Gray, MA
Alan Gray, North Reading, MA US
Patent application number | Description | Published |
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20140065117 | METHODS FOR PRODUCING AND USING REJUVENATED RED BLOOD CELLS - Methods for treating blood. The methods comprise obtaining whole blood from a donor, mixing the whole blood with a red blood cell enhancement composition, and incubating the mixture of whole blood and red blood cell enhancement composition. The method can be performed at a time proximate to the time of obtaining blood from the donor, or after the blood has been stored for a period of time. The method rejuvenates red blood cells. | 03-06-2014 |
20140212397 | METHODS FOR REJUVENATING RED BLOOD CELLS - Methods for transfusing blood to a mammalian subject. The method includes obtaining a unit of blood, rejuvenating the blood with an enhancement composition, measuring 2,3-DPG concentration of the blood, and delivering the blood to a subject. | 07-31-2014 |
20140212400 | METHODS FOR REJUVINATING RED BLOOD CELLS - Methods and a system for transfusing blood to a mammalian subject. The method includes obtaining a volume of donated red blood cells (RBCs), adding an enhancement composition to the RBCs to form a treated blood composition, incubating the treated blood composition to form an incubated blood composition, and administering the incubated blood composition to a patient. The system includes a functionally-closed, sterile Y-type tube set. | 07-31-2014 |
20140221958 | FUNCTIONALLY-CLOSED, STERILE BLOOD PROCESSING SOLUTION SYSTEM AND METHOD - Delivering a blood processing solution to blood in a blood bag includes coupling a first tube to a vented spike at one end and to a Y-shaped tube connector at a second end. An in-line microbiotic barrier filter is coupled to the first tube between its ends. A second tube is coupled to a transfer bag at one end and to the Y-shaped tube connector at its other end. A third tube is coupled to the output of the Y-shaped tube connector and sealed at its distal end. The blood bag includes a fourth tube that is sealed at a distal end. The third tube is welded to the fourth tube using a sterile tubing welder, wherein a functionally-closed, sterile flow path through which the blood processing solution can flow into the blood bag is maintained. | 08-07-2014 |
Benjamin N. Gray, Somerville, MA US
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20110265226 | IMPROVED PRODUCTION OF PROTEINS WITH DOWNSTREAM BOX FUSIONS IN PLASTIDS AND IN BACTERIA - The present invention is directed to the use of certain selected downstream box (“DB”) regions and codon-optimized DB regions to achieve high-level protein expression in transformed organisms or organelles. In particular, high level protein expression in plastids and bacteria can be achieved by fusion of the TetC or NPTII DB region to a gene of interest. Protein expression in a transformed organism or organelle can also be enhanced by optimization of codon usage within the DB region based on codons preferentially found in the DB regions of highly expressed native genes in the organism or organelle. Methods for enhanced protein expression, and related nucleic acid molecules, expression vectors, transformed cells, and transgenic organisms, are provided. The present invention is particularly useful for expressing cellulolytic enzymes, including a suite of several cellulolytic enzymes, in plastids, bacteria and algae. | 10-27-2011 |
Brian Lawrence Gray, Chestnut Hill, MA US
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20100292486 | RECYCLABLE METATHESIS CATALYSTS - Highly active, recoverable and recyclable transition metal-based metathesis catalysts and their organometallic complexes including dendrimeric complexes are disclosed, including a Ru complex bearing a 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene and styrenyl ether ligand. The heterocyclic ligand significantly enhances the catalytic activity, and the styrenyl ether allows for the easy recovery of the Ru complex. Derivatized catalysts capable of being immobilized on substrate surfaces are also disclosed. The present catalysts can be used to catalyze ring-closing metathesis (RCM), ring-opening (ROM) and cross metatheses (CM) reactions, and promote the efficient formation of various trisubstituted olefins at ambient temperature in high yield. | 11-18-2010 |
Christopher R. Gray, Ashfield, MA US
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20120302930 | TRACTION BED - A traction bed includes a frame upon which an individual is supportable, first and second lever arms pivotably coupled to the frame at a location proximate a first end of the frame and configured to be coupled to the individual's upper torso, third and fourth lever arms pivotably coupled to the frame at a location proximate a second end of the frame and configured to be coupled to the individual's pelvis or pelvic region, and a control system operable to direct a force onto each of the lever arms to pivot the lever arms relative to the frame. The force directed to the first and third lever arms is separately variable from the force directed to the second and fourth lever arms to provide differential traction on the individual's body. | 11-29-2012 |
20130226060 | Traction Bed - A traction bed includes (a) a frame upon which an individual is supportable, (b) a first single-sided lever arm pivotably coupled to the frame at a location proximate both a first end of the frame and a first side of the frame, wherein the first single-sided lever arm is configured to be coupled to an arm of an individual, (c) a second single-sided lever arm pivotably coupled to the frame at a location proximate both a second end of the frame and the first side of the frame, wherein the second single-sided lever arm is configured to be coupled to a leg of an individual, and (d) a control system operable to direct a force onto each of the single-sided lever arms to pivot the single-sided lever arms relative to the frame, wherein the force directed to the first single-sided lever arm is separately variable from the force directed to the second single-sided lever arm. | 08-29-2013 |
Darren Gray, Brookline, MA US
Patent application number | Description | Published |
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20080220422 | RARE CELL ANALYSIS USING SAMPLE SPLITTING AND DNA TAGS - The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample. | 09-11-2008 |
20100136529 | Rare cell analysis using sample splitting and DNA tags - The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample. | 06-03-2010 |
20120171666 | Rare Cell Analysis Using Sample Splitting And DNA Tags - The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample. | 07-05-2012 |
20120171667 | Rare Cell Analysis Using Sample Splitting And DNA Tags - The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample. | 07-05-2012 |
David Lawrence Firman Gray, Groton, MA US
Patent application number | Description | Published |
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20140128374 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS - The present invention provides, in part, compounds of Formula I: | 05-08-2014 |
20140336176 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS - The present invention provides, in part, compounds of Formula I: | 11-13-2014 |
Don Gray, Needham, MA US
Patent application number | Description | Published |
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20100250274 | MATHEMATICAL INDEX BASED HEALTH MANAGEMENT SYSTEM - A process for health management of participants includes gathering data on health attributes of the participants. The Kanri index value for each of the participants is then calculated by performing Gram-Schmidt orthogonalization and Mahalanobis distance for each of the participants from a mean of the Gram-Schmidt variables. The participant is then provided with a high impact prescription from the health attributes to improve participant health. | 09-30-2010 |
20130073594 | Methods and Systems for Assessing Data Quality - Methods and systems for assessing data involve, collecting samples of data elements from a database storing a population of data elements representing attributes of each numerous different financial transactions. Critical data elements from the collected samples are determined. Data quality rules are built and data dimensions are calculated for the critical data elements. A quality of data within the critical data elements for different data quality dimensions is monitored. Critical data elements that produce a high number of outliers are identified and causes for the outliers are identified. Thereafter, a corrective action plan to address a solution for the causes for the outliers may be developed and executed. | 03-21-2013 |
Eric S. Gray, Westford, MA US
Patent application number | Description | Published |
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20080197937 | High Directivity Ultra-Compact Coupler - A coupler includes a substrate and a stack of first and second dielectric layers extending over a top surface of the substrate. The first dielectric layer comprises different dielectric material than the second dielectric layer. Two conductive lines extend over the stack of first and second dielectric layers, and are formed in the same plane parallel to a surface of the substrate. | 08-21-2008 |
20080197938 | SYSTEM INCLUDING A HIGH DIRECTIVITY ULTRA-COMPACT COUPLER - A system with an RFin terminal and an RFout terminal includes an output matching network. The system further includes a coupler having a thru arm connected between the output matching network and the RFout terminal, and a coupled arm connected to a detector circuit. The coupler further includes a stack of first and second dielectric materials having different dielectric constants. The stack of first and second dielectric materials extends over a top surface of a substrate. The thru arm and the coupled arm extend over the stack of first and second dielectric materials in the same plane parallel to a surface of the substrate. | 08-21-2008 |
Gary S. Gray, Brookline, MA US
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20090155836 | METHODS FOR TREATING HIV INFECTED SUBJECTS - Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis. | 06-18-2009 |
Gavin Gray, Cambridge, MA US
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20140324220 | REMOTE TESTING METHOD AND SYSTEM - In one example, a method is provided for a computing device to facilitate testing of an electronic apparatus. The method includes receiving a request from an apparatus coupled to a network to which the computing device is also coupled. The method further includes retrieving a command for a robot controlled by the computing device from the request, and configuring the robot to physically interface with the electronic apparatus to perform one or more tests according to the command. | 10-30-2014 |
George W. Gray, North Andover, MA US
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20100121873 | METHOD AND SYSTEM FOR DETERMINING CORRELATION BETWEEN CLINICAL EVENTS - The present application relates to improving healthcare practices in clinical facilities. In a facility that utilizes electronic patient charts ( | 05-13-2010 |
20140221959 | AUTOMATED PROGRAMMING OF INFUSION THERAPY - An infusion management system includes an infusion management server configured for providing an order to an infusion device to administer an infusion and the infusion device. The infusion device may be configured for receiving the order, associating the order with a patient, and adjusting at least one setting according to the order. A method for administering an infusion, an interface for an infusion device and a computer program product are also disclosed. | 08-07-2014 |
20140222450 | MEDICAL DEVICE MANAGEMENT USING ASSOCIATIONS - Via communications with an association management resource, an operator of a respective fluid delivery system can associate a medical device (fluid pump) with a particular entity such as a patient, location, one or more other medical devices, the caregiver, etc. Thereafter, the operator of the fluid delivery system is able to better manage use of the fluid delivery system based on relevant medical information, which is accessible as a result of creating the association. For example, the association management resource gathers and stores information associated with the entity prior to the operator providing the input associating the fluid delivery system with the entity. After the operator of the fluid delivery system creates the association, the medical information associated with the entity is immediately available to the fluid delivery system and/or corresponding operator of the fluid delivery system. | 08-07-2014 |
20150088094 | MEDICAL DEVICE MANAGEMENT USING SAFETY SUPERVISOR - A fluid flow manager executing on first hardware controls a flow of fluid outputted from a fluid delivery pump to a recipient. A monitor resource, executing on second hardware operating independently of the first hardware, monitors for an occurrence of a failure condition associated with the delivery of fluid. In response to detecting occurrence of a failure condition associated with delivery of the fluid, the monitor resource generates a control output. The control output can be used to perform operations such as discontinue delivery of the fluid, notify a respective caregiver of the delivery failure, etc. | 03-26-2015 |
Jack Conrad Gray, Cambridge, MA US
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20130085718 | Generating An Analytical Energy Model - Methods, systems, and apparatus, including computer programs encoded on a system, for generating an analytical energy model from a conceptual representation or a mass form model. In one aspect, actions include receiving a conceptual representation of a building including one or more user-defined floor levels and multiple surfaces defining volumetric space, and, responsive to a request to generate an analytical energy model, automatically generating the analytical energy model by: deriving geometric information from the conceptual representation; defining one or more mass volumes; algorithmically assigning one or more surface types to mass volume surfaces; defining one or more thermal mass zones based on the mass volumes and a corresponding number of user-defined floor levels; deriving thermal properties of the one or more thermal mass zones; and combining the defined one or more thermal mass zones, the derived thermal properties, and predefined analytical energy model parameters to generate the analytical energy model. | 04-04-2013 |
Jeff Gray, Lexington, MA US
Patent application number | Description | Published |
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20090227964 | Implantable Fluid Transfer Access Port - An implantable port comprises a port body forming a fluid reservoir and a septum sealing a proximal end of the reservoir in combination with a clicker member biased toward a first configuration, the clicker member being deformable via mechanical force applied thereto and configured so that, when subject to a force of at least a predetermined magnitude, the clicker member rapidly deforms away from the first configuration to a second configuration to provide one of an aural and tactile feedback to the user. | 09-10-2009 |
20100063451 | Power Injectable Port Identification - An implantable port for accessing internal body structures, the port comprises a proximal housing including an opening providing access to an interior of the port and a distal housing adapted for assembly with the proximal housing, the distal housing including a reservoir which, when the distal housing is mated with the proximal housing is in fluid communication with the opening of the proximal housing in combination with a radiopaque element in one of the proximal and distal housings, a shape of the radiopaque element identifying, when imaged, a structural characteristic of the port not otherwise identifiable visually. | 03-11-2010 |
20100076302 | Invisible Power Port ID Tattoo - A solution for use in medical procedures, comprises including a plurality of microspheres holding a fluorescent dye reactive to ultraviolet light and a base dye which, under white light, has one of a color substantially matching a color of a target portion of skin into which it is to be injected and which has, under UV light, a color slightly darker than a color of the target portion of skin. A method comprises identifying a target area of the skin to be accessed in a medical procedure and injecting into at least a portion of the target area a solution including a plurality of microspheres holding a colored dye and a fluorescent dye reactive to ultraviolet light in combination with locating the target area by illuminating the skin with ultraviolet light. | 03-25-2010 |
20100191192 | Three-way Valve for Power Injection in Vascular Access Devices - An apparatus for facilitating fluid flow between an internal body structure and a device external to the body comprises a housing having proximal and distal chambers separated from one another by a wall and fluidly connected to proximal port and distal ports. The wall includes a valve selectively sealing first and second openings thereof and a canopy biased toward a sealing position sealingly surrounding the first opening. The bias of the canopy is set to define a first pressure differential at which the canopy is moved out of the sealing position to permit fluid transfer therepast in a first direction. A duck-bill stem extends through the second opening and includes a lumen extending therethrough with walls of the stem being biased toward a sealing position and configured so that, when a second pressure differential is applied at at least a second level, the first end opens to permit flow therepast. | 07-29-2010 |
20120059250 | Power Injectable Port Identification - An implantable port for accessing internal body structures, the port comprises a proximal housing including an opening providing access to an interior of the port and a distal housing adapted for assembly with the proximal housing, the distal housing including a reservoir which, when the distal housing is mated with the proximal housing is in fluid communication with the opening of the proximal housing in combination with a radiopaque element in one of the proximal and distal housings, a shape of the radiopaque element identifying, when imaged, a structural characteristic of the port not otherwise identifiable visually. | 03-08-2012 |
Jeff Gray, Sudbury, MA US
Patent application number | Description | Published |
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20130103004 | LOCKING CATHETER HUB - A drainage catheter, comprising an elongate body member, an elongate flexible member and a hub, the hub including a base and a collar, the base an internal passageway and a side lumen and an outer surface including an engagement element and a mating surface portion, and the collar including a side lumen extending from the inner surface to the outer surface and wherein the inner surface of the collar includes a mating surface portion and a counter element, wherein the elongate flexible member extends through the side lumen side lumens, and wherein the hub has an unlocked position where the engagement element and the counter element are not engaged and a locked position where the engagement element and the counter element are engaged, the collar is tightened on the base and the elongate flexible element is clamped between the mating surface portions of the base and the collar. | 04-25-2013 |
20140114227 | LYMPHEDEMA MEDICAL DEVICE - Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a medical device for moving lymphatic fluid. The medical device may include an implantable body having an inlet end region and an outlet end region. The inlet end region may include one or more inlet opening. The outlet end region may include one or more outlet openings. A pump member may be positioned between the inlet end region and the outlet end region. The pump member may be configured to draw lymphatic fluid into the implantable body through the inlet end region and transfer lymphatic fluid out from the implantable body through the outlet end region. | 04-24-2014 |
20140275908 | CHEMOCHROMIC MEDICAL ARTICLES - The present invention is directed to medical articles which exhibit a color change upon exposure to an analyte of interest and to methods of detecting analytes in bodily fluid using the same. | 09-18-2014 |
Jeffrey Gray, Sudbury, MA US
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20140276655 | DRAINAGE CATHETER WITH CUTTING TOOL - Medical devices and methods for making and using the same are disclosed. An example medical device may include a drainage catheter. The drainage catheter may include an elongate catheter shaft having a lumen formed therein and a distal region proximal end. The distal region may have a plurality of openings formed therein. The openings may be in fluid communication with the lumen. The distal region may be configured to shift between a first configuration and a looped configuration. The catheter may also include an actuation member for shifting the distal region between the first configuration and the looped configuration. A cutting member may be disposed adjacent to the proximal end of the catheter shaft. The cutting member may be adapted to cut a portion of the actuation member. | 09-18-2014 |
Jesse V. Gray, Somerville, MA US
Patent application number | Description | Published |
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20140250592 | INFANT CALMING/SLEEP-AID DEVICE AND METHOD OF USE - An infant calming/sleep-aid device includes a main moving platform that moves in a reciprocating manner and an actuator that drives the reciprocating movement of the main moving platform. The moving head platform is linked to the main moving platform and at least one of a motion sensing device and a sound sensing device are either at or proximate to a moving head platform that is pivotally linked to the main moving platform. A logic circuit links at least one of the motion and sound sensing devices of the infant calming/sleep aid-device to the main moving platform whereby signals detected modulate movement of the main moving platform. A sound generating device is linked to the logic circuit. | 09-11-2014 |
20150045608 | INFANT CALMING/SLEEP-AID, SIDS PREVENTION DEVICE, AND METHOD OF USE - An infant calming/sleep-aid/SIDS detection device is provided that includes a main moving platform that moves in a variable manner with accompanying variable sound generation, the sound and motion adapted to calm a fussy baby, induce sleep, and maintain sleep under normal conditions. The device may also have a sensor for detection of pauses in breathing and/or detection of resultant biological changes related to breathing pauses and respond with appropriate stimuli to arouse the baby and allow breathing to recommence. | 02-12-2015 |
John R. Gray, Foxborough, MA US
Patent application number | Description | Published |
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20090216269 | MULTICOMPONENT FUSED SUTURE LOOP AND APPARATUS FOR MAKING SAME - A fused loop of an elongated material, such as a surgical suture, and apparatus for making the loop are described. Portions of one or more segments of elongated material may be fused in an ultrasonic welding process to form a welded joint. Multiple materials each with different a different melting point may be used for one or more fibers within the elongated material. The elongated material may include a sheath, which may be used to protect a core within the elongated material. A fused region of the fused loop may be formed when a material with a lower melting temperature, compared to one or more other materials in the elongated material, is caused to melt. A related ultrasonic welding apparatus may include a temperature sensor for control of the welding process. | 08-27-2009 |
20130012963 | MULTICOMPONENT FUSED SUTURE LOOP AND APPARATUS FOR MAKING SAME - A fused loop of an elongated material, such as a surgical suture, and apparatus for making the loop are described. Portions of one or more segments of elongated material may he fused in an ultrasonic welding process to form a welded joint. Multiple materials each with a different melting point may be used for one or more fibers within the elongated material The elongated material may include a sheath, which may be used to protect a core within the elongated material. A fused region of the fused loop may be formed when a material with a lower melting temperature, compared to one or more other materials in the elongated material, is caused to melt. A related ultrasonic welding apparatus may include a temperature sensor for control of the welding process. | 01-10-2013 |
Keith J. Gray, Gardner, MA US
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20120080512 | Sustainable coated corrugated fiberboard container - A packaging container having sustainable repulpable/recyclable capability specifically sized to maintain the integrity of the Meal, Ready-to-Eat (MRE™) rations used by the U.S. Army and military services. A coated corrugated fiberboard using a C-flute configuration is utilized in a novel packaging design that incorporates a liner or a vertical container divider. | 04-05-2012 |
20130292379 | SUSTAINABLE COATED CORRUGATED FIBERBOARD CONTAINER - A packaging container having sustainable repulpable/recyclable capability specifically sized to maintain the integrity of the Meal, Ready-to-Eat (MRE) rations used by the U.S. Army and military services. A coated corrugated fiberboard using a C-flute configuration is utilized in a novel packaging design that incorporates a liner or a vertical container divider. | 11-07-2013 |
Kevin Gray, Northborough, MA US
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20110269201 | REDIRECTED BIOENERGETICS IN RECOMBINANT CELLULOLYTIC CLOSTRIDIUM MICROORGANISMS - Compositions and methods are provided for redirecting metabolic solventogenesis pathways to enhance the product yield from fermentation of biomass. | 11-03-2011 |
Mark R. Gray, West Roxbury, MA US
Patent application number | Description | Published |
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20080207489 | Use of CCN5 for treatment of smooth muscle proliferation disorders - The invention provides methods for treating a smooth muscle cell disorder such as asthma, vascular injury, persistent pulmonary hypertension in the newborn, pulmonary hypertension in adults, megaureter, pyloric stenosis, uterine fibroids, lymphangioleiomyomatosis (LAM), cervical incompetence, or cancer, and methods for assessing smooth muscle tissue remodeling in a mammal by expressing CCN5 in a smooth muscle cell of the mammal, or by contacting the tissue directly with CCN5. | 08-28-2008 |
Matthew Gray, Reading, MA US
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20130179762 | Method and Apparatus for Animating Transitions Between Search Results - The technology described relates to animated transitions between consecutive sets of search engine results. | 07-11-2013 |
Matthew K. Gray, Somerville, MA US
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20090293106 | METHOD AND APPARATUS FOR CONTROLLING WIRELESS NETWORK ACCESS PRIVILEGES BASED ON WIRELESS CLIENT LOCATION - An access point through which a wireless device attaches to a wireless network determines the access privileges that will be accorded to the device based on a criteria set, such as the ID and physical location of the device requesting network access, the access point through which the device is connected to the network and user credentials. The location of the device is determined by a location determination system using the signal strength of the device signal. The location information and ID information is provided to an access server that uses the criteria set to retrieve access privileges from a privilege database. The retrieved access privileges are then applied to the wireless device by means of the access point and other devices in the wireless network. | 11-26-2009 |
Matthew K. Gray, Reading, MA US
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20120101982 | Rich Results Relevant to User Search Queries for Books - Methods, systems, and apparatus, including computer programs encoded on computer storage media, for triggering rich results in response to publication queries. In one aspect, a method includes receiving a publication query. One or more publication search results are obtained. A rich result is triggered based on a score of the first-ranked publication result if it meets a threshold relative to other publication search results. The rich result is populated with additional metadata about the publication obtained from web resources and product resources from multiple corpora. The rich result is provided with the publication search results. | 04-26-2012 |
20120290566 | DYNAMIC IMAGE DISPLAY AREA AND IMAGE DISPLAY WITHIN WEB SEARCH RESULTS - Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for providing image search results with web corpus search results. In one aspect, a method includes determining dimensions of an image display environment in which image search results are to be displayed, determining an insertion score that defines an ordinal insertion position at which the image display environment is to be inserted into a ranking of general search results that defines ordinal positions for each of the general search results, the dimensions and the insertion score determined, in part, from the quality scores of the images, generating a search results resource for displaying the general search results according to their respective ordinal positions and the image display environment at the ordinal insertion position on a client device, and providing the search results resource in response to the search query. | 11-15-2012 |
20130006971 | Dynamic Image Display Area And Image Display Within Web Search Results - Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for providing image search results with web corpus search results. In one aspect, a method includes determining dimensions of an image display environment in which image search results are to be displayed, determining an insertion score that defines an ordinal insertion position at which the image display environment is to be inserted into a ranking of general search results that defines ordinal positions for each of the general search results, the dimensions and the insertion score determined, in part, from the quality scores of the images, generating a search results resource for displaying the general search results according to their respective ordinal positions and the image display environment at the ordinal insertion position on a client device, and providing the search results resource in response to the search query. | 01-03-2013 |
20130156347 | Dynamic Image Display Area And Image Display Within Web Search Results - Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for providing image search results with web corpus search results. In one aspect, a method includes determining dimensions of an image display environment in which image search results are to be displayed, determining an insertion score that defines an ordinal insertion position at which the image display environment is to be inserted into a ranking of general search results that defines ordinal positions for each of the general search results, the dimensions and the insertion score determined, in part, from the quality scores of the images, generating a search results resource for displaying the general search results according to their respective ordinal positions and the image display environment at the ordinal insertion position on a client device, and providing the search results resource in response to the search query. | 06-20-2013 |
20130232134 | Presenting Structured Book Search Results - Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for presenting book search results. A query is received requesting a search of text of a book resource. A presentation of search results that satisfy the query is generated, wherein each of the search results identifies a portion of the book resource, the presentation comprising one or more section headings each corresponding to a respective section of the book resource in which a portion identified by at least one search result occurs, and, search results associated with the corresponding section, each search result associated with a location within the corresponding section, each search result including a snippet of text from the book resource that includes one or more terms of the query, and wherein each search result includes a link to an image of a scanned page of the book in which the snippet of text occurs. | 09-05-2013 |
20140129554 | RICH RESULTS RELEVANT TO USER SEARCH QUERIES FOR BOOKS - Methods, systems, and apparatus, including computer programs encoded on computer storage media, for triggering rich results in response to publication queries. In one aspect, a method includes receiving a publication query. One or more publication search results are obtained. A rich result is triggered based on a score of the first-ranked publication result if it meets a threshold relative to other publication search results. The rich result is populated with additional metadata about the publication obtained from web resources and product resources from multiple corpora. The rich result is provided with the publication search results. | 05-08-2014 |
Nathanael Gray, Boston, MA US
Patent application number | Description | Published |
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20080255112 | Pyrimidine-Substituted Benzimidazole Derivatives as Protein Kinase Inhibitors - The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of Alk, Abl, BRK, Blk, BMX, CSK, c-Src, c-Raf, EGFR, Fes, FGFR3, Fms, Fyn, IGF-IR, IR, IKKα, IKKβ, JAK2, JAK3, KDR, Lck, Met, p70S6k, Ros, Rsk1, SAPK2α, SAPK2β, SAPK3, SIK, Tie2, TrkB and/or WNK3 kinases. | 10-16-2008 |
20110288091 | SOLUBLE MTOR COMPLEXES AND MODULATORS THEREOF - The present invention relates to small molecule modulators of mTORC1 and mTORC2, syntheses thereof, and intermediates thereto. Such small molecule modulators are useful in the treatment of proliferative diseases (e.g., benign neoplasms, cancers, inflammatory diseases, autoimmune diseases, diabetic retinopathy) and metabolic diseases. Novel small molecules are provided that inhibit one or more of mTORC1, mTORC2, and PI3K-related proteins. Novel methods of providing soluble mTORC1 and mTORC2 complexes are discussed, as well as methods of using the soluble complexes in a high-throughput manner to screen for inhibitory compounds. | 11-24-2011 |
20120088766 | FUSED HETEROCYCLIC COMPOUNDS AND THEIR USES - The present application relates to therapeutic organic compounds, compositions comprising an effective amount of a therapeutic organic compound; and methods for treating and preventing disease comprising administering and effective amount of a therapeutic organic compound to a subject in need thereof. | 04-12-2012 |
20130072485 | SOLUBLE MTOR COMPLEXES AND MODULATORS THEREOF - The present invention relates to small molecule modulators of mTORC1 and mTORC2, syntheses thereof, and intermediates thereto. Such small molecule modulators are useful in the treatment of proliferative diseases (e.g., benign neoplasms, cancers, inflammatory diseases, autoimmune diseases, diabetic retinopathy) and metabolic diseases. Novel small molecules are provided that inhibit one or more of mTORC1, mTORC2, and PI3K-related proteins. Novel methods of providing soluble mTORC1 and mTORC2 complexes are discussed, as well as methods of using the soluble complexes in a high-throughput manner to screen for inhibitory compounds. | 03-21-2013 |
20130184287 | INDAZOLE COMPOUNDS AND THEIR USES - The present application relates to therapeutic organic compounds, compositions comprising an effective amount of a therapeutic organic compound; and methods for treating and preventing disease comprising administering and effective amount of a therapeutic organic compound to a subject in need thereof. | 07-18-2013 |
20140309249 | INHIBITORS OF C-JUN-N-TERMINAL KINASE (JNK) - The present invention provides novel compounds according to Formula (I): where Ring A, Ring B, X, L | 10-16-2014 |
20150045370 | SIK INHIBITOR FOR USE IN A METHOD OF TREATING AN INFLAMMATORY AND/OR IMMUNE DISORDER - The present invention relates to the discovery that salt inducible kinases (SIKs) suppress the formation of anti-inflammatory molecules such as IL-10, which are important for the resolution of inflammation and identifies SIK inhibitors that may be used to treat disorders associated with undesirable inflammation, such as inflammatory bowel disease and/or autoimmune disorders. | 02-12-2015 |
Nathanael Schiander Gray, Boston, MA US
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20080221098 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS - The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, Bmx, c-Raf, Csk, Fes, FGFR, Flt3, Ikk, IR, JNK, Lck, Mkk, PKC, PKD, Rsk, SAPK, Syk, Trk, BTK, Src, EGFR, IGF, Mek, Ros and Tie2 kinases. | 09-11-2008 |
20090118273 | Compounds and Compositions as Protein Kinase Inhibitors - The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of Abl, Bcr-Abl, Bmx, BTK, b-RAF, c RAF, CSK, cSRC, Fes, FGFR3, Flt3, IKKα, IKKβ, JNK1α1, JNK2α2, Lck, Met, MKK4, MKK6, p70S6K, PAK2, PDGFRα, PKA, PKCα, PKD2, ROCK-II, Ros, Rsk1, SAPK2α, SAPK2β, SAPK3, SAPK4, SGK, Syk, Tie2 and TrkB kinases. | 05-07-2009 |
20090131400 | IMMUNOSUPPRESSANT COMPOUNDS AND COMPOSITIONS - The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction. | 05-21-2009 |
20090137804 | Compounds and Compositions as Protein Kinase Inhibitors - The invention relates to compounds of formula (I) | 05-28-2009 |
20110098280 | 2,4-PYRIMIDINEDIAMINES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY AND IMMUNE SYSTEM DISORDERS - Novel pyrimidine derivatives of formula I | 04-28-2011 |
20130012476 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS - The invention relates to compounds of formula (I) | 01-10-2013 |
20130012704 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS - The invention relates to compounds of formula (I) | 01-10-2013 |
Nathanael Schiander Gray, Cambridge, MA US
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20110053932 | Protein Kinase Inhibitors and Methods for Using Thereof - The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, and methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of Alk, Abl, Aurora-A, B-Raf, C-Raf, Bcr-Abl, BRK, Blk, Bmx, BTK, C-Kit, C-Raf, C-Src, EphB1, EphB2, EphB4, FGFR1, FGFR2, FGFR3, FLT1, Fms, Flt3, Fyn, FRK3, JAK2, KDR, Lck, Lyn, PDGFRα, PDGFRβ, PKCα, p38, Src, SIK, Syk, Tie2 and TrkB kinases. | 03-03-2011 |
Paul J. Gray, Cambridge, MA US
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20120284622 | CONTEXT-SENSITIVE MOBILE CONTROLLER FOR MEDIA EDITING SYSTEMS - Methods and systems for providing media editing capability to a user of a mobile device in communication with a video or an audio media editing system. The methods involve receiving at the mobile device information specifying a current user context of the media editing system and automatically activating functionality on the mobile device that corresponds to the current editing context. The functionality may be a subset of the editing system controls, controls associated with a plug-in software module, or new controls or control modalities enabled by the form factor and input modes featured on the mobile device. The functionality of the mobile device may be updated as the editing context changes, or temporarily frozen to enable multi-user work flows, with each user using a different editing function. | 11-08-2012 |
20130007043 | VOICE DESCRIPTION OF TIME-BASED MEDIA FOR INDEXING AND SEARCHING - Methods and systems for time-synchronous voice annotation of video and audio media enable effective searching of time-based media content. A user record one or more types voice annotation onto corresponding named voice annotation tracks, which are stored within a media object comprising the time-based media and the annotations. The one or more annotation tracks can then be selectively searched for content using speech or text search terms. Various workflows enable voice annotation to be performed using media editing systems, or one or more stand alone voice annotations systems that permit multiple annotators to operate in parallel, generating different kinds of annotations, and returning their annotation tracks to a central location for consolidation. | 01-03-2013 |
Robert L. Gray, Weston, MA US
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20150075296 | Load Cell for Measuring Load on a Rod - A load cell for measuring load in a rod, the load cell is described. The load cell is formed by a cylindrical strain member having a cylindrical aperture there through. The cylindrical aperture sized to fit the rod. The strain member includes a plurality of slots that create contact points there between for strain member to contact the rod in a predicable manner. A plurality of strain gages located adjacent to the contact points, the strain gages producing an electrical voltage proportional to the load on the rod. | 03-19-2015 |
Thomas Gray, Westfield, MA US
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20140190056 | STOCK ASSEMBLY AND RECOIL SYSTEM FOR A FIREARM - A stock and recoil system for a firearm includes a lower receiver, a bolt carrier, and a stock assembly. The bolt carrier is reciprocally movable along an axis within an upper receiver carried by the lower receiver and includes a tubular rearward end defining a cavity with a rearwardly directed opening. The stock assembly is coupled the lower receiver and includes a receiver extension coupled to the lower receiver and aligned on the axis. An action spring is carried within the receiver extension and extends therefrom into the tubular rearward end of the bolt carrier. The action spring is movable between a compressed configuration and an expanded configuration during the firing cycle of the firearm. A butt plate is adjustably coupled to the receiver extension and is movable between an extended position and a collapsed position. | 07-10-2014 |