Patent application number | Description | Published |
20090263326 | NANO-SCALE CONTRAST AGENTS AND METHODS OF USE - Compositions and methods are disclosed for evaluating a subject's vasculature integrity, for differentiating between a malignant lesion and a benign lesion, for evaluating the accessibility of a tumor to nano-sized therapeutics, for treating tumors, and for live or real time monitoring of a nano-probe's biodistribution. | 10-22-2009 |
20090311191 | IMAGING OF ATHEROSCLEROTIC PLAQUES USING LIPOSOMAL IMAGING AGENTS - Compositions and methods are disclosed for imaging atherosclerotic plaques. Example compositions comprise liposomes, the liposomes comprising: at least one first lipid or phospholipid; at least one second lipid or phospholipid which is derivatized with one or more polymers; and at least one sterically bulky excipient capable of stabilizing the liposomes. The liposomes encapsulate or associate a contrast enhancing agent. | 12-17-2009 |
20100202974 | NANO-SCALE CONTRAST AGENTS AND METHODS OF USE - Compositions and methods are disclosed for evaluating a subject's vasculature integrity, for differentiating between a malignant lesion and a benign lesion, for evaluating the accessibility of a tumor to nano-sized therapeutics, for treating tumors, and for live or real time monitoring of a nano-probe's biodistribution. | 08-12-2010 |
20120231067 | VESICLE COMPOSITIONS - Vesicle compositions are provided that comprise a therapeutic compound. The vesicle compositions may be capable of releasing the therapeutic compound in response to the presence of an external trigger. The vesicle compositions may comprise a plurality of biocompatible vesicles. The biocompatible vesicles may comprise a therapeutic compound for treatment of a patient in need thereof, and one or more cross-linkages between two or more of the biocompatible vesicles, each cross-linkage comprising a chemical sensing moiety and a sensed moiety. In some embodiments, the therapeutic compound may be any compound that provides palliative, curative, or otherwise beneficial effects to a patent. | 09-13-2012 |
20120258044 | LIPID-BASED NANOPARTICLES - Lipid-based nanoparticle compositions are provided. The compositions generally comprise lipid-hydrophilic polymer-amyloid binding ligand conjugates, and may be liposomal compositions. The compositions, including the liposomal compositions, may be useful for imaging and/or the treatment of amyloid-β plaque deposits characteristic of Alzheimer's Disease. | 10-11-2012 |
20130189187 | NANO-SCALE CONTRAST AGENTS AND METHODS OF USE - Compositions and methods are disclosed for evaluating a subject's vasculature integrity, for differentiating between a malignant lesion and a benign lesion, for evaluating the accessibility of a tumor to nano-sized therapeutics, for treating tumors, and for live or real time monitoring of a nano-probe's biodistribution. | 07-25-2013 |
20130190605 | METHODS AND COMPOSITIONS FOR OBJECTIVELY CHARACTERIZING MEDICAL IMAGES - Methods and compositions are provided for objectively characterizing a pathological lesion in a patient. The method comprises: introducing into the patient a contrast enhancing agent; subjecting the patient to at least one of magnetic resonance imaging and computed tomography to obtain an image; and applying a 3-D autocorrelation function to a subdomain of interest of the image to obtain at least one 3-D autocorrelation spectrum. The method may further comprise comparing the at least one 3-D autocorrelation spectrum to a pre-existing 3-D autocorrelation spectrum that is characteristic for the pathological lesion. In one example, the methods and compositions may be useful for identifying and objectively characterizing amyloid plaque deposits characteristic of Alzheimer's Disease. | 07-25-2013 |
Patent application number | Description | Published |
20120017185 | AUTOMATIC OPTIMAL INTEGRATED CIRCUIT GENERATOR FROM ALGORITHMS AND SPECIFICATION - Systems and methods are disclosed to automatically design a custom integrated circuit includes receiving a specification of the custom integrated circuit including computer readable code and one or more constraints on the custom integrated circuit; automatically devising a processor architecture and generating a processor chip specification uniquely customized to the computer readable code which satisfies the constraints; and synthesizing the chip specification into a layout of the custom integrated circuit. | 01-19-2012 |
20120017187 | AUTOMATIC OPTIMAL INTEGRATED CIRCUIT GENERATOR FROM ALGORITHMS AND SPECIFICATION - Systems and methods are disclosed to automatically design a custom integrated circuit based on algorithmic process or code as input and using highly automated tools that requires virtually no human involvement is disclosed. The method includes receiving a specification of the custom integrated circuit including computer readable code and one or more constraints on the custom integrated circuit; automatically generating a computer architecture for the computer readable code that best fits the constraints; automatically determining an instruction execution sequence based on the code profile and reassigning or delaying the instruction sequence to spread operation over one or more processing blocks to reduce hot spots; continuously evaluating and optimizing one or more factors including physical implementation, and local and global area, timing, or power at an architecture level above RTL or gate-level synthesis; automatically generating a software development kit (SDK) and the associated firmware automatically to execute the computer readable code on the custom integrated circuit; automatically generating associated test suites and vectors for the computer readable code on the custom integrated circuit; and automatically synthesizing the designed architecture and generating a computer readable description of the custom integrated circuit for semiconductor fabrication. | 01-19-2012 |
20120017189 | ARCHITECTURAL LEVEL POWER-AWARE OPTIMIZATION AND RISK MITIGATION - Systems and methods are disclosed to automatically synthesize a custom integrated circuit by receiving a specification of the custom integrated circuit including computer readable code and generating a profile of the computer readable code to determine instruction usage; automatically generating a processor architecture uniquely customized to the computer readable code, the processor architecture having one or more processing blocks to implement one or more instructions; determining an instruction execution sequence based on the code profile and reassigning the instruction sequence to spread operation to different blocks on the IC to reduce hot spots; and synthesizing the generated processor chip specification into a computer readable description of the custom integrated circuit for semiconductor fabrication. | 01-19-2012 |
20120017198 | APPLICATION DRIVEN POWER GATING - Systems and methods are disclosed to manage power in a custom integrated circuit (IC) design by receiving a specification of the custom integrated circuit including computer readable code and generating a profile of the computer readable code to determine instruction usage; automatically generating a processor architecture uniquely customized to the computer readable code, the processor architecture having one or more processing blocks and one or more power domains; determining when each processing block is needed based on the code profile and assigning each block to one of the power domains; and gating the power domains with power based on the code profile; and synthesizing the generated architecture into a computer readable description of the custom integrated circuit for semiconductor fabrication. | 01-19-2012 |
20120096417 | INTEGRATED DATA MODEL BASED FRAMEWORK FOR DRIVING DESIGN CONVERGENCE FROM ARCHITECTURE OPTIMIZATION TO PHYSICAL DESIGN CLOSURE - Systems and methods are disclosed to automatically synthesize a custom integrated circuit by receiving a specification of the custom integrated circuit including computer readable code and one or more constraints on the custom integrated circuit; encoding architecture level knowledge in a data model to generate and pass new constraints for physical synthesis of a chip specification uniquely customized to the computer readable code; receiving a look-ahead cost function during architecture optimization consistent with cost observed later in the flow after detailed physical synthesis is performed, wherein the look-ahead cost function is generated from a prior iteration and supplied to a subsequent iteration through the data model; automatically translating information available at one optimization point into a constraint for another optimization point invoked at a different place in the design flow using the data model; and synthesizing a computer readable description of the chip specification into the custom integrated circuit for semiconductor fabrication. | 04-19-2012 |
20120096420 | INTELLIGENT ARCHITECTURE CREATOR - Systems and methods are disclosed to automatically generate a processor architecture for a custom integrated circuit (IC) described by a computer readable code. The IC has one or more timing and hardware constraints. The system extracts parameters defining the processor architecture from a static profile and a dynamic profile of the computer readable code; iteratively optimizes the processor architecture by changing one or more parameters until all timing and hardware constraints expressed as a cost function are met; and synthesizes the generated processor architecture into a computer readable description of the custom integrated circuit for semiconductor fabrication. | 04-19-2012 |
20130104097 | PROGRAMMATIC AUTO-CONVERGENT METHOD FOR "PHYSICAL LAYOUT POWER HOT-SPOT" RISK AWARE ASIP ARCHITECTURE CUSTOMIZATION FOR PERFORMANCE OPTIMIZATION - Systems and methods are disclosed to automatically method to manage power in a custom integrated circuit (IC) design with a code profile by receiving an instruction execution sequence based on the code profile and reassigning or delaying the instruction sequence to spread operations or activities over a plurality of processing blocks to reduce hot spots; applying sub-region weight distributions to estimate power hot-spot locations; and synthesizing the generated architecture into a computer readable description of the custom integrated circuit for semiconductor fabrication. | 04-25-2013 |
20130111426 | PROGRAMMATIC AUTO-CONVERGENT METHOD FOR PHYSICAL DESIGN FLOORPLAN AWARE RE-TARGETABLE TOOL SUITE GENERATION (COMPILER-IN-THE-LOOP) FOR SIMULTANEOUS INSTRUCTION LEVEL (SOFTWARE) POWER OPTIMIZATION AND ARCHITECTURE LEVEL PERFORMANCE OPTIMIZATION FOR ASIP DESIGN | 05-02-2013 |
20130263067 | AUTOMATIC OPTIMAL INTEGRATED CIRCUIT GENERATOR FROM ALGORITHMS AND SPECIFICATION - Systems and methods are disclosed to automatically design a custom integrated circuit by receiving a specification of the custom integrated circuit including computer readable code and one or more constraints on the custom integrated circuit; automatically generating a computer architecture with programmable processor and one or more co-processors for the computer readable code that best fits the constraints; automatically determining an instruction execution sequence based on the code profile and reassigning or delaying the instruction sequence to spread operation over one or more processing blocks to reduce hot spots; automatically generating associated test suites and vectors for the computer readable code on the custom integrated circuit; and automatically synthesizing the designed architecture and generating a computer readable description of the custom integrated circuit for semiconductor fabrication. | 10-03-2013 |
20130346926 | Automatic optimal integrated circuit generator from algorithms and specification - Systems and methods are disclosed to automatically design a custom integrated circuit based on algorithmic process or code as input and using highly automated tools that requires virtually no human involvement is disclosed. | 12-26-2013 |
20140082325 | INTELLIGENT ARCHITECTURE CREATOR - Systems and methods are disclosed to automatically generate a processor architecture for a custom integrated circuit (IC) described by a computer readable code. The IC has one or more timing and hardware constraints. The system extracts parameters defining the processor architecture from a static profile and a dynamic profile of the computer readable code; iteratively optimizes the processor architecture by changing one or more parameters until all timing and hardware constraints expressed as a cost function are met; and synthesizes the generated processor architecture into a computer readable description of the custom integrated circuit for semiconductor fabrication. | 03-20-2014 |
Patent application number | Description | Published |
20090249062 | METHOD AND APPARATUS FOR DISTRIBUTING CERTIFICATE REVOCATION LISTS (CRLs) TO NODES IN AN AD HOC NETWORK - A method and apparatus for distributing Certificate Revocation List (CRL) information in an ad hoc network are provided. Ad hoc nodes in an ad hoc network can each transmit one or more certificate revocation list advertisement message(s) (CRLAM(s)). Each CRLAM includes an issuer certification authority (CA) field that identifies a certification authority (CA) that issued a particular certificate revocation list (CRL), a certificate revocation list (CRL) sequence number field that specifies a number that specifies the version of the particular certificate revocation list (CRL) that was issued by the issuer certification authority (CA). Nodes that receive the CRLAMs can then use the CRL information provided in the CRLAM to determine whether to retrieve the particular certificate revocation list (CRL). | 10-01-2009 |
20100031027 | METHOD AND DEVICE FOR DISTRIBUTING PUBLIC KEY INFRASTRUCTURE (PKI) CERTIFICATE PATH DATA - A method and device for distributing public key infrastructure (PKI) certificate path data enables relying nodes to efficiently authenticate other nodes in an autonomous ad-hoc network. The method includes compiling, at a certificate path management unit (CPMU), the PKI certificate path data (step | 02-04-2010 |
20100070755 | METHOD AND DEVICE FOR CONFIRMING AUTHENTICITY OF A PUBLIC KEY INFRASTRUCTURE (PKI) TRANSACTION EVENT - A method and device for confirming authenticity of a public key infrastructure (PKI) transaction event between a relying node and a subject node in a communication network enables improved network security. According to some embodiments, the method includes establishing at a PKI event logging (PEL) server a process to achieve secure communications with the relying node (step | 03-18-2010 |
20110154024 | METHOD AND APPARATUS FOR SELECTING A CERTIFICATE AUTHORITY - A certificate authority selection unit implements a method for selecting one of a plurality of certificate authorities servicing a plurality of administrative domains in a communication system. The method includes: receiving, from an end-entity via an interface, a certificate service request associated with an identifier; selecting, based on the identifier, one of the plurality of administrative domains in the communication system, wherein the plurality of administrative domains are serviced by a plurality of certificate authorities; retrieving a security profile for the end-entity; and selecting, based on the security profile for the end-entity, one of the plurality of certificate authorities to process the certificate service request. | 06-23-2011 |
20140068251 | METHOD AND DEVICE FOR DYNAMICALLY UPDATING AND MAINTAINING CERTIFICATE PATH DATA ACROSS REMOTE TRUST DOMAINS - A method and device is provided for dynamically maintaining and updating public key infrastructure (PKI) certificate path data across remote trusted domains to enable relying parties to efficiently authenticate other nodes in an autonomous ad-hoc network. A certificate path management unit (CPMU) monitors a list of sources for an occurrence of a life cycle event capable of altering an existing PKI certificate path data. Upon determining that the life cycle event has occurred, the CPMU calculates a new PKI certificate path data to account for the occurrence of the life cycle event and provides the new PKI certificate path data to at least one of a relying party in a local domain or a remote CPMU in a remote domain. | 03-06-2014 |
Patent application number | Description | Published |
20080293435 | Method and apparatus to select an optimum site and/or sector to provide geo-location data - A system and method selects secondary base stations to task that provide geo-location information used to geo-locate a mobile station. A network overlay location system may be co-located at base station sites of a wireless communications network. The location measurement units of the network overlay system provide location information of the mobile station, which may be determined via one or more geo-location techniques, for example: time of arrival (TOA), time difference of arrival (TDOA), uplink time difference of arrival (UTDOA), angle of arrival (AOA), signal power, radio fingerprinting etc. Selecting secondary base stations to task using various selection criteria may provide optimum results when geo-locating a mobile station. | 11-27-2008 |
20110092226 | Method and Apparatus to Select an Optimum Site and/or Sector to Provide Geo-Location Data - A system and method selects secondary base stations to task that provide geo-location information used to geo-locate a mobile station. A network overlay location system may be co-located at base station sites of a wireless communications network. The location measurement units of the network overlay system provide location information of the mobile station, which may be determined via one or more geo-location techniques, for example: time of arrival (TOA), time difference of arrival (TDOA), uplink time difference of arrival (UTDOA), angle of arrival (AOA), signal power, radio fingerprinting etc. Selecting secondary base stations to task using various selection criteria may provide optimum results when geo-locating a mobile station. | 04-21-2011 |
Patent application number | Description | Published |
20080207523 | COMPOUNDS AS APTAMER-DIMERS AND THEIR USES IN DIAGNOSIS AND THERAPY - The object of the present invention is solved by compositions of peptide linkers and their use for synthesis and annealing of aptamer oligonucleotides in form of dimers. The present invention in particularly provides said compositions for the use as a diagnostic and/or therapeutic agent. | 08-28-2008 |
20080292548 | COMPOUNDS AND METHODS FOR 18F LABELED AGENTS - The present invention relates to novel compounds suitable for or already radiolabeled with | 11-27-2008 |
20090022664 | Radiolabelling via fluorination of aziridines - The present invention relates to novel compounds suitable for or already radiolabelled with | 01-22-2009 |
20090035215 | RADIOFLUORINATION - The present invention relates to novel compounds suitable for or already radiolabeled with | 02-05-2009 |
20090317326 | RADIOFLUORINATION METHODS - The present invention relates to radiolabelled substitute benzene compounds for diagnostic imaging. The present invention provides methods for preparation of such compounds, in particular, preparation of novel compounds which serve as precursors for | 12-24-2009 |
20110112293 | Purification Strategy for Direct Nucleophilic Procedures - The present invention provides novel and advantageous processes for preparing and purifying chemical compounds such as pharmaceuticals. The processes comprise a nucleophilic substitution reaction with a moiety X wherein the leaving group L of a substrate S in the reaction is covalently attached to a purification moiety M. This concept offers a convenient and lime-saving way to purity the desired product S-X from non-reacted precursors S-L-M and by-products L-M. | 05-12-2011 |
20110137063 | COMPOUNDS AND PROCESSES FOR PRODUCTION OF RADIOPHARMACEUTICALS - The present invention relates to novel perfluorinated precursors for the production of F-18 labeled radiotracers for Positron Emission Tomography (PET) and processes for radiolabeling and purification using these precursors. The invention also comprises radiopharmaceutical kits using these precursors and processes. | 06-09-2011 |