Patent application number | Description | Published |
20120202447 | Method and/or Apparatus for Location Privacy Via Uniform Resource Identifier Provisioning - The subject matter disclosed herein relates in one particular implementation to a method, apparatus, and/or system for transmitting, by a location server, a location identifier to a mobile device. The location identifier may be transmitted from the mobile device to one or more trusted entities. Access to a location estimate of the mobile device may be selectively authorized at least partially in response to a request received at the mobile device from the location server including the location identifier. | 08-09-2012 |
20120202517 | Methods and Apparatus for Identifying and Authorizing Location Servers and Location Services - Techniques are provided which may be implemented in various methods, apparatus, and/or articles of manufacture to allow a mobile device to obtain certain location service(s) and/or the like from one or more computing devices that have been authorized for use. For example, in certain implementations, an authorizing location server may obtain a first message from a mobile device indicating a first set of location servers, determine a second set of location servers based, at least in part, on the first set of location servers, and transmit a second message to the mobile device indicating that the second set of location servers are authorized for location service related access by the mobile device. | 08-09-2012 |
20120244852 | SEGMENTED DATA TRANSFER WITH RESUME CAPABILITY - A large volume of location related information, e.g., assistance data or location information, is transferred in separate messages between a server and a target by segmenting the location related information into a plurality of messages. If the connection between the server and target is released prior to completion of the transfer of the location related information, the transfer is resumed by sending the remaining messages after connection is reestablished. Each message is sent after receiving an acknowledgement of receipt. Thus, both the server and target can control the flow of the transfer by delaying the sending of one or more messages or delaying the sending of the acknowledgements of receipt. | 09-27-2012 |
20130212649 | SECURE MECHANISM FOR OBTAINING AUTHORIZATION FOR A DISCOVERED LOCATION SERVER - Methods and apparatuses are presented for obtaining authorized access from a terminal to a discovered location server. The methods may include switching from a first network that does not support authenticated access from the terminal to a home location server to a second network that does support authenticated access from the terminal to the home location server. Authenticated access to the home location server may be obtained using the second network. Authorization for the discovered location server may then be obtained from the home location server. The terminal may then switch from the second network back to the first network. The terminal may then access the discovered location server using the first network based on the obtained authorization from the home location server. | 08-15-2013 |
20130212663 | ENABLING SECURE ACCESS TO A DISCOVERED LOCATION SERVER FOR A MOBILE DEVICE - A method for obtaining a secure connection between a first server and a client. The method may comprise establishing a secure communication session between a second server and the client, wherein the second server is trusted by the first server, and the second server is configured to authenticate the client. The client may receive a client token, wherein the client token contains data associated with the first server, the second server, the client, and a digital signature. Then, the client may request secure communication access to the first server, wherein the request includes transferring the client token to the first server. Finally, the client may receive a grant of secure communication access to the first server based on authentication of the client by the first server, wherein the authentication is based on the client token validating the client and the digital signature validating the client token. | 08-15-2013 |
20130217415 | SECURE USER PLANE LOCATION (SUPL) REDIRECTION AND MOBILE LOCATION PROTOCOL (MLP) TUNNELING TO A DISCOVERED SLP - Systems and methods for Secure User Plane (SUPL) Redirection and Mobile Location Protocol (MLP) Tunneling to a Discovered SUPL Location Platform (D-SLP) are disclosed. For example, a method for SUPL redirection by a SET, may include: receiving an initiation message at a SET from a Home SUPL Location Platform (H-SLP); establishing a secure connection with the H-SLP, and returning a response message; receiving a redirect message from the H-SLP; establishing a SET initiated SUPL session with a D-SLP; obtaining a location of the SET using the D-SLP; and returning the location to the H-SLP. | 08-22-2013 |
20130225170 | SECURE USER PLANE LOCATION (SUPL) REDIRECTION AND MOBILE LOCATION PROTOCOL (MLP) TUNNELING TO A DISCOVERED SLP - Systems and methods for Secure User Plane (SUPL) Redirection and Mobile Location Protocol (MLP) Tunneling to a Discovered SUPL Location Platform (D-SLP) are disclosed. For example, a method for SUPL redirection by a SET, may include: receiving an initiation message at a SET from a Home SUPL Location Platform (H-SLP); establishing a secure connection with the H-SLP, and returning a response message; receiving a redirect message from the H-SLP; establishing a SET initiated SUPL session with a D-SLP; obtaining a location of the SET using the D-SLP; and returning the location to the H-SLP. | 08-29-2013 |
20130281007 | LOCATION AND TIME BASED FILTERING OF BROADCAST INFORMATION - Techniques for sending and receiving broadcast information are described. In an aspect, broadcast metadata may be generated for broadcast information and may include location and time criteria used by terminals to filter the broadcast information. Each location and time criterion may include (i) a location criterion given by a target location and a presence or absence requirement and (ii) a time criterion given by a time period in which the location criterion applies. A terminal may receive the broadcast metadata prior to or with the broadcast information, obtain location and time criteria from the broadcast metadata, and filter the broadcast information based on the location and time criteria. The terminal may evaluate each location and time criterion by determining its location within a specified time period and determining whether its location is within or outside a specified target location, as indicated by the presence or absence requirement. | 10-24-2013 |
20130283352 | METHODS, APPARATUSES AND ARTICLES FOR IDENTIFYING AND AUTHORIZING LOCATION SERVERS AND LOCATION SERVICES USING A PROXY LOCATION SERVER - Techniques are provided which may be implemented in various methods, apparatus, and/or articles of manufacture to allow a mobile device to obtain certain location service(s) and/or the like from one or more computing devices that have been authorized for use. For example, in certain implementations, a location server may comprise a proxy location server for an authorizing location server and may indicate one or more other location servers as being authorized for location service related access by a mobile device. | 10-24-2013 |
20130316742 | Method and apparatus for transmitting indoor context information - The subject matter disclosed herein relates to a system and method for determining indoor context information relating to a location of a mobile device. Indoor context information may be utilized by a mobile device or a network element to obtain an estimate of a location of the mobile device within an indoor environment. | 11-28-2013 |
20130317778 | Method and apparatus for transmitting indoor context information - The subject matter disclosed herein relates to a system and method for determining indoor context information relating to a location of a mobile device. Indoor context information may be utilized by a mobile device or a network element to obtain an estimate of a location of the mobile device within an indoor environment. | 11-28-2013 |
20130339478 | INDOOR LOCATION SERVER PROVISION AND DISCOVERY - Systems and methods are presented for discovering a local location server associated with a local provider based on a relationship between the local provider and another regional/global provider. A mobile device discovers the local provider and queries a home location server which returns the address of a regional/global location server associated with the regional/global provider. A mobile device then queries the regional/global location server to discover the local location server and may then access the local location server to obtain location services. The method may be employed with the OMA SUPL location solution wherein the home location server may be an H-SLP and the local and regional/global location servers may be D-SLPs. | 12-19-2013 |
20140080523 | Method and apparatus for performing session info query for user plane location - Techniques for querying for information on location sessions in a user plane location architecture are described. In an aspect, a location server may send a query message to a terminal to query for information on active location sessions, e.g., when at least one location session for periodic triggered service or area event triggered service is deemed to be active. The terminal may return a response message containing a list of session identifiers (IDs) for the active location sessions, parameters for the active location sessions, capabilities of the terminal, etc. The location server may compare the information received from the terminal and information stored at the location server. The location server may terminate each location session deemed to be active at only the terminal or only the location server. The location server may restart or terminate each location session having inconsistent parameters at the terminal and the location server. | 03-20-2014 |
20140093081 | AUTHENTICATION IN SECURE USER PLANE LOCATION (SUPL) SYSTEMS - A particular method includes receiving, at a secure user plane location (SUPL) server, an indication from a mobile device of one or more transport layer security (TLS) cipher suites supported by the mobile device; determining whether the one or more TLS cipher suites include a TLS pre-shared key (TLS-PSK) cipher suite that is supported by the SUPL server; in response to determining whether the one or more TLS cipher suites include the TLS-PSK cipher suite that is supported by the SUPL server, performing a generic bootstrapping architecture (GBA)-based authentication process to authenticate the mobile device, or determining whether the SUPL server supports a certificate-based authentication method; and in response to determining that the SUPL server supports the certificate-based authentication method, performing the certificate-based authentication method that includes sending a server certificate to the mobile device and receiving a device certificate from the mobile device. | 04-03-2014 |
20140094147 | AUTHENTICATION IN SECURE USER PLANE LOCATION (SUPL) SYSTEMS - A particular method includes generating, at a secure user plane location (SUPL) server, a message to be sent to a mobile device, the message including: a server certificate including an identifier of the SUPL server and a public key of the SUPL server; and a request for a device certificate of the mobile device. The method also includes receiving a reply from the mobile device that includes a device certificate of the mobile device; and authenticating the mobile device as associated with a SUPL user based on the device certificate. | 04-03-2014 |
20140135040 | Techniques for generating environment and reference data reports for particular environments on behalf of mobile devices - Various methods, apparatuses and/or articles of manufacture are provided which may be implemented using one or more fixed electronic devices to generate a reference data report corresponding to a particular environment. Various methods, apparatuses and/or articles of manufacture are provided which may be implemented using one or more mobile electronic devices to generate an environment report corresponding to a particular environment. | 05-15-2014 |
20140155101 | POSITION LOCATION MESSAGE FLOWS - Techniques for initiating and, if desired, modifying location services for Secure User Plane Location (SUPL) and other location architectures are described. To initiate SUPL service, a SUPL Location Platform (SLP) transmits a SUPL initial session message applicable to any service request to a SUPL enabled terminal (SET) and receives in response the service capabilities of the SET. The SLP selects and requests service from the SET consistent with the service capabilities of the SET. The SET may initiate SUPL service by requesting the service capabilities of the SLP. The SET selects and requests service from the SLP that is consistent with the service capabilities received from the SLP. The SET and SLP communicate to determine a position estimate for the SET. The service may be modified before or while communicating between the SET and the SLP to determine a position estimate for the SET. | 06-05-2014 |
20140162693 | METHODS AND SYSTEMS FOR PROVIDING LOCATION BASED SERVICES IN A VENUE - Disclosed are systems, methods and devices for application of location based services in a venue using mobile centric and network centric positioning techniques. In particular, call message flows are described for specific use cases. In one particular implementation, a system obtains estimated locations of mobile devices to provide location aware content to applications hosted on the mobile devices. In another implementation, a system may gather statistics regarding mobile devices' entry into, departure from or movement within a venue for development of user analytics. | 06-12-2014 |
20140200032 | METHOD AND APPARATUS FOR CONFIGURING SECURE USER PLANE LOCATION (SUPL) ENABLED TERMINALS - Methods, systems, computer-readable media, and apparatuses are disclosed for providing location services to an application in a Secure User Plane Location (SUPL) Enabled Terminal (SET). In some embodiments, a SUPL configuration server (SUPL CS) may configure multiple secure user plane location (SUPL) location platforms (SLPs) in a first stage. Subsequently, the SUPL CS may configure information independently for the application in a second stage, wherein the configuration information for the application includes identification of a particular Home SLP (H-SLP) configured in the first stage. | 07-17-2014 |
20140200846 | ACCESS NETWORK NODE BASED BAROMETRIC REFERENCE PRESSURE NETWORK - Systems, apparatus and methods for populating and using a pressure database to determine an altitude of a unit with an unknown altitude are presented. A pressure from one or more barometric pressure sensors linked to respective base stations are interpolated to determine a reference pressure (e.g., at sea level) at arbitrary coordinates (x,y) having pressure reading. For example, a mobile station at the arbitrary coordinates (x,y) records a pressure at the mobile station. A difference between this pressure at the mobile station and the interpolated reference pressure is determined, which may directly be interpreted as a defined altitude of the mobile station. | 07-17-2014 |
20140221019 | METHODS AND APPARATUS FOR IDENTIFYING AND AUTHORIZING LOCATION SERVERS AND LOCATION SERVICES - Techniques are provided which may be implemented in various methods, apparatus, and/or articles of manufacture to allow a mobile device to obtain certain location service(s) and/or the like from one or more computing devices that have been authorized for use. For example, in certain implementations, an authorizing location server may obtain a first message from a mobile device indicating a first set of location servers, determine a second set of location servers based, at least in part, on the first set of location servers, and transmit a second message to the mobile device indicating that the second set of location servers are authorized for location service related access by the mobile device. | 08-07-2014 |
20140235208 | METHOD AND APPARATUS FOR USING SERVICE CAPABILITY INFORMATION FOR USER PLANE LOCATION - Techniques for supporting location services in a user plane location architecture such as Secure User Plane Location (SUPL) are described. In an aspect, a terminal informs a location server of service capabilities of the terminal. The location server uses the service capabilities to request only location services supported by the terminal and to avoid requesting unsupported location services. The terminal generates a message containing its service capabilities and sends the message via a user plane, e.g., SUPL. The location server receives the message, obtains the service capabilities of the terminal, and stores these service capabilities for future network-initiated location sessions with the terminal. The location server determines whether a location service is supported by the terminal based on the service capabilities of the terminal. The location server communicates with the terminal via the user plane for the location service if supported by the terminal. | 08-21-2014 |
20140235266 | Focused assistance data for WiFi access points and femtocells - Systems, apparatus and methods for reducing a long list of access points (APs) to a short list of access points are presented. Advantageously, a mobile device only needs to search for and measure access points on the short list to determine a position fix, thereby saving battery power, reducing a time to fix and/or improving location accuracy. Embodiments enable a mobile device to determine which access points should be detectable at a new location of the mobile device. Various embodiments comprise using: (1) linked APs; (2) grouped APs; (3) associated APs; and (4) feedback on APs. | 08-21-2014 |
20140256323 | Methods and Systems for Responding to Handover Events During Positioning Sessions - Disclosed are systems, methods and devices for responding to changes in a wireless access type occurring in connection with a handover event affecting a mobile terminal while the mobile terminal is engaged in a position determination session with a location server. If a first positioning protocol employed in the position determination session is not supported or enabled by the changed wireless access type, the position determination session may be resumed or restarted using a second positioning protocol supported or enabled by the changed wireless access type. | 09-11-2014 |
20140274135 | CLIENT ACCESS TO MOBILE LOCATION SERVICES - A method of providing location services at a location server for a venue includes: receiving a request for location service, where the request for location service comprises at least one of a first identification of at least one mobile device or an identification of a target area; and sending a response, where the response comprises at least one of a second identification of at least one mobile device or an identification of a geographic area, where at least one of the first identification of at least one mobile device, the second identification of at least one mobile device, the identification of the target area, or the identification of the geographic area comprises a venue-specific identification. | 09-18-2014 |
20140274136 | CLIENT ACCESS TO MOBILE LOCATION SERVICES - A method of providing location services at a location server for a venue includes: receiving a request for location service for one or more mobile devices, where the request for location service comprises a trigger condition and at least one of a group condition or a persistence condition; determining the occurrence of the trigger condition and at least one of the group condition or the persistence condition; and sending a response, where the response indicates the occurrence of the trigger condition and at least one of the group condition or the persistence condition. | 09-18-2014 |
20140282865 | DYNAMIC H-SLP ALLOCATION FOR SET INITIATED SUPL SERVICES - Methods, systems, computer-readable media, and apparatuses for accessing services from multiple home Secure User Plane Location (SUPL) Platforms.(H-SLP) servers are provided. In one potential embodiment, a method describes identifying in an application identifier list, a fully qualified domain (FQDN) name associated with the application from a plurality of FQDNs. A subsequent request for services by a different application on the device may identify a different FQDN associated with a different H-SLP to provide services to the device for the second application. | 09-18-2014 |
20140304420 | METHOD FOR SECURE USER PLANE (SUPL) VERSION NEGOTIATION - The subject matter disclosed herein relates to a system and method for negotiating a version of Secure User Plane Location (SUPL) between a network entity and a SUPL enabled terminal. In a particular implementation, a SUPL initiation message is transmitted from a network entity to a SUPL entity, where the SUPL initiation message identifies a plurality of SUPL versions capable of supporting a desired service. A response is received from the SUPL entity that is based, at least in part, on an ability of the SUPL entity to support at least one of the plurality of versions. | 10-09-2014 |
20140342751 | METHOD AND APPARATUS FOR USING HISTORIC NETWORK INFORMATION FOR DETERMINING APPROXIMATE POSITION - Systems and techniques to determine an approximate location for a mobile device using historic location information. In an aspect, a SUPL Location Platform (SLP), which is a location server in SUPL, may receive data from SUPL Enabled Terminal (SET). The data may include the Multiple Location IDs Parameter. The real time Location ID Parameter may not have a current status. The SLP may determine an approximate position for the SET based on the Multiple Location IDs Parameter data received from the SET. The SLP may then send the approximate position to the SET or a SUPL Agent, or may use the approximate position information in another way. | 11-20-2014 |
20140349605 | METHOD AND/OR APPARATUS FOR LOCATION PRIVACY VIA UNIFORM RESOURCE IDENTIFIER PROVISIONING - The subject matter disclosed herein relates in one particular implementation to a method, apparatus, and/or system for transmitting, by a location server, a location identifier to a mobile device. The location identifier may be transmitted from the mobile device to one or more trusted entities. Access to a location estimate of the mobile device may be selectively authorized at least partially in response to a request received at the mobile device from the location server including the location identifier. | 11-27-2014 |
20140351886 | METHODS AND APPARATUSES FOR PROTECTING POSITIONING RELATED INFORMATION - Various methods, apparatuses and articles of manufacture are provided which may be implemented to authenticate the provider of a positioning engine provisioned within a mobile station to enable the positioning engine to obtain and use protected positioning assistance data. In certain examples, a relationship between the provider of a location server and the provider of a positioning engine provisioned within a mobile station may be authenticated, and protected positioning data may be obtained from said positioning engine by said location server. | 11-27-2014 |
20150031323 | APPARATUS AND METHOD TO IMPLEMENT A QUEUING PROCESS BY A POSITION ENABLED MOBILE DEVICE TO PRIORITIZE THE LEGITIMACY OF INITIATION MESSAGES FROM EMERGENCY LOCATION PLATFORMS - Disclosed is an apparatus and method to implement a queuing process by a position enabled mobile device to prioritize the legitimacy of initiation messages. The method may include: transmitting an emergency call; receiving at least one initiation message; and assigning the received initiation message to one of a plurality of priority queues, wherein the assignment to the priority queue is based upon at least one of an identifier of an emergency location platform or a whitelist. | 01-29-2015 |
Patent application number | Description | Published |
20080207746 | Intracorporeal medicaments for photodynamic treatment of disease - New intracorporeal photodynamic medicaments and certain medical uses and methods for use of such photodynamic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations including liquid, semisolid, solid or aerosol delivery vehicles. | 08-28-2008 |
20080311035 | Diagnostic Agents For Positron Emission Imaging Using Radiolabeled Halogenated Xanthenes - New diagnostic agents for positron emission tomography (PET) and methods for use of such agents for imaging of human or animal tissue are described, wherein a primary active component of such agents is a radiolabeled halogenated xanthene or halogenated xanthene derivative. Preferably, the radiolabeled halogenated xanthene is radiolabeled Rose Bengal or a functional derivative of Rose Bengal. | 12-18-2008 |
20090117199 | Method of treatment of cancer - A method for the treatment of cancer, particularly a metastatic melanoma or a neoplastic lesion, the method comprising intralesional administration of a hydrophilic vehicle comprising 4,5,6,7-Tetrachloro-2′,4′,5′,7′-tetraiodofluorescein, or a physiologically acceptable salt thereof, at a concentration of about 0.1 w/v % up to about 20 w/v % and an electrolyte comprising at least one cation selected from the group consisting of sodium, potassium, calcium and magnesium and at least one anion selected from the group consisting of chlorine, a phosphate and a nitrate, wherein the electrolyte is at a concentration of between about 0.1 w/v % and about 2 w/v % and the pH of the solution between about 4 to about 10. | 05-07-2009 |
20100076246 | Intracorporeal Medicaments for High Energy Phototherapeutic Treatment of Disease - New intracorporeal radiodense medicaments and certain medical uses and methods for use of such high energy phototherapeutic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. The halogenated xanthenes constitute a family of potent radiosensitizers that become photoactivated upon irradiation of the treatment site with ionizing radiation. In embodiments of the present invention, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another embodiment, such medicaments are produced in various formulations including liquid, semisolid, solid or aerosol delivery vehicles. | 03-25-2010 |
20110071217 | Process for the Synthesis of 4,5,6,7-tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodo-3H-spiro[isoben- zofuran-1,9'-xanthen]-3-one (Rose Bengal) and Related Xanthenes - A new process for the manufacture of iodinated xanthenes in high purity includes a cyclization step followed by an iodination step. No extraction, chromatographic or solvent concentration steps are required, and the intermediate as well as final compounds are isolated via filtration or similar means. The process requires a single organic solvent, and the steps are completed at temperatures below 100° C. The exclusion of chloride ions, of chloride free-radicals, hypochlorite ions, or hypochlorous acid as reagents or from reagents that may generate these species in situ in the presence of oxidants, prevents undesirable impurity formation. Several new compounds have been conceived and isolated using these methods. These new compounds are also formed into new medicaments. | 03-24-2011 |
20110097280 | Intracorporeal Medicaments for Photodynamic Treatment of Disease - New intracorporeal photodynamic medicaments and certain medical uses and methods for use of such photodynamic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations including liquid, semisolid, solid or aerosol delivery vehicles. | 04-28-2011 |
20120263677 | Combination of Local and Systemic Immunomodulative Therapies for Enhanced Treatment of Cancer - A method for the treatment of cancer comprising administration of a therapeutically effective amount of an intralesional chemoablative pharmaceutical composition, or variant of said composition, in combination with a therapeutically effective amount of a systemic immunomodulatory anticancer agent. A further method for the treatment of cancer comprising administration of a therapeutically effective amount of an intralesional chemoablative pharmaceutical composition, or variant of said composition, in combination with a therapeutically effective amount of a systemic targeted anticancer agent. The present invention is further directed to pharmaceutical compositions for treatment of cancer. The intralesional chemoablative pharmaceutical composition can comprise an IL chemoablative agent comprising primarily a halogenated xanthene. | 10-18-2012 |
20130274322 | Process for the Synthesis of 4,5,6,7-tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodo-3H-spiro[isoben- zofuran-1,9'-xanthen]-3-one(Rose Bengal) and Related Xanthenes - A new process for the manufacture of iodinated xanthenes in high purity includes a cyclization step followed by an iodination step. No extraction, chromatographic or solvent concentration steps are required, and the intermediate as well as final compounds are isolated via filtration or similar means. The process requires a single organic solvent, and the steps are completed at temperatures below 100° C. The exclusion of chloride ions, of chloride free-radicals, hypochlorite ions, or hypochlorous acid as reagents or from reagents that may generate these species in situ in the presence of oxidants, prevents undesirable impurity formation. Several new compounds have been conceived and isolated using these methods. These new compounds are also formed into new medicaments. | 10-17-2013 |
20140343296 | Process for the Synthesis of 4,5,6,7-tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodo-3H-spiro[isoben- zofuran-1,9'-xanthen]-3-one (Rose Bengal) and Related Xanthenes - A new process for the manufacture of iodinated xanthenes in high purity includes a cyclization step followed by an iodination step. No extraction, chromatographic or solvent concentration steps are required, and the intermediate as well as final compounds are isolated via filtration or similar means. The process requires a single organic solvent, and the steps are completed at temperatures below 100° C. The exclusion of chloride ions, of chloride free-radicals, hypochlorite ions, or hypochlorous acid as reagents or from reagents that may generate these species in situ in the presence of oxidants, prevents undesirable impurity formation. Several new compounds have been conceived and isolated using these methods. These new compounds are also formed into new medicaments. | 11-20-2014 |