Patent application number | Description | Published |
20080308846 | DEVICE AND METHOD FOR DETECTING BIOMOLECULES USING ADSORPTIVE MEDIUM AND FIELD EFFECT TRANSISTOR - A device for detecting biomolecules includes: a semiconductor substrate; a source region and a drain region separately provided at the substrate; a chamber formed at the substrate including a region between the source region and the drain region, the chamber configured to contain a sample including the biomolecules; and an electrode which applies a voltage to the sample in the chamber. The biomolecules are mobile with respect to the electrode and sample. Methods for detecting biomolecules are also disclosed. | 12-18-2008 |
20080315861 | BIOMOLECULE DETECTOR BASED ON FIELD EFFECT TRANSISTOR ARRAYS CONTAINING REFERENCE ELECTRODES AND DETECTION METHOD FOR BIOMOLECULES USING THE SAME - A biomolecule detector and a method thereof are provided to detect the biomolecules in a liquid sample using a field effect transistor (FET) array. The FET array is characterized in that the transistor used has no gate electrode layer, a reference electrode is provided in the space between the transistors in the array instead of the gate electrode layer. Using the FET array, the existence of the biomolecules in the sample can be detected electrically and effectively under the circumstance where an external voltage is applied to flow the biomolecules. Using the FET array to detect the biomolecules, the deviation for each transistor is reduced and the multiplex processing is also possible to measure the plurality of analyzing samples at the same time. | 12-25-2008 |
20090005265 | METHOD OF ISOLATING NUCLEIC ACID USING MATERIAL POSITIVELY CHARGED AT FIRST PH AND CONTAINING AMINO GROUP AND CARBOXYL GROUP - A method of isolating nucleic acid from a sample containing nucleic acid is provided. The method includes contacting the sample with a bifunctional material that contains an amino group and a carboxyl group and is positively charged at a first pH to allow binding of the nucleic acid to the bifunctional material; and extracting the nucleic acid at a second pH higher than the first pH from the complex. | 01-01-2009 |
20090090175 | METHOD AND A DEVICE FOR DETECTING GENES - A method and a device for detecting nucleic acid are disclosed, wherein impurities in a sample can be easily removed.. The method comprises injecting a sample containing an adsorption medium with nucleic adsorbed thereon into a chamber; washing the sample; heating the sample to denature the nucleic acid; cooling down; and detecting nucleic acid by using the biomolecule detection device. The device includes: a source and a drain region; a gate electrode layer; a chamber formed over the semiconductor substrate including the gate electrode layer; and a heating means, wherein a gate adsorption layer to which a nucleic acid is adsorbed is formed on the gate electrode layer. A single-stranded nucleic acid is adsorbed to the gate adsorption layer, and a channel is formed between the source and the drain region. The current in the channel provides a basis to detect a gene. | 04-09-2009 |
20090122828 | METHOD FOR IDENTIFYING A BIOMOLECULE - A method for identifying a biomolecule using a biomolecule detector having a field effect transistor (FET) is provided. The method comprises the steps of (a) heating a sample containing a biomolecule loaded in the detector to thereby elevate the temperature of the sample; (b) measuring electric current flowing through a channel formed between a source region and a drain region in the FET while raising the temperature in the step (a); (c) obtaining a transition temperature that is the temperature at maximum point of current variation from data measured in the step (b); and (d) identifying the biomolecule using the transition temperature obtained in the step (c). | 05-14-2009 |
20090153130 | FIELD EFFECT TRANSISTOR-BASED BIOSENSOR WITH INORGANIC FILM, METHOD OF MANUFACTURING THE BIOSENSOR, AND METHOD OF DETECTING BIOMOLECULE USING THE BIOSENSOR - Provided is a Field-Effect Transistor (FET)-based biosensor including: a substrate; a source and a drain, disposed on the substrate, having opposite polarity to the substrate; a gate, disposed on the substrate, contacting the source and the drain; and an inorganic film capable of binding with a biomolecule, disposed on a surface of the gate. A method of manufacturing the FET-based biosensor and a method of detecting a biomolecule using the FET-based biosensor is also provided. The FET-based biosensor can be manufactured using a semiconductor fabrication process without performing an additional process. Therefore, the inorganic film can be selectively deposited on a surface of a specific gate of a single FET, or on the surfaces of some gates of a plurality of FETs using patterning. Furthermore, the FET-based biosensor can be used to effectively detect trace amounts of a target biomolecule in a sample. | 06-18-2009 |
20090170211 | SENSING SWITCH AND DETECTING METHOD USING THE SAME - Provided are a sensing switch and a sensing method using the same. The sensing switch includes: a substrate; a supporter on the substrate; a sensing plate that is connected to a side of the supporter and is in parallel with the substrate by a predetermined distance; a receptor binding region on an upper surface of an end portion of the sensing plate; an electric or magnetic field generation device that induces deflection of the sensing plate when a receptor bound to the receptor binding region is selectively bound to an electrically or magnetically active ligand; and a pair of switching electrodes that are separated by a predetermined distance and is connected when the sensing plate contacts the substrate due to the deflection of the sensing plate. A target material need not be labelled, a signal processing of a fluorescent or electrical detection signal using an analysis apparatus is not required, and a signal can be directly decoded by confirming whether a current flows through the switch. | 07-02-2009 |
20090246889 | SUBSTRATE HAVING OXIDE LAYER, METHOD FOR DETECTING TARGET MATERIAL USING THE SUBSTRATE, AND OPTICAL SENSOR INCLUDING THE SUBSTRATE - Provided are a substrate used in optically detecting a target material and having an oxide layer, a method for detecting a target material using the substrate, and an optical sensor including the substrate. The substrate can provide an increased detection signal in an analysis method using the substrate. | 10-01-2009 |
20090322354 | METHOD OF DETECTING BIO-MOLECULES USING FIELD EFFECT TRANSISTOR WITHOUT FIXING PROBE BIO-MOLECULES ON THE GATE SENSING SURFACE - A method of detecting a presence of bio-molecules, or a concentration of the target bio-molecules using a field effect transistor, includes allowing a first sample including a first target bio-molecule to contact a sensing surface of the field effect transistor and measuring a change in an electric signal of the field effect transistor, the field effect transistor including a substrate, a source region and a drain region, the source region and the drain region formed apart from each other on the substrate, the source region and the drain region each doped to having an opposite polarity than a polarity of the substrate, a channel region disposed between the source region and the drain region and an insulating layer including the sensing surface, the insulating layer disposed on the channel region. | 12-31-2009 |
20100181209 | METHOD OF ELECTRICALLY DETECTING BIOMOLECULE - Provided is a method of sensing biomolecules using a bioFET, the method including: forming a layer including Au on a gate of the bioFET; forming a probe immobilized on a substrate separated from the gate by a predetermined distance, and a biomolecule having a thiol group (—SH) which is incompletely bonded to the probe; reacting the probe with a sample including a target molecule; and measuring a current flowing in a channel region between a source and a drain of the bioFET. | 07-22-2010 |
20100183812 | APPARATUS FOR CALIBRATING OPTICAL SCANNER, METHOD OF MANUFACTURING THE SAME, AND METHOD OF CALIBRATING OPTICAL SCANNER USING THE SAME - Provided is a calibration apparatus for an optical scanner, including a substrate on which a molecule capable of forming an excimer is immobilized. A method of manufacturing the calibration apparatus and a method of calibrating an optical scanner using the calibration apparatus are also provided. | 07-22-2010 |
20100289509 | METHOD FOR POSITIONING CARBON NANOTUBES BETWEEN ELECTRODES, BIOMOLECULE DETECTOR BASED ON CARBON NANOTUBE-PROBE COMPLEXES AND DETECTION METHOD USING THE SAME - A device and method are disclosed for detecting biomolecules. More specifically, by measuring the change in the electrical properties of a complex between a probe and carbon nanotubes, a non-label detection is achieved, capable of a rapid, sensitive and electrical detection of the presence and concentration of biomolecules in a sample solution. | 11-18-2010 |
20100329931 | SENSING SWITCH AND DETECTING METHOD USING THE SAME - Provided are a sensing switch and a sensing method using the same. The sensing switch includes: a substrate; a supporter on the substrate; a sensing plate that is connected to a side of the supporter and is in parallel with the substrate by a predetermined distance; a receptor binding region on an upper surface of an end portion of the sensing plate; an electric or magnetic field generation device that induces deflection of the sensing plate when a receptor bound to the receptor binding region is selectively bound to an electrically or magnetically active ligand; and a pair of switching electrodes that are separated by a predetermined distance and is connected when the sensing plate contacts the substrate due to the deflection of the sensing plate. A target material need not be labelled, a signal processing of a fluorescent or electrical detection signal using an analysis apparatus is not required, and a signal can be directly decoded by confirming whether a current flows through the switch. | 12-30-2010 |
20110043213 | FET-BASED SENSOR FOR DETECTING IONIC MATERIAL, IONIC MATERIAL DETECTING DEVICE USING THE FET-BASED SENSOR, AND METHOD OF DETECTING IONIC MATERIAL USING THE FET-BASED SENSOR - Provided are a FET-based sensor for detecting an ionic material, an ionic material detecting device including the FET-based sensor, and a method of detecting an ionic material using the FET-based sensor. The FET-based sensor includes: a sensing chamber including a reference electrode and a plurality of sensing FETs; and a reference chamber including a reference electrode and a plurality of reference FETs. The method includes: flowing a first solution into and out of the sensing chamber and the reference chamber of the FET-based sensor; flowing a second solution expected to contain an ionic material into and out of the sensing chamber while continuously flowing the first solution into and out of the reference chamber; measuring a current in a channel region between the source and drain of each of the sensing and reference FETs; and correcting the current of the sensing FETs. | 02-24-2011 |
20110237460 | MICROARRAY PACKAGE DEVICE AND METHOD OF MANUFACTURING THE SAME - A microarray package device and a method of manufacturing the same. An effective microarray analyzing reaction is performed by using the microarray package device that provides structural stability and reliable experimental results. | 09-29-2011 |
20110304849 | DEVICE FOR CALIBRATING OPTICAL SCANNER, METHOD OF MANUFACTURING THE DEVICE, AND METHOD OF CALIBRATING OPTICAL SCANNER USING THE DEVICE - A device for calibrating an optical scanner includes a substrate; and a pattern disposed on the substrate, the pattern comprising a photoresist. | 12-15-2011 |
20120078527 | KIT AND METHOD FOR PREDICTING SENSITIVITY OF GASTRIC CANCER PATIENT TO ANTI-CANCER AGENT - A kit and method for predicting the sensitivity of gastric cancer patient to an anti-cancer agent are disclosed. | 03-29-2012 |
20120146162 | NANOSENSOR AND METHOD OF MANUFACTURING THE SAME - A nanosensor comprising a substrate in which an opening defining a hole is formed; a first layer disposed on the substrate, which comprises a first nanopore in communication with the hole in the substrate; and a second layer contacted or coupled with the first layer and formed of a porous material. | 06-14-2012 |
20120325664 | NANOSENSOR AND METHOD OF MANUFACTURING THE SAME - A nanosensor comprising a substrate having a hole; a first insulating layer disposed on the substrate and having a first nanopore at a location corresponding to the hole in the substrate; first and second electrodes disposed on the first insulating layer, wherein the first and second electrodes are spaced apart from each other with the first nanopore positioned therebetween; a first electrode pad disposed on at least a portion of the first electrode; a second electrode pad disposed on at least a portion of the second electrode; and a protective layer disposed on at least a portion of the first and second electrode pads; as well as a method for manufacturing same. | 12-27-2012 |
20120326732 | NANOSENSOR AND METHOD OF DETECTING TARGET MOLECULE BY USING THE SAME - The present disclosure includes a sensor and method for detecting a target molecule. In one instance, a sensor comprises a substrate including a hole, a first insulating layer located on the substrate and including a first nanopore corresponding to the hole, a first electrode, a second electrode, wherein the first electrode and the second electrode are located on a surface of the first insulating layer and are spaced apart by the first nanopore forming a nanogap, and a modulation unit configured to apply a unit input signal between the first electrode and the second electrode, wherein at least one unit input signal is applied as a target molecule passes through the nanogap. | 12-27-2012 |
20130161192 | APPARATUS AND METHOD FOR LINEARLY TRANSLOCATING NUCLEIC ACID MOLECULE THROUGH AN APERTURE - An apparatus and method for linearly translocating nucleic acid molecules through an aperture at a reduced rate. | 06-27-2013 |
20130161194 | NANOPORE DEVICE, METHOD OF FABRICATING THE SAME, AND DNA DETECTION APPARATUS INCLUDING THE SAME - A nanopore device including a nanopore formed by penetrating a thin layer, a nanochannel formed at an entrance of the nanopore, and a filler in the nanochannel, as well as a method of fabricating the nanopore device and an apparatus including the nanopore device. | 06-27-2013 |
20130264206 | BIOMOLECULE DETECTION APPARATUS INCLUDING PLURALITY OF ELECTRODES - A biomolecule detection apparatus comprising a nanopore device having a front surface and rear surface and including a nanopore having a nano-sized diameter; a reservoir disposed adjacent to a rear surface of the nanopore device; and a power supply unit comprising a first electrode disposed in a front of the nanopore device; a second electrode disposed inside the reservoir; and a third electrode disposed adjacent the nanopore and between the first electrode and the second electrode; as well as a method of using the biomolecule detection apparatus to detect a biomolecule in a sample. | 10-10-2013 |
20130265031 | NANOGAP SENSOR AND METHOD OF MANUFACTURING THE SAME - A nanogap sensor includes a first layer in which a micropore is formed; a graphene sheet disposed on the first layer and including a nanoelectrode region in which a nanogap is formed, the nanogap aligned with the micropore; a first electrode formed on the grapheme sheet; and a second electrode formed on the graphene sheet, wherein the first electrode and the second electrode are connected to respective ends of the nanoelectrode region. | 10-10-2013 |
20130334047 | DEVICE FOR DETERMINING A MONOMER MOLECULE SEQUENCE OF A POLYMER COMPRISING DIFFERENT ELECTRODES AND USE THEREOF - Provided is a device for determining a monomer molecule sequence of a polymer including different electrodes, and a method of efficiently determining a monomer molecule sequence of a polymer. | 12-19-2013 |
20140008225 | METHOD OF DETERMINING OR ESTIMATING NUCLEOTIDE SEQUENCE OF NUCLEIC ACID - A method of determining or estimating a nucleotide sequence of a nucleic acid by using a device with a nanopore. | 01-09-2014 |
20140021047 | METHOD FOR ANALYZING BIOMOLECULES USING ASYMMETRIC ELECTROLYTE CONCENTRATION - A method and system for analyzing biomolecules using a high concentration electrolytic solution and a low concentration electrolytic solution. | 01-23-2014 |
20140045270 | DEVICE HAVING NANOPORE WITH THIOL-CONTAINING MATERIAL ATTACHED TO GOLD LAYER AND METHOD OF ANALYZING NUCLEIC ACID USING THE DEVICE - Provided is a device with a nanopore that has a thiol-containing material bound to a gold layer, methods of producing the devices, and methods of analyzing nucleic acid using the devices. | 02-13-2014 |
20140062454 | NANOSENSORS INCLUDING GRAPHENE AND METHODS OF MANUFACTURING THE SAME - Nanosensors including graphene and methods of manufacturing the same. A nanosensor includes a first insulating layer in which a first nanopore is formed; a graphene layer that is disposed on the first insulating layer and having a second nanopore or a nanogap formed therein adjacent to the first nanopore; and a marker element that is disposed adjacent to the graphene layer and identifies a position of the graphene layer. | 03-06-2014 |
20140125310 | NANOGAP DEVICE AND METHOD OF PROCESSING SIGNAL FROM THE NANOGAP DEVICE - A nanogap device includes a first insulation layer having a nanopore formed therein, a first nanogap electrode which may be formed on the first insulation layer and may be divided into two parts with a nanogap interposed between the two parts, the nanogap facing the nanopore, a second insulation layer formed on the first nanogap electrode, a first graphene layer formed on the second insulation layer, a first semiconductor layer formed on the first graphene layer, a first drain electrode formed on the first semiconductor layer, and a first source electrode formed on the first graphene layer such as to be apart from the first semiconductor layer. | 05-08-2014 |
20140125322 | NANOGAP DEVICE AND METHOD OF PROCESSING SIGNAL FROM THE NANOGAP DEVICE - A nanogap device which may include a first insulation layer having a nanopore formed therein, a first channel layer which may be on the first insulation layer, a first source electrode and a first drain electrode which may be respectively in contact with both ends of the first channel layer, a second insulation layer which may cover the first channel layer, the first source electrode, and the first drain electrode, and a first nanogap electrode which may be on the second insulation layer and may be divided into two parts with a nanogap, which faces the nanopore, interposed between the two parts. | 05-08-2014 |
20140202866 | NANOSENSOR AND METHOD OF MANUFACTURING SAME - A nanosensor may include a substrate that has a hole formed therein, a first insulating layer that is disposed on the substrate and has a nanopore formed therein, first and second electrodes that are disposed on the first insulating layer and are spaced apart from each other, first and second electrode pads that are disposed on the first and second electrodes, respectively, and a protective layer disposed on the first and second electrode pads. A method of manufacturing a nanosensor may include forming a first insulating layer, graphene, and a metal layer on a substrate, patterning the metal layer and the graphene, forming a protective layer on a portion of the graphene and the metal layer, exposing a portion of the graphene by removing a portion of the protective layer, forming a hole in the substrate, and forming a nanopore in the first insulating layer and the graphene to be connected to the hole. | 07-24-2014 |
20140302439 | METHOD OF MANUFACTURING GRAPHENE, CARBON NANOTUBES, FULLERENE, GRAPHITE OR A COMBINATION THEREOF HAVING A POSITION SPECIFICALLY REGULATED RESISTANCE - Provided are a method of manufacturing graphene, carbon nanotubes, fullerene, graphite, or a combination thereof having a regulated resistance, and a material manufactured using the method. | 10-09-2014 |
20150069329 | NANOPORE DEVICE INCLUDING GRAPHENE NANOPORE AND METHOD OF MANUFACTURING THE SAME - Provided are a nanopore device with resolution improved by graphene nanopores, and a method of manufacturing the same. The nanopore device includes: a first insulating layer; a graphene layer disposed on the first insulating layer and having a nanopore formed at a center portion of the graphene layer; and first and second electrode layers disposed respectively at both sides of the nanopore on a top surface of the graphene layer, wherein a center region of the first insulating layer is removed such that the center portion of the graphene layer is exposed to the outside. | 03-12-2015 |