Denardo, US
Andrew J. Denardo, Carmel, IN US
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20120150219 | METHOD AND APPARATUS FOR SEALING ACCESS - An apparatus and a method for sealing a puncture in a tubular tissue structure or the wall of a body cavity are provided. The apparatus and method include a bioabsorbable member that is partially external to and partially internal to an introducer sheath before and during placement thereof. | 06-14-2012 |
Andrew J. Denardo, Westfield, IN US
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20090005816 | Spinal rod, insertion device, and method of using - An apparatus and a method for fixing tissue. | 01-01-2009 |
David G. Denardo, Olivette, MO US
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20140100188 | PHENOTYPING TUMOR-INFILTRATING LEUKOCYTES - The present disclosure relates to an immune signature of tumor infiltrating leukocytes. In particular, the disclosure provides methods and kits for determining the immune signature of tumor infiltrating leukocytes for use in assessing risk of cancer recurrence and long term survival, and for developing a treatment regimen for a cancer patient. | 04-10-2014 |
David G. Denardo, San Francisco, CA US
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20120329878 | PHENOTYPING TUMOR-INFILTRATING LEUKOCYTES - The present disclosure relates to an immune signature of tumor infiltrating leukocytes. In particular, the disclosure provides methods and kits for determining the immune signature of tumor infiltrating leukocytes for use in assessing risk of cancer recurrence and long term survival, and for developing a treatment regimen for a cancer patient. | 12-27-2012 |
Gerald Denardo, Livermore, CA US
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20100184702 | Selective High-Affinity Polydentate Ligands and Methods of Making Such - This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity. | 07-22-2010 |
Gerald L. Denardo, El Macero, CA US
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20100179303 | SITE-SPECIFIC CONJUGATION OF LIGANDS TO NANOPARTICLES - A new radioconjugate NP has been developed using recombinant antibody fragments, di-scFv-c (111 In-DOTA-di-scFv-NP) for imaging and therapy of anti MUC-1 10 expressing cancers since aberrant MUC-1 Is abundantly expressed on the majority of human epithelial cancers. Selection and engineering of anti-MUC-1 di-scFv-c (50 kDa) was generated to link NP-M (maleimide). DOTA chelate was conjugated with di-scFv-c for the radiometal chelation to trace the RINP at in vivo. This RINP preparation can provide uniquely high tumor cell binding NP for AMF driven tumor hyperthermia. | 07-15-2010 |
20110144065 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH - This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity. | 06-16-2011 |
Joseph Denardo, Pagosa Springs, CO US
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20090101366 | Homeland fire suppression system - A fire suppression system for effectively subduing fires. The fire suppression system comprises an underground water tank having a first predetermined size specifically calculated to meet the needs of such property to be protected. A pre-charged foam proportioning device containing dry foam powder is engageable with the underground water tank. The system includes a system engageable with such underground water tank and with such foam proportioning device for dispensing a water/foam mixture for such property to be protected. | 04-23-2009 |
Joseph Lee Denardo, Bayfield, CO US
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20120104008 | Liquefied Gas Evacuation Assembly System for Underground Storage Tanks - An evacuation assembly for empting underground tanks of liquefied gas. The assembly not only provides ease of attaching a coupling to the underground tanks but also increases the safety of the individual attaching the coupling to the underground tank. The evacuation assembly uses a riser extension with a rotatable hose coupling mechanism to allow the coupling to be easily attached to the underground tank without the individual being exposed to volatile vapors that may have accumulated in the dome of the underground tank. | 05-03-2012 |
Matt Denardo, Cambridge, MA US
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20130103074 | METHOD AND APPARATUS FOR RESTRICTING FLOW THROUGH AN OPENING IN THE SIDE WALL OF A BODY LUMEN, AND/OR FOR REINFORCING A WEAKNESS IN THE SIDE WALL OF A BODY LUMEN, WHILE STILL MAINTAINING SUBSTANTIALLY NORMAL FLOW THROUGH THE BODY LUMEN - A device comprising a single closed loop of elastic filament configurable between (i) a first configuration for movement along a blood vessel; and (ii) a second configuration for lodging within a blood vessel, the second configuration providing a single flow-restricting face sized and configured to cover the mouth of the aneurysm and obstruct blood flow to the aneurysm while permitting substantially normal blood flow through the blood vessel, with the degree of obstruction at the mouth of the aneurysm being such that the aneurysm thromboses when the face is positioned over the aneurysm, the flow-restricting face comprising a plurality of lengths of the closed loop of filament disposed in close proximity to one another in a switchback configuration, and at least one leg for holding the flow-restricting face adjacent the mouth of the aneurysm, the leg configured so as to maintain substantially normal blood flow through the blood vessel. | 04-25-2013 |
Matthew Denardo, Watertown, MA US
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20150150436 | METHOD AND APPARATUS FOR MANIPULATING THE SIDE WALL OF A BODY LUMEN OR BODY CAVITY SO AS TO PROVIDE INCREASED VISUALIZATION OF THE SAME AND/OR INCREASED ACCESS TO THE SAME, AND/OR FOR STABILIZING INSTRUMENTS RELATIVE TO THE SAME - Apparatus comprising: a sleeve adapted to be slid over the exterior of an endoscope; a proximal balloon secured to the sleeve; an inflation/deflation tube carried by the sleeve and in fluid communication with the interior of the proximal balloon; a push tube slidably mounted to the sleeve; and a distal balloon secured to the distal end of the push tube, the interior of the distal balloon being in fluid communication with the push tube, wherein the distal balloon is capable of assuming a deflated condition and an inflated condition, and further wherein when the distal balloon is in its deflated condition, an axial opening extends therethrough, the axial opening being sized to receive the endoscope therein, and when the distal balloon is in its inflated condition, the axial opening is closed down. | 06-04-2015 |
Matthew B. Denardo, West Roxbury, MA US
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20120041258 | IMPLANTABLE ACCESS PORT SYSTEM - An implantable injection port for use with a gastric band for treating obesity and for attaching to a tissue of a patient is disclosed. The implantable injection port includes a base having an anchor opening, a gear coupled to the base and rotatable about a central axis, the gear having a plurality of gear teeth, an anchor coupled to the gear, and a top portion spaced apart from the base and having a plurality of top teeth that engage with the plurality of gear teeth. The top portion is rotatable causing rotation of the gear such that the rotation of the gear causes movement of the anchor through the anchor opening of the base and into the tissue of the patient. | 02-16-2012 |
20130281769 | IMPLANTABLE ACCESS PORT SYSTEM - An implantable injection port for use with a gastric band for treating obesity and for attaching to a tissue of a patient is disclosed. The implantable injection port includes a base having an anchor opening, a gear coupled to the base and rotatable about a central axis, the gear having a plurality of gear teeth, an anchor coupled to the gear, and a top portion spaced apart from the base and having a plurality of top teeth that engage with the plurality of gear teeth. The top portion is rotatable causing rotation of the gear such that the rotation of the gear causes movement of the anchor through the anchor opening of the base and into the tissue of the patient. | 10-24-2013 |
Nicholas M. Denardo, Mcmurray, PA US
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20140083861 | ANODIZED ALUMINUM ALLOY PRODUCTS HAVING IMPROVED APPEARANCE AND/OR ABRASION RESISTANCE, AND METHODS OF MAKING THE SAME - New methods of producing anodized aluminum alloy products having an improved surface appearance properties are disclosed. The methods may include preparing an aluminum alloy body for anodizing, thereby producing an anodized aluminum alloy body, contacting an intended viewing surface of the anodized aluminum alloy body with an acid, thereby producing a prepared intended viewing surface of the anodized aluminum alloy body, and sealing the prepared intended viewing surface of the anodized aluminum alloy body. The anodized aluminum alloy products may realize a preselected color tolerance, such as realizing a b* value that is within a specified tolerance of a preselected b* value. | 03-27-2014 |
Sally Denardo, Livermoe, CA US
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20100184702 | Selective High-Affinity Polydentate Ligands and Methods of Making Such - This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity. | 07-22-2010 |
Sally Denardo, El Macero, CA US
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20090234105 | Construction of a Multivalent SCFV Through Alkyne-Azide 1,3-Dipolar Cycloaddition - The present invention provides for a practical, universal and efficient method to ligate two large macromolecules (e.g., proteins) using the alkyne-azide 1,3-dipolar cycloaddition reaction to produce a conjugated macromolecule, such as a multivalent scFv. The present invention also provides for conjugate macromolecules comprising a plurality of macromolecule components cross-linked through at least one linking group comprising at least one 1,2,3-triazole moiety, wherein at least 50 percent of the macromolecule components in the conjugate macromolecule has only one site available for cross-linking. | 09-17-2009 |
Sally J. Denardo, El Macero, CA US
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20100179303 | SITE-SPECIFIC CONJUGATION OF LIGANDS TO NANOPARTICLES - A new radioconjugate NP has been developed using recombinant antibody fragments, di-scFv-c (111 In-DOTA-di-scFv-NP) for imaging and therapy of anti MUC-1 10 expressing cancers since aberrant MUC-1 Is abundantly expressed on the majority of human epithelial cancers. Selection and engineering of anti-MUC-1 di-scFv-c (50 kDa) was generated to link NP-M (maleimide). DOTA chelate was conjugated with di-scFv-c for the radiometal chelation to trace the RINP at in vivo. This RINP preparation can provide uniquely high tumor cell binding NP for AMF driven tumor hyperthermia. | 07-15-2010 |
20110144065 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH - This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity. | 06-16-2011 |
Scott Denardo, Bethlehem, PA US
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20090238357 | SYSTEM AND METHOD FOR IMPROVED DIRECTORY ASSISTANCE INCLUDING RE-DIAL FEATURE - A directory assistance system includes a request handling module for receiving a plurality of incoming directory assistance requests from requesters and an agent platform for handling the directory assistance requests by providing at least one listing to the requester. A record database stores a record relating to the first request, and includes a first identifier, a time and a listing entry. An incoming request tracking module tracks second incoming directory assistance requests, by reviewing a second identifier associated with the directory assistance request, comparing the second identifier against the first identifiers in the records, and if a record has a matching first identifier to second identifier from request, then, prior to the second request being sent to the agent platform, offering to automatically provide the stored listing entry from the record to the requester. | 09-24-2009 |
20120321065 | SYSTEM AND METHOD FOR IMPROVED DIRECTORY ASSISTANCE INCLUDING RE-DIAL FEATURE - A directory assistance system includes a request handling module for receiving a plurality of incoming directory assistance requests from requesters and an agent platform for handling the directory assistance requests by providing at least one listing to the requester. A record database stores a record relating to the first request, and includes a first identifier, a time and a listing entry. An incoming request tracking module tracks second incoming directory assistance requests, by reviewing a second identifier associated with the directory assistance request, comparing the second identifier against the first identifiers in the records, and if a record has a matching first identifier to second identifier from request, then, prior to the second request being sent to the agent platform, offering to automatically provide the stored listing entry from the record to the requester. | 12-20-2012 |
Thais Denardo, Plano, TX US
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20130316060 | TASTE MODIFIERS - A beverage or other composition may include phloretin and trilobtain wherein the weight ratio of phloretin to trilobtain is from about 1:1 to about 3:1. The concentration of phloretin in such a composition may be about 5 ppm to about 150 ppm. The combination of phloretin and trilobtain may remove one or more negative characteristics of the composition. | 11-28-2013 |