Patent application number | Description | Published |
20100022532 | USE OF A KINASE INHIBITOR FOR THE TREATMENT OF PARTICULAR RESISTANT TUMORS - The invention provides low molecular weight compounds, namely 1H-thieno[2,3-c]pyrazoles, showing a high affinity for the ATP pocket of ABL tyrosine kinase. These compounds are thus ATP-competitive tyrosine kinase inhibitors displaying a significant inhibitory potency also, and in particular, towards BCR-ABL inhibitor-resistant T315I ABL mutants. The compounds of the invention find a useful application in the treatment of BCR-ABL inhibitor-resistant ABL-mediated diseases, such as Imatinib-resistant chronic myelogenous leukemia. Moreover, the invention provides a screening method for the identification of compounds capable of binding the ATP pocket of a kinase protein, in particular of the T315I mutant ABL kinase. | 01-28-2010 |
20100035876 | Use of a Kinase Inhibitor for the Treatment of Particular Resistant Tumors - The invention provides low molecular weight compounds, namely tetrahydropyrrolo[3,4-c]pyrazoles, showing a high affinity for the ATP pocket of ABL tyrosine kinase. These compounds are thus ATP-competitive tyrosine kinase inhibitors displaying a significant inhibitory potency also, and in particular, towards BCR-ABL inhibitor-resistant T315I ABL mutants. The compounds of the invention find a useful application in the treatment of BCR-ABL inhibitor-resistant ABL-mediated diseases, such as Imatinib-resistant chronic myelogenous leukemia. Moreover, the invention provides a screening method for the identification of compounds capable of binding the ATP pocket of a kinase protein, in particular of the T315I mutant ABL kinase. | 02-11-2010 |
Patent application number | Description | Published |
20110254265 | Hydraulic connection assembly with pressure discharge control - The present invention relates to a hydraulic connection assembly for connecting one or more hydraulic lines, of the type comprising a one-block body enclosing one or more hydraulic lines, and at least one draining line connected to said hydraulic lines. | 10-20-2011 |
20120013120 | COMPACT CARTRIDGE COUPLING - The present invention relates to a compact cartridge coupling of the type adapted to connect a pressurized fluid line between a vehicle or apparatus and a user, which coupling is of the type comprising a female semi-coupling adapted to receive a male semi-coupling. | 01-19-2012 |
20120175000 | COMPACT CARTRIDGE COUPLING - The present invention relates to a compact cartridge coupling of the type adapted to connect a pressurized fluid line between a vehicle or apparatus and a user, which coupling is of the type comprising a female semi-coupling adapted to receive a male semi-coupling. | 07-12-2012 |
20120181465 | COMPACT CARTRIDGE COUPLING - The present invention relates to a compact cartridge coupling of the type adapted to connect a pressurized fluid line between a vehicle or apparatus and a utility, which coupling is of the type comprising a female half-coupling adapted to accommodate a male half-coupling. | 07-19-2012 |