Fitz, MA
Lori Fitz, Somerville, MA US
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20100086516 | CYTOKINE RECEPTOR CHAIN - Polynucleotides encoding the IL-13 receptor and fragments thereof are disclosed. IL-13 receptor proteins, methods for their production, inhibitors of binding of IL-13 and its receptor and methods for their identification are also disclosed. Methods of medical treatment using such molecules and antagonists of the IL-13/IL-13R interaction are also provided. | 04-08-2010 |
Lori J. Fitz, Somerville, MA US
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20090010942 | NOVEL PRIMATE CHITINASES AND USES THEREFOR - Novel primate chitinases (pNC) and nucleic acids encoding these chitinases are disclosed. The pNCs of the invention are homologous to human acidic mammalian chitinases (hAMCase) and human chitotriosidase, in terms of their exon/intron genomic structure and conserved catalytic sites. The polypeptides and nucleic acids of the invention can be used to develop, and/or screen for, modulators of chitinase-activities, e.g., antisense, antibodies, RNAi. The modulators identified using methods and reagents disclosed herein can be used to reduce chitinase-associated inflammatory conditions. | 01-08-2009 |
20090156421 | ASSAYS AND METHODS FOR EVALUATING MULTIMERIC COMPLEXES - Assays, e.g., homogenous assays, and methods for identifying, quantifying and/or monitoring the formation and/or stability of a multimeric complex, e.g., a ternary complex are disclosed. The methods and assays of the invention can be used to identify and/or evaluate agents (e.g., proteins, peptides, antibody molecules, and small and large molecules) that interfere with and/or inhibit the formation of a multimeric complex (e.g., a ternary complex) or that disrupt a previously formed complex. | 06-18-2009 |
20100129360 | ANTIBODIES AGAINST HUMAN INTERLEUKIN-13 AND USES THEREFOR - This application relates to antibodies, e.g., humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in diagnosing, preventing, and/or treating a subject, e.g., a human patient, one or more IL-13-associated disorders, e.g., respiratory disorders (e.g., asthma); atopic disorders (e.g., allergic rhinitis); inflammatory and/or autoimmune conditions of the skin (e.g., atopic dermatitis), and gastrointestinal organs (e.g., inflammatory bowel diseases (IBD)), as well as fibrotic and cancerous disorders. | 05-27-2010 |
Wolfgang Fitz, Sheborn, MA US
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20100281678 | Surgical Tools Facilitating Increased Accuracy, Speed and Simplicity in Performing Joint Arthroplasty - Disclosed herein are tools for repairing articular surfaces repair materials and for repairing an articular surface. The surgical tools are designed to be customizable or highly selectable by patient to increase the speed, accuracy and simplicity of performing total or partial arthroplasty. | 11-11-2010 |
Wolfgang Fitz, S. Natick, MA US
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20100125338 | BONE PROTECTOR, KIT AND METHOD - A surgical kit includes an orthopaedic implant, an orthropaedic trial and a bone protector. All three components have bone-contacting surfaces sized and shaped to be placed against a resected bone surface. The orthopaedic implant and trial are thicker than the bone protector. The bone protector has a flat bearing surface while the implant and trial have curved articulating surfaces. In use, the bone protector is temporarily mounted on the resected bone surface to cover and protect the resected bone surface while other bones of the joint are resected. A retractor can be placed against the bone protector and used as a lever to move other bones of the joint for greater access during surgery. The bone protector serves as the fulcrum of the lever and protects the resected bone from damage. The kit, bone protector and method should be useful in minimally invasive total joint arthroplasty. | 05-20-2010 |
20120136451 | BONE PROTECTOR, KIT AND METHOD - A surgical kit includes an orthopaedic implant, an orthropaedic trial and a bone protector. All three components have bone-contacting surfaces sized and shaped to be placed against a resected bone surface. The orthopaedic implant and trial are thicker than the bone protector. The bone protector has a flat bearing surface while the implant and trial have curved articulating surfaces. In use, the bone protector is temporarily mounted on the resected bone surface to cover and protect the resected bone surface while other bones of the joint are resected. A retractor can be placed against the bone protector and used as a lever to move other bones of the joint for greater access during surgery. The bone protector serves as the fulcrum of the lever and protects the resected bone from damage. The kit, bone protector and method should be useful in minimally invasive total joint arthroplasty. | 05-31-2012 |
Wolfgang Fitz, Natick, MA US
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20080208348 | Apparatus and Method for Shoulder Arthroplasty - A glenoid prosthesis can include a bearing shell for accommodating the head of the humerus and a stem extending at an angle from a reverse face of the shell so as to engage the stem within a canal in the lateral border of the scapula for anchoring the glenoid prosthesis to the scapula. The prosthesis can be one piece or modular, where the shell and stem can be chosen from a plurality of shapes and sizes to most closely match the natural anatomy of the joint. A fastening means can attach the shell to the stem and a wearing surface can be secured to the face of the shell. The stem can be sized slightly larger than the canal and forcibly inserted into the canal to anchor the glenoid prosthesis to the scapula. Flutes, barbs, threads, etc. on the stem can further secure the stem within the canal. | 08-28-2008 |
20090307893 | Surgical Tools Facilitating Increased Accuracy, Speed and Simplicity in Performing Joint Arthroplasty - Disclosed herein are tools for repairing articular surfaces repair materials and for repairing an articular surface. The surgical tools are designed to be customizable or highly selectable by patient to increase the speed, accuracy and simplicity of performing total or partial arthroplasty. | 12-17-2009 |