Krishnan, NC
K. Ranga Krishnan, Chapel Hill, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20090018115 | COMPOSITIONS OF AN ANTICONVULSANT AND AN ANTIPSYCHOTIC DRUG AND METHODS OF USING THE SAME FOR AFFECTING WEIGHT LOSS - Disclosed are compositions for affecting weight loss comprising a first compound and a second compound, where the first compound is a psychotherapeutic agent and the second compound is a anticonvulsant. Also disclosed are methods of affecting weight loss, increasing energy expenditure, increasing satiety in an individual, or suppressing the appetite of an individual, comprising identifying an individual in need thereof and treating that individual with a psychotherapeutic agent and an anticonvulsant. | 01-15-2009 |
| 20090148541 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF SEBORRHEA - Methods and compositions are provided for treating dermatological diseases, disorders, and pathologies, including seborrheic dermatitis, in a subject in need thereof. In some embodiments, methods are provided for the treatment of a dermatological disease, disorder, or pathology comprising, topically administering to a subject in need of dermatological treatment a composition comprising a therapeutically effective amount of bupropion, lithium or lithium salicylate, or combinations thereof. | 06-11-2009 |
K. Ranga R. Krishnan, Chapel Hill, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20080319036 | METHOD FOR TREATING OBESITY - The present invention relates, in general, to obesity, and, in particular, to a method of treating obesity and minimizing metabolic risk factors associated therewith using, for example, zonisamide or other weight-loss promoting anticonvulsant either alone or in combination with bupropion or other compound that enhances the activity of norepinephrine and/or dopamine via uptake inhibition or other mechanism. | 12-25-2008 |
| 20090076108 | METHOD FOR TREATING OBESITY - The present invention relates generally to methods of treating obesity and minimizing metabolic risk factors associated therewith using, for example, zonisamide or other weight loss-promoting anti-convulsant either alone or in combination with bupropion or metabolites thereof or other compound that enhances the activity of norepinephrine and/or dopamine via uptake inhibition or other mechanism. | 03-19-2009 |
| 20100179129 | COMPOSITIONS OF AN ANTICONVULSANT AND MIRTAZAPINE TO PREVENT WEIGHT GAIN - Disclosed are pharmaceutical compositions comprising mirtazapine and an anticonvulsant drug. Also disclosed are methods of preventing weight gain associated with the administration of mirtazapine comprising identifying a patient to whom mirtazapine is to be administered and administering to said patient a pharmaceutical composition comprising mirtazapine and an anticonvulsant drug. Further disclosed are methods of increasing the efficacy of mirtazapine comprising identifying a patient to whom mirtazapine is to be administered and administering to said patient a pharmaceutical composition comprising mirtazapine and an anticonvulsant drug. | 07-15-2010 |
| 20110098289 | METHOD FOR TREATING OBESITY - The present invention relates generally to methods of treating obesity and minimizing metabolic risk factors associated therewith using, for example, zonisamide or other weight loss-promoting anti-convulsant either alone or in combination with bupropion or metabolites thereof or other compound that enhances the activity of norepinephrine and/or dopamine via uptake inhibition or other mechanism. | 04-28-2011 |
| 20140364468 | METHOD FOR TREATING OBESITY - The present invention relates generally to methods of treating obesity and minimizing metabolic risk factors associated therewith using, for example, zonisamide or other weight loss-promoting anti-convulsant either alone or in combination with bupropion or metabolites thereof or other compound that enhances the activity of norepinephrine and/or dopamine via uptake inhibition or other mechanism. | 12-11-2014 |
K. Ranga Rama Krishnan, Chapel Hill, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20090197242 | Lipidomic Approaches to Determining Drug Response Phenotypes in Cardiovascular Disease - The present invention concerns the application of lipidomics to statin treatment for disorders such as cardiovascular disorders. Hence, the invention provides, among other things, a method of correlating a lipid profile with a positive or negative response to a statin treatment regimen by obtaining a lipid profile of a sample from a mammalian subject following commencement of the treatment regimen; and correlating the lipid profile in the sample with a positive or negative response to the treatment regimen. The invention further provides a method of correlating a lipid profile with a positive or negative response to a statin treatment regimen by obtaining a lipid profile of a sample from a mammalian subject before commencement of the treatment regimen; and correlating the lipid profile in the sample with a positive or negative response to the treatment regimen. | 08-06-2009 |
| 20090305323 | LIPIDOMICS APPROACHES FOR CENTRAL NERVOUS SYSTEM DISORDERS - The present invention has utilized the power of lipidomics to profile lipid metabolites and to characterize changes in lipid metabolism as they relate to CNS disorders. Lipidomic signatures can guide the development of diagnostic, prognostic and surrogate markers for CNS disorders; identification of new targets for drug design based on highlighted perturbed pathways; stratify patients with CNS disorders as to which pathways are impaired, and facilitate the determination of which patients with CNS disorders are candidates for a particular therapy, i.e. provide the tools for a personalized approach to therapy; identify which patients are responding or are developing side effects to a treatment; design of modified antipsychotics that have less metabolic side effects and enhanced activity; overcome the lag phase in response to some treatments; and find better combination therapies for CNS disorders that target the pathways that are impaired (e.g., impairments in lipid and/or carbohydrate metabolism). | 12-10-2009 |
Ram Krishnan, Chapel Hill, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20140072059 | POWER LINE COMMUNICATION NETWORK AND DISCOVERY PROCESS - An apparatus for a power line communication network includes a power line transmitter/receiver, a processor coupled to the power line transmitter/receiver, and memory accessible to the processor. The processor is configured to store a routing table in the memory for routing packets in an upward direction towards a data concentrator (DC). However, no routing table is provided for routing packets in a downward direction away from the DC. Instead of using a routing table to route packets in the downward direction, the processor is configured to employ source routing in the downward direction. | 03-13-2014 |
| 20140301409 | SYSTEM AND METHOD FOR AVOIDING HIDDEN NODE COLLISIONS IN A COMMUNICATION NETWORK - Method and apparatus for avoiding hidden node collisions in a communication network. A network communication device includes a packet transmitter. The packet transmitter is configured to subdivide a packet to be transmitted via a communication network into a plurality of segments based on the packet exceeding a predetermined maximum size, and to sequentially transmit the segments via the communication network. The packet transmitter is also configured to construct an acknowledgement packet responsive to reception of each segment of a packet received via the communication network. The acknowledgement packet includes a field indicating whether an additional segment of the packet is to be transmitted via the communication network. The packet transmitter is further configured to transmit the acknowledgement packet via the communication network. | 10-09-2014 |
Ram Krishnan, Carrboro, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20130194965 | KEEP ALIVE MESSAGE OVERHEAD REDUCTION FOR COMMUNICATION NETWORKS - A method of communications in a network having plurality of nodes including a base node (BN) and a plurality of levels (i) each including at least one service node (SN). The number (Ni(t)) of SNs registered in each of a plurality of i are determined. The current Keep Alive timer out (KA_TO) value for a KA timer at the BN is dynamically adjusted to an updated KA_TO value based on Ni(t) and i. Dynamically adjusting KA_TO values reduces the KA message overhead the network compared to known KA_TO value implementations. | 08-01-2013 |
Ranga Krishnan, Chapel Hill, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20080280983 | METHODS OF TREATING RETT SYNDROME - The present embodiments relate to methods for the treatment of Rett Syndrome. More specifically, the present embodiments relate to pivagabine for use in the treatment of Rett Syndrome. Some embodiments relate to treatment of a patient with Rett Syndrome. Other embodiments relate to treatment of the indications of Rett Syndrome. | 11-13-2008 |
| 20090258860 | XANTHINE DERIVATIVES FOR THE TREATMENT OF VASCULAR DEPRESSION - Methods and compositions are provided for treating vascular depression. The methods involve administering to a subject in need thereof a xanthine derivative in a therapeutically effective amount to treat vascular depression, particularly the xanthine derivatives pentoxifylline or propentofylline. The methods may further include administration of an additional therapeutic agent in combination with the xanthine derivative selected from the group consisting of a selective serotonin reuptake inhibitor (SSRI), a serotonin-norepinephrine reuptake inhibitor (SNRI), and a drug used in the treatment of cerebrovascular disease. Compositions of the invention include pharmaceutical compositions and kits for treating vascular depression in a subject in need thereof that include therapeutically effective amounts of a xanthine derivative and an additional therapeutic agent selected from the group consisting of an SSRI, an SNRI, and a drug used in the treatment of cerebrovascular disease. | 10-15-2009 |
Ranga R. Krishnan, Chapel Hill, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20090192166 | METHOD FOR AUGMENTING THE EFFECTS OF SEROTONIN REUPTAKE INHIBITORS - A method of treating a subject for a serotonergic neurotransmission dysregulation disorder, comprises administering the subject a serotonin enhancer (e.g., a serotonin reuptake inhibitor) in an amount effective to treat the disorder; and concurrently administering the subject 5-hydroxytryptophan in an amount effective to enhance the activity of the serotonin enhancer, (e.g., serotonin reuptake inhibitor). In preferred embodiments the disorder is depression, anxiety, or substance abuse. | 07-30-2009 |
| 20130338192 | METHOD FOR AUGMENTING THE EFFECTS OF SEROTONIN REUPTAKE INHIBITORS - A method of treating a subject for a serotonergic neurotransmission dysregulation disorder, comprises administering the subject a serotonin enhancer (e.g., a serotonin reuptake inhibitor) in an amount effective to treat the disorder; and concurrently administering the subject 5-hydroxytryptophan in an amount effective to enhance the activity of the serotonin enhancer, (e.g., serotonin reuptake inhibitor). In preferred embodiments the disorder is depression, anxiety, or substance abuse. | 12-19-2013 |
Srinivas Krishnan, Carrboro, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20100161711 | MEASURING CLIENT INTERACTIVE PERFORMANCE USING A DISPLAY CHANNEL - Methods, systems, and computer programs for measuring performance of virtual desktop services offered by a server computer are presented. The method includes receiving from a client computer an action request to be executed at the server computer, where the server computer is configured to generate display views for the requesting client. The method further embeds, at the server computer, a first encoded pixel into a first image frame that is communicated to the client computer when acknowledging receipt of the action request. Further, the method embeds a second encoded pixel into a second image frame that is communicated to the client computer after completion of the action associated with the action request. Action performance time is stored in memory, where the action performance time is the time between arrivals of the first and second image frames at the client computer. The stored timing information is used to generate statistical performance data. | 06-24-2010 |
| 20100162338 | MEASURING REMOTE VIDEO PLAYBACK PERFORMANCE WITH EMBEDDED ENCODED PIXELS - Methods, systems, and computer programs for measuring performance of remote video delivery are presented. The method embeds at a server computer a marker in selected frames of a video stream. The marker includes a preconfigured sequence of pixels and is followed by a frame number encoded in the pixel data. The method then finds a first marker at a client computer to determine the location of the markers in a display. Once the location of the markers is determined, markers in following frames are detected with their corresponding frame numbers. The method stores the arrival times and frame numbers for each detected marker. The stored arrival times and frame numbers can be used for statistical performance analysis of remote video delivery. | 06-24-2010 |
| 20110047211 | Measuring Client Interactive Performance Using a Display Channel - Methods, systems, and computer programs for measuring performance of virtual desktop services offered by a server computer are presented. The method includes receiving an action request at the server computer, where the server computer is configured to generate display views for the requesting client. The method further embeds, at the server computer, a first encoded area into a first image frame that is communicated to a client computer when acknowledging receipt of the action request. After the action associated with the action request is completed, the method embeds a second encoded area into a second image frame that is communicated to the client computer. Action performance time is stored in memory, where the action performance time is based on the time difference between arrivals of the first and second image frames at the client computer. The stored timing information is used to generate statistical performance data. | 02-24-2011 |
| 20120127995 | BACKBONE NETWORK WITH POLICY DRIVEN ROUTING - A source device obtains a data packet that includes both a destination address and a payload. The source device selects an exit point address of multiple exit point addresses corresponding to the destination address based on one or more policies. The source device encapsulates the data packet with a header that includes the selected exit point address, and the encapsulated data packet is provided to the backbone network. The encapsulated data packet is routed through the backbone network based on the exit point address, and an edge router of the backbone network identifies an interface of the edge router that corresponds to the exit point address. The header is removed from the encapsulated data packet, and the data packet is added to a buffer of the interface for routing to one or more other devices outside of the backbone network. | 05-24-2012 |
| 20140157407 | METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR EFFICIENT COMPUTER FORENSIC ANALYSIS AND DATA ACCESS CONTROL - According to one aspect, the subject matter described herein includes a method for efficient computer forensic analysis and data access control. The method includes steps occurring from within a virtualization layer separate from a guest operating system. The steps include monitoring disk accesses by the guest operating system to a region of interest on a disk from which data is copied into memory. The steps also include tracking subsequent accesses to the memory resident data where the memory resident data is copied from its initial location to other memory locations or over a network. The steps further include linking operations made by the guest operating system associated with the disk accesses with operations made by the guest operating system associated with the memory accessed. | 06-05-2014 |
| 20140181976 | METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR DETECTING INJECTED MACHINE CODE - According to one aspect, the subject matter described herein includes a method for detecting injected machine code. The method includes extracting data content from a buffer. The method also includes providing an operating system kernel configured to detect injected machine code. The method further includes executing, using the operating system kernel, the data content on a physical processor. The method further includes monitoring, using the operating system kernel, the execution of the data content to determine whether the data content contains injected machine code indicative of a code injection attack. | 06-26-2014 |
Venkataram Krishnan, Cary, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20080207774 | ANIONIC LATEX AS A CARRIER FOR ACTIVE INGREDIENTS AND METHODS FOR MAKING AND USING THE SAME - This invention relates to the field of polymeric materials that can be used in combination with a wide variety of substrates, such as personal care products, textiles, metal, cellulosic materials, plastics, and the like, and to the field of active agents including, for example, antimicrobial, antibacterial and antifungal materials. This invention further relates to latex polymer coatings that comprise at least one active component as well as methods for making and using such latex compositions. | 08-28-2008 |
| 20080226584 | ANTIMICROBIAL AND ANTISTATIC POLYMERS AND METHODS OF USING SUCH POLYMERS ON VARIOUS SUBSTRATES - The present invention relates to a substrate having one or more antimicrobial or antistatic properties. Such properties are imparted by applying a coating or film formed from a cationically-charged polymer composition. The polymer composition includes a noncationic ethylenically unsaturated monomer and an ethylenically unsaturated monomer capable of providing a cationic charge to the polymer composition. Optionally, the polymer composition includes a steric stabilization component incorporated into the cationically-charged polymer composition. The present invention also relates to a personal care product and polymeric material comprising a base polymer blended with the above cationically-charged polymer composition. | 09-18-2008 |
| 20080233062 | CATIONIC LATEX AS A CARRIER FOR ACTIVE INGREDIENTS AND METHODS FOR MAKING AND USING THE SAME - This invention relates to the field of polymeric materials that can be used in combination with a wide variety of substrates, such as textiles, metal, cellulosic materials, plastics, and the like, and to the field of active agents including, for example, antimicrobial, antibacterial, and antifungal materials. This invention further relates to latex polymer coatings that comprise at least one active component as well as methods for making and using such latex compositions. | 09-25-2008 |
| 20120238719 | ASSOCIATIVE ACID SWELLABLE THICKENERS - Provided is a thickener composition comprising the polymerization product of an aromatic monomer, an amine functional monomer, and a hydrophobic, associative monomer. The thickener composition is capable of thickening various formulations at a pH of 6.0 or less. Also provided are personal care, household, and industrial formulations that include the thickener compositions. | 09-20-2012 |