Otten, US
Caspar G. Otten, Santa Clara, CA US
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20160023739 | ADAPTABLE MODULAR POWER SYSTEM (AMPS) AND DEDICATED CONNECTOR; MODULAR PAYLOAD BOXES AND AUTONOMOUS WATER VEHICLE CONFIGURED TO ACCEPT SAME - An adaptable modular power system (AMPS) is hierarchical in a number of ways. AMPS modules connect to a backplane, and one or multiple AMPS backplanes can form an AMPS domain. At the same time, the vehicle electronics is modular, with various payload boxes needing to communicate with each other. A common power and signaling cable is provided to interconnect payload boxes. A dedicated connector system is also provided so that AMPS modules may communicate, control, receive data, and supply and receive power. | 01-28-2016 |
Casper G. Otten, Santa Clara, CA US
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20140284998 | Adaptable Modular Power System (AMPS) - An adaptable modular power system (AMPS) is hierarchical in a number of ways. AMPS modules connect to a backplane, and one or multiple AMPS backplanes can form an AMPS domain. At the same time, the vehicle electronics is modular, with various payload boxes needing to communicate with each other. A common power and signaling cable is provided to interconnect payload boxes. A dedicated connector system is also provided so that AMPS modules may communicate, control, receive data, and supply and receive power. | 09-25-2014 |
David L. Otten, Chandler, AZ US
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20100001889 | Current-Time Digital-to-Analog Converter - A high resolution digital-to-analog converter comprises a programmable n-bit current digital-to-analog converter (IDAC), an m-bit programmable counter/timer, an integrator that converts the IDAC constant current charging a capacitor over time into an a precision (high resolution) analog voltage, and a sample and hold circuit for storing the precision analog voltage. The constant current from the IDAC is applied to the integrator for a time period determined by the programmable counter/timer, then the sample and hold circuit will sample the final voltage on the capacitor and store it as an analog voltage. The analog voltage resolution of this high resolution digital-to-analog converter is n+m bits or binary 2 | 01-07-2010 |
David M. Otten, Newton, MA US
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20150357912 | METHOD AND APPARATUS TO PROVIDE POWER CONVERSION WITH HIGH POWER FACTOR - A power converter circuit rectifies a line voltage and applies the rectified voltage to a stack of capacitors. Voltages on the capacitors are coupled to a plurality of regulating converters to be converted to regulated output signals. The regulated output signals are combined and converted to a desired DC output voltage of the power converter. Input currents of the regulating converters are modulated in a manner that enhances the power factor of the power converter. | 12-10-2015 |
20160006365 | High-Frequency, High Density Power Factor Correction Conversion For Universal Input Grid Interface - A circuit includes a reconfigurable rectifier, a voltage balancer, and a pair of converters. The reconfigurable rectifier includes an ac input port and three output ports. In a first configuration, the reconfigurable rectifier can deliver power at a first output port and, in a second configuration, to at least a second output port. The voltage balancer includes first and second ports coupled to second and third output ports of the reconfigurable rectifier and is configured to balance received voltage at the first and second ports. The first converter has an input coupled to the first port of the voltage balancer and an output at which a first converted voltage signal is provided. The second converter has an input coupled to the second port of the voltage balancer and an output at which a second converted voltage signal is provided. | 01-07-2016 |
Dennis D. Otten, Elk River, MN US
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20100018922 | Method and apparatus for processing vegetable oil miscella, method for conditioning a polymeric microfiltration membrane, membrane, and lecithin product - A method for processing vegetable oil miscella is provided. The method includes steps of feeding vegetable oil miscella to a conditioned polymeric microfiltration membrane, and recovering a permeate stream having a decreased weight percent of phospholipids compared with the weight percent of phospholipids provided in the miscella. The retentate stream can be further processed for the recovery of lecithin. The polymeric microfiltration membrane can be conditioned for the selective separation of phospholipids in the miscella. A method for conditioning a membrane for selective separation of phospholipids from vegetable oil miscella, and the resulting membrane, are provided. The membrane which can be conditioned can be characterized as having an average pore size of between about 0.1μ and about 2μ. | 01-28-2010 |
Gillis Otten, Rowley, MA US
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20130122042 | BENZONAPTHYRIDINE COMPOSITIONS AND USES THEREOF - The present invention generally relates to compositions comprising benzonapthyridine small molecule immune potentiators (SMIPs) that are capable of stimulating or modulating an immune response in a subject that has had pre- or post-exposure to a pathogen such as hemorrhagic fever virus. Also provided are methods of preparing and using the SMIP compositions of the invention. | 05-16-2013 |
20130177639 | DELIVERY OF RNA TO TRIGGER MULTIPLE IMMUNE PATHWAYS - RNA encoding an immunogen is co-delivered to non-immune cells at the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g. by a single injection. | 07-11-2013 |
20130177640 | DELIVERY OF RNA TO DIFFERENT CELL TYPES - RNA encoding an immunogen is co-delivered to non-immune cells at the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g. by a single injection. | 07-11-2013 |
20140242152 | IMMUNOGENIC COMPOSITIONS AND USES THEREOF - This invention generally relates to immunogenic compositions that comprise an RNA component and a polypeptide component. Immunogenic compositions that deliver antigenic epitopes in two different forms—a first epitope from a pathogen, in RNA-coded form; and a second epitope from the same pathogen, in polypeptide form—are effective in inducing immune response to the pathogen. The invention also relates to a kit comprising an RNA-based priming composition and a polypeptide-based boosting composition. The kit may be used for sequential administration of the priming and the boosting compositions. | 08-28-2014 |
20150140068 | IMMUNOGENIC COMPOSITIONS AND USES THEREOF - This invention generally relates to immunogenic compositions that comprise an HIV RNA component and a HIV polypeptide component. Immunogenic compositions that deliver antigenic epitopes in two different forms—a first epitope from human immunodeficiency virus (HIV), in RNA-coded form; and a second epitope from HIV, in polypeptide form—are effective in inducing immune response to HIV. The invention also relates to a kit comprising an HIV RNA-based priming composition and an HIV polypeptide-based boosting composition. The kit may be used for sequential administration of the priming and the boosting compositions. | 05-21-2015 |
Gillis Otten, Foster City, CA US
Patent application number | Description | Published |
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20080226598 | Compositions and methods for generating an immune response utilizing alphavirus-based vector systems - Methods are provided for generating immune responses utilizing alphavirus-based vector systems. | 09-18-2008 |
20100266631 | Compositions and Methods for Generating an Immune Response Utilizing Alphavirus-Based Vector Systems - Compositions and methods are provided for Eukaryotic Layered Vector Initiation Systems and Alphavirus replicon particles for introducing heterologous sequences into cells for generating immune responses. | 10-21-2010 |
Glenn A. Otten, The Woodlands, TX US
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20080207970 | Heating an organic-rich rock formation in situ to produce products with improved properties - A method of producing hydrocarbon fluids with improved hydrocarbon compound properties from a subsurface organic-rich rock formation, such as an oil shale formation, is provided. The method may include the step of heating the organic-rich rock formation in situ. In accordance with the method, the heating of the organic-rich rock formation may pyrolyze at least a portion of the formation hydrocarbons, for example kerogen, to create hydrocarbon fluids. Thereafter, the hydrocarbon fluids may be produced from the formation. Hydrocarbon fluids with improved hydrocarbon compound properties are also provided. | 08-28-2008 |
20100095742 | Testing Apparatus For Applying A Stress To A Test Sample - A testing apparatus which is suitable for applying a stress load to a test specimen is provided. The testing apparatus may be used to simulate lithostatic stress on a test specimen, which may be, for example, a portion of a geologic formation. The testing apparatus may also be used in a method of evaluating the expected production of fluids obtainable from in situ pyrolysis of oil shale. | 04-22-2010 |
20100101793 | Electrically Conductive Methods For Heating A Subsurface Formation To Convert Organic Matter Into Hydrocarbon Fluids - A method and system for heating a subsurface formation using electrical resistance heating is provided. In one aspect, two or more wellbores are provided that penetrate an interval of solid organic-rich rock within the subsurface formation. At least one fracture is established in the organic-rich rock from at least one of the wellbores, and electrically conductive material is provided in the fracture. In this way electrical communication is provided between the two or more wellbores. The electrically conductive material may include a first portion placed in contact with each of the two or more wellbores, and a second portion intermediate the two or more wellbores. The first portion has a first bulk resistivity while the second portion has a second bulk resistivity. The method also includes passing electric current through the fracture such that heat is generated by electrical resistivity within the electrically conductive material sufficient to pyrolyze at least a portion of the organic-rich rock into hydrocarbon fluids. The resistive heat generated within the first portion of the electrically conductive material is less than the heat generated within the second portion of the electrically conductive material. | 04-29-2010 |
20120267110 | Heating An Organic-Rich Rock Formation In Situ To Produce Products With Improved Properties - A method of producing hydrocarbon fluids with improved hydrocarbon compound properties from a subsurface organic-rich rock formation, such as an oil shale formation, is provided. The method may include the step of heating the organic-rich rock formation in situ. In accordance with the method, the heating of the organic-rich rock formation may pyrolyze at least a portion of the formation hydrocarbons, for example kerogen, to create hydrocarbon fluids. Thereafter, the hydrocarbon fluids may be produced from the formation. Hydrocarbon fluids with improved hydrocarbon compound properties are also provided. | 10-25-2012 |
Gregory K. Otten, Houston, TX US
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20130139359 | BUOYANT CLAMP FOR TUBULAR MEMBERS - Various clamps for connecting one tubular member to another, methods of using and making such clamps are disclosed. In one aspect a clamp for coupling a first tubular member to a second tubular member is provided. The clamp includes a first clamp half and a second clamp half engageable with the first clamp half. The first and second clamp halves define a first through bore to accommodate the first tubular member and a second through bore to accommodate the second tubular member. A strap is adapted to circumscribe at least a portion of and bring into engagement the first and second clamp halves. The clamp is buoyant in water. | 06-06-2013 |
Jay G. Otten, Flat Rock, MI US
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20120251479 | Reduced-Odor Polyol Composition And Method Of Producing Same - A reduced-odor polyol composition for gastrointestinal lavage of a mammal comprises a polyol and at least one acid salt formed from a reaction between a basic catalyst and citric acid. The reduced-odor polyol composition is produced by providing at least one alkylene oxide; providing at least one initiator; reacting the at least one alkylene oxide with the at least one initiator in the presence of a basic catalyst to produce a polyol; and neutralizing the basic catalyst with citric acid, thereby forming at least one acid salt and producing the reduced-odor polyol composition. | 10-04-2012 |
Jay Gregory Otten, Brownstown Township, MI US
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20090005482 | Method of Drying an Absorbent Polymer with a Surfactant - A method of drying an absorbent polymer includes providing the absorbent polymer. A surfactant having a C | 01-01-2009 |
Jay Gregory Otten, Flat Rock, MI US
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20100216949 | Method Of Making An Alkoxylated Polyethylenimine Product - A method of making an alkoxylated polyethyleneimine (APEI) product having reduced discoloration includes treating a composition including a component selected from the group of polyethyleneimine (PEI), alkoxylated polyethyleneimine (APEI) intermediate, and combinations thereof that is used to make the APEI product. The method of treating the composition includes adding water to the composition in an amount of from 2 to 20 parts by weight, based on the total weight of the composition. The water is stripped from the composition within a relatively low temperature range of from 158 to 203° F. until less than or equal to 0.2 parts by weight of water, based on the total weight of the composition, is present in the composition. The aqueous solutions of APEI product thus made have Gardner color values of less than 6. | 08-26-2010 |
Jeffrey Douglas Otten, Cypress, TX US
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20140010597 | Top-Tensioned Riser System - A top-tensioned riser (TTR) is supported by a tensioning system on the deck of a floating platform. The tension ring may include an elastomeric layer which permits small angular and lateral displacements of the tension joint. The tension joint comprises a tapered section to resist the bending moment and shear imposed by the vessel's motion. The riser tension joint may be supported laterally by rollers below the tension ring. The rollers react on the tapered section when the riser strokes up and down. The tapered section may be engineered to maximize the use of the tension joint, and to reduce bending moment and shear loads imposed on the tensioning system. In certain embodiments, there may be a small gap between the rollers and the tapered section. In certain other embodiments, the rollers may be spring-loaded to increase the stability of surface equipment on the upper terminus of the riser. | 01-09-2014 |
20140305655 | RISER TENSIONER CONDUCTOR FOR DRY-TREE SEMISUBMERSIBLE - A top-tensioned riser system comprises a substantially vertical riser extending upward from the seafloor; a conductor surrounding an upper portion of the riser in spaced-apart relation; a coaxial keel guide surrounding a lower portion of the conductor; a tensioner attached to the conductor and the riser; a keel guide support structure attached to the keel guide and connected to the keel of a dry-tree, semi-submersible vessel; and, a keel joint centralizer attached to the riser proximate the keel guide and sized to prevent radial movement of the riser relative to the conductor. Side loads on the riser (such as those arising from displacement of the vessel from its nominal position or currents acting on the riser) are reacted from the riser to the conductor via the keel joint centralizer and thence to the keel of the vessel via the keel guide. | 10-16-2014 |
Josephus Marinus Otten, Gaithersburg, MD US
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20090246076 | ELECTROCHEMILUMINESCENCE FLOW CELL AND FLOW CELL COMPONENTS - An electrochemiluminescence cell comprising an electrode capable of inducing an electrochemiluminescence-active species to electrochemiluminesce. The electrode is preferably made of rhodium, iridium or an alloy of platinum, rhodium or iridium alloyed with an alloy material comprising a transition element. The electrode may be used as counter electrode and/or as a working electrode in the electrochemiluminescence cell. The cell preferably includes a counter electrode and a support attached to the counter electrode. The support comprises a transparent portion in optical registration with the working electrode. The counter electrode may include one or more field extending elements interposed between the transparent portion and the working electrode. The field extending element is preferably a ladder or a grid. | 10-01-2009 |
Kim Otten, Chandler, AZ US
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20140270253 | Flexible Clocking for Audio Sample Rate Converter in a USB System - A processor according to embodiments comprises an on-board sample rate converter for converting a source audio signal that is sampled at a first sampling rate to an output audio signal that is sampled at a second sampling rate. The sample rate converter utilizes a master clock signal in converting the audio signal. The sample rate converter selects the master clock signal from available reference clock signals, such as an on-chip system clock or a bus interface clock, and scales the frequency of the selected clock signal to generate the master clock signal with the frequency of the second sampling rate. | 09-18-2014 |
Lynn M. Otten, Tucson, AZ US
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20150283389 | USER INTERFACE WITH 3D ENVIRONMENT FOR CONFIGURING STIMULATION THERAPY - The disclosure describes a method and system that allows a user to configure electrical stimulation therapy by defining a three-dimensional (3D) stimulation field. After a stimulation lead is implanted in a patient, a clinician manipulates the 3D stimulation field in a 3D environment to encompass desired anatomical regions of the patient. In this manner, the clinician determines which anatomical regions to stimulate, and the system generates the necessary stimulation parameters. In some cases, a lead icon representing the implanted lead is displayed to show the clinician where the lead is relative to the 3D anatomical regions of the patient. | 10-08-2015 |
Lynn M. Otten, Blaine, MN US
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20110034981 | Apparatus for Securing a Therapy Delivery Device Within a Burr Hole and Method for Making Same - Apparatus for securing a therapy delivery device relative to a burr hole and method for making same. In one embodiment, the apparatus includes a base for seating in or near the burr hole. The apparatus may further include a stabilizer that may be engaged with the therapy delivery device. The stabilizer may include a surface coating or treatment operable to enhance frictional engagement with the therapy delivery device. | 02-10-2011 |
20140107731 | USER INTERFACE WITH 3D ENVIRONMENT FOR CONFIGURING STIMULATION THERAPY - The disclosure describes a method and system that allows a user to configure electrical stimulation therapy by defining a three-dimensional (3D) stimulation field. After a stimulation lead is implanted in a patient, a clinician manipulates the 3D stimulation field in a 3D environment to encompass desired anatomical regions of the patient. In this manner, the clinician determines which anatomical regions to stimulate, and the system generates the necessary stimulation parameters. In some cases, a lead icon representing the implanted lead is displayed to show the clinician where the lead is relative to the 3D anatomical regions of the patient. | 04-17-2014 |
Mark A. Otten, Crooks, SD US
Patent application number | Description | Published |
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20100115907 | Self-cleaning mower ground roller assembly mounting system - A self-cleaning mounting system for a ground roller assembly to be used on a mower such as a flail mower including a stationary sleeve bearing positioned on mounting shafts extending from either end of the ground roller. The stationary sleeve bearing is positioned in a housing which is vertically positionably with respect to the mower housing. The housing includes a stationary helical flight and a seal guard which fits within the ground roller. The stationary sleeve bearing is protected on either end from dirt and debris getting between the inside surface of the stationary sleeve bearing and the outside surface of the mounting shafts on either end of the ground roller. | 05-13-2010 |
20100115908 | Mower ground roller assembly mounting system - A mounting system for a ground roller assembly to be used on a mower such as a flail mower including a stationary sleeve bearing positioned on mounting shafts extending from either end of the ground roller. The stationary sleeve bearing is positioned in a housing which is vertically positionably with respect to the mower housing. The stationary sleeve bearing is protected on either end from dirt and debris getting between the inside surface of the stationary sleeve bearing and the outside surface of the mounting shafts on either end of the ground roller. | 05-13-2010 |
Martin Otten, Seattle, WA US
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20090328227 | ANTI-PIRACY MEASURES FOR A VIDEO GAME USING HIDDEN SECRETS - Embodiments are directed towards employing hidden secrets on a client device to detect and deter piracy of a computer application. The computer application is partitioned into components, where a subset of the components is initially provided to the client device. In one embodiment, the computer application is unable to execute properly within the removed or other set of components. The removed components not provided to the client device may then be modified based on hidden secrets information and a verification component and provided over a network to the client device. If the verification component is unable to locate an armed secret, or detects that an armed secret is modified, the computer application may be inhibited from installation and/or execution. In one embodiment, a secret might be unarmed, such that its presence, absence, and/or modification might be ignored. | 12-31-2009 |
20100041457 | OVERLAYING INTERACTIVE VIDEO GAME PLAY WITH REAL-TIME CHAT SESSIONS WITH GAME SWITCHING - Embodiments are directed towards providing an interactive game experience whereby a game player may combine game play with a user interface overlaid onto the game that is useable to interact and communicate with other players inside and/or outside of the current game. Through the use of the user interface, a player may select different game sets to play, and rapidly switch between games with different players, while maintaining a real-time interactive chat session, or similar communication session, including, without limit, voice communication sessions. A game client component may launch a game, and then hooks into the game to intercept various input and video functions. | 02-18-2010 |
20100162405 | PROTECTING AGAINST POLYMORPHIC CHEAT CODES IN A VIDEO GAME - Embodiments are directed towards protecting against polymorphic cheat codes in a video game environment. A detour analyzer analyzes game code in client memory for possible hooks to parasite code. For each detected hook to parasite code, hook and/or parasite information is determined to generate a hook/parasite signatures, which are sent to a remote network device. Based on the hook/parasite signatures a weighted combination of scores are generated that is useable to determine a probability value that the parasite code is cheat code. If the determined probability value indicates cheat code, the user of the client device may be banned from future game play. Additionally, the hook/parasite signature information may be used to update the data store to detect polymorphic changes in the cheat code. | 06-24-2010 |
Matthew Otten, Cincinnati, OH US
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20130066230 | SINGLE PIECE BIOPSY FORCEPS - Single piece biopsy forceps having jaws that are caused to open and close in response to longitudinal movement of an actuation rod. The single piece forceps are formed from a single metal blank with opposing jaw sections connected via a self-hinge. The metal blank includes a self-hinge portion, a channel section on either end of the hinge portion and a jaw section on distal ends of the channel sections. The jaws are formed from the jaw section of the metal blank and the channel sections are bent to provide generally U-shaped channel sections. The hinge portion is bent so that the jaws are oriented in opposed aligned relation. A fixed and a movable pin are disposed through slots in the channel sections. Movement of the movable pin with respect to the fixed pin via an actuator rod or wire causes the jaws of the biopsy forceps to open and close. | 03-14-2013 |
20130131544 | BIOPSY FORCEPS INCLUDING SELF ALIGNING JAWS WITH DRAINAGE OPENINGS - Improved biopsy forceps include pivotally coupled self aligning jaws with drainage holes therethrough. The biopsy forceps include a pair of jaw members that include cup shaped jaws. The biopsy forces may be formed by a series of metal etching and forming operations to allow the manufacture of the biopsy forceps using high volume manufacturing techniques. | 05-23-2013 |
Matthew R. Otten, Cincinnati, OH US
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20150223672 | ANTI-FOG FILM FOR AN ENDOSCOPE - An endoscope comprising a lens, and an anti-fog film, wherein an optically clear adhesive bonds the anti-fog film to the lens or lens section. | 08-13-2015 |
Michael Otten, Scarsdale, NY US
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20100004970 | METHOD AND STRUCTURE FOR IMPLEMENTING B2B TRADING PARTNER BOARDING - A computerized method (and structure) of implementing a business-to-business (B2B) boarding process includes providing a set of questions related to the B2B boarding process to a new business to be boarded into an existing B2B system. | 01-07-2010 |
Paul D. Otten, San Jose, CA US
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20120032098 | Inline Aseptic Valve - Inline valve assembly having a body with an axial bore and guide slots extending in a direction perpendicular to the bore, a flexible tubular liner having an axially extending flow passageway with a generally cylindrical side wall disposed in and supported by the bore, throttling pins mounted in the guide slots in engagement with the side wall on opposite sides of the liner, and cam members rotatively mounted on the valve body for urging the pins together against the side wall to restrict flow through the passageway | 02-09-2012 |
Pieter Albert Otten, King, NC US
Patent application number | Description | Published |
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20110281895 | SYNTHESIS AND NOVEL SALT FORMS OF (R)-5-((E)-2-PYRROLIDIN-3YLVINYL)PYRIMIDINE - The present invention relates to the stereospecific synthesis of (R)-5-((E)-2-pyrrolidin-3-yl)pyrimidine, novel salt forms, and novel polymorphic forms of these salts. | 11-17-2011 |
20120015983 | Synthesis and Novel Salt Forms of (R)-3-((E)-pyrrolidin-3-yl)vinyl)-5-tetrahydropyran-4-yloxy)pyridine - The present invention relates to (R)-3-((E)-2-(pyrrolidin-3-yl)vinyl)-5-(tetrahydropyran-4-yloxy)pyridine, its salt forms, and to processes for the commercial-scale production of these compounds in sufficient purity and quality for use in pharmaceutical compositions. | 01-19-2012 |
20140066460 | SYNTHESIS AND NOVEL SALT FORMS OF (R)-5-((E)-2-PYRROLIDIN-3YLVINYL)PYRIMIDINE - The present invention relates to the stereospecific synthesis of (R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine, its salt forms, and novel polymorphic forms of these salts. | 03-06-2014 |
20140107163 | SYNTHESIS AND NOVEL SALT FORMS OF (R)-3-((E)-2-(PYRROLIDIN-3-YL)VINYL)-5-(TETRAHYDROPYRAN-4-YLOXY)PYRIDINE - The present invention relates to (R)-3-((E)-2-(pyrrolidin-3-yl)vinyl)-5-(tetrahydropyran-4-yloxy)pyridine, its salt forms, and to processes for the commercial-scale production of these compounds in sufficient purity and quality for use in pharmaceutical compositions. | 04-17-2014 |
Ronald A. Otten, Villa Rica, GA US
Patent application number | Description | Published |
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20150272972 | INHIBITION OF HIV INFECTION THROUGH CHEMOPROPHYALXIS - A process is provided for protecting a primate host from a self-replicating infection by an immunodeficiency retrovirus. Protection is achieved by administering to the primate host a combination of a pharmaceutically effective amount of a nucleoside reverse transcriptase inhibitor and a pharmaceutically effective amount of a nucleotide reverse transcriptase inhibitor prior to exposure to the immunodeficiency retrovirus. The administration is effective if provided in a single dose within 24 hours of the exposure. A regime of regular daily doses is also effective in providing protection against an immunodeficiency retrovirus becoming self-replicating after infecting a primate host. A process for controlling retrovirus transmission within a population includes the administration to a subpopulation at high risk for contracting an immunodeficiency retroviral infection the detailed combination prior to sexual exposure to a source of immunodeficiency retrovirus so as to preclude the immunodeficiency retrovirus from becoming self-replicating in a member of the subpopulation. | 10-01-2015 |
Sjef Otten, Gaithersburg, MD US
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20130315780 | DIAGNOSTIC SYSTEMS AND INSTRUMENTS - Provided is a clinical diagnostic system that comprises a diagnostic instrument and a disposable cartridge. The diagnostic system can be used to measure assays in point of care clinical settings. | 11-28-2013 |
20150132860 | CLINICAL DIAGNOSTIC SYSTEM INCLUDING INSTRUMENT AND CARTRIDGE - In embodiments disclosed herein, a diagnostic system is provided having a cartridge comprising at least one needle; at least one reservoir; at least one fluidic seal; and at least one fluidic channel of a fluidic pathway, wherein the cartridge is configured to store at least one reagent and at least one waste material on the cartridge. The diagnostic system is provided also having a diagnostic instrument comprising the fluidic pathway; an electrochemiluminescence (ECL) detection system; and a pump, wherein the fluidic pathway begins and ends in the cartridge and has a substantially single direction of flow in a pathway fluidically connecting the diagnostic instrument and the cartridge. | 05-14-2015 |
20150132861 | CLINICAL DIAGNOSTIC SYSTEMS - A diagnostic system is provided herein that includes an instrument comprising an electrochemiluminescence (ECL) detector, and a cartridge configured to fit within a portion of the instrument, wherein the cartridge includes at least one reagent including an ECL label and a blood collection holder. Also provided herein is a system that includes a diagnostic instrument, which includes a pump, an ECL detector, an incubator, a magnet, and an output device, and a cartridge configured to fit within a portion of the diagnostic instrument, a sample holder configured to fit within the cartridge, and a closed fluidic loop between the diagnostic instrument and the cartridge when the cartridge is fit within a portion of the diagnostic instrument, wherein the cartridge is configured to accept a sample from the sample holder and place the sample in fluidic communication with the diagnostic instrument via the closed fluidic loop. | 05-14-2015 |
Tammy M. Otten, Bonner Springs, KS US
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20140036697 | Traffic Management of Third Party Applications - A proxy server for routing traffic between a mobile device and a network, comprising at least one processor, a memory, and a traffic monitoring application stored in the memory that, when executed by the at least one processor, monitors a plurality of mobile device installed applications that run on the mobile device and the mobile device installed applications' traffic, analyzes traffic usage for the mobile device installed applications, identifies the mobile device installed applications responsible for traffic that is excessive or unnecessary as determined by the mobile device's service provider, and blocks, delays, or reports the excessive and unnecessary traffic without interrupting the mobile device's communications. | 02-06-2014 |