Patent application number | Description | Published |
20090176233 | Screening assays for polymerase enhancement - Methods of screening for and selecting for improved polymerases suitable for single molecule sequencing are provided. | 07-09-2009 |
20100093555 | Enzymes resistant to photodamage - Provided are compositions comprising modified DNA polymerases that exhibit improved photostability compared to the parental polymerases from which they were derived. Provided are methods for generating enzymes, such as DNA polymerases, with the aforementioned phenotype. Provided are methods of using polymerases with increased resistance to photodamage to make a DNA or to sequence a DNA template. | 04-15-2010 |
20100112645 | Generation of modified polymerases for improved accuracy in single molecule sequencing - Provided are compositions comprising modified recombinant polymerases that exhibit branching fractions that are less than the branching fractions of the polymerases from which they were derived, or branching fractions that are less than about 25% for a phosphate-labeled nucleotide analog. Also provided are compositions comprising modified recombinant polymerases that exhibit closed polymerase/DNA complexes with increased stability relative to the parental polymerases. Also provided are compositions comprising modified recombinant polymerases that exhibit decreased rate constants relative to the parental polymerases. Provided are methods for generating polymerases with the aforementioned phenotypes. Provided are methods of using such polymerases to make a DNA or to sequence a DNA template. | 05-06-2010 |
20110059505 | Polymerases for nucleotide analogue incorporation - Compositions that include polymerases with features for improving entry of nucleotide analogues into active site regions and for coordinating with the nucleotide analogues in the active site region are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA replication and amplification as well as kinetic models of polymerase activity and computer-implemented methods of using the models are also provided. | 03-10-2011 |
20110160077 | SEQUENCING METHODS USING ENZYME CONFORMATION - Systems and methods are provided for single-molecule sequencing of template nucleic acids in which the signal from a label attached to a polymerase enzyme is used to monitor conformational changes in the polymerase which occur while labeled nucleotides or nucleotide analogs are added to a growing nucleic acid chain which is complementary to the template nucleic acid. The signal indicative of the conformational state of the enzyme is used to determine with higher confidence when true nucleotide or nucleotide analog incorporation events occur, allowing for the improved quality of base calls and sequence determination. | 06-30-2011 |
20110189659 | Generation of modified polymerases for improved accuracy in single molecule sequencing - Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions and/or heterologous or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing. Such properties can include reduced reaction rates at one or more steps of the polymerase kinetic cycle, increased closed polymerase/DNA complex stability, enhanced metal ion coordination, reduced exonuclease activity, decreased branching fractions, and the like. Polymerases that exhibit branching fractions that are less than the branching fractions of the polymerases from which they were derived, or branching fractions that are less than about 25% for a phosphate-labeled nucleotide analog, are also provided. Also provided are nucleic acids which encode the polymerases with the aforementioned phenotypes, as well as methods of using such polymerases to make a DNA or to sequence a DNA template. | 08-04-2011 |
20120034602 | Recombinant Polymerases For Improved Single Molecule Sequencing - Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing. Such properties can include enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, increased yield, increased thermostability, increased accuracy, increased speed, increased readlength, and the like. Also provided are nucleic acids which encode the polymerases with the aforementioned phenotypes, as well as methods of using such polymerases to make a DNA or to sequence a DNA template. | 02-09-2012 |
20150184239 | Polymerases for Nucleotide Analogue Incorporation - Compositions that include polymerases with features for improving entry of nucleotide analogues into active site regions and for coordinating with the nucleotide analogues in the active site region are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA replication and amplification as well as kinetic models of polymerase activity and computer-implemented methods of using the models are also provided. | 07-02-2015 |
Patent application number | Description | Published |
20090028161 | NETWORK TRAFFIC MANAGEMENT - One aspect of the specification is the use of a virtual entity to represent the bandwidth bottleneck point in a network. Areas of the network where bandwidth does not need to be managed can be modeled as zones. This model enables more flexibility as the virtual bottleneck point can represent a collection of components (e.g. routers), or a portion of a real component (e.g. a router could be represented by multiple virtual bottleneck points with different purposes.) This model can also allow a user to decide which points in their network should be managed, independent of the underlying data network infrastructure. These virtual entities can be placed between areas of the network, and configured with specific policies. Bandwidth usage across these virtual entities can be tracked and compared to the configured bandwidth limit available to the application at each bottleneck point. When the bandwidth available at the bottleneck point is fully utilized, additional calls can be blocked or rerouted. Policies can be applied to permit certain calls to proceed despite the fact that bandwidth is fully utilized, or to block certain calls when bandwidth usage is approaching the maximum level. Bandwidth management can be distributed or centralized with information shared throughout a distributed network. | 01-29-2009 |
20090028163 | DISTRIBUTED NETWORK MANAGEMENT - This specification can provide resource allocation in peer-to-peer networks. This specification describes techniques whereby individual resources can in certain circumstances share their local views to create a network-wide view. The use of a performance manager facilitates this sharing. The sharing of fault information both access multiple devices and for a single device across restarts is also provided. A network-based aggregator for performance and fault analysis is also provided so that complex analysis algorithms can be provided centrally to assist network performance management. | 01-29-2009 |
20090177782 | System and method for associating communication devices - A system and method of associating at least two communication devices is provided. First information identifying a first communication device and second information identifying a second communication device is received via a link layer protocol over a data network. It is determined if the first communication device and the second communication device are co-located based on first link layer data associated with the first communication device and second link layer data associated with the second communication device. An association is triggered between the first information and the second information if the first communication device and the second communication device are determined to be co-located. | 07-09-2009 |
20100189094 | System and method for transition of association between communication devices - A system and method of providing an assignable registration between a device and a user for IP telephony, wireless telephony and other forms of collaborative systems is provided wherein loss of association is detected and a policy language is used to capture and execute user preferences in the event of such loss. A method and system are also provided for utilizing coupling between a thin client and a telephone to provide for device association. | 07-29-2010 |
20100265938 | Enhanced system operation by virtualization - A system and method for enhanced operation of internet protocol (IP) telephony is disclosed. The system comprises a call server. The call server includes a shared resources module, a virtual machine environment in communication with the shared resources module the virtual machine having a plurality of virtual machines. A plurality of telecommunication function applications operate on separate instances. Each instance is operable to be connected to a customer through a network connection in communication with at least one of the plurality of virtual machines. | 10-21-2010 |
Patent application number | Description | Published |
20080300909 | Exclusivity in internet marketing campaigns system and method - A marketing campaign collects data for page counts, sessions, orders, and revenue. Four kinds of campaigns are addressed: direct, deferred, site link tracking, and deferred site link tracking. A particular page visit in an end-user session “qualifies” for a campaign if it satisfies the configured conditions for the campaign; that is, if the target universal resource locator (URL) of the page is the landing page of the campaign, the referrer URL is the referrer page of the campaign, or the page tag contains the configured string for the campaign. The data is processed through a set of heuristics identified by marketing experts as the most likely paths to a sale, and exclusivity is assigned to the type of campaign with the highest priority. | 12-04-2008 |
20090006478 | Days and Visits to Transaction Metrics System and Method - A system and method for tracking and reporting days and visits to an online transaction is described. A web analytic system receives web site visit tracking information from a client computer as a user navigates the web site. The system updates a reporting database with visit information. The system may receive data in the form of a report message sent from a site, where the data has been calculated to give the metric or where the message provides the raw data required to derive the metric. The system generates a variety of reports showing time between visits and transactions, such as time between visits, orders, downloads, form completion or other such transactions. | 01-01-2009 |
Patent application number | Description | Published |
20090012627 | Double-structured tissue implant and a method for preparation and use thereof - A double-structured tissue implant and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A stand alone secondary scaffold implant or unit. A process for preparation of the double-structured implant or the stand alone secondary scaffold comprising lyophilization and dehydrothermal treatment. | 01-08-2009 |
20090012628 | Method for use of a double-structured tissue implant for treatment of tissue defects - A method for use of a double-structured tissue implant or a secondary scaffold stand alone implant for treatment of tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A stand alone secondary scaffold implant or unit. | 01-08-2009 |
20090054984 | Method For Use Of A Double-Structured Tissue Implant For Treatment Of Tissue Defects - A method for use of a double-structured tissue implant or a secondary scaffold stand alone implant for treatment of tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A method of use of a stand alone secondary scaffold implant or unit for treatment of tissue defects. | 02-26-2009 |
20090069903 | Method For Improvement Of Differentiation Of Mesenchymal Stem Cells Using A Double-Structured Tissue Implant - A double-structured tissue implant (DSTI) and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant for differentiation, growth and transformation of cells, stem cells, mesenchymal stem cells and bone marrow stem cells. DSTI comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. | 03-12-2009 |
20130259910 | METHOD FOR USE OF A DOUBLE-STRUCTURED TISSUE IMPLANT FOR TREATMENT OF TISSUE DEFECTS - A method for use of a double-structured tissue implant or a secondary scaffold stand alone implant for treatment of tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A method of use of a stand alone secondary scaffold implant or unit for treatment of tissue defects. | 10-03-2013 |
20140193468 | METHODS FOR PREPARATION OF NEO-CARTILAGE CONSTRUCTS - The invention generally relates to systems (i.e. constructs) for repairing cartilage and methods for preparing the same that introduce a bioactive agent into a culture medium, suspension, scaffold, solution incorporated into the pores of the scaffold, or combinations thereof. The introduction of a bioactive agent promotes production of neo-cartilage (i.e. immature hyaline cartilage) in the system, both ex-vivo and in-vivo. | 07-10-2014 |
20140302227 | Methods of coating a construct with methylated collagen - A double-structured tissue implant and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A stand alone secondary scaffold implant or unit. A process for preparation of the double-structured implant or the stand alone secondary scaffold comprising lyophilization and dehydrothermal treatment. | 10-09-2014 |
20150359623 | METHOD FOR USE OF A DOUBLE-STRUCTURED TISSUE IMPLANT FOR TREATMENT OF TISSUE DEFECTS - A method for use of a double-structured tissue implant or a secondary scaffold stand alone implant for treatment of tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A method of use of a stand alone secondary scaffold implant or unit for treatment of tissue defects. | 12-17-2015 |
Patent application number | Description | Published |
20100226917 | METHODS FOR THE TREATMENT OF HEMATOLOGIC MALIGNANCIES - The present invention discloses, in part, therapies for treating hematologic malignancies, including B cell lymphomas and leukemias or B cell related tumors comprising the administration of a CHK1 inhibitor in combination with a B cell depleting antibody. The present invention further includes treating hematologic malignancies, including B cell lymphomas and leukemias, or B cell related tumors, which are resistant to cancer treatment comprising the administration of a CHK1 inhibitor. | 09-09-2010 |
20100240645 | COMBINATION OF CHECKPONIT KINASE (CHK) AND TELANGIECTASIA MUTATED (ATM) INHIBITORS FOR THE TREATMENT OF CANCER - A combination, comprising a checkpoint kinase (CHK) inhibitor, or a pharmaceutically acceptable salt thereof, and an ataxia telangiectasia mutated (ATM) inhibitor, or a pharmaceutically acceptable salt thereof is described. | 09-23-2010 |
20100249112 | COMBINATION OF CHK AND PARP INHIBITORS FOR THE TREATMENT OF CANCERS - A combination, comprising a checkpoint kinase (CHK) inhibitor, or a pharmaceutically acceptable salt thereof, and a poly (ADP-ribose)polymerase (PARP) inhibitor, or a pharmaceutically acceptable salt thereof is described. | 09-30-2010 |