Witzel, US
Andreas Witzel, New York, NY US
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20120290278 | PROCESS, COMPUTER-ACCESSIBLE MEDIUM AND SYSTEM FOR OBTAINING DIAGNOSIS, PROGNOSIS, RISK EVALUATION, THERAPEUTIC AND/OR PREVENTIVE CONTROL BASED ON CANCER HALLMARK AUTOMATA - The present disclosure relates to exemplary embodiments of method, computer-accessible medium, system and software arrangements for, e.g., Cancer Hallmark Automata, a formalism to model the progression of cancers through discrete phenotypes (so-called hallmarks). The precise computational model described herein includes the automatic verification of progression models (e.g., consistency, causal connections, etc.), classification of unreachable or unstable states (e.g., “anti-hallmarks”) and computer-generated (individualized or universal) therapy plans. Exemplary embodiments abstractly model transition timings between hallmarks as well as the effects of drugs and clinical tests, and thus allows formalization of temporal statements about the progression as well as notions of timed therapies. Certain exemplary models discussed herein can be based on hybrid automata (e.g., with multiple clocks), for which relevant verification and planning algorithms exist. | 11-15-2012 |
20130317755 | Methods, computer-accessible medium, and systems for score-driven whole-genome shotgun sequence assembly - Exemplary systems, methods and computer-accessible mediums for assembling at least one haplotype or genotype sequence of at least one genome can be provided, which can include, obtaining a plurality of randomly located sequence reads, incrementally generating overlap relations between the randomly located sequence reads using a plurality of overlapper procedures, and generating a layout of some of the randomly located short sequence reads based on a function in combination with constraints based on information associated with the one genome while substantially satisfying the constraints. The score-function can be derived from overlap relations between the randomly located short sequence reads. A search can be performed together with score- and constraint-dependent pruning to determine the layout substantially satisfying the constraints. A part of the genome wide haplotype sequence or the genotype sequence of the genome can be generated based on the overlap relations and the randomly located sequence reads. | 11-28-2013 |
Gustav Witzel, Warminster, PA US
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20090232518 | OPTICAL TRANSMITTER WITH ADAPTIVELY CONTROLLED OPTICALLY LINEARIZED MODULATOR - An optical transmitter for generating a modulated optical signal to be transmitted over fiber optical link. The transmitter includes: an optical source for producing an optical signal; an optically linearized modulator (OLM) as external modulator for modulating the optical signal produced by the optical source with an information carrying signal. The external modulator includes a first input port for receiving a first DC bias signal, and a second input port for receiving a second DC bias signal. The optical transmitter further includes a pilot tone generator for generating a first pilot signal to be applied to the first input port and a second pilot signal to be applied to the second input port. The first and second pilot signals are capable of producing distortion products in the modulated optical signal. A differential modulation signal is imposed onto either the first pilot signal or the second pilot signal so as to generate a first control signal that alternately adjusts the first DC bias signal and the second DC bias signal in order to minimize the distortion products. The optical transmitter may include a digital based control system that is adapted to reduce composite even and odd order distortions in the OLM. | 09-17-2009 |
20120243874 | Radio Frequency Optical Communication System - An optical communication system for generating and transmitting a modulated optical signal in which light emitted by a light source is modulated by an optical modulator in accordance with an input electrical signal. A bias signal generator applies a bias electrical signal to bias the optical modulator at a bias angle away from quadrature. The bias signal generator monitors the input electrical signal and adjusts the applied bias electrical signal in dependence on the input electrical signal. The system further includes a receiver which may include an equalizer coupled to the photodetector of the receiver. | 09-27-2012 |
Jeffrey G. Witzel, St. Augustine, FL US
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20090108028 | APPARATUSES TO DELIVER SMALL AMOUNTS OF FLUIDS AND METHODS OF USING THE SAME - This invention relates to devices and methods to deliver small amounts of fluid in a production environment. | 04-30-2009 |
John George Witzel, Alexandria, VA US
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20110037452 | DETECTION OF GROUND-LAID WIRE USING ULTRAVIOLET C-BAND RADIATION - A system for tracing wire includes an electrical exciter adapted to apply a voltage to a ground-laid wire to generate a corona at an outer surface of the ground laid wire, at least a portion of the corona including ultraviolet c-band radiation, and an ultraviolet c-band detector to detect the ultraviolet c-band radiation to trace at least a portion of the path of the ground-laid wire. | 02-17-2011 |
20110057804 | SEARCH AND RESCUE USING ULTRAVIOLET RADIATION - A system for search and rescue includes a rescue beacon including a radiation source to emit radiation, at least a portion of which includes ultraviolet c-band radiation, and an ultraviolet c-band detector to detect the ultraviolet c-band radiation to enable locating of the rescue beacon. | 03-10-2011 |
20110068938 | SEARCH AND RESCUE USING ULTRAVIOLET RADIATION - A system includes an ultraviolet c-band radiation detector to enable detection of radiation during search and rescue operations, at least a portion of the radiation including ultraviolet c-band radiation, and a stimulus generator configured to generate a stimulus in response to detected ultraviolet c-band radiation. Further embodiments may include multiple synchronized ultraviolet c-band detectors to enhance system sensitivity and facilitate detection of relatively weak radiation sources, relatively distant sources, and/or radiation scattered about an environment. | 03-24-2011 |
Julie Dickson Witzel, Arlington Heights, IL US
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20090017534 | SLO2 AND SLO4, NOVEL POTASSIUM CHANNEL PROTEINS FROM HUMAN BRAIN - The invention provides isolated nucleic acid and amino acid sequences of Slo2 and Slo4, members of the Slo family of potassium channel proteins, also known as “maxi” or BK potassium channel proteins. Also provided herein are antibodies to Slo2 and Slo 4, methods of detecting Slo2 and Slo 4, methods of screening for potassium channel activators and inhibitors using biologically active Slo2 and Slo 4, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising Slo2 and Slo 4. | 01-15-2009 |
Julie Dickson Witzel, Raleigh, NC US
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20100267930 | SLO2 and SLO4, Novel Potassium Channel Proteins from Human Brain - The invention provides isolated nucleic acid and amino acid sequences of Slo2 and Slo4, members of the Slo family of potassium channel proteins, also known as “maxi” or BK potassium channel proteins. Also provided herein are antibodies to Slo2 and Slo 4, methods of detecting Slo2 and Slo 4, methods of screening for potassium channel activators and inhibitors using biologically active Slo2 and Slo 4, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising Slo2 and Slo 4. | 10-21-2010 |
Thomas Witzel, Cambridge, MA US
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20080281183 | STIMULUS INDUCED ROTARY SATURATION FOR MAGNETIC RESONANCE FUNCTIONAL IMAGING - Spin-lock T | 11-13-2008 |
20090123384 | METHOD FOR MAGNETIC RESONANCE IMAGING USING STIMULUS INDUCED ROTARY SATURATION WITH A CONTRAST AGENT - A method and system for producing an image of a subject with a magnetic resonance imaging (MRI) system, in which the presence of a contrast agent is detected using a spin-lock pulse sequence, is described. More specifically, a contrast agent that induces saturation of magnetic resonance signals responsive to a spin-lock condition is administered to a subject. A spin-lock condition is subsequently established to saturate spins in proximity to the contrast agent. Image data is then acquired with an imaging pulse sequence and images indicative of the presence of the contrast agent are reconstructed. | 05-14-2009 |
20100090693 | METHOD AND APPARATUS FOR CONTROLLING T1 RECOVERY PROCESS IN MAGNETIC RESONANCE MEASUREMENTS - Radiation damping (RD) is employed to hasten the recovery of longitudinal magnetization after RF excitation and signal readout in a magnetic resonance measurement cycle. A switch driven by the pulse sequence that performs the measurement cycle energizes a feedback RF coil driven by an amplified and phase shifted portion of the received MR signal. The recovery of longitudinal magnetization is thus under direct control of the MR system and enables the reduction of the otherwise inefficient waiting times that are required for natural T1 recovery of the excited spin magnetization. This enables shortened acquisition times, improved sensitivity, better spatial and temporal resolution, and reduction of motion artifacts that result from long acquisition times. | 04-15-2010 |
Thomas Witzel, Laguna Niguel, CA US
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20140163652 | METHOD FOR TREATING AND REPAIRING MITRAL VALVE ANNULUS - A catheter system for repairing an annular organ structure of a patient, comprising: intimately contacting the annular organ structure by a tissue-contactor member having energy-delivering elements; and delivering tissue-shrinkable energy at the annular organ structure through the elements, wherein the tissue-shrinkable energy is applied at a distance wirelessly from the elements sufficient to shrink and tighten the organ structure. Tissue-shrinkable energy is infrared energy, ultrasound energy, focused ultrasound energy, ultrasound energy, radiofrequency energy, microwave energy, electromagnetic energy, laser energy, or a combination thereof. | 06-12-2014 |
Thomas Witzel, Boston, MA US
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20150323634 | Methods, Systems and Apparatuses for Rapid Segmented, Accelerated, and Simultaneous Multi-Slice Echo Planar Imaging - A method for accelerated segmented magnetic resonance (MR) image data acquisition includes using a plurality of RF pulses to excite one or more slices of an anatomical area of interest according to a predetermined slice acceleration factor. Next, a collapsed image comprising the slices is acquired using a consecutive segment acquisition process. Then, a parallel image reconstruction method is applied to the collapsed image to separate the collapsed image into a plurality of slice images. | 11-12-2015 |