bed of the vehicle. | 02-04-2016 |