Pogue, US
Brian W. Pogue, Hanover, NH US
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20110275932 | Method And Apparatus For Depth-Resolved Fluorescence, Chromophore, and Oximetry Imaging For Lesion Identification During Surgery - A tomographic fluorescent imaging device for imaging fluorophores in biological tissues has a scanned laser for scanning the tissue and a camera for receiving light from the biological tissue at an angle to the beam at a second wavelength ten or more nanometers greater in wavelength than the wavelength of the laser. Use of both intrinsic and extrinsic fluorophores is described. Images are obtained at each of several positions of the beam. An image processing system receives the series of images, models a path of the beam through the tissue, and determines depth of fluorophore in tissue from intersections of the modeled path of the beam and the path of the received light. The laser is of 600 nm or longer wavelength, to provide penetration of tissue. The imaging device is used during surgery to visualize lesions of various types to ensure complete removal of malignant tumors. An alternative embodiment uses differences in intensity of fluorescent radiation from tissue as observed at different wavelengths to determine depth of fluorophore in tissue. An embodiment operates at multiple wavelengths to construct tomographic images of chromophores, such as hemoglobin, and is capable of dynamic imaging. | 11-10-2011 |
20150374308 | Method And Apparatus For Medical Imaging Using Differencing Of Multiple Fluorophores - A method of generating corrected fluorescence data of concentrations of a targeted fluorophore in tissue of a subject includes administering first and second fluorescent contrast agents to the subject, the first contrast agent targeted to tissue of interest, the second agent untargeted. The tissue is illuminated with light of a first stimulus wavelength and first data is acquired at an appropriate emissions wavelength; the tissue is illuminated at a second stimulus wavelength and second data is acquired at a second emissions wavelength associated with the second agent, the first and second emissions wavelength differ. Difference data is generated by subtracting the second data from the first data. A system provides for stimulus and capture at multiple wavelengths, with image storage memory and subtraction code, to perform the method. Corrected data may form an fluorescence image, or is used to generate fluorescence tomographic images. | 12-31-2015 |
Brian William Pogue, Hanover, NH US
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20090247847 | SYSTEMS AND METHODS FOR TOMOGRAPHIC IMAGE RECONSTRUCTION - Optical tomography systems that provide light of multiple distinct wavelengths from a plurality of sources are described. The systems direct light into mammalian tissue, and light from the mammalian tissue is collected at a plurality of reception points. Collected light from each reception point is separated according to its wavelength, and received by a photodetector to produce path attenuation signals representing attenuation along paths between the source locations and the reception points. An image construction system generates a tomographic image of the mammalian tissue from the path attenuation signals. One embodiment of an optical imaging system includes an optical coherence tomography-near infrared probe. The systems and methods may utilize a spectral derivative approach that provides insensitivity to the boundary and boundary artifacts in the signal, thereby improving the quality of the reconstructed images. | 10-01-2009 |
20100265493 | Pulsed Lasers in Frequency Domain Diffuse Optical Tomography and Spectroscopy - A diffuse optical tomography system incorporating a mode-locked, tunable laser produces pulsed light that may be used to interrogate tissue with high spatial and spectral resolution. The detection signal may be heterodyne shifted to lower frequencies to allow easy and accurate measurement of phase and amplitude. Embodiments incorporating wavelength-swept, tunable, lasers and embodiments using broadband photonic fiber lasers with spectrally-sensitive detectors are described. | 10-21-2010 |
20130044185 | Operative Microscope Having Diffuse Optical Imaging System With Tomographic Image Reconstruction And Superposition In Field Of View - An imaging system has a microscope having an objective lens and a projection device configured to project spatially modulated light in one of several preselected predetermined pattern through the objective lens and onto tissue. The system camera configured to record an image of the tissue through the microscope and objective lens as illuminated by the spatially modulated light, and an image processor having a memory with a routine for performing spatial Fourier analysis on the image of the tissue to recover spatial frequencies. The image processor also constructs a three dimensional model of the tissue, and performs fitting of at least absorbance and scattering parameters of voxels of the model to match the recovered spatial frequencies. The processor then displays tomographic slices of the three dimensional model. | 02-21-2013 |
20130338479 | Apparatus And Method For Surgical Instrument With Integral Automated Tissue Classifier - A method and apparatus is described for optically scanning a field of view, the field of view including at least part of an organ as exposed during surgery, and for identifying and classifying areas of tumor within the field of view. The apparatus obtains a spectrum at each pixel of the field of view, and classifies pixels with a kNN-type or neural network classifier previously trained on samples of tumor and organ classified by a pathologist. Embodiments use statistical parameters extracted from each pixel and neighboring pixels. Results are displayed as a color-encoded map of tissue types to the surgeon. In variations, the apparatus provides light at one or more fluorescence stimulus wavelengths and measures the fluorescence light spectrum emitted from tissue corresponding to each stimulus wavelength. The measured emitted fluorescence light spectra are further used by the classifier to identify tissue types in the field of view. | 12-19-2013 |
20140114150 | Method And System For Using Cherenkov Radiation To Monitor Beam Profiles And Radiation Therapy - A system for providing monitored radiation therapy has a high energy radiation source, apparatus for excluding uncontrolled ambient light, and apparatus for collecting light emitted from a subject. The system has apparatus for spectrally analyzing the collected light, and a processor for determining oxygenation or other metabolic function of tissue within the subject from spectral analysis of the collected light. The system monitors radiation therapy by providing a beam of high energy radiation; collecting Cherenkov and/or photoluminescent light from the subject, the light generated along the beam; spectrally analyzing the light; and determining oxygenation or metabolic function of tissue from the spectral analysis. Beam profile of the system is calibrated by imaging from multiple angles Cherenkov and/or photoluminescent light emitted by a phantom placed in the beam in lieu of a subject, captured images are analyzed to determine beam profile. | 04-24-2014 |
20150150460 | Methods And Systems For Intraoperative Tumor Margin Assessment In Surgical Cavities And Resected Tissue Specimens - A tissue classifying system uses central illumination while detecting scattered light received from one or more rings surrounding the central illumination. A broadband illuminator is used. Received light couples to a spectrographic detection system that provides data to a processor with machine readable instructions for determining a classification of a type of tissue illuminated by the system. A scanner is used to generate a map of tissue classification for use by a surgeon who may remove additional tissue from a surgical wound to ensure complete treatment. Embodiments include a scanner that maps tissue classification across tissue, and a scanner coupled to a coherent optical bundle that may be placed in contact with tissue along boundaries of an operative wound. Other embodiments are adapted to scan tissue for fluorescent emissions and/or polarization shifts between incident and scattered light. | 06-04-2015 |
Greg Pogue, Austin, TX US
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20150184138 | PLANT-BASED RECOMBINANT BUTYRYLCHOLINESTERASE PRODUCTION METHODS - A new, reliable, easily scalable and reproducible method for the production of recombinant butyrylcholinesterase (rBuChE) is provided. Through the utilization of a plant transfection procedure, various plant strains have been shown to generate effective and scalable amounts of rBuChE under acceptable manufacturing processes to permit reliable levels of such enzymes for desired nerve agent protection requirements (including tetrameric products). As well, such methods in engineered plant lines have shown suitable production of these enzymes in tetramer form with glycan formation and sialyalation (for terminal groups) to allow for optimal potency against organophosphorus agent exposure as well as proper immunogenic response within the plant sources. The overall production method, including the transfection and production within mammalian cells, as well as the process steps involved for such a reliable sourcing platform from plants is thus encompassed within the invention. | 07-02-2015 |
Gregory P. Pogue, Austin, TX US
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20080213293 | Prevention and Treatment of Recurrent Respiratory Papillomatosis - Juvenile-onset recurrent respiratory papillomatosis is treated using active vaccination or passive immune therapy of neutralizing antibodies against HPV L2 neutralizing epitopes. | 09-04-2008 |
Gregory P. Pogue, Vacaville, CA US
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20090025106 | C-TERMINALLY TRUNCATED INTERFERON - The invention described herein provides a C-terminally truncated interferon having enhanced biological activity and the polynucleotides encoding such interferon. Also provided are methods for producing and using such truncated interferon. | 01-22-2009 |
20090208522 | Neutralizing Epitope-Based Growth Enhancing Vaccine - The invention provides a fusion protein comprising a plant virus coat protein and a GDF8 peptide domain, or antigenic fragment of the GDF8 peptide domain. Plant virus vectors expressing the fusion protein and methods of using these vectors are also provided. | 08-20-2009 |
James B. Pogue, St. Paul, MN US
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20090265274 | Automated Transaction Processing System and Approach with Currency Conversion - Transaction management for contract and contract-related approaches is facilitated. According to an example embodiment of the present invention, a transaction management system automatically sets contract terms including currency conversion terms for a transaction based on business rules previously established between parties to a transaction. In one implementation, the transaction management node automatically derives a contract term including a pricing-related term for a transaction between a buyer and seller using contract information therefor. The pricing-related term is used to set a price for the transaction, and a currency conversion term is used to convert the set price (or a portion of the set price corresponding to a particular transaction party) into a different currency. | 10-22-2009 |
Laura Pogue, Troy, MI US
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20110167013 | ONLINE CLASSROOM QUALITY CONTROL SYSTEM AND METHOD - A method of continuously improving an online course taught by an educational institution over a computer generated medium to a plurality of locations is disclosed. A minimum criteria is established and used to determine the quality of the online course taught through the computer generated medium. The online course sessions are monitored from a remote location through the computer generated medium at predetermined periodic intervals. Electronic reports are generated at the remote location and are provided to the educational institution during the online course via the electronic medium enabling the educational institution to make real time adjustments to the online course before the online course ends for improving the quality of the online course. | 07-07-2011 |
Lee E. Pogue, Kenosha, WI US
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20090260562 | Retractable Parking and Safety Cone and Method of Use - The present invention includes a retractable signaling apparatus and a method of using the apparatus to alert passers-by to the presence of a stationed vehicle that may be obscured from view. In situations that include the parking of a small vehicle or the stationing of such a vehicle along a road due to mechanical difficulties, it is often difficult for passers-by, including pedestrians and other motorists, to be aware of the presence of the vehicle. In such situations the present invention provides an easily carried signaling device that can be tethered to the vehicle. The signaling device provides an alert to passers-by of the presence of the vehicle in a timely manner such that collision with the vehicle can be avoided. The tethering means ensures that the alert is maintained in view of ambient conditions or mischief that could otherwise cause the loss of the alerting device. | 10-22-2009 |
Lynne Pogue, Menlo Park, CA US
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20150112959 | Search System Using Search Subdomain And Hints To Subdomains In Search Query Statements And Sponsored Results On A Subdomain-By-Subdomain Basis - A method and apparatus for generating search results including searching by subdomain and providing sponsored results by subdomain is provided. A search system according to embodiments of the present invention analyzes search queries to determine if they are to be routed to subdomains and presents results include sponsored hits sponsored on a subdomain by subdomain basis. | 04-23-2015 |
Lynne Pogue US
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20090157642 | SEARCH SYSTEM USING SEARCH SUBDOMAIN AND HINTS TO SUBDOMAINS IN SEARCH QUERY STATEMENTS AND SPONSORED RESULTS ON A SUBDOMAIN-BY-SUBDOMAIN BASIS - A method and apparatus for generating search results including searching by subdomain and providing sponsored results by subdomain is provided. A search system according to embodiments of the present invention analyzes search queries to determine if they are to be routed to subdomains and presents results include sponsored hits sponsored on a subdomain by subdomain basis. | 06-18-2009 |
20120330949 | Search System Using Search Subdomain and Hints to Subdomains in Search Query Statements and Sponsored Results on a Subdomain-By-Subdomain Basis - A method and apparatus for generating search results including searching by subdomain and providing sponsored results by subdomain is provided. A search system according to embodiments of the present invention analyzes search queries to determine if they are to be routed to subdomains and presents results include sponsored hits sponsored on a subdomain by subdomain basis. | 12-27-2012 |
Michael A. Pogue, Sunnyvale, CA US
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20130106806 | Bounding Box Based Control Method for Electronic Paper Devices | 05-02-2013 |
Michael Alan Pogue, Sunnyvale, CA US
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20150086033 | Reduced Latency Electronic Content System - An architecture for selecting and providing content items to a device includes cloud-based resources of a device management service and one or more content sources. The device is configured to receive instructions and a portion of the content item from the device management service. The instructions direct the device to obtain and buffer the content item from the content source, while simultaneously outputting the portion of the content item to a user. | 03-26-2015 |
Nathaniel Pogue, College Station, TX US
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20160049225 | QUENCH PROTECTED STRUCTURED SUPERCONDUCTING CABLE - Quench protected structured (QPS) superconducting cables, methods of fabricating the same, and methods of bending the same are disclosed. The methods of bending the QPS superconducting cables can be employed to produce windings. The QPS superconducting cables can rapidly drive a distributed quench to a normal conducting state in a superconducting cable if a region of the cable spontaneously quenches during high current operation. | 02-18-2016 |
Nathaniel J. Pogue, College Station, TX US
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20120028809 | Textured Powder Wires - A method for fabricating a wire from textured powder includes compressing a powder comprising a plurality of particles into a ribbon. The method further includes encasing the ribbon between two foil sheets to create a sheet of encased ribbon. The method additionally includes rolling the encased ribbon into a substantially cylindrical undrawn wire. The method further includes drawing the undrawn wire to create a substantially cylindrical wire having a diameter less than a diameter of the substantially cylindrical undrawn wire. | 02-02-2012 |
Rebecca Pogue, Morrisville, NC US
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20150132844 | Dendritic Cell Compositions and Methods - Methods are provided for the production of dendritic cells from monocytes that have been incubated at a temperature of 1° C.-34° C. for a period of approximately 6 to 96 hours from the time they are isolated from a subject. After the incubation period, the monocytes can then be induced to differentiate into dendritic cells. Mature dendritic cells made by the methods of the invention have increased levels of one or more of CD80, CD83, CD86, MHC class I molecules, or MHC class II molecules as compared to mature dendritic cells prepared from monocytes that have not been held at 1° C.-34° C. for at least 6 hours from the time they were isolated from a subject. Dendritic cells made by the methods of the invention are useful for the preparation of vaccines and for the stimulation of T cells. | 05-14-2015 |
20160102291 | Dendritic Cell Compositions and Methods - Methods are provided for the production of dendritic cells from monocytes that have been incubated at a temperature of 1° C.-34° C. for a period of approximately 6 to 96 hours from the time they are isolated from a subject. After the incubation period, the monocytes can then be induced to differentiate into dendritic cells. Mature dendritic cells made by the methods of the invention have increased levels of one or more of CD80, CD83, CD86, MHC class I molecules, or MHC class II molecules as compared to mature dendritic cells prepared from monocytes that have not been held at 1° C.-34° C. for at least 6 hours from the time they were isolated from a subject. Dendritic cells made by the methods of the invention are useful for the preparation of vaccines and for the stimulation of T cells. | 04-14-2016 |
Richard Pogue, San Diego, CA US
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20090172051 | ONLINE INCREMENTAL DATABASE DUMP - Various embodiments may include taking an initial dump of a database table and tracking changes to the database table, with regard to but outside of transactions, since a most recent full or partial dump has been taken. A partial dump, in such embodiments, may be taken since the most recent full or partial dump and used to create a data structure which may be used to update only those database table rows modified since a last full or partial dump. As a result, the dumps of a database table will include a single full dump and may include one or more partial dumps. These full and partial dumps may then be instantiated to create or update an instance of the database table. In some embodiments, dumps may be taken directly to a mirrored instance of a database table. | 07-02-2009 |
Richard W. Pogue, St. Peters, MO US
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20090010747 | PULL AND LIFT SYSTEM FOR TRANSPORTING ROOFING MATERIALS - The pull and lift system of the present invention transfers roofing materials from the pullbar extended position | 01-08-2009 |
20090294246 | EXTENDIBLE CONVEYOR SYSTEM - A conveyor system includes an extension section that slides inwardly and telescopes outwardly of a main section of conveyor. The extension motion is powered by at least one hydraulic ram. The conveyor has a stem that lowers to a loadable height by the retraction of double hydraulic rams upon a steel internal core. The conveyor then lifts vertically in a cantilevered manner upon a vertical ram and then rotates 360 degrees parallel to the plane of a truck bed using a cooperating gear plate and a hydraulic motor with a chain. Paddles push material secured to a chain drive or alternately a belt and the chain drive or belt moves through a series of sprockets or rollers in a continuous manner. The paddles eventually return to their initial location. | 12-03-2009 |
20110064551 | PULL AND LIFT SYSTEM FOR TRANSPORTING ROOFING MATERIALS - The pull and lift system for transporting roofing materials includes a pull bar upon a flat bed of a truck, two rams connecting to the pull bar, controls for the rams, two pairs of mutually spaced apart legs, a table connecting between the pairs of legs, at least one ram connecting to the table, and controls for this ram. The first controls engage the pull bar against a pallet then draw it towards the table. The pull bar has an L shaped cross section with the lower portion sliding upon the flat bed and the upper portion engaging a pallet. The table has a first position coplanar with the flat bed and a second position above the flat bed and proximate a conveyor. The table elevates, while loaded with cargo, and remains level during its transition from the first position to the second position. | 03-17-2011 |
Robert T. Pogue, Pittsburgh, PA US
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20080274327 | ALDIMINES OR KETIMINES FOR IMPROVED ADHESION OF UV CLEARS - A coating system for application to a porous substrate such as wood is disclosed. The coating system comprises a color-imparting stain or toner and a UV-curable clear coat. The stain and/or toner contains an aldimine or a ketimine that improves the adhesion of the coating system to the substrate. | 11-06-2008 |
20080295869 | APPARATUS AND METHOD FOR CLEANING OUTDOOR SURFACES - The present invention is directed to an apparatus and method for cleaning outdoor surfaces. The apparatus includes a cleaning element attached to a handle which also supports a reservoir for cleaning fluid. The cleaning element includes absorbent and scrubbing layers structured to clean various types of outdoor surfaces. A cleaning fluid is applied by a liquid delivery system in fluid communication with the cleaning element to the outdoor surface to be cleaned and the outdoor surface is wiped with the cleaning apparatus. | 12-04-2008 |
20120214928 | WATERBORNE COMPOSITIONS AND THEIR USE AS PAINTS AND STAINS - Waterborne compositions comprising an aqueous dispersion comprising a latex are disclosed. Disclosed are latexes that are the reaction product of reactants that include a ureido-functional ethylenically unsaturated compound, an ethylenically unsaturated silicone, and another ethylenically unsaturated compound. Use of such composition to treat porous substrate is also disclosed. | 08-23-2012 |
Russell Pogue, Del Mar, CA US
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20150043977 | INTERLOCKING SHORING PANELS - The present invention is an interlocking shoring panel for excavation with implied methods of use. In one preferred embodiment the panel comprises a top edge, a bottom edge, a first side edge, a second side edge, an inner surface and an outer surface. The edges have attachment means such as complementary interlocking features for connecting the panel to one or more adjacent shoring panels. The inner surfaces have two or more horizontal channels and two or more vertical support struts at spaced intervals along the length of the shoring panel. A plurality of shoring panels are interconnected to form a shoring ring, and a plurality of shoring rings are interconnected to form a shoring structure. | 02-12-2015 |
Russell L. Pogue, San Diego, CA US
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20100209199 | INTERLOCKING SHORING PANEL AND METHODS OF USE THEREOF - The present invention is an interlocking shoring panel for excavation and methods of use. In one preferred embodiment the panel comprises a top edge, a bottom edge, a first side edge, a second side edge, an inner surface and an outer surface. The edges have attachment means such as complementary interlocking features for connecting the panel to one or more adjacent shoring panels. The inner surface having two or more horizontal channels and two or more vertical support struts at spaced intervals along the length of the shoring panel. A plurality of shoring panels are interconnected to form a shoring ring, and a plurality of shoring rings are interconnected to form a shoring structure. | 08-19-2010 |
Sarah L. Pogue, Milpitas, CA US
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20100158902 | MONOCLONAL ANTIBODIES AGAINST STROMAL DERIVED FACTOR-1 (SDF-1) - The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to SDF-1 with high affinity. Nucleic acid molecules encoding SDF-1 antibodies, expression vectors, host cells and methods for expressing the SDF-1 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the SDF-1 antibodies are also provided. Methods for detecting SDF-1, as well as methods for treating various B cell malignancies, including breast cancer, multiple myeloma and non-Hodgkin's lymphoma, and autoimmune disorders are disclosed. | 06-24-2010 |
Sarah L. Pogue, Freemont, CA US
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20140248238 | POLYPEPTIDE CONSTRUCTS AND USES THEREOF - The present invention provides a polypeptide construct comprising a peptide or polypeptide signaling ligand linked to an antibody or antigen binding portion thereof which binds to a cell surface-associated antigen, wherein the ligand comprises at least one amino acid substitution or deletion which reduces its potency on cells lacking expression of said antigen. | 09-04-2014 |
Sarah L. Pogue, Fremont, CA US
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20110262448 | HUMAN ANTIBODIES THAT BIND MESOTHELIN, AND USES THEREOF - The present disclosure provides isolated monoclonal antibodies that specifically bind to mesothelin with high affinity, particularly human monoclonal antibodies. Preferably, the antibodies bind human mesothelin. In certain embodiments, the antibodies are capable of internalizing into mesothelin-expressing cells or are capable of mediating antigen dependent cellular cytotoxicity. The invention further provides anti-mesothelin antibodies that can inhibit the binding of mesothelin to the ovarian cancer antigen CA125. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting mesothelin, as well as methods for treating cancers, such as mesotheliomas, pancreatic cancers and ovarian cancers, using an anti-mesothelin antibody of this disclosure. | 10-27-2011 |
20130028904 | HUMAN ANTIBODIES THAT BIND MESOTHELIN, AND USES THEREOF - The present disclosure provides isolated monoclonal antibodies that specifically bind to mesothelin with high affinity, particularly human monoclonal antibodies. Preferably, the antibodies bind human mesothelin. In certain embodiments, the antibodies are capable of internalizing into mesothelin-expressing cells or are capable of mediating antigen dependent cellular cytotoxicity. The invention further provides anti-mesothelin antibodies that can inhibit the binding of mesothelin to the ovarian cancer antigen CA125. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting mesothelin, as well as methods for treating cancers, such as mesotheliomas, pancreatic cancers and ovarian cancers, using an anti-mesothelin antibody of this disclosure. | 01-31-2013 |
20130028905 | HUMAN ANTIBODIES THAT BIND MESOTHELIN, AND USES THEREOF - The present disclosure provides isolated monoclonal antibodies that specifically bind to mesothelin with high affinity, particularly human monoclonal antibodies. Preferably, the antibodies bind human mesothelin. In certain embodiments, the antibodies are capable of internalizing into mesothelin-expressing cells or are capable of mediating antigen dependent cellular cytotoxicity. The invention further provides anti-mesothelin antibodies that can inhibit the binding of mesothelin to the ovarian cancer antigen CA125. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting mesothelin, as well as methods for treating cancers, such as mesotheliomas, pancreatic cancers and ovarian cancers, using an anti-mesothelin antibody of this disclosure. | 01-31-2013 |
20130028906 | HUMAN ANTIBODIES THAT BIND MESOTHELIN, AND USES THEREOF - The present disclosure provides isolated monoclonal antibodies that specifically bind to mesothelin with high affinity, particularly human monoclonal antibodies. Preferably, the antibodies bind human mesothelin. In certain embodiments, the antibodies are capable of internalizing into mesothelin-expressing cells or are capable of mediating antigen dependent cellular cytotoxicity. The invention further provides anti-mesothelin antibodies that can inhibit the binding of mesothelin to the ovarian cancer antigen CA125. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting mesothelin, as well as methods for treating cancers, such as mesotheliomas, pancreatic cancers and ovarian cancers, using an anti-mesothelin antibody of this disclosure. | 01-31-2013 |
20130190481 | HUMAN ANTIBODIES THAT BIND MESOTHELIN, AND USES THEREOF - The present disclosure provides isolated monoclonal antibodies that specifically bind to mesothelin with high affinity, particularly human monoclonal antibodies. Preferably, the antibodies bind human mesothelin. In certain embodiments, the antibodies are capable of internalizing into mesothelin-expressing cells or are capable of mediating antigen dependent cellular cytotoxicity. The invention further provides anti-mesothelin antibodies that can inhibit the binding of mesothelin to the ovarian cancer antigen CA125. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting mesothelin, as well as methods for treating cancers, such as mesotheliomas, pancreatic cancers and ovarian cancers, using an anti-mesothelin antibody of this disclosure. | 07-25-2013 |
20160068612 | ANTI-CD38 ANTIBODIES AND FUSIONS TO ATTENUATED INTERFERON ALPHA-2B - Antibodies that specifically bind to CD38, as well as constructs comprising such antibodies fused to attenuated interferon alpha-2B proteins are provided. Anti-CD38-attenuated interferon alpha-2b fusion constructs may be used to inhibit proliferation in cancerous cells that express both CD38 and the receptor for IFN-alpha2b, as well as to induce apoptosis in such cells. Inhibition of proliferation and induction of apoptosis in cancerous cells may serve as the basis for the treatment of the underlying cancer. | 03-10-2016 |
Sarah L. Pogue, Frazer, PA US
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20150313965 | Combination of Lenalidomide and Polypeptide Construct, and Uses Thereof - Methods for cancer treatment include administering to a cancer patient an anti-CD38 antibody-attenuated human IFN alpha-2b construct and lenalidomide or pomalidomide. Tumors that may be treated according to these methods include tumors which comprise CD-38 expressing tumor cells, including B-cell lymphoma, multiple myeloma, non-Hodgkin's lymphoma, chronic myelogenous leukemia, chronic lymphocytic leukemia, and acute lymphocytic leukemia. | 11-05-2015 |
Sarah Lee Pogue, Fremont, CA US
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20100104569 | HUMANIZED ANTIBODIES TO INTERFERON ALPHA RECEPTOR-1 (IFNAR-1) - Humanized monoclonal antibodies which bind to IFNAR-1, and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the humanized antibodies and therapeutic and diagnostic methods for using the humanized antibodies. | 04-29-2010 |
20110086422 | HUMANIZED ANTIBODIES TO INTERFERON ALPHA RECEPTOR-1 (IFNAR-1) - Humanized monoclonal antibodies which bind to IFNAR-1, and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the humanized antibodies and therapeutic and diagnostic methods for using the humanized antibodies. | 04-14-2011 |
Sydney E. Pogue, Oklahoma City, OK US
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20090194729 | DISCHARGE VALVE FOR DOWNHOLE PUMPS - A discharge valve comprising a valve body, a valve member, and a valve seat. The valve body has a first end; a second end; a central axis therebetween; an inlet formed through the first end; a flow channel extending from the inlet to the second end; a valve channel extending from the inlet and terminating within the valve body; and at least one discharge port extending from the valve channel to an outer surface of the valve body. The valve member is substantially-spherical and movably disposed within the valve channel. The valve seat is disposed adjacent the first end of the valve channel. The valve seat has an orifice defined therethrough The valve member is movable between a first position, engaging the valve seat to substantially seal the orifice, and a second position adjacent the second end of the valve channel to permit fluid to flow through the orifice. | 08-06-2009 |
20090196779 | BYPASS VALVE AND DOWNHOLE PUMP - A pump comprising a body assembly and a plunger assembly slidably received in the body assembly. The body assembly comprises a standing valve, a discharge valve, and a pump barrel cooperating to define a pump chamber. The standing valve opens to permit fluid to flow into the pump chamber from outside the tubing responsive to a negative pressure gradient across the standing valve. The discharge valve opens to permit fluid to flow out of the pump chamber and into the tubing responsive to a positive pressure gradient across the discharge valve. | 08-06-2009 |