Patent application number | Description | Published |
20090020710 | SEMICONDUCTOR NANOCRYSTALS FOR TIME DOMAIN OPTICAL IMAGING - A method of performing high repetition rate laser time domain imaging employs as fluoroprobes semiconductor nanocrystals having a fluorescence lifetime less than the laser pulse separation, typically less than 5 ns. The nanocrystals of the invention have a core/shell structure and may be surface treated to increase radiative decay. CdSe/Zns nanocrystals are particularly suitable. | 01-22-2009 |
20090047300 | BLOOD-BRAIN BARRIER EPITOPES AND USES THEREOF - The invention features a method of identifying an agent and generating an antibody that can cross the blood bram barrier, through the use of novel antigen isoforms of transmembrane domain protein 30A (TMEM30A) This is useful in establishing mechanisms of transmigration across the blood-bram barrier. These antigens are enriched in bram endothelium compared to other endothelial cells and may have better selectivity and capacity for bram delivery compared to transferrin and insulin receptors One antigen is TMEM30A. | 02-19-2009 |
20090233357 | Targeted Delivery of Compounds Using Multimerization Technology - There is disclosed herein subunits and multimers of subunits suitable for use in inducing the transport of one or more cargo substances into a cell and in some instances across a cell. The subunits may have a targeting domain such a antibody or antibody fragment, a multimerization domain, such as a verotoxin B-subunit mutant scaffold, and a cargo molecule such as a drug or imaging agent, which may be directly linked to the subunit or may be packaged in a liposome, nanoparticle, or the like. In some instances the targeting domain may have affinity for a blood-brain barrier antigen and may be capable of inducing cell mediated transcytosis to facilitate delivery of the cargo molecule across the blood-brain barrier. In some instances the targeting region may have affinity for a cancer antigen and may be capable of inducing cell-mediated endocytosis. | 09-17-2009 |
20110097739 | BLOOD-BRAIN BARRIER EPITOPES AND USES THEREOF - The invention features a method of identifying an agent and generating an antibody that can cross the blood brain barrier, through the use of novel antigen isoforms of transmembrane domain protein 30A (TMEM30A). This is useful in establishing mechanisms of transmigration across the blood-brain barrier. These antigens are enriched in brain endothelium compared to other endothelial cells and may have better selectivity and capacity for brain delivery compared to transferrin and insulin receptors. One antigen is TMEM30A. | 04-28-2011 |
20130034572 | COMPOSITIONS AND METHODS FOR BRAIN DELIVERY OF ANALGESIC PEPTIDES - The present invention relates to non-invasive brain delivery technology for centrally-acting analgesic peptides. Specifically, the invention is directed to compounds comprising an antibody or fragment thereof capable of transmigrating across the blood brain barrier (BBB) and an analgesic peptide. Compositions and methods of using the compounds or compositions are also provided. | 02-07-2013 |