Patent application number | Description | Published |
20080208198 | Osteochondral Implant Procedure and Device - A surgical procedure according to which a slotted film is positioned over an area of a bone to be milled; and a portion of a milling assembly is inserted in the defect, with another portion of the assembly extending through one of the slots so that the slot can be used as a guide to mill the bone. | 08-28-2008 |
20080234540 | Osteochondral Implant Procedure - A surgical procedure according to which a moldable material is positioned over a defect and over an area of the anatomy surrounding the defect so that the moldable material takes the shape of the area. After the moldable material forms a mold, a graft is placed on the mold; and cut to conform to a dimension of the defect. | 09-25-2008 |
20080292599 | Chondrogenic Compositions and Methods of Use - The invention provides a method of treatment joint and disk disease comprising administering to the subject in need thereof a novel composition comprising a substantially purified plurality of cells enhanced with at least one bioactive factor capable of causing at least a portion of the plurality of cells to express an increased amount of at least one chondrogenic marker. | 11-27-2008 |
20080306608 | OSTEOCHONDRAL PLUG GRAFT, KIT AND METHOD - Each of an osteochondral plug graft and a kit comprises a trapezoid shaped construct configured for osteochondral implanting. An osteochondral regeneration method comprises forming a recipient socket in a chondral area of an articular joint in need of repair; harvesting a trapezoid shaped graft from another chondral area; and implanting the trapezoid shaped graft into the recipient socket. | 12-11-2008 |
20090017438 | METHODS AND COMPOSITIONS FOR THE PRESERVATION OF CELLS AND TISSUES - Disclosed are methods for the preservation and storage of living biological tissues, organs, and populations of isolated cells. Also disclosed are compositions and methods to permit biological samples (including e.g., cells, cell cultures, tissues, and organs) to be harvested from suitable donor animals, stored for prolonged periods under refrigerated, cryogenic, or near-freezing, and then transported and implanted into a site within the body of a selected recipient animal, all without significant loss of cellular viability, tissue integrity, and/or biochemical function of the stored biological sample. | 01-15-2009 |
20090017439 | COMPOSITIONS AND METHODS FOR ENHANCING THE VIABILITY OF ANIMAL CELLS, TISSUES, AND ORGAN EXPLANTS - Disclosed are compositions and methods for the preservation, storage, and transport of living biological tissues, organs, and populations of isolated cells. In particular, the disclosed compositions and processes permit mammalian cells, tissues, and organs to be harvested from suitable donor animals, stored for prolonged periods, and transported to the site of recipient implantation, all without significant loss of cell viability, biological activity, and/or tissue integrity. | 01-15-2009 |
20090035250 | Compositions and methods for treating cavity conditions - Compositions, methods and kits to be used as a lubricant and for treatment of a cavity pathology including joint pathology are provided. The composition comprises therapeutically effective amounts of at least one bioactive agent, such as magnesium compound, at least one lubricating agent, such as hyaluronic acid, and at least one cell membrane repairing agent, such as polyethylene glycol. The components of these compositions may be administered by a direct application, an application through a cannula, an intra-articular injection, as a flush fluid during an arthroscopy of the affected area, as a post-arthroscopy injection, or as part of a lavage of the area affected by the intra-articular pathology. In addition, the composition of the present invention may be administered to the patient from a pump or a depot. | 02-05-2009 |
20090105117 | STEM CELLS AND LIM MINERALIZATION PROTEINS - Methods of changing a phenotype of a cell are provided. The methods comprise increasing an amount of an amino acid sequence which is at least 70% identical to an amino acid sequence encoding an LMP protein or a fragment thereof in a cell. The cells may be contacted by either a composition comprising a nucleic acid sequence encoding the amino acid sequence which is at least 70% identical to the amino acid sequence encoding an LMP or its fragment or by a composition comprising acid sequence which is at least 70% identical to the amino acid sequence encoding an LMP or its fragment or any combination thereof. The cells may be contacted either in vivo or ex-vivo. | 04-23-2009 |
20090110637 | LMP and Regulation of Tissue Growth - Novel methods are provided for changing cell phenotype, comprising a method of changing a phenotype of a target cell comprising: increasing an amount of an amino acid sequence in a source cell, wherein the source cell is located within a volume of a media and wherein the amino acid sequence is selected from the group consisting of LMP-1 protein, an LMP-2 protein, an LMP-3 protein, an LMP-1s protein, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7 or combination thereof; collecting at least a portion of the volume of the media; and contacting the target cell with at least the portion of the media. | 04-30-2009 |
20090319051 | OSTEOCHONDRAL PLUG GRAFT, KIT AND METHOD - Each of an osteochondral plug graft and a kit comprises a trapezoid shaped construct configured for osteochondral implanting. An osteochondral regeneration method comprises forming a recipient socket in a chondral area of an articular joint in need of repair; harvesting a trapezoid shaped graft from another chondral area; and implanting the trapezoid shaped graft into the recipient socket. | 12-24-2009 |
20100111829 | FLOWABLE COMPOSITION THAT HARDENS ON DELIVERY TO A TARGET TISSUE SITE BENEATH THE SKIN - Flowable compositions and methods are provided for delivering a therapeutic agent at or near a target tissue site beneath the skin of a patient, the flowable composition comprising (i) a solvent and (ii) an effective amount of the therapeutic agent, the flowable composition being capable of hardening to form a drug depot at a physiological temperature or as solvent contacts bodily fluid at or near the target tissue site, wherein the drug depot is capable of releasing the therapeutic agent over a period of at least one day and the target tissue site comprises at least one muscle, ligament, tendon, cartilage, spinal disc, spinal foraminal space near the spinal nerve root, facet or synovial joint, or spinal canal. In some embodiments, an implantable drug depot for delivering a therapeutic agent is provided, the implantable drug depot comprising (i) a chamber; and (ii) a flowable composition comprising an effective amount of a therapeutic agent disposed within the chamber of the drug depot, the flowable composition capable of hardening when the drug depot is delivered at or near the target tissue site. | 05-06-2010 |
20100129415 | BONE REGENERATION DEVICE - This invention is directed to a bone regeneration device including fascia and demineralized bone matrix mixed at a temperature not exceeding about 40° C. and lyophilized into the bone regeneration device, methods of preparing such a bone regeneration device and methods of treating bone defects using such a bone regeneration device. | 05-27-2010 |
20100209470 | DEMINERALIZED BONE MATRIX DEVICES - The invention relates to a sheet-form demineralized bone matrix (DBM) composition comprising an aqueous admixture of DBM particles, starch and gelatin, wherein the DBM particles are present in an amount of between about 30% and about 70% by weight, the gelatin is present in an amount between about 10 and about 40% by weight and the starch is present in an amount between about 5% and about 20% by weight, wherein the DBM particles are retained in the form of the resilient sheet. | 08-19-2010 |
20100209474 | MALLEABLE IMPLANTS CONTAINING DEMINERALIZED BONE MATRIX - Described are malleable medical compositions such as pastes or putties that include solids combined with a liquid carrier. The solids include particulate collagen and particulate demineralized bone matrix. The liquid carrier includes an aqueous medium comprising a polysaccharide. Also described are methods for making and using such medical compositions. | 08-19-2010 |
20100297255 | MALLEABLE IMPLANTS CONTAINING DEMINERALIZED BONE MATRIX - Described are malleable medical compositions such as pastes or putties that include solids combined with a liquid carrier. The solids include particulate collagen and particulate demineralized bone matrix. The liquid carrier includes an aqueous medium comprising a polysaccharide. Also described are methods for making and using such medical compositions. | 11-25-2010 |
20100312173 | Devices and Methods for Delivering Medical Agents - Described are novel methods for delivering a medical agent to a plurality of locations within a patient tissue volume such as the interior space of a spinal disc, and also for removing material therefrom during medical agent delivery to enhance the delivery. Also described are medical delivery devices such as needle assemblies configured to facilitate the regional delivery of medical agents to patient tissue. | 12-09-2010 |
20110065083 | Compositions and Methods for Enhancing the Viability of Animal Cells, Tissues, and Organ Explants - Disclosed are compositions and methods for the preservation, storage, and transport of living biological tissues, organs, and populations of isolated cells. In particular, the disclosed compositions and processes permit mammalian cells, tissues, and organs to be harvested from suitable donor animals, stored for prolonged periods, and transported to the site of recipient implantation, all without significant loss of cell viability, biological activity, and/or tissue integrity. | 03-17-2011 |
20110104233 | FLOWABLE COMPOSITION THAT SETS TO A SUBSTANTIALLY NON-FLOWABLE STATE - Flowable compositions and methods are provided for delivering a therapeutic agent at or near a target tissue site beneath the skin of a patient, the flowable composition comprising (i) a solvent, (ii) a polymer and (iii) an effective amount of the therapeutic agent, the flowable composition being capable of setting to form a substantially non-flowable composition at a physiological temperature or as the solvent contacts bodily fluid at or near the target tissue site, wherein the substantially non-flowable composition is capable of releasing the therapeutic agent over a period of at least one day and the target tissue site comprises at least one muscle, ligament, tendon, cartilage, spinal disc, spinal foraminal space near the spinal nerve root, facet or synovial joint, or spinal canal. | 05-05-2011 |
20110143331 | Methods and Compositions for the Preservation of Cells and Tissues - Disclosed are methods for the preservation and storage of living biological tissues, organs, and populations of isolated cells. Also disclosed are compositions and methods to permit biological samples (including e.g., cells, cell cultures, tissues, and organs) to be harvested from suitable donor animals, stored for prolonged periods under refrigerated, cryogenic, or near-freezing, and then transported and implanted into a site within the body of a selected recipient animal, all without significant loss of cellular viability, tissue integrity, and/or biochemical function of the stored biological sample. | 06-16-2011 |
20110182849 | COMPOSITIONS AND METHODS FOR TREATING AN INTERVERTEBRAL DISC USING BULKING AGENTS OR SEALING AGENTS - Effective compositions and methods for treating an intervertebral disc are provided. The compositions and methods comprise a bulking agent or sealing agent, the bulking agent or sealing agent adapted to be administered at or within the intervertebral disc, the bulking or sealing agent having a drug depot comprising an effective amount of a therapeutic agent disposed therein, wherein the drug depot is capable of releasing an effective amount of the therapeutic agent over a period of at least one day. | 07-28-2011 |
20110184037 | METHODS FOR TREATING AN INTERVERTEBRAL DISC USING LOCAL ANALGESICS - Effective methods of treating back pain from an intervertebral disc are provided. The methods of treatment include administering an immediate release analgesic at or near the intervertebral disc; administering a bulking agent or sealing agent within the intervertebral disc; and administering a sustained release analgesic within the intervertebral disc, wherein the sustained release analgesic releases the analgesic over a period of at least one day. | 07-28-2011 |
20110189253 | BIOMATERIAL COMPOSITION AND METHOD - The disclosure is directed to a composition includes a macromer having a polymeric backbone comprising units with a 1,2-diol or 1,3-diol structure and at least two pendant chains bearing crosslinkable groups, an amphiphilic comonomer, and a crosslinking initiator, wherein the composition has a setting time of less than about 3 minutes. The disclosure is further directed to a kit and a method of making the above-mentioned composition. | 08-04-2011 |
20110313431 | SUTURE AND ANCHOR FOR PERIODONTAL PROCEDURES AND METHOD OF USING THE SAME - A suture system that includes at least one suture having an end portion, a loop portion configured to be disposed about a fixed point and an anchor configured to be connected to the end portion for anchoring the suture to tissue adjacent to the fixed point, wherein the loop portion of the suture is disposed about the fixed point so as to reduce a gap between the tissue and the fixed point. A kit including at least one suture system, a surgical tool for manipulating the suture and written instructions of use are disclosed. A method for using the suture system is also described. | 12-22-2011 |
20120009230 | MALLEABLE IMPLANTS CONTAINING DEMINERALIZED BONE MATRIX - Described are malleable medical compositions such as pastes or putties that include solids combined with a liquid carrier. The solids can include particulate collagen and particulate demineralized bone matrix. The liquid carrier includes an aqueous medium comprising one or more polysaccharides. Also described are methods for making and using such medical compositions. | 01-12-2012 |
20120021370 | BIODEGRADABLE STENTS AND METHODS FOR TREATING PERIODONTAL DISEASE - Biodegradable stents and methods for selectively guided tissue regeneration in treating a periodontal defect adjacent to a root of a tooth are provided. The biodegradable stents and methods comprise a coronal portion and a transverse portion or shelf, which reduce unwanted migration of gingival epithelium, gingival connective tissue, and soft tissue and enable the cementum and periodontal ligament cells to re-establish the periodontal ligament in a proper sequence resulting in a new periodontal attachment. | 01-26-2012 |
20120028219 | BIOADHESIVE FOR PERIODONTAL GINGIVAL AND/OR BONE TISSUES - The invention is directed to an adhesive strip, particularly an adhesive strip or bandage for use in periodontal treatments. The biocompatible adhesive strip comprises a flexible barrier with a biocompatible adhesive for use in an oral environment, wherein the adhesive is in a non-tacky state when dry and becomes adherent upon contact with liquids. | 02-02-2012 |
20120045735 | IMPLANT REPAIR SYSTEM AND METHOD - A dental implant system includes bone growth promoting material configured for disposal within a body cavity about an implant. A protective element is configured to overlay the bone growth promoting material. Methods of use are also disclosed. | 02-23-2012 |
20120045736 | ANCHORING IMPLANT - An implant includes a collar configured for disposal within tissue. The collar defines an axial bore. A shaft extends between a first end and a second end. The shaft is configured for disposal with the bore of the collar. A base defines an axial bore having an inner surface configured for engagement with the shaft such that the base is axially movable relative to the shaft. At least one arm extends between the collar and the base. The at least one arm is movable via axial movement of the base relative to the shaft between a first position and a second position such that the at least one arm is expanded in a configuration to engage tissue. Methods of use are also disclosed. | 02-23-2012 |
20120046663 | BONE SCORING DEVICE - A bone scoring device having a body, a scoring member configured to engage a bone surface and a first biasing member connected to and configured to rotate the scoring member is provided. The scoring member being axially movable between a first, non-rotatable position, such that the scoring member is engaged with the body and a second rotatable position such that the scoring member is released from engagement with the body and freely rotates. The scoring member having an abrasive surface to score the surface of the bone in which it is put in contact. A method for using the scoring device as well as a kit including the scoring device are also provided. | 02-23-2012 |
20120101404 | Methods for Detecting Osteolytic Conditions in the Body - Methods and systems for detecting a biological response indicative of osteolysis or preconditions in bone. | 04-26-2012 |
20120172885 | SURGICAL TACK DELIVERY SYSTEM, METHOD AND KIT - A system for delivering a surgical tack in tissue includes a driver, comprising: a shaft having a slot and a channel; and a handle slidably connected to said shaft and having a driving mechanism, said driving mechanism having a driving pin for providing a downward force through said shaft; and a tack cartridge having a plurality of tacks and adapted to be received in said slot and further adapted to feed said tacks between said driving mechanism and said channel. | 07-05-2012 |
20120196246 | REFLECTED GINGIVAL TISSUE RETRACTOR DEVICE FOR SURGICAL DENTAL PROCEDURES, KIT AND METHOD FOR USE THEREOF - A gingival tissue retractor for retracting gingival tissue away from tooth and bone during a surgical procedure having an alveolar bone grip having an open frame structure positionable over at least one tooth and along a predetermined segment of an alveolar bone and providing an inward resilient force about opposite sides of the alveolar bone for maintaining position of the gingival retractor; a first gingival reflector having a solid plate structure and attached to a lower section of one side of the alveolar bone grip for providing a primarily downward force to gingival tissue on one side of the alveolar bone; and a second gingival reflector having a solid plate structure and attached to a lower section of another side of the alveolar bone grip for providing a primarily downward force to gingival tissue on another side of the alveolar bone. | 08-02-2012 |
20120214127 | DENTAL IMPLANT SYSTEM WITH SEPARABLE DRIVE AND METHOD - A dental implant system includes an abutment including a first portion configured for disposal within an inner cavity of a dental implant and defining an outer surface configured for fixation with an inner surface of the dental implant. The abutment includes a second portion having a drive configured to separate from the abutment at a predetermined force. Methods of use are also disclosed. | 08-23-2012 |
20120231416 | PERIODONTAL SCALER AND PLANER COMBINED INSTRUMENT - Provided is a periodontal instrument adapted for use in debridement of a root surface of a tooth having an axially elongated shaft and a shank. The shank is disposed at an end of the shaft and has a body extending distally relative to the shaft. The body includes a plurality of blades adapted for use in debridement of a root surface. Each blade is configured for scaling and/or planning of a root surface and the shaft is dimensioned and configured to facilitate manual manipulation of the shank. Also provided is a removable tip periodontal instrument adapted for use in debridement of a root surface of a tooth and a kit including a device and a plurality of tips that may be color coded for easy reference by the clinician. | 09-13-2012 |
20130183634 | EXPANSION DEVICE FOR TREATMENT OF BLACK TRIANGLE DISEASE AND METHOD - An expansion device includes an inflatable balloon moveable from an unexpanded configuration to an expanded configuration configured to pass through soft tissue between two adjacent teeth of a patient when in the unexpanded configuration. The an expansion device also includes an inflation tube having one end connected to the inflatable balloon and another end serving as an entry port for an inflation fluid. The inflatable balloon has a triangular shape when in the expanded configuration. | 07-18-2013 |
20130189338 | BONE FIBERS HAVING EXTENDED LENGTH - Demineralized bone matrix fibers and demineralized bone compositions are provided. Implantable demineralized bone matrix compositions include elongated bone fibers having an average length from about 2 cm to about 6 cm and an aspect ratio from about 50:1 to about 1000:1. The demineralized bone matrix compositions also include a carrier in an amount sufficient to produce a cohesive formable mass. The elongated fibers can easily entangle to provide an improved demineralized bone matrix having increased osteoconductivity. | 07-25-2013 |
20130189344 | HUMAN LUBRICATION GEL - Human lubricating gels, methods and kits for delivering a therapeutic agent to a target tissue site beneath the skin of a patient utilizing human lubricating gel are provided, the human lubricating gel being capable of adhering to the target tissue site and comprising one or more biodegradable formulations containing an effective amount of the therapeutic agent. In various embodiments, the human lubricating gel is sprayable and hardens after contacting the target tissue site. | 07-25-2013 |
20130190891 | BONE DELIVERY SYSTEM - A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be formed of polymers for providing extended shelf life and/or increased moisture and radiation resistance, and may include a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance. In various embodiments, the covering may be formed of a biocompatible material and is suitable for a variety of procedure specific uses. | 07-25-2013 |
20140302129 | HUMAN LUBRICATION GEL - Human lubricating gels, methods and kits for delivering a therapeutic agent to a target tissue site beneath the skin of a patient utilizing human lubricating gel are provided, the human lubricating gel being capable of adhering to the target tissue site and comprising one or more biodegradable formulations containing an effective amount of the therapeutic agent. In various embodiments, the human lubricating gel is sprayable and hardens after contacting the target tissue site. | 10-09-2014 |